API XML

Aop: 338

AOP Title

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DNA methyltransferase inhibition leading to population decline (#3)

Short name:

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DNMT inhibtion leading to population decline (#3)

Graphical Representation

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Click to download graphical representation template

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Authors

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Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under Development: Contributions and Comments Welcome


This AOP was last modified on May 01, 2020 02:11

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Revision dates for related pages

Page Revision Date/Time
Increase, DNA methyltransferase inhibition April 22, 2019 05:09
Increase, DNA double-strand break April 30, 2020 12:28
Increase, Caspase transcription April 30, 2020 16:40
Increase, Oocyte apoptosis April 30, 2020 16:41
Decrease, Oogenesis April 30, 2020 16:41
Decrease, Fecundity June 12, 2018 04:39
Decrease, Population trajectory September 26, 2017 11:33
Increase, DNMT inhibition leads to Increase, DNA DSB April 30, 2020 17:28
Increase, DNA DSB leads to Increase, Casp transcription April 30, 2020 17:29
Increase, Casp transcription leads to Increase, Oocyte apoptosis April 30, 2020 16:43
Increase, Oocyte apoptosis leads to Decrease, Oogenesis April 30, 2020 16:44
Decrease, Oogenesis leads to Decrease, Fecundity June 12, 2018 04:41
Decrease, Fecundity leads to Decrease, Population trajectory April 22, 2019 05:00
5-Azacytidine April 22, 2019 05:01

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1619 Increase, DNA methyltransferase inhibition Increase, DNMT inhibition
KE 1766 Increase, DNA double-strand break Increase, DNA DSB
KE 1774 Increase, Caspase transcription Increase, Casp transcription
KE 1775 Increase, Oocyte apoptosis Increase, Oocyte apoptosis
KE 1366 Decrease, Oogenesis Decrease, Oogenesis
AO 328 Decrease, Fecundity Decrease, Fecundity
AO 360 Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, DNMT inhibition leads to Increase, DNA DSB adjacent High Low
Increase, DNA DSB leads to Increase, Casp transcription adjacent Moderate Low
Increase, Casp transcription leads to Increase, Oocyte apoptosis adjacent Moderate Low
Increase, Oocyte apoptosis leads to Decrease, Oogenesis adjacent Moderate Low
Decrease, Oogenesis leads to Decrease, Fecundity adjacent Moderate Low
Decrease, Fecundity leads to Decrease, Population trajectory adjacent Moderate Low

Network View

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Stressors

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Name Evidence Term
5-Azacytidine High

Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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