API

Event: 360

Key Event Title

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Decrease, Population trajectory

Short name

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Decrease, Population trajectory

Biological Context

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Level of Biological Organization
Population



Key Event Components

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Process Object Action
population growth rate population of organisms decreased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Androgen receptor agonism leading to reproductive dysfunction AdverseOutcome
Aromatase inhibition leading to reproductive dysfunction AdverseOutcome
Estrogen receptor agonism leading to reproductive dysfunction AdverseOutcome
Estrogen receptor antagonism leading to reproductive dysfunction AdverseOutcome
Cyclooxygenase inhibition 2 AdverseOutcome
Prolyl hydroxylase inhibition AdverseOutcome
Unknown MIE leading to reprodl AdverseOutcome
DIO2i posterior swim bladder AdverseOutcome
DIO2i anterior swim bladder AdverseOutcome
DIO1i posterior swim bladder AdverseOutcome
DIO1i anterior swim bladder AdverseOutcome
TPOi anterior swim bladder AdverseOutcome
Cyclooxygenase inhibition 3 AdverseOutcome
Cyclooxygenase inhibition 4 AdverseOutcome
Cyclooxygenase inhibition 1 AdverseOutcome
Cyclooxygenase inhibition 5 AdverseOutcome
ATP synthase inhibition leading to growth arrest (1) AdverseOutcome
ATP synthase inhibition leading to growth arrest (2) AdverseOutcome
tyrosinase, fish AdverseOutcome
AHR mediated epigenetic reproductive failure AdverseOutcome
AChE inhibition - acute mortality AdverseOutcome
AChE inhibition - acute mortality via predation AdverseOutcome
GR Agonism Leading to Impaired Fin Regeneration AdverseOutcome
DNMT inhibtion leading to population decline (1) AdverseOutcome
DNMT inhibtion leading to population decline (2) AdverseOutcome
DNMT inhibtion leading to population decline (3) AdverseOutcome
DNMT inhibtion leading to population decline (4) AdverseOutcome
DNMT inhibtion leading to transgenerational effects (1) AdverseOutcome
DNMT inhibtion leading to transgenerational effects (2) AdverseOutcome
5α-reductase,female fish AdverseOutcome
retinaldehyde dehydrogenase inhibition,population decline AdverseOutcome
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation AdverseOutcome
ROS production leading to population decline via reduced FAO AdverseOutcome
ROS production leading to population decline via mitochondrial dysfunction AdverseOutcome
ROS production leading to population decline via follicular atresia AdverseOutcome
ROS production leading to population decline via LPO AdverseOutcome

Stressors

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Taxonomic Applicability

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Term Scientific Term Evidence Link
all species all species High NCBI

Life Stages

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Life stage Evidence
All life stages Not Specified

Sex Applicability

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Term Evidence
Unspecific Not Specified

Key Event Description

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Maintenance of sustainable fish and wildlife populations (i.e., adequate to ensure long-term delivery of valued ecosystem services) is an accepted regulatory goal upon which risk assessments and risk management decisions are based.


How It Is Measured or Detected

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Population trajectories, either hypothetical or site specific, can be estimated via population modeling based on measurements of vital rates or reasonable surrogates measured in laboratory studies. As an example, Miller and Ankley 2004 used measures of cumulative fecundity from laboratory studies with repeat spawning fish species to predict population-level consequences of continuous exposure.


Domain of Applicability

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Consideration of population size and changes in population size over time is potentially relevant to all living organisms.


Regulatory Significance of the Adverse Outcome

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Maintenance of sustainable fish and wildlife populations (i.e., adequate to ensure long-term delivery of valued ecosystem services) is a widely accepted regulatory goal upon which risk assessments and risk management decisions are based.


References

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  • Miller DH, Ankley GT. 2004. Modeling impacts on populations: fathead minnow (Pimephales promelas) exposure to the endocrine disruptor 17ß-trenbolone as a case study. Ecotoxicology and Environmental Safety 59: 1-9.