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Revision as of 17:30, 20 April 2016
Contents
Key Event Relationship Overview
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Description of Relationship
Upstream Event | Downstream Event/Outcome |
---|---|
Oxidative Stress, Increase | Glutathione, Oxidation |
AOPs Referencing Relationship
AOP Name | Type of Relationship | Weight of Evidence | Quantitative Understanding |
---|---|---|---|
Oxidative Stress Leading to Arterial Stiffness | Directly Leads to | Strong | Moderate |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
---|---|---|---|
Homo sapiens | Homo sapiens | Strong | NCBI |
Bos taurus | Bos taurus | NCBI | |
Rattus norvegicus | Rattus norvegicus | NCBI |
How Does This Key Event Relationship Work
Under physiological conditions, glutathione (GSH) functions as an anti-oxidant by defending the cell from products of oxidative stress (Kalinina et al., 2014). It is predominantly found in the cell as the reduced form while the oxidized form glutathione disulfide (GSSG) generally does not exceed 1% of its total cellular context. When exposed to oxidants like peroxides, oxidation of GSH results in the formation of GSSG, thus altering the redox state of the cell (Pullar et al., 2001). This imbalance in GSH/GSSG ratio is a marker of oxidative stress and contributes to endothelial dysfunction.
Weight of Evidence
Biological Plausibility
Empirical Support for Linkage
Include consideration of temporal concordance here
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?