2157 |
Abnormal Cardiac Structure and Function |
Organ |
Jul 31, 2023 |
Jul 31, 2023 |
|
2264 |
Lysolecithin cell membrane integration, increased |
Cellular |
Oct 1, 2024 |
Oct 1, 2024 |
- Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration
|
2263 |
Lysolecithin, increased |
Cellular |
Oct 1, 2024 |
Oct 1, 2024 |
- Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration
- Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
|
1253 |
MLL chromosomal translocation |
Cellular |
Dec 16, 2016 |
Aug 1, 2022 |
- Inhibitor binding to topoisomerase II leading to infant leukaemia
|
2262 |
Neuropathy target esterase, inhibited |
Molecular |
Oct 1, 2024 |
Oct 1, 2024 |
- Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration
- Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
|
2265 |
Oligodendrocyte death, increased |
Cellular |
Oct 1, 2024 |
Oct 1, 2024 |
- Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration
- Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
|
281 |
Thyroxine (T4) in serum, Decreased |
Tissue |
Nov 29, 2016 |
Oct 10, 2022 |
- Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
- Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
- Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Thyroperoxidase inhibition leading to altered amphibian metamorphosis
- Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
- Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
- Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
- Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
- Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
- Thyroperoxidase inhibition leading to altered visual function via decreased eye size
- Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
- Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
- Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
- Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
- Kidney dysfunction by decreased thyroid hormone
- Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
- Pendrin inhibition leading to altered amphibian metamorphosis
- Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
- Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
- AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
|
1094 |
, hyperuricemia |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1027 |
, Learning and memory, impairment |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1796 |
11β-hydroxylase inhibition |
Molecular |
Jul 13, 2020 |
Jul 13, 2020 |
- Inhibition of 11β-hydroxylase leading to decresed population trajectory
|
2250 |
17β-Hydroxysteroid dehydrogenase 2, inhibition |
Molecular |
Aug 9, 2024 |
Aug 12, 2024 |
|
1387 |
7α-hydroxypregnenolone synthesis in the brain, decreased |
Cellular |
May 2, 2017 |
May 17, 2017 |
- Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
- Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
|
382 |
Aberrant, Dendritic morphology |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
|
2208 |
Aberrant, synaptic formation and plasticity |
Organ |
Jan 25, 2024 |
Jan 25, 2024 |
- Estrogen antagonism leading to increased risk of autism-like behavior
- Binding and activation of GPER leading to learning and memory impairments
|
2166 |
Abnormal expression of NO |
Cellular |
Aug 20, 2023 |
Aug 20, 2023 |
- Demethylation of PPAR promotor leading to vascular disrupting effects
|
1995 |
Abnormal lipid metabolism |
Cellular |
Apr 7, 2022 |
Apr 7, 2022 |
- G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
|
560 |
Abnormal, Foraging activity and behavior |
Individual |
Nov 29, 2016 |
Jun 7, 2018 |
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
- Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
- Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
- Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
- Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure
- Weather event contributes abnormal foraging leading to colony loss/failure
- Nosema infection increases energetic demands leading to colony loss/failure
|
1952 |
Abnormal, Glucose homeostasis |
Organ |
Nov 18, 2021 |
Nov 18, 2021 |
- Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
|
183 |
Abnormal, Morphogenesis |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
2094 |
Abnormal, neuroblast migration |
Cellular |
Jan 19, 2023 |
Jan 19, 2023 |
- Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
|
1891 |
abnormal, placental labyrinth vasculature morphology |
Tissue |
May 31, 2021 |
May 31, 2021 |
- AhR activation leading to preeclampsia
|
1108 |
Abnormal, Role change within caste |
Population |
Nov 29, 2016 |
Jun 7, 2018 |
- Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
- Nosema infection causes abnormal role change that leads to colony loss/failure
|
564 |
Abnormal, Roll change within caste |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
- Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure
- Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
|
535 |
Abnormal, Sperm penetration (polyspermy) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
- Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
|
1684 |
Abnormalities, Cardiac outflow tract formation |
Organ |
Aug 13, 2019 |
Aug 13, 2019 |
- TBX1 inhibition leading to congenital cardiac conotruncal anomalies
|
2242 |
Abnormality, dendritic spine morphology |
Cellular |
Jul 14, 2024 |
Jul 14, 2024 |
- Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
|
1591 |
Absorption of photon energy |
Molecular |
Feb 3, 2019 |
Feb 5, 2019 |
|
571 |
Accelerated, Aging |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
|
1605 |
Accumulation of misfolded proteins |
Cellular |
Mar 6, 2019 |
Mar 6, 2019 |
- Inhibition of N-linked glycosylation leads to liver injury
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
|
46 |
Accumulation, Biological membranes |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Narcosis leading to respiratory failure
|
68 |
Accumulation, Collagen |
Tissue |
Nov 29, 2016 |
May 17, 2023 |
- Protein Alkylation leading to Liver Fibrosis
- Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
- Endocytic lysosomal uptake leading to liver fibrosis
- Binding to ACE2 leading to lung fibrosis
- Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis
- Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
|
1942 |
Accumulation, Cytosolic toxic Tau oligomers |
Cellular |
Oct 26, 2021 |
Oct 26, 2021 |
- A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
|
570 |
Accumulation, Damaged mitochondrial DNA |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
|
327 |
Accumulation, Fatty acid |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
- AhR activation leading to hepatic steatosis
- NR1I3 (CAR) suppression leading to hepatic steatosis
- NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
- Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
|
846 |
Accumulation, Highly carboxylated porphyrins |
Organ |
Nov 29, 2016 |
May 7, 2018 |
- Aryl hydrocarbon receptor activation leading to uroporphyria
|
291 |
Accumulation, Triglyceride |
Cellular |
Nov 29, 2016 |
Mar 26, 2024 |
- LXR activation leading to hepatic steatosis
- AhR activation leading to hepatic steatosis
- Glucocorticoid Receptor activation leading to hepatic steatosis
- Pregnane X Receptor (PXR) activation leads to liver steatosis
- Liver X Receptor (LXR) activation leads to liver steatosis
- Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
|
1938 |
ACE2 increased shedding |
Molecular |
Oct 17, 2021 |
Oct 17, 2021 |
- ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
|
1876 |
ACE2 shedding effects on viral entry |
Cellular |
Apr 28, 2021 |
Apr 28, 2021 |
|
10 |
Acetylcholine accumulation in synapses |
Cellular |
Nov 29, 2016 |
Jun 26, 2020 |
- Acetylcholinesterase inhibition leading to acute mortality
- Acetylcholinesterase Inhibition Leading to Neurodegeneration
- Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
- Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
- Various neuronal effects induced by elavl3, sox10, and mbp
|
12 |
Acetylcholinesterase (AchE) Inhibition |
Cellular |
Nov 29, 2016 |
Apr 29, 2020 |
- Acetylcholinesterase inhibition leading to acute mortality
- Acetylcholinesterase Inhibition Leading to Neurodegeneration
- Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
- Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
- Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1724 |
Acinar cell proliferation |
Cellular |
Jan 8, 2020 |
Jan 8, 2020 |
- Trypsin inhibition leading to pancreatic acinar cell tumors
|
1340 |
Activate, calmodulin |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
1359 |
Activate, GABA-A receptor |
Molecular |
Apr 14, 2017 |
Apr 14, 2017 |
- Molecular events lead to epilepsy
|
1379 |
Activate, leukocyte |
Cellular |
Apr 17, 2017 |
Apr 17, 2017 |
|
1380 |
Activate, mucosal defense |
Tissue |
Apr 17, 2017 |
Apr 17, 2017 |
|
1383 |
Activate, phospholipase |
Molecular |
Apr 17, 2017 |
Apr 17, 2017 |
- Gastric ulcer formation
- Helicobacter pylori to gastric ulcer
|
1337 |
Activate, PLC (Phospholipase C) |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
1360 |
Activate, presynaptic neuron 2 |
Molecular |
Apr 14, 2017 |
Apr 14, 2017 |
- Molecular events lead to epilepsy
|
2173 |
Activated AKT/ERK/PI3K pathway |
Cellular |
Aug 21, 2023 |
Aug 21, 2023 |
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
|
2170 |
Activated ANG/Tie2 pathway |
Molecular |
Aug 21, 2023 |
Aug 21, 2023 |
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
|
2171 |
Activated BMP/TGF-beta pathway |
Cellular |
Aug 21, 2023 |
Aug 21, 2023 |
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
|
2172 |
Activated Wnt/Frizzled pathway |
Cellular |
Aug 21, 2023 |
Aug 21, 2023 |
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
|
1385 |
Activated, gastric ulcer formation |
Organ |
Apr 17, 2017 |
Jun 2, 2017 |
- Gastric ulcer formation
- NSAID induced PTGS1 inactivation to gastric ulcer
- NSAID induced PTGS2 inactivation to gastric ulcer
- Helicobacter pylori to gastric ulcer
|
1421 |
Activated, LXR |
Molecular |
Jun 2, 2017 |
Jun 2, 2017 |
- NFE2/Nrf2 repression to steatosis
|
1355 |
Activated, membrane depolarization |
Cellular |
Apr 14, 2017 |
Jun 2, 2017 |
- Molecular events lead to epilepsy
- presynaptic neuron 1 activation to epilepsy
- presynaptic neuron 2 repression to epilepsy
|
1351 |
Activated, NMDA receptor |
Molecular |
Apr 14, 2017 |
Jun 2, 2017 |
- Molecular events lead to epilepsy
- presynaptic neuron 1 activation to epilepsy
|
1349 |
Activated, presynaptic neuron 1 |
Molecular |
Apr 14, 2017 |
Jun 2, 2017 |
- Molecular events lead to epilepsy
- presynaptic neuron 1 activation to epilepsy
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1352 |
Activated, voltage-gated sodium channel |
Molecular |
Apr 14, 2017 |
Jun 2, 2017 |
- Molecular events lead to epilepsy
- presynaptic neuron 1 activation to epilepsy
|
2169 |
Activation of Angiogenic cytokines |
Cellular |
Aug 20, 2023 |
Aug 20, 2023 |
- Demethylation of PPAR promotor leading to vascular disrupting effects
|
2168 |
Activation of angiopoietin like protein 4 |
Cellular |
Aug 20, 2023 |
Aug 20, 2023 |
- Demethylation of PPAR promotor leading to vascular disrupting effects
|
2038 |
Activation of calpain signalling |
Cellular |
Jul 25, 2022 |
Jul 25, 2022 |
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
|
1448 |
activation of CCAAT/enhancer-binding protein alpha |
Molecular |
Jul 24, 2017 |
Jul 24, 2017 |
- Epigenetic modification of PPARG leading to adipogenesis
|
1391 |
Activation of Cyp2E1 |
Molecular |
May 30, 2017 |
Jun 19, 2021 |
- Cyp2E1 Activation Leading to Liver Cancer
- Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
|
1815 |
Activation of ER stress |
Cellular |
Nov 2, 2020 |
Nov 2, 2020 |
- Immune mediated hepatitis
- Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
|
1606 |
Activation of hepatic stellate cells |
Cellular |
Mar 6, 2019 |
Mar 6, 2019 |
- Inhibition of N-linked glycosylation leads to liver injury
|
2009 |
Activation of inflammation pathway |
Cellular |
May 31, 2022 |
May 31, 2022 |
- Adverse outcome pathway of PM-induced respiratory toxicity
- Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
|
2036 |
Activation of metabotropic glutamate receptor |
Molecular |
Jul 25, 2022 |
Jul 25, 2022 |
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
|
2146 |
Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 |
Molecular |
May 25, 2023 |
Jul 28, 2023 |
- Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release
- Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
|
2167 |
Activation of MMP-2 MMP-9 |
Cellular |
Aug 20, 2023 |
Aug 20, 2023 |
- Demethylation of PPAR promotor leading to vascular disrupting effects
|
1238 |
Activation of oxidative stress pathway |
Molecular |
Nov 29, 2016 |
Jun 19, 2017 |
|
2165 |
Activation of PPAR |
Cellular |
Aug 20, 2023 |
Aug 20, 2023 |
- Demethylation of PPAR promotor leading to vascular disrupting effects
|
1507 |
Activation of PPARγ |
Molecular |
Mar 18, 2018 |
Mar 18, 2018 |
|
2249 |
Activation of sensory receptors |
Molecular |
Jul 29, 2024 |
Jul 29, 2024 |
|
1028 |
Activation of specific nuclear receptors, PPAR-gamma activation |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARgamma activation leading to sarcomas in rats, mice, and hamsters
- Epigenetic modification of PPARG leading to adipogenesis
|
288 |
Activation of specific nuclear receptors, Transcriptional change |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
|
1271 |
Activation of TGF-β signaling |
Cellular |
Feb 15, 2017 |
Feb 15, 2017 |
- Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
|
1974 |
Activation of Tumor Protein 53 |
Cellular |
Mar 9, 2022 |
Mar 17, 2022 |
- Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
|
2163 |
Activation Sema6A |
Cellular |
Aug 20, 2023 |
Aug 20, 2023 |
- Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
|
1288 |
Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
|
1336 |
Activation, 5-HT2A (Serotonin 2A) |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
9 |
Activation, 5HT2c |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Kidney toxicity induced by activation of 5HT2C
|
18 |
Activation, AhR |
Molecular |
Nov 29, 2016 |
Feb 28, 2024 |
- Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
- AhR activation leading to hepatic steatosis
- Aryl hydrocarbon receptor activation leading to uroporphyria
- Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
- Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
- AhR activation leading to preeclampsia
- Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway
- Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway
- Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
- Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway
- Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway
- Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway
- Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway
- Activation of the AhR leading to metastatic breast cancer
- Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
- Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
- AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- AhR activation leading to liver fibrosis
- AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
|
1299 |
Activation, AKT |
Molecular |
Apr 12, 2017 |
Apr 12, 2017 |
- G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
|
484 |
Activation, AKT2 |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- AKT2 activation leading to hepatic steatosis
|
785 |
Activation, Androgen receptor |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
- Androgen receptor activation leading to prostate cancer
|
1309 |
Activation, aPKC |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
|
1038 |
Activation, beta-2 adrenergic receptor |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
|
1575 |
Activation, Caspase 8 pathway |
Molecular |
Jan 7, 2019 |
Mar 7, 2019 |
- IKK complex inhibition leading to liver injury
|
2188 |
Activation, caspases |
Cellular |
Sep 14, 2023 |
Sep 14, 2023 |
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
|
66 |
Activation, ChREBP |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- LXR activation leading to hepatic steatosis
- NR1I3 (CAR) suppression leading to hepatic steatosis
|
715 |
Activation, Constitutive androstane receptor |
Molecular |
Nov 29, 2016 |
Jun 28, 2018 |
- Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
|
398 |
Activation, Dendritic Cells |
Cellular |
Nov 29, 2016 |
Dec 3, 2020 |
- Covalent Protein binding leading to Skin Sensitisation
- Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
|
2164 |
Activation, Dll4-Notch pathway |
Cellular |
Aug 20, 2023 |
Aug 20, 2023 |
- Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
|
941 |
Activation, EGFR |
Molecular |
Nov 29, 2016 |
Mar 8, 2023 |
- EGFR Activation Leading to Decreased Lung Function
|
913 |
Activation, Epidermal Growth Factor Receptor |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1181 |
Activation, Estrogen receptor |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Estrogen receptor activation leading to breast cancer
|
1065 |
Activation, estrogen receptor alpha |
Molecular |
Nov 29, 2016 |
Aug 14, 2024 |
- Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
- Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
- Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
|
116 |
Activation, FAS |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- LXR activation leading to hepatic steatosis
|
1197 |
Activation, Fibroblasts |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Estrogen receptor activation leading to breast cancer
- AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
|
1293 |
Activation, FOXO |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
|
1304 |
Activation, FXR |
Molecular |
Apr 12, 2017 |
Apr 12, 2017 |
|
122 |
Activation, Glucocorticoid Receptor |
Molecular |
Nov 29, 2016 |
Jul 7, 2020 |
- Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Glucocorticoid Receptor activation leading to hepatic steatosis
- Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
|
760 |
Activation, Glutamate-gated chloride channel |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Glutamate-gated chloride channel activation leading to acute mortality
|
1018 |
Activation, Glutamate-gated chloride channels |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1157 |
Activation, Hepatic nuclear receptor(s) |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
|
1280 |
Activation, HIF-1 |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
|
2162 |
Activation, HIF1α |
Cellular |
Aug 20, 2023 |
Aug 20, 2023 |
- Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
|
1303 |
Activation, HSD17B4 |
Molecular |
Apr 12, 2017 |
Apr 12, 2017 |
|
151 |
Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways |
Molecular |
Nov 29, 2016 |
Nov 5, 2020 |
|
1297 |
Activation, insulin receptor |
Molecular |
Apr 12, 2017 |
Apr 12, 2017 |
|
762 |
Activation, ionotropic GABA Receptor chloride channel |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
|
1282 |
Activation, JAK/STAT pathway |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
|
1292 |
Activation, JNK |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
- Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
|
1205 |
Activation, Juvenile hormone receptor |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Juvenile hormone receptor agonism leading to male offspring induction associated population decline
|
826 |
Activation, Keratinocytes |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Covalent Protein binding leading to Skin Sensitisation
|
1302 |
Activation, L-FABP |
Molecular |
Apr 12, 2017 |
Apr 13, 2017 |
|
1468 |
Activation, Latent Transforming Growth Factor Beta 1 |
Molecular |
Aug 16, 2017 |
Aug 16, 2017 |
- Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
|
165 |
Activation, Long term AHR receptor driven direct and indirect gene expression changes |
Cellular |
Nov 29, 2016 |
Dec 2, 2016 |
- Sustained AhR Activation leading to Rodent Liver Tumours
|
1314 |
Activation, LRH-1 |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
|
167 |
Activation, LXR |
Molecular |
Nov 29, 2016 |
May 21, 2024 |
- LXR activation leading to hepatic steatosis
- NR1I3 (CAR) suppression leading to hepatic steatosis
- Liver X Receptor (LXR) activation leads to liver steatosis
|
483 |
Activation, LXR alpha |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NFE2L2/FXR activation leading to hepatic steatosis
|
1198 |
Activation, Macrophages |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Estrogen receptor activation leading to breast cancer
- AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
- Activation of reactive oxygen species leading the atherosclerosis
|
1998 |
Activation, Microglia |
Cellular |
Apr 7, 2022 |
Apr 7, 2022 |
- Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
|
1300 |
Activation, mTORC1 |
Molecular |
Apr 12, 2017 |
Apr 12, 2017 |
- G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
|
1298 |
Activation, mTORC2 |
Molecular |
Apr 12, 2017 |
Apr 12, 2017 |
|
879 |
Activation, MTTP |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- NFE2L2/FXR activation leading to hepatic steatosis
|
1602 |
Activation, Muscarinic Acetylcholine Receptors |
Molecular |
Feb 6, 2019 |
Apr 17, 2020 |
- Acetylcholinesterase Inhibition Leading to Neurodegeneration
|
1174 |
Activation, NADPH Oxidase |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
|
559 |
Activation, Nicotinic acetylcholine receptor |
Molecular |
Nov 29, 2016 |
Jun 7, 2018 |
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
- Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
- Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
- Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
- Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
|
479 |
Activation, NR1H4 |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NFE2L2/FXR activation leading to hepatic steatosis
|
478 |
Activation, NRF2 |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NFE2L2/FXR activation leading to hepatic steatosis
|
2030 |
Activation, PARP1 |
Molecular |
Jul 18, 2022 |
Jul 18, 2022 |
- Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway
|
1310 |
Activation, PI3K |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
- G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
|
227 |
Activation, PPARα |
Molecular |
Nov 29, 2016 |
Dec 28, 2020 |
- PPARα activation in utero leading to impaired fertility in males
- PPARα activation leading to impaired fertility in adult male rodents
- NFE2L2/FXR activation leading to hepatic steatosis
- PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
- PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
- G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
|
234 |
Activation, PPARα & PPARγ |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
|
380 |
Activation, Pre-MIE: Metabolism of AFB1 |
Molecular |
Nov 29, 2016 |
Nov 29, 2016 |
|
239 |
Activation, Pregnane-X receptor, NR1l2 |
Molecular |
Nov 29, 2016 |
Oct 31, 2024 |
- Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Pregnane X Receptor (PXR) activation leads to liver steatosis
- Activation, Pregnane-X receptor, NR1l2 leads to Increased, plasma low-density lipoprotein (LDL) cholesterol
|
1369 |
Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) |
Molecular |
Apr 17, 2017 |
Apr 17, 2017 |
|
1370 |
Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2) |
Molecular |
Apr 17, 2017 |
Apr 17, 2017 |
|
245 |
Activation, PXR/SXR |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol
- NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
|
258 |
Activation, SCD-1 |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- LXR activation leading to hepatic steatosis
|
480 |
Activation, SHP |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NFE2L2/FXR activation leading to hepatic steatosis
|
924 |
Activation, Sp1 |
Molecular |
Nov 29, 2016 |
Aug 20, 2021 |
|
457 |
Activation, SREBF1 |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NR1I3 (CAR) suppression leading to hepatic steatosis
- AKT2 activation leading to hepatic steatosis
|
1301 |
Activation, SREBP-1 |
Molecular |
Apr 12, 2017 |
Apr 12, 2017 |
|
264 |
Activation, SREBP-1c |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- LXR activation leading to hepatic steatosis
|
265 |
Activation, Stellate cells |
Cellular |
Nov 29, 2016 |
Nov 10, 2019 |
- Protein Alkylation leading to Liver Fibrosis
- Endocytic lysosomal uptake leading to liver fibrosis
- AhR activation leading to liver fibrosis
|
978 |
Activation, Suppression of NFAT activation and hindrance of nuclear localization |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
|
1283 |
Activation, TGF-beta pathway |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
- Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
|
1576 |
Activation, Tissue resident cells (Kuppfer cells) |
Cellular |
Jan 7, 2019 |
Jan 7, 2019 |
- IKK complex inhibition leading to liver injury
|
1469 |
Activation, Transforming Growth Factor beta pathway |
Molecular |
Aug 16, 2017 |
Aug 16, 2017 |
- Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
|
272 |
Activation/Proliferation, T-cells |
Organ |
Nov 29, 2016 |
Nov 5, 2020 |
- Covalent Protein binding leading to Skin Sensitisation
- Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
|
1793 |
Activator protein 1 activation |
Cellular |
Jul 9, 2020 |
Jul 9, 2020 |
- Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
|
1679 |
Acute inhalation toxicity |
Individual |
Jul 3, 2019 |
Jul 3, 2019 |
|
1955 |
Acute Myeloid Leukemia |
Individual |
Dec 3, 2021 |
Dec 3, 2021 |
- Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
|
1937 |
ADAM17 expression induction |
Cellular |
Oct 17, 2021 |
Oct 17, 2021 |
- ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
|
2177 |
Adhesion disfunction |
Cellular |
Aug 21, 2023 |
Aug 21, 2023 |
|
2025 |
Affected folate transporter |
Cellular |
Jul 14, 2022 |
Jul 14, 2022 |
- Ceramide synthase inhibition leading to neural tube defects
|
25 |
Agonism, Androgen receptor |
Molecular |
Nov 29, 2016 |
Mar 20, 2017 |
- Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
- Androgen receptor agonism leading to male-biased sex ratio
- Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
- Androgen receptor agonism leading to long anogenital distance in female offspring
|
111 |
Agonism, Estrogen receptor |
Molecular |
Nov 29, 2016 |
Jun 24, 2024 |
- Estrogen receptor agonism leading to reproductive dysfunction
- ER agonism leading to skewed sex ratios due to altered sexual differentiation in males
- ER agonism leading to reduced survival due to renal failure
- Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
- Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
|
1984 |
Agonism, Estrogen Receptor alpha |
Molecular |
Apr 5, 2022 |
Apr 5, 2022 |
|
2201 |
Agonism, Retinoic acid receptor |
Molecular |
Jan 14, 2024 |
Jan 24, 2024 |
- Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory
- Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
- Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function
|
1586 |
Airway epithelial injury |
Cellular |
Jan 30, 2019 |
Jan 30, 2019 |
- α-diketone-induced bronchiolitis obliterans
- AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
|
2086 |
Airway inflammation |
Organ |
Jan 9, 2023 |
Jan 17, 2023 |
- AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
|
2013 |
Airway remodeling |
Organ |
May 31, 2022 |
May 31, 2022 |
- Adverse outcome pathway of PM-induced respiratory toxicity
|
1907 |
Airway Surface Liquid Height, Decreased |
Tissue |
Jul 19, 2021 |
Sep 9, 2021 |
- Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
|
97 |
Alkylation, DNA |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
- Alkylation of DNA leading to cancer 1
- Alkylation of DNA leading to cancer 2
- Alkylation of DNA leading to reduced sperm count
|
244 |
Alkylation, Protein |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Protein Alkylation leading to Liver Fibrosis
- Renal protein alkylation leading to kidney toxicity
|
1210 |
Alteration, Food-web structures |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Juvenile hormone receptor agonism leading to male offspring induction associated population decline
|
1060 |
Alteration, lipid metabolism |
Cellular |
Nov 29, 2016 |
Oct 30, 2023 |
- PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
- Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
|
310 |
Alteration, Wnt pathway |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
|
854 |
Alterations, Cellular proliferation / hyperplasia |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Sustained AhR Activation leading to Rodent Liver Tumours
- Androgen receptor activation leading to prostate cancer
|
2089 |
Altered Bone Cell Homeostasis |
Cellular |
Jan 11, 2023 |
Aug 23, 2024 |
- Deposition of energy leading to occurrence of bone loss
|
2204 |
Altered brain morphology |
Organ |
Jan 14, 2024 |
Jan 14, 2024 |
- Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory
|
2245 |
Altered Cell Differentiation Signaling |
Molecular |
Jul 24, 2024 |
Aug 23, 2024 |
- Deposition of energy leading to occurrence of bone loss
|
1560 |
Altered differentiation |
Cellular |
Dec 20, 2018 |
Mar 17, 2022 |
- Histone deacetylase inhibition leads to neural tube defects
|
2202 |
Altered expression of cell cycle genes |
Molecular |
Jan 14, 2024 |
Mar 7, 2024 |
- Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory
- Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
|
2022 |
Altered function of the brain |
Organ |
Jul 6, 2022 |
Jul 6, 2022 |
|
1214 |
Altered gene expression specific to CAR activation, Hepatocytes |
Cellular |
Nov 29, 2016 |
Dec 19, 2018 |
- Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
|
17 |
Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway |
Molecular |
Nov 29, 2016 |
Aug 19, 2021 |
- Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway
- Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway
|
1921 |
Altered gene expression, NF-kB dependent Interleukin-6 pathway |
Molecular |
Aug 19, 2021 |
Aug 19, 2021 |
- Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway
- Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
|
1917 |
Altered gene expression, NRF2 dependent antioxidant pathway |
Molecular |
Aug 17, 2021 |
Aug 19, 2021 |
- PPARG activation leading to intrahepatic cholestasis
- Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway
- Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
|
1923 |
Altered gene expression, P53 dependent apoptosis pathway |
Molecular |
Aug 19, 2021 |
Aug 19, 2021 |
- Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway
|
1920 |
Altered gene expression, TGF-β dependent fibrosis pathway |
Molecular |
Aug 19, 2021 |
Aug 19, 2021 |
- Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway
|
2221 |
Altered Liver X receptor activity |
Molecular |
Apr 12, 2024 |
Apr 12, 2024 |
- Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|
2005 |
Altered neurotransmission in development |
Cellular |
May 16, 2022 |
Jul 24, 2024 |
- Binding to voltage gate sodium channels during development leads to cognitive impairment
|
2222 |
Altered peroxisome proliferator–activated receptor alpha activity |
Molecular |
Apr 12, 2024 |
Apr 12, 2024 |
- Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|
21 |
Altered regulation, Alpha hemoglobin |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Oxidation of iron in hemoglobin leading to hematotoxicity
|
2066 |
Altered Signaling Pathways |
Molecular |
Sep 28, 2022 |
Feb 13, 2024 |
|
2244 |
Altered Stress Response Signaling |
Molecular |
Jul 24, 2024 |
Aug 26, 2024 |
- Deposition of energy leads to abnormal vascular remodeling
- Deposition of Energy Leading to Learning and Memory Impairment
|
698 |
Altered, Action Potential |
Cellular |
Nov 29, 2016 |
Mar 31, 2022 |
- Altered ion channel activity leading impaired heart function
|
1101 |
Altered, Amphibian metamorphosis |
Organ |
Nov 29, 2016 |
Sep 2, 2020 |
- Thyroperoxidase inhibition leading to altered amphibian metamorphosis
- Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
- Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
- Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
- Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
- Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
- Pendrin inhibition leading to altered amphibian metamorphosis
- Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
- Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
- Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
- Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
|
1243 |
Altered, Ca2+-calmodulin activated signal transduction |
Cellular |
Nov 29, 2016 |
Jun 7, 2018 |
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
- Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
|
317 |
Altered, Cardiovascular development/function |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
- Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
- Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
|
2115 |
Altered, cholesterol metabolism |
Molecular |
Feb 22, 2023 |
Feb 22, 2023 |
- Unknown MIE altering cholesterol metabolism leading to decreased cognition
- Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|
723 |
Altered, Chromosome number |
Cellular |
Nov 29, 2016 |
May 27, 2019 |
- Chemical binding to tubulin in oocytes leading to aneuploid offspring
|
536 |
Altered, Chromosome number (polyploid) zygote |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
- Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
|
1211 |
Altered, food-web structures |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
|
534 |
Altered, Formation of cortical envelope |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
- Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
|
1239 |
Altered, Gene Expression |
Molecular |
Nov 29, 2016 |
Mar 6, 2019 |
- Estrogen receptor activation leading to breast cancer
- Histone deacetylase inhibition leads to neural tube defects
- Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory
|
1930 |
altered, inner ear development |
Organ |
Aug 23, 2021 |
Aug 24, 2021 |
- GSK3beta inactivation leading to increased mortality via defects in developing inner ear
|
339 |
Altered, Larval development |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Estrogen receptor agonism leading to reproductive dysfunction
|
752 |
Altered, Meiotic chromosome dynamics |
Cellular |
Nov 29, 2016 |
May 27, 2019 |
- Chemical binding to tubulin in oocytes leading to aneuploid offspring
- Deposition of ionizing energy leads to population decline via impaired meiosis
- Deposition of ionising energy leads to population decline via pollen abnormal
|
2259 |
Altered, Microbial Bile Acid Metabolism |
Molecular |
Aug 29, 2024 |
Aug 29, 2024 |
|
186 |
Altered, Neuroanatomy |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
|
192 |
Altered, Neurophysiology |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
|
2067 |
Altered, Nitric Oxide Levels |
Cellular |
Sep 28, 2022 |
Apr 13, 2023 |
- Deposition of energy leads to abnormal vascular remodeling
|
1640 |
Altered, Photoreceptor patterning |
Cellular |
May 22, 2019 |
Jun 16, 2021 |
- Inhibition of retinaldehyde dehydrogenase leads to population decline
- Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
|
1240 |
Altered, Protein Production |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Estrogen receptor activation leading to breast cancer
|
363 |
Altered, Reproductive behaviour |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Estrogen receptor agonism leading to reproductive dysfunction
|
1877 |
Altered, retinal layer structure |
Tissue |
May 11, 2021 |
Jul 8, 2022 |
- Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
|
1829 |
Altered, Thyroid hormone-dependent gene expression |
Molecular |
Dec 9, 2020 |
Dec 9, 2020 |
- Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
- Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
- AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation
- Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
|
286 |
Altered, Transcription of genes by the androgen receptor |
Tissue |
Nov 29, 2016 |
Apr 5, 2024 |
- Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
- Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
- Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring
- Androgen receptor (AR) antagonism leading to decreased fertility in females
- 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring
- Androgen receptor activation leading to prostate cancer
- Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring
- Androgen receptor agonism leading to long anogenital distance in female offspring
|
1643 |
Altered, Visual function |
Organ |
May 22, 2019 |
Jul 8, 2022 |
- Inhibition of retinaldehyde dehydrogenase leads to population decline
- Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
- Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
- Thyroperoxidase inhibition leading to altered visual function via decreased eye size
- Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
|
2108 |
Altered, white brain matter |
Tissue |
Feb 21, 2023 |
Feb 21, 2023 |
- Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
- Unknown MIE altering cholesterol metabolism leading to decreased cognition
- Increased reactive oxygen species production leading to decreased cognitive function
- Inhibition of voltage-gated sodium channels leading to decreased cognition
- Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|
1673 |
Alveolar collapse |
Cellular |
Jul 3, 2019 |
Oct 27, 2021 |
- Lung surfactant function inhibition leading to decreased lung function
|
1674 |
Alveolar reopening |
Tissue |
Jul 3, 2019 |
Jul 3, 2019 |
|
1428 |
Analgesia |
Individual |
Jun 8, 2017 |
Jun 8, 2017 |
- Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
- Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
|
2274 |
Androgen receptor activation, increased |
Tissue |
Nov 2, 2024 |
Nov 2, 2024 |
- Androgen receptor agonism leading to long anogenital distance in female offspring
|
1127 |
Anemia, Impaired oxygen and nutrient delivery to tissue, impaired carbon dioxide and waste product removal |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
2160 |
Angiogenesis disfunction |
Organ |
Aug 19, 2023 |
Aug 19, 2023 |
|
2181 |
Angiogenesis dysfunction |
Organ |
Aug 28, 2023 |
Aug 28, 2023 |
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
- Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
- Demethylation of PPAR promotor leading to vascular disrupting effects
- Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway
- Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
|
1935 |
Angiotensin (1-7) levels diminished |
Molecular |
Oct 15, 2021 |
Oct 15, 2021 |
- ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
|
1936 |
Angiotensin II degradation reduced |
Molecular |
Oct 17, 2021 |
Oct 17, 2021 |
- ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
|
1688 |
anogenital distance (AGD), decreased |
Tissue |
Aug 30, 2019 |
Dec 22, 2022 |
