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Use the greater than or less than comparison operators (>,=>,<,or =<) to filter Key Events by Creation Date or Last Upated properties.
Use the greater than or less than comparison operators (>,=>,<,or =<) to filter Key Events by Creation Date or Last Upated properties.
KE Relationships
ID | Upstream Event | Downstream Event | Creation Date | Last Updated | AOPs |
---|---|---|---|---|---|
3326 | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | Reduction, Vitellogenin synthesis in liver | Jul 26, 2024 | Jul 26, 2024 |
|
5 | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | Reduction, Plasma 17beta-estradiol concentrations | Nov 29, 2016 | Mar 20, 2017 |
|
9 | Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity | Decreased, Mitochondrial fatty acid beta-oxidation | Nov 29, 2016 | Dec 3, 2016 |
|
750 | Activation, 5HT2c | N/A, Unknown | Nov 29, 2016 | Dec 3, 2016 |
|
454 | ACh Synaptic Accumulation | Increased, Atrioventricular block and bradycardia | Nov 29, 2016 | Nov 29, 2016 | |
456 | ACh Synaptic Accumulation | Increased Cholinergic Signaling | Nov 29, 2016 | Dec 20, 2019 |
|
459 | ACh Synaptic Accumulation | AchE Inhibition | Nov 29, 2016 | Dec 3, 2016 |
|
1857 | ACh Synaptic Accumulation | Activation, Muscarinic Acetylcholine Receptors | Feb 13, 2019 | Sep 3, 2023 |
|
452 | AchE Inhibition | Increased Mortality | Nov 29, 2016 | Dec 20, 2019 |
|
453 | AchE Inhibition | Decreased, Population trajectory | Nov 29, 2016 | Dec 20, 2019 | |
11 | AchE Inhibition | ACh Synaptic Accumulation | Nov 29, 2016 | Sep 10, 2023 |
|
449 | AchE Inhibition | Increased, Atrioventricular block and bradycardia | Nov 29, 2016 | Dec 3, 2016 | |
450 | AchE Inhibition | Respiratory distress/arrest | Nov 29, 2016 | Dec 20, 2019 |
|
451 | AchE Inhibition | Increased Cholinergic Signaling | Nov 29, 2016 | Dec 20, 2019 |
|
2653 | AchE Inhibition | Activation of Cyp2E1 | May 16, 2022 | May 16, 2022 |
|
3430 | AchE Inhibition | Activation, Muscarinic Acetylcholine Receptors | Nov 22, 2024 | Nov 22, 2024 |
|
3063 | AchE Inhibition | Increase, CNS Neural cell death | Oct 17, 2023 | Oct 17, 2023 |
|
3064 | AchE Inhibition | Dysfunctional synapses | Oct 17, 2023 | Oct 17, 2023 |
|
2014 | AchE Inhibition | Impaired coordination and movement | Dec 20, 2019 | Dec 20, 2019 |
|
2016 | AchE Inhibition | Decrease, Population growth rate | Dec 20, 2019 | Dec 20, 2019 |
|
2007 | AchE Inhibition | Cardiovascular dysregulation | Nov 25, 2019 | Dec 20, 2019 |
|
16 | Altered expression of AHR/ARNT pathway-dependent genes | Altered, Cardiovascular development/function | Nov 29, 2016 | Dec 3, 2016 | |
17 | Altered expression of AHR/ARNT pathway-dependent genes | Up Regulation, CYP1A1 | Nov 29, 2016 | Dec 3, 2016 | |
18 | Activation, AhR | Altered expression of AHR/ARNT pathway-dependent genes | Nov 29, 2016 | Dec 3, 2016 | |
19 | Activation, AhR | Up Regulation, CYP1A1 | Nov 29, 2016 | Dec 3, 2016 |
|
1992 | Activation, AhR | Increase, DNMT expression | Oct 30, 2019 | Oct 30, 2019 | |
473 | Activation, AhR | Inhibition, Mitochondrial fatty acid beta-oxidation | Nov 29, 2016 | Dec 3, 2016 |
|
495 | Activation, AhR | Up Regulation, CD36 | Nov 29, 2016 | Dec 3, 2016 |
|
496 | Activation, AhR | Increased, FA Influx | Nov 29, 2016 | Dec 3, 2016 | |
499 | Activation, AhR | Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) | Nov 29, 2016 | Dec 3, 2016 |
|
506 | Activation, AhR | Up Regulation, LDLR (low density lipoprotein receptor) | Nov 29, 2016 | Dec 3, 2016 |
|
509 | Activation, AhR | Suppression, VLDL secretion | Nov 29, 2016 | Dec 3, 2016 |
|
984 | Activation, AhR | Increase, Early Life Stage Mortality | Nov 29, 2016 | Apr 14, 2019 |
|
869 | Activation, AhR | Induction, CYP1A2/CYP1A5 | Nov 29, 2016 | May 7, 2018 |
|
972 | Activation, AhR | dimerization, AHR/ARNT | Nov 29, 2016 | Mar 22, 2018 |
|
3219 | Activation, AhR | Increased, Liver Steatosis | May 14, 2024 | May 14, 2024 |
|
2888 | Activation, AhR | N/A, Liver Steatosis | Apr 13, 2023 | Apr 13, 2023 | |
2883 | Activation, AhR | Induction, Upregulation of glucuronyltransferase activity | Apr 12, 2023 | Apr 12, 2023 |
|
2687 | Activation, AhR | Increase, slincR expression | Jun 30, 2022 | Jun 30, 2022 | |
2688 | Activation, AhR | Decrease, sox9 expression | Jun 30, 2022 | Apr 13, 2023 |
|
2689 | Activation, AhR | Smaller and morphologically distorted facial cartilage structures | Jun 30, 2022 | Apr 13, 2023 |
|
2765 | Activation, AhR | Altered, Cardiovascular development/function | Sep 27, 2022 | Oct 21, 2022 |
|
2571 | Activation, AhR | Increased, Migration (Endothelial Cells) | Feb 15, 2022 | Feb 29, 2024 |
|
2572 | Activation, AhR | Increased, Invasion | Feb 15, 2022 | Mar 5, 2024 |
|
2570 | Activation, AhR | Increased, Motility | Feb 15, 2022 | Feb 29, 2024 |
|
2569 | Activation, AhR | Apoptosis | Feb 15, 2022 | Dec 20, 2022 |
|
2568 | Activation, AhR | Increase, Inflammation | Feb 15, 2022 | Mar 5, 2024 |
|
1656 | Activation, AhR | Up Regulation, SCD-1 | Aug 31, 2017 | Aug 31, 2017 |
|
1384 | Agonism, Androgen receptor | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | Mar 17, 2017 | Mar 20, 2017 |
|
1385 | Agonism, Androgen receptor | Reduction, Vitellogenin synthesis in liver | Mar 17, 2017 | Mar 20, 2017 |
|
3392 | Agonism, Androgen receptor | Altered, Transcription of genes by the AR | Nov 16, 2024 | Nov 16, 2024 |
|
2926 | Agonism, Androgen receptor | Reduction, the ratio of E2/11-KT in plasma | May 22, 2023 | May 22, 2023 | |
2918 | Agonism, Androgen receptor | Increased, gene expression of AR | May 22, 2023 | May 22, 2023 | |
3378 | Agonism, Androgen receptor | Androgen receptor activation, increased | Nov 2, 2024 | Nov 24, 2024 |
|
31 | Agonism, Androgen receptor | Reduction, Gonadotropins, circulating concentrations | Nov 29, 2016 | Mar 20, 2017 |
|
32 | Agonism, Androgen receptor | Reduction, Testosterone synthesis by ovarian theca cells | Nov 29, 2016 | Mar 20, 2017 |
|
2349 | Agonism, Androgen receptor | Increased, Male Biased Sex Ratio | Apr 12, 2021 | Jan 3, 2023 |
|
2260 | Agonism, Androgen receptor | Increased, Differentiation to Testis | Jan 12, 2021 | Jan 3, 2023 |
|
2201 | Antagonism, Androgen receptor | Altered, Transcription of genes by the AR | Nov 2, 2020 | Feb 2, 2021 |
|
3397 | Antagonism, Androgen receptor | Alteration, Wnt pathway | Nov 18, 2024 | Nov 18, 2024 |
|
2123 | Antagonism, Androgen receptor | AGD, decreased | May 11, 2020 | Aug 7, 2020 | |
2133 | Antagonism, Androgen receptor | nipple retention, increased | May 11, 2020 | Jan 11, 2023 |
|
2130 | Antagonism, Androgen receptor | Decrease, AR activation | May 11, 2020 | Apr 5, 2024 |
|
36 | Reduction, Angiogenesis | Impairment, Endothelial network | Nov 29, 2016 | Jan 18, 2022 |
|
43 | Decrease, Aromatase (Cyp19a1) | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | Nov 29, 2016 | Dec 3, 2016 | |
45 | Inhibition, Aromatase | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | Nov 29, 2016 | Nov 30, 2016 |
|
3394 | Inhibition, Aromatase | Inhibition, plasma aromatase activity | Nov 16, 2024 | Nov 16, 2024 |
|
1767 | Inhibition, Aromatase | Altered regulation, Alpha hemoglobin | Sep 13, 2018 | Sep 13, 2018 | |
2167 | Inhibition, Aromatase | Increased, Differentiation to Testis | Jul 28, 2020 | Dec 28, 2022 |
|
2350 | Inhibition, Aromatase | Increased, Male Biased Sex Ratio | Apr 13, 2021 | Jan 10, 2023 |
|
2144 | Inhibition, Aromatase | Reduction, E2 Synthesis by the undifferentiated gonad | Jun 15, 2020 | Jul 11, 2022 |
|
2011 | Increased Cholinergic Signaling | Impaired coordination and movement | Dec 20, 2019 | Dec 20, 2019 |
|
2005 | Increased Cholinergic Signaling | Cardiovascular dysregulation | Nov 25, 2019 | Dec 20, 2019 |
|
51 | Increased Cholinergic Signaling | Decrease, Population growth rate | Nov 29, 2016 | Dec 3, 2016 | |
434 | Increased Cholinergic Signaling | Increased Mortality | Nov 29, 2016 | Dec 3, 2016 | |
457 | Increased Cholinergic Signaling | Respiratory distress/arrest | Nov 29, 2016 | Dec 20, 2019 |
|
2412 | Increased Cholinergic Signaling | Cognitive function, decreased | Jun 24, 2021 | Sep 1, 2021 |
|
2410 | Increased Cholinergic Signaling | Neuronal network function, Decreased | Jun 24, 2021 | Sep 1, 2021 |
|
1873 | Decrease, Mitochondrial ATP production | Increase, Necrosis | Mar 19, 2019 | Mar 19, 2019 | |
1601 | Decrease, Mitochondrial ATP production | Decrease, Oogenesis | Jun 29, 2017 | Jun 29, 2017 | |
1670 | Decrease, Mitochondrial ATP production | Decrease, Leaf cell mitosis | Oct 10, 2017 | Oct 10, 2017 |
|
1682 | Decrease, Mitochondrial ATP production | Increase, Cytotoxicity (renal tubular cell) | Oct 25, 2017 | Oct 25, 2017 |
|
1739 | Decrease, Mitochondrial ATP production | Decrease, Growth | May 24, 2018 | May 24, 2018 | |
1750 | Decrease, Mitochondrial ATP production | Increase, Apoptosis | Jun 12, 2018 | Jun 12, 2018 | |
2823 | Decrease, Mitochondrial ATP production | Decrease, Cardiac contractility | Jan 5, 2023 | Jan 5, 2023 |
|
2551 | Decrease, Mitochondrial ATP production | Decrease, Reproduction | Jan 21, 2022 | Jan 21, 2022 |
|
927 | Inhibition, Bile Salt Export Pump (ABCB11) | Bile accumulation, Pathological condition | Nov 29, 2016 | Dec 3, 2016 |
|
59 | Reduction, Ca and HCO3 transport to shell gland | Reduction, Eggshell thickness | Nov 29, 2016 | Dec 3, 2016 |
|
60 | Increase, Ca++ (intracellular) | Disruption, Mitochondrial electron transport chain | Nov 29, 2016 | Dec 3, 2016 |
|
61 | Inhibition, Ca++ ATPase | Increase, Ca++ (intracellular) | Nov 29, 2016 | Dec 3, 2016 |
|
62 | Decreased, Calcium influx | Impairment, Learning and memory | Nov 29, 2016 | Dec 3, 2016 | |
347 | Decreased, Calcium influx | BDNF, Reduced | Nov 29, 2016 | Jun 13, 2018 |
|
66 | Up Regulation, CD36 | Increase, FA Influx | Nov 29, 2016 | Mar 27, 2024 |
|
501 | Up Regulation, CD36 | Increased, FA Influx | Nov 29, 2016 | Dec 3, 2016 |
|
2262 | Up Regulation, CD36 | Increased, Fatty acid uptake | Jan 15, 2021 | Jan 15, 2021 | |
924 | Cell injury/death | Release, Cytokine | Nov 29, 2016 | Nov 9, 2018 | |
67 | Cell injury/death | Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) | Nov 29, 2016 | Nov 29, 2016 | |
68 | Cell injury/death | Activation, Stellate cells | Nov 29, 2016 | Nov 29, 2016 |
|
355 | Cell injury/death | Synaptogenesis, Decreased | Nov 29, 2016 | Nov 29, 2016 |
|
364 | Cell injury/death | N/A, Neurodegeneration | Nov 29, 2016 | Sep 10, 2023 |
|
365 | Cell injury/death | Neuroinflammation | Nov 29, 2016 | Jul 15, 2022 |
|
1863 | Cell injury/death | Neurodegeneration | Feb 19, 2019 | Feb 19, 2019 | |
1831 | Cell injury/death | Activation, Tissue resident cells (Kuppfer cells) | Jan 7, 2019 | Jan 7, 2019 |
|
1830 | Cell injury/death | Necrotic Tissue | Jan 7, 2019 | Mar 7, 2019 |
|
1776 | Cell injury/death | Increased pro-inflammatory mediators | Nov 12, 2018 | Nov 12, 2018 |
|
1718 | Cell injury/death | Tissue resident cell activation | Feb 1, 2018 | Aug 2, 2018 |
|
1688 | Cell injury/death | Neuronal network function, Decreased | Nov 9, 2017 | Feb 5, 2020 |
|
2890 | Cell injury/death | Leukocyte recruitment/activation | Apr 13, 2023 | Apr 13, 2023 | |
2875 | Cell injury/death | Hippocampal Physiology, Altered | Apr 5, 2023 | Apr 5, 2023 |
|
3197 | Cell injury/death | Disruption of the intestinal barrier | Apr 17, 2024 | Apr 17, 2024 |
|
3198 | Cell injury/death | Mitochondrial dysfunction | Apr 17, 2024 | Apr 17, 2024 | |
3244 | Cell injury/death | Increase, Cardiac remodelling | Jun 4, 2024 | Jun 4, 2024 |
|
3245 | Cell injury/death | Decrease, Cardiac contractility | Jun 4, 2024 | Jun 4, 2024 |
|
2767 | Cell injury/death | Decrease, Growth | Sep 27, 2022 | Sep 27, 2022 |
|
69 | Proliferation, Cell proliferation in the absence of cytotoxicity | Hyperplasia, Hyperplasia | Nov 29, 2016 | Dec 3, 2016 |
|
70 | Induction, Chitin degradation and resorption | Induction, Pre-mature molting | Nov 29, 2016 | Dec 3, 2016 | |
667 | Reduction, Ionotropic GABA receptor chloride channel conductance | Reduction, Neuronal synaptic inhibition | Nov 29, 2016 | Apr 29, 2019 |
|
483 | Activation, ChREBP | Increased, De Novo FA synthesis | Nov 29, 2016 | Dec 3, 2016 |
|
77 | Activation, ChREBP | Synthesis, De Novo Fatty Acid (FA) | Nov 29, 2016 | Dec 3, 2016 |
|
82 | Accumulation, Collagen | N/A, Liver fibrosis | Nov 29, 2016 | Dec 5, 2018 |
|
1629 | Accumulation, Collagen | Pulmonary fibrosis | Jul 26, 2017 | May 18, 2023 |
|
