API XML

Aop: 346

AOP Title

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Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation

Short name:

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Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Kelvin Santana Rodriguez   (email point of contact)

Contributors

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  • Kelvin Santana Rodriguez

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on July 28, 2020 21:52

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Revision dates for related pages

Page Revision Date/Time
Inhibition, Aromatase September 16, 2017 10:14
Reduction, 17beta-estradiol synthesis by the undifferentiated gonad September 15, 2020 13:49
Increased, Differentiation to Testis September 15, 2020 14:01
Increased, Male Biased Sex Ratio August 07, 2020 18:17
Decrease, Population trajectory September 26, 2017 11:33
Inhibition, Aromatase leads to Reduction, E2 Synthesis by the undifferentiated gonad June 15, 2020 09:50
Reduction, E2 Synthesis by the undifferentiated gonad leads to Increased, Differentiation to Testis September 17, 2020 09:02
Inhibition, Aromatase leads to Increased, Differentiation to Testis July 28, 2020 21:49
Increased, Differentiation to Testis leads to Increased, Male Biased Sex Ratio September 17, 2020 09:03
Increased, Male Biased Sex Ratio leads to Decrease, Population trajectory September 17, 2020 06:34

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 36 Inhibition, Aromatase Inhibition, Aromatase
KE 1789 Reduction, 17beta-estradiol synthesis by the undifferentiated gonad Reduction, E2 Synthesis by the undifferentiated gonad
KE 1790 Increased, Differentiation to Testis Increased, Differentiation to Testis
KE 1791 Increased, Male Biased Sex Ratio Increased, Male Biased Sex Ratio
AO 360 Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Inhibition, Aromatase leads to Reduction, E2 Synthesis by the undifferentiated gonad adjacent
Reduction, E2 Synthesis by the undifferentiated gonad leads to Increased, Differentiation to Testis adjacent
Inhibition, Aromatase leads to Increased, Differentiation to Testis adjacent
Increased, Differentiation to Testis leads to Increased, Male Biased Sex Ratio adjacent
Increased, Male Biased Sex Ratio leads to Decrease, Population trajectory adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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