- 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring
- Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring
- Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
|
1685 |
Anomalies, Congenital cardiac conotruncal |
Individual |
Aug 13, 2019 |
Aug 13, 2019 |
- TBX1 inhibition leading to congenital cardiac conotruncal anomalies
|
1073 |
anovulation, |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
26 |
Antagonism, Androgen receptor |
Molecular |
Nov 29, 2016 |
Apr 5, 2024 |
- Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring
- Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring
- Androgen receptor (AR) antagonism leading to decreased fertility in females
- Androgen receptor antagonism leading to testicular cancer
- Androgen receptor (AR) antagonism leading to hypospadias in male offspring
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
|
112 |
Antagonism, Estrogen receptor |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Estrogen receptor antagonism leading to reproductive dysfunction
- DNA damage and mutations leading to Metastatic Breast Cancer
- Estrogen antagonism leading to increased risk of autism-like behavior
|
2220 |
Antagonism, Glucocorticoid hormone receptor |
Molecular |
Apr 12, 2024 |
Apr 12, 2024 |
- Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|
638 |
Antagonism, Histamine Receptor (H2) |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Histamine (H2) receptor antagonism leading to reduced survival
|
2232 |
Antagonism, Retinoic acid receptors |
Molecular |
Jun 6, 2024 |
Jun 6, 2024 |
- Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory
|
2027 |
Antagonism, Smoothened receptor |
Molecular |
Jul 15, 2022 |
Jul 28, 2022 |
- Antagonism of Smoothened receptor leading to orofacial clefting
|
1656 |
Antagonism, Thyroid Receptor |
Molecular |
Jun 8, 2019 |
Jan 11, 2021 |
- Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
- Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|
1691 |
Antagonism,LH receptor |
Molecular |
Oct 3, 2019 |
Oct 3, 2019 |
- Luteinizing hormone receptor antagonism leading to reproductive dysfunction
|
1432 |
Anti-depressant Activity |
Individual |
Jun 23, 2017 |
Jun 23, 2017 |
- Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
- Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
|
1169 |
Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
|
1148 |
Anticoagulant rodenticide interferes with gamma-carboxyglutamate formation, Inhibition of protein synthesis in bone |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1262 |
Apoptosis |
Cellular |
Feb 7, 2017 |
Feb 28, 2024 |
- AOP from chemical insult to cell death
- NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
- Histone deacetylase inhibition leading to testicular atrophy
- Inhibition of N-linked glycosylation leads to liver injury
- Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway
- Activation of the AhR leading to metastatic breast cancer
- Adverse outcome pathway of PM-induced respiratory toxicity
- AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
- Antagonism of Smoothened receptor leading to orofacial clefting
- Decrease, GLI1/2 target gene expression leads to orofacial clefting
- Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
- Decrease, cholesterol synthesis leads to orofacial clefting
- Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
- Binding and activation of GPER leading to learning and memory impairments
- Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
|
525 |
Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
|
2184 |
Apoptosis of vascular smooth muscle cells |
Cellular |
Sep 4, 2023 |
Sep 4, 2023 |
|
1817 |
Apoptotic cell death |
Cellular |
Nov 2, 2020 |
Nov 2, 2020 |
- Immune mediated hepatitis
- Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway
|
1443 |
Atherosclerosis |
Individual |
Jun 29, 2017 |
Dec 18, 2023 |
- Substance interaction with lung resident cell membrane components leading to atherosclerosis
|
2209 |
autism-like behavior |
Individual |
Jan 25, 2024 |
Jan 25, 2024 |
- Estrogen antagonism leading to increased risk of autism-like behavior
|
1814 |
benzoquinone imine and acylglucuronide metabolites |
Molecular |
Nov 2, 2020 |
Nov 2, 2020 |
- Immune mediated hepatitis
|
1755 |
beta-catenin activation |
Cellular |
Mar 23, 2020 |
Nov 25, 2022 |
- Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
|
214 |
Bile accumulation, Pathological condition |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
|
857 |
Binding as antagonist, Antagonist binding to PPARalpha ligand binding domain |
Molecular |
Nov 29, 2016 |
Nov 29, 2016 |
|
667 |
Binding at picrotoxin site, iGABAR chloride channel |
Molecular |
Nov 29, 2016 |
Apr 29, 2019 |
- Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
|
2218 |
Binding of (ant)agonist to liver X receptor |
Molecular |
Apr 12, 2024 |
Apr 12, 2024 |
- Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|
2219 |
Binding of (ant)agonist to peroxisome proliferator–activated receptor alpha |
Molecular |
Apr 12, 2024 |
Apr 12, 2024 |
- Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|
1851 |
Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) |
Molecular |
Mar 30, 2021 |
Mar 30, 2021 |
- Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis
- Binding to ACE2 leading to lung fibrosis
|
875 |
Binding of agonist, Ionotropic glutamate receptors |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
- Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
|
387 |
Binding of agonist, NMDARs |
Molecular |
Nov 29, 2016 |
Nov 29, 2016 |
|
2217 |
Binding of antagonist to glucocorticoid hormone receptor |
Molecular |
Apr 12, 2024 |
Apr 12, 2024 |
- Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|
2216 |
Binding of antagonist to thyroid hormone receptor |
Molecular |
Apr 12, 2024 |
Apr 12, 2024 |
- Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|
201 |
Binding of antagonist, NMDA receptors |
Molecular |
Nov 29, 2016 |
Jun 13, 2018 |
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
|
998 |
Binding of antagonist, PPAR alpha |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Antagonist binding to PPARα leading to body-weight loss
|
1199 |
Binding of FK506 to FKBP12, |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1200 |
Binding of FK506 to FKBP12, Formation |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1653 |
Binding of inhibitor to mitochondrial complex III |
Molecular |
Jun 7, 2019 |
Jun 7, 2019 |
- Mitochondrial complex inhibition leading to liver injury
|
1654 |
Binding of inhibitor to mitochondrial complex IV |
Molecular |
Jun 7, 2019 |
Jun 7, 2019 |
- Mitochondrial complex inhibition leading to liver injury
|
1655 |
Binding of inhibitor to mitochondrial complex V |
Molecular |
Jun 7, 2019 |
Jun 7, 2019 |
- Mitochondrial complex inhibition leading to liver injury
|
888 |
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) |
Molecular |
Nov 29, 2016 |
Mar 28, 2018 |
- Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
- Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
- Mitochondrial complex inhibition leading to liver injury
|
1580 |
Binding of microtubule stabilizing agents (MSA) to microtubules |
Molecular |
Jan 29, 2019 |
Jan 29, 2019 |
- Microtubule interacting drugs lead to peripheral neuropathy
|
1486 |
Binding of substrate, endocytic receptor |
Molecular |
Oct 25, 2017 |
Oct 25, 2017 |
- Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
|
1485 |
Binding of substrate, endocytotic receptor |
Molecular |
Oct 25, 2017 |
Oct 25, 2017 |
|
1252 |
Binding to (interferes with) topoisomerase II enzyme |
Molecular |
Dec 16, 2016 |
Aug 1, 2022 |
- Inhibitor binding to topoisomerase II leading to infant leukaemia
|
1739 |
Binding to ACE2 |
Molecular |
Mar 2, 2020 |
Oct 21, 2024 |
- Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
- Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
- Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
- Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
- SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
- Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)
- SARS-CoV-2 infection leading to hyperinflammation
- SARS-CoV-2 infection leading to pyroptosis
- SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
- ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
- Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption
- Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis
- Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
- Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
- Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
|
1710 |
Binding to estrogen receptor (ER)-α in immune cells |
Molecular |
Dec 29, 2019 |
Aug 14, 2020 |
- Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
|
1956 |
Binding to hERG channel |
Molecular |
Dec 13, 2021 |
Dec 13, 2021 |
|
1353 |
Binding to voltage-gated sodium channel |
Molecular |
Apr 14, 2017 |
Jul 31, 2024 |
- Molecular events lead to epilepsy
- presynaptic neuron 1 activation to epilepsy
- Binding to voltage gate sodium channels during development leads to cognitive impairment
- Inhibition of voltage-gated sodium channels leading to decreased cognition
|
977 |
Binding, Binding of calcineurin with FK506-FKBP complexes |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
2109 |
Binding, extracellular matrix protein laminin |
Molecular |
Feb 21, 2023 |
Feb 21, 2023 |
- Binding to the extracellular protein laminin leading to decreased cognitive function
|
1201 |
Binding, Immunophilins |
Molecular |
Nov 29, 2016 |
Oct 17, 2017 |
|
261 |
Binding, SH-/selen-proteins |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
|
1487 |
Binding, Thiol/seleno-proteins involved in protection against oxidative stress |
Molecular |
Nov 9, 2017 |
Jul 15, 2022 |
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
|
1831 |
Binding, Thyroid binding globulin in serum |
Molecular |
Dec 9, 2020 |
Dec 9, 2020 |
- Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
|
957 |
Binding, Transthyretin in serum |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
- Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
|
718 |
Binding, Tubulin |
Molecular |
Nov 29, 2016 |
Apr 20, 2021 |
- Chemical binding to tubulin in oocytes leading to aneuploid offspring
|
301 |
Binding, VEGF-A |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1716 |
Blockade of STAT5 phosphorylation |
Cellular |
Jan 5, 2020 |
Feb 15, 2021 |
- Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
|
1529 |
Blockade, L-Type Calcium Channels |
Molecular |
Jun 19, 2018 |
Nov 1, 2018 |
- L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
|
1570 |
Blocking of IL-1R |
Molecular |
Dec 24, 2018 |
Jun 1, 2019 |
|
1874 |
blood brain barrier disruption |
Cellular |
Apr 27, 2021 |
Apr 27, 2021 |
- Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)
|
1676 |
Blood extravasation into the lungs |
Organ |
Jul 3, 2019 |
Jul 3, 2019 |
|
1132 |
Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
|
1867 |
Bradykinin system, hyperactivated |
Molecular |
Apr 20, 2021 |
Jan 24, 2022 |
- Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
|
2093 |
Brain thyroid hormone (T4/T3) decreased |
Organ |
Jan 19, 2023 |
Jan 19, 2023 |
- Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
|
1588 |
Bronchiolitis obliterans |
Individual |
Jan 30, 2019 |
Jan 30, 2019 |
- α-diketone-induced bronchiolitis obliterans
|
1879 |
Bulky DNA adducts, increase |
Molecular |
May 17, 2021 |
May 17, 2021 |
- Bulky DNA adducts leading to mutations
|
1149 |
Calcium cannot bind to the hydroxyapatite matrix of bone, Osteocalcin and other bone proteins (periostin, MGP and periostin like factor) not formed |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
2001 |
Cardiac hypertrophy |
Organ |
Apr 22, 2022 |
Apr 22, 2022 |
|
2190 |
Cardiomyocyte differentiation inhibition |
Cellular |
Sep 16, 2023 |
Sep 16, 2023 |
|
2257 |
Celiac disease |
Individual |
Aug 13, 2024 |
Aug 13, 2024 |
- Gluten intake leading to celiac disease - under development
|
1505 |
Cell cycle, disrupted |
Cellular |
Jan 21, 2018 |
Jun 30, 2021 |
- Histone deacetylase inhibition leading to testicular atrophy
- AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation
- Deposition of ionizing energy leads to population decline via impaired meiosis
- Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage and reduced cell proliferation
- Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation
|
2103 |
Cellular dysfunction (human placenta trophoblast cells) |
Cellular |
Feb 7, 2023 |
Feb 7, 2023 |
|
429 |
Cellular Proliferation and Clonal Expansion of Mutant Cells (Pre-neoplastic Foci), Alteration of cellular growth homeostasis |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
2228 |
Cerebellar gene expression. Altered |
Molecular |
Jun 6, 2024 |
Jun 6, 2024 |
- Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function
|
2230 |
Cerebellar hypoplasia |
Tissue |
Jun 6, 2024 |
Jun 6, 2024 |
- Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function
|
2229 |
Cerebellar neuronal differentiation. Decreased |
Organ |
Jun 6, 2024 |
Jun 6, 2024 |
- Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function
|
1875 |
Cerebrovascular disease (stroke) |
Organ |
Apr 27, 2021 |
Mar 30, 2022 |
- Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)
|
853 |
Changes/Inhibition, Cellular Homeostasis and Apoptosis |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Sustained AhR Activation leading to Rodent Liver Tumours
|
1564 |
Chemical induced Fanconi syndrome |
Individual |
Dec 20, 2018 |
Dec 20, 2018 |
- Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
|
357 |
Cholestasis, Pathology |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
|
1454 |
chronic high fat diet |
Individual |
Jul 24, 2017 |
Jul 24, 2017 |
- Epigenetic modification of PPARG leading to adipogenesis
|
1603 |
Chronic kidney disease |
Organ |
Feb 18, 2019 |
Feb 18, 2019 |
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
- Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
|
1894 |
chronic low grade systemic inflammation |
Individual |
Jun 24, 2021 |
Jun 24, 2021 |
|
2008 |
Chronic obstructive pulmonary disease |
Individual |
May 31, 2022 |
May 31, 2022 |
- Adverse outcome pathway of PM-induced respiratory toxicity
|
1753 |
Chronic reactive oxygen species |
Molecular |
Mar 23, 2020 |
Nov 9, 2021 |
- Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
|
1251 |
Chronic, Mucus hypersecretion |
Tissue |
Nov 29, 2016 |
Aug 25, 2021 |
|
1908 |
Cilia Beat Frequency, Decreased |
Cellular |
Jul 19, 2021 |
Sep 10, 2021 |
- Oxidative stress Leading to Decreased Lung Function
- Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
- Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
|
491 |
Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
|
1845 |
Coagulation |
Organ |
Mar 25, 2021 |
Aug 30, 2023 |
- Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
|
402 |
Cognitive function, decreased |
Individual |
Nov 29, 2016 |
Jul 25, 2024 |
- Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
- Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
- Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
- Binding to the extracellular protein laminin leading to decreased cognitive function
- Unknown MIE altering cholesterol metabolism leading to decreased cognition
- Increased reactive oxygen species production leading to decreased cognitive function
- Inhibition of voltage-gated sodium channels leading to decreased cognition
- AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Binding to voltage gate sodium channels during development leads to cognitive impairment
|
2075 |
Cognitive, sensed as hypoxic/low oxygen environment |
Organ |
Nov 16, 2022 |
Nov 16, 2022 |
- Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
|
1275 |
Collagen Deposition |
Tissue |
Feb 15, 2017 |
Feb 15, 2017 |
- Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
|
1558 |
Collagen production, reduced |
Tissue |
Dec 20, 2018 |
Dec 20, 2018 |
- Histone deacetylase inhibition leads to impeded craniofacial development
|
1997 |
Colon epithelial injury |
Organ |
Apr 7, 2022 |
Apr 7, 2022 |
|
2101 |
Conformational changes of thyroid receptor |
Molecular |
Feb 7, 2023 |
Feb 7, 2023 |
|
2131 |
Conjugation, GSH |
Cellular |
Apr 5, 2023 |
Sep 14, 2023 |
- Glutathione conjugation leading to reproductive dysfunction via oxidative stress
|
1832 |
Coordinated gene expression changes by PPARα activation |
Molecular |
Dec 19, 2020 |
Dec 19, 2020 |
|
1835 |
Cortisol and 11β-(OH) testosterone decreased |
Cellular |
Feb 9, 2021 |
Feb 9, 2021 |
- Inhibition of 11β-hydroxylase leading to decresed population trajectory
|
1221 |
Cough, Dyspnea, Sneezing, Acute respiratory effect |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
396 |
Covalent Binding, Protein |
Molecular |
Nov 29, 2016 |
Nov 5, 2020 |
- Covalent Protein binding leading to Skin Sensitisation
- Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
|
1508 |
CYP2E1 Activation |
Molecular |
Mar 26, 2018 |
Apr 9, 2018 |
- CYP2E1 activation and formation of protein adducts leading to neurodegeneration
|
1386 |
CYP7B activity, inhibition |
Molecular |
May 2, 2017 |
May 17, 2017 |
- Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
- Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
|
1906 |
Cystic Fibrosis Transmembrane Regulator Function, Decreased |
Molecular |
Jul 19, 2021 |
Aug 3, 2021 |
- Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
|
2102 |
Cytotoxicity (human trophoblast cells) |
Cellular |
Feb 7, 2023 |
Feb 7, 2023 |
|
829 |
Damage, Lipid bilayer |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
|
250 |
Damaging, Red blood cells; hemolysis |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Oxidation of iron in hemoglobin leading to hematotoxicity
|
563 |
Death/Failure, Colony |
Population |
Nov 29, 2016 |
Jun 7, 2018 |
- Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
- Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
- Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure
- Suppression of immune system contributes to impaired development and leads to colony loss/failure
- Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
- Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
- Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
- Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
- Varroa mite infestation increases virus levels leading to colony loss/failure
- Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure
- Weather event contributes to colony loss/failure
- Weather event contributes abnormal foraging leading to colony loss/failure
- Nosema infection increases energetic demands leading to colony loss/failure
- Nosema infection causes abnormal role change that leads to colony loss/failure
- Queen egg-laying decrease leads to colony loss/failure
|
2200 |
decline, neural progenitor cells |
Organ |
Jan 10, 2024 |
Jan 10, 2024 |
- Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
|
361 |
Decline, Population |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Juvenile hormone receptor agonism leading to male offspring induction associated population decline
|
679 |
Decline, Population trajectory |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Luteinizing hormone receptor antagonism leading to reproductive dysfunction
|
1258 |
Decompartmentalization |
Cellular |
Feb 7, 2017 |
Sep 16, 2017 |
- AOP from chemical insult to cell death
|
1890 |
Decrease (loss of) fetal male germ cells |
Cellular |
May 29, 2021 |
Nov 11, 2021 |
- Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males
|
1545 |
Decrease in mitochondrial oxidative phosphorylation |
Cellular |
Dec 19, 2018 |
Dec 19, 2018 |
- Mitochondrial complex inhibition leading to liver injury
|
2215 |
Decrease Left Ventricular function |
Organ |
Apr 3, 2024 |
Apr 3, 2024 |
- Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
- Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
|
1696 |
Decrease of egg production and cummulative fecundity |
Individual |
Oct 3, 2019 |
Oct 3, 2019 |
- Luteinizing hormone receptor antagonism leading to reproductive dysfunction
- Deposition of ionizing energy leads to population decline via impaired meiosis
|
851 |
Decrease of GABAergic interneurons |
Cellular |
Nov 29, 2016 |
Apr 4, 2019 |
- Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
- Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory
|
386 |
Decrease of neuronal network function |
Organ |
Nov 29, 2016 |
May 28, 2018 |
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
- Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
- Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
- Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
- Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
- A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
- Excessive iron accumulation leading to neurological disorders
- Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
- Estrogen antagonism leading to increased risk of autism-like behavior
- Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory
|
385 |
Decrease of synaptogenesis |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
- Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
- Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory
|
425 |
Decrease of Thyroidal iodide |
Cellular |
Nov 29, 2016 |
Apr 4, 2019 |
- Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
- Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
- Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
|
2057 |
Decrease, hatching of egg |
Individual |
Aug 28, 2022 |
Aug 28, 2022 |
- Doda decarboxylase leading to mortality
|
2058 |
Decrease, 20-hydroxyecdysone |
Molecular |
Aug 28, 2022 |
Aug 28, 2022 |
- Knickkopf leading to mortality
|
993 |
Decrease, Abdominal muscle contraction |
Tissue |
Nov 29, 2016 |
May 24, 2018 |
- Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
|
1834 |
Decrease, Acyl-CoA dehydrogenases |
Molecular |
Jan 15, 2021 |
Jan 15, 2021 |
- Glucocorticoid Receptor activation leading to hepatic steatosis
|
1771 |
Decrease, Adenosine triphosphate pool |
Cellular |
Apr 30, 2020 |
Jun 14, 2021 |
- Excessive reactive oxygen species production leading to mortality (2)
- Excessive reactive oxygen species production leading to mortality (3)
- Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death
- Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
- Mitochondrial ATP synthase antagonism leading to growth inhibition (1)
- Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
- Mitochondrial complex III antagonism leading to growth inhibition (1)
- Mitochondrial complex III antagonism leading to growth inhibition (2)
- Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
- Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation
|
1614 |
Decrease, androgen receptor activation |
Tissue |
Apr 10, 2019 |
Apr 5, 2024 |
- Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
- 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring
- Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring
- Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
- Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring
- Androgen receptor antagonism leading to testicular cancer
- Androgen receptor (AR) antagonism leading to hypospadias in male offspring
- Androgen receptor (AR) antagonism leading to decreased fertility in females
|
914 |
Decrease, Apoptosis of ciliated epithelial cells |
Cellular |
Nov 29, 2016 |
Aug 17, 2021 |
|
35 |
Decrease, Aromatase (Cyp19a1) |
Cellular |
Nov 29, 2016 |
Nov 29, 2016 |
|
1966 |
Decrease, Asexual reproduction |
Individual |
Jan 17, 2022 |
Jan 17, 2022 |
|
1472 |
Decrease, ATP production |
Cellular |
Oct 10, 2017 |
Apr 11, 2021 |
- Reduction in photophosphorylation leading to growth inhibition in aquatic plants
- Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
- Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
|
1808 |
Decrease, ATP synthase activity |
Molecular |
Nov 2, 2020 |
Nov 2, 2020 |
|
1534 |
Decrease, Blood pressure |
Individual |
Jun 19, 2018 |
Jun 19, 2018 |
|
1531 |
Decrease, Calcium binding to Troponin C |
Cellular |
Jun 19, 2018 |
Jun 19, 2018 |
- L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
|
1530 |
Decrease, Calcium currents |
Cellular |
Jun 19, 2018 |
Jun 19, 2018 |
- L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
|
1532 |
Decrease, Cardiac contractility |
Organ |
Jun 19, 2018 |
Jun 19, 2018 |
- L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
- Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
- Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
|
1533 |
Decrease, Cardiac ejection fraction |
Organ |
Jun 19, 2018 |
Jun 19, 2018 |
- L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
|
1821 |
Decrease, Cell proliferation |
Cellular |
Nov 12, 2020 |
Dec 7, 2020 |
- Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
- Mitochondrial ATP synthase antagonism leading to growth inhibition (1)
- Mitochondrial complex III antagonism leading to growth inhibition (1)
- Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
- Antagonism of Smoothened receptor leading to orofacial clefting
- Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
- Decrease, GLI1/2 target gene expression leads to orofacial clefting
- Decrease, cholesterol synthesis leads to orofacial clefting
- Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage and reduced cell proliferation
- Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation
- Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation
|
2060 |
Decrease, Chitin laminar organization |
Tissue |
Aug 28, 2022 |
Aug 28, 2022 |
- Knickkopf leading to mortality
|
1473 |
Decrease, Chlorophyll synthesis |
Cellular |
Oct 10, 2017 |
Oct 10, 2017 |
- Reduction in photophosphorylation leading to growth inhibition in aquatic plants
|
1266 |
Decrease, Circulating crustacean cardioactive peptide |
Tissue |
Feb 9, 2017 |
May 24, 2018 |
- Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
|
988 |
Decrease, Circulating ecdysis triggering hormone |
Tissue |
Nov 29, 2016 |
May 24, 2018 |
- Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
|
1446 |
Decrease, Coupling of oxidative phosphorylation |
Molecular |
Jun 29, 2017 |
May 28, 2021 |
- Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
- Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
- Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death
- Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
- Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
- Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
- Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress
- Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation
|
1523 |
Decrease, Cuticular chitin content |
Tissue |
May 24, 2018 |
Feb 17, 2021 |
- S-adenosylmethionine depletion leading to population decline (2)
- S-adenosylmethionine depletion leading to population decline (1)
- Chitin synthase 1 inhibition leading to mortality
- Sulfonylureareceptor binding leading to mortality
|
1313 |
Decrease, cytosolic fatty acid |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
|
996 |
Decrease, Digestion of old cuticle |
Organ |
Nov 29, 2016 |
Oct 21, 2020 |
- Chitinase inhibition leading to mortality
- Chitobiase inhibition leading to mortality
|
1613 |
Decrease, dihydrotestosterone (DHT) level |
Tissue |
Apr 10, 2019 |
Apr 5, 2024 |
- Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
- Inhibition of 5α-reductase leading to impaired fecundity in female fish
- 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring
- Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
|
2052 |
Decrease, dopa decarboxylase |
Cellular |
Aug 28, 2022 |
Aug 28, 2022 |
- Doda decarboxylase leading to mortality
|
1056 |
Decrease, E2 blood concentrations at hypothalamus |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
|
1267 |
Decrease, Ecdysis motoneuron bursts |
Tissue |
Feb 9, 2017 |
May 24, 2018 |
- Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
|
2196 |
Decrease, elavl3 |
Molecular |
Oct 17, 2023 |
Oct 17, 2023 |
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1268 |
Decrease, Excitatory postsynaptic potential |
Tissue |
Feb 9, 2017 |
May 24, 2018 |
- Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
|
1699 |
Decrease, expression of gonadotropin releasing hormone receptor |
Molecular |
Oct 30, 2019 |
Oct 30, 2019 |
- Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
|
1824 |
Decrease, Fatty acid β-oxidation |
Cellular |
Nov 25, 2020 |
Nov 25, 2020 |
|
328 |
Decrease, Fecundity |
Individual |
Nov 29, 2016 |
Jun 12, 2018 |
- DNA methyltransferase inhibition leading to population decline (1)
- DNA methyltransferase inhibition leading to population decline (2)
- DNA methyltransferase inhibition leading to population decline (3)
- DNA methyltransferase inhibition leading to population decline (4)
- Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
|
1781 |
Decrease, Fecundity (F3) |
Individual |
Apr 30, 2020 |
Apr 30, 2020 |
- DNA methyltransferase inhibition leading to transgenerational effects (1)
- DNA methyltransferase inhibition leading to transgenerational effects (2)
|
330 |
Decrease, Fertility |
Individual |
Nov 29, 2016 |
Jun 29, 2017 |
- HMG-CoA reductase inhibition leading to decreased fertility
|
2040 |
Decrease, GLI1/2 target gene expression |
Cellular |
Jul 25, 2022 |
Mar 22, 2023 |
- Antagonism of Smoothened receptor leading to orofacial clefting
- Decrease, GLI1/2 target gene expression leads to orofacial clefting
- Decrease, cholesterol synthesis leads to orofacial clefting
|
2028 |
Decrease, GLI1/2 translocation to nucleus |
Molecular |
Jul 15, 2022 |
Oct 28, 2022 |
- Antagonism of Smoothened receptor leading to orofacial clefting
- Decrease, cholesterol synthesis leads to orofacial clefting
|
1773 |
Decrease, Global DNA methylation |
Molecular |
Apr 30, 2020 |
Apr 30, 2020 |
- DNA methyltransferase inhibition leading to population decline (1)
- DNA methyltransferase inhibition leading to population decline (2)
- DNA methyltransferase inhibition leading to transgenerational effects (1)
- DNA methyltransferase inhibition leading to transgenerational effects (2)
|
2071 |
Decrease, Glucose pool |
Cellular |
Nov 1, 2022 |
Nov 1, 2022 |
- Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
|
1951 |
Decrease, Glucose uptake |
Cellular |
Nov 18, 2021 |
Nov 18, 2021 |
- Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
|
1949 |
Decrease, GLUT4 |
Cellular |
Nov 18, 2021 |
Nov 18, 2021 |
- Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
|
1476 |
Decrease, Glycolysis |
Cellular |
Oct 10, 2017 |
Oct 10, 2017 |
- Reduction in photophosphorylation leading to growth inhibition in aquatic plants
|
1521 |
Decrease, Growth |
Individual |
May 24, 2018 |
Jul 6, 2022 |
- Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
- Mitochondrial ATP synthase antagonism leading to growth inhibition (1)
- Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
- Mitochondrial complex III antagonism leading to growth inhibition (1)
- Mitochondrial complex III antagonism leading to growth inhibition (2)
- Reduction in photophosphorylation leading to growth inhibition in aquatic plants
- Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
- Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death
- Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
- Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
- Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
- Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
- Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death
- Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death
- Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell death
- Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage and reduced cell proliferation
- Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation
- Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation
|
1778 |
Decrease, Heritable DNA methylation (F3) |
Molecular |
Apr 30, 2020 |
Apr 30, 2020 |
- DNA methyltransferase inhibition leading to transgenerational effects (1)
- DNA methyltransferase inhibition leading to transgenerational effects (2)
|
633 |
Decrease, histaminergic neuron excitation |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Histamine (H2) receptor antagonism leading to reduced survival
|
788 |
Decrease, Incorporation of active iodide into iodotyrosines |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
|
867 |
Decrease, Intracellular pH |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
|
2059 |
Decrease, knickkopf gene |
Cellular |
Aug 28, 2022 |
Aug 28, 2022 |
- Knickkopf leading to mortality
|
1478 |
Decrease, Leaf cell mitosis |
Tissue |
Oct 10, 2017 |
Oct 10, 2017 |
- Reduction in photophosphorylation leading to growth inhibition in aquatic plants
|
1479 |
Decrease, Leaf development |
Organ |
Oct 10, 2017 |
Oct 10, 2017 |
- Reduction in photophosphorylation leading to growth inhibition in aquatic plants
- Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
|
1377 |
Decrease, leukocyte adherence |
Tissue |
Apr 17, 2017 |
Apr 17, 2017 |
|
1474 |
Decrease, Light harvest capacity |
Cellular |
Oct 10, 2017 |
Oct 10, 2017 |
- Reduction in photophosphorylation leading to growth inhibition in aquatic plants
|
1250 |
Decrease, Lung function |
Individual |
Nov 29, 2016 |
Sep 8, 2021 |
- EGFR Activation Leading to Decreased Lung Function
- Lung surfactant function inhibition leading to decreased lung function
- Oxidative stress Leading to Decreased Lung Function
- Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway
- Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway
- Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
- Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
|
2198 |
Decrease, mbp |
Molecular |
Oct 17, 2023 |
Oct 17, 2023 |
- Various neuronal effects induced by elavl3, sox10, and mbp
|
40 |
Decrease, Mitochondrial ATP production |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Calcium-mediated neuronal ROS production and energy imbalance
- Reduction in photophosphorylation leading to growth inhibition in aquatic plants
- Renal protein alkylation leading to kidney toxicity
- Deposition of ionising energy leading to population decline via mitochondrial dysfunction
- Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
|
1770 |
Decrease, Mitochondrial membrane potential |
Cellular |
Apr 30, 2020 |
Apr 30, 2020 |
- Excessive reactive oxygen species production leading to mortality (2)
- Deposition of ionising energy leading to population decline via mitochondrial dysfunction
- Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
|
2063 |
Decrease, New cuticle secretion |
Organ |
Aug 28, 2022 |
Aug 28, 2022 |
- Knickkopf leading to mortality
|
572 |
Decrease, Number of worker bees |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
- Suppression of immune system contributes to impaired development and leads to colony loss/failure
- Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
- Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
|
1366 |
Decrease, Oogenesis |
Organ |
Apr 15, 2017 |
Apr 30, 2020 |
- DNA methyltransferase inhibition leading to population decline (1)
- DNA methyltransferase inhibition leading to population decline (2)
- DNA methyltransferase inhibition leading to population decline (3)
- DNA methyltransferase inhibition leading to population decline (4)
- Deposition of energy leading to population decline via DNA strand breaks and follicular atresia
- Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis
- Deposition of energy leading to population decline via DNA oxidation and follicular atresia
- Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
- Deposition of ionizing energy leads to population decline via impaired meiosis
|
1782 |
Decrease, Oogenesis (F3) |
Organ |
Apr 30, 2020 |
Apr 30, 2020 |
- DNA methyltransferase inhibition leading to transgenerational effects (1)
- DNA methyltransferase inhibition leading to transgenerational effects (2)
|
488 |
Decrease, Ovulation |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading to reproductive dysfunction
|
1477 |
Decrease, Oxidative phosphorylation |
Cellular |
Oct 10, 2017 |
Dec 20, 2018 |
- Reduction in photophosphorylation leading to growth inhibition in aquatic plants
- Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
- Excessive reactive oxygen species production leading to mortality (2)
- Deposition of ionising energy leading to population decline via mitochondrial dysfunction
|
2041 |
Decrease, palatal shelf outgrowth |
Tissue |
Jul 27, 2022 |
May 16, 2023 |
- Antagonism of Smoothened receptor leading to orofacial clefting
- Decrease, GLI1/2 target gene expression leads to orofacial clefting
- Decrease, cholesterol synthesis leads to orofacial clefting
|
1475 |
Decrease, Photosynthesis |
Cellular |
Oct 10, 2017 |
Oct 10, 2017 |
- Reduction in photophosphorylation leading to growth inhibition in aquatic plants
- Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
- Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
|
1517 |
Decrease, Photosystem II activity |
Molecular |
May 24, 2018 |
Oct 7, 2020 |
|
1862 |
Decrease, Photosystem II efficiency |
Cellular |
Apr 11, 2021 |
Apr 11, 2021 |
- Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
- Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
|
1810 |
Decrease, Plasma membrane ATPase activity |
Cellular |
Nov 2, 2020 |
Nov 2, 2020 |
|
360 |
Decrease, Population growth rate |
Population |
Nov 29, 2016 |
Jan 3, 2023 |
- Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
- Aromatase inhibition leading to reproductive dysfunction
- Estrogen receptor agonism leading to reproductive dysfunction
- Estrogen receptor antagonism leading to reproductive dysfunction
- Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
- Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
- Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
- Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
- Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
- Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
- Cyclooxygenase inhibition leading to reproductive dysfunction
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
- Inhibition of tyrosinase leads to decreased population in fish
- Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
- Acetylcholinesterase inhibition leading to acute mortality
- Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
- Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
- DNA methyltransferase inhibition leading to population decline (1)
- DNA methyltransferase inhibition leading to population decline (2)
- DNA methyltransferase inhibition leading to population decline (3)
- DNA methyltransferase inhibition leading to population decline (4)
- DNA methyltransferase inhibition leading to transgenerational effects (1)
- DNA methyltransferase inhibition leading to transgenerational effects (2)
- Inhibition of 5α-reductase leading to impaired fecundity in female fish
- Inhibition of retinaldehyde dehydrogenase leads to population decline
- Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
- Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
- Inhibition of 11β-hydroxylase leading to decresed population trajectory
- Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
- Androgen receptor agonism leading to male-biased sex ratio
- Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
- Deposition of ionising energy leading to population decline via mitochondrial dysfunction
- Deposition of ionising energy leading to population decline via programmed cell death
- Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
- Thyroperoxidase inhibition leading to altered visual function via decreased eye size
- Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
- Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
- GSK3beta inactivation leading to increased mortality via defects in developing inner ear
- Deposition of energy leading to population decline via DNA strand breaks and follicular atresia
- Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis
- Deposition of energy leading to population decline via DNA oxidation and follicular atresia
- Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
- Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
- Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
- Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
- 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
- Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
- Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
- PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
- Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
- Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
|
2061 |
Decrease, Prevent chitin degradation by chitinases |
Tissue |
Aug 28, 2022 |
Aug 28, 2022 |
- Knickkopf leading to mortality
|
1863 |
Decrease, Reproduction |
Individual |
Apr 11, 2021 |
Apr 11, 2021 |
- Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
- Deposition of ionising energy leading to population decline via mitochondrial dysfunction
- Deposition of ionising energy leading to population decline via programmed cell death
- Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
- Deposition of ionizing energy leads to population decline via impaired meiosis
- Deposition of ionising energy leads to population decline via pollen abnormal
- Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
|
771 |
Decrease, Serum thyroid hormone (T4/T3) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
|
2044 |
Decrease, Smoothend relocation and activation |
Cellular |
Aug 23, 2022 |
Oct 27, 2022 |
- Antagonism of Smoothened receptor leading to orofacial clefting
|
2043 |
Decrease, Sonic Hedgehog second messenger production |
Cellular |
Aug 12, 2022 |
Mar 22, 2023 |
- Antagonism of Smoothened receptor leading to orofacial clefting
- Decrease, GLI1/2 target gene expression leads to orofacial clefting
- Decrease, cholesterol synthesis leads to orofacial clefting
|
2197 |
Decrease, sox10 |
Molecular |
Oct 17, 2023 |
Oct 17, 2023 |
- Various neuronal effects induced by elavl3, sox10, and mbp
|
2020 |
Decrease, sox9 expression |
Molecular |
Jun 28, 2022 |
Sep 25, 2024 |
- Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
- Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
|
266 |
Decrease, Steroidogenic acute regulatory protein (STAR) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARα activation in utero leading to impaired fertility in males
|
1382 |
Decrease, surfactant |
Molecular |
Apr 17, 2017 |
Apr 17, 2017 |
- Gastric ulcer formation
- Helicobacter pylori to gastric ulcer
|
1690 |
Decrease, testosterone levels |
Tissue |
Aug 30, 2019 |
May 24, 2024 |
- Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
- Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
- HMG-CoA reductase inhibition leading to decreased fertility
- PPARα activation in utero leading to impaired fertility in males
- PPARα activation leading to impaired fertility in adult male rodents
- Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
- Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
- Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
- Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
|
1687 |
decrease, transcription of genes by AR |
Cellular |
Aug 30, 2019 |
Aug 30, 2019 |
- Androgen receptor antagonism leading to testicular cancer
|
1622 |
Decrease, Transgenerational DNA methylation |
Molecular |
Apr 22, 2019 |
Apr 22, 2019 |
|
289 |
Decrease, Translocator protein (TSPO) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARα activation in utero leading to impaired fertility in males
|
1772 |
Decrease, Triglyceride |
Cellular |
Apr 30, 2020 |
May 27, 2024 |
- Excessive reactive oxygen species production leading to mortality (3)
|
2051 |
Decrease, Tyrosine |
Molecular |
Aug 28, 2022 |
Aug 28, 2022 |
- Doda decarboxylase leading to mortality
|
642 |
Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
|
646 |
Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis |
Organ |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
|
645 |
Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
|
644 |
Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
|
643 |
Decreased Cholesterol, Decreased Uptake of Lipoproteins |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
|
1452 |
decreased DNA methylation of tyrosine hydroxylase |
Cellular |
Jul 24, 2017 |
Jul 24, 2017 |
- Epigenetic modification of PPARG leading to adipogenesis
|
1450 |
decreased dopamine |
Molecular |
Jul 24, 2017 |
Jul 24, 2017 |
- Epigenetic modification of PPARG leading to adipogenesis
|
2176 |
Decreased endothelial cell proliferation |
Cellular |
Aug 21, 2023 |
Aug 21, 2023 |
|
543 |
Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
|
972 |
Decreased fertility, Reduced number of oocytes ovulated |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
|
2026 |
decreased folate uptake |
Cellular |
Jul 14, 2022 |
Jul 14, 2022 |
- Ceramide synthase inhibition leading to neural tube defects
|
969 |
Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
|
1571 |
Decreased IL-1 production |
Cellular |
Dec 24, 2018 |
Jun 24, 2019 |
|
968 |
Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
|
970 |
Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
|
1453 |
decreased methylation of dopamine transporter promoter |
Cellular |
Jul 24, 2017 |
Jul 24, 2017 |
- Epigenetic modification of PPARG leading to adipogenesis
|
1751 |
Decreased mortality |
Individual |
Mar 17, 2020 |
Mar 17, 2020 |
|
1562 |
Decreased Na/K ATPase activity |
Cellular |
Dec 20, 2018 |
Oct 25, 2024 |
- Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
- Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
- Na+ /K+ -ATPase inhibition leading to hypertension
- Decreased Sodium/Potassium ATPase activity leads to Heart failure
|
1837 |
decreased oocyte maturation |
Organ |
Feb 9, 2021 |
Feb 9, 2021 |
- Inhibition of 11β-hydroxylase leading to decresed population trajectory
|
1836 |
Decreased plasma Cortisol level |
Tissue |
Feb 9, 2021 |
Feb 9, 2021 |
- Inhibition of 11β-hydroxylase leading to decresed population trajectory
|
1642 |
Decreased plasma RA level |
Tissue |
May 22, 2019 |
May 22, 2019 |
- Inhibition of retinaldehyde dehydrogenase leads to population decline
|
967 |
Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus |
Organ |
Nov 29, 2016 |
Dec 3, 2016 |
- Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
|
2203 |
Decreased proliferation of cortical neural progenitor cells |
Cellular |
Jan 14, 2024 |
Jan 29, 2024 |
- Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory
- Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
|
1538 |
Decreased protection against oxidative stress |
Cellular |
Sep 13, 2018 |
Jul 15, 2022 |
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
|
1563 |
Decreased proximal tubular vectorial transport |
Tissue |
Dec 20, 2018 |
Dec 20, 2018 |
- Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
|
1641 |
Decreased retinoic acid (RA) synthesis |
Cellular |
May 22, 2019 |
May 22, 2019 |
- Inhibition of retinaldehyde dehydrogenase leads to population decline
|
1451 |
decreased reward |
Individual |
Jul 24, 2017 |
Jul 24, 2017 |
- Epigenetic modification of PPARG leading to adipogenesis
|
1981 |
Decreased SIRT1 expression |
Cellular |
Mar 22, 2022 |
Mar 24, 2022 |
- DNA damage and mutations leading to Metastatic Breast Cancer
|
2140 |
Decreased spawning and cumulative fecundity, decreased gonadosomatic index |
Individual |
May 16, 2023 |
May 16, 2023 |
|
505 |
Decreased sperm quantity / quality in the adult, Decreased fertility |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
- Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
- Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
|
520 |
Decreased sperm quantity or quality in the adult, Decreased fertility |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
- Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
- Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
|
1798 |
Decreased spermatogenesis |
Organ |
Jul 13, 2020 |
Feb 9, 2021 |
- Inhibition of 11β-hydroxylase leading to decresed population trajectory
- Deposition of ionizing energy leads to population decline via impaired meiosis
- Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
|
649 |
Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
|
648 |
Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
|
640 |
Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
|
660 |
decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
|
659 |
Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
|
654 |
Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
|
661 |
Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
|
541 |
Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
|
657 |
Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells |
Organ |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
- Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
|
540 |
Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells |
Organ |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
|
662 |
Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
|
653 |
Decreased testosterone by the fetal Leydig cells, Increased corticosterone |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
|
655 |
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
- Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
- Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
- Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
|
658 |
Decreased testosterone by the fetal Leydig cells, Increased estradiol |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
|
1756 |
Decreased, plasma 11-ketotestosterone level |
Tissue |
Mar 23, 2020 |
May 24, 2022 |
- PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
- Inhibition of 11β-hydroxylase leading to decresed population trajectory
- Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
|
8 |
Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
|
1401 |
Decreased, 5-HT3 |
Tissue |
Jun 1, 2017 |
Jun 1, 2017 |
- Serotonin transporter activation to seizure
|
1881 |
Decreased, all-trans retinoic acid (atRA) concentration |
Tissue |
May 24, 2021 |
Feb 13, 2023 |
- Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary
- Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
|
1987 |
Decreased, Androgen and Progestin |
Cellular |
Apr 5, 2022 |
Jun 6, 2022 |
- Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
|
742 |
Decreased, Androgen receptor activity |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
|
1409 |
Decreased, angiogenesis |
Tissue |
Jun 2, 2017 |
Jun 2, 2017 |
- NSAID induced PTGS2 inactivation to gastric ulcer
|
627 |
Decreased, anxiety |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
|
1183 |
Decreased, Apoptosis (Epithelial Cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Estrogen receptor activation leading to breast cancer
- Androgen receptor activation leading to prostate cancer
|
800 |
Decreased, Aromatase (Cyp19a1) mRNA |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
- Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
|
2123 |
decreased, Bcl-2 expression |
Molecular |
Apr 4, 2023 |
Sep 7, 2023 |
- Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
|
1407 |
Decreased, bicarbonate |
Tissue |
Jun 2, 2017 |
Jun 2, 2017 |
- NSAID induced PTGS1 inactivation to gastric ulcer
|
1058 |
Decreased, bile flow |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
|
848 |
Decreased, Binding of NE to NE receptors on GnRH neurons |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
|
2261 |
Decreased, blood plasma volume |
Tissue |
Sep 20, 2024 |
Sep 26, 2024 |
- Decreased Sodium/Potassium ATPase activity leads to Heart failure
|
315 |
Decreased, Body length |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
864 |
Decreased, Body Weight |
Individual |
Nov 29, 2016 |
Apr 30, 2019 |
- Antagonist binding to PPARα leading to body-weight loss
|
52 |
Decreased, Calcium influx |
Cellular |
Nov 29, 2016 |
Jun 13, 2018 |
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
|
656 |
Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) |
Cellular |
Nov 29, 2016 |
Jun 6, 2024 |
- Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
- Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
- Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
- Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
- Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
|
1178 |
Decreased, Chloride conductance |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
807 |
Decreased, cholesterol |
Tissue |
Nov 29, 2016 |
May 24, 2022 |
- HMG-CoA reductase inhibition leading to decreased fertility
- PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
|
533 |
Decreased, Cortical granule release/distribution upon fertilization |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
- Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
|
527 |
Decreased, Decreased fecundity |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
- Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
|
482 |
Decreased, DHB4/HSD17B4 |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NFE2L2/FXR activation leading to hepatic steatosis
|
1083 |
Decreased, Dopaminergic activity |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
|
2233 |
Decreased, ERαβ heterodimers |
Molecular |
Jun 19, 2024 |
Jun 19, 2024 |
- Binding and activation of GPER leading to learning and memory impairments
|
1319 |
Decreased, extracellular chloride (Cl-) |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
|
1347 |
Decreased, extracellular serotonin |
Molecular |
Apr 14, 2017 |
May 31, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Mental stress to depression
- Mental stress to agitation
- Serotonin transporter activation to seizure
- Serotonin transporter activation to depression
- Serotonin transporter activation to agitation
- SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
1318 |
Decreased, extracellular sodium (Na+) |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
|
1878 |
Decreased, Eye size |
Organ |
May 11, 2021 |
Jun 24, 2021 |
- Thyroperoxidase inhibition leading to altered visual function via decreased eye size
- Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
|
1414 |
Decreased, GABA |
Cellular |
Jun 2, 2017 |
Jun 2, 2017 |
- presynaptic neuron 2 repression to epilepsy
|
1179 |
Decreased, GABA release |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Sodium channel (Nav1.1) inhibition leading to population decline
|
1145 |
Decreased, gametogenesis |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
819 |
Decreased, Glomerular filtration |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Kidney dysfunction by decreased thyroid hormone
|
578 |
Decreased, Glucose oxidase enzyme activity |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
|
529 |
Decreased, GnRH cfos activity |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
- Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
|
530 |
Decreased, GnRH pulsatility/release |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
- Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
|
1071 |
Decreased, GnRH pulsatility/release in hypothalamus |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
- GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
|
1986 |
Decreased, Gonadotropins |
Molecular |
Apr 5, 2022 |
Apr 5, 2022 |
- Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
|
140 |
Decreased, HSD17B10 expression |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
|
579 |
Decreased, Hydrogen peroxide production |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
|
2268 |
Decreased, insulin-induced gene 1 (INSIG1) protein activity |
Cellular |
Oct 22, 2024 |
Oct 22, 2024 |
- Activation, Pregnane-X receptor, NR1l2 leads to Increased, plasma low-density lipoprotein (LDL) cholesterol
|
2214 |
Decreased, Insulin-like peptide 3 (INSL3) |
Molecular |
Mar 19, 2024 |
Jul 18, 2024 |
- Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis
|
2121 |
decreased, Intellectual Quotient |
Population |
Apr 4, 2023 |
Apr 4, 2023 |
- Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
|
1416 |
Decreased, intracellular chloride |
Cellular |
Jun 2, 2017 |
Jun 2, 2017 |
- presynaptic neuron 2 repression to epilepsy
|
1323 |
Decreased, intracellular serotonin |
Molecular |
Apr 13, 2017 |
May 31, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Mental stress to depression
- Mental stress to agitation
- SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
1177 |
Decreased, Ionotropic GABA receptor chloride channel conductance |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Various neuronal effects induced by elavl3, sox10, and mbp
|
477 |
Decreased, Ketogenesis |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
|
861 |
Decreased, Ketogenesis (production of ketone bodies) |
Cellular |
Nov 29, 2016 |
Apr 30, 2019 |
- Antagonist binding to PPARα leading to body-weight loss
|
531 |
Decreased, LH Surge |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
- Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
- Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level
|
1072 |
Decreased, LH Surge from anterior pituitary |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
- GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
|
635 |
Decreased, locomotion |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Histamine (H2) receptor antagonism leading to reduced survival
|
166 |
Decreased, Long-term potentiation (LTP) |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Calcium-mediated neuronal ROS production and energy imbalance
|
168 |
Decreased, Lymphocytes |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
|
1988 |
Decreased, Maturation Inducing Steroid Surge by Granulosa cells |
Tissue |
Apr 5, 2022 |
Apr 5, 2022 |
- Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
|
805 |
Decreased, mevalonate |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- HMG-CoA reductase inhibition leading to decreased fertility
|
860 |
Decreased, Mitochondrial Fatty Acid Beta Oxidation |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Glucocorticoid Receptor activation leading to hepatic steatosis
|
179 |
Decreased, Mitochondrial fatty acid beta-oxidation |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
- NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
- ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
- Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
|
1404 |
Decreased, mucosal blood flow |
Tissue |
Jun 2, 2017 |
Jun 2, 2017 |
- NSAID induced PTGS1 inactivation to gastric ulcer
|
1406 |
Decreased, mucous |
Tissue |
Jun 2, 2017 |
Jun 2, 2017 |
- NSAID induced PTGS1 inactivation to gastric ulcer
|
2105 |
Decreased, myelin basic protein expression in oligodendrocytes |
Molecular |
Feb 21, 2023 |
Feb 21, 2023 |
- Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
|
2111 |
Decreased, neural progenitor cell adhesion to laminin |
Cellular |
Feb 21, 2023 |
Feb 21, 2023 |
- Binding to the extracellular protein laminin leading to decreased cognitive function
|
618 |
Decreased, Neuronal network function in adult brain |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
- Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1330 |
Decreased, neuroplasticity |
Molecular |
Apr 13, 2017 |
May 31, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Mental stress to depression
- Mental stress to agitation
- Serotonin transporter activation to agitation
- Serotonin transporter activation to depression
|
193 |
Decreased, Nitric Oxide |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Calcium-mediated neuronal ROS production and energy imbalance
|
2116 |
Decreased, oligodendrocyte differentiation |
Cellular |
Feb 22, 2023 |
Feb 22, 2023 |
- Unknown MIE altering cholesterol metabolism leading to decreased cognition
- Increased reactive oxygen species production leading to decreased cognitive function
- Inhibition of voltage-gated sodium channels leading to decreased cognition
|
1045 |
Decreased, Ovarian E2 |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
|
2074 |
Decreased, oxygen binding capacity by hemocyanin |
Molecular |
Nov 16, 2022 |
Nov 16, 2022 |
- Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
|
1324 |
Decreased, packaged serotonin |
Molecular |
Apr 13, 2017 |
May 31, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Mental stress to depression
- Mental stress to agitation
- SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
216 |
Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- AhR activation leading to hepatic steatosis
|
859 |
Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
|
2237 |
Decreased, Plasma sodium concentrations |
Tissue |
Jul 8, 2024 |
Sep 26, 2024 |
- Decreased Sodium/Potassium ATPase activity leads to Heart failure
|
765 |
Decreased, population 1 |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Glutamate-gated chloride channel activation leading to acute mortality
|
992 |
Decreased, Population 2 |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
997 |
Decreased, Population size |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Deposition of ionizing energy leads to population decline via impaired meiosis
|
442 |
Decreased, Population trajectory |
Population |
Nov 29, 2016 |
Apr 18, 2017 |
- Deposition of ionising energy leads to population decline via pollen abnormal
- Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
|
231 |
Decreased, PPAR-alpha activation |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
|
232 |
Decreased, PPAR-beta activation |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
|
233 |
Decreased, PPAR-gamma activation |
Molecular |
Nov 29, 2016 |
Oct 30, 2023 |
- Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
- Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
|
858 |
Decreased, PPARalpha transactivation of gene expression |
Molecular |
Nov 29, 2016 |
Apr 30, 2019 |
- Antagonist binding to PPARα leading to body-weight loss
|
749 |
Decreased, Progesterone from corpus luteum |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
|
747 |
Decreased, Prolactin |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
|
1104 |
Decreased, Prostaglandin F2alpha concentration, plasma |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
|
681 |
Decreased, Prostaglandin F2alpha synthesis, ovary |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
|
2113 |
Decreased, radial glia cell density |
Cellular |
Feb 21, 2023 |
Feb 21, 2023 |
- Binding to the extracellular protein laminin leading to decreased cognitive function
|
1055 |
Decreased, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
825 |
Decreased, Renal ability to dilute urine |
Organ |
Nov 29, 2016 |
Dec 3, 2016 |
- Kidney dysfunction by decreased thyroid hormone
|
820 |
Decreased, Renal plasma flow |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Kidney dysfunction by decreased thyroid hormone
|
1141 |
Decreased, Reproductive Success |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
- Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
- Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
- Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
|
1327 |
Decreased, seizure |
Individual |
Apr 13, 2017 |
Apr 13, 2017 |
|
1317 |
Decreased, serotonin transporter activity |
Molecular |
Apr 13, 2017 |
May 31, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Mental stress to depression
- Mental stress to agitation
- SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
1022 |
Decreased, serum T4/T3 |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
|
629 |
Decreased, sheltering |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
|
585 |
Decreased, Sodium conductance 1 |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Sodium channel inhibition leading to reduced survival
- sodium channel inhibition leading to increased predation
- Sodium channel inhibition leading to congenital malformations
- Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
|
1176 |
Decreased, sodium conductance 2 |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Sodium channel (Nav1.1) inhibition leading to population decline
|
821 |
Decreased, Sodium reabsorption |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Kidney dysfunction by decreased thyroid hormone
|
2236 |
Decreased, Sodium uptake in gills |
Cellular |
Jul 8, 2024 |
Sep 24, 2024 |
- Decreased Sodium/Potassium ATPase activity leads to Heart failure
|
647 |
Decreased, steroidogenic protein expression |
Cellular |
Nov 29, 2016 |
Jul 16, 2024 |
- Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
- Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
- Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
|
636 |
Decreased, survival |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Histamine (H2) receptor antagonism leading to reduced survival
- Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
|
1325 |
Decreased, synaptic release |
Molecular |
Apr 13, 2017 |
May 31, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Mental stress to depression
- Mental stress to agitation
- SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
989 |
Decreased, synthesis and secretion of molting fluid proteases |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
994 |
Decreased, Synthesis of molting fluid proteases |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
|
528 |
Decreased, Synthesis of NE |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
|
743 |
Decreased, Testosterone binding to androgen receptor (hypothalamus) |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
|
2104 |
Decreased, thyroid hormone binding to thyroid hormone receptor |
Molecular |
Feb 21, 2023 |
Feb 21, 2023 |
- Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
|
1093 |
Decreased, Thyroxine (T4) in tissues |
Tissue |
Nov 29, 2016 |
Sep 3, 2020 |
|
1003 |
Decreased, Triiodothyronine (T3) |
Tissue |
Nov 29, 2016 |
Oct 7, 2022 |
- Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
- Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
- Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
- Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
- Thyroperoxidase inhibition leading to altered visual function via decreased eye size
- Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
|
1116 |
Decreased, Triiodothyronine (T3) in tissues |
Tissue |
Nov 29, 2016 |
Sep 1, 2020 |
- Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
- Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
|
737 |
Decreased, Uptake of inorganic iodide |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
|
304 |
Decreased, VegfR2 |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
2147 |
Decreased, Viable Offspring |
Individual |
Jun 2, 2023 |
Apr 10, 2024 |
- PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
- Essential element imbalance leads to reproductive failure via oxidative stress
|
1295 |
Defect of Embryogenesis |
Tissue |
Feb 15, 2017 |
Sep 16, 2017 |
- Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
|
890 |
Degeneration of dopaminergic neurons of the nigrostriatal pathway |
Organ |
Nov 29, 2016 |
Mar 15, 2018 |
- Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
- Various neuronal effects induced by elavl3, sox10, and mbp
|
428 |
Delay, Developmental GABA shift |
Cellular |
Nov 29, 2016 |
Nov 29, 2016 |
|
2047 |
Delay, Ovarian maturation |
Cellular |
Aug 28, 2022 |
Aug 28, 2022 |
- Alcohol dehydrogenase leading to reproductive dysfunction
|
2267 |
Delayed neuropathy, increased |
Individual |
Oct 1, 2024 |
Oct 1, 2024 |
- Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration
- Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
|
532 |
Delayed, Ovulation |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
- Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
|
1140 |
Delayed, Sexual maturity |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
|
2266 |
Demyelination, increased |
Cellular |
Oct 1, 2024 |
Oct 1, 2024 |
- Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration
- Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
|
2142 |
Depletion, Ectoplasmic specialization (ES) |
Cellular |
May 17, 2023 |
May 17, 2023 |
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
|
1143 |
Depletion, energy reserves |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
|
130 |
Depletion, GSH |
Cellular |
Nov 29, 2016 |
Sep 14, 2023 |
- Glutathione conjugation leading to reproductive dysfunction via oxidative stress
|
1482 |
Depletion, mtDNA |
Cellular |
Oct 25, 2017 |
Oct 25, 2017 |
- Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
|
1686 |
Deposition of Energy |
Molecular |
Aug 22, 2019 |
Aug 23, 2024 |
- Deposition of energy leading to lung cancer
- Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
- Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
- Deposition of ionising energy leading to population decline via mitochondrial dysfunction
- Deposition of ionising energy leading to population decline via programmed cell death
- Deposition of ionising energy leads to population decline via pollen abnormal
- Deposition of energy leading to population decline via DNA strand breaks and follicular atresia
- Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis
- Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
- Deposition of energy leading to population decline via DNA oxidation and follicular atresia
- Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
- Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
- Deposition of energy leads to abnormal vascular remodeling
- Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
- Deposition of energy leading to occurrence of cataracts
- Deposition of energy leading to occurrence of bone loss
- Deposition of Energy Leading to Learning and Memory Impairment
|
1550 |
Deposition of Ionizing Energy |
Molecular |
Dec 19, 2018 |
Dec 13, 2021 |
- Deposition of ionizing energy leads to population decline via impaired meiosis
|
663 |
Desensitization, Nicotinic acetylcholine receptor |
Molecular |
Nov 29, 2016 |
Jun 7, 2018 |
- Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
- Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
|
2189 |
Development-related pathway alterations |
Cellular |
Sep 16, 2023 |
Sep 17, 2023 |
|
2035 |
development, liver cancer |
Tissue |
Jul 21, 2022 |
Jul 21, 2022 |
|
1272 |
Differentiation of Myofibroblast |
Cellular |
Feb 15, 2017 |
Feb 15, 2017 |
|
2273 |
Dihydrotestosterone (DHT) levels, increased |
Tissue |
Nov 2, 2024 |
Nov 2, 2024 |
|
944 |
dimerization, AHR/ARNT |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
- Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
- Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
- AhR activation leading to preeclampsia
- Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
- Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
|
1869 |
Diminished protective oxidative stress response |
Cellular |
Apr 20, 2021 |
Oct 30, 2023 |
- Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
- SARS-CoV-2 infection leading to hyperinflammation
- SARS-CoV-2 infection leading to pyroptosis
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Increased reactive oxygen species production leading to decreased cognitive function
|
652 |
Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
|
1958 |
Direct hERG channel blockage |
Cellular |
Dec 13, 2021 |
Dec 13, 2021 |
|
1260 |
Direct mitochondrial inhibition |
Molecular |
Feb 7, 2017 |
Sep 16, 2017 |
- AOP from chemical insult to cell death
|
721 |
Disorganization, Meiotic Spindle |
Cellular |
Nov 29, 2016 |
Apr 20, 2021 |
- Chemical binding to tubulin in oocytes leading to aneuploid offspring
|
1830 |
Displacement, Serum thyroxine (T4) from carrier protein |
Molecular |
Dec 9, 2020 |
Dec 9, 2020 |
- Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
- Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
|
958 |
Displacement, Serum thyroxine (T4) from transthyretin |
Molecular |
Nov 29, 2016 |
Dec 17, 2016 |
- Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
|
2110 |
Disrupted binding, laminin-beta1-integrin receptors with laminin |
Molecular |
Feb 21, 2023 |
Feb 21, 2023 |
- Binding to the extracellular protein laminin leading to decreased cognitive function
|
2225 |
Disrupted Lipid Storage |
Cellular |
May 8, 2024 |
May 23, 2024 |
- Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
|
1882 |
Disrupted meiotic initiation of fetal oogonia of the ovary |
Cellular |
May 24, 2021 |
Feb 27, 2022 |
- Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary
|
2227 |
Disrupted PPAR isoform nuclear signaling |
Molecular |
May 14, 2024 |
May 22, 2024 |
- Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
|
1977 |
Disruption of sodium channel gating kinetics |
Cellular |
Mar 15, 2022 |
Jul 24, 2024 |
- Binding to voltage gate sodium channels during development leads to cognitive impairment
- Inhibition of voltage-gated sodium channels leading to decreased cognition
|
1983 |
Disruption, action potential generation |
Cellular |
Mar 31, 2022 |
Jul 24, 2024 |
- Binding to voltage gate sodium channels during development leads to cognitive impairment
|
2141 |
Disruption, Estrogen receptor |
Molecular |
May 17, 2023 |
May 17, 2023 |
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
|
1536 |
Disruption, Intracellular calcium mobilization |
Cellular |
Jun 21, 2018 |
Jun 21, 2018 |
- L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
|
898 |
Disruption, Lysosome |
Cellular |
Nov 29, 2016 |
Aug 29, 2024 |
- Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
- Endocytic lysosomal uptake leading to liver fibrosis
- Endocytotic lysosomal uptake leads to intestinal barrier disruption
|
169 |
Disruption, Membrane integrity |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Narcosis leading to respiratory failure
|
720 |
Disruption, Microtubule dynamics |
Molecular |
Nov 29, 2016 |
Nov 7, 2019 |
- Chemical binding to tubulin in oocytes leading to aneuploid offspring
|
178 |
Disruption, Mitochondrial electron transport chain |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Calcium-mediated neuronal ROS production and energy imbalance
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
|
1681 |
Disruption, Neural crest cell migration |
Cellular |
Aug 13, 2019 |
Aug 13, 2019 |
- TBX1 inhibition leading to congenital cardiac conotruncal anomalies
|
2151 |
Disruption, neurotransmitter release |
Molecular |
Jun 27, 2023 |
Jul 21, 2023 |
- Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release
- Various neuronal effects induced by elavl3, sox10, and mbp
- Binding and activation of GPER leading to learning and memory impairments
|
1682 |
Disruption, Progenitor cells of second heart field |
Cellular |
Aug 13, 2019 |
Feb 15, 2022 |
- TBX1 inhibition leading to congenital cardiac conotruncal anomalies
- Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
|
1537 |
Disruption, Sarcomere assembly |
Cellular |
Jun 21, 2018 |
Jun 21, 2018 |
- L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
|
1590 |
Distribution and deposition of chemicals to skin and/or eyes |
Molecular |
Feb 3, 2019 |
Feb 3, 2019 |
|
1581 |
Disturbance in microtubule dynamic instability |
Cellular |
Jan 29, 2019 |
Jan 29, 2019 |
- Microtubule interacting drugs lead to peripheral neuropathy
|
831 |
Disturbance, Lysosomal function |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
- Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
|
2114 |
Disturbed, cortical architecture |
Organ |
Feb 21, 2023 |
Feb 21, 2023 |
- Binding to the extracellular protein laminin leading to decreased cognitive function
|
2112 |
Disturbed, radial glia cell alignment and migration |
Cellular |
Feb 21, 2023 |
Feb 21, 2023 |
- Binding to the extracellular protein laminin leading to decreased cognitive function
|
1388 |
Dopamine release in the brain, decreased |
Tissue |
May 2, 2017 |
May 17, 2017 |
- Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
- Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
|
472 |
Down Regulation, CPT1A |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
- G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
|
1286 |
Down Regulation, GSS and GSTs gene |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
|
131 |
Down Regulation, Gulcose-6-phosphate dehydrogenase |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Oxidation of iron in hemoglobin leading to hematotoxicity
|
474 |
Down Regulation, HMGCS2 |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
|
427 |
Down Regulation, K-Cl co-transporter 2 (KCC2) |
Cellular |
Nov 29, 2016 |
Nov 29, 2016 |
|
1787 |
Downregulation, ACE2 |
Cellular |
May 15, 2020 |
Mar 31, 2021 |
- Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
- Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
- ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
|
2088 |
Dysfunction of respiratory system |
Individual |
Jan 9, 2023 |
Jan 9, 2023 |
- AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
|
1184 |
Dysfunction, Mitochondrial Dynamics |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1945 |
Dysfunctional Autophagy |
Cellular |
Oct 26, 2021 |
Oct 26, 2021 |
- A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
- Adverse outcome pathway of PM-induced respiratory toxicity
|
1850 |
dysgeusia |
Organ |
Mar 28, 2021 |
Apr 26, 2021 |
- Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
|
1703 |
Dysregulation of heart rate and vascular tone |
Organ |
Nov 25, 2019 |
Dec 20, 2019 |
- Acetylcholinesterase inhibition leading to acute mortality
|
2224 |
Dysregulation of transcriptional expression within PPAR signaling network |
Molecular |
May 8, 2024 |
May 23, 2024 |
- Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
|
1854 |
Dysregulation, ACE2 expression and activity |
Molecular |
Mar 31, 2021 |
Feb 18, 2023 |
- Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
- Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis
- Binding to ACE2 leading to lung fibrosis
|
1600 |
Eczematous eruption (Erythema, Papules, Vesicles, Pruritius, Weeping, Oozing, Crusting) |
Organ |
Feb 3, 2019 |
Feb 3, 2019 |
|
1248 |
EGFR , Activation |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1247 |
EGFR , PPAR-alpha activation |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
222 |