2139 | Accumulation, Collagen | Lung fibrosis | May 15, 2020 | May 15, 2020 |
|
1700 | N/A, Covalent binding to protein, possibly lysine residue | Activation, Dendritic Cells | Dec 7, 2017 | Sep 24, 2020 | |
88 | N/A, Covalent binding to protein, possibly lysine residue | Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways | Nov 29, 2016 | Sep 24, 2020 | |
93 | Production, Critical Metabolites (CGA 330050 and CGA 265307) | Induction, Liver “Dysfunctional” Changes by CGA 330050 | Nov 29, 2016 | Dec 3, 2016 |
|
94 | Reduction, Cumulative fecundity and spawning | Decrease, Population growth rate | Nov 29, 2016 | Mar 20, 2017 |
|
2142 | Reduction, Cumulative fecundity and spawning | Decline, Population | May 25, 2020 | May 25, 2020 | |
2924 | Reduction, Cumulative fecundity and spawning | Decreased, Population trajectory | May 22, 2023 | May 22, 2023 |
|
95 | Inhibition, Cyclooxygenase activity | Reduction, Prostaglandin E2 concentration | Nov 29, 2016 | Dec 3, 2016 |
|
670 | Inhibition, Cyclooxygenase activity | Reduced, Prostaglandin F2alpha synthesis, ovary | Nov 29, 2016 | Dec 3, 2016 |
|
681 | Inhibition, Cyclooxygenase activity | Decreased, Prostaglandin F2alpha synthesis, ovary | Nov 29, 2016 | Dec 3, 2016 |
|
686 | Inhibition, Cyclooxygenase activity | Reduced, Prostaglandins, ovary | Nov 29, 2016 | Dec 3, 2016 |
|
689 | Inhibition, Cyclooxygenase activity | Reduced, Prostaglandin E2 concentration, hypothalamus | Nov 29, 2016 | Dec 3, 2016 |
|
96 | Up Regulation, CYP1A1 | Peptide Oxidation | Nov 29, 2016 | Dec 3, 2016 | |
2887 | Up Regulation, CYP1A1 | Increase, ROS formation | Apr 13, 2023 | Apr 13, 2023 | |
104 | Up Regulation, CYP1B1 | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | Nov 29, 2016 | Dec 3, 2016 | |
108 | Release, Cytokine | Increase, Inflammation | Nov 29, 2016 | Dec 3, 2016 |
|
925 | Release, Cytokine | Infiltration, Inflammatory cytokines | Nov 29, 2016 | Dec 3, 2016 | |
994 | Release, Cytokine | Infiltration, Inflammatory cells | Nov 29, 2016 | Nov 29, 2016 | |
2455 | Release, Cytokine | Neutrophil activation, Increased | Aug 4, 2021 | Aug 4, 2021 |
|
2454 | Release, Cytokine | Platelet activation, Increased | Aug 4, 2021 | Aug 4, 2021 |
|
1963 | Release, Cytokine | Recruitment of inflammatory cells | Jul 3, 2019 | Jul 3, 2019 |
|
110 | Synthesis, De Novo Fatty Acid (FA) | Accumulation, Triglyceride | Nov 29, 2016 | Mar 29, 2024 |
|
23 | Alkylation, DNA | Increase, Heritable mutations in offspring | Nov 29, 2016 | Nov 29, 2016 |
|
24 | Alkylation, DNA | Inadequate DNA repair | Nov 29, 2016 | Dec 10, 2019 |
|
25 | Alkylation, DNA | Increase, Mutations | Nov 29, 2016 | Nov 29, 2016 |
|
901 | Alkylation, DNA | Increase, Cancer | Nov 29, 2016 | Dec 3, 2016 |
|
999 | Increase, EcR agonism | Decreased, synthesis and secretion of molting fluid proteases | Nov 29, 2016 | Dec 3, 2016 | |
998 | Increase, EcR agonism | Decrease, Circulating ETH | Nov 29, 2016 | Dec 3, 2016 | |
1007 | Increase, EcR agonism | Decreased, Synthesis of molting fluid proteases | Nov 29, 2016 | Dec 3, 2016 | |
116 | Increase, EcR agonism | Induction, Chitin degradation and resorption | Nov 29, 2016 | Dec 3, 2016 | |
1343 | Increase, EcR agonism | Increase, E75b expression | Feb 9, 2017 | Feb 9, 2017 |
|
3241 | Inhibition, ETC complexes of the respiratory chain | Oxidative Stress | May 31, 2024 | May 31, 2024 |
|
2636 | Inhibition, ETC complexes of the respiratory chain | Decrease, MMP | Apr 8, 2022 | Apr 8, 2022 |
|
2821 | Inhibition, ETC complexes of the respiratory chain | Mitochondrial dysfunction | Jan 5, 2023 | Jan 5, 2023 |
|
2565 | Inhibition, ETC complexes of the respiratory chain | Increase, Oxidative Stress | Feb 8, 2022 | Mar 7, 2022 | |
123 | Reduction, Eggshell thickness | N/A, Reproductive failure | Nov 29, 2016 | Dec 3, 2016 |
|
125 | Impairment, Endothelial network | Insufficiency, Vascular | Nov 29, 2016 | Jan 18, 2022 |
|
976 | Impairment, Endothelial network | Altered, Cardiovascular development/function | Nov 29, 2016 | Jun 9, 2017 |
|
126 | Agonism, Estrogen receptor | Altered, Reproductive behaviour | Nov 29, 2016 | Dec 3, 2016 |
|
127 | Agonism, Estrogen receptor | Impaired development of, Reproductive organs | Nov 29, 2016 | Dec 3, 2016 |
|
128 | Agonism, Estrogen receptor | Increase, Vitellogenin synthesis in liver | Nov 29, 2016 | Jun 24, 2024 |
|
129 | Antagonism, Estrogen receptor | Reduction, Vitellogenin synthesis in liver | Nov 29, 2016 | Nov 30, 2016 |
|
3120 | Antagonism, Estrogen receptor | inhibition, EKR1/2 signaling pathway | Jan 25, 2024 | Jan 25, 2024 |
|
2613 | Antagonism, Estrogen receptor | EMT | Mar 22, 2022 | Aug 27, 2023 |
|
132 | Increase, FA Influx | Accumulation, Triglyceride | Nov 29, 2016 | Mar 29, 2024 |
|
133 | Activation, FAS | Synthesis, De Novo Fatty Acid (FA) | Nov 29, 2016 | Dec 3, 2016 |
|
1422 | Activation, FAS | Increased, lipogenesis | Apr 13, 2017 | Apr 13, 2017 | |
136 | N/A, Gap | Reduction, Ca and HCO3 transport to shell gland | Nov 29, 2016 | Dec 3, 2016 |
|
385 | Activation, Glucocorticoid Receptor | Induction, IKB inhibitory protein | Nov 29, 2016 | Dec 3, 2016 |
|
1451 | Activation, Glucocorticoid Receptor | Reduced, BDNF | Apr 14, 2017 | Apr 14, 2017 |
|
2261 | Activation, Glucocorticoid Receptor | Up Regulation, CD36 | Jan 15, 2021 | Jan 15, 2021 | |
2266 | Activation, Glucocorticoid Receptor | Decrease, ACAD | Jan 15, 2021 | Jan 15, 2021 |
|
2039 | Activation, Glucocorticoid Receptor | Decreased, Mitochondrial Fatty Acid Beta Oxidation | Feb 22, 2020 | Feb 22, 2020 | |
2041 | Activation, Glucocorticoid Receptor | Decreased, PPAR-alpha activation | Feb 22, 2020 | Feb 22, 2020 | |
2077 | Activation, Glucocorticoid Receptor | Increase, Cripto-1 expression | Apr 20, 2020 | Jul 10, 2020 |
|
143 | Reduction, Gonadotropins, circulating concentrations | Reduction, Testosterone synthesis by ovarian theca cells | Nov 29, 2016 | Mar 20, 2017 |
|
2878 | Depletion, GSH | Increased, Reactive oxygen species | Apr 5, 2023 | Sep 14, 2023 |
|
146 | Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) | Peptide Oxidation | Nov 29, 2016 | Dec 3, 2016 | |
147 | Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) | Up Regulation, TGFbeta1 expression | Nov 29, 2016 | Nov 29, 2016 | |
996 | N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects | Alterations, Cellular proliferation / hyperplasia | Nov 29, 2016 | Dec 2, 2016 |
|
154 | Decreased, HSD17B10 expression | Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity | Nov 29, 2016 | Dec 3, 2016 |
|
158 | Hyperplasia, Hyperplasia | Promotion, Hepatocelluar carcinoma | Nov 29, 2016 | Dec 3, 2016 |
|
386 | Induction, IKB inhibitory protein | Inhibition, Nuclear factor kappa B (NF-kB) | Nov 29, 2016 | Dec 3, 2016 |
|
159 | Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 | Induction, Sustained Hepatotoxicity | Nov 29, 2016 | Dec 3, 2016 |
|
781 | Increase, Inflammation | Increase, Regenerative cell proliferation (forestomach epithelial cells) | Nov 29, 2016 | Dec 3, 2016 |
|
929 | Increase, Inflammation | Cholestasis, Pathology | Nov 29, 2016 | Dec 3, 2016 |
|
3358 | Increase, Inflammation | Demyelination, increased | Oct 1, 2024 | Oct 1, 2024 |
|
3357 | Increase, Inflammation | Oligodendrocyte death, increased | Oct 1, 2024 | Oct 1, 2024 |
|
2976 | Increase, Inflammation | General Apoptosis | Jul 31, 2023 | Oct 19, 2023 |
|
2573 | Increase, Inflammation | Increased, Invasion | Feb 15, 2022 | Mar 5, 2024 |
|
2574 | Increase, Inflammation | Increase, angiogenesis | Feb 15, 2022 | Dec 20, 2022 |
|
1724 | Increase, Inflammation | EMT | Mar 18, 2018 | Jan 30, 2019 |
|
1722 | Increase, Inflammation | Expression of Collagen | Mar 18, 2018 | Mar 18, 2018 | |
1839 | Increase, Inflammation | Fibroproliferative airway lesions | Jan 30, 2019 | Jan 30, 2019 |
|
1699 | Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways | Activation, Dendritic Cells | Dec 7, 2017 | Dec 3, 2020 | |
388 | Suppression, Inflammatory cytokines | Decreased, Lymphocytes | Nov 29, 2016 | Dec 3, 2016 |
|
164 | Inadequate DNA repair | Increase, Mutations | Nov 29, 2016 | Mar 8, 2024 |
|
1910 | Inadequate DNA repair | Increase, DNA strand breaks | May 19, 2019 | Jan 9, 2023 |
|
1912 | Inadequate DNA repair | Increase, Chromosomal aberrations | May 19, 2019 | Mar 8, 2024 |
|
2817 | Inadequate DNA repair | Cataracts | Dec 18, 2022 | Mar 11, 2024 |
|
168 | N/A, Interferences with SH-/selen-proteins | Depletion, GSH | Nov 29, 2016 | Dec 3, 2016 | |
169 | Increase, Liver and splenic hemosiderosis | N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number | Nov 29, 2016 | Dec 3, 2016 |
|
170 | Induction, Liver “Dysfunctional” Changes by CGA 330050 | Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 | Nov 29, 2016 | Dec 3, 2016 |
|
172 | Activation, Long term AHR receptor driven direct and indirect gene expression changes | N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects | Nov 29, 2016 | Nov 29, 2016 |
|
874 | Activation, Long term AHR receptor driven direct and indirect gene expression changes | Changes/Inhibition, Cellular Homeostasis and Apoptosis | Nov 29, 2016 | Nov 29, 2016 |
|
875 | Activation, Long term AHR receptor driven direct and indirect gene expression changes | Alterations, Cellular proliferation / hyperplasia | Nov 29, 2016 | Nov 29, 2016 |
|
876 | Activation, Long term AHR receptor driven direct and indirect gene expression changes | Formation, Hepatocellular and Bile duct tumors | Nov 29, 2016 | Nov 29, 2016 |
|
479 | Activation, LXR | Activation, SREBF1 | Nov 29, 2016 | Dec 3, 2016 |
|
490 | Activation, LXR | Up Regulation, FAS | Nov 29, 2016 | Dec 3, 2016 |
|
491 | Activation, LXR | Up Regulation, SCD-1 | Nov 29, 2016 | Dec 3, 2016 |
|
510 | Activation, LXR | Inhibition, PPAR alpha | Nov 29, 2016 | Dec 3, 2016 |
|
516 | Activation, LXR | Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) | Nov 29, 2016 | Dec 3, 2016 |
|
177 | Activation, LXR | Activation, SREBP-1c | Nov 29, 2016 | Dec 3, 2016 |
|
176 | Activation, LXR | Activation, SCD-1 | Nov 29, 2016 | Dec 3, 2016 |
|
174 | Activation, LXR | Activation, ChREBP | Nov 29, 2016 | Dec 3, 2016 |
|
173 | Activation, LXR | Up Regulation, CD36 | Nov 29, 2016 | Dec 3, 2016 |
|
175 | Activation, LXR | Activation, FAS | Nov 29, 2016 | Dec 3, 2016 |
|
3103 | Activation, LXR | Increased, Expression of LXR activated genes | Dec 7, 2023 | Mar 29, 2024 |
|
390 | Decreased, Lymphocytes | Suppression, Immune system | Nov 29, 2016 | Dec 3, 2016 |
|
389 | Decreased, Lymphocytes | Increased, Disease susceptibility | Nov 29, 2016 | Dec 3, 2016 | |
182 | N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number | N/A, Cyanosis occurs | Nov 29, 2016 | Dec 3, 2016 |
|
363 | Mitochondrial dysfunction | Cell injury/death | Nov 29, 2016 | Nov 29, 2016 |
|
3136 | Mitochondrial dysfunction | Proteasomal dysfunction | Feb 29, 2024 | Feb 29, 2024 |
|
3134 | Mitochondrial dysfunction | Increase, Cytotoxicity (renal tubular cell) | Feb 28, 2024 | Mar 6, 2024 |
|
3132 | Mitochondrial dysfunction | increased,Vascular endothelial dysfunction | Feb 21, 2024 | Feb 21, 2024 |
|
3131 | Mitochondrial dysfunction | Increase, Apoptosis | Feb 21, 2024 | Feb 21, 2024 |
|
3156 | Mitochondrial dysfunction | Occurrence, Ballooning degeneration (hepatocyte) | Mar 13, 2024 | Mar 13, 2024 |
|
3155 | Mitochondrial dysfunction | Occurrence, Cytoplasmic vacuolization (hepatocyte) | Mar 13, 2024 | Mar 13, 2024 |
|
3153 | Mitochondrial dysfunction | ER stress | Mar 13, 2024 | Mar 13, 2024 |
|
3141 | Mitochondrial dysfunction | Increased, Reactive oxygen species | Mar 6, 2024 | Apr 11, 2024 |
|
3165 | Mitochondrial dysfunction | Inhibition, Nuclear factor kappa B (NF-kB) | Mar 14, 2024 | Mar 14, 2024 |
|
3164 | Mitochondrial dysfunction | Altered expression of NRF2 pathway-dependent genes | Mar 14, 2024 | Mar 14, 2024 |
|
3152 | Mitochondrial dysfunction | Apoptotic cell death | Mar 13, 2024 | Mar 13, 2024 |
|
3161 | Mitochondrial dysfunction | Impaired insulin signaling | Mar 13, 2024 | Mar 13, 2024 |
|
3146 | Mitochondrial dysfunction | Apoptosis | Mar 13, 2024 | Mar 13, 2024 |
|
3157 | Mitochondrial dysfunction | Occurrence, Cytoplasmic vacuolization (kupffer cell) | Mar 13, 2024 | Mar 13, 2024 |
|
3158 | Mitochondrial dysfunction | Occurrence, Cytoplasmic vacuolization (Bile duct cell) | Mar 13, 2024 | Mar 13, 2024 |
|
3149 | Mitochondrial dysfunction | Necrosis | Mar 13, 2024 | Mar 13, 2024 |
|
3150 | Mitochondrial dysfunction | cell injury | Mar 13, 2024 | Mar 13, 2024 |
