Relationship:9
<html> <style> .ui-autocomplete {
max-height: 100px; overflow-y: auto; overflow-x: hidden; padding-right: 20px;
}
- html .ui-autocomplete {
height: 100px;
}
.ui-menu .ui-menu-item a
{ display: block; padding: 1px 1px 1px 1px; text-decoration: none; cursor: pointer; font-size: 13px; }
</style>
<link type='text/css' rel='stylesheet' href='/aopwiki/extensions/jquery-ui-1.9.2/themes/base/jquery-ui.css'> <script type="text/javascript" src="/aopwiki/extensions/jquery-ui-1.9.2/ui/jquery-ui.js"></script> <script type="text/javascript" src="/aopwiki/extensions/EPA/Common_Functions.js"></script> <script type="text/javascript" src="/aopwiki/extensions/EPA/MOA_Species.js"></script> <script type="text/javascript" src="/aopwiki/extensions/EPA/MOA_Chemicals.js"></script> <script type="text/javascript" src="/aopwiki/extensions/EPA/MOA_Key_Event.js"></script> </html>
Contents
Key Event Relationship Overview
Description of Relationship
Upstream Event | Downstream Event/Outcome |
---|---|
3-hydroxyacyl-CoA dehydrogenase type-2 activity, Decreased | Mitochondrial fatty acid beta-oxidation, Decreased |
AOPs Referencing Relationship
AOP Name | Type of Relationship | Weight of Evidence | Quantitative Understanding |
---|---|---|---|
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis | Directly Leads to | Strong |
Taxonomic Applicability
<html> <button id="SpeciesList">Add Species from list</button> </html>
Common Name | Scientific Name | Evidence | Links |
---|
How Does This Key Event Relationship Work
Biological Plausibility
Empirical Support for Linkage
- People with the G1528C mutation in HSD17B10 gene exhibit hepatomegaly and steatosis [1].
- Post mortem analyses of livers from children who died prior to 1 year of age demonstrated a link between steatosis \and 3-hydroxyacyl-CoA dehydrogenase activity [2].
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?
Uncertainties or Inconsistencies
Evidence Supporting Taxonomic Applicability
References
- ↑ Tyni T1, Rapola J, Paetau A, Palotie A, Pihko H. 1997. Pathology of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation. Pediatr Pathol Lab Med 17(3):427-47.
- ↑ Boles RG1, Buck EA, Blitzer MG, Platt MS, Cowan TM, Martin SK, Yoon H, Madsen JA, Reyes-Mugica M, Rinaldo P. 1998. Retrospective biochemical screening of fatty acid oxidation disorders in postmortem livers of 418 cases of sudden death in the first year of life. J Pediatr 132(6):924-33.