Elimination of (high doses), Posterior cardinal vein |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
2011 |
Emphysema |
Organ |
May 31, 2022 |
May 31, 2022 |
- Adverse outcome pathway of PM-induced respiratory toxicity
|
1841 |
Encephalitis |
Organ |
Feb 23, 2021 |
Feb 23, 2021 |
- Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1539 |
Endocytotic lysosomal uptake |
Molecular |
Nov 6, 2018 |
Aug 29, 2024 |
- Endocytic lysosomal uptake leading to liver fibrosis
- Endocytotic lysosomal uptake leads to intestinal barrier disruption
|
2017 |
Endoplasmic reticulum stress |
Cellular |
Jun 27, 2022 |
Jun 27, 2022 |
- PM2.5-related AOP frameworks on liver diseases
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
|
2175 |
Endothelial cell death |
Cellular |
Aug 21, 2023 |
Aug 21, 2023 |
|
1913 |
Endothelial cell dysfunction |
Cellular |
Aug 4, 2021 |
Aug 4, 2021 |
- Endothelial cell dysfunction leading to thromboinflammation
- SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
|
2212 |
Epididymal agenesis |
Organ |
Mar 19, 2024 |
Jun 28, 2024 |
- Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
|
2152 |
Epigenetic modification process |
Cellular |
Jul 27, 2023 |
Jul 27, 2023 |
- Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
|
1457 |
Epithelial Mesenchymal Transition |
Cellular |
Jul 26, 2017 |
Apr 24, 2024 |
- Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
- Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
- α-diketone-induced bronchiolitis obliterans
- Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
- Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway
- Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway
- DNA damage and mutations leading to Metastatic Breast Cancer
- Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
- Adverse outcome pathway of PM-induced respiratory toxicity
- Succinate dehydrogenase inactivation leads to cancer by promoting EMT
|
2251 |
Estradiol availability, increased |
Tissue |
Aug 9, 2024 |
Aug 12, 2024 |
|
1180 |
Estrogen receptor activation, |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
2126 |
Estrogen receptor alpha inactivation |
Molecular |
Apr 5, 2023 |
Apr 10, 2023 |
- ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
- ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
|
1714 |
Exacerbation of systemic lupus erythematosus (SLE) |
Individual |
Dec 29, 2019 |
Aug 14, 2020 |
- Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
|
1859 |
Excitation of intracellular water |
Molecular |
Apr 11, 2021 |
Apr 11, 2021 |
|
1217 |
Excitation of trigeminal nerves induces Sensory Airway Irritation, |
Organ |
Nov 29, 2016 |
Sep 24, 2018 |
|
1273 |
Expression of Collagen |
Cellular |
Feb 15, 2017 |
Feb 15, 2017 |
|
2153 |
Expression of factors ruling proliferation, modified |
Cellular |
Jul 27, 2023 |
Jul 27, 2023 |
- Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
|
1905 |
eya1 expression, inhibited |
Molecular |
Jul 14, 2021 |
Oct 7, 2021 |
- GSK3beta inactivation leading to increased mortality via defects in developing inner ear
|
1559 |
Facial cartilage structures are reduced in size and morphologically distorted |
Tissue |
Dec 20, 2018 |
Dec 20, 2018 |
- Histone deacetylase inhibition leads to impeded craniofacial development
- Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
|
1131 |
Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin) |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
|
1119 |
Failure in gamma-glutamyl carboxylation of glutamine residues on clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin) |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1130 |
Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
|
1528 |
Fatty Acid Beta Oxidation, Decreased |
Molecular |
Jun 11, 2018 |
Apr 30, 2019 |
- Antagonist binding to PPARα leading to body-weight loss
|
240 |
Feminisation or incomplete development, Primary and accessory male sex organs |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
|
2241 |
Ferroptosis related pathways activation |
Cellular |
Jul 9, 2024 |
Jul 9, 2024 |
- Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
|
1866 |
Fibrinolysis, decreased |
Molecular |
Apr 20, 2021 |
Oct 19, 2021 |
- Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
|
2012 |
Fibroblast proliferation and differentiation |
Cellular |
May 31, 2022 |
May 31, 2022 |
- Adverse outcome pathway of PM-induced respiratory toxicity
|
1587 |
Fibroproliferative airway lesions |
Tissue |
Jan 30, 2019 |
Jan 30, 2019 |
- α-diketone-induced bronchiolitis obliterans
|
1442 |
Foam cell formation |
Organ |
Jun 29, 2017 |
Jun 29, 2017 |
- Activation of reactive oxygen species leading the atherosclerosis
|
1597 |
Formation of DNA photo-adducts |
Cellular |
Feb 3, 2019 |
Feb 3, 2019 |
|
1440 |
Formation of HDL-SAA |
Cellular |
Jun 29, 2017 |
Jun 29, 2017 |
|
1899 |
formation of neutrophil extracellular traps (NETs) |
Cellular |
Jul 8, 2021 |
Jul 8, 2021 |
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
|
1598 |
Formation of protein photo-adducts |
Cellular |
Feb 3, 2019 |
Feb 3, 2019 |
|
118 |
Formation, Formation of hemoglobin adducts |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Oxidation of iron in hemoglobin leading to hematotoxicity
|
856 |
Formation, Hepatocellular and Bile duct tumors |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Sustained AhR Activation leading to Rodent Liver Tumours
|
840 |
Formation, Liver fibrosis |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
|
347 |
Formation, Liver tumor |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
|
839 |
Formation, Mallory body |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
|
373 |
Formation, Pro-mutagenic DNA Adducts |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
|
976 |
Formation, The binding of FK506 with FKBP12 |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
|
1903 |
foxi1 expression, increased |
Molecular |
Jul 14, 2021 |
Oct 28, 2021 |
- GSK3beta inactivation leading to increased mortality via defects in developing inner ear
|
1911 |
FOXJ1 Protein, Decreased |
Cellular |
Jul 23, 2021 |
Sep 10, 2021 |
- Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
|
1646 |
Frizzled activation |
Molecular |
May 29, 2019 |
May 29, 2019 |
|
1668 |
Frustrated phagocytosis |
Cellular |
Jul 3, 2019 |
Sep 16, 2022 |
- Frustrated phagocytosis-induced lung cancer
- Frustrated phagocytosis leads to malignant mesothelioma
|
1932 |
Gastrointestinal disorders |
Individual |
Sep 2, 2021 |
Sep 8, 2021 |
|
1513 |
General Apoptosis |
Cellular |
Apr 4, 2018 |
Oct 18, 2023 |
- CYP2E1 activation and formation of protein adducts leading to neurodegeneration
- Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
- Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
|
1236 |
Generation of novel epitopes , Antigen presentation |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
|
682 |
Generation, Amplified excitatory postsynaptic potential (EPSP) |
Cellular |
Nov 29, 2016 |
May 18, 2018 |
- Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
|
1896 |
Genomic instability |
Cellular |
Jul 6, 2021 |
Jul 6, 2021 |
- Frustrated phagocytosis leads to malignant mesothelioma
- Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
|
1953 |
Gestational diabetes mellitus |
Individual |
Nov 18, 2021 |
Nov 18, 2021 |
- Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
|
494 |
Glucocorticoid Receptor Agonist, Activation |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
|
651 |
Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
|
1488 |
Glutamate dyshomeostasis |
Cellular |
Nov 9, 2017 |
Jul 15, 2022 |
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
|
1290 |
Glutathione homeostasis |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
|
1287 |
Glutathione synthesis |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
|
2254 |
Gluten-reactive and transglutaminase 2 reactive B cell receptors, generation |
Molecular |
Aug 13, 2024 |
Sep 13, 2024 |
- Gluten intake leading to celiac disease - under development
|
2256 |
Gluten-reactive B cells and transglutaminase 2-reactive B cells, activation and differentiation |
Cellular |
Aug 13, 2024 |
Sep 13, 2024 |
- Gluten intake leading to celiac disease - under development
|
2260 |
Gluten-reactive CD4+ T cells, activation and proliferation |
Cellular |
Sep 13, 2024 |
Sep 13, 2024 |
- Gluten intake leading to celiac disease - under development
|
2253 |
Gluten-reactive T cell receptors, generation |
Molecular |
Aug 13, 2024 |
Sep 13, 2024 |
- Gluten intake leading to celiac disease - under development
|
1519 |
Glycolysis |
Cellular |
May 24, 2018 |
May 24, 2018 |
|
1800 |
Granulosa cell proliferation of gonadotropin-independent follicles, Reduced |
Cellular |
Oct 13, 2020 |
Apr 20, 2022 |
- Androgen receptor (AR) antagonism leading to decreased fertility in females
|
1467 |
Growth, reduction |
Individual |
Aug 3, 2017 |
Aug 3, 2017 |
- Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
|
1647 |
GSK3beta inactivation |
Molecular |
May 29, 2019 |
Oct 5, 2021 |
- GSK3beta inactivation leading to increased mortality via defects in developing inner ear
|
1954 |
Gut microbiota, alteration |
Organ |
Nov 30, 2021 |
Jan 4, 2022 |
- Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis
|
1535 |
Heart failure |
Organ |
Jun 19, 2018 |
Sep 27, 2024 |
- L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
- ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
- Decreased Sodium/Potassium ATPase activity leads to Heart failure
|
1412 |
Helicobacter pylori infection |
Tissue |
Jun 2, 2017 |
Jun 2, 2017 |
- Helicobacter pylori to gastric ulcer
|
1124 |
Hemorrhage , Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1121 |
Hemorrhage , organ dysfunction, hypovolemic shock |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1123 |
Hemorrhage, organ dysfunction, hypovolemic shock, Impaired oxygen delivery to tissue |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1133 |
Hemostasis, Depletion from blood of fully functional carboxylated clotting factors |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
|
2016 |
Hepatocyte cell apoptosis |
Cellular |
Jun 7, 2022 |
Jun 7, 2022 |
|
1393 |
Hepatocytotoxicity |
Cellular |
May 30, 2017 |
Jun 19, 2021 |
- Cyp2E1 Activation Leading to Liver Cancer
|
1291 |
Hepatotoxicity |
Cellular |
Feb 15, 2017 |
Feb 15, 2017 |
- Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
|
1957 |
hERG channel biogenesis interference |
Molecular |
Dec 13, 2021 |
Dec 13, 2021 |
|
2099 |
hERG channel blockade |
Molecular |
Jan 29, 2023 |
Jan 29, 2023 |
- hERG channel blockade leading to sudden cardiac death
|
757 |
Hippocampal anatomy, Altered |
Tissue |
Nov 29, 2016 |
Jul 24, 2024 |
- Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
- Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Binding to voltage gate sodium channels during development leads to cognitive impairment
|
756 |
Hippocampal gene expression, Altered |
Tissue |
Nov 29, 2016 |
Aug 11, 2018 |
- Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
- Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
|
758 |
Hippocampal Physiology, Altered |
Tissue |
Nov 29, 2016 |
Jul 24, 2024 |
- Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
- Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
- AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Binding to voltage gate sodium channels during development leads to cognitive impairment
|
1503 |
Histone acetylation, increase |
Cellular |
Jan 21, 2018 |
Jul 28, 2021 |
- Histone deacetylase inhibition leading to testicular atrophy
- Histone deacetylase inhibition leads to neural tube defects
|
1502 |
Histone deacetylase inhibition |
Molecular |
Jan 21, 2018 |
Jul 14, 2022 |
- Histone deacetylase inhibition leading to testicular atrophy
- Histone deacetylase inhibition leads to impeded craniofacial development
- Histone deacetylase inhibition leads to neural tube defects
- Ceramide synthase inhibition leading to neural tube defects
|
2252 |
Human leukocyte antigen DQ2/8-gluten complexes, formation |
Molecular |
Aug 13, 2024 |
Sep 13, 2024 |
- Gluten intake leading to celiac disease - under development
|
1853 |
Hyperactivation of ACE/Ang-II/AT1R axis |
Molecular |
Mar 31, 2021 |
Mar 31, 2021 |
- Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
- ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
|
1868 |
Hyperinflammation |
Tissue |
Apr 20, 2021 |
Dec 29, 2021 |
- Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
- SARS-CoV-2 infection leading to hyperinflammation
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
|
1943 |
Hyperphosphorylation of Tau |
Cellular |
Oct 26, 2021 |
Oct 26, 2021 |
- A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
|
142 |
Hyperplasia, Hyperplasia |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Uncharacterized liver damage leading to hepatocellular carcinoma
|
415 |
Hyperplasia, Leydig cell |
Cellular |
Nov 29, 2016 |
Sep 27, 2017 |
- PPARα activation leading to impaired fertility in adult male rodents
|
1078 |
Hyperplasia, Mammary gland |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
|
1052 |
Hyperplasia, ovarian epithelium |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
- Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
|
1051 |
Hyperplasia, ovarian stromal cells |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
|
763 |
hyperpolarisation, neuron |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Glutamate-gated chloride channel activation leading to acute mortality
- Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
- Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
|
943 |
Hypersecretion, Mucus |
Organ |
Nov 29, 2016 |
Nov 29, 2016 |
|
952 |
Hypertension |
Individual |
Nov 29, 2016 |
Sep 27, 2017 |
- Peptide Oxidation Leading to Hypertension
- Na+ /K+ -ATPase inhibition leading to hypertension
|
1043 |
Hypertrophy/hyperplasia, smooth muscle |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
|
1095 |
hyperuricemia, |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
2107 |
Hypomyelination |
Tissue |
Feb 21, 2023 |
Feb 21, 2023 |
- Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
- Unknown MIE altering cholesterol metabolism leading to decreased cognition
- Increased reactive oxygen species production leading to decreased cognitive function
- Inhibition of voltage-gated sodium channels leading to decreased cognition
- Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|
2082 |
Hypospadias, increased |
Organ |
Dec 18, 2022 |
Jul 16, 2024 |
- Androgen receptor (AR) antagonism leading to hypospadias in male offspring
- Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
|
1819 |
IFNγ signaling |
Cellular |
Nov 2, 2020 |
Nov 2, 2020 |
- Immune mediated hepatitis
|
1856 |
Imbalanced salty and sweet taste responses |
Tissue |
Apr 7, 2021 |
Apr 7, 2021 |
- Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
|
1818 |
Immune cell activation |
Cellular |
Nov 2, 2020 |
Nov 2, 2020 |
- Immune mediated hepatitis
|
2180 |
Immune mechanisms antagonized by viral proteins |
Molecular |
Aug 23, 2023 |
Dec 13, 2023 |
- Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
|
1820 |
Immune mediated hepatitis |
Organ |
Nov 2, 2020 |
Nov 2, 2020 |
- Immune mediated hepatitis
|
1225 |
Immune system inflammation |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
|
1644 |
Impaired Ab production |
Cellular |
May 23, 2019 |
Jun 25, 2019 |
|
1568 |
Impaired antigen presentation |
Organ |
Dec 24, 2018 |
Dec 24, 2018 |
|
1582 |
Impaired axonial transport |
Cellular |
Jan 29, 2019 |
Jan 29, 2019 |
- Microtubule interacting drugs lead to peripheral neuropathy
- A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1705 |
Impaired coordination and movement |
Individual |
Dec 20, 2019 |
Dec 20, 2019 |
- Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
|
364 |
Impaired development of, Reproductive organs |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Estrogen receptor agonism leading to reproductive dysfunction
- Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
|
1849 |
Impaired gustatory nerve |
Tissue |
Mar 28, 2021 |
Apr 7, 2021 |
- Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
|
1572 |
Impaired IL-1 signaling |
Molecular |
Dec 24, 2018 |
Jun 24, 2019 |
|
1700 |
Impaired IL-1R1 signaling in T cell |
Molecular |
Nov 17, 2019 |
Mar 2, 2023 |
- Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
|
1615 |
Impaired inguinoscrotal testicular descent phase |
Organ |
Apr 10, 2019 |
Jul 18, 2024 |
- Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
- Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis
|
2144 |
Impaired insulin signaling |
Cellular |
May 25, 2023 |
May 25, 2023 |
- ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
|
1833 |
Impaired lung function |
Individual |
Jan 8, 2021 |
Feb 16, 2021 |
|
1946 |
Impaired mechanotransduction of pericytes |
Cellular |
Oct 28, 2021 |
Oct 28, 2021 |
- SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
|
1873 |
impaired olfactory function (anosmia) |
Organ |
Apr 25, 2021 |
Mar 30, 2022 |
- SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
|
1695 |
Impaired ovulation |
Organ |
Oct 3, 2019 |
Oct 3, 2019 |
- Luteinizing hormone receptor antagonism leading to reproductive dysfunction
|
1125 |
Impaired oxygen and nutrient delivery to tissue, impaired removal of carbon dioxide and other waste products, Hemorrhage, organ dysfunction and hypovolemic shock |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1678 |
Impaired oxygenation of the blood |
Organ |
Jul 3, 2019 |
Jul 3, 2019 |
|
2179 |
Impaired Platelet Aggregation |
Tissue |
Aug 21, 2023 |
Aug 21, 2023 |
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
|
1136 |
Impaired recruitment , Population trajectory |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
|
1569 |
Impaired T cell activation |
Cellular |
Dec 24, 2018 |
Jun 25, 2019 |
|
2080 |
Impaired, blood testis barrier |
Organ |
Dec 13, 2022 |
Dec 13, 2022 |
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
|
577 |
impaired, Development |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Suppression of immune system contributes to impaired development and leads to colony loss/failure
|
406 |
impaired, Fertility |
Individual |
Nov 29, 2016 |
Sep 14, 2023 |
- Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
- PPARα activation leading to impaired fertility in adult male rodents
- PPARα activation in utero leading to impaired fertility in males
- Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
- Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
- Inhibition of 11β-hydroxylase leading to decresed population trajectory
- Deposition of ionizing energy leads to population decline via impaired meiosis
- Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary
- Glutathione conjugation leading to reproductive dysfunction via oxidative stress
- Androgen receptor (AR) antagonism leading to decreased fertility in females
|
568 |
impaired, Hive thermoregulation |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
- Suppression of immune system contributes to impaired development and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
|
697 |
impaired, ion channels |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Altered ion channel activity leading impaired heart function
|
566 |
impaired, Larval development |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
- Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure
- Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
|
637 |
impaired, Learning and memory |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Various neuronal effects induced by elavl3, sox10, and mbp
|
2106 |
Impaired, oligodendrocyte maturation |
Cellular |
Feb 21, 2023 |
Feb 21, 2023 |
- Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
|
1989 |
Impaired, Oocyte maturation and ovulation |
Tissue |
Apr 5, 2022 |
Apr 5, 2022 |
- Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
|
889 |
Impaired, Proteostasis |
Cellular |
Nov 29, 2016 |
Mar 15, 2018 |
- Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
- Mitochondrial complex inhibition leading to liver injury
|
1991 |
Impaired, Reproduction |
Population |
Apr 5, 2022 |
Apr 5, 2022 |
- Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
|
1758 |
Impaired, Spermatogenesis |
Organ |
Apr 16, 2020 |
Apr 10, 2024 |
- PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
- Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
- Essential element imbalance leads to reproductive failure via oxidative stress
- Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
|
583 |
impaired, Thoracic shivering |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
|
2213 |
Impaired, urethral tube closure |
Organ |
Mar 19, 2024 |
Jun 28, 2024 |
- Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
|
1667 |
Impaired,anterior-posterior axis development |
Individual |
Jul 3, 2019 |
Jul 3, 2019 |
- Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
|
1719 |
Impairment of T-cell dependent antibody response |
Individual |
Jan 5, 2020 |
Feb 24, 2021 |
- Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
|
986 |
Impairment of TDAR |
Individual |
Nov 29, 2016 |
Mar 2, 2023 |
|
110 |
Impairment, Endothelial network |
Cellular |
Nov 29, 2016 |
Jan 18, 2022 |
- Disruption of VEGFR Signaling Leading to Developmental Defects
- Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
|
1683 |
Impairment, Fourth pharyngeal arch development |
Tissue |
Aug 13, 2019 |
Aug 13, 2019 |
- TBX1 inhibition leading to congenital cardiac conotruncal anomalies
|
341 |
Impairment, Learning and memory |
Individual |
Nov 29, 2016 |
Jul 26, 2024 |
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
- Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
- Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
- Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
- Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
- Histamine (H2) receptor antagonism leading to reduced survival
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
- Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
- Deposition of Energy Leading to Learning and Memory Impairment
- Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
- Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release
- Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
- Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory
- Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
- Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory
- Binding and activation of GPER leading to learning and memory impairments
|
984 |
Impairment, T-cell dependent antibody response |
Individual |
Nov 29, 2016 |
Feb 19, 2023 |
- Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
- Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
|
1328 |
Inactivated, 5-HTR (serotonin receptors) |
Molecular |
Apr 13, 2017 |
May 31, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Mental stress to depression
- Mental stress to agitation
- Serotonin transporter activation to agitation
- Serotonin transporter activation to depression
|
1270 |
Inactivation of PPARγ |
Molecular |
Feb 15, 2017 |
Dec 26, 2017 |
- Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
- Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
|
1356 |
Inactive, membrane depolarization |
Molecular |
Apr 14, 2017 |
Apr 14, 2017 |
- Molecular events lead to epilepsy
|
155 |
Inadequate DNA repair |
Cellular |
Nov 29, 2016 |
Mar 8, 2024 |
- Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
- Alkylation of DNA leading to cancer 2
- Alkylation of DNA leading to cancer 1
- Oxidative DNA damage leading to chromosomal aberrations and mutations
- Deposition of energy leading to lung cancer
- Alkylation of DNA leading to reduced sperm count
- Bulky DNA adducts leading to mutations
- Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
- DNA damage and mutations leading to Metastatic Breast Cancer
- Deposition of energy leading to occurrence of cataracts
|
1552 |
Inadequate DNA repair (deprecated, please use https://aopwiki.org/events/155) |
Molecular |
Dec 19, 2018 |
Jan 25, 2019 |
|
1555 |
Increase cell proliferation |
Cellular |
Dec 19, 2018 |
Dec 19, 2018 |
- AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation
|
1554 |
Increase Chromosomal Aberrations |
Molecular |
Dec 19, 2018 |
Aug 27, 2023 |
- DNA damage and mutations leading to Metastatic Breast Cancer
|
1633 |
Increase in inflammation |
Tissue |
May 3, 2019 |
May 3, 2019 |
- Immune mediated hepatitis
- Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
- ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
|
1632 |
Increase in reactive oxygen and nitrogen species (RONS) |
Molecular |
May 3, 2019 |
May 8, 2019 |
- Increased DNA damage leading to increased risk of breast cancer
- Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
- Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
- Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
- Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
|
1553 |
Increase mutations |
Molecular |
Dec 19, 2018 |
Dec 19, 2018 |
- Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress
|
1713 |
Increase of anti-DNA antibody from autoreactive B cell |
Cellular |
Dec 29, 2019 |
Aug 14, 2020 |
- Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
|
1712 |
Increase of Th2 cells producing IL-4 |
Cellular |
Dec 29, 2019 |
Aug 14, 2020 |
- Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
|
2073 |
increase oxidation of the di-copper moiety of the hemocyanin active site |
Molecular |
Nov 16, 2022 |
Nov 16, 2022 |
- Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
|
1743 |
Increase plasma Ang II |
Tissue |
Mar 10, 2020 |
Mar 10, 2020 |
- Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
|
416 |
Increase proliferation, Leydig cell |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARα activation leading to impaired fertility in adult male rodents
|
1978 |
Increase risk, microcephaly |
Individual |
Mar 17, 2022 |
Mar 18, 2022 |
- Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
- Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
|
2056 |
Increase, delay in oviposition |
Individual |
Aug 28, 2022 |
Aug 28, 2022 |
- Doda decarboxylase leading to mortality
|
2054 |
Increase, impairment of cuticle sclerotization |
Individual |
Aug 28, 2022 |
Aug 28, 2022 |
- Doda decarboxylase leading to mortality
|
2055 |
Increase, pigmentation |
Individual |
Aug 28, 2022 |
Aug 28, 2022 |
- Doda decarboxylase leading to mortality
|
2098 |
Increase, Abnormal Neural Remodeling |
Tissue |
Jan 25, 2023 |
Jul 26, 2024 |
- Deposition of Energy Leading to Learning and Memory Impairment
|
1768 |
Increase, Abnormal osmoregulation |
Tissue |
Apr 30, 2020 |
Aug 6, 2024 |
- Excessive reactive oxygen species production leading to mortality (1)
|
736 |
Increase, Adenomas/carcinomas (bronchioloalveolar) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
|
741 |
Increase, Adenomas/carcinomas (follicular cell) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
- Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
- Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
|
713 |
Increase, Adenomas/carcinomas (renal tubular) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
- Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
|
797 |
Increase, Adenomas/carcinomas (urothelial) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
|
2045 |
Increase, Alcohol dehydrogenase |
Molecular |
Aug 28, 2022 |
Aug 28, 2022 |
- Alcohol dehydrogenase leading to reproductive dysfunction
|
313 |
Increase, Allergic Respiratory Hypersensitivity Response |
Organ |
Nov 29, 2016 |
Feb 7, 2023 |
- Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
|
1384 |
Increase, ammonium (NH4+) |
Molecular |
Apr 17, 2017 |
Apr 17, 2017 |
- Gastric ulcer formation
- Helicobacter pylori to gastric ulcer
|
2134 |
Increase, Androgen receptor |
Molecular |
May 11, 2023 |
May 11, 2023 |
- Androgen receptor activation leading to prostate cancer
|
728 |
Increase, Aneuploid offspring |
Individual |
Nov 29, 2016 |
May 27, 2019 |
- Chemical binding to tubulin in oocytes leading to aneuploid offspring
|
1376 |
Increase, angiogenesis |
Tissue |
Apr 17, 2017 |
Feb 29, 2024 |
- Gastric ulcer formation
- Activation of the AhR leading to metastatic breast cancer
|
1365 |
Increase, Apoptosis |
Cellular |
Apr 15, 2017 |
Apr 15, 2017 |
- Alkylation of DNA leading to reduced sperm count
- Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
- Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
- Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
- Excessive reactive oxygen species production leading to mortality (4)
|
1372 |
Increase, bicarbonate |
Molecular |
Apr 17, 2017 |
Apr 17, 2017 |
|
401 |
Increase, Biliary excretion TH glucuronide |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
|
1769 |
Increase, Body fluid overload |
Tissue |
Apr 30, 2020 |
Apr 30, 2020 |
- Excessive reactive oxygen species production leading to mortality (1)
|
2048 |
Increase, Body volume of female adults |
Individual |
Aug 28, 2022 |
Aug 28, 2022 |
- Alcohol dehydrogenase leading to reproductive dysfunction
|
2090 |
Increase, Bone Remodeling |
Tissue |
Jan 11, 2023 |
Aug 13, 2024 |
- Deposition of energy leading to occurrence of bone loss
|
50 |
Increase, Ca++ (intracellular) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Calcium-mediated neuronal ROS production and energy imbalance
|
885 |
Increase, Cancer |
Tissue |
Nov 29, 2016 |
Aug 22, 2023 |
- Alkylation of DNA leading to cancer 2
- Alkylation of DNA leading to cancer 1
- Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
- Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
- Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress
- Succinate dehydrogenase inactivation leads to cancer by promoting EMT
- Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
|
2084 |
Increase, Cardiac remodelling |
Tissue |
Jan 5, 2023 |
Jan 5, 2023 |
- Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
|
1774 |
Increase, Caspase transcription |
Molecular |
Apr 30, 2020 |
Apr 30, 2020 |
- DNA methyltransferase inhibition leading to population decline (1)
- DNA methyltransferase inhibition leading to population decline (2)
- DNA methyltransferase inhibition leading to population decline (3)
- DNA methyltransferase inhibition leading to population decline (4)
|
1779 |
Increase, Caspase transcription (F3) |
Molecular |
Apr 30, 2020 |
Apr 30, 2020 |
- DNA methyltransferase inhibition leading to transgenerational effects (1)
- DNA methyltransferase inhibition leading to transgenerational effects (2)
|
1825 |
Increase, Cell death |
Cellular |
Dec 4, 2020 |
Aug 23, 2024 |
- Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
- Mitochondrial complex III antagonism leading to growth inhibition (2)
- Cytochrome oxidase inhibition leading to olfactory nasal lesions
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- GSK3beta inactivation leading to increased mortality via defects in developing inner ear
- Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
- Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
- Deposition of energy leading to occurrence of bone loss
|
55 |
Increase, Cell injury/death |
Cellular |
Nov 29, 2016 |
May 27, 2024 |
- Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
- Protein Alkylation leading to Liver Fibrosis
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
- Endocytic lysosomal uptake leading to liver fibrosis
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
- IKK complex inhibition leading to liver injury
- Acetylcholinesterase Inhibition Leading to Neurodegeneration
- Mitochondrial complex inhibition leading to liver injury
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
- Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death
- Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
- Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
- Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
- Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
- AhR activation leading to liver fibrosis
- Endocytotic lysosomal uptake leads to intestinal barrier disruption
- Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death
- Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death
- Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell death
|
1527 |
Increase, Cell membrane depolarization |
Cellular |
May 24, 2018 |
May 24, 2018 |
- S-adenosylmethionine depletion leading to population decline (2)
- Sulfonylureareceptor binding leading to mortality
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
- Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
|
870 |
Increase, Cell Proliferation |
Cellular |
Nov 29, 2016 |
Mar 8, 2024 |
- Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
- Frustrated phagocytosis-induced lung cancer
- Deposition of energy leading to lung cancer
- Frustrated phagocytosis leads to malignant mesothelioma
- Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway
- Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
- Interaction with lung resident cell membrane components leads to lung cancer
- Deposition of energy leading to occurrence of cataracts
|
1182 |
Increase, Cell Proliferation (Epithelial Cells) |
Cellular |
Nov 29, 2016 |
May 8, 2019 |
- Estrogen receptor activation leading to breast cancer
- Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
- Increased DNA damage leading to increased risk of breast cancer
|
716 |
Increase, cell proliferation (hepatocytes) |
Cellular |
Nov 29, 2016 |
Jan 6, 2021 |
- Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
- Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
- PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
|
1636 |
Increase, Chromosomal aberrations |
Cellular |
May 19, 2019 |
Mar 8, 2024 |
- Oxidative DNA damage leading to chromosomal aberrations and mutations
- Deposition of energy leading to lung cancer
- Deposition of energy leading to occurrence of cataracts
|
621 |
Increase, cilia movement |
Tissue |
Nov 29, 2016 |
Jan 13, 2017 |
- 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
- 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
- 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
|
1171 |
Increase, Clonal Expansion of Altered Hepatic Foci |
Cellular |
Nov 29, 2016 |
Jan 6, 2021 |
- PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
|
2195 |
Increase, CNS Neural cell death |
Cellular |
Oct 17, 2023 |
Oct 17, 2023 |
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1334 |
Increase, cortisone |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
|
1269 |
Increase, COX-2 expression |
Molecular |
Feb 9, 2017 |
Mar 20, 2018 |
- Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
|
1759 |
Increase, Cripto-1 expression |
Cellular |
Apr 20, 2020 |
Jul 10, 2020 |
- Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
|
320 |
Increase, Curved body axis |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1812 |
Increase, Cytochrome c release |
Cellular |
Nov 2, 2020 |
Nov 2, 2020 |
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
|
2064 |
Increase, Cytosolic calcium |
Cellular |
Sep 13, 2022 |
Sep 13, 2022 |
- Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
|
1305 |
Increase, cytosolic fatty acid |
Cellular |
Apr 12, 2017 |
Nov 27, 2017 |
- Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
|
768 |
Increase, Cytotoxicity |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
- Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
|
770 |
Increase, Cytotoxicity (club cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
|
776 |
Increase, Cytotoxicity (corneal cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
|
780 |
Increase, Cytotoxicity (epithelial cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
- Interaction with lung resident cell membrane components leads to lung cancer
|
786 |
Increase, Cytotoxicity (hepatocytes) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
|
709 |
Increase, Cytotoxicity (renal tubular cell) |
Cellular |
Nov 29, 2016 |
Mar 3, 2022 |
- Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
- Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
- Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
- Renal protein alkylation leading to kidney toxicity
- Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
|
783 |
Increase, Cytotoxicity (tubular epithelial cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
|
794 |
Increase, Cytotoxicity (urothelial cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
|
1516 |
Increase, D1 protein antagonism |
Molecular |
May 24, 2018 |
Oct 7, 2020 |
|
1861 |
Increase, D1 protein deactivation |
Cellular |
Apr 11, 2021 |
Apr 11, 2021 |
- Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
|
2053 |
Increase, Defects in tanning of new cuticle |
Individual |
Aug 28, 2022 |
Aug 28, 2022 |
- Doda decarboxylase leading to mortality
|
2050 |
Increase, developmental abnormalities |
Individual |
Aug 28, 2022 |
Aug 28, 2022 |
- Alcohol dehydrogenase leading to reproductive dysfunction
- Knickkopf leading to mortality
|
1456 |
Increase, Differentiation of fibroblasts |
Cellular |
Jul 26, 2017 |
Jul 26, 2017 |
- Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
|
1194 |
Increase, DNA damage |
Molecular |
Nov 29, 2016 |
May 8, 2019 |
- Estrogen receptor activation leading to breast cancer
- Increased DNA damage leading to increased risk of breast cancer
- Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
- Deposition of ionizing energy leads to population decline via impaired meiosis
- Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
- Deposition of ionising energy leading to population decline via programmed cell death
- Deposition of ionising energy leads to population decline via pollen abnormal
- Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
- Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
- Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
|
1461 |
Increase, DNA double-strand breaks |
Molecular |
Aug 2, 2017 |
Nov 13, 2023 |
- Inhibitor binding to topoisomerase II leading to infant leukaemia
- DNA methyltransferase inhibition leading to population decline (4)
- DNA methyltransferase inhibition leading to population decline (3)
- Excessive reactive oxygen species production leading to mortality (4)
|
1620 |
Increase, DNA hypomethylation |
Molecular |
Apr 22, 2019 |
Apr 22, 2019 |
|
1697 |
Increase, DNA methyltransferase expression |
Molecular |
Oct 30, 2019 |
Oct 30, 2019 |
- Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
|
1619 |
Increase, DNA methyltransferase inhibition |
Molecular |
Apr 22, 2019 |
Apr 22, 2019 |
- DNA methyltransferase inhibition leading to population decline (1)
- DNA methyltransferase inhibition leading to population decline (2)
- DNA methyltransferase inhibition leading to population decline (3)
- DNA methyltransferase inhibition leading to population decline (4)
- DNA methyltransferase inhibition leading to transgenerational effects (1)
- DNA methyltransferase inhibition leading to transgenerational effects (2)
- Succinate dehydrogenase inactivation leads to cancer by promoting EMT
|
1635 |
Increase, DNA strand breaks |
Molecular |
May 19, 2019 |
Aug 26, 2024 |