|
582 | Mitochondrial dysfunction | Neuronal network function, Decreased | Nov 29, 2016 | Dec 3, 2016 |
|
660 | Mitochondrial dysfunction | Overwhelmed, Mitochondrial DNA repair mechanisms | Nov 29, 2016 | Dec 3, 2016 |
|
664 | Mitochondrial dysfunction | impaired, Thoracic shivering | Nov 29, 2016 | Dec 3, 2016 | |
904 | Mitochondrial dysfunction | Impaired, Proteostasis | Nov 29, 2016 | Aug 25, 2017 |
|
908 | Mitochondrial dysfunction | Degeneration of dopaminergic neurons of the nigrostriatal pathway | Nov 29, 2016 | Aug 25, 2017 |
|
2822 | Mitochondrial dysfunction | Decrease, Mitochondrial ATP production | Jan 5, 2023 | Jan 5, 2023 |
|
1684 | Mitochondrial dysfunction | Oxidative Stress | Nov 9, 2017 | Nov 9, 2017 |
|
1152 | Mitochondrial dysfunction | impaired, Hive thermoregulation | Nov 29, 2016 | Dec 3, 2016 |
|
1154 | Mitochondrial dysfunction | Weakened, Colony | Nov 29, 2016 | Dec 3, 2016 |
|
1311 | Mitochondrial dysfunction | Altered, Ca2+-calmodulin activated signal transduction | Nov 29, 2016 | Dec 3, 2016 |
|
1958 | Mitochondrial dysfunction | Increased reactive oxygen species (in the mitochondria) | Jun 15, 2019 | Jun 15, 2019 |
|
2224 | Mitochondrial dysfunction | Increase, ROS | Dec 4, 2020 | Dec 4, 2020 | |
2227 | Mitochondrial dysfunction | Increase, ROS formation | Dec 4, 2020 | Dec 4, 2020 | |
2228 | Mitochondrial dysfunction | Decrease, ATP pool | Dec 4, 2020 | Dec 4, 2020 | |
188 | Disruption, Mitochondrial electron transport chain | Decrease, Mitochondrial ATP production | Nov 29, 2016 | Dec 3, 2016 |
|
189 | Disruption, Mitochondrial electron transport chain | Increase, ROS | Nov 29, 2016 | Dec 3, 2016 |
|
190 | Decreased, Mitochondrial fatty acid beta-oxidation | Accumulation, Fatty acid | Nov 29, 2016 | Dec 3, 2016 |
|
617 | Decreased, Mitochondrial fatty acid beta-oxidation | Increased, Liver Steatosis | Nov 29, 2016 | Dec 3, 2016 | |
3159 | Decreased, Mitochondrial fatty acid beta-oxidation | Mitochondrial dysfunction | Mar 13, 2024 | Mar 13, 2024 |
|
2931 | Decreased, Mitochondrial fatty acid beta-oxidation | Mitochondrial dysfunction EMPTY | May 25, 2023 | May 25, 2023 | |
3209 | Decreased, Mitochondrial fatty acid beta-oxidation | Disrupted Lipid Storage | May 8, 2024 | May 28, 2024 |
|
1025 | Abnormal, Morphogenesis | Increased, Developmental Defects | Nov 29, 2016 | Dec 3, 2016 | |
196 | Abnormal, Morphogenesis | Increased, Lethality | Nov 29, 2016 | Dec 3, 2016 | |
197 | Abnormal, Morphogenesis | Increased, Structural malformations | Nov 29, 2016 | Dec 3, 2016 | |
202 | Increase, Mutations | Increase, Heritable mutations in offspring | Nov 29, 2016 | Nov 29, 2016 |
|
899 | Increase, Mutations | Increase, Cancer | Nov 29, 2016 | Dec 3, 2016 |
|
2609 | Increase, Mutations | Increase,miRNA levels | Mar 22, 2022 | Aug 27, 2023 |
|
1984 | Increase, Mutations | Increase, lung cancer | Aug 29, 2019 | Jan 10, 2023 |
|
1978 | Increase, Mutations | Increase, Cell Proliferation | Aug 29, 2019 | Mar 8, 2024 |
|
1896 | Increase, Mutations | Increase, Cell Proliferation (Epithelial Cells) | May 7, 2019 | May 8, 2019 |
|
203 | Altered, Neuroanatomy | Altered, Neurophysiology | Nov 29, 2016 | Nov 29, 2016 |
|
208 | Neuroinflammation | N/A, Neurodegeneration | Nov 29, 2016 | Feb 23, 2021 |
|
3255 | Neuroinflammation | Impairment, Learning and memory | Jun 19, 2024 | Jun 19, 2024 |
|
2288 | Neuroinflammation | Encephalitis | Feb 23, 2021 | Feb 23, 2021 |
|
2500 | Neuroinflammation | Neuronal network function, Decreased | Oct 26, 2021 | Oct 26, 2021 |
|
906 | Neuroinflammation | Degeneration of dopaminergic neurons of the nigrostriatal pathway | Nov 29, 2016 | Aug 25, 2017 |
|
759 | Neuroinflammation | Synaptogenesis, Decreased | Nov 29, 2016 | Dec 3, 2016 | |
1687 | Neuroinflammation | Cell injury/death | Nov 9, 2017 | Nov 7, 2019 |
|
2717 | Neuroinflammation | Increase, Cell death | Jul 25, 2022 | Jul 25, 2022 | |
210 | Neuronal dysfunction | Neuroinflammation | Nov 29, 2016 | Nov 29, 2016 | |
2941 | Neuronal dysfunction | Neurological disorder | Jun 15, 2023 | Jun 15, 2023 |
|
384 | Altered, Neurophysiology | Cognitive function, decreased | Nov 29, 2016 | Nov 29, 2016 |
|
212 | Decreased, Nitric Oxide | Decreased, Long-term potentiation (LTP) | Nov 29, 2016 | Dec 3, 2016 |
|
214 | Inhibition, NMDARs | Impairment, Learning and memory | Nov 29, 2016 | Dec 3, 2016 | |
213 | Inhibition, NMDARs | Decreased, Calcium influx | Nov 29, 2016 | Apr 7, 2018 |
|
215 | Inhibition, NMDARs | Neuronal dysfunction | Nov 29, 2016 | Dec 3, 2016 | |
3124 | Inhibition, NMDARs | Aberrant, synaptic formation and plasticity | Jan 25, 2024 | Jan 25, 2024 |
|
228 | Binding of antagonist, NMDA receptors | Impairment, Learning and memory | Nov 29, 2016 | Dec 3, 2016 | |
229 | Binding of antagonist, NMDA receptors | Inhibition, NMDARs | Nov 29, 2016 | Jun 13, 2018 |
|
387 | Inhibition, Nuclear factor kappa B (NF-kB) | Suppression, Inflammatory cytokines | Nov 29, 2016 | Dec 3, 2016 |
|
1871 | Inhibition, Nuclear factor kappa B (NF-kB) | Impairment of TDAR | Mar 12, 2019 | Mar 12, 2019 | |
1828 | Inhibition, Nuclear factor kappa B (NF-kB) | Activation, Caspase 8 pathway | Jan 7, 2019 | Mar 7, 2019 |
|
1921 | Inhibition, Nuclear factor kappa B (NF-kB) | Impaired T cell activation | May 23, 2019 | Jun 25, 2019 | |
2644 | Inhibition, Nuclear factor kappa B (NF-kB) | Increase in inflammation | Apr 8, 2022 | Apr 8, 2022 |
|
2306 | Inhibition, Nuclear factor kappa B (NF-kB) | Increased proinflammatory mediators | Mar 30, 2021 | Mar 30, 2021 | |
2003 | Inhibition, Nuclear factor kappa B (NF-kB) | Suppression of T cell activation | Nov 17, 2019 | Mar 2, 2023 |
|
236 | Peptide Oxidation | Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) | Nov 29, 2016 | Dec 3, 2016 | |
1698 | Peptide Oxidation | S-Glutathionylation, eNOS | Nov 16, 2017 | Nov 20, 2017 |
|
1379 | Peptide Oxidation | Activation, JNK | Feb 15, 2017 | Feb 15, 2017 |
|
1467 | Peptide Oxidation | Increase, DNA Damage | Apr 15, 2017 | Apr 15, 2017 | |
1237 | Peptide Oxidation | Increased activation, Nuclear factor kappa B (NF-kB) | Nov 29, 2016 | Dec 3, 2016 | |
764 | Peptide Oxidation | Increase, hepatocellular adenomas and carcinomas | Nov 29, 2016 | Dec 3, 2016 | |
765 | Peptide Oxidation | Increase, Cytotoxicity | Nov 29, 2016 | Dec 3, 2016 |
|
980 | Peptide Oxidation | Decrease, GTPCH-1 | Nov 29, 2016 | Sep 28, 2017 |
|
992 | Peptide Oxidation | Decrease, AKT/eNOS activity | Nov 29, 2016 | Oct 16, 2017 |
|
932 | Peptide Oxidation | Cholestasis, Pathology | Nov 29, 2016 | Dec 3, 2016 |
|
922 | Peptide Oxidation | Mitochondrial dysfunction | Nov 29, 2016 | Nov 29, 2016 | |
923 | Peptide Oxidation | Release, Cytokine | Nov 29, 2016 | Dec 3, 2016 | |
948 | Peptide Oxidation | Oxidation, Glutathione | Nov 29, 2016 | Nov 29, 2016 | |
3323 | N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin | Oxidative Stress | Jul 24, 2024 | Jul 24, 2024 |
|
242 | N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin | Altered regulation, Alpha hemoglobin | Nov 29, 2016 | Dec 3, 2016 |
|
243 | N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin | Formation, Formation of hemoglobin adducts | Nov 29, 2016 | Dec 3, 2016 |
|
245 | N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin | Damaging, Red blood cells; hemolysis | Nov 29, 2016 | Dec 3, 2016 |
|
248 | Bile accumulation, Pathological condition | Activation of specific nuclear receptors, Transcriptional change | Nov 29, 2016 | Dec 3, 2016 |
|
930 | Bile accumulation, Pathological condition | Production, Reactive oxygen species | Nov 29, 2016 | Dec 3, 2016 |
|
928 | Bile accumulation, Pathological condition | Release, Cytokine | Nov 29, 2016 | Dec 3, 2016 |
|
503 | Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) | Accumulation, Fatty acid | Nov 29, 2016 | Dec 3, 2016 |
|
392 | Reduction, Plasma 17beta-estradiol concentrations | irregularities, ovarian cycle | Nov 29, 2016 | Dec 3, 2016 |
|
253 | Reduction, Plasma 17beta-estradiol concentrations | Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development | Nov 29, 2016 | Nov 29, 2016 | |
252 | Reduction, Plasma 17beta-estradiol concentrations | Reduction, Vitellogenin synthesis in liver | Nov 29, 2016 | Mar 20, 2017 |
|
2922 | Reduction, Plasma 17beta-estradiol concentrations | Reduction, the ratio of E2/11-KT in plasma | May 22, 2023 | May 22, 2023 |
|
1386 | Reduction, Plasma 17beta-estradiol concentrations | Reduction, Plasma vitellogenin concentrations | Mar 17, 2017 | Oct 18, 2018 |
|
3259 | Increase, Plasma vitellogenin concentrations | Impaired development of, Reproductive organs | Jul 3, 2024 | Jul 3, 2024 |
|
254 | Increase, Plasma vitellogenin concentrations | Increase, Renal pathology due to VTG deposition | Nov 29, 2016 | Jun 24, 2024 |
|
255 | Reduction, Plasma vitellogenin concentrations | Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development | Nov 29, 2016 | Mar 20, 2017 |
|
1882 | Reduction, Plasma vitellogenin concentrations | Reduction, egg production and spawning | Apr 18, 2019 | Apr 18, 2019 | |
1769 | Reduction, Plasma vitellogenin concentrations | Reduction, Cumulative fecundity and spawning | Sep 18, 2018 | Sep 18, 2018 |
|
369 | Activation, PPARα | Decrease, Steroidogenic acute regulatory protein (STAR) | Nov 29, 2016 | Dec 2, 2016 |
|
370 | Activation, PPARα | Decrease, Translocator protein (TSPO) | Nov 29, 2016 | Dec 2, 2016 |
|
2134 | Activation, PPARα | Decreased, 11KT | May 11, 2020 | May 11, 2020 | |
2073 | Activation, PPARα | Decreased, cholesterol | Apr 6, 2020 | May 1, 2020 |
|
535 | Activation, PPARα | Activation, LXR alpha | Nov 29, 2016 | Dec 3, 2016 |
|
2252 | Activation, PPARα | Increase, cell proliferation (hepatocytes) | Dec 31, 2020 | Dec 31, 2020 |
|
2253 | Activation, PPARα | Increase, hepatocellular adenomas and carcinomas | Dec 31, 2020 | Dec 31, 2020 |
|
1410 | Activation, PPARα | Activation, HSD17B4 | Apr 12, 2017 | Apr 12, 2017 | |
1229 | Activation, PPARα | Increase, Phenotypic enzyme activity | Nov 29, 2016 | Dec 31, 2020 |
|
1233 | Activation, PPARα | Increase, Genes involved in fatty acid oxidation | Nov 29, 2016 | Dec 3, 2016 | |
1236 | Activation, PPARα | Activation, NADPH Oxidase | Nov 29, 2016 | Dec 3, 2016 | |
1402 | demethylation, PPARg promoter | Activation, SREBP-1 | Apr 12, 2017 | Apr 12, 2017 | |
1424 | demethylation, PPARg promoter | Activation, FAS | Apr 13, 2017 | Apr 13, 2017 | |
1608 | demethylation, PPARg promoter | Activation of specific nuclear receptors, PPAR-gamma activation | Jul 24, 2017 | Jul 24, 2017 |
|
1659 | demethylation, PPARg promoter | Increased, FA Influx | Aug 31, 2017 | Aug 31, 2017 |
|
395 | demethylation, PPARg promoter | reduction in ovarian granulosa cells, Aromatase (Cyp19a1) | Nov 29, 2016 | Dec 3, 2016 | |
411 | demethylation, PPARg promoter | Up Regulation, CD36 | Nov 29, 2016 | Nov 29, 2016 |
|
256 | demethylation, PPARg promoter | Decrease, Aromatase (Cyp19a1) | Nov 29, 2016 | Dec 3, 2016 | |
2988 | demethylation, PPARg promoter | Activation of PPAR | Aug 20, 2023 | Aug 20, 2023 |
|
487 | demethylation, PPARg promoter | Activation, SREBF1 | Nov 29, 2016 | Dec 3, 2016 |
|
2042 | Decreased, PPAR-alpha activation | Increased, Liver Steatosis | Feb 22, 2020 | Feb 22, 2020 | |
257 | Decreased, PPAR-alpha activation | Decreased, HSD17B10 expression | Nov 29, 2016 | Dec 3, 2016 |
|
259 | Decreased, PPAR-beta activation | Decreased, HSD17B10 expression | Nov 29, 2016 | Dec 3, 2016 |
|
260 | Decreased, PPAR-gamma activation | Decreased, HSD17B10 expression | Nov 29, 2016 | Dec 3, 2016 |
|
3093 | Decreased, PPAR-gamma activation | Alteration, lipid metabolism | Oct 18, 2023 | Oct 19, 2023 |
|
261 | Induction, Pre-mature molting | Decrease, Fecundity | Nov 29, 2016 | Dec 3, 2016 | |
262 | Induction, Pre-mature molting | Increase, Mortality | Nov 29, 2016 | Dec 3, 2016 | |
263 | Induction, Pre-mature molting | Increased Mortality | Nov 29, 2016 | Dec 3, 2016 | |
2482 | Activation, Pregnane-X receptor, NR1l2 | Induction, Upregulation of glucuronyltransferase activity | Sep 14, 2021 | Sep 14, 2021 |
|
3365 | Activation, Pregnane-X receptor, NR1l2 | Decreased, INSIG1 protein activity | Oct 22, 2024 | Dec 3, 2024 |
|
3100 | Activation, Pregnane-X receptor, NR1l2 | Up Regulation, CD36 | Nov 30, 2023 | Mar 27, 2024 |
|
266 | Feminisation or incomplete development, Primary and accessory male sex organs | N/A, Impairment of reproductive capacity | Nov 29, 2016 | Dec 3, 2016 |
|
