Developers' Handbooks

Ver. Release Date View Download Release Notes Forum Links
2.5 July 15, 2022 Digital Copy, v2.5 Download
  • Added section to define the AOP development strategy
  • Stressors replace with Prototypical Stressors
  • Guidance for Evidence Collection Strategy for Key Event Relationships
  • Guidance for describing modulating factors for Key Event Relationships and AOPs
  • Introduced tabular format for summarizing evidence supporting essentiality of Key Events
  • Guidance for discussing potential applications of AOPs
Pdf iconAOP_Developers_Handbook_2.5_release_notes.pdf
2.0 February 14, 2018 Pdf iconAOP_Handbook_release_2018.pdf Download

OECD (2018), "Users' Handbook supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways", OECD Series on Adverse Outcome Pathways, No. 1, OECD Publishing, Paris,

1.0 September 25, 2014 Pdf iconAOP_Handbook_September_25_2014_release.pdf Download

This document is a supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways (AOPs) [ENV/JM/MONO(2013)6] (AOP guidance hereafter). The AOP Guidance, published in 2013, only one year after the OECD programme on the development of AOPs was initiated, was considered a first version which would be revised as expert groups and member countries gained experience in developing and assessing AOPs. This handbook contains an updated template for AOP development and provides focused and practical instructions for both AOP developers and reviewers and is intended to assist in identifying, organising and evaluating critical information on key events (KE) as well as linkages between KEs within the AOP (i.e., AOP development). It also provides more evolved and explicit guidance on how to assess the weight of evidence (WOE) (degree of confidence) supporting the overall AOP and its relevance for life stage, sex and taxonomy (i.e., AOP evaluation). The handbook is intended to be used as a supplement to the AOP guidance and a replacement for the AOP Template (Part II of the guidance) and evaluation for which improvement was needed.