- Oxidative DNA damage leading to chromosomal aberrations and mutations
- Deposition of energy leading to lung cancer
- Alkylation of DNA leading to reduced sperm count
- Deposition of energy leading to population decline via DNA strand breaks and follicular atresia
- Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis
- Deposition of energy leading to occurrence of cataracts
- Deposition of Energy Leading to Learning and Memory Impairment
- Deposition of energy leads to abnormal vascular remodeling
|
746 |
Increase, Dopaminergic activity |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
|
947 |
Increase, Early Life Stage Mortality |
Individual |
Nov 29, 2016 |
Mar 22, 2018 |
- Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
- Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
- Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
- Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
|
103 |
Increase, Ecdysone receptor agonism |
Molecular |
Nov 29, 2016 |
May 24, 2018 |
- Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
|
773 |
Increase, Endometrial adenocarcinomas |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
|
2068 |
Increase, Endothelial Dysfunction |
Tissue |
Sep 28, 2022 |
Aug 26, 2024 |
- Deposition of energy leads to abnormal vascular remodeling
- Activation of reactive oxygen species leading the atherosclerosis
|
573 |
Increase, Energetic demands and therefore metabolic stress |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
|
1860 |
Increase, Excitation of intracellular water |
Molecular |
Apr 11, 2021 |
Apr 11, 2021 |
|
115 |
Increase, FA Influx |
Cellular |
Nov 29, 2016 |
Mar 29, 2024 |
- LXR activation leading to hepatic steatosis
- Pregnane X Receptor (PXR) activation leads to liver steatosis
|
1312 |
Increase, Fatty acid beta-oxidation |
Cellular |
Apr 13, 2017 |
Dec 4, 2020 |
|
1994 |
Increase, Ferroptosis |
Cellular |
Apr 7, 2022 |
Apr 7, 2022 |
|
1444 |
Increase, Follicular atresia |
Organ |
Jun 29, 2017 |
Nov 25, 2020 |
- Deposition of energy leading to population decline via DNA strand breaks and follicular atresia
- Deposition of energy leading to population decline via DNA oxidation and follicular atresia
|
1765 |
Increase, Formation of DNA photoproducts |
Molecular |
Apr 30, 2020 |
Apr 30, 2020 |
|
1265 |
Increase, Fushi tarazu factor-1 gene expression |
Molecular |
Feb 9, 2017 |
May 24, 2018 |
- Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
|
1361 |
Increase, GABA |
Molecular |
Apr 14, 2017 |
Apr 14, 2017 |
- Molecular events lead to epilepsy
|
1621 |
Increase, Gene expression |
Molecular |
Apr 22, 2019 |
Apr 22, 2019 |
|
1175 |
Increase, Genes involved in fatty acid oxidation |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
|
1827 |
Increase, Global DNA methylation |
Molecular |
Dec 4, 2020 |
Dec 4, 2020 |
|
2133 |
Increase, Glucuronidation of T4 |
Molecular |
Apr 12, 2023 |
Apr 12, 2023 |
|
2070 |
Increase, Glycolysis |
Cellular |
Nov 1, 2022 |
Nov 1, 2022 |
- Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
|
2117 |
Increase, goblet cell number |
Cellular |
Mar 8, 2023 |
Mar 8, 2023 |
- EGFR Activation Leading to Decreased Lung Function
|
2137 |
Increase, Gonadotropins concentration in plasma |
Tissue |
May 16, 2023 |
May 16, 2023 |
- Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
|
1480 |
Increase, Growth hormone |
Organ |
Oct 10, 2017 |
Feb 16, 2021 |
|
2076 |
Increase, hemocyanin mRNA |
Tissue |
Nov 16, 2022 |
Nov 16, 2022 |
- Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
|
719 |
Increase, hepatocellular adenomas and carcinomas |
Tissue |
Nov 29, 2016 |
Dec 26, 2020 |
- Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
- Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
- Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
- Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
- PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
|
336 |
Increase, Heritable mutations in offspring |
Individual |
Nov 29, 2016 |
Nov 29, 2016 |
- Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
|
1698 |
Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor |
Molecular |
Oct 30, 2019 |
Oct 30, 2019 |
- Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
|
740 |
Increase, Hyperplasia (follicular cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
- Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
- Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
|
782 |
Increase, Hyperplasia (forestomach epithelial cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
|
772 |
Increase, Hyperplasia (glandular epithelial cells of endometrium) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
- Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
|
744 |
Increase, Hyperplasia (Leydig cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
- Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
|
767 |
Increase, Hyperplasia (renal tubular cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
|
735 |
Increase, Hyperplasia (terminal bronchiolar cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
|
784 |
Increase, Hyperplasia (tubular epithelial cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
|
796 |
Increase, Hyperplasia (urothelial) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
- AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
|
1343 |
Increase, hypertension |
Individual |
Apr 13, 2017 |
Apr 13, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
739 |
Increase, Hypertrophy and proliferation (follicular cell) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
- Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
- Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
|
1707 |
Increase, IL-23 from matured dendritic cells |
Cellular |
Dec 27, 2019 |
Nov 23, 2020 |
- Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
|
990 |
Increase, Incomplete ecdysis |
Individual |
Nov 29, 2016 |
May 24, 2018 |
- Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
- Doda decarboxylase leading to mortality
- Knickkopf leading to mortality
|
149 |
Increase, Inflammation |
Cellular |
Nov 29, 2016 |
Feb 28, 2024 |
- Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
- Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
- Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
- α-diketone-induced bronchiolitis obliterans
- Activation of the AhR leading to metastatic breast cancer
- Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
- Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
|
777 |
Increase, Inflammation (corneal cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
|
1338 |
Increase, inositol triphosphate |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
1296 |
Increase, insulin |
Molecular |
Apr 12, 2017 |
Apr 12, 2017 |
|
1339 |
Increase, intracellular calcium |
Cellular |
Apr 13, 2017 |
Jul 21, 2023 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- SSRI (Selective serotonin reuptake inhibitor) to hypertension
- Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release
- Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
|
1378 |
Increase, leukocyte adherence |
Tissue |
Apr 17, 2017 |
Apr 17, 2017 |
|
745 |
Increase, Leydig cell tumors |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
- Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
|
1445 |
Increase, Lipid peroxidation |
Molecular |
Jun 29, 2017 |
Oct 8, 2024 |
- Excessive reactive oxygen species production leading to mortality (3)
- Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
- Glutathione conjugation leading to reproductive dysfunction via oxidative stress
- Essential element imbalance leads to reproductive failure via oxidative stress
- Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death
- Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation
|
161 |
Increase, Liver and splenic hemosiderosis |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Oxidation of iron in hemoglobin leading to hematotoxicity
|
1556 |
Increase, lung cancer |
Organ |
Dec 19, 2018 |
Jan 10, 2023 |
- Deposition of energy leading to lung cancer
|
414 |
Increase, Luteinizing hormone (LH) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARα activation leading to impaired fertility in adult male rodents
|
1333 |
Increase, mental stress |
Individual |
Apr 13, 2017 |
Apr 13, 2017 |
|
1785 |
Increase, Mitochondrial ATP synthase antagonism |
Molecular |
May 8, 2020 |
Dec 4, 2020 |
- Mitochondrial ATP synthase antagonism leading to growth inhibition (1)
- Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
|
1813 |
Increase, Mitochondrial complex I dysfunction |
Molecular |
Nov 2, 2020 |
Nov 2, 2020 |
|
1542 |
Increase, Mitochondrial complex III antagonism |
Molecular |
Dec 19, 2018 |
Dec 4, 2020 |
- Mitochondrial complex inhibition leading to liver injury
- Mitochondrial complex III antagonism leading to growth inhibition (1)
- Mitochondrial complex III antagonism leading to growth inhibition (2)
|
1811 |
Increase, Mitochondrial complex III dysfunction |
Molecular |
Nov 2, 2020 |
Nov 2, 2020 |
|
2072 |
Increase, Mitochondrial swelling |
Cellular |
Nov 1, 2022 |
Nov 1, 2022 |
- Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
|
350 |
Increase, Mortality |
Individual |
Nov 29, 2016 |
Oct 26, 2020 |
- Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
- Excessive reactive oxygen species production leading to mortality (1)
- Excessive reactive oxygen species production leading to mortality (2)
- Excessive reactive oxygen species production leading to mortality (3)
- S-adenosylmethionine depletion leading to population decline (2)
- S-adenosylmethionine depletion leading to population decline (1)
- Chitinase inhibition leading to mortality
- Chitobiase inhibition leading to mortality
- Chitin synthase 1 inhibition leading to mortality
- Sulfonylureareceptor binding leading to mortality
- Alcohol dehydrogenase leading to reproductive dysfunction
- Doda decarboxylase leading to mortality
- Knickkopf leading to mortality
- Various neuronal effects induced by elavl3, sox10, and mbp
- Excessive reactive oxygen species production leading to mortality (4)
|
962 |
Increase, Mucin production |
Cellular |
Nov 29, 2016 |
Mar 9, 2023 |
- EGFR Activation Leading to Decreased Lung Function
|
1374 |
Increase, mucosal blood flow |
Tissue |
Apr 17, 2017 |
Apr 17, 2017 |
|
1373 |
Increase, mucous |
Molecular |
Apr 17, 2017 |
Apr 17, 2017 |
|
185 |
Increase, Mutations |
Molecular |
Nov 29, 2016 |
May 15, 2023 |
- Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
- Alkylation of DNA leading to cancer 2
- Alkylation of DNA leading to cancer 1
- Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
- Increased DNA damage leading to increased risk of breast cancer
- Oxidative DNA damage leading to chromosomal aberrations and mutations
- Deposition of energy leading to lung cancer
- Bulky DNA adducts leading to mutations
- DNA damage and mutations leading to Metastatic Breast Cancer
- Deposition of energy leading to occurrence of cataracts
|
876 |
Increase, Mutations in Critical Genes |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
- Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
|
1341 |
Increase, myosin light chain phosphorylation |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
1607 |
Increase, Necrosis |
Tissue |
Mar 19, 2019 |
Mar 19, 2019 |
- Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
|
733 |
Increase, Necrosis (terminal bronchiolar cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
|
1578 |
Increase, Necrotic tissue |
Tissue |
Jan 7, 2019 |
Jan 7, 2019 |
|
1264 |
Increase, Nuclear receptor E75b gene expression |
Molecular |
Feb 9, 2017 |
May 24, 2018 |
- Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
|
1775 |
Increase, Oocyte apoptosis |
Cellular |
Apr 30, 2020 |
Apr 30, 2020 |
- DNA methyltransferase inhibition leading to population decline (1)
- DNA methyltransferase inhibition leading to population decline (3)
- Deposition of ionizing energy leads to population decline via impaired meiosis
- Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis
- Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
|
1780 |
Increase, Oocyte apoptosis (F3) |
Cellular |
Apr 30, 2020 |
Apr 30, 2020 |
- DNA methyltransferase inhibition leading to transgenerational effects (1)
|
1526 |
Increase, Opening of voltage-dependent calcium channel |
Cellular |
May 24, 2018 |
May 24, 2018 |
- S-adenosylmethionine depletion leading to population decline (2)
- Sulfonylureareceptor binding leading to mortality
|
1777 |
Increase, Ovarian follicle breakdown |
Organ |
Apr 30, 2020 |
Apr 30, 2020 |
- DNA methyltransferase inhibition leading to population decline (2)
- DNA methyltransferase inhibition leading to population decline (4)
|
1784 |
Increase, Ovarian follicle breakdown (F3) |
Organ |
Apr 30, 2020 |
Apr 30, 2020 |
- DNA methyltransferase inhibition leading to transgenerational effects (2)
|
1776 |
Increase, Ovarian somatic cell apoptosis |
Cellular |
Apr 30, 2020 |
Apr 30, 2020 |
- DNA methyltransferase inhibition leading to population decline (2)
- DNA methyltransferase inhibition leading to population decline (4)
|
1783 |
Increase, Ovarian somatic cell apoptosis (F3) |
Cellular |
Apr 30, 2020 |
Apr 30, 2020 |
- DNA methyltransferase inhibition leading to transgenerational effects (2)
|
1634 |
Increase, Oxidative DNA damage |
Molecular |
May 19, 2019 |
Oct 8, 2024 |
- Oxidative DNA damage leading to chromosomal aberrations and mutations
- Deposition of energy leading to population decline via DNA oxidation and follicular atresia
- Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
- Deposition of energy leading to occurrence of cataracts
- Excessive reactive oxygen species production leading to mortality (4)
- Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death
- Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage and reduced cell proliferation
|
769 |
Increase, Oxidative metabolism |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
|
1969 |
Increase, Oxidative Stress |
Molecular |
Feb 4, 2022 |
Mar 3, 2022 |
- Activation of reactive oxygen species leading the atherosclerosis
|
1279 |
Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
|
1826 |
Increase, Oxygen consumption |
Cellular |
Dec 4, 2020 |
Dec 4, 2020 |
|
1865 |
Increase, Oxygen-evolving complex damage |
Molecular |
Apr 11, 2021 |
Apr 11, 2021 |
- Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
|
779 |
Increase, Papillomas/carcinomas (squamous cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
- Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
|
358 |
Increase, Pericardial edema |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
|
1173 |
Increase, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
|
1170 |
Increase, Phenotypic enzyme activity |
Cellular |
Nov 29, 2016 |
Dec 28, 2020 |
- PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
|
1892 |
increase, placental insufficiency |
Organ |
May 31, 2021 |
May 31, 2021 |
- AhR activation leading to preeclampsia
|
220 |
Increase, Plasma vitellogenin concentrations |
Organ |
Nov 29, 2016 |
Jun 24, 2024 |
- Estrogen receptor agonism leading to reproductive dysfunction
- ER agonism leading to reduced survival due to renal failure
- Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
- Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
|
1375 |
Increase, platelet aggregation |
Tissue |
Apr 17, 2017 |
Apr 17, 2017 |
|
1993 |
Increase, Pneumonia |
Organ |
Apr 7, 2022 |
Apr 7, 2022 |
|
1965 |
Increase, Pollen abnormal |
Organ |
Jan 13, 2022 |
Jan 13, 2022 |
- Deposition of ionising energy leads to population decline via pollen abnormal
|
623 |
Increase, predation |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
|
1893 |
increase, Preeclampsia |
Individual |
May 31, 2021 |
May 31, 2021 |
- AhR activation leading to preeclampsia
|
1524 |
Increase, Premature molting |
Individual |
May 24, 2018 |
Feb 17, 2021 |
- S-adenosylmethionine depletion leading to population decline (2)
- S-adenosylmethionine depletion leading to population decline (1)
- Chitinase inhibition leading to mortality
- Chitobiase inhibition leading to mortality
- Chitin synthase 1 inhibition leading to mortality
- Sulfonylureareceptor binding leading to mortality
|
774 |
Increase, Preneoplastic foci (hepatocytes) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
- Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
- Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
|
2097 |
Increase, Pro-Inflammatory Mediators |
Tissue |
Jan 25, 2023 |
Jul 26, 2024 |
- Deposition of Energy Leading to Learning and Memory Impairment
|
1864 |
Increase, Programmed cell death |
Cellular |
Apr 11, 2021 |
Apr 12, 2021 |
- Deposition of ionising energy leading to population decline via programmed cell death
|
1579 |
Increase, proinflammatory mediators (TNFalpha) |
Molecular |
Jan 7, 2019 |
Jan 7, 2019 |
- IKK complex inhibition leading to liver injury
|
923 |
Increase, Proliferation of goblet cells |
Cellular |
Nov 29, 2016 |
Aug 20, 2021 |
|
1767 |
Increase, Protein oxidation |
Molecular |
Apr 30, 2020 |
Apr 30, 2020 |
- Excessive reactive oxygen species production leading to mortality (1)
- Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell death
|
2077 |
Increase, pulmonate breathing |
Individual |
Nov 16, 2022 |
Nov 16, 2022 |
- Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
|
246 |
Increase, RBC congestion in liver |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Oxidation of iron in hemoglobin leading to hematotoxicity
|
257 |
Increase, Reactive Oxygen Species |
Molecular |
Nov 29, 2016 |
Oct 8, 2024 |
- Calcium-mediated neuronal ROS production and energy imbalance
- Excessive reactive oxygen species production leading to mortality (1)
- Excessive reactive oxygen species production leading to mortality (2)
- Excessive reactive oxygen species production leading to mortality (3)
- Excessive reactive oxygen species production leading to mortality (4)
- Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
- Deposition of energy leading to population decline via DNA oxidation and follicular atresia
- Increased reactive oxygen species production leading to decreased cognitive function
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
- Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress
- Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death
- Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death
- Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell death
- Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage and reduced cell proliferation
- Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation
- Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation
- Activation of reactive oxygen species leading the atherosclerosis
|
1364 |
Increase, Reactive oxygen species formation |
Molecular |
Apr 15, 2017 |
Oct 8, 2024 |
- Deposition of ionizing energy leads to population decline via impaired meiosis
- AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
- AhR activation leading to liver fibrosis
|
778 |
Increase, Regenerative cell proliferation (corneal cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
|
781 |
Increase, Regenerative cell proliferation (forestomach epithelial cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
|
787 |
Increase, Regenerative cell proliferation (hepatocytes) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
|
734 |
Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
|
710 |
Increase, Regenerative cell proliferation (tubular epithelial cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
- Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
|
795 |
Increase, Regenerative cell proliferation (urothelial cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
- AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
|
252 |
Increase, Renal pathology due to VTG deposition |
Organ |
Nov 29, 2016 |
Jun 24, 2024 |
- Estrogen receptor agonism leading to reproductive dysfunction
- Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
|
869 |
Increase, Respiratory or Squamous Metaplasia |
Tissue |
Nov 29, 2016 |
Sep 29, 2017 |
- Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
|
1652 |
Increase, S-adenosylmethionine depletion |
Molecular |
May 30, 2019 |
May 30, 2019 |
|
1348 |
Increase, seizure |
Individual |
Apr 14, 2017 |
Apr 14, 2017 |
- Molecular events lead to epilepsy
- Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1315 |
Increase, Selective Serotonin Reuptake Inhibitors (SSRIs) |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
|
2049 |
Increase, sex ratio (F/M) |
Individual |
Aug 28, 2022 |
Aug 28, 2022 |
- Alcohol dehydrogenase leading to reproductive dysfunction
|
872 |
Increase, Site of Contact Nasal Tumors |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
- Cytochrome oxidase inhibition leading to olfactory nasal lesions
|
2021 |
Increase, slincR expression |
Molecular |
Jun 29, 2022 |
Aug 1, 2022 |
- Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
- Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
|
1525 |
Increase, Sulfonylurea receptor binding |
Molecular |
May 24, 2018 |
May 24, 2018 |
- S-adenosylmethionine depletion leading to population decline (2)
- Sulfonylureareceptor binding leading to mortality
|
1381 |
Increase, surfactant |
Molecular |
Apr 17, 2017 |
Apr 17, 2017 |
|
1748 |
Increase, the risk of acute respiratory failure |
Organ |
Mar 10, 2020 |
Mar 10, 2020 |
- Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
|
753 |
Increase, Thyroid-stimulating hormone (TSH) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
|
868 |
Increase, Tissue Degeneration, Necrosis & Atrophy |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
|
1809 |
Increase, Tissue/organ damage |
Organ |
Nov 2, 2020 |
Nov 2, 2020 |
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
|
1950 |
Increase, TNF |
Molecular |
Nov 18, 2021 |
Nov 18, 2021 |
- Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
|
1471 |
Increase, Uncoupling of photophosphorylation |
Cellular |
Oct 10, 2017 |
Oct 10, 2017 |
- Reduction in photophosphorylation leading to growth inhibition in aquatic plants
|
793 |
Increase, Urinary bladder calculi |
Organ |
Nov 29, 2016 |
Oct 26, 2017 |
- Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
|
2161 |
Increase, Vascular disrupting effects |
Individual |
Aug 19, 2023 |
Aug 19, 2023 |
- Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway
- Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
- Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
- Demethylation of PPAR promotor leading to vascular disrupting effects
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
- Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
|
1342 |
Increase, vascular smooth muscle contraction |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
2046 |
Increase, Vitellogenin mRNA |
Molecular |
Aug 28, 2022 |
Aug 28, 2022 |
- Alcohol dehydrogenase leading to reproductive dysfunction
|
307 |
Increase, Vitellogenin synthesis in liver |
Tissue |
Nov 29, 2016 |
Jun 24, 2024 |
- Estrogen receptor agonism leading to reproductive dysfunction
- Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
- Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
|
1745 |
Increase,collagen synthesis |
Cellular |
Mar 10, 2020 |
Mar 10, 2020 |
|
1888 |
Increased (ectopic) all-trans retinoic acid concentration |
Tissue |
May 29, 2021 |
Nov 11, 2021 |
- Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males
|
1948 |
Increased ACE2 expression |
Molecular |
Oct 28, 2021 |
Oct 28, 2021 |
- SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
|
1172 |
Increased activation, Nuclear factor kappa B (NF-kB) |
Cellular |
Nov 29, 2016 |
Aug 27, 2023 |
- Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Binding to ACE2 leading to lung fibrosis
- DNA damage and mutations leading to Metastatic Breast Cancer
|
1039 |
Increased activity, beta-2 adrenergic receptor |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
|
2128 |
Increased adipocyte numbers |
Cellular |
Apr 5, 2023 |
Apr 5, 2023 |
- ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
|
2127 |
Increased adipocyte size |
Cellular |
Apr 5, 2023 |
Apr 5, 2023 |
- ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
|
1449 |
increased adipogenesis |
Tissue |
Jul 24, 2017 |
Jul 24, 2017 |
- Epigenetic modification of PPARG leading to adipogenesis
|
1852 |
Increased Ang II type 1 receptor (AT1R) |
Tissue |
Mar 30, 2021 |
Mar 30, 2021 |
- Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
- Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
|
1752 |
Increased Angiotensin II |
Cellular |
Mar 17, 2020 |
Apr 4, 2021 |
- Binding to ACE2 leading to lung fibrosis
- Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
- Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
- Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
|
1026 |
Increased Apoptosis, Adenomas/carcinomas (follicular cell) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
|
496 |
Increased apoptosis, decreased fetal/adult Leydig Cells |
Cellular |
Nov 29, 2016 |
May 17, 2023 |
- Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
|
1722 |
Increased blood CCK level |
Organ |
Jan 8, 2020 |
Jan 8, 2020 |
- Trypsin inhibition leading to pancreatic acinar cell tumors
|
1663 |
Increased brain Homocysteine level |
Organ |
Jun 14, 2019 |
Jun 14, 2019 |
|
1433 |
Increased CGRP, neuronal release of CGRP |
Cellular |
Jun 23, 2017 |
Sep 16, 2017 |
- Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
|
39 |
Increased Cholinergic Signaling |
Organ |
Nov 29, 2016 |
Dec 20, 2019 |
- Acetylcholinesterase inhibition leading to acute mortality
- Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
- Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
|
1723 |
Increased exocrine secretion from pancreatic acinar cells |
Cellular |
Jan 8, 2020 |
Jan 8, 2020 |
- Trypsin inhibition leading to pancreatic acinar cell tumors
|
2125 |
Increased fat mass |
Organ |
Apr 5, 2023 |
Apr 5, 2023 |
- ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
|
1661 |
Increased Homocysteine level |
Cellular |
Jun 14, 2019 |
Jun 14, 2019 |
- Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
|
2235 |
Increased incidence and mortality of liver diseases among children |
Population |
Jun 26, 2024 |
Jun 26, 2024 |
|
1929 |
Increased incidence of cardiovascular morbidity and mortality in the general population |
Population |
Aug 21, 2021 |
Aug 21, 2021 |
|
2247 |
Increased incidence of cerebrovascular morbidility and mortality in the general population |
Population |
Jul 29, 2024 |
Jul 29, 2024 |
|
1996 |
Increased incidence of digestive morbidity and mortality in the general population |
Population |
Apr 7, 2022 |
Apr 7, 2022 |
|
2087 |
Increased incidence of respiratory disease |
Individual |
Jan 9, 2023 |
Jan 9, 2023 |
- AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
|
1992 |
Increased incidence of respiratory morbidity and mortality in the general population |
Population |
Apr 7, 2022 |
Apr 7, 2022 |
|
2183 |
Increased incidence of vascular calcification and atherosclerosis morbidity |
Population |
Sep 4, 2023 |
Nov 14, 2023 |
|
1750 |
Increased inflammatory immune responses |
Tissue |
Mar 10, 2020 |
Jan 21, 2021 |
- Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
- SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
|
1721 |
Increased intestinal monitor peptide level |
Organ |
Jan 8, 2020 |
Jan 8, 2020 |
- Trypsin inhibition leading to pancreatic acinar cell tumors
|
2149 |
Increased intracelluar Iron accumulation |
Cellular |
Jun 15, 2023 |
Jun 15, 2023 |
- Increased LCN2/iron complex leading to neurological disorders
- Excessive iron accumulation leading to neurological disorders
|
2148 |
Increased LCN2/iron complex binds to SLC22A17 receptor in neuron |
Molecular |
Jun 15, 2023 |
Jun 15, 2023 |
- Increased LCN2/iron complex leading to neurological disorders
|
2130 |
increased lipid accumulation |
Cellular |
Apr 5, 2023 |
Apr 5, 2023 |
- ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
|
1256 |
increased mantel display |
Organ |
Jan 13, 2017 |
Jan 13, 2017 |
- 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
- 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
|
1980 |
Increased microRNA expression |
Cellular |
Mar 22, 2022 |
Aug 27, 2023 |
- DNA damage and mutations leading to Metastatic Breast Cancer
|
2081 |
Increased Modified Proteins |
Molecular |
Dec 16, 2022 |
Mar 8, 2024 |
- Deposition of energy leading to occurrence of cataracts
|
2156 |
Increased morbidity of congenital heart defect |
Population |
Jul 31, 2023 |
Jul 31, 2023 |
|
351 |
Increased Mortality |
Population |
Nov 29, 2016 |
Jul 8, 2022 |
- Acetylcholinesterase inhibition leading to acute mortality
- Axonal sodium channel modulation leading to acute mortality
- Altered ion channel activity leading impaired heart function
- Glutamate-gated chloride channel activation leading to acute mortality
- Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
- Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
- Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
- Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
- unknown MIE leading to renal failure and mortality
- Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
- Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
- Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
- Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
- Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Thyroperoxidase inhibition leading to altered visual function via decreased eye size
- Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
- Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
- Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
- GSK3beta inactivation leading to increased mortality via defects in developing inner ear
- Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
- Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
|
1999 |
Increased mortality of neurodegenerative diseases |
Population |
Apr 7, 2022 |
Apr 7, 2022 |
|
1897 |
increased MyD88 activation |
Molecular |
Jul 8, 2021 |
Jul 8, 2021 |
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
|
1435 |
Increased neurokinin A (NKA) by neuronal cells |
Cellular |
Jun 23, 2017 |
Sep 16, 2017 |
- Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
|
1147 |
increased or inappropriate, mantel display |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
|
1662 |
Increased plasma Homocysteine level |
Tissue |
Jun 14, 2019 |
Jun 14, 2019 |
|
1900 |
increased platelet surface TLR9 expression |
Cellular |
Jul 8, 2021 |
Jul 8, 2021 |
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
|
2132 |
Increased pro-inflammatory cytokine expression |
Cellular |
Apr 6, 2023 |
Apr 6, 2023 |
- ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
|
1493 |
Increased Pro-inflammatory mediators |
Tissue |
Nov 28, 2017 |
Sep 17, 2024 |
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
- Protein Alkylation leading to Liver Fibrosis
- Endocytic lysosomal uptake leading to liver fibrosis
- Increased DNA damage leading to increased risk of breast cancer
- Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
- Deposition of energy leads to abnormal vascular remodeling
|
1546 |
Increased reactive oxygen species (in the mitochondria) |
Cellular |
Dec 19, 2018 |
Dec 19, 2018 |
- Mitochondrial complex inhibition leading to liver injury
|
1898 |
increased release of danger/damage associated molecular patterns |
Tissue |
Jul 8, 2021 |
Jul 8, 2021 |
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
|
1226 |
Increased Respiratory irritability and Chronic Cough, |
Organ |
Nov 29, 2016 |
Sep 24, 2018 |
- Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
|
1847 |
Increased SARS-CoV-2 production |
Cellular |
Mar 25, 2021 |
Jun 14, 2022 |
- Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
- Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
- SARS-CoV-2 infection leading to hyperinflammation
- SARS-CoV-2 infection leading to pyroptosis
- Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption
- Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
- SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
- Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
|
1855 |
Increased Sodium-sensitive hypertension |
Tissue |
Apr 7, 2021 |
Apr 7, 2021 |
- Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
|
2033 |
Increased sphingolipid-1-phosphate |
Cellular |
Jul 19, 2022 |
Jul 19, 2022 |
- Ceramide synthase inhibition leading to neural tube defects
|
2248 |
Increased stress hormone |
Cellular |
Jul 29, 2024 |
Jul 29, 2024 |
|
1460 |
Increased Substance P (SP) by goblet cells |
Cellular |
Jul 27, 2017 |
Jul 27, 2017 |
|
2246 |
Increased sympathetic nerve activity |
Cellular |
Jul 29, 2024 |
Jul 29, 2024 |
|
1441 |
Increased systemic total cholesterol pool |
Organ |
Jun 29, 2017 |
Jun 29, 2017 |
|
1858 |
Increased viral transcription and replication |
Cellular |
Apr 9, 2021 |
Apr 9, 2021 |
|
1030 |
Increased, |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1326 |
Increased, 5-HT3 (5-hydroxytryptamine) |
Molecular |
Apr 13, 2017 |
Jun 1, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
|
708 |
Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
|
134 |
Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
|
1499 |
Increased, activation of T (T) helper (h) type 2 cells |
Tissue |
Jan 3, 2018 |
May 12, 2023 |
- Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
|
1082 |
Increased, adenomas (pituitary) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
|
1079 |
Increased, Adenomas/carcinomas (mammary) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
- Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
|
1070 |
Increased, adenosquamous carcinomas of endometrium |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
|
1029 |
Increased, adipogenesis |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARgamma activation leading to sarcomas in rats, mice, and hamsters
|
1345 |
Increased, agitation |
Molecular |
Apr 13, 2017 |
Jun 1, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Mental stress to agitation
- Serotonin transporter activation to agitation
|
591 |
Increased, amputations |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Sodium channel inhibition leading to congenital malformations
|
1213 |
Increased, Angiogenesis |
Cellular |
Nov 29, 2016 |
Dec 20, 2022 |
- Estrogen receptor activation leading to breast cancer
|
880 |
Increased, ApoB100 |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- NFE2L2/FXR activation leading to hepatic steatosis
|
574 |
Increased, Appetite and hunger |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
|
602 |
Increased, Ataxia, paralysis, or hyperactivity |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Axonal sodium channel modulation leading to acute mortality
|
444 |
Increased, Atrioventricular block and bradycardia |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Sodium channel inhibition leading to congenital malformations
|
2124 |
increased, Bax expression |
Molecular |
Apr 4, 2023 |
Sep 7, 2023 |
- Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
|
714 |
Increased, Binding of chemicals to 2u (serum) |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
|
1098 |
Increased, blood potassium concentration |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
- Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
- unknown MIE leading to renal failure and mortality
|
1096 |
Increased, blood uric acid concentration |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
- Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
|
2238 |
Increased, Blood viscosity |
Tissue |
Jul 8, 2024 |
Sep 26, 2024 |
- Decreased Sodium/Potassium ATPase activity leads to Heart failure
|
699 |
Increased, cardiac arrthymia |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Altered ion channel activity leading impaired heart function
|
2239 |
Increased, Cardiac stress |
Organ |
Jul 8, 2024 |
Sep 27, 2024 |
- Decreased Sodium/Potassium ATPase activity leads to Heart failure
|
863 |
Increased, Catabolism of Muscle Protein |
Organ |
Nov 29, 2016 |
Apr 30, 2019 |
- Antagonist binding to PPARα leading to body-weight loss
|
1089 |
Increased, Cell Proliferation (mesothelium) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
|
1062 |
Increased, Cellular proliferation / hyperplasia of acinar cells |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
|
761 |
Increased, Chloride conductance |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Glutamate-gated chloride channel activation leading to acute mortality
- Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
- Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
|
1011 |
Increased, Chloride influx |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1059 |
Increased, cholestasis |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
|
2270 |
Increased, cholesterol synthesis enzymes |
Cellular |
Oct 22, 2024 |
Oct 22, 2024 |
- Activation, Pregnane-X receptor, NR1l2 leads to Increased, plasma low-density lipoprotein (LDL) cholesterol
|
696 |
Increased, Chromosome misseggregation |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
|
1162 |
Increased, cilia movement |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
|
1076 |
Increased, circulating estrogen levels |
Organ |
Nov 29, 2016 |
Dec 3, 2016 |
- GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
- GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
- Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
|
961 |
Increased, Clearance of thyroxine from serum |
Tissue |
Nov 29, 2016 |
Jan 26, 2021 |
- Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
- Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
- Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
- Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
- Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
- AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
|
384 |
Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
423 |
Increased, Clonal Expansion / Cell Proliferation to Form Pre-Neoplastic Altered Hepatic Foci |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
693 |
Increased, cyclic adenosine monophosphate |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
|
458 |
Increased, De Novo FA synthesis |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- NR1I3 (CAR) suppression leading to hepatic steatosis
- NFE2L2/FXR activation leading to hepatic steatosis
|
1109 |
Increased, Deformed Wing Virus levels |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Varroa mite infestation increases virus levels leading to colony loss/failure
|
1346 |
Increased, depression |
Individual |
Apr 13, 2017 |
Jun 1, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Mental stress to depression
- Serotonin transporter activation to depression
|
1001 |
Increased, Developmental Defects |
Molecular |
Nov 29, 2016 |
Aug 31, 2023 |
- Disruption of VEGFR Signaling Leading to Developmental Defects
|
1790 |
Increased, Differentiation to Testis |
Tissue |
Jun 15, 2020 |
Dec 28, 2022 |
- Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
- Androgen receptor agonism leading to male-biased sex ratio
|
323 |