268 | Reduction, Prostaglandin E2 concentration | N/A, Gap | Nov 29, 2016 | Dec 3, 2016 |
|
269 | Alkylation, Protein | Cell injury/death | Nov 29, 2016 | Nov 29, 2016 |
|
271 | Alkylation, Protein | Peptide Oxidation | Nov 29, 2016 | Dec 3, 2016 | |
3135 | Alkylation, Protein | Mitochondrial dysfunction | Feb 28, 2024 | Feb 28, 2024 |
|
518 | Activation, PXR/SXR | Inhibition, FoxA2 | Nov 29, 2016 | Dec 3, 2016 |
|
526 | Activation, PXR/SXR | Up Regulation, SCD-1 | Nov 29, 2016 | Dec 3, 2016 |
|
529 | Activation, PXR/SXR | Up Regulation, CD36 | Nov 29, 2016 | Dec 3, 2016 |
|
272 | Increase, RBC congestion in liver | N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number | Nov 29, 2016 | Dec 3, 2016 |
|
276 | Production, Reactive oxygen species | Peptide Oxidation | Nov 29, 2016 | Dec 3, 2016 |
|
931 | Production, Reactive oxygen species | Cholestasis, Pathology | Nov 29, 2016 | Dec 3, 2016 | |
277 | Damaging, Red blood cells; hemolysis | Increase, Liver and splenic hemosiderosis | Nov 29, 2016 | Dec 3, 2016 |
|
278 | Damaging, Red blood cells; hemolysis | N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number | Nov 29, 2016 | Dec 3, 2016 |
|
279 | Damaging, Red blood cells; hemolysis | Increase, RBC congestion in liver | Nov 29, 2016 | Dec 3, 2016 |
|
280 | Increase, Renal pathology due to VTG deposition | Altered, Larval development | Nov 29, 2016 | Dec 3, 2016 |
|
3258 | Increase, Renal pathology due to VTG deposition | Increased Mortality | Jun 24, 2024 | Jun 24, 2024 |
|
3238 | Increase, ROS | Oxidative Stress | May 31, 2024 | May 31, 2024 |
|
2998 | Increase, ROS | Increase, Oxidative Stress | Aug 21, 2023 | Aug 21, 2023 | |
282 | Increase, ROS | Decreased, Nitric Oxide | Nov 29, 2016 | Dec 3, 2016 |
|
912 | Increase, ROS | Mitochondrial dysfunction | Nov 29, 2016 | Dec 3, 2016 | |
1602 | Increase, ROS | Increase, DNA Damage | Jun 29, 2017 | Jun 29, 2017 | |
1603 | Increase, ROS | Increase, LPO | Jun 29, 2017 | Jun 29, 2017 |
|
1623 | Increase, ROS | Increased, secretion of local growth factors | Jul 26, 2017 | Jul 26, 2017 | |
1754 | Increase, ROS | Decrease, Coupling of OXPHOS | Jun 12, 2018 | Jun 12, 2018 |
|
2590 | Increase, ROS | Increase, Oxidative DNA damage | Mar 1, 2022 | Mar 1, 2022 |
|
2187 | Increase, ROS | Increase, Apoptosis | Nov 2, 2020 | Nov 2, 2020 | |
2225 | Increase, ROS | Increase, Global methylation | Dec 4, 2020 | Dec 4, 2020 | |
2305 | Increase, ROS | Inhibition, Nuclear factor kappa B (NF-kB) | Mar 30, 2021 | Mar 30, 2021 | |
2308 | Increase, ROS | Increased activation, Nuclear factor kappa B (NF-kB) | Mar 30, 2021 | Mar 30, 2021 | |
2348 | Increase, ROS | D1 protein deactivation | Apr 11, 2021 | Apr 11, 2021 | |
2093 | Increase, ROS | Decrease, MMP | Apr 30, 2020 | Apr 30, 2020 |
|
2089 | Increase, ROS | Increase, Protein oxidation | Apr 30, 2020 | Apr 30, 2020 |
|
284 | Activation, SCD-1 | Synthesis, De Novo Fatty Acid (FA) | Nov 29, 2016 | Dec 3, 2016 |
|
1404 | Activation, SCD-1 | Increased, lipogenesis | Apr 12, 2017 | Apr 12, 2017 | |
287 | Binding, SH-/selen-proteins | N/A, Interferences with SH-/selen-proteins | Nov 29, 2016 | Dec 3, 2016 | |
294 | Activation, SREBP-1c | Synthesis, De Novo Fatty Acid (FA) | Nov 29, 2016 | Dec 3, 2016 |
|
295 | Activation, Stellate cells | Accumulation, Collagen | Nov 29, 2016 | Dec 5, 2018 |
|
3217 | Activation, Stellate cells | Increased, Liver Steatosis | May 14, 2024 | May 14, 2024 | |
2892 | Activation, Stellate cells | Increased extracellular matrix deposition | Apr 13, 2023 | Apr 13, 2023 |
|
436 | Decrease, Steroidogenic acute regulatory protein (STAR) | Reduction, Cholesterol transport in mitochondria | Nov 29, 2016 | Dec 2, 2016 |
|
298 | Induction, Sustained Cell Proliferation | Formation, Liver tumor | Nov 29, 2016 | Dec 3, 2016 |
|
299 | Induction, Sustained Hepatotoxicity | Induction, Sustained Cell Proliferation | Nov 29, 2016 | Dec 3, 2016 |
|
301 | Activation/Proliferation, T-cells | N/A, Allergic contact dermatitis on challenge | Nov 29, 2016 | Dec 3, 2016 | |
3332 | Activation/Proliferation, T-cells | Activation of gluten- and TG2-reactive B cells | Aug 13, 2024 | Aug 13, 2024 | |
3334 | Activation/Proliferation, T-cells | Disruption of the intestinal barrier | Aug 13, 2024 | Aug 13, 2024 | |
3337 | Activation/Proliferation, T-cells | Formation of HLA-DQ2/8-gluten complexes | Aug 13, 2024 | Aug 13, 2024 | |
835 | Activation/Proliferation, T-cells | sensitisation, skin | Nov 29, 2016 | Dec 3, 2016 |
|
1701 | Activation/Proliferation, T-cells | Increase, Allergic Respiratory Hypersensitivity Response | Dec 7, 2017 | Aug 1, 2022 |
|
302 | Reduction, Testosterone synthesis by ovarian theca cells | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | Nov 29, 2016 | Mar 20, 2017 |
|
303 | Up Regulation, TGFbeta1 expression | Accumulation, Collagen | Nov 29, 2016 | Dec 3, 2016 | |
304 | Up Regulation, TGFbeta1 expression | Activation, Stellate cells | Nov 29, 2016 | Nov 29, 2016 | |
305 | TH synthesis, Decreased | T4 in serum, Decreased | Nov 29, 2016 | Oct 10, 2022 |
|
1504 | TH synthesis, Decreased | BDNF, Reduced | May 10, 2017 | Apr 4, 2019 |
|
1505 | TH synthesis, Decreased | GABAergic interneurons, Decreased | May 10, 2017 | May 29, 2018 |
|
1506 | TH synthesis, Decreased | Impairment, Learning and memory | May 10, 2017 | May 29, 2018 |
|
1768 | TH synthesis, Decreased | Reduction, Plasma 17beta-estradiol concentrations | Sep 18, 2018 | Sep 18, 2018 |
|
810 | TH synthesis, Decreased | Increased, Serum creatinine | Nov 29, 2016 | Dec 3, 2016 |
|
790 | Thyroperoxidase, Inhibition | Decrease, Incorporation of active iodide into iodotyrosines | Nov 29, 2016 | Dec 3, 2016 | |
1040 | Thyroperoxidase, Inhibition | Reduced, Anterior swim bladder inflation | Nov 29, 2016 | Feb 22, 2019 | |
309 | Thyroperoxidase, Inhibition | TH synthesis, Decreased | Nov 29, 2016 | Nov 4, 2022 |
|
383 | Thyroperoxidase, Inhibition | Cognitive function, decreased | Nov 29, 2016 | Dec 3, 2016 | |
366 | Thyroperoxidase, Inhibition | T4 in serum, Decreased | Nov 29, 2016 | Jul 8, 2022 |
|
444 | T4 in neuronal tissue, Decreased | BDNF, Reduced | Nov 29, 2016 | Apr 4, 2019 |
|
746 | T4 in neuronal tissue, Decreased | Hippocampal gene expression, Altered | Nov 29, 2016 | Aug 11, 2018 |
|
403 | T4 in serum, Decreased | Cognitive function, decreased | Nov 29, 2016 | Aug 11, 2018 |
|
312 | T4 in serum, Decreased | T4 in neuronal tissue, Decreased | Nov 29, 2016 | Apr 4, 2019 |
|
1039 | T4 in serum, Decreased | Reduced, Anterior swim bladder inflation | Nov 29, 2016 | Oct 10, 2022 |
|
1387 | T4 in serum, Decreased | Hippocampal gene expression, Altered | Mar 24, 2017 | Aug 11, 2018 |
|
1388 | T4 in serum, Decreased | Hippocampal anatomy, Altered | Mar 24, 2017 | Aug 11, 2018 |
|
1389 | T4 in serum, Decreased | Hippocampal Physiology, Altered | Mar 24, 2017 | Aug 11, 2018 |
|
1143 | T4 in serum, Decreased | Decreased, Thyroxine (T4) in tissues | Nov 29, 2016 | Sep 3, 2020 | |
2038 | T4 in serum, Decreased | Decreased, Triiodothyronine (T3) | Feb 19, 2020 | Oct 10, 2022 |
|
2865 | T4 in serum, Decreased | Insulin resistance, increased | Apr 3, 2023 | Apr 20, 2023 |
|
2420 | T4 in serum, Decreased | Increase, Thyroid-stimulating hormone (TSH) | Jul 7, 2021 | Jul 7, 2021 | |
2422 | T4 in serum, Decreased | Increased, Thyroid-stimulating hormone (TSH) | Jul 7, 2021 | Jul 7, 2021 |
|
2168 | T4 in serum, Decreased | Altered, Amphibian metamorphosis | Aug 25, 2020 | Aug 25, 2020 |
|
2473 | T4 in serum, Decreased | Occurrence, Cytoplasmic vacuolization (Renal tubule) | Sep 9, 2021 | Sep 9, 2021 |
|
2474 | T4 in serum, Decreased | Occurrence, Cystic dilatation (renal tubule) | Sep 9, 2021 | Sep 9, 2021 |
|
2475 | T4 in serum, Decreased | Occurrence, Cytoplasmic vacuolization (podocyte) | Sep 9, 2021 | Sep 9, 2021 |
|
315 | Reduction, Vitellogenin synthesis in liver | Reduction, Plasma vitellogenin concentrations | Nov 29, 2016 | Mar 20, 2017 |
|
316 | Altered, Transcription of genes by the AR | Feminisation or incomplete development, Primary and accessory male sex organs | Nov 29, 2016 | Dec 3, 2016 |
|
317 | Altered, Transcription of genes by the AR | Alteration, Wnt pathway | Nov 29, 2016 | Dec 3, 2016 |
|
2132 | Altered, Transcription of genes by the AR | nipple retention, increased | May 11, 2020 | May 11, 2020 |
|
2127 | Altered, Transcription of genes by the AR | AGD, decreased | May 11, 2020 | May 11, 2020 |
|
2273 | Altered, Transcription of genes by the AR | Reduced granulosa cell proliferation | Jan 28, 2021 | Apr 20, 2022 |
|
2909 | Altered, Transcription of genes by the AR | Increase, Androgen receptor | May 11, 2023 | May 11, 2023 |
|
319 | Activation of specific nuclear receptors, Transcriptional change | Cholestasis, Pathology | Nov 29, 2016 | Dec 3, 2016 |
|
437 | Decrease, Translocator protein (TSPO) | Reduction, Cholesterol transport in mitochondria | Nov 29, 2016 | Dec 2, 2016 |
|
399 | Decrease, Translocator protein (TSPO) | Reduction, Testosterone synthesis in Leydig cells | Nov 29, 2016 | Dec 3, 2016 | |
3162 | Accumulation, Triglyceride | Mitochondrial dysfunction | Mar 13, 2024 | Mar 13, 2024 |
|
2265 | Accumulation, Triglyceride | Increased, Liver Steatosis | Jan 15, 2021 | Mar 27, 2024 |
|
324 | N/A, Unknown | Proliferation, Cell proliferation in the absence of cytotoxicity | Nov 29, 2016 | Dec 3, 2016 |
|
751 | N/A, Unknown | Increased, Kidney Failure | Nov 29, 2016 | Dec 3, 2016 |
|
2235 | Induction, Upregulation of glucuronyltransferase activity | Increase, Biliary excretion TH glucuronide | Dec 9, 2020 | Dec 9, 2020 | |
2428 | Induction, Upregulation of glucuronyltransferase activity | Increased, T4/T3 catabolism | Jul 7, 2021 | Jul 7, 2021 | |
2483 | Induction, Upregulation of glucuronyltransferase activity | T4 in serum, Decreased | Sep 14, 2021 | Sep 14, 2021 | |
2478 | Induction, Upregulation of glucuronyltransferase activity | Increased, Clearance of thyroxine from serum | Sep 10, 2021 | Sep 10, 2021 |
|
2884 | Induction, Upregulation of glucuronyltransferase activity | Increase, Glucuronidation of T4 | Apr 12, 2023 | Apr 12, 2023 | |
329 | Insufficiency, Vascular | Abnormal, Morphogenesis | Nov 29, 2016 | Dec 3, 2016 | |
1036 | Insufficiency, Vascular | Increased, Developmental Defects | Nov 29, 2016 | Jan 18, 2022 |
|
330 | Binding, VEGF-A | Decreased, VegfR2 | Nov 29, 2016 | Dec 3, 2016 | |
331 | Binding, VEGF-A | Inhibition, VegfR2 | Nov 29, 2016 | Dec 3, 2016 | |
332 | Production, VEGF-A | Binding, VEGF-A | Nov 29, 2016 | Dec 3, 2016 | |
333 | Production, VEGF-A | Decreased, VegfR2 | Nov 29, 2016 | Dec 3, 2016 | |
334 | Decreased, VegfR2 | Inhibition, VegfR2 | Nov 29, 2016 | Dec 3, 2016 | |
335 | Inhibition, VegfR2 | Reduction, Angiogenesis | Nov 29, 2016 | Jul 20, 2022 |
|
336 | Increase, Vitellogenin synthesis in liver | Increase, Plasma vitellogenin concentrations | Nov 29, 2016 | Jun 24, 2024 |
|
337 | Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development | Reduction, Cumulative fecundity and spawning | Nov 29, 2016 | Mar 20, 2017 |
|
3396 | Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development | Growth, reduction | Nov 16, 2024 | Nov 16, 2024 |
|
338 | Alteration, Wnt pathway | Feminisation or incomplete development, Primary and accessory male sex organs | Nov 29, 2016 | Dec 3, 2016 |
|
977 | Altered, Cardiovascular development/function | Increase, Pericardial edema | Nov 29, 2016 | Jun 9, 2017 | |
1567 | Altered, Cardiovascular development/function | Increase, Early Life Stage Mortality | Jun 9, 2017 | Mar 23, 2018 |
|
1352 | Altered, Cardiovascular development/function | Increase, Mortality | Feb 9, 2017 | Feb 9, 2017 | |
472 | Accumulation, Fatty acid | Accumulation, Triglyceride | Nov 29, 2016 | May 28, 2024 |
|
514 | Accumulation, Fatty acid | Increased, Triglyceride formation | Nov 29, 2016 | Dec 3, 2016 |
|
515 | Accumulation, Fatty acid | Increased, Liver Steatosis | Nov 29, 2016 | Dec 3, 2016 |
|
135 | Decrease, Fecundity | Decline, Population | Nov 29, 2016 | Dec 3, 2016 | |
2621 | Decrease, Fecundity | Decrease, Reproduction | Mar 28, 2022 | Mar 28, 2022 |
|
1886 | Decrease, Fecundity | Decrease, Population growth rate | Apr 22, 2019 | Apr 22, 2019 |
|
1472 | Decrease, Fertility | Decrease, Population growth rate | Apr 15, 2017 | Apr 15, 2017 | |
1644 | Impairment, Learning and memory | Decreased, locomotion | Aug 11, 2017 | Aug 11, 2017 |
|
2872 | Impairment, Learning and memory | decreased, IQ | Apr 4, 2023 | Apr 4, 2023 |