Increased, Disease susceptibility |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
|
1669 |
Increased, DNA damage and mutation |
Cellular |
Jul 3, 2019 |
Aug 13, 2019 |
- Frustrated phagocytosis-induced lung cancer
- Frustrated phagocytosis leads to malignant mesothelioma
- Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
- Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway
- DNA damage and mutations leading to Metastatic Breast Cancer
- Interaction with lung resident cell membrane components leads to lung cancer
|
1281 |
Increased, DNA Damage-Repair |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
|
1192 |
Increased, Ductal Hyperplasia |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Estrogen receptor activation leading to breast cancer
- Increased DNA damage leading to increased risk of breast cancer
- Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
|
1110 |
Increased, Energetic demands and therefore metabolic stress |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Nosema infection increases energetic demands leading to colony loss/failure
|
1363 |
Increased, epilepsy |
Individual |
Apr 14, 2017 |
Jun 2, 2017 |
- Molecular events lead to epilepsy
- presynaptic neuron 1 activation to epilepsy
- presynaptic neuron 2 repression to epilepsy
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1187 |
Increased, ER binding to DNA (classical pathway) |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Estrogen receptor activation leading to breast cancer
|
1188 |
Increased, ER binding to T.F. to DNA (non-classical pathway) |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Estrogen receptor activation leading to breast cancer
|
2205 |
Increased, essential element imbalance |
Molecular |
Jan 24, 2024 |
May 9, 2024 |
- Essential element imbalance leads to reproductive failure via oxidative stress
|
748 |
Increased, Estrogen receptor (ER) activity |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
- Alcohol dehydrogenase leading to reproductive dysfunction
|
1973 |
Increased, estrogens |
Cellular |
Feb 25, 2022 |
Mar 1, 2022 |
- Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
- SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
|
2199 |
Increased, Expression of LXR activated genes |
Molecular |
Dec 7, 2023 |
Mar 29, 2024 |
- Liver X Receptor (LXR) activation leads to liver steatosis
|
1501 |
Increased, extracellular matrix deposition |
Tissue |
Jan 5, 2018 |
Jan 25, 2022 |
- Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
- Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway
- Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway
- AhR activation leading to liver fibrosis
|
1320 |
Increased, extracellular serotonin |
Molecular |
Apr 13, 2017 |
May 31, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Mental stress to depression
- Mental stress to agitation
- Serotonin transporter activation to seizure
- Serotonin transporter activation to depression
- Serotonin transporter activation to agitation
- SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
465 |
Increased, FA Influx |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- AhR activation leading to hepatic steatosis
- NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
- NR1I3 (CAR) suppression leading to hepatic steatosis
|
460 |
Increased, Fatty acid uptake |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
|
1500 |
Increased, fibroblast proliferation and myofibroblast differentiation |
Tissue |
Jan 5, 2018 |
May 17, 2023 |
- Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
|
1035 |
Increased, Firbrosarcoma |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARgamma activation leading to sarcomas in rats, mice, and hamsters
|
624 |
Increased, foot detachment |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
|
959 |
Increased, Free serum thyroxine (T4) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
- Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
- Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
|
2143 |
Increased, gene expression of AR |
Molecular |
May 18, 2023 |
May 18, 2023 |
- Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
|
421 |
Increased, glomerular rupture and renal hemorrhaging |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- ER agonism leading to reduced survival due to renal failure
|
1396 |
Increased, glucocorticoid receptor activity |
Molecular |
May 31, 2017 |
May 31, 2017 |
- Mental stress to depression
- Mental stress to agitation
|
1350 |
Increased, glutamate |
Molecular |
Apr 14, 2017 |
Oct 11, 2021 |
- Molecular events lead to epilepsy
- presynaptic neuron 1 activation to epilepsy
- Acetylcholinesterase Inhibition Leading to Neurodegeneration
- Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
|
2079 |
Increased, glycolipid levels |
Cellular |
Dec 13, 2022 |
May 17, 2023 |
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
|
1037 |
Increased, hemagiosarcoma |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARgamma activation leading to sarcomas in rats, mice, and hamsters
|
1158 |
Increased, Hepatic thyroid hormone uptake/transport |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
- Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
- Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
- AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation
|
802 |
Increased, HIF-1 alpha transcription |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
|
799 |
Increased, HIF-1 heterodimer |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
- Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
|
1362 |
Increased, hippocampal hyperdepolarization |
Molecular |
Apr 14, 2017 |
Jun 2, 2017 |
- Molecular events lead to epilepsy
- presynaptic neuron 1 activation to epilepsy
- presynaptic neuron 2 repression to epilepsy
|
2206 |
Increased, histomorphological alteration of testis |
Tissue |
Jan 24, 2024 |
Apr 10, 2024 |
- Essential element imbalance leads to reproductive failure via oxidative stress
|
1025 |
Increased, Hyperplasia (follicular cells) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
|
1069 |
Increased, Hyperplasia (glandular epithelial cells of endometrium) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
|
1085 |
Increased, hyperplasia (mammary gland) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
|
1024 |
Increased, Hypertrophy and proliferation (follicular cell) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
|
1034 |
Increased, IGF-1 (mouse) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARgamma activation leading to sarcomas in rats, mice, and hamsters
|
376 |
Increased, Induced Mutations in Critical Genes |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
|
726 |
Increased, Induction of pyruvate dehydrogenase (PDH) |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
|
1020 |
Increased, induction of UDPGT's in liver |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
|
1087 |
Increased, inflammation |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
|
1012 |
Increased, Inhibitory postsynaptic potential |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
- Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
- Various neuronal effects induced by elavl3, sox10, and mbp
|
493 |
Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
|
1933 |
Increased, Interleukin-6 production |
Cellular |
Sep 20, 2021 |
Sep 20, 2021 |
- Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
|
389 |
Increased, Intracellular Calcium overload |
Cellular |
Nov 29, 2016 |
Jun 26, 2020 |
- Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
- Acetylcholinesterase Inhibition Leading to Neurodegeneration
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
- Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
- Binding and activation of GPER leading to learning and memory impairments
|
1322 |
Increased, intracellular chloride (Cl-) |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Molecular events lead to epilepsy
|
1398 |
Increased, intracellular serotonin |
Cellular |
Jun 1, 2017 |
Jun 1, 2017 |
- Serotonin transporter activation to seizure
- Serotonin transporter activation to depression
- Serotonin transporter activation to agitation
|
1321 |
Increased, intracellular sodium (Na+) |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Molecular events lead to epilepsy
- presynaptic neuron 1 activation to epilepsy
|
1196 |
Increased, Invasion |
Cellular |
Nov 29, 2016 |
Feb 29, 2024 |
- Estrogen receptor activation leading to breast cancer
- Activation of the AhR leading to metastatic breast cancer
- Androgen receptor activation leading to prostate cancer
|
759 |
Increased, Kidney Failure |
Population |
Nov 29, 2016 |
Jan 16, 2019 |
- Kidney toxicity induced by activation of 5HT2C
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
- Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
|
1985 |
Increased, Kisspeptin signalling |
Molecular |
Apr 5, 2022 |
Apr 5, 2022 |
- Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
|
1081 |
Increased, lactotroph hyperplasia and hypertrophy |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
|
1080 |
Increased, latency period |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
- Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
|
467 |
Increased, LDL uptake |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- AhR activation leading to hepatic steatosis
|
342 |
Increased, Lethality |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1411 |
Increased, leukocyte activation |
Tissue |
Jun 2, 2017 |
Jun 2, 2017 |
- NSAID induced PTGS2 inactivation to gastric ulcer
|
1410 |
Increased, leukocyte adherence |
Tissue |
Jun 2, 2017 |
Jun 2, 2017 |
- NSAID induced PTGS2 inactivation to gastric ulcer
|
791 |
Increased, Leutinizing hormone (LH) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
|
1306 |
Increased, lipogenesis |
Molecular |
Apr 12, 2017 |
Apr 12, 2017 |
|
1036 |
Increased, liposarcoma |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARgamma activation leading to sarcomas in rats, mice, and hamsters
|
459 |
Increased, Liver Steatosis |
Organ |
Nov 29, 2016 |
May 21, 2024 |
- NR1I3 (CAR) suppression leading to hepatic steatosis
- NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
- NFE2L2/FXR activation leading to hepatic steatosis
- AKT2 activation leading to hepatic steatosis
- Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
- Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
- Inhibition of N-linked glycosylation leads to liver injury
- Glucocorticoid Receptor activation leading to hepatic steatosis
- Pregnane X Receptor (PXR) activation leads to liver steatosis
- Liver X Receptor (LXR) activation leads to liver steatosis
- Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
- NFE2/Nrf2 repression to steatosis
- AhR activation leading to hepatic steatosis
- AhR activation leading to liver fibrosis
|
622 |
Increased, locomotion |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
|
754 |
Increased, Luteinizing hormone (LH) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
|
1791 |
Increased, Male Biased Sex Ratio |
Population |
Jun 15, 2020 |
Jan 3, 2023 |
- Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
- Androgen receptor agonism leading to male-biased sex ratio
|
1208 |
Increased, Male offspring |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Juvenile hormone receptor agonism leading to male offspring induction associated population decline
|
1160 |
Increased, mantel display |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
|
1090 |
Increased, mesotheliomas |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
- Frustrated phagocytosis leads to malignant mesothelioma
|
1190 |
Increased, Migration (Endothelial Cells) |
Cellular |
Nov 29, 2016 |
Feb 29, 2024 |
- Estrogen receptor activation leading to breast cancer
- Activation of the AhR leading to metastatic breast cancer
|
1241 |
Increased, Motility |
Cellular |
Nov 29, 2016 |
Feb 28, 2024 |
- Estrogen receptor activation leading to breast cancer
- Activation of the AhR leading to metastatic breast cancer
|
625 |
Increased, muscular waves in foot |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
|
422 |
Increased, nephropathy |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- ER agonism leading to reduced survival due to renal failure
|
1015 |
Increased, Neuronal synaptic inhibition |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
- Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1191 |
Increased, Non-genomic signaling |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Estrogen receptor activation leading to breast cancer
|
1491 |
Increased, Oncotic Necrosis |
Tissue |
Nov 14, 2017 |
Nov 27, 2017 |
- Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
|
1990 |
Increased, Oocyte Atresia |
Tissue |
Apr 5, 2022 |
Apr 5, 2022 |
- Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
|
1161 |
Increased, oocyte maturation |
Organ |
Nov 29, 2016 |
Jan 17, 2017 |
- 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
|
356 |
Increased, Oxidative damage |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
|
1088 |
Increased, Oxidative Stress |
Molecular |
Nov 29, 2016 |
Feb 3, 2022 |
- Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress
|
1399 |
Increased, packaged serotonin |
Cellular |
Jun 1, 2017 |
Jun 1, 2017 |
- Serotonin transporter activation to seizure
- Serotonin transporter activation to depression
- Serotonin transporter activation to agitation
|
1063 |
Increased, Pancreatic acinar tumors |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
|
1665 |
Increased, Plasma HCY level |
Tissue |
Jul 3, 2019 |
Jul 3, 2019 |
- Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
|
2271 |
Increased, plasma low-density lipoprotein (LDL) cholesterol |
Tissue |
Oct 22, 2024 |
Oct 22, 2024 |
- Activation, Pregnane-X receptor, NR1l2 leads to Increased, plasma low-density lipoprotein (LDL) cholesterol
|
775 |
Increased, Plasma tyrosine |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
|
1164 |
Increased, Population |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
- 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
|
1057 |
Increased, PPAR-alpha activation |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
|
588 |
Increased, predation |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- sodium channel inhibition leading to increased predation
- Sodium channel inhibition leading to reduced survival
- Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
- Histamine (H2) receptor antagonism leading to reduced survival
|
1577 |
Increased, proinflammatory mediators (TNFalpha) |
Molecular |
Jan 7, 2019 |
Jan 7, 2019 |
|
1077 |
Increased, prolactin exposure |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
|
1084 |
Increased, prolactin secretion |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
|
1189 |
Increased, Proliferation (Endothelial cells) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Estrogen receptor activation leading to breast cancer
|
1033 |
Increased, proliferation of mesenchymal cells |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARgamma activation leading to sarcomas in rats, mice, and hamsters
|
377 |
Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered Hepatic Foci (AHF)) |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1357 |
Increased, RDX dose |
Molecular |
Apr 14, 2017 |
Jun 2, 2017 |
- Molecular events lead to epilepsy
- presynaptic neuron 2 repression to epilepsy
|
1922 |
Increased, Reactive metabolites production |
Cellular |
Aug 19, 2021 |
Aug 26, 2021 |
- Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway
|
1115 |
Increased, Reactive oxygen species |
Cellular |
Nov 29, 2016 |
Apr 10, 2024 |
- unknown MIE leading to renal failure and mortality
- Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
- Frustrated phagocytosis-induced lung cancer
- Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
- Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis
- Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
- Deposition of ionizing energy leads to population decline via impaired meiosis
- Frustrated phagocytosis leads to malignant mesothelioma
- Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
- Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
- Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway
- Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
- Deposition of ionising energy leading to population decline via mitochondrial dysfunction
- Binding to ACE2 leading to lung fibrosis
- Interaction with lung resident cell membrane components leads to lung cancer
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
- Glutathione conjugation leading to reproductive dysfunction via oxidative stress
- ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
- Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
- Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
- Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
- Essential element imbalance leads to reproductive failure via oxidative stress
- Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
|
1497 |
Increased, recruitment of inflammatory cells |
Tissue |
Jan 3, 2018 |
May 12, 2023 |
- Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
- Frustrated phagocytosis-induced lung cancer
- Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
- Frustrated phagocytosis leads to malignant mesothelioma
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Interaction with lung resident cell membrane components leads to lung cancer
- Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
- ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
|
1031 |
Increased, release of growth factors |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
419 |
Increased, renal vitellogenin deposition |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- ER agonism leading to reduced survival due to renal failure
|
1163 |
Increased, Reproductive Success |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
- 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
|
1159 |
Increased, reuptake of 5-HT (5-hydroxytryptamine transporter; sodium-dependent serotonin transporter |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1242 |
Increased, Second Messenger Production |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Estrogen receptor activation leading to breast cancer
|
1049 |
Increased, secrection of FSH from anterior pituitary |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
|
2004 |
Increased, secretion of catecholamine |
Cellular |
Apr 22, 2022 |
Apr 22, 2022 |
|
1047 |
Increased, secretion of GnRH from hypothalamus |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
- Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
|
1048 |
Increased, secretion of leutenizing hormone |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1050 |
Increased, secretion of LH from anterior pituitary |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
- Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
|
1032 |
Increased, secretion of local growth factors |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARgamma activation leading to sarcomas in rats, mice, and hamsters
- Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
|
1496 |
Increased, secretion of proinflammatory mediators |
Cellular |
Jan 2, 2018 |
May 17, 2023 |
- Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
- Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
- Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis
- Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
- Frustrated phagocytosis leads to malignant mesothelioma
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
- Binding to ACE2 leading to lung fibrosis
- Interaction with lung resident cell membrane components leads to lung cancer
- Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
- Substance interaction with lung resident cell membrane components leading to atherosclerosis
|
1344 |
Increased, seizure |
Individual |
Apr 13, 2017 |
Jun 1, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Serotonin transporter activation to seizure
- presynaptic neuron 1 activation to epilepsy
- presynaptic neuron 2 repression to epilepsy
|
626 |
Increased, serotonin (5-HT) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
- 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
- 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
- 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
|
620 |
Increased, serotonin (5-HT) 1 1 |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
|
1397 |
Increased, serotonin transporter activity |
Cellular |
Jun 1, 2017 |
Jun 1, 2017 |
- Serotonin transporter activation to seizure
- Serotonin transporter activation to depression
- Serotonin transporter activation to agitation
|
813 |
Increased, Serum creatinine |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Kidney dysfunction by decreased thyroid hormone
|
2122 |
increased, socio-economic burden |
Population |
Apr 4, 2023 |
Feb 5, 2024 |
|
1972 |
Increased, Steroidogenic acute regulatory protein (StAR) |
Cellular |
Feb 25, 2022 |
Mar 1, 2022 |
- Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
|
2269 |
Increased, Sterol Regulatory Element Binding Protein 2 (SREBP2) protein expression |
Cellular |
Oct 22, 2024 |
Oct 22, 2024 |
- Activation, Pregnane-X receptor, NR1l2 leads to Increased, plasma low-density lipoprotein (LDL) cholesterol
|
366 |
Increased, Structural malformations |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1400 |
Increased, synaptic release |
Cellular |
Jun 1, 2017 |
Jun 1, 2017 |
- Serotonin transporter activation to seizure
- Serotonin transporter activation to depression
- Serotonin transporter activation to agitation
|
1021 |
Increased, T4/T3 catabolism |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
|
1023 |
Increased, Thyroid-stimulating hormone (TSH) |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
- Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
- Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
- Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
|
1828 |
Increased, Thyroxine (T4) in serum |
Organ |
Dec 9, 2020 |
Dec 9, 2020 |
- Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
|
881 |
Increased, Triglyceride |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- NFE2L2/FXR activation leading to hepatic steatosis
|
454 |
Increased, Triglyceride formation |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- NR1I3 (CAR) suppression leading to hepatic steatosis
- NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
|
1154 |
Increased, Triiodothyronine (T3) in tissues |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
|
1971 |
Increased, tumor growth |
Organ |
Feb 15, 2022 |
Feb 29, 2024 |
- Activation of the AhR leading to metastatic breast cancer
|
960 |
Increased, Uptake of thyroxine into tissue |
Cellular |
Nov 29, 2016 |
Dec 17, 2016 |
- Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
|
1142 |
Increased, valve movement |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
- 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
- 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
- 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
|
576 |
Increased, Viral susceptibility |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Suppression of immune system contributes to impaired development and leads to colony loss/failure
- Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
|
418 |
Increased, Vitellogenin synthesis |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- ER agonism leading to reduced survival due to renal failure
|
1166 |
Increased, water pumping |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
|
1139 |
Increased, water retention in foot |
Organ |
Nov 29, 2016 |
Dec 3, 2016 |
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
|
1919 |
Increased,Cardiac Dysregulation |
Tissue |
Aug 18, 2021 |
Sep 1, 2021 |
|
1924 |
Increased,Cardiac fibrosis |
Organ |
Aug 19, 2021 |
Sep 1, 2021 |
|
1918 |
Increased,Myocardial apoptosis |
Cellular |
Aug 18, 2021 |
Sep 1, 2021 |
|
1926 |
Increased,Vascular fibrosis |
Tissue |
Aug 19, 2021 |
Sep 1, 2021 |
|
1927 |
Increased,Vascular endothelial cell autophagy dysfunction |
Cellular |
Aug 19, 2021 |
Sep 1, 2021 |
|
1928 |
increased,Vascular endothelial dysfunction |
Tissue |
Aug 19, 2021 |
Sep 1, 2021 |
- Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway
- Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
- Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
- Demethylation of PPAR promotor leading to vascular disrupting effects
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
- Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
|
1925 |
Increased,Vascular smooth muscle cell activation |
Cellular |
Aug 19, 2021 |
Sep 1, 2021 |
|
1940 |
Increases in cellular reactive oxygen species |
Molecular |
Oct 25, 2021 |
May 10, 2022 |
- Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
|
1455 |
Incudtion, Sustained inflammatory cytokine release |
Molecular |
Jul 26, 2017 |
Jul 26, 2017 |
|
1664 |
Induce Neuronal dysfunctions |
Individual |
Jun 14, 2019 |
Jun 14, 2019 |
|
1740 |
Induced dysregulation of ACE2 |
Molecular |
Mar 10, 2020 |
Mar 3, 2022 |
- Binding to ACE2 leading to lung fibrosis
- Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
|
1257 |
Induced parturition |
Individual |
Jan 13, 2017 |
Jan 13, 2017 |
- 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
- 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
|
1255 |
induced spawning |
Individual |
Jan 13, 2017 |
Jan 13, 2017 |
- 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
|
1741 |
Induced, Angiotensin (Ang) II accumulation |
Tissue |
Mar 10, 2020 |
Mar 30, 2021 |
- ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
|
1666 |
Induced, dysfunction of microcirculation |
Organ |
Jul 3, 2019 |
Jul 3, 2019 |
- Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
- SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
|
1167 |
induced, parturition |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
|
1746 |
Induction lung fibrosis |
Organ |
Mar 10, 2020 |
Mar 10, 2020 |
|
1711 |
Induction of GATA3 expression |
Cellular |
Dec 29, 2019 |
Aug 14, 2020 |
- Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
|
1959 |
Induction of hERG trafficking defects |
Cellular |
Dec 13, 2021 |
Dec 13, 2021 |
|
1459 |
Induction, Cell damage sensing |
Molecular |
Jul 26, 2017 |
Jul 26, 2017 |
|
60 |
Induction, Chitin degradation and resorption |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
850 |
Induction, CYP1A2/CYP1A5 |
Molecular |
Nov 29, 2016 |
May 30, 2018 |
- Aryl hydrocarbon receptor activation leading to uroporphyria
- AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
|
1206 |
Induction, Doublesex1 gene |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Juvenile hormone receptor agonism leading to male offspring induction associated population decline
|
145 |
Induction, IKB inhibitory protein |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
|
164 |
Induction, Liver “Dysfunctional” Changes by CGA 330050 |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
|
1209 |
Induction, Male reproductive tract |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Juvenile hormone receptor agonism leading to male offspring induction associated population decline
|
1207 |
Induction, Male traits formation in embryos |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
838 |
Induction, Microvesicular fat |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
|
1394 |
Induction, persistent proliferation/sustained proliferation |
Cellular |
May 30, 2017 |
Jun 19, 2021 |
- Cyp2E1 Activation Leading to Liver Cancer
|
1019 |
Induction, pharyngeal muscle paralysis |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
|
238 |
Induction, Pre-mature molting |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1014 |
Induction, Somatic muscle paralysis |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
- Various neuronal effects induced by elavl3, sox10, and mbp
|
269 |
Induction, Sustained Cell Proliferation |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
|
270 |
Induction, Sustained Hepatotoxicity |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
|
295 |
Induction, Upregulation of glucuronyltransferase activity |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
- Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
- AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
|
1254 |
Infant leukaemia |
Individual |
Dec 16, 2016 |
Aug 1, 2022 |
- Inhibitor binding to topoisomerase II leading to infant leukaemia
|
901 |
Infiltration, Inflammatory cells |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Activation of reactive oxygen species leading the atherosclerosis
|
907 |
Infiltration, Inflammatory cytokines |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1599 |
Inflamatory events in light-exposed tissues |
Organ |
Feb 3, 2019 |
Jul 4, 2019 |
- Adverse outcome pathway on photochemical toxicity initiated by light exposure
- Androgen receptor activation leading to prostate cancer
|
902 |
Inflammation, Liver |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
|
2158 |
Influenza A Virus (IAV) binds sialic acid glycan receptor |
Molecular |
Jul 31, 2023 |
Aug 2, 2023 |
- Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
|
2193 |
Influenza A Virus (IAV) budding |
Cellular |
Oct 2, 2023 |
Jan 29, 2024 |
- Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
|
2159 |
Influenza A virus (IAV) cell entry |
Cellular |
Aug 11, 2023 |
Oct 3, 2023 |
- Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
|
2194 |
Influenza A Virus (IAV) shedding and transmission |
Individual |
Oct 2, 2023 |
Oct 2, 2023 |
- Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
|
2192 |
Influenza A Virus production increased |
Molecular |
Oct 2, 2023 |
Jan 29, 2024 |
- Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
|
1216 |
Influx of Ca2+, Excitation of trigeminal nerves |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1470 |
inherited mutations in offspring |
Individual |
Aug 20, 2017 |
Aug 20, 2017 |
|
1331 |
Inhibit, agitation |
Individual |
Apr 13, 2017 |
Apr 13, 2017 |
|
1332 |
Inhibit, depression |
Individual |
Apr 13, 2017 |
Apr 13, 2017 |
|
1367 |
Inhibit, gastric ulcer formation |
Organ |
Apr 17, 2017 |
Apr 17, 2017 |
|
1316 |
Inhibit, serotonin transporter activity |
Molecular |
Apr 13, 2017 |
Apr 13, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
|
2039 |
Inhibition GABAA receptor |
Molecular |
Jul 25, 2022 |
Jul 25, 2022 |
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
|
1799 |
Inhibition of 11β-HSD |
Molecular |
Jul 13, 2020 |
Jul 13, 2020 |
- Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
|
1880 |
Inhibition of ALDH1A (RALDH) |
Molecular |
May 24, 2021 |
Nov 11, 2021 |
- Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary
- Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
|
59 |
Inhibition of Apoptosis in Altered Hepatic Foci, Changes in Cellular Growth Homeostasis |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
964 |
Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
|
1660 |
Inhibition of betaine-homocysteine methyltransferase |
Molecular |
Jun 14, 2019 |
Jun 14, 2019 |
|
2023 |
Inhibition of Ceramide Synthase |
Molecular |
Jul 14, 2022 |
Jul 19, 2022 |
- Ceramide synthase inhibition leading to neural tube defects
|
1887 |
Inhibition of CYP26B1 activity |
Molecular |
May 28, 2021 |
Nov 11, 2021 |
|
1657 |
Inhibition of cystathionine beta-synthase |
Molecular |
Jun 14, 2019 |
Jun 14, 2019 |
- Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
|
1884 |
Inhibition of Fyna |
Molecular |
May 28, 2021 |
Dec 12, 2021 |
- Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
|
1960 |
Inhibition of Ikr |
Tissue |
Dec 13, 2021 |
Dec 13, 2021 |
|
1715 |
Inhibition of JAK3 |
Molecular |
Jan 5, 2020 |
Feb 15, 2021 |
- Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
|
1672 |
Inhibition of lung surfactant function |
Molecular |
Jul 3, 2019 |
Oct 27, 2021 |
- Lung surfactant function inhibition leading to decreased lung function
|
1463 |
Inhibition of lysyl oxidase |
Cellular |
Aug 3, 2017 |
Aug 3, 2017 |
- Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
|
1658 |
Inhibition of Methionine synthase |
Molecular |
Jun 14, 2019 |
Jun 14, 2019 |
|
1659 |
Inhibition of Methylenetetrahydrofolate reductase |
Molecular |
Jun 14, 2019 |
Jun 14, 2019 |
|
1481 |
Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) |
Molecular |
Oct 25, 2017 |
Oct 25, 2017 |
- Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
|
1604 |
Inhibition of N-linked glycosylation |
Molecular |
Mar 6, 2019 |
Mar 6, 2019 |
- Inhibition of N-linked glycosylation leads to liver injury
|
1429 |
Inhibition of N-type Ca ion channels |
Cellular |
Jun 23, 2017 |
Jun 23, 2017 |
- Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
- Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
|
1430 |
Inhibition of neurotransmitter vesicle release |
Cellular |
Jun 23, 2017 |
Jun 27, 2023 |
- Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
- Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
|
1885 |
Inhibition of Plxna2 |
Molecular |
May 28, 2021 |
Oct 7, 2021 |
- Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
|
2100 |
Inhibition of rapid delayed rectifying potassium current |
Cellular |
Jan 29, 2023 |
Jan 29, 2023 |
- hERG channel blockade leading to sudden cardiac death
|
2155 |
Inhibition of Sulfotransferase E1 (SULT1E1) |
Molecular |
Jul 28, 2023 |
Aug 14, 2023 |
- SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
|
2191 |
Inhibition of the Wnt/β-catenin pathway |
Cellular |
Sep 18, 2023 |
Sep 18, 2023 |
|
1627 |
Inhibition of tyrosinase |
Molecular |
May 3, 2019 |
May 3, 2019 |
- Inhibition of tyrosinase leads to decreased population in fish
|
2174 |
Inhibition VEGF/VEGFR pathway |
Cellular |
Aug 21, 2023 |
Aug 21, 2023 |
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
|
766 |
Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
|
619 |
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
- 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
- 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
- 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
- 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
|
1617 |
Inhibition, 5α-reductase |
Molecular |
Apr 18, 2019 |
Apr 5, 2024 |
- Inhibition of 5α-reductase leading to impaired fecundity in female fish
- 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring
|
790 |
Inhibition, 5α-reductase activity |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
|
1760 |
Inhibition, Activin signaling |
Cellular |
Apr 21, 2020 |
Jul 10, 2020 |
- Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
|
849 |
Inhibition, Antgonism of NE receptor |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
|
36 |
Inhibition, Aromatase |
Molecular |
Nov 29, 2016 |
Mar 14, 2022 |
- Aromatase inhibition leading to reproductive dysfunction
- Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
|
41 |
Inhibition, Bile Salt Export Pump (ABCB11) |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
|
51 |
Inhibition, Ca++ ATPase |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Calcium-mediated neuronal ROS production and energy imbalance
|
980 |
Inhibition, Calcineurin Activity |
Molecular |
Nov 29, 2016 |
Jun 27, 2021 |
- Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
|
1522 |
Inhibition, Chitin synthase 1 |
Molecular |
May 24, 2018 |
Feb 24, 2021 |
- S-adenosylmethionine depletion leading to population decline (1)
- Chitin synthase 1 inhibition leading to mortality
|
1806 |
Inhibition, Chitinase |
Molecular |
Oct 21, 2020 |
Sep 8, 2021 |
- Chitinase inhibition leading to mortality
|
1807 |
Inhibition, Chitobiase |
Molecular |
Oct 21, 2020 |
Sep 8, 2021 |
- Chitobiase inhibition leading to mortality
|
1103 |
Inhibition, Cyclooxygenase 1 activity |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
|
79 |
Inhibition, Cyclooxygenase activity |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading reproductive failure
- Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
- Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
- Cyclooxygenase inhibition leading to reproductive dysfunction
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
|
1840 |
Inhibition, cytochrome oxidase |
Molecular |
Feb 19, 2021 |
Feb 19, 2021 |
- Cytochrome oxidase inhibition leading to olfactory nasal lesions
|
1609 |
Inhibition, Cytochrome P450 enzyme (CYP17A1) activity |
Molecular |
Apr 10, 2019 |
Apr 10, 2019 |
- Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
|
1009 |
Inhibition, Deiodinase 1 |
Molecular |
Nov 29, 2016 |
Oct 10, 2022 |
- Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
- Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
|
1002 |
Inhibition, Deiodinase 2 |
Molecular |
Nov 29, 2016 |
Oct 7, 2022 |
- Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
- Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
|
1153 |
Inhibition, Deiodinase 3 |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
|
1156 |
Inhibition, Dual oxidase |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
|
2207 |
inhibition, EKR1/2 signaling pathway |
Cellular |
Jan 25, 2024 |
Jan 25, 2024 |
- Estrogen antagonism leading to increased risk of autism-like behavior
|
593 |
Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
|
1490 |
Inhibition, Fatty Acid Beta Oxidation |
Molecular |
Nov 13, 2017 |
Nov 27, 2017 |
- Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
|
2065 |
Inhibition, Fatty acid oxidation |
Cellular |
Sep 19, 2022 |
Sep 28, 2022 |
- PM2.5-related AOP frameworks on liver diseases
|
1016 |
Inhibition, Feeding |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
- Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1761 |
Inhibition, Fin regeneration |
Tissue |
Apr 21, 2020 |
Jul 10, 2020 |
- Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
|
471 |
Inhibition, FoxA2 |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
|
804 |
Inhibition, HMG-CoA reductase |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- HMG-CoA reductase inhibition leading to decreased fertility
|
1574 |
Inhibition, IKK complex |
Molecular |
Jan 7, 2019 |
Jan 7, 2019 |
- IKK complex inhibition leading to liver injury
|
147 |
Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
|
526 |
Inhibition, Inhibition of Dopamine-beta-hydroxylase |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
|
1152 |
Inhibition, Iodotyrosine deiodinase (IYD) |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
|
1308 |
Inhibition, LRH-1 |
Molecular |
Apr 12, 2017 |
Apr 12, 2017 |
|
1307 |
Inhibition, LXR |
Molecular |
Apr 12, 2017 |
Apr 12, 2017 |
|
105 |
Inhibition, Mitochondrial Electron Transport Chain Complexes |
Molecular |
Nov 29, 2016 |
Mar 22, 2023 |
- Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
- Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
- Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
- Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
|
451 |
Inhibition, Mitochondrial fatty acid beta-oxidation |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- AhR activation leading to hepatic steatosis