|
564 | Impairment, Learning and memory | Abnormal, Roll change within caste | Nov 29, 2016 | Dec 3, 2016 |
|
583 | Impairment, Learning and memory | Abnormal, Foraging activity and behavior | Nov 29, 2016 | Dec 3, 2016 |
|
2889 | N/A, Liver Steatosis | Cell injury/death | Apr 13, 2023 | Apr 13, 2023 | |
405 | Malformation, Male reproductive tract | impaired, Fertility | Nov 29, 2016 | Dec 2, 2016 |
|
199 | Increase, Mortality | Decline, Population | Nov 29, 2016 | Dec 3, 2016 | |
198 | Increase, Mortality | Decrease, Fecundity | Nov 29, 2016 | Dec 3, 2016 | |
2463 | Increase, Mortality | Decrease, Population growth rate | Aug 5, 2021 | Aug 5, 2021 | |
1004 | Increase, Mortality | Decreased, population 1 | Nov 29, 2016 | Dec 3, 2016 | |
1013 | Increase, Mortality | Decreased, Population size | Nov 29, 2016 | Dec 3, 2016 | |
756 | Increased Mortality | Decreased, population 1 | Nov 29, 2016 | Dec 3, 2016 |
|
200 | Increased Mortality | Decline, Population | Nov 29, 2016 | Dec 3, 2016 | |
428 | Increased Mortality | Decreased, Population trajectory | Nov 29, 2016 | Dec 20, 2019 | |
1191 | Increased Mortality | Decreased, Population size | Nov 29, 2016 | Dec 3, 2016 | |
2486 | Increased Mortality | Decline, Population trajectory | Oct 8, 2021 | Oct 8, 2021 | |
2013 | Increased Mortality | Decrease, Population growth rate | Dec 20, 2019 | Jul 8, 2022 |
|
368 | N/A, Neurodegeneration | Neuronal network function, Decreased | Nov 29, 2016 | Dec 3, 2016 | |
207 | N/A, Neurodegeneration | Neuroinflammation | Nov 29, 2016 | Jun 13, 2018 |
|
3070 | N/A, Neurodegeneration | Overactivation, NMDARs | Oct 17, 2023 | Oct 17, 2023 |
|
3075 | N/A, Neurodegeneration | impaired, Learning and memory | Oct 17, 2023 | Oct 17, 2023 |
|
3081 | N/A, Neurodegeneration | Increase, seizure | Oct 17, 2023 | Oct 17, 2023 |
|
647 | N/A, Neurodegeneration | Decreased, Neuronal network function in adult brain | Nov 29, 2016 | Nov 29, 2016 |
|
2287 | N/A, Neurodegeneration | Encephalitis | Feb 23, 2021 | Feb 23, 2021 |
|
1069 | N/A, Neurodegeneration | Impairment, Learning and memory | Nov 29, 2016 | Apr 11, 2024 |
|
1265 | Decline, Population | Alteration, Food-web structures | Nov 29, 2016 | Dec 3, 2016 |
|
3260 | Impaired development of, Reproductive organs | Reduction, Cumulative fecundity and spawning | Jul 3, 2024 | Jul 3, 2024 |
|
296 | Increased, Structural malformations | Increased, Lethality | Nov 29, 2016 | Dec 3, 2016 | |
344 | Formation, Pro-mutagenic DNA Adducts | Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H | Nov 29, 2016 | Dec 3, 2016 | |
345 | Formation, Pro-mutagenic DNA Adducts | Tumorigenesis, Hepatocellular carcinoma | Nov 29, 2016 | Nov 29, 2016 |
|
352 | Formation, Pro-mutagenic DNA Adducts | Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci | Nov 29, 2016 | Nov 29, 2016 | |
548 | Formation, Pro-mutagenic DNA Adducts | Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts | Nov 29, 2016 | Dec 3, 2016 |
|
551 | Formation, Pro-mutagenic DNA Adducts | Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) | Nov 29, 2016 | Nov 29, 2016 |
|
549 | Increased, Induced Mutations in Critical Genes | Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) | Nov 29, 2016 | Nov 29, 2016 |
|
891 | Increased, Induced Mutations in Critical Genes | Increase, Site of Contact Nasal Tumors | Nov 29, 2016 | Dec 3, 2016 | |
342 | Increased, Induced Mutations in Critical Genes | Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H | Nov 29, 2016 | Nov 29, 2016 | |
346 | Increased, Induced Mutations in Critical Genes | Tumorigenesis, Hepatocellular carcinoma | Nov 29, 2016 | Nov 30, 2016 |
|
351 | Increased, Induced Mutations in Critical Genes | Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci | Nov 29, 2016 | Nov 29, 2016 | |
343 | Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H | Tumorigenesis, Hepatocellular carcinoma | Nov 29, 2016 | Nov 29, 2016 | |
340 | Activation, Pre-MIE: Metabolism of AFB1 | Formation, Pro-mutagenic DNA Adducts | Nov 29, 2016 | Dec 3, 2016 | |
348 | BDNF, Reduced | Aberrant, Dendritic morphology | Nov 29, 2016 | Nov 29, 2016 |
|
354 | BDNF, Reduced | Reduced, Presynaptic release of glutamate | Nov 29, 2016 | Nov 29, 2016 |
|
353 | BDNF, Reduced | Cell injury/death | Nov 29, 2016 | Nov 29, 2016 |
|
445 | BDNF, Reduced | Down Regulation, K-Cl co-transporter 2 (KCC2) | Nov 29, 2016 | Dec 3, 2016 | |
448 | BDNF, Reduced | Synaptogenesis, Decreased | Nov 29, 2016 | Apr 4, 2019 |
|
870 | BDNF, Reduced | GABAergic interneurons, Decreased | Nov 29, 2016 | Jan 19, 2018 |
|
1507 | BDNF, Reduced | Impairment, Learning and memory | May 10, 2017 | May 29, 2018 |
|
356 | Aberrant, Dendritic morphology | Synaptogenesis, Decreased | Nov 29, 2016 | Nov 29, 2016 |
|
357 | Reduced, Presynaptic release of glutamate | Synaptogenesis, Decreased | Nov 29, 2016 | Nov 29, 2016 |
|
350 | Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci | Tumorigenesis, Hepatocellular carcinoma | Nov 29, 2016 | Dec 3, 2016 | |
358 | Synaptogenesis, Decreased | Neuronal network function, Decreased | Nov 29, 2016 | May 25, 2018 |
|
656 | Synaptogenesis, Decreased | Neuroinflammation | Nov 29, 2016 | Dec 3, 2016 | |
359 | Neuronal network function, Decreased | Impairment, Learning and memory | Nov 29, 2016 | Jul 15, 2022 |
|
3123 | Neuronal network function, Decreased | autism-like behavior | Jan 25, 2024 | Jan 25, 2024 |
|
2953 | Neuronal network function, Decreased | Neurological disorder | Jun 21, 2023 | Jun 21, 2023 |
|
2411 | Neuronal network function, Decreased | Cognitive function, decreased | Jun 24, 2021 | Aug 27, 2021 |
|
2501 | Neuronal network function, Decreased | Memory Loss | Oct 26, 2021 | Oct 26, 2021 |
|
360 | Binding of agonist, NMDARs | Overactivation, NMDARs | Nov 29, 2016 | Nov 29, 2016 | |
361 | Overactivation, NMDARs | Increased, Intracellular Calcium overload | Nov 29, 2016 | Sep 10, 2023 |
|
2781 | Overactivation, NMDARs | Status epilepticus | Oct 12, 2022 | Sep 3, 2023 |
|
2806 | Overactivation, NMDARs | Loss of drebrin | Dec 11, 2022 | Jul 17, 2024 |
|
3038 | Overactivation, NMDARs | Increase, Cell membrane depolarization | Sep 14, 2023 | Sep 14, 2023 |
|
3068 | Overactivation, NMDARs | AchE Inhibition | Oct 17, 2023 | Oct 17, 2023 |
|
3069 | Overactivation, NMDARs | Decreased, Neuronal network function in adult brain | Oct 17, 2023 | Oct 17, 2023 |
|
3071 | Overactivation, NMDARs | Neuroinflammation | Oct 17, 2023 | Oct 17, 2023 |
|
3042 | Increased, Intracellular Calcium overload | Mitochondrial dysfunction EMPTY | Sep 14, 2023 | Sep 14, 2023 | |
3091 | Increased, Intracellular Calcium overload | Loss of drebrin | Oct 18, 2023 | Oct 18, 2023 |
|
3248 | Increased, Intracellular Calcium overload | Oxidative Stress | Jun 19, 2024 | Jun 19, 2024 |
|
3256 | Increased, Intracellular Calcium overload | Disruption, neurotransmitter release | Jun 19, 2024 | Jun 19, 2024 |
|
3426 | Increased, Intracellular Calcium overload | Decrease, Cardiac contractility | Nov 21, 2024 | Nov 21, 2024 |
|
2140 | Increased, Intracellular Calcium overload | Status epilepticus | May 21, 2020 | May 21, 2020 | |
1862 | Increased, Intracellular Calcium overload | Cell injury/death | Feb 19, 2019 | Sep 3, 2023 |
|
1860 | Increased, Intracellular Calcium overload | Occurrence, Epileptic seizure | Feb 13, 2019 | Feb 13, 2019 | |
892 | Increased, Intracellular Calcium overload | Decreased, Neuronal network function in adult brain | Nov 29, 2016 | Dec 3, 2016 | |
2710 | Increased, Intracellular Calcium overload | Endoplasmic reticulum stress | Jul 25, 2022 | Jul 25, 2022 |
|
2709 | Increased, Intracellular Calcium overload | Decrease, OXPHOS | Jul 25, 2022 | Jul 25, 2022 | |
2704 | Increased, Intracellular Calcium overload | Activation, calpain | Jul 25, 2022 | Jul 25, 2022 |
|
362 | Increased, Intracellular Calcium overload | Mitochondrial dysfunction | Nov 29, 2016 | Nov 29, 2016 |
|
377 | Covalent Binding, Protein | Activation, Dendritic Cells | Nov 29, 2016 | Nov 5, 2020 |
|
376 | Covalent Binding, Protein | Response, Keratinocytes | Nov 29, 2016 | Dec 3, 2016 | |
2650 | Covalent Binding, Protein | Increase, Allergic Respiratory Hypersensitivity Response | Apr 28, 2022 | Aug 1, 2022 |
|
2649 | Covalent Binding, Protein | Increased proinflammatory mediators | Apr 28, 2022 | Sep 8, 2022 |
|
2202 | Covalent Binding, Protein | Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways | Nov 5, 2020 | Feb 11, 2021 | |
833 | Covalent Binding, Protein | Activation, Keratinocytes | Nov 29, 2016 | Dec 3, 2016 |
|
380 | Response, Keratinocytes | Activation/Proliferation, T-cells | Nov 29, 2016 | Dec 3, 2016 | |
378 | Response, Keratinocytes | Activation, Dendritic Cells | Nov 29, 2016 | Nov 29, 2016 | |
379 | Activation, Dendritic Cells | Activation/Proliferation, T-cells | Nov 29, 2016 | Aug 22, 2022 |
|
2236 | Increase, Biliary excretion TH glucuronide | T4 in serum, Decreased | Dec 9, 2020 | Dec 9, 2020 | |
570 | Suppression, Immune system | Increased, Viral susceptibility | Nov 29, 2016 | Dec 3, 2016 |
|
394 | irregularities, ovarian cycle | impaired, Fertility | Nov 29, 2016 | Dec 3, 2016 |
|
393 | irregularities, ovarian cycle | Decrease, Fertility | Nov 29, 2016 | Dec 3, 2016 | |
2387 | impaired, Fertility | Decrease of egg production and cummulative fecundity | May 12, 2021 | May 12, 2021 |
|
2292 | impaired, Fertility | Decrease, Population growth rate | Mar 26, 2021 | Mar 26, 2021 |
|
396 | reduction in ovarian granulosa cells, Aromatase (Cyp19a1) | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | Nov 29, 2016 | Nov 29, 2016 |
|
402 | Metabolism of AFB1, Production of Reactive Electrophiles | Formation, Pro-mutagenic DNA Adducts | Nov 29, 2016 | Nov 29, 2016 |
|
439 | Reduction, Testosterone synthesis in Leydig cells | Reduction of testosterone | Nov 29, 2016 | Dec 2, 2016 | |
2125 | Reduction, Testosterone synthesis in Leydig cells | Decrease, circulating testosterone levels | May 11, 2020 | May 1, 2024 |
|
461 | Increase, Luteinizing hormone (LH) | Increase proliferation, Leydig cell | Nov 29, 2016 | Dec 3, 2016 |
|
462 | Hyperplasia, Leydig cell | impaired, Fertility | Nov 29, 2016 | Dec 3, 2016 |
|
398 | Increase proliferation, Leydig cell | Hyperplasia, Leydig cell | Nov 29, 2016 | Dec 3, 2016 |
|
442 | Inhibition, Na+/I- symporter (NIS) | Thyroidal Iodide, Decreased | Nov 29, 2016 | May 29, 2018 |
|
552 | Inhibition, Na+/I- symporter (NIS) | TH synthesis, Decreased | Nov 29, 2016 | Dec 3, 2016 |
|
1503 | Inhibition, Na+/I- symporter (NIS) | Impairment, Learning and memory | May 10, 2017 | Apr 4, 2019 |
|
2232 | Inhibition, Na+/I- symporter (NIS) | T4 in serum, Decreased | Dec 9, 2020 | Dec 9, 2020 |
|
872 | Thyroidal Iodide, Decreased | TH synthesis, Decreased | Nov 29, 2016 | Jun 4, 2018 |
|
443 | Thyroidal Iodide, Decreased | T4 in serum, Decreased | Nov 29, 2016 | Nov 29, 2016 | |
446 | Down Regulation, K-Cl co-transporter 2 (KCC2) | Delay, Developmental GABA shift | Nov 29, 2016 | Dec 3, 2016 | |
447 | Delay, Developmental GABA shift | Synaptogenesis, Decreased | Nov 29, 2016 | Dec 3, 2016 | |
1491 | Decreased, Population trajectory | Increased Mortality | Apr 18, 2017 | Apr 18, 2017 | |
591 | Increased, Atrioventricular block and bradycardia | Respiratory distress/arrest | Nov 29, 2016 | Dec 3, 2016 |
|
432 | Increased, Atrioventricular block and bradycardia | Increased Mortality | Nov 29, 2016 | Nov 29, 2016 | |
433 | Respiratory distress/arrest | Increased Mortality | Nov 29, 2016 | Dec 20, 2019 |
|
592 | Respiratory distress/arrest | N/A, hypoxia | Nov 29, 2016 | Dec 3, 2016 |
|
460 | Reduction of testosterone | Increase, Luteinizing hormone (LH) | Nov 29, 2016 | Dec 3, 2016 | |
608 | Reduction of testosterone | Malformation, Male reproductive tract | Nov 29, 2016 | Dec 2, 2016 | |
1649 | Reduction of testosterone | Decreased sperm quantity or quality in the adult, Decreased fertility | Aug 11, 2017 | Aug 11, 2017 | |
438 | Reduction, Cholesterol transport in mitochondria | Reduction, Testosterone synthesis in Leydig cells | Nov 29, 2016 | Dec 2, 2016 |
|
3216 | Suppression, VLDL secretion | Increased, Liver Steatosis | May 9, 2024 | May 9, 2024 |
|
475 | Inhibition, Mitochondrial fatty acid beta-oxidation | Accumulation, Fatty acid | Nov 29, 2016 | Dec 3, 2016 |
|
538 | Inhibition, Mitochondrial fatty acid beta-oxidation | Increased, Liver Steatosis | Nov 29, 2016 | Dec 3, 2016 |
|
486 | Increased, Triglyceride formation | Increased, Liver Steatosis | Nov 29, 2016 | Dec 3, 2016 |