- NR1I3 (CAR) suppression leading to hepatic steatosis
- NFE2L2/FXR activation leading to hepatic steatosis
|
2258 |
Inhibition, monocarboxylate transporter 8 (MCT8) |
Molecular |
Aug 28, 2024 |
Aug 28, 2024 |
|
1013 |
Inhibition, Motor neuron activity |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
424 |
Inhibition, Na+/I- symporter (NIS) |
Molecular |
Nov 29, 2016 |
Apr 4, 2019 |
- XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
- Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
- Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
|
887 |
Inhibition, NADH-ubiquinone oxidoreductase (complex I) |
Cellular |
Nov 29, 2016 |
Mar 12, 2018 |
- Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
- Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
- Mitochondrial complex inhibition leading to liver injury
|
195 |
Inhibition, NMDARs |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
- Estrogen antagonism leading to increased risk of autism-like behavior
|
202 |
Inhibition, Nuclear factor kappa B (NF-kB) |
Molecular |
Nov 29, 2016 |
Mar 2, 2023 |
- Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
- IKK complex inhibition leading to liver injury
- Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
- Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
|
877 |
Inhibition, organic anion transporter 1 (OAT1) |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
|
1155 |
Inhibition, Pendrin |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Pendrin inhibition leading to altered amphibian metamorphosis
|
828 |
Inhibition, Phospholipase A |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
|
468 |
Inhibition, PPAR alpha |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NR1I3 (CAR) suppression leading to hepatic steatosis
|
798 |
Inhibition, Prolyl hydroxylases |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
- Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
|
1368 |
Inhibition, PTGS-1 (Prostaglandin-endoperoxide synthase 1) |
Molecular |
Apr 17, 2017 |
Apr 17, 2017 |
|
1371 |
Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2) |
Molecular |
Apr 17, 2017 |
Apr 17, 2017 |
|
724 |
Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
|
584 |
Inhibition, sodium channel |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Sodium channel inhibition leading to reduced survival
- sodium channel inhibition leading to increased predation
- Sodium channel inhibition leading to congenital malformations
- Sodium channel (Nav1.1) inhibition leading to population decline
|
878 |
Inhibition, SREBP1c |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NFE2L2/FXR activation leading to hepatic steatosis
|
1680 |
Inhibition, TBX1 |
Molecular |
Aug 13, 2019 |
Aug 13, 2019 |
- TBX1 inhibition leading to congenital cardiac conotruncal anomalies
|
845 |
Inhibition, UROD |
Molecular |
Nov 29, 2016 |
May 30, 2018 |
- Aryl hydrocarbon receptor activation leading to uroporphyria
|
305 |
Inhibition, VegfR2 |
Molecular |
Nov 29, 2016 |
Jan 17, 2022 |
- Disruption of VEGFR Signaling Leading to Developmental Defects
|
1294 |
Inhibition, Wnt pathway |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
|
2255 |
Innate immune response, activation |
Cellular |
Aug 13, 2024 |
Sep 13, 2024 |
- Gluten intake leading to celiac disease - under development
|
2037 |
Inositol triphosphate receptor activation |
Molecular |
Jul 25, 2022 |
Jul 25, 2022 |
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
- Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
|
298 |
Insufficiency, Vascular |
Molecular |
Nov 29, 2016 |
Jul 20, 2022 |
- Disruption of VEGFR Signaling Leading to Developmental Defects
|
2119 |
Insulin resistance, increased |
Individual |
Apr 3, 2023 |
May 26, 2023 |
- Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
- PM2.5-related AOP frameworks on liver diseases
- ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
- ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
|
1584 |
Interaction of α-diketones with arginine residues |
Molecular |
Jan 30, 2019 |
Jan 30, 2019 |
- α-diketone-induced bronchiolitis obliterans
|
979 |
Interference, nuclear localization of NFAT |
Molecular |
Nov 29, 2016 |
Jul 2, 2021 |
- Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
|
1901 |
Interferon-I antiviral response, antagonized by SARS-CoV-2 |
Cellular |
Jul 9, 2021 |
Dec 15, 2023 |
- Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
- Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption
- Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
- Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
- Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
|
1074 |
interruption, Ovulation |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
- GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
|
1931 |
Intestinal barrier, disruption |
Organ |
Sep 1, 2021 |
Jun 21, 2022 |
- Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption
- Endocytotic lysosomal uptake leads to intestinal barrier disruption
- Gluten intake leading to celiac disease - under development
|
2014 |
Intestinal epithelial cell apoptosis |
Cellular |
Jun 6, 2022 |
Jun 7, 2022 |
|
2015 |
Intestinal inflammation |
Organ |
Jun 6, 2022 |
Jun 6, 2022 |
|
405 |
irregularities, ovarian cycle |
Individual |
Nov 29, 2016 |
Nov 29, 2016 |
- Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
- Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary
- Androgen receptor (AR) antagonism leading to decreased fertility in females
|
1134 |
Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
|
1117 |
Irreversible inhibition of VKOR by binding at tyrosine 139, |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1118 |
Irreversible inhibition of VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1434 |
Irritation of nasal mucosa inducing sneeze reflex |
Tissue |
Jun 23, 2017 |
Sep 16, 2017 |
- Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
|
927 |
KE1 : S-Glutathionylation, eNOS |
Molecular |
Nov 29, 2016 |
Nov 20, 2017 |
- Peptide Oxidation Leading to Hypertension
|
935 |
KE2 : Decrease, GTPCH-1 |
Cellular |
Nov 29, 2016 |
Nov 9, 2017 |
- Peptide Oxidation Leading to Hypertension
|
934 |
KE3 : Decrease, Tetrahydrobiopterin |
Cellular |
Nov 29, 2016 |
Nov 9, 2017 |
- Peptide Oxidation Leading to Hypertension
|
932 |
KE4 : Uncoupling, eNOS |
Cellular |
Nov 29, 2016 |
Nov 9, 2017 |
- Peptide Oxidation Leading to Hypertension
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
|
973 |
KE5 : Decrease, AKT/eNOS activity |
Cellular |
Nov 29, 2016 |
Nov 9, 2017 |
- Peptide Oxidation Leading to Hypertension
|
933 |
KE6 : Depletion, Nitric Oxide |
Cellular |
Nov 29, 2016 |
Nov 9, 2017 |
- Peptide Oxidation Leading to Hypertension
|
937 |
KE7 : Impaired, Vasodilation |
Organ |
Nov 29, 2016 |
Nov 9, 2017 |
- Peptide Oxidation Leading to Hypertension
|
951 |
KE8 : Increase, Vascular Resistance |
Organ |
Nov 29, 2016 |
Nov 9, 2017 |
- Peptide Oxidation Leading to Hypertension
|
1795 |
Latent Transforming growth Factor beta expression |
Cellular |
Jul 9, 2020 |
Jul 9, 2020 |
- Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
|
1494 |
Leukocyte recruitment/activation |
Cellular |
Nov 28, 2017 |
Dec 1, 2017 |
- Endocytic lysosomal uptake leading to liver fibrosis
- Increased DNA damage leading to increased risk of breast cancer
- Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
- AhR activation leading to liver fibrosis
|
1511 |
Lipid Peroxidation |
Molecular |
Apr 4, 2018 |
Apr 4, 2018 |
- CYP2E1 activation and formation of protein adducts leading to neurodegeneration
- Activation of reactive oxygen species leading the atherosclerosis
|
1395 |
Liver Cancer |
Organ |
May 30, 2017 |
Jun 19, 2021 |
- Cyp2E1 Activation Leading to Liver Cancer
|
2034 |
liver dysfunction |
Organ |
Jul 20, 2022 |
Jul 20, 2022 |
- The AOP framwork on silica nanopariticles induced hepatoxicity
|
1549 |
Liver Injury |
Organ |
Dec 19, 2018 |
Mar 7, 2019 |
- Mitochondrial complex inhibition leading to liver injury
- IKK complex inhibition leading to liver injury
- Inhibition of N-linked glycosylation leads to liver injury
|
1389 |
Locomotor activity, decreased |
Individual |
May 2, 2017 |
May 18, 2017 |
- Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
|
2231 |
Locomotor function. Impaired |
Population |
Jun 6, 2024 |
Jun 6, 2024 |
- Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function
|
1498 |
Loss of alveolar capillary membrane integrity |
Tissue |
Jan 3, 2018 |
May 17, 2023 |
- Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
- Lung surfactant function inhibition leading to decreased lung function
|
1675 |
Loss of barrier function |
Tissue |
Jul 3, 2019 |
Jul 3, 2019 |
|
2078 |
Loss of drebrin |
Cellular |
Dec 11, 2022 |
Jul 16, 2024 |
- Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
- Various neuronal effects induced by elavl3, sox10, and mbp
|
319 |
Loss, Cochlear function |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
|
1670 |
Lung cancer |
Organ |
Jul 3, 2019 |
Aug 13, 2019 |
- Frustrated phagocytosis-induced lung cancer
- Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
- Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway
- Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway
- Interaction with lung resident cell membrane components leads to lung cancer
|
1276 |
Lung fibrosis |
Organ |
Feb 15, 2017 |
Dec 26, 2017 |
- Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
- Binding to ACE2 leading to lung fibrosis
- Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis
- Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway
- Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway
|
1246 |
Lung function, Decrease |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1540 |
lysosomal disruption EMPTY |
Molecular |
Nov 12, 2018 |
Apr 17, 2024 |
|
1616 |
Malformation, cryptorchidism - maldescended testis |
Organ |
Apr 10, 2019 |
Jul 18, 2024 |
- Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
- Androgen receptor antagonism leading to testicular cancer
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
- Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis
|
348 |
Malformation, Male reproductive tract |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARα activation in utero leading to impaired fertility in males
|
809 |
malformed, Male reproductive tract |
Individual |
Nov 29, 2016 |
Sep 16, 2017 |
- HMG-CoA reductase inhibition leading to decreased fertility
|
2234 |
Malignant transformation of cells |
Cellular |
Jun 26, 2024 |
Jun 26, 2024 |
|
1822 |
Maturation of TNF/iNOS-Producing Dendritic Cells |
Cellular |
Nov 23, 2020 |
Nov 23, 2020 |
- Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
|
1941 |
Memory Loss |
Individual |
Oct 26, 2021 |
Oct 26, 2021 |
- A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
|
2145 |
Metabolic syndrome |
Population |
May 25, 2023 |
May 25, 2023 |
- ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
|
2129 |
Metabolically unhealthy Obesity |
Individual |
Apr 5, 2023 |
Apr 5, 2023 |
- ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
|
409 |
Metabolism of AFB1, Production of Reactive Electrophiles |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
|
987 |
Metaplasia of goblet cells |
Molecular |
Nov 29, 2016 |
Oct 5, 2020 |
|
1982 |
metastatic breast cancer |
Organ |
Mar 22, 2022 |
May 14, 2024 |
- DNA damage and mutations leading to Metastatic Breast Cancer
- Activation of the AhR leading to metastatic breast cancer
|
2211 |
Microcephaly |
Organ |
Feb 2, 2024 |
Feb 2, 2024 |
|
1541 |
Mitochondrial Complex I inhibition |
Molecular |
Dec 19, 2018 |
Dec 19, 2018 |
|
1543 |
Mitochondrial Complex IV inhibition |
Molecular |
Dec 19, 2018 |
Mar 7, 2019 |
- Mitochondrial complex inhibition leading to liver injury
|
1544 |
Mitochondrial Complex V inhibition |
Molecular |
Dec 19, 2018 |
Mar 7, 2019 |
- Mitochondrial complex inhibition leading to liver injury
|
177 |
Mitochondrial dysfunction |
Cellular |
Nov 29, 2016 |
Apr 17, 2024 |
- Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
- Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
- Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
- Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
- Endocytic lysosomal uptake leading to liver fibrosis
- Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
- Estrogen receptor activation leading to breast cancer
- Mitochondrial complex inhibition leading to liver injury
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
- Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway
- Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
- Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
- AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
- Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
- Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
- Renal protein alkylation leading to kidney toxicity
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
- Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
- AOP from chemical insult to cell death
- AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
- Immune mediated hepatitis
- Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
- ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
- LXR activation leading to hepatic steatosis
- Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
- NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
- Endocytotic lysosomal uptake leads to intestinal barrier disruption
|
1816 |
Mitochondrial dysfunction EMPTY |
Cellular |
Nov 2, 2020 |
Apr 17, 2024 |
- A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
|
1547 |
Mitochondrial Injury |
Cellular |
Dec 19, 2018 |
Dec 19, 2018 |
- Mitochondrial complex inhibition leading to liver injury
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
|
1195 |
modulation, Extracellular Matrix Composition |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Estrogen receptor activation leading to breast cancer
|
598 |
modulation, sodium channel |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Axonal sodium channel modulation leading to acute mortality
|
801 |
modulation, Unknown |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
|
1912 |
Motile Cilia Number/Length, Decreased |
Cellular |
Jul 23, 2021 |
Sep 10, 2021 |
- Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
|
1425 |
Mu Opioid Receptor Agonism |
Molecular |
Jun 8, 2017 |
Jun 8, 2017 |
- Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
- Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
|
1909 |
Mucociliary Clearance, Decreased |
Individual |
Jul 19, 2021 |
Sep 10, 2021 |
- Oxidative stress Leading to Decreased Lung Function
- Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
- Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
|
1245 |
Mucus , Hypersecretion |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1244 |
Mucus hypersecretion, |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1910 |
Mucus Viscosity, Increased |
Organ |
Jul 19, 2021 |
Sep 9, 2021 |
|
1843 |
Multi Organ Failure involving Acute Respiratory Distress Syndrome |
Individual |
Mar 19, 2021 |
Nov 19, 2021 |
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
|
1934 |
Myocardial Infarction |
Organ |
Oct 15, 2021 |
Oct 15, 2021 |
- SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
|
312 |
N/A, Allergic contact dermatitis on challenge |
Individual |
Nov 29, 2016 |
Nov 29, 2016 |
|
27 |
N/A, Androgen receptor, Antagonism |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
|
764 |
N/A, Ataxia, paralysis, or hyperactivity |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Glutamate-gated chloride channel activation leading to acute mortality
|
1193 |
N/A, Breast Cancer |
Individual |
Nov 29, 2016 |
Feb 29, 2024 |
- Estrogen receptor activation leading to breast cancer
- Increased DNA damage leading to increased risk of breast cancer
- Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
|
75 |
N/A, Covalent binding to protein, possibly lysine residue |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
|
321 |
N/A, Cyanosis occurs |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Oxidation of iron in hemoglobin leading to hematotoxicity
|
119 |
N/A, Gap |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading reproductive failure
|
139 |
N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects |
Tissue |
Nov 29, 2016 |
Nov 29, 2016 |
- Sustained AhR Activation leading to Rodent Liver Tumours
|
590 |
N/A, hypoxia |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Sodium channel inhibition leading to congenital malformations
- Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
|
337 |
N/A, Impairment of reproductive capacity |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
|
158 |
N/A, Interferences with SH-/selen-proteins |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
|
344 |
N/A, Liver fibrosis |
Organ |
Nov 29, 2016 |
Dec 5, 2018 |
- Protein Alkylation leading to Liver Fibrosis
- Endocytic lysosomal uptake leading to liver fibrosis
- Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
- AhR activation leading to liver fibrosis
|
345 |
N/A, Liver Steatosis |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- LXR activation leading to hepatic steatosis
|
173 |
N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Oxidation of iron in hemoglobin leading to hematotoxicity
|
352 |
N/A, Neurodegeneration |
Tissue |
Nov 29, 2016 |
Feb 23, 2021 |
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
- Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
- Acetylcholinesterase Inhibition Leading to Neurodegeneration
- Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
- Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
- Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
- Various neuronal effects induced by elavl3, sox10, and mbp
|
213 |
N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Oxidation of iron in hemoglobin leading to hematotoxicity
|
253 |
N/A, Reproductive failure |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Cyclooxygenase inhibition leading reproductive failure
|
634 |
N/A, sedation |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Histamine (H2) receptor antagonism leading to reduced survival
|
1489 |
N/A, Steatohepatisis |
Organ |
Nov 13, 2017 |
Nov 27, 2017 |
- Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
- G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
|
294 |
N/A, Unknown |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Kidney toxicity induced by activation of 5HT2C
- Uncharacterized liver damage leading to hepatocellular carcinoma
|
1259 |
narcosis |
Cellular |
Feb 7, 2017 |
Sep 16, 2017 |
- AOP from chemical insult to cell death
|
1263 |
Necrosis |
Tissue |
Feb 7, 2017 |
Feb 7, 2017 |
- AOP from chemical insult to cell death
|
1548 |
Necrotic Tissue |
Tissue |
Dec 19, 2018 |
Mar 7, 2019 |
- Mitochondrial complex inhibition leading to liver injury
- IKK complex inhibition leading to liver injury
|
1557 |
Neural crest cell migration, reduced |
Cellular |
Dec 20, 2018 |
Dec 20, 2018 |
- Histone deacetylase inhibition leads to impeded craniofacial development
- Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
|
1561 |
Neural tube defects |
Tissue |
Dec 20, 2018 |
Dec 20, 2018 |
- Histone deacetylase inhibition leads to neural tube defects
- Ceramide synthase inhibition leading to neural tube defects
|
1514 |
Neurodegeneration |
Organ |
Apr 4, 2018 |
Apr 4, 2018 |
- CYP2E1 activation and formation of protein adducts leading to neurodegeneration
|
1436 |
neurogenic inflammation of sensory nerves |
Cellular |
Jun 27, 2017 |
Jun 27, 2017 |
|
188 |
Neuroinflammation |
Tissue |
Nov 29, 2016 |
Jul 15, 2022 |
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
- Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
- Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
- Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
- A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
- Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
- Various neuronal effects induced by elavl3, sox10, and mbp
- Binding and activation of GPER leading to learning and memory impairments
|
2150 |
Neurological disorder |
Individual |
Jun 15, 2023 |
Jun 15, 2023 |
- Increased LCN2/iron complex leading to neurological disorders
- Excessive iron accumulation leading to neurological disorders
- Various neuronal effects induced by elavl3, sox10, and mbp
|
191 |
Neuronal dysfunction |
Cellular |
Nov 29, 2016 |
Apr 7, 2022 |
- Increased LCN2/iron complex leading to neurological disorders
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1915 |
Neutrophil activation, Increased |
Cellular |
Aug 4, 2021 |
Aug 4, 2021 |
- Endothelial cell dysfunction leading to thromboinflammation
|
1417 |
NFE2/Nrf2 repression |
Molecular |
Jun 2, 2017 |
Jun 2, 2017 |
- NFE2/Nrf2 repression to steatosis
- Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway
- Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
- Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
|
1786 |
Nipple retention (NR), increased |
Individual |
May 11, 2020 |
Jan 11, 2023 |
- Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring
|
1895 |
NLRP3 inflammasome activity, increased |
Molecular |
Jun 25, 2021 |
Jun 25, 2021 |
- SARS-CoV-2 infection leading to hyperinflammation
- SARS-CoV-2 infection leading to pyroptosis
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
|
2019 |
Non-alcoholic fatty liver disease |
Individual |
Jun 27, 2022 |
Jun 27, 2022 |
- PM2.5-related AOP frameworks on liver diseases
|
2007 |
Non-coding RNA expression profile alteration |
Molecular |
May 31, 2022 |
May 31, 2022 |
- Adverse outcome pathway of PM-induced respiratory toxicity
|
1235 |
Non-neuronal production of IL-8/CXCL1, Epithelial irritation |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
|
1224 |
Non-neuronal production of TNF, Epithelial irritation |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
|
862 |
Not Increased, Circulating Ketone Bodies |
Tissue |
Nov 29, 2016 |
Apr 30, 2019 |
- Antagonist binding to PPARα leading to body-weight loss
|
1466 |
Notochord distortion or malformations |
Organ |
Aug 3, 2017 |
Aug 3, 2017 |
- Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
|
1447 |
obesity |
Individual |
Jul 24, 2017 |
Jul 24, 2017 |
- Epigenetic modification of PPARG leading to adipogenesis
|
2083 |
Occurrence of Cataracts |
Organ |
Dec 18, 2022 |
Mar 8, 2024 |
- Deposition of energy leading to occurrence of cataracts
|
2096 |
Occurrence, (Micro)vascular dysfunction |
Tissue |
Jan 23, 2023 |
Jul 31, 2023 |
- Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
|
616 |
Occurrence, A paroxysmal depolarizing shift |
Tissue |
Nov 29, 2016 |
Apr 29, 2019 |
- Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
|
2069 |
Occurrence, Abnormal Vascular Remodeling |
Organ |
Oct 17, 2022 |
Sep 17, 2024 |
- Deposition of energy leads to abnormal vascular remodeling
|
835 |
Occurrence, Ballooning degeneration (hepatocyte) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
|
2091 |
Occurrence, Bone Loss |
Organ |
Jan 11, 2023 |
Aug 23, 2024 |
- Deposition of energy leading to occurrence of bone loss
|
1106 |
Occurrence, cardiac arrhythmia |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
- Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
- unknown MIE leading to renal failure and mortality
|
1100 |
Occurrence, cardiac arrthymia |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
823 |
Occurrence, Cystic dilatation (renal tubule) |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Kidney dysfunction by decreased thyroid hormone
|
836 |
Occurrence, Cytoplasmic vacuolization (Bile duct cell) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
|
833 |
Occurrence, Cytoplasmic vacuolization (hepatocyte) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
|
837 |
Occurrence, Cytoplasmic vacuolization (kupffer cell) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
|
824 |
Occurrence, Cytoplasmic vacuolization (podocyte) |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Kidney dysfunction by decreased thyroid hormone
|
818 |
Occurrence, Cytoplasmic vacuolization (Renal tubule) |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Kidney dysfunction by decreased thyroid hormone
|
613 |
Occurrence, Epileptic seizure |
Individual |
Nov 29, 2016 |
Apr 29, 2019 |
- Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
|
1623 |
Occurrence, Focal Seizure |
Tissue |
Apr 22, 2019 |
May 20, 2020 |
- Acetylcholinesterase Inhibition Leading to Neurodegeneration
|
921 |
Occurrence, Hyperplasia of goblet cells |
Tissue |
Nov 29, 2016 |
Sep 21, 2021 |
|
814 |
Occurrence, Kidney toxicity |
Organ |
Nov 29, 2016 |
Mar 4, 2022 |
- Kidney dysfunction by decreased thyroid hormone
- Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
- Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
- Renal protein alkylation leading to kidney toxicity
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
- Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
|
920 |
Occurrence, Metaplasia of goblet cells |
Tissue |
Nov 29, 2016 |
Aug 23, 2021 |
|
1105 |
Occurrence, renal ischemia |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
|
1097 |
Occurrence, renal proximal tubular necrosis |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
- Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
- unknown MIE leading to renal failure and mortality
- Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
|
1102 |
Occurrence, tophi (urate) deposition |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
- Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
|
919 |
Occurrence, Transdifferentiation of ciliated epithelial cells |
Cellular |
Nov 29, 2016 |
Aug 17, 2021 |
|
1872 |
Olfactory epithelium degeneration |
Tissue |
Apr 25, 2021 |
Mar 30, 2022 |
- SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
|
1871 |
olfactory sensory neurons, decrease |
Cellular |
Apr 25, 2021 |
Mar 30, 2022 |
- SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
|
1218 |
Opening of calcium channel, Calcium influx |
Cellular |
Nov 29, 2016 |
Oct 25, 2017 |
- Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
|
1427 |
Opening of G protein gated inward rectifying K channels |
Cellular |
Jun 8, 2017 |
Jun 8, 2017 |
- Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
- Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
|
2187 |
Opening, voltage-gated calcium channels |
Molecular |
Sep 14, 2023 |
Sep 14, 2023 |
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
|
2042 |
Orofacial clefting |
Individual |
Jul 27, 2022 |
May 16, 2023 |
- Antagonism of Smoothened receptor leading to orofacial clefting
- Decrease, GLI1/2 target gene expression leads to orofacial clefting
- Decrease, cholesterol synthesis leads to orofacial clefting
|
1151 |
Osteoporosis and vascular calcification, Bone deterioration |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
|
601 |
Overactivation, muscle contraction |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Axonal sodium channel modulation leading to acute mortality
|
600 |
Overactivation, Neuronotransmitter release |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Axonal sodium channel modulation leading to acute mortality
|
388 |
Overactivation, NMDARs |
Cellular |
Nov 29, 2016 |
Jul 14, 2024 |
- Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
- Acetylcholinesterase Inhibition Leading to Neurodegeneration
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
- Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1886 |
Overexpression of rasl11b |
Molecular |
May 28, 2021 |
Dec 8, 2021 |
- Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
|
664 |
Overwhelmed, Mitochondrial DNA repair mechanisms |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
|
971 |
Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation |
Individual |
Nov 29, 2016 |
May 19, 2020 |
- Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
|
1596 |
Oxidation of DNA |
Cellular |
Feb 3, 2019 |
Feb 3, 2019 |
|
1594 |
Oxidation of membrane lipids |
Cellular |
Feb 3, 2019 |
Jul 4, 2019 |
- Adverse outcome pathway on photochemical toxicity initiated by light exposure
|
926 |
Oxidation, Glutathione (To be considered with MIE) |
Molecular |
Nov 29, 2016 |
Nov 9, 2017 |
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
- Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
|
844 |
Oxidation, Uroporphyrinogen |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Aryl hydrocarbon receptor activation leading to uroporphyria
|
1595 |
Oxidation/denatuation of membrane proteins |
Cellular |
Feb 3, 2019 |
Jul 4, 2019 |
- Adverse outcome pathway on photochemical toxicity initiated by light exposure
|
1520 |
Oxidative phosphorylation |
Cellular |
May 24, 2018 |
May 24, 2018 |
|
1392 |
Oxidative Stress |
Molecular |
May 30, 2017 |
Aug 26, 2024 |
- Cyp2E1 Activation Leading to Liver Cancer
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Oxidative stress Leading to Decreased Lung Function
- Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
- Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
- A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
- Adverse outcome pathway of PM-induced respiratory toxicity
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
- Deposition of energy leads to abnormal vascular remodeling
- Deposition of energy leading to occurrence of cataracts
- Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
- AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
- Deposition of energy leading to occurrence of bone loss
- Deposition of Energy Leading to Learning and Memory Impairment
- Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
- Essential element imbalance leads to reproductive failure via oxidative stress
- Calcium-mediated neuronal ROS production and energy imbalance
- Increased reactive oxygen species production leading to decreased cognitive function
- Deposition of ionizing energy leads to population decline via impaired meiosis
- Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
- Binding and activation of GPER leading to learning and memory impairments
- Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
- Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
- Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
- unknown MIE leading to renal failure and mortality
- Estrogen receptor activation leading to breast cancer
- Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
- Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
- ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
- Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
- AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway
- Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
- Demethylation of PPAR promotor leading to vascular disrupting effects
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
- Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
- CYP2E1 activation and formation of protein adducts leading to neurodegeneration
- Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
- Excessive iron accumulation leading to neurological disorders
- Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
- Various neuronal effects induced by elavl3, sox10, and mbp
- Oxidation of iron in hemoglobin leading to hematotoxicity
|
1510 |
Oxidative Stress in Brain |
Molecular |
Apr 4, 2018 |
Apr 4, 2018 |
|
1231 |
Oxidization of biomolecules, Lipid bilayer and cellular proteins |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1504 |
p21 (CDKN1A) expression, increase |
Cellular |
Jan 21, 2018 |
Nov 26, 2018 |
|
1725 |
Pancreatic acinar cell tumors |
Molecular |
Jan 8, 2020 |
Jan 8, 2020 |
- Trypsin inhibition leading to pancreatic acinar cell tumors
|
896 |
Parkinsonian motor deficits |
Individual |
Nov 29, 2016 |
Mar 12, 2018 |
- Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
- Various neuronal effects induced by elavl3, sox10, and mbp
|
209 |
Peptide Oxidation |
Molecular |
Nov 29, 2016 |
Nov 13, 2017 |
- Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
- Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
- Peptide Oxidation Leading to Hypertension
- Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
|
1947 |
Pericyte dysfunction |
Cellular |
Oct 28, 2021 |
Oct 28, 2021 |
- SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
|
2095 |
Periventricular heterotopia formation |
Individual |
Jan 19, 2023 |
Jan 19, 2023 |
- Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
|
228 |
peroxisome proliferator activated receptor promoter demethylation |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- LXR activation leading to hepatic steatosis
- NR1I3 (CAR) suppression leading to hepatic steatosis
- Epigenetic modification of PPARG leading to adipogenesis
- Demethylation of PPAR promotor leading to vascular disrupting effects
|
1086 |
persistent, cytotoxicity (pleura or peritoneum) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
|
1289 |
Perturbation of cholesterol |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
|
2182 |
Phenotype switching of vascular smooth muscle cells |
Cellular |
Sep 4, 2023 |
Sep 4, 2023 |
|
1518 |
Photosynthesis, Decrease |
Cellular |
May 24, 2018 |
May 24, 2018 |
|
1091 |
Physical and/or chemical interaction with cellular components, |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1794 |
Pin-1 activation |
Cellular |
Jul 9, 2020 |
Jul 9, 2020 |
- Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
|
1639 |
Plasma RA level decreased |
Tissue |
May 22, 2019 |
May 22, 2019 |
|
1914 |
Platelet activation, Increased |
Cellular |
Aug 4, 2021 |
Aug 4, 2021 |
- Endothelial cell dysfunction leading to thromboinflammation
|
1857 |
Platelet-neutrophil interactions, Increased |
Cellular |
Apr 8, 2021 |
Apr 8, 2021 |
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Endothelial cell dysfunction leading to thromboinflammation
|
1754 |
Porcupine-induced Wnt secretion and Wnt signaling activation |
Cellular |
Mar 23, 2020 |
Nov 25, 2022 |
- Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
|
1979 |
Premature cell differentiation |
Organ |
Mar 21, 2022 |
Mar 21, 2022 |
- Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
|
1889 |
Premature initiation of meiosis in fetal male germ cells |
Cellular |
May 29, 2021 |
Nov 11, 2021 |
- Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males
|
1146 |
premature, Spawning |
Individual |
Nov 29, 2016 |
Jan 17, 2017 |
|
1144 |
premature, spawning 1 1 |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1064 |
prepubertal increase, Estrogen receptor (ER) activity |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
|
1232 |
Production of nerve growth factor , |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1234 |
Production of nerve growth factor , Epithelial irritation |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
|
1274 |
Production of α-smooth muscle actin |
Cellular |
Feb 15, 2017 |
Feb 15, 2017 |
|
77 |
Production, Critical Metabolites (CGA 330050 and CGA 265307) |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
|
1233 |
Production, Nerve growth factor |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
249 |
Production, Reactive oxygen species |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
|
302 |
Production, VEGF-A |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
2185 |
Proliferation of vascular smooth muscle cells |
Cellular |
Sep 5, 2023 |
Sep 5, 2023 |
|
57 |
Proliferation, Cell proliferation in the absence of cytotoxicity |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Uncharacterized liver damage leading to hepatocellular carcinoma
|
1041 |
Proliferation, smooth muscle |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1067 |
Proliferation/Clonal Expansion, aberrant basal cells |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
|
1042 |
Proliferation/Clonal Expansion, smooth muscle |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
|
1961 |
Prolongation of Action Potential Duration |
Organ |
Dec 13, 2021 |
Jan 29, 2023 |
- hERG channel blockade leading to sudden cardiac death
|
1962 |
Prolongation of QT interval |
Organ |
Dec 13, 2021 |
Dec 13, 2021 |
- hERG channel blockade leading to sudden cardiac death
|
1842 |
Prolonged TLR9 activation |
Molecular |
Mar 19, 2021 |
Mar 26, 2021 |
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
|
599 |
prolonged, Depolarization of neuronal membrane |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Axonal sodium channel modulation leading to acute mortality
|
1061 |
prolonged, elevation of serun CCK |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
|
1075 |
prolonged, estrus |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
- GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
|
334 |
Promotion, Hepatocelluar carcinoma |
Individual |
Nov 29, 2016 |
Sep 16, 2017 |
- Uncharacterized liver damage leading to hepatocellular carcinoma
|
1044 |
Promotion, mesovarian leiomyomas |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
|
1053 |
Promotion, ovarian adenomas |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
- Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
|
2092 |
Promotion, Ovarian Cancer |
Organ |
Jan 12, 2023 |
Mar 11, 2023 |
- Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
|
1054 |
Promotion, ovarian granular cell tumors |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
|
1066 |
Promotion, SIX-1 postive basal-type progenitor cells |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
|
211 |
Propagation, Oxidative stress |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
|
2135 |
Prostate cancer |
Individual |
May 11, 2023 |
May 11, 2023 |
- Androgen receptor activation leading to prostate cancer
|
2136 |
prostatic intraepithelial neoplasia |
Tissue |
May 11, 2023 |
May 11, 2023 |
- Androgen receptor activation leading to prostate cancer
|
1585 |
Proteasomal dysfunction |
Molecular |
Jan 30, 2019 |
Jan 30, 2019 |
- α-diketone-induced bronchiolitis obliterans
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
|
1509 |
Protein Adduct Formation |
Molecular |
Mar 26, 2018 |
Mar 26, 2018 |
- CYP2E1 activation and formation of protein adducts leading to neurodegeneration
|
2029 |
protein-coupled estrogen receptor 1 (GPER) activation |
Molecular |
Jul 18, 2022 |
Jul 18, 2022 |
- G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
- Binding and activation of GPER leading to learning and memory impairments
|
1709 |
Psoriatic skin disease |
Individual |
Dec 27, 2019 |
Nov 23, 2020 |
- Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
|
2085 |
Pulmonary epithelial injury |
Cellular |
Jan 9, 2023 |
Jul 11, 2023 |
- AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
|
1458 |
Pulmonary fibrosis |
Organ |
Jul 26, 2017 |
May 12, 2023 |
- Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
- Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
- Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
- AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
|
1092 |
Pulmonary Fibrosis, |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
2010 |
Pulmonary inflammation |
Organ |
May 31, 2022 |