|
476 | Suppression, Constitutive androstane receptor, NR1l3 | Activation, LXR | Nov 29, 2016 | Dec 3, 2016 |
|
477 | Suppression, Constitutive androstane receptor, NR1l3 | demethylation, PPARg promoter | Nov 29, 2016 | Dec 3, 2016 |
|
482 | Activation, SREBF1 | Increased, De Novo FA synthesis | Nov 29, 2016 | Dec 3, 2016 | |
489 | Activation, SREBF1 | Up Regulation, SCD-1 | Nov 29, 2016 | Dec 3, 2016 |
|
1662 | Activation, SREBF1 | Increased, Liver Steatosis | Aug 31, 2017 | Aug 31, 2017 |
|
1607 | Increased, De Novo FA synthesis | Increased, Liver Steatosis | Jul 18, 2017 | Jul 18, 2017 |
|
484 | Increased, De Novo FA synthesis | Increased, Triglyceride formation | Nov 29, 2016 | Dec 3, 2016 | |
512 | Increased, De Novo FA synthesis | Accumulation, Fatty acid | Nov 29, 2016 | Dec 3, 2016 |
|
3218 | Increased, Liver Steatosis | Cell injury/death | May 14, 2024 | May 14, 2024 |
|
1695 | Increased, Liver Steatosis | Increased, Reactive oxygen species | Nov 14, 2017 | Nov 14, 2017 |
|
2263 | Increased, Fatty acid uptake | Increased, Liver Steatosis | Jan 15, 2021 | Jan 15, 2021 | |
1657 | Up Regulation, SCD-1 | Accumulation, Triglyceride | Aug 31, 2017 | Aug 31, 2017 |
|
493 | Up Regulation, SCD-1 | Increased, Triglyceride formation | Nov 29, 2016 | Dec 3, 2016 |
|
492 | Up Regulation, FAS | Increased, De Novo FA synthesis | Nov 29, 2016 | Dec 3, 2016 |
|
504 | Increased, FA Influx | Accumulation, Triglyceride | Nov 29, 2016 | Dec 3, 2016 | |
505 | Increased, FA Influx | Accumulation, Fatty acid | Nov 29, 2016 | Dec 3, 2016 |
|
1658 | Increased, FA Influx | Increased, Triglyceride formation | Aug 31, 2017 | Aug 31, 2017 |
|
507 | Up Regulation, LDLR (low density lipoprotein receptor) | Increased, LDL uptake | Nov 29, 2016 | Dec 3, 2016 |
|
508 | Increased, LDL uptake | Accumulation, Fatty acid | Nov 29, 2016 | Dec 3, 2016 |
|
3443 | Increased, LDL uptake | Foam cell formation | Nov 25, 2024 | Nov 25, 2024 |
|
511 | Inhibition, PPAR alpha | Inhibition, Mitochondrial fatty acid beta-oxidation | Nov 29, 2016 | Dec 3, 2016 |
|
517 | Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) | Increased, De Novo FA synthesis | Nov 29, 2016 | Dec 3, 2016 |
|
519 | Inhibition, FoxA2 | Down Regulation, CPT1A | Nov 29, 2016 | Dec 3, 2016 |
|
523 | Inhibition, FoxA2 | Down Regulation, HMGCS2 | Nov 29, 2016 | Dec 3, 2016 |
|
520 | Down Regulation, CPT1A | Decreased, Mitochondrial fatty acid beta-oxidation | Nov 29, 2016 | Dec 3, 2016 |
|
524 | Down Regulation, HMGCS2 | Decreased, Ketogenesis | Nov 29, 2016 | Dec 3, 2016 |
|
1660 | Decreased, Ketogenesis | Accumulation, Fatty acid | Aug 31, 2017 | Aug 31, 2017 |
|
1406 | Activation, NRF2 | Activation, FXR | Apr 12, 2017 | Apr 12, 2017 | |
532 | Activation, NRF2 | Activation, NR1H4 | Nov 29, 2016 | Dec 3, 2016 |
|
533 | Activation, NR1H4 | Activation, SHP | Nov 29, 2016 | Dec 3, 2016 |
|
534 | Activation, NR1H4 | Activation, PPARα | Nov 29, 2016 | Dec 3, 2016 |
|
896 | Activation, SHP | Inhibition, SREBP1c | Nov 29, 2016 | Dec 3, 2016 |
|
1409 | Activation, SHP | Activation, PPARα | Apr 12, 2017 | Apr 12, 2017 | |
1412 | Activation, SHP | Inhibition, LXR | Apr 12, 2017 | Apr 12, 2017 | |
1414 | Activation, SHP | Inhibition, LRH-1 | Apr 12, 2017 | Apr 12, 2017 | |
537 | Decreased, DHB4/HSD17B4 | Inhibition, Mitochondrial fatty acid beta-oxidation | Nov 29, 2016 | Dec 3, 2016 |
|
1606 | Activation, LXR alpha | Increased, De Novo FA synthesis | Jul 18, 2017 | Jul 18, 2017 |
|
1661 | Activation, AKT2 | Activation, SREBF1 | Aug 31, 2017 | Aug 31, 2017 |
|
541 | inflammation | Activation, AKT2 | Nov 29, 2016 | Dec 3, 2016 |
|
544 | Decrease, Ovulation | Reduction, Cumulative fecundity and spawning | Nov 29, 2016 | Dec 3, 2016 | |
687 | Decrease, Ovulation | Reduced, Reproductive Success | Nov 29, 2016 | Dec 3, 2016 |
|
1471 | Decrease, Ovulation | Decrease, Fertility | Apr 15, 2017 | Apr 15, 2017 | |
1753 | Decrease, Ovulation | Decrease, Fecundity | Jun 12, 2018 | Jun 12, 2018 | |
550 | Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) | Tumorigenesis, Hepatocellular carcinoma | Nov 29, 2016 | Nov 29, 2016 |
|
547 | Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts | Increased, Induced Mutations in Critical Genes | Nov 29, 2016 | Nov 29, 2016 |
|
1645 | GR Agonist, Activation | Decreased Leydig Cells | Aug 11, 2017 | Aug 11, 2017 |
|
1646 | GR Agonist, Activation | Repressed expression of steroidogenic enzymes | Aug 11, 2017 | Aug 11, 2017 |
|
1648 | Repressed expression of steroidogenic enzymes | Reduction, Testosterone synthesis in Leydig cells | Aug 11, 2017 | Aug 11, 2017 |
|
1647 | Decreased Leydig Cells | Reduction, Testosterone synthesis in Leydig cells | Aug 11, 2017 | Aug 11, 2017 |
|
1650 | Decreased sperm quantity or quality in the adult, Decreased fertility | impaired, Fertility | Aug 11, 2017 | Aug 11, 2017 |
|
1146 | Activation, Nicotinic acetylcholine receptor | Impairment, Learning and memory | Nov 29, 2016 | Dec 3, 2016 |
|
1147 | Activation, Nicotinic acetylcholine receptor | Abnormal, Foraging activity and behavior | Nov 29, 2016 | Dec 3, 2016 | |
581 | Activation, Nicotinic acetylcholine receptor | Mitochondrial dysfunction | Nov 29, 2016 | Dec 3, 2016 |
|
658 | Activation, Nicotinic acetylcholine receptor | Desensitization, Nicotinic acetylcholine receptor | Nov 29, 2016 | Jun 7, 2018 |
|
569 | Abnormal, Foraging activity and behavior | Decrease, Number of worker bees | Nov 29, 2016 | Dec 3, 2016 |
|
584 | Abnormal, Foraging activity and behavior | Reduced, Food storage | Nov 29, 2016 | Dec 3, 2016 | |
1144 | Abnormal, Foraging activity and behavior | Weakened, Colony | Nov 29, 2016 | Dec 3, 2016 |
|
1148 | Abnormal, Foraging activity and behavior | Abnormal, Roll change within caste | Nov 29, 2016 | Dec 3, 2016 | |
1150 | Abnormal, Foraging activity and behavior | Abnormal, Role change within caste | Nov 29, 2016 | Dec 3, 2016 |
|
558 | Reduced, Food storage | Decrease, Number of worker bees | Nov 29, 2016 | Dec 3, 2016 | |
562 | Reduced, Food storage | impaired, Larval development | Nov 29, 2016 | Dec 3, 2016 |
|
565 | Abnormal, Roll change within caste | Reduced, Brood care | Nov 29, 2016 | Dec 3, 2016 |
|
579 | Abnormal, Roll change within caste | Reduced, Food storage | Nov 29, 2016 | Dec 3, 2016 |
|
580 | Abnormal, Roll change within caste | Decrease, Number of worker bees | Nov 29, 2016 | Dec 3, 2016 | |
1149 | Abnormal, Roll change within caste | Weakened, Colony | Nov 29, 2016 | Dec 3, 2016 | |
566 | Reduced, Brood care | impaired, Larval development | Nov 29, 2016 | Dec 3, 2016 |
|
563 | impaired, Larval development | Death/Failure, Colony | Nov 29, 2016 | Dec 3, 2016 |
|
574 | impaired, Hive thermoregulation | Death/Failure, Colony | Nov 29, 2016 | Dec 3, 2016 |
|
1153 | impaired, Hive thermoregulation | Weakened, Colony | Nov 29, 2016 | Dec 3, 2016 |
|
662 | Accumulation, Damaged mitochondrial DNA | Accelerated, Aging | Nov 29, 2016 | Dec 3, 2016 |
|
663 | Accelerated, Aging | Decrease, Number of worker bees | Nov 29, 2016 | Dec 3, 2016 |
|
559 | Decrease, Number of worker bees | Death/Failure, Colony | Nov 29, 2016 | Dec 3, 2016 |
|
573 | Decrease, Number of worker bees | impaired, Hive thermoregulation | Nov 29, 2016 | Dec 3, 2016 |
|
567 | Increase, Energetic demands and therefore metabolic stress | Increased, Appetite and hunger | Nov 29, 2016 | Dec 3, 2016 |
|
568 | Increased, Appetite and hunger | Abnormal, Foraging activity and behavior | Nov 29, 2016 | Dec 3, 2016 |
|
571 | Increased, Viral susceptibility | impaired, Development | Nov 29, 2016 | Dec 3, 2016 |
|
575 | Increased, Viral susceptibility | Abnormal, Foraging activity and behavior | Nov 29, 2016 | Dec 3, 2016 |
|
572 | impaired, Development | Decrease, Number of worker bees | Nov 29, 2016 | Dec 3, 2016 |
|
576 | Decreased, Glucose oxidase enzyme activity | Decreased, Hydrogen peroxide production | Nov 29, 2016 | Dec 3, 2016 |
|
577 | Decreased, Hydrogen peroxide production | Reduced, Antiseptic incorporated in food | Nov 29, 2016 | Dec 3, 2016 |
|
578 | Reduced, Antiseptic incorporated in food | Abnormal, Roll change within caste | Nov 29, 2016 | Dec 3, 2016 |
|
665 | impaired, Thoracic shivering | impaired, Hive thermoregulation | Nov 29, 2016 | Dec 3, 2016 | |
585 | Inhibition, sodium channel | Decreased, Sodium conductance 1 | Nov 29, 2016 | Dec 3, 2016 |
|
590 | Inhibition, sodium channel | Increased, Atrioventricular block and bradycardia | Nov 29, 2016 | Dec 3, 2016 | |
1242 | Inhibition, sodium channel | Decreased, sodium conductance 2 | Nov 29, 2016 | Dec 3, 2016 |
|
3414 | Inhibition, sodium channel | Altered, Action Potential | Nov 21, 2024 | Nov 21, 2024 |
|
586 | Decreased, Sodium conductance 1 | Reduced, swimming speed | Nov 29, 2016 | Dec 3, 2016 |
|
594 | Decreased, Sodium conductance 1 | Increased, Atrioventricular block and bradycardia | Nov 29, 2016 | Dec 3, 2016 |
|
587 | Reduced, swimming speed | Reduced, feeding 1 | Nov 29, 2016 | Dec 3, 2016 |
|
588 | Reduced, swimming speed | Increased, predation | Nov 29, 2016 | Dec 3, 2016 |
|
589 | Reduced, feeding 1 | Increased, predation | Nov 29, 2016 | Dec 3, 2016 |
|
596 | Reduced, feeding 1 | Reduced, survival | Nov 29, 2016 | Dec 3, 2016 |
|
595 | Increased, predation | Reduced, survival | Nov 29, 2016 | Dec 3, 2016 |
|
654 | Increased, predation | Decreased, survival | Nov 29, 2016 | Dec 3, 2016 |
|
593 | N/A, hypoxia | Increased, amputations | Nov 29, 2016 | Dec 3, 2016 |
|
3307 | N/A, hypoxia | Increase, angiogenesis | Jul 18, 2024 | Jul 18, 2024 | |
3370 | N/A, hypoxia | Increase, Cancer | Oct 25, 2024 | Oct 25, 2024 |
|
3419 | Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel | Prolongation of Action Potential | Nov 21, 2024 | Nov 21, 2024 |
|
597 | Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel | Decreased, Sodium conductance 1 | Nov 29, 2016 | Dec 3, 2016 |
|
603 | modulation, sodium channel | prolonged, Depolarization of neuronal membrane | Nov 29, 2016 | Dec 3, 2016 |
|
604 | prolonged, Depolarization of neuronal membrane | Overactivation, Neuronotransmitter release | Nov 29, 2016 | Dec 3, 2016 |
|
605 | Overactivation, Neuronotransmitter release | Overactivation, muscle contraction | Nov 29, 2016 | Dec 3, 2016 |
|
606 | Overactivation, muscle contraction | Increased, Ataxia, paralysis, or hyperactivity | Nov 29, 2016 | Dec 3, 2016 |
|
607 | Increased, Ataxia, paralysis, or hyperactivity | Increased Mortality | Nov 29, 2016 | Dec 3, 2016 |
|
1861 | Occurrence, Epileptic seizure | Increased, glutamate | Feb 13, 2019 | Feb 13, 2019 | |
1999 | Occurrence, Epileptic seizure | Overactivation, NMDARs | Nov 13, 2019 | Nov 13, 2019 | |
630 | Occurrence, A paroxysmal depolarizing shift | Occurrence, Epileptic seizure | Nov 29, 2016 | May 22, 2018 |
|
634 | Decreased, Neuronal network function in adult brain | Impairment, Learning and memory | Nov 29, 2016 | Nov 29, 2016 |
|
3072 | Decreased, Neuronal network function in adult brain | Neurological disorder | Oct 17, 2023 | Oct 17, 2023 |
|
3073 | Decreased, Neuronal network function in adult brain | Neuroinflammation | Oct 17, 2023 | Oct 17, 2023 |
|
3074 | Decreased, Neuronal network function in adult brain | Degeneration of dopaminergic neurons of the nigrostriatal pathway | Oct 17, 2023 | Oct 17, 2023 | |
3076 | Decreased, Neuronal network function in adult brain | impaired, Learning and memory | Oct 17, 2023 | Oct 17, 2023 |
|
2656 | Decreased, Neuronal network function in adult brain | Sensory axonal peripheral neuropathy | May 16, 2022 | May 16, 2022 |
|
635 | Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) | Increased, serotonin (5-HT) 1 | Nov 29, 2016 | Dec 3, 2016 | |
643 | Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) | Increased, serotonin (5-HT) | Nov 29, 2016 | Dec 3, 2016 |
|
1208 | Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) | Increased, cilia movement | Nov 29, 2016 | Dec 3, 2016 | |
1316 | Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) | Increased, muscular waves in foot | Jan 13, 2017 | Jan 13, 2017 |
|
1317 | Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) | Increased, valve movement | Jan 13, 2017 | Jan 13, 2017 |
|
1318 | Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) | Increase, cilia movement | Jan 13, 2017 | Jan 13, 2017 |
|
1319 | Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) | increased mantel display | Jan 13, 2017 | Jan 13, 2017 |
|
1337 | Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) | Increased, oocyte maturation | Jan 30, 2017 | Jan 30, 2017 |
|
1172 | Increased, serotonin (5-HT) 1 | Increased, valve movement | Nov 29, 2016 | Dec 3, 2016 | |
1186 | Increased, serotonin (5-HT) 1 | Decreased, gametogenesis | Nov 29, 2016 | Dec 3, 2016 | |
1189 | Increased, serotonin (5-HT) 1 | Increased, locomotion | Nov 29, 2016 | Dec 3, 2016 | |
1192 | Increased, serotonin (5-HT) 1 | increased or inappropriate, mantel display | Nov 29, 2016 | Dec 3, 2016 | |
636 | Increased, serotonin (5-HT) 1 | Increase, cilia movement | Nov 29, 2016 | Dec 3, 2016 | |
640 | Increased, serotonin (5-HT) 1 | Increased, muscular waves in foot | Nov 29, 2016 | Dec 3, 2016 | |
637 | Increase, cilia movement | Increased, locomotion | Nov 29, 2016 | Dec 3, 2016 | |
639 | Increase, cilia movement | Increased, foot detachment | Nov 29, 2016 | Dec 3, 2016 | |
1178 | Increase, cilia movement | premature, spawning 1 | Nov 29, 2016 | Dec 3, 2016 | |
1187 | Increase, cilia movement | premature, Spawning | Nov 29, 2016 | Dec 3, 2016 | |
1217 | Increase, cilia movement | Increased, water pumping | Nov 29, 2016 | Dec 3, 2016 | |
1218 | Increase, cilia movement | Depletion, energy reserves | Nov 29, 2016 | Dec 3, 2016 | |
1321 | Increase, cilia movement | induced spawning | Jan 13, 2017 | Jan 13, 2017 |
|
1335 | Increase, cilia movement | Induced parturition | Jan 30, 2017 | Jan 30, 2017 |
|
1177 | Increased, locomotion | Depletion, energy reserves | Nov 29, 2016 | Dec 3, 2016 |
|
638 | Increased, locomotion | Increase, predation | Nov 29, 2016 | Dec 3, 2016 |
|
2634 | Increase, predation | Decrease, Population growth rate | Apr 6, 2022 | Apr 6, 2022 |
|
1176 | Increased, foot detachment | Depletion, energy reserves | Nov 29, 2016 | Dec 3, 2016 |
|
1183 | Increased, foot detachment | Increase, predation | Nov 29, 2016 | Dec 3, 2016 | |
1228 | Increased, muscular waves in foot | Depletion, energy reserves | Nov 29, 2016 | Dec 3, 2016 | |
641 | Increased, muscular waves in foot | Increased, locomotion | Nov 29, 2016 | Dec 3, 2016 |
|
642 | Increased, muscular waves in foot | Increased, foot detachment | Nov 29, 2016 | Dec 3, 2016 |
|
644 | Increased, serotonin (5-HT) | Decreased, anxiety | Nov 29, 2016 | Dec 3, 2016 |
|
1207 | Increased, serotonin (5-HT) | Increased, mantel display | Nov 29, 2016 | Dec 3, 2016 | |
1209 | Increased, serotonin (5-HT) | Increased, cilia movement | Nov 29, 2016 | Dec 3, 2016 | |
1212 | Increased, serotonin (5-HT) | Increased, oocyte maturation | Nov 29, 2016 | Dec 3, 2016 |
|
1327 | Increased, serotonin (5-HT) | Increased, valve movement | Jan 17, 2017 | Jan 17, 2017 |
|
1332 | Increased, serotonin (5-HT) | Increased, muscular waves in foot | Jan 30, 2017 | Jan 30, 2017 |
|
1333 | Increased, serotonin (5-HT) | Increase, cilia movement | Jan 30, 2017 | Jan 30, 2017 |
|
1336 | Increased, serotonin (5-HT) | increased mantel display | Jan 30, 2017 | Jan 30, 2017 |
|
645 | Decreased, anxiety | Decreased, sheltering | Nov 29, 2016 | Dec 3, 2016 |
|
646 | Decreased, sheltering | Increased, predation | Nov 29, 2016 | Dec 3, 2016 |
|
649 | Decrease, histaminergic neuron excitation | N/A, sedation | Nov 29, 2016 | Dec 3, 2016 |
|
1643 | Decrease, histaminergic neuron excitation | Impairment, Learning and memory | Aug 11, 2017 | Aug 11, 2017 |
|
650 | N/A, sedation | Decreased, locomotion | Nov 29, 2016 | Dec 3, 2016 |
|
651 | Decreased, locomotion | Increased, predation | Nov 29, 2016 | Dec 3, 2016 |
|
3079 | impaired, Learning and memory | Parkinsonian motor deficits | Oct 17, 2023 | Oct 17, 2023 |
|
1061 | Antagonism, Histamine Receptor (H2) | Decrease, histaminergic neuron excitation | Nov 29, 2016 | Dec 3, 2016 |
|
3168 | Decreased, steroidogenic protein expression | Decrease, circulating testosterone levels | Mar 20, 2024 | Dec 3, 2024 |
|
3171 | Decreased, steroidogenic protein expression | Decrease, DHT level | Mar 20, 2024 | Dec 3, 2024 |
|
3167 | Decreased COUP-TFII in Leydig cells | Decreased, steroidogenic protein expression | Mar 20, 2024 | Dec 3, 2024 |
|
1309 | Desensitization, Nicotinic acetylcholine receptor | Altered, Ca2+-calmodulin activated signal transduction | Nov 29, 2016 | Dec 3, 2016 |
|
659 | Desensitization, Nicotinic acetylcholine receptor | Neuronal network function, Decreased | Nov 29, 2016 | Dec 3, 2016 |
|
661 | Overwhelmed, Mitochondrial DNA repair mechanisms | Accumulation, Damaged mitochondrial DNA | Nov 29, 2016 | Dec 3, 2016 |
|
666 | Binding at picrotoxin site, iGABAR chloride channel | Reduction, Ionotropic GABA receptor chloride channel conductance | Nov 29, 2016 | Apr 29, 2019 |
|
683 | Reduction, Neuronal synaptic inhibition | Generation, Amplified excitatory postsynaptic potential (EPSP) | Nov 29, 2016 | May 15, 2018 |
|
672 | Reduced, Prostaglandin F2alpha concentration, plasma | Reduced, Spawning behavior | Nov 29, 2016 | Dec 3, 2016 |
|
678 | Reduced, Prostaglandin F2alpha concentration, plasma | Reduced, Pheromone release | Nov 29, 2016 | Dec 3, 2016 |
|
671 | Reduced, Prostaglandin F2alpha synthesis, ovary | Reduced, Prostaglandin F2alpha concentration, plasma | Nov 29, 2016 | Dec 3, 2016 |
|
673 | Reduced, Spawning behavior | Reduced, Ability to attract spawning mates | Nov 29, 2016 | Dec 3, 2016 |
|
674 | Reduced, Ability to attract spawning mates | Reduced, Reproductive Success | Nov 29, 2016 | Dec 3, 2016 |
|
675 | Reduced, Reproductive Success | Decrease, Population growth rate | Nov 29, 2016 | Dec 3, 2016 |
|
679 | Reduced, Pheromone release | Reduced, Ability to attract spawning mates | Nov 29, 2016 | Dec 3, 2016 |
|
682 | Decreased, Prostaglandin F2alpha synthesis, ovary | Reduced, Prostaglandin F2alpha concentration, plasma | Nov 29, 2016 | Dec 3, 2016 |
|
684 | Generation, Amplified excitatory postsynaptic potential (EPSP) | Occurrence, A paroxysmal depolarizing shift | Nov 29, 2016 | May 15, 2018 |
|
685 | Reduced, Prostaglandins, ovary | Decrease, Ovulation | Nov 29, 2016 | Dec 3, 2016 |
|
690 | Reduced, Prostaglandin E2 concentration, hypothalamus | Reduced, Gonadotropin releasing hormone, hypothalamus | Nov 29, 2016 | Dec 3, 2016 |
|
691 | Reduced, Gonadotropin releasing hormone, hypothalamus | Reduced, Luteinizing hormone (LH), plasma | Nov 29, 2016 | Dec 3, 2016 |
|
692 | Reduced, Luteinizing hormone (LH), plasma | Reduced, Maturation inducing steroid, plasma | Nov 29, 2016 | Dec 3, 2016 |
|
693 | Reduced, Maturation inducing steroid, plasma | Reduced, Maturation inducing steroid receptor signalling, oocyte | Nov 29, 2016 | Dec 3, 2016 |
|
694 | Reduced, Maturation inducing steroid receptor signalling, oocyte | Increased, cyclic adenosine monophosphate | Nov 29, 2016 | Dec 3, 2016 |
|
698 | Reduced, Maturation inducing steroid receptor signalling, oocyte | Upregulated, Spindle assembly checkpoint protein Mad2-oocyte | Nov 29, 2016 | Dec 3, 2016 |
|
695 | Increased, cyclic adenosine monophosphate | Reduced, Reproductive Success | Nov 29, 2016 | Dec 3, 2016 | |
696 | Increased, cyclic adenosine monophosphate | Reduced, Meiotic prophase I/metaphase I transition, oocyte | Nov 29, 2016 | Dec 3, 2016 |
|
3446 | Increased, cyclic adenosine monophosphate | RyR2 hyperphosphorylation | Nov 26, 2024 | Nov 26, 2024 |
|
697 | Reduced, Meiotic prophase I/metaphase I transition, oocyte | Reduced, Reproductive Success | Nov 29, 2016 | Dec 3, 2016 |
|
699 | Upregulated, Spindle assembly checkpoint protein Mad2-oocyte | Increased, Chromosome misseggregation | Nov 29, 2016 | Dec 3, 2016 |
|
700 | Increased, Chromosome misseggregation | Reduced, Reproductive Success | Nov 29, 2016 | Dec 3, 2016 |
|
701 | impaired, ion channels | Altered, Action Potential | Nov 29, 2016 | Dec 3, 2016 |
|
702 | Altered, Action Potential | Increased, cardiac arrthymia | Nov 29, 2016 | Dec 3, 2016 |
|
3407 | Altered, Action Potential | Prolongation of QT interval | Nov 20, 2024 | Nov 20, 2024 |
|
3432 | Altered, Action Potential | Prolonged atrioventricular (AV) | Nov 22, 2024 | Nov 22, 2024 |
|
3415 | Altered, Action Potential | Decrease, Cardiac contractility | Nov 21, 2024 | Nov 21, 2024 |
|
703 | Increased, cardiac arrthymia | Increased Mortality | Nov 29, 2016 | Dec 3, 2016 |
|
707 | Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) | Increase, Cytotoxicity (renal tubular cell) | Nov 29, 2016 | Dec 3, 2016 |
|
708 | Increase, Cytotoxicity (renal tubular cell) | Increase, Regenerative cell proliferation (tubular epithelial cells) | Nov 29, 2016 | Dec 3, 2016 |
|
1676 | Increase, Cytotoxicity (renal tubular cell) | Occurrence, Kidney toxicity | Oct 25, 2017 | Mar 8, 2022 |
|
760 | Increase, Regenerative cell proliferation (tubular epithelial cells) | Increase, Hyperplasia (renal tubular cells) | Nov 29, 2016 | Dec 3, 2016 |
|
785 | Increase, Regenerative cell proliferation (tubular epithelial cells) | Increase, Hyperplasia (tubular epithelial cells) | Nov 29, 2016 | Dec 3, 2016 |
|
706 | Increased, Binding of chemicals to 2u (serum) | Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) | Nov 29, 2016 | Dec 3, 2016 |
|
711 | Activation, Constitutive androstane receptor | Increase, cell proliferation (hepatocytes) | Nov 29, 2016 | Dec 3, 2016 | |
1268 | Activation, Constitutive androstane receptor | Altered expression of hepatic CAR-dependent genes | Nov 29, 2016 | Dec 21, 2018 |
|
1239 | Increase, cell proliferation (hepatocytes) | Increase, Clonal Expansion of Altered Hepatic Foci | Nov 29, 2016 | Dec 3, 2016 |
|
2254 | Increase, cell proliferation (hepatocytes) | Increase, hepatocellular adenomas and carcinomas | Dec 31, 2020 | Dec 31, 2020 |
|
773 | Increase, cell proliferation (hepatocytes) | Increase, Preneoplastic foci (hepatocytes) | Nov 29, 2016 | Feb 14, 2017 |
|
714 | Binding, Tubulin | Disruption, Microtubule dynamics | Nov 29, 2016 | May 27, 2019 |
|
724 | Binding, Tubulin | Altered, Chromosome number | Nov 29, 2016 | Dec 13, 2019 |
|
715 | Disruption, Microtubule dynamics | Disorganization, Meiotic Spindle | Nov 29, 2016 | Dec 13, 2019 |
|
737 | Disorganization, Meiotic Spindle | Altered, Meiotic chromosome dynamics | Nov 29, 2016 | Dec 13, 2019 |
|
723 | Altered, Chromosome number | Increase, Aneuploid offspring | Nov 29, 2016 | Dec 13, 2019 |
|
716 | Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme | Increased, Induction of pyruvate dehydrogenase (PDH) | Nov 29, 2016 | Dec 3, 2016 |
|
762 | Increased, Induction of pyruvate dehydrogenase (PDH) | Increase, Oxidative metabolism | Nov 29, 2016 | Dec 3, 2016 |
|
726 | Increase, Necrosis (terminal bronchiolar cells) | Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) | Nov 29, 2016 | Dec 3, 2016 |
|
727 | Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) | Increase, Hyperplasia (terminal bronchiolar cells) | Nov 29, 2016 | Dec 3, 2016 |
|
728 | Increase, Hyperplasia (terminal bronchiolar cells) | Increase, Adenomas/carcinomas (bronchioloalveolar) | Nov 29, 2016 | Dec 3, 2016 |
|
768 | Decreased, Uptake of inorganic iodide | Decrease, Serum thyroid hormone (T4/T3) | Nov 29, 2016 | Dec 3, 2016 | |
2421 | Decreased, Uptake of inorganic iodide | TH synthesis, Decreased | Jul 7, 2021 | Jul 7, 2021 | |
742 | Increase, Hypertrophy and proliferation (follicular cell) | Increase, Hyperplasia (follicular cells) | Nov 29, 2016 | Dec 3, 2016 |
|
743 | Increase, Hyperplasia (follicular cells) | Increase, Adenomas/carcinomas (follicular cell) | Nov 29, 2016 | Dec 3, 2016 |
|
729 | Decreased, Androgen receptor activity | Decreased, Testosterone binding to androgen receptor (hypothalamus) | Nov 29, 2016 | Dec 3, 2016 |
|
730 | Decreased, Testosterone binding to androgen receptor (hypothalamus) | Increase, Hyperplasia (Leydig cells) | Nov 29, 2016 | Dec 3, 2016 | |
744 | Decreased, Testosterone binding to androgen receptor (hypothalamus) | Increased, Luteinizing hormone (LH) | Nov 29, 2016 | Dec 3, 2016 |
|
731 | Increase, Hyperplasia (Leydig cells) | Increase, Leydig cell tumors | Nov 29, 2016 | Dec 3, 2016 |
|
732 | Increase, Dopaminergic activity | Decreased, Prolactin | Nov 29, 2016 | Dec 3, 2016 |
|
770 | Increase, Dopaminergic activity | Increase, Endometrial adenocarcinomas | Nov 29, 2016 | Dec 3, 2016 | |
733 | Decreased, Prolactin | Increased, Estrogen receptor (ER) activity | Nov 29, 2016 | Dec 3, 2016 |
|
734 | Increased, Estrogen receptor (ER) activity | Decreased, Progesterone from corpus luteum | Nov 29, 2016 | Dec 3, 2016 |
|
2737 | Increased, Estrogen receptor (ER) activity | Increase, Vitellogenin mRNA | Aug 28, 2022 | Aug 28, 2022 |
|