May 31, 2022 |
- Adverse outcome pathway of PM-induced respiratory toxicity
- AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
|
1967 |
Pyroptosis |
Cellular |
Jan 18, 2022 |
Jan 19, 2022 |
- SARS-CoV-2 infection leading to pyroptosis
|
1593 |
Radicals of target chemicals |
Molecular |
Feb 3, 2019 |
Feb 3, 2019 |
|
1484 |
Receptor mediated endocytosis |
Molecular |
Oct 25, 2017 |
Oct 25, 2017 |
|
1329 |
Reduce expression, BDNF (Brain-derived neurotrophic factor) |
Molecular |
Apr 13, 2017 |
May 31, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Mental stress to depression
- Mental stress to agitation
- Serotonin transporter activation to agitation
- Serotonin transporter activation to depression
|
1757 |
Reduce, Sperm count |
Individual |
Apr 6, 2020 |
Apr 6, 2020 |
- Alkylation of DNA leading to reduced sperm count
- Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males
|
2024 |
Reduced complex sphingolipids |
Cellular |
Jul 14, 2022 |
Jul 19, 2022 |
- Ceramide synthase inhibition leading to neural tube defects
|
2210 |
Reduced cortical thickness |
Tissue |
Feb 2, 2024 |
Feb 2, 2024 |
- Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
|
945 |
reduced dimerization, ARNT/HIF1-alpha |
Molecular |
Nov 29, 2016 |
Mar 23, 2018 |
- Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
- AhR activation leading to preeclampsia
|
966 |
Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
|
1135 |
Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
|
381 |
Reduced levels of BDNF |
Molecular |
Nov 29, 2016 |
Apr 4, 2019 |
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
- Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
|
2223 |
Reduced number of oligodendrocytes |
Cellular |
Apr 12, 2024 |
Apr 12, 2024 |
- Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
|
948 |
reduced production, VEGF |
Cellular |
Nov 29, 2016 |
Mar 28, 2018 |
- Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
- AhR activation leading to preeclampsia
|
1883 |
Reduced size of the ovarian reserve |
Organ |
May 24, 2021 |
Aug 6, 2024 |
- Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary
|
1677 |
Reduced tidal volume |
Organ |
Jul 3, 2019 |
Feb 16, 2021 |
- Lung surfactant function inhibition leading to decreased lung function
|
674 |
Reduced, Ability to attract spawning mates |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
- Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
|
1007 |
Reduced, Anterior swim bladder inflation |
Organ |
Nov 29, 2016 |
Oct 7, 2022 |
- Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
|
580 |
Reduced, Antiseptic incorporated in food |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
|
1335 |
Reduced, BDNF (Brain-derived neurotrophic factor) |
Molecular |
Apr 13, 2017 |
May 31, 2017 |
- Network of SSRIs (selective serotonin reuptake inhibitors)
- Mental stress to depression
- Mental stress to agitation
|
565 |
Reduced, Brood care |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
- Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
|
1424 |
Reduced, fatty acid beta oxidation |
Molecular |
Jun 2, 2017 |
Jun 2, 2017 |
- NFE2/Nrf2 repression to steatosis
|
587 |
Reduced, feeding 1 |
Individual |
Nov 29, 2016 |
Nov 29, 2016 |
- Sodium channel inhibition leading to reduced survival
- Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
|
1017 |
Reduced, Feeding 2 |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
561 |
Reduced, Food storage |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
|
1419 |
Reduced, FXR activity |
Molecular |
Jun 2, 2017 |
Jun 2, 2017 |
- NFE2/Nrf2 repression to steatosis
|
1415 |
Reduced, GABA-A receptor activation |
Molecular |
Jun 2, 2017 |
Jun 2, 2017 |
- presynaptic neuron 2 repression to epilepsy
|
689 |
Reduced, Gonadotropin releasing hormone, hypothalamus |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
|
1008 |
Reduced, Hearing |
Organ |
Nov 29, 2016 |
Feb 18, 2019 |
- GSK3beta inactivation leading to increased mortality via defects in developing inner ear
|
1423 |
Reduced, HSD17B4 activity |
Molecular |
Jun 2, 2017 |
Jun 2, 2017 |
- NFE2/Nrf2 repression to steatosis
|
690 |
Reduced, Luteinizing hormone (LH), plasma |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
|
692 |
Reduced, Maturation inducing steroid receptor signalling, oocyte |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
|
691 |
Reduced, Maturation inducing steroid, plasma |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
|
694 |
Reduced, Meiotic prophase I/metaphase I transition, oocyte |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
|
1405 |
Reduced, mucosal defense |
Tissue |
Jun 2, 2017 |
Jun 2, 2017 |
- NSAID induced PTGS1 inactivation to gastric ulcer
- Helicobacter pylori to gastric ulcer
|
1212 |
Reduced, Neuronal synaptic inhibition |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
|
678 |
Reduced, Pheromone release |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
|
1403 |
Reduced, platelet aggregation |
Tissue |
Jun 2, 2017 |
Jun 2, 2017 |
- NSAID induced PTGS1 inactivation to gastric ulcer
|
1004 |
Reduced, Posterior swim bladder inflation |
Organ |
Nov 29, 2016 |
Oct 7, 2022 |
- Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
- Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
|
1422 |
Reduced, PPARalpha |
Molecular |
Jun 2, 2017 |
Jun 2, 2017 |
- NFE2/Nrf2 repression to steatosis
|
1413 |
Reduced, presynaptic neuron 2 activity |
Cellular |
Jun 2, 2017 |
Jun 2, 2017 |
- presynaptic neuron 2 repression to epilepsy
|
383 |
Reduced, Presynaptic release of glutamate |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
|
687 |
Reduced, Prostaglandin E2 concentration, hypothalamus |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
|
671 |
Reduced, Prostaglandin F2alpha concentration, plasma |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
- Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
|
672 |
Reduced, Prostaglandin F2alpha synthesis, ovary |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
|
685 |
Reduced, Prostaglandins, ovary |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading to reproductive dysfunction
|
1402 |
Reduced, PTGS1 function |
Molecular |
Jun 2, 2017 |
Jun 2, 2017 |
- NSAID induced PTGS1 inactivation to gastric ulcer
|
1408 |
Reduced, PTGS2 function |
Cellular |
Jun 2, 2017 |
Jun 2, 2017 |
- NSAID induced PTGS2 inactivation to gastric ulcer
|
675 |
Reduced, Reproductive Success |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
- Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
- Cyclooxygenase inhibition leading to reproductive dysfunction
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
|
1420 |
Reduced, SHP activity |
Molecular |
Jun 2, 2017 |
Jun 2, 2017 |
- NFE2/Nrf2 repression to steatosis
|
673 |
Reduced, Spawning behavior |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
|
592 |
Reduced, survival |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- Sodium channel inhibition leading to reduced survival
- Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
|
1005 |
Reduced, Swimming performance |
Individual |
Nov 29, 2016 |
Sep 8, 2021 |
- Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
- Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
- Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
- Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
|
586 |
Reduced, swimming speed |
Individual |
Nov 29, 2016 |
Nov 29, 2016 |
- Sodium channel inhibition leading to reduced survival
- sodium channel inhibition leading to increased predation
- Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
|
1631 |
Reduction fo Pigmentation pattern |
Individual |
May 3, 2019 |
May 3, 2019 |
- Inhibition of tyrosinase leads to decreased population in fish
|
1626 |
reduction in melanin lead to decrease of pigmentation |
Tissue |
May 3, 2019 |
May 3, 2019 |
|
1629 |
Reduction in melanin level |
Cellular |
May 3, 2019 |
May 3, 2019 |
- Inhibition of tyrosinase leads to decreased population in fish
|
965 |
reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
- Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
|
408 |
reduction in ovarian granulosa cells, Aromatase (Cyp19a1) |
Cellular |
Nov 29, 2016 |
May 28, 2021 |
- Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
|
29 |
Reduction in, Angiogenic sprouts |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1464 |
Reduction of collagen crosslinking |
Tissue |
Aug 3, 2017 |
Aug 3, 2017 |
- Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
|
1628 |
Reduction of L-Dopaquinone |
Cellular |
May 3, 2019 |
May 3, 2019 |
- Inhibition of tyrosinase leads to decreased population in fish
|
1625 |
Reduction of L-Dopaquinone leads to melanin reduction |
Cellular |
May 3, 2019 |
May 3, 2019 |
|
1630 |
Reduction of melanosome level |
Tissue |
May 3, 2019 |
May 3, 2019 |
- Inhibition of tyrosinase leads to decreased population in fish
|
1610 |
Reduction, 17-OH-pregnenolone conversion in DHEA |
Cellular |
Apr 10, 2019 |
Apr 10, 2019 |
- Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
|
1611 |
Reduction, 17-OH-progesterone conversion in androstenedione |
Cellular |
Apr 10, 2019 |
Apr 10, 2019 |
- Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
|
3 |
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
- Aromatase inhibition leading to reproductive dysfunction
- Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
- Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
- Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
- Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
- Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
|
1789 |
Reduction, 17beta-estradiol synthesis by the undifferentiated gonad |
Cellular |
Jun 15, 2020 |
Jul 13, 2022 |
- Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
|
28 |
Reduction, Angiogenesis |
Molecular |
Nov 29, 2016 |
Jul 20, 2022 |
- Disruption of VEGFR Signaling Leading to Developmental Defects
|
49 |
Reduction, Ca and HCO3 transport to shell gland |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading reproductive failure
|
447 |
Reduction, Cholesterol transport in mitochondria |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARα activation leading to impaired fertility in adult male rodents
- PPARα activation in utero leading to impaired fertility in males
|
78 |
Reduction, Cumulative fecundity and spawning |
Individual |
Nov 29, 2016 |
Mar 20, 2017 |
- Estrogen receptor agonism leading to reproductive dysfunction
- Aromatase inhibition leading to reproductive dysfunction
- Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
- Estrogen receptor antagonism leading to reproductive dysfunction
- Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
- Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
- Inhibition of thyroid peroxidase leading to impaired fertility in fish
- Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
- Inhibition of 5α-reductase leading to impaired fecundity in female fish
- Deposition of energy leading to population decline via DNA strand breaks and follicular atresia
- Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis
- Deposition of energy leading to population decline via DNA oxidation and follicular atresia
- Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
- Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
- Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
- Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
|
1618 |
Reduction, egg production and spawning |
Individual |
Apr 18, 2019 |
Apr 18, 2019 |
|
106 |
Reduction, Eggshell thickness |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading reproductive failure
|
446 |
Reduction, fetal/adult testosterone |
Tissue |
Nov 29, 2016 |
May 17, 2023 |
- Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
|
129 |
Reduction, Gonadotropins, circulating concentrations |
Organ |
Nov 29, 2016 |
May 9, 2018 |
- Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
|
64 |
Reduction, Ionotropic GABA receptor chloride channel conductance |
Cellular |
Nov 29, 2016 |
Feb 6, 2018 |
- Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
|
669 |
Reduction, Neuronal synaptic inhibition |
Cellular |
Nov 29, 2016 |
May 16, 2018 |
- Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
|
981 |
Reduction, NFAT/AP-1 complex formation |
Cellular |
Nov 29, 2016 |
Jun 27, 2021 |
- Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
|
219 |
Reduction, Plasma 17beta-estradiol concentrations |
Organ |
Nov 29, 2016 |
Sep 26, 2017 |
- Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
- Aromatase inhibition leading to reproductive dysfunction
- Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
- Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
- Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
- Inhibition of thyroid peroxidase leading to impaired fertility in fish
- Inhibition of 5α-reductase leading to impaired fecundity in female fish
- Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
- Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
|
1693 |
Reduction, Plasma progesterone concentration |
Tissue |
Oct 3, 2019 |
Oct 3, 2019 |
- Luteinizing hormone receptor antagonism leading to reproductive dysfunction
|
221 |
Reduction, Plasma vitellogenin concentrations |
Organ |
Nov 29, 2016 |
Sep 16, 2017 |
- Aromatase inhibition leading to reproductive dysfunction
- Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
- Estrogen receptor antagonism leading to reproductive dysfunction
- Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
- Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
- Inhibition of thyroid peroxidase leading to impaired fertility in fish
- Inhibition of 5α-reductase leading to impaired fecundity in female fish
- Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
- Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
- Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
|
1692 |
Reduction, Progesterone synthesis |
Cellular |
Oct 3, 2019 |
Oct 3, 2019 |
- Luteinizing hormone receptor antagonism leading to reproductive dysfunction
|
1694 |
Reduction, progesterone uptake, decresed maturation |
Cellular |
Oct 3, 2019 |
Oct 3, 2019 |
- Luteinizing hormone receptor antagonism leading to reproductive dysfunction
|
243 |
Reduction, Prostaglandin E2 concentration |
Tissue |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading reproductive failure
|
274 |
Reduction, Testosterone synthesis by ovarian theca cells |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
|
413 |
Reduction, Testosterone synthesis in Leydig cells |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- PPARα activation leading to impaired fertility in adult male rodents
- PPARα activation in utero leading to impaired fertility in males
- Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
|
2139 |
Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma |
Organ |
May 16, 2023 |
May 16, 2023 |
- Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
|
309 |
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Aromatase inhibition leading to reproductive dysfunction
- Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
- Estrogen receptor antagonism leading to reproductive dysfunction
- Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
- Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
- Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
- Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
- Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
|
285 |
Reduction, Vitellogenin synthesis in liver |
Tissue |
Nov 29, 2016 |
May 27, 2021 |
- Aromatase inhibition leading to reproductive dysfunction
- Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
- Estrogen receptor antagonism leading to reproductive dysfunction
- Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
- Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
- Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
- Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
|
1040 |
relaxation, smooth muscle |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
|
1426 |
Release of G Proteins |
Cellular |
Jun 8, 2017 |
Jun 8, 2017 |
- Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
- Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
- Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
- Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
|
1219 |
Release of Substance P (SP), Substance P increase in circulation |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
87 |
Release, Cytokine |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
- Frustrated phagocytosis-induced lung cancer
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Endothelial cell dysfunction leading to thromboinflammation
|
2031 |
Releasing, Apoptosis-Inducing Factor (AIF) |
Molecular |
Jul 18, 2022 |
Jul 18, 2022 |
- Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway
|
985 |
Relief, Relief of atopic dermatitis |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
|
1358 |
Repress, GABA-A receptor |
Molecular |
Apr 14, 2017 |
Apr 14, 2017 |
- Molecular events lead to epilepsy
|
495 |
Repressed expression of steroidogenic enzymes |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
|
1902 |
Repression of Gbx2 expression |
Molecular |
Jul 14, 2021 |
Oct 7, 2021 |
- GSK3beta inactivation leading to increased mortality via defects in developing inner ear
|
1277 |
Reproductive failure |
Individual |
Feb 15, 2017 |
Feb 15, 2017 |
- NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
- Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
- Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
|
445 |
Respiratory distress/arrest |
Organ |
Nov 29, 2016 |
Dec 20, 2019 |
- Acetylcholinesterase inhibition leading to acute mortality
- Sodium channel inhibition leading to congenital malformations
|
397 |
Response, Keratinocytes |
Cellular |
Nov 29, 2016 |
Nov 29, 2016 |
|
1637 |
Retinaldehyde dehydrogenase inhibition |
Molecular |
May 22, 2019 |
May 22, 2019 |
- Inhibition of retinaldehyde dehydrogenase leads to population decline
|
1638 |
Retinoic acid (RA) synthesis decreased |
Cellular |
May 22, 2019 |
May 22, 2019 |
|
1278 |
ROS formation |
Molecular |
Feb 15, 2017 |
Sep 16, 2017 |
- NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
- Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway
|
1592 |
ROS generation from photoactivated chemicals |
Molecular |
Feb 3, 2019 |
Jul 4, 2019 |
- Adverse outcome pathway on photochemical toxicity initiated by light exposure
|
2186 |
Ryanodine receptor activation |
Molecular |
Sep 8, 2023 |
Sep 8, 2023 |
- Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms
|
1738 |
SARS-CoV-2 cell entry |
Cellular |
Mar 1, 2020 |
Apr 4, 2023 |
- Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
- Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
- SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
- Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)
- SARS-CoV-2 infection leading to hyperinflammation
- SARS-CoV-2 infection leading to pyroptosis
- SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
- Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption
- Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
- Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
|
1601 |
Scaling, Lichenification |
Organ |
Feb 3, 2019 |
Feb 3, 2019 |
|
2006 |
Secondary genotoxicity |
Cellular |
May 25, 2022 |
May 25, 2022 |
- Interaction with lung resident cell membrane components leads to lung cancer
|
1437 |
Sensing of the stressor by pulmonary cells |
Molecular |
Jun 29, 2017 |
Jun 29, 2017 |
|
827 |
sensitisation, skin |
Organ |
Nov 29, 2016 |
Nov 29, 2016 |
- Covalent Protein binding leading to Skin Sensitisation
|
1237 |
Sensitization, Immune system |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
|
1583 |
Sensory axonal peripheral neuropathy |
Individual |
Jan 29, 2019 |
Jan 29, 2019 |
- Microtubule interacting drugs lead to peripheral neuropathy
- Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
- Various neuronal effects induced by elavl3, sox10, and mbp
|
1431 |
Serotonin 1A Receptor Agonism |
Molecular |
Jun 23, 2017 |
Jun 23, 2017 |
- Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
- Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
|
1390 |
Sexual behavior, decreased |
Individual |
May 3, 2017 |
May 17, 2017 |
- Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
|
1904 |
six1b expression, increased |
Molecular |
Jul 14, 2021 |
Aug 12, 2021 |
- GSK3beta inactivation leading to increased mortality via defects in developing inner ear
|
417 |
skewed, sex ratio |
Population |
Nov 29, 2016 |
Dec 3, 2016 |
- ER agonism leading to skewed sex ratios due to altered sexual differentiation in males
|
1649 |
Snail, Zeb, Twist activation |
Molecular |
May 29, 2019 |
May 29, 2019 |
|
1222 |
SP (Substance P) release, Local increase of SP |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
|
1515 |
Spermatocyte depletion |
Tissue |
May 2, 2018 |
Jul 28, 2021 |
- Histone deacetylase inhibition leading to testicular atrophy
|
1068 |
squamous metaplasia, aberrant basal cells |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
|
999 |
stabilization, co-repressor |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1000 |
stabilization, PPAR alpha co-repressor |
Molecular |
Nov 29, 2016 |
Apr 30, 2019 |
- Antagonist binding to PPARα leading to body-weight loss
|
1788 |
Status epilepticus |
Individual |
May 21, 2020 |
May 21, 2020 |
- Acetylcholinesterase Inhibition Leading to Neurodegeneration
|
650 |
Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
|
1706 |
Stimulation, TLR7/8 |
Molecular |
Dec 27, 2019 |
Nov 21, 2020 |
- Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
|
2226 |
Stressor binding PPAR isoforms |
Molecular |
May 8, 2024 |
May 22, 2024 |
- Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
|
1671 |
Substance - lung surfactant interaction |
Molecular |
Jul 3, 2019 |
Jul 3, 2019 |
|
1495 |
Substance interaction with the lung resident cell membrane components |
Molecular |
Jan 2, 2018 |
May 17, 2023 |
- Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
- Interaction with lung resident cell membrane components leads to lung cancer
- Substance interaction with lung resident cell membrane components leading to atherosclerosis
|
2243 |
Succinate Accumulation |
Cellular |
Jul 18, 2024 |
Jul 18, 2024 |
- Succinate dehydrogenase inactivation leads to cancer by promoting EMT
- Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
|
2118 |
Succinate dehydrogenase, inhibited |
Molecular |
Apr 3, 2023 |
May 4, 2023 |
- Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
- Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress
- Succinate dehydrogenase inactivation leads to cancer by promoting EMT
- Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
|
1964 |
Sudden cardiac death |
Individual |
Dec 13, 2021 |
Dec 13, 2021 |
- hERG channel blockade leading to sudden cardiac death
|
2120 |
Superoxide generation, increased |
Cellular |
Apr 3, 2023 |
Apr 17, 2023 |
- Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
|
1565 |
Suppressed AP-1 |
Cellular |
Dec 24, 2018 |
Dec 24, 2018 |
|
1567 |
Suppressed DC activation |
Organ |
Dec 24, 2018 |
Dec 24, 2018 |
|
1573 |
Suppressed MyD88 |
Cellular |
Jan 6, 2019 |
Mar 17, 2019 |
|
1566 |
Suppressed NF-kB |
Cellular |
Dec 24, 2018 |
Dec 24, 2018 |
|
1701 |
Suppression of NF-kB |
Molecular |
Nov 17, 2019 |
Nov 17, 2019 |
|
1702 |
Suppression of T cell activation |
Cellular |
Nov 17, 2019 |
Mar 6, 2023 |
- Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
|
1718 |
Suppression of IL-4 production |
Cellular |
Jan 5, 2020 |
Feb 24, 2021 |
- Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
|
1717 |
Suppression of STAT5 binding to cytokine gene promoters |
Cellular |
Jan 5, 2020 |
Feb 24, 2021 |
- Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
|
456 |
Suppression, Constitutive androstane receptor, NR1l3 |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NR1I3 (CAR) suppression leading to hepatic steatosis
|
1046 |
Suppression, Estrogen receptor (ER) activity |
Molecular |
Nov 29, 2016 |
Feb 28, 2022 |
- Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
- Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
|
461 |
Suppression, HNF4alpha |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- HNF4alpha suppression leading to hepatic steatosis
|
1202 |
Suppression, IL-2 and IL-4 production |
Cellular |
Nov 29, 2016 |
Jun 27, 2021 |
- Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
|
403 |
Suppression, Immune system |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
- Suppression of immune system contributes to impaired development and leads to colony loss/failure
- Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
- Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
|
152 |
Suppression, Inflammatory cytokines |
Individual |
Nov 29, 2016 |
Dec 3, 2016 |
- Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
|
982 |
Suppression, Suppression in mixed lymphocyte reaction (MLR) |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
|
1203 |
Suppression, Suppression of production of cytotoxic T-cells |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
|
1204 |
Suppression, Suppression of T-cell dependent antibody production |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
|
983 |
Suppression, Suppression of T-cell dependent antibody response (TDAR) |
Cellular |
Nov 29, 2016 |
Dec 3, 2016 |
|
450 |
Suppression, VLDL secretion |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
- AhR activation leading to hepatic steatosis
|
1870 |
Sustentacular cells, decrease |
Cellular |
Apr 25, 2021 |
Mar 30, 2022 |
- SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
|
1944 |
Synaptic dysfunction |
Organ |
Oct 26, 2021 |
Jan 4, 2023 |
- A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
- Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
- Various neuronal effects induced by elavl3, sox10, and mbp
|
89 |
Synthesis, De Novo Fatty Acid (FA) |
Cellular |
Nov 29, 2016 |
Mar 29, 2024 |
- LXR activation leading to hepatic steatosis
- Liver X Receptor (LXR) activation leads to liver steatosis
|
1439 |
Systemic acute phase response |
Organ |
Jun 29, 2017 |
Dec 18, 2023 |
- Substance interaction with lung resident cell membrane components leading to atherosclerosis
|
486 |
systemic inflammation leading to hepatic steatosis |
Organ |
Nov 29, 2016 |
Feb 24, 2017 |
- AKT2 activation leading to hepatic steatosis
|
1844 |
systemic inflammatory response syndrome |
Individual |
Mar 19, 2021 |
Mar 19, 2021 |
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation
|
1589 |
Systemic or topical administration of chemicals |
Molecular |
Feb 3, 2019 |
Feb 3, 2019 |
|
1506 |
Testicular atrophy |
Organ |
Jan 21, 2018 |
Jul 1, 2021 |
- Histone deacetylase inhibition leading to testicular atrophy
|
1839 |
Testicular Cancer |
Organ |
Feb 12, 2021 |
Feb 12, 2021 |
- Androgen receptor antagonism leading to testicular cancer
|
1704 |
testJF |
Molecular |
Dec 5, 2019 |
Dec 5, 2019 |
|
2272 |
Testosterone levels, increased |
Tissue |
Nov 2, 2024 |
Nov 2, 2024 |
|
1708 |
Th17 cell migration and inflammation induction |
Cellular |
Dec 27, 2019 |
Nov 23, 2020 |
- Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
|
974 |
The binding of FK506 with FKBP12, |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
975 |
The binding of FK506 with FKBP12, The binding of FK506 with FKBP12 |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
2240 |
The NO synthase pathway activation |
Cellular |
Jul 9, 2024 |
Jul 9, 2024 |
- Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
|
1462 |
Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts |
Molecular |
Aug 3, 2017 |
Aug 3, 2017 |
- Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
|
1916 |
Thromboinflammation, Increased |
Organ |
Aug 4, 2021 |
Aug 4, 2021 |
- Endothelial cell dysfunction leading to thromboinflammation
|
1846 |
Thrombosis and Disseminated Intravascular Coagulation |
Individual |
Mar 25, 2021 |
Nov 25, 2022 |
- Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
- Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
|
277 |
Thyroid hormone synthesis, Decreased |
Cellular |
Nov 29, 2016 |
Nov 4, 2022 |
- Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Kidney dysfunction by decreased thyroid hormone
- Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
- Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Thyroperoxidase inhibition leading to altered amphibian metamorphosis
- Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
- Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
- Pendrin inhibition leading to altered amphibian metamorphosis
- Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
- Inhibition of thyroid peroxidase leading to impaired fertility in fish
- Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
- Thyroperoxidase inhibition leading to altered visual function via decreased eye size
- Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
- Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
- Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
- Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
- Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
- AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
|
279 |
Thyroperoxidase, Inhibition |
Molecular |
Nov 29, 2016 |
Nov 4, 2022 |
- Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
- Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
- Thyroperoxidase inhibition leading to altered amphibian metamorphosis
- Inhibition of thyroid peroxidase leading to impaired fertility in fish
- Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
- Thyroperoxidase inhibition leading to altered visual function via decreased eye size
- Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
- Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
|
280 |
Thyroxine (T4) in neuronal tissue, Decreased |
Organ |
Nov 29, 2016 |
Apr 4, 2019 |
- Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
- Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
- AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
- AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
|
1492 |
Tissue resident cell activation |
Cellular |
Nov 28, 2017 |
Jul 26, 2024 |
- Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
- Protein Alkylation leading to Liver Fibrosis
- Increased DNA damage leading to increased risk of breast cancer
- Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
- Deposition of Energy Leading to Learning and Memory Impairment
|
1848 |
Toll Like Receptor (TLR) Dysregulation |
Molecular |
Mar 26, 2021 |
Nov 23, 2021 |
- Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
- Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load
- Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
|
1792 |
Toll-like receptor 4 activation |
Molecular |
Jul 9, 2020 |
Jul 9, 2020 |
- Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
|
1963 |
Torsades de Pointes |
Organ |
Dec 13, 2021 |
Jan 29, 2023 |
- hERG channel blockade leading to sudden cardiac death
|
1438 |
Transcription of genes encoding acute phase proteins, Increased |
Organ |
Jun 29, 2017 |
Dec 18, 2023 |
- Substance interaction with lung resident cell membrane components leading to atherosclerosis
|
1970 |
transposition of the great arteries |
Organ |
Feb 8, 2022 |
Feb 15, 2022 |
- Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
|
1354 |
Treat, carbamazepine |
Molecular |
Apr 14, 2017 |
Apr 14, 2017 |
- Molecular events lead to epilepsy
- presynaptic neuron 1 activation to epilepsy
|
1651 |
Treatment-resistant gastric cancer |
Tissue |
May 29, 2019 |
Oct 13, 2022 |
- Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
|
1223 |
Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea |
Tissue |
Nov 29, 2016 |
Sep 24, 2018 |
- Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
|
1220 |
Trigeminal nerve activation |
Tissue |
Nov 29, 2016 |
Sep 24, 2018 |
- Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
|
1229 |
TRPA1 activation, Chemical covalent binding to sulfhydyl group on TRPA1 receptor protein/ HEK293 fibroblast cells |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1227 |
TRPA1 activation, Chemical covalent binding to sulfhydyl group on TRPA1 receptor protein/NEK293 fibroblast cells |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1228 |
TRPA1 activation, Classic receptor binding / HEK 293 cells (fibroclast), cho cells (ovary), noncovalently linkked) |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1215 |
TRPA1 activation, TRPA1 Receptor |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
|
1230 |
TRPV1 activation, TRPV1 |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
|
1720 |
Trypsin inhibition |
Molecular |
Jan 8, 2020 |
Jan 8, 2020 |
- Trypsin inhibition leading to pancreatic acinar cell tumors
|
378 |
Tumorigenesis, Hepatocellular carcinoma |
Individual |
Nov 29, 2016 |
Nov 29, 2016 |
- AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
|
1624 |
Tyrosinase inhibition leads to L-Dopaquinone reduction |
Molecular |
May 3, 2019 |
May 3, 2019 |
|
1150 |
Uncarboxylated osteocalcin not incorporated into bone matrix, decreasing bone strength, Impaired function of osteocalcin and MGP |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1138 |
Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
|
1120 |
Under carboxylated clotting factors will not assemble on cell surfaces , Failure to form clot |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1122 |
Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis |
Tissue |
Nov 29, 2016 |
Dec 3, 2016 |
- Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
|
1137 |
Under carboxylation of osteocalcin, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1168 |
Undercarboxylation of osteocalcin , Affects bone formation (osteoblast-osteoclast interaction, bone resorption) and glucose and lipid hoemostasis |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1512 |
Unfolded Protein Response |
Molecular |
Apr 4, 2018 |
Sep 14, 2023 |
- CYP2E1 activation and formation of protein adducts leading to neurodegeneration
- Inhibition of N-linked glycosylation leads to liver injury
- Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
|
1113 |
Unknown, |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1114 |
Unknown, MIE |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
- unknown MIE leading to renal failure and mortality
- Unknown MIE altering cholesterol metabolism leading to decreased cognition
|
1129 |
Unresolved blood loss (hemorrhage), Failure in vascular repair mechanisms |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1126 |
Unresolved blood loss, Failure in vascular repair mechanisms |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1128 |
Unresolved hemorrhage, Failure in vascular repair mechanisms |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
470 |
Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NR1I3 (CAR) suppression leading to hepatic steatosis
|
54 |
Up Regulation, CD36 |
Molecular |
Nov 29, 2016 |
Mar 26, 2024 |
- LXR activation leading to hepatic steatosis
- NR1I3 (CAR) suppression leading to hepatic steatosis
- AhR activation leading to hepatic steatosis
- NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
- Pregnane X Receptor (PXR) activation leads to liver steatosis
|
80 |
Up Regulation, CYP1A1 |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- AhR activation leading to hepatic steatosis
- AhR activation leading to liver fibrosis
|
84 |
Up Regulation, CYP1B1 |
Molecular |
Nov 29, 2016 |
Dec 3, 2016 |
|
463 |
Up Regulation, FAS |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NR1I3 (CAR) suppression leading to hepatic steatosis
|
466 |
Up Regulation, LDLR (low density lipoprotein receptor) |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- AhR activation leading to hepatic steatosis
|
462 |
Up Regulation, SCD-1 |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- NR1I3 (CAR) suppression leading to hepatic steatosis
- NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
- AhR activation leading to hepatic steatosis
- G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
|
1284 |
Up Regulation, SREBF2 |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
- G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
|
276 |
Up Regulation, TGFbeta1 expression |
Cellular |
Nov 29, 2016 |
Sep 16, 2017 |
|
1285 |
Up Regulation, Unsaturated fatty acid |
Cellular |
Feb 15, 2017 |
Sep 16, 2017 |
- Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
|
695 |
Upregulated, Spindle assembly checkpoint protein Mad2-oocyte |
Molecular |
Nov 29, 2016 |
Sep 16, 2017 |
- Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
|
369 |
Uroporphyria |
Individual |
Nov 29, 2016 |
May 7, 2018 |
- Aryl hydrocarbon receptor activation leading to uroporphyria
|
1762 |
Urothelial cell injury/death |
Cellular |
Apr 21, 2020 |
Apr 21, 2020 |
- AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
|
1763 |
Urothelial Tumor |
Organ |
Apr 21, 2020 |
Apr 21, 2020 |
- AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
|
2154 |
Uterine adenocarcinoma (endometrioid adenocarcinoma Type I) |
Organ |
Jul 27, 2023 |
Jul 27, 2023 |
- Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
|
2178 |
Vascular barrier disruption |
Tissue |
Aug 21, 2023 |
Aug 21, 2023 |
- The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
|
2000 |
Vascular calcification |
Organ |
Apr 21, 2022 |
Apr 21, 2022 |
|
2003 |
Vascular remodeling |
Organ |
Apr 22, 2022 |
Apr 22, 2022 |
|
2002 |
Ventricular remodeling |
Organ |
Apr 22, 2022 |
Apr 22, 2022 |
|
2032 |
Viable offspring, decreased |
Individual |
Jul 18, 2022 |
Jul 18, 2022 |
|
1939 |
Viral infection and host-to-host transmission, proliferated |
Individual |
Oct 24, 2021 |
Jun 29, 2024 |
- Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
|
1165 |
Vitamin K inhibition, gamma-carboxylation of glutamate to Gla residues reduced in bone proteins e.g., periostin |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1111 |
weaj, |
|
Nov 29, 2016 |
Nov 29, 2016 |
|
1465 |
Weak collagen matrix |
Tissue |
Aug 3, 2017 |
Aug 3, 2017 |
- Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
|
2062 |
Weak, Procuticle protection |
Organ |
Aug 28, 2022 |
Aug 28, 2022 |
- Knickkopf leading to mortality
|
1107 |
Weakened, Colony |
Population |
Nov 29, 2016 |
Jun 7, 2018 |
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
- Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
- Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
- Varroa mite infestation increases virus levels leading to colony loss/failure
- Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure
- Weather event contributes to colony loss/failure
- Weather event contributes abnormal foraging leading to colony loss/failure
- Nosema infection increases energetic demands leading to colony loss/failure
- Nosema infection causes abnormal role change that leads to colony loss/failure
- Queen egg-laying decrease leads to colony loss/failure
|
1645 |
Wnt ligand stimulation |
Molecular |
May 28, 2019 |
May 29, 2019 |
|
1648 |
β-catenin activation |
Molecular |
May 29, 2019 |
May 29, 2019 |
|