772 | Decreased, Progesterone from corpus luteum | Increase, Hyperplasia (glandular epithelial cells of endometrium) | Nov 29, 2016 | Dec 3, 2016 |
|
738 | Altered, Meiotic chromosome dynamics | Altered, Chromosome number | Nov 29, 2016 | Dec 13, 2019 |
|
2554 | Altered, Meiotic chromosome dynamics | Increase, Pollen abnormal | Jan 21, 2022 | Jan 21, 2022 |
|
2384 | Altered, Meiotic chromosome dynamics | Decreased spermatogenesis | May 12, 2021 | May 12, 2021 |
|
2383 | Altered, Meiotic chromosome dynamics | Increase, Oocyte apoptosis | May 12, 2021 | May 12, 2021 |
|
2391 | Altered, Meiotic chromosome dynamics | Ionizing Energy | May 12, 2021 | May 12, 2021 | |
741 | Increase, Thyroid-stimulating hormone (TSH) | Increase, Hypertrophy and proliferation (follicular cell) | Nov 29, 2016 | Dec 3, 2016 | |
745 | Increased, Luteinizing hormone (LH) | Increase, Hyperplasia (Leydig cells) | Nov 29, 2016 | Dec 3, 2016 |
|
747 | Hippocampal gene expression, Altered | Hippocampal anatomy, Altered | Nov 29, 2016 | Aug 11, 2018 |
|
2886 | Hippocampal gene expression, Altered | Hippocampal Physiology, Altered | Apr 12, 2023 | Apr 12, 2023 |
|
749 | Hippocampal anatomy, Altered | Hippocampal Physiology, Altered | Nov 29, 2016 | Jul 25, 2024 |
|
748 | Hippocampal Physiology, Altered | Cognitive function, decreased | Nov 29, 2016 | Jul 26, 2024 |
|
2864 | Hippocampal Physiology, Altered | Impairment, Learning and memory | Apr 3, 2023 | Apr 3, 2023 |
|
2484 | Hippocampal Physiology, Altered | Loss, Cochlear function | Sep 14, 2021 | Sep 14, 2021 |
|
2466 | Increased, Kidney Failure | Increased Mortality | Aug 11, 2021 | Aug 11, 2021 |
|
2462 | Increased, Kidney Failure | Increase, Mortality | Aug 5, 2021 | Aug 5, 2021 | |
752 | Activation, Glutamate-gated chloride channel | Increased, Chloride conductance | Nov 29, 2016 | Dec 3, 2016 |
|
758 | Increased, Chloride conductance | hyperpolarisation, neuron | Nov 29, 2016 | Dec 3, 2016 |
|
1052 | Increased, Chloride conductance | Increased, Neuronal synaptic inhibition | Nov 29, 2016 | Dec 3, 2016 |
|
1051 | Activation, ionotropic GABA Receptor chloride channel | Increased, Chloride conductance | Nov 29, 2016 | Dec 3, 2016 |
|
1566 | hyperpolarisation, neuron | Analgesia | Jun 8, 2017 | Jun 8, 2017 |
|
1572 | hyperpolarisation, neuron | Anti-depressant Activity | Jun 23, 2017 | Jun 23, 2017 |
|
755 | hyperpolarisation, neuron | N/A, Ataxia, paralysis, or hyperactivity | Nov 29, 2016 | Dec 3, 2016 |
|
757 | N/A, Ataxia, paralysis, or hyperactivity | Increased Mortality | Nov 29, 2016 | Dec 3, 2016 |
|
775 | Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme | Increased, Plasma tyrosine | Nov 29, 2016 | Dec 3, 2016 |
|
761 | Increase, Hyperplasia (renal tubular cells) | Increase, Adenomas/carcinomas (renal tubular) | Nov 29, 2016 | Dec 3, 2016 |
|
766 | Increase, Cytotoxicity | Increase, hepatocellular adenomas and carcinomas | Nov 29, 2016 | Dec 3, 2016 |
|
887 | Increase, Cytotoxicity | Increase, Tissue Degeneration, Necrosis & Atrophy | Nov 29, 2016 | Nov 29, 2016 |
|
763 | Increase, Oxidative metabolism | Peptide Oxidation | Nov 29, 2016 | Dec 3, 2016 |
|
767 | Increase, Cytotoxicity (club cells) | Increase, Necrosis (terminal bronchiolar cells) | Nov 29, 2016 | Dec 3, 2016 |
|
769 | Decrease, Serum thyroid hormone (T4/T3) | Increase, Thyroid-stimulating hormone (TSH) | Nov 29, 2016 | Dec 3, 2016 | |
771 | Increase, Hyperplasia (glandular epithelial cells of endometrium) | Increase, Endometrial adenocarcinomas | Nov 29, 2016 | Dec 3, 2016 |
|
2972 | Increase, Hyperplasia (glandular epithelial cells of endometrium) | Genomic instability | Jul 27, 2023 | Jul 27, 2023 |
|
774 | Increase, Preneoplastic foci (hepatocytes) | Increase, hepatocellular adenomas and carcinomas | Nov 29, 2016 | Feb 15, 2017 |
|
776 | Increased, Plasma tyrosine | Increase, Cytotoxicity (corneal cells) | Nov 29, 2016 | Dec 3, 2016 |
|
777 | Increase, Cytotoxicity (corneal cells) | Increase, Inflammation (corneal cells) | Nov 29, 2016 | Dec 3, 2016 |
|
778 | Increase, Inflammation (corneal cells) | Increase, Regenerative cell proliferation (corneal cells) | Nov 29, 2016 | Dec 3, 2016 |
|
779 | Increase, Regenerative cell proliferation (corneal cells) | Increase, Papillomas/carcinomas (squamous cells) | Nov 29, 2016 | Dec 3, 2016 |
|
780 | Increase, Cytotoxicity (epithelial cells) | Increase, Inflammation | Nov 29, 2016 | Dec 3, 2016 |
|
2659 | Increase, Cytotoxicity (epithelial cells) | Increased, Reactive oxygen species | May 25, 2022 | May 25, 2022 |
|
2664 | Increase, Cytotoxicity (epithelial cells) | Secondary genotoxicity | May 25, 2022 | May 25, 2022 |
|
782 | Increase, Regenerative cell proliferation (forestomach epithelial cells) | Increase, Hyperplasia (forestomach epithelial cells) | Nov 29, 2016 | Dec 3, 2016 |
|
783 | Increase, Hyperplasia (forestomach epithelial cells) | Increase, Papillomas/carcinomas (squamous cells) | Nov 29, 2016 | Dec 3, 2016 |
|
784 | Increase, Cytotoxicity (tubular epithelial cells) | Increase, Regenerative cell proliferation (tubular epithelial cells) | Nov 29, 2016 | Dec 3, 2016 |
|
786 | Increase, Hyperplasia (tubular epithelial cells) | Increase, Adenomas/carcinomas (renal tubular) | Nov 29, 2016 | Dec 3, 2016 |
|
787 | Activation, Androgen receptor | Increase, cell proliferation (hepatocytes) | Nov 29, 2016 | Dec 3, 2016 |
|
2913 | Activation, Androgen receptor | Decreased, Apoptosis (Epithelial Cells) | May 11, 2023 | May 11, 2023 |
|
2915 | Activation, Androgen receptor | Inflammatory events | May 11, 2023 | May 11, 2023 |
|
2908 | Activation, Androgen receptor | Altered, Transcription of genes by the AR | May 11, 2023 | May 11, 2023 |
|
788 | Increase, Cytotoxicity (hepatocytes) | Increase, Regenerative cell proliferation (hepatocytes) | Nov 29, 2016 | Dec 3, 2016 |
|
789 | Increase, Regenerative cell proliferation (hepatocytes) | Increase, Preneoplastic foci (hepatocytes) | Nov 29, 2016 | Dec 3, 2016 |
|
791 | Decrease, Incorporation of active iodide into iodotyrosines | Decrease, Serum thyroid hormone (T4/T3) | Nov 29, 2016 | Dec 3, 2016 | |
3226 | Inhibition, 5α-reductase activity | Decrease, circulating testosterone levels | May 24, 2024 | May 24, 2024 |
|
794 | Increased, Leutinizing hormone (LH) | Increase, Hyperplasia (Leydig cells) | Nov 29, 2016 | Dec 3, 2016 |
|
795 | Increase, Urinary bladder calculi | Increase, Cytotoxicity (urothelial cells) | Nov 29, 2016 | Dec 3, 2016 |
|
796 | Increase, Cytotoxicity (urothelial cells) | Increase, Regenerative cell proliferation (urothelial cells) | Nov 29, 2016 | Dec 3, 2016 |
|
797 | Increase, Regenerative cell proliferation (urothelial cells) | Increase, Hyperplasia (urothelial) | Nov 29, 2016 | Dec 3, 2016 |
|
798 | Increase, Hyperplasia (urothelial) | Increase, Adenomas/carcinomas (urothelial) | Nov 29, 2016 | Dec 3, 2016 |
|
2085 | Increase, Hyperplasia (urothelial) | carcinogenicity | Apr 21, 2020 | Apr 21, 2020 |
|
799 | Inhibition, Prolyl hydroxylases | Increased, HIF-1 heterodimer | Nov 29, 2016 | Dec 3, 2016 |
|
3369 | Inhibition, Prolyl hydroxylases | N/A, hypoxia | Oct 25, 2024 | Oct 25, 2024 |
|
800 | Increased, HIF-1 heterodimer | Decreased, Aromatase (Cyp19a1) mRNA | Nov 29, 2016 | Dec 3, 2016 |
|
801 | Decreased, Aromatase (Cyp19a1) mRNA | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | Nov 29, 2016 | Dec 3, 2016 |
|
802 | modulation, Unknown | Increased, HIF-1 alpha transcription | Nov 29, 2016 | Dec 3, 2016 |
|
803 | Increased, HIF-1 alpha transcription | Increased, HIF-1 heterodimer | Nov 29, 2016 | Dec 3, 2016 |
|
804 | Inhibition, HMG-CoA reductase | Decreased, mevalonate | Nov 29, 2016 | Dec 3, 2016 |
|
805 | Decreased, mevalonate | Decreased, cholesterol | Nov 29, 2016 | Dec 3, 2016 |
|
2072 | Decreased, cholesterol | Decreased, 11KT | Mar 23, 2020 | May 6, 2020 |
|
3201 | Decreased, cholesterol | Decrease, circulating testosterone levels | Apr 25, 2024 | Apr 25, 2024 |
|
808 | malformed, Male reproductive tract | Decrease, Fertility | Nov 29, 2016 | Dec 3, 2016 |
|
813 | Increased, Serum creatinine | Occurrence, Cytoplasmic vacuolization (Renal tubule) | Nov 29, 2016 | Dec 3, 2016 |
|
814 | Increased, Serum creatinine | Occurrence, Cystic dilatation (renal tubule) | Nov 29, 2016 | Dec 3, 2016 |
|
816 | Increased, Serum creatinine | Occurrence, Cytoplasmic vacuolization (podocyte) | Nov 29, 2016 | Dec 3, 2016 |
|
2648 | Occurrence, Kidney toxicity | Increased, Kidney Failure | Apr 8, 2022 | Apr 8, 2022 |
|
817 | Occurrence, Cytoplasmic vacuolization (Renal tubule) | Decreased, Glomerular filtration | Nov 29, 2016 | Dec 3, 2016 |
|
818 | Occurrence, Cytoplasmic vacuolization (Renal tubule) | Decreased, Renal plasma flow | Nov 29, 2016 | Dec 3, 2016 |
|
819 | Occurrence, Cytoplasmic vacuolization (Renal tubule) | Decreased, Sodium reabsorption | Nov 29, 2016 | Dec 3, 2016 |
|
820 | Occurrence, Cytoplasmic vacuolization (Renal tubule) | Decreased, Renal ability to dilute urine | Nov 29, 2016 | Dec 3, 2016 |
|
829 | Decreased, Glomerular filtration | Occurrence, Kidney toxicity | Nov 29, 2016 | Dec 3, 2016 |
|
830 | Decreased, Renal plasma flow | Occurrence, Kidney toxicity | Nov 29, 2016 | Dec 3, 2016 |
|
831 | Decreased, Sodium reabsorption | Occurrence, Kidney toxicity | Nov 29, 2016 | Dec 3, 2016 |
|
821 | Occurrence, Cystic dilatation (renal tubule) | Decreased, Glomerular filtration | Nov 29, 2016 | Dec 3, 2016 |
|
822 | Occurrence, Cystic dilatation (renal tubule) | Decreased, Renal plasma flow | Nov 29, 2016 | Dec 3, 2016 |
|
823 | Occurrence, Cystic dilatation (renal tubule) | Decreased, Sodium reabsorption | Nov 29, 2016 | Dec 3, 2016 |
|
824 | Occurrence, Cystic dilatation (renal tubule) | Decreased, Renal ability to dilute urine | Nov 29, 2016 | Dec 3, 2016 |
|
825 | Occurrence, Cytoplasmic vacuolization (podocyte) | Decreased, Glomerular filtration | Nov 29, 2016 | Dec 3, 2016 |
|
826 | Occurrence, Cytoplasmic vacuolization (podocyte) | Decreased, Renal plasma flow | Nov 29, 2016 | Dec 3, 2016 |
|
827 | Occurrence, Cytoplasmic vacuolization (podocyte) | Decreased, Sodium reabsorption | Nov 29, 2016 | Dec 3, 2016 |
|
828 | Occurrence, Cytoplasmic vacuolization (podocyte) | Decreased, Renal ability to dilute urine | Nov 29, 2016 | Dec 3, 2016 |
|
832 | Decreased, Renal ability to dilute urine | Occurrence, Kidney toxicity | Nov 29, 2016 | Dec 3, 2016 |
|
834 | Activation, Keratinocytes | Activation, Dendritic Cells | Nov 29, 2016 | Dec 3, 2016 |
|
836 | Inhibition, Phospholipase A | Damage, Lipid bilayer | Nov 29, 2016 | Dec 3, 2016 |
|
837 | Inhibition, Phospholipase A | Disturbance, Lysosomal function | Nov 29, 2016 | Dec 3, 2016 |
|
3154 | Inhibition, Phospholipase A | Mitochondrial dysfunction | Mar 13, 2024 | Mar 13, 2024 |
|
839 | Damage, Lipid bilayer | Occurrence, Cytoplasmic vacuolization (hepatocyte) | Nov 29, 2016 | Dec 3, 2016 |
|
840 | Damage, Lipid bilayer | Occurrence, Ballooning degeneration (hepatocyte) | Nov 29, 2016 | Dec 3, 2016 |
|
841 | Damage, Lipid bilayer | Occurrence, Cytoplasmic vacuolization (Bile duct cell) | Nov 29, 2016 | Dec 3, 2016 |
|
842 | Damage, Lipid bilayer | Occurrence, Cytoplasmic vacuolization (kupffer cell) | Nov 29, 2016 | Dec 3, 2016 |
|
843 | Disturbance, Lysosomal function | Occurrence, Cytoplasmic vacuolization (hepatocyte) | Nov 29, 2016 | Dec 3, 2016 |
|
844 | Disturbance, Lysosomal function | Occurrence, Ballooning degeneration (hepatocyte) | Nov 29, 2016 | Dec 3, 2016 |
|
845 | Disturbance, Lysosomal function | Occurrence, Cytoplasmic vacuolization (Bile duct cell) | Nov 29, 2016 | Dec 3, 2016 |
|
846 | Disturbance, Lysosomal function | Occurrence, Cytoplasmic vacuolization (kupffer cell) | Nov 29, 2016 | Dec 3, 2016 |
|
1678 | Disturbance, Lysosomal function | Disruption, Lysosome | Oct 25, 2017 | Oct 25, 2017 |
|
851 | Occurrence, Cytoplasmic vacuolization (hepatocyte) | Induction, Microvesicular fat | Nov 29, 2016 | Dec 3, 2016 |
|
852 | Occurrence, Cytoplasmic vacuolization (hepatocyte) | Formation, Mallory body | Nov 29, 2016 | Dec 3, 2016 |
|
853 | Occurrence, Ballooning degeneration (hepatocyte) | Induction, Microvesicular fat | Nov 29, 2016 | Dec 3, 2016 |
|
854 | Occurrence, Ballooning degeneration (hepatocyte) | Formation, Mallory body | Nov 29, 2016 | Dec 3, 2016 |
|
855 | Occurrence, Cytoplasmic vacuolization (Bile duct cell) | Induction, Microvesicular fat | Nov 29, 2016 | Dec 3, 2016 |
|
856 | Occurrence, Cytoplasmic vacuolization (Bile duct cell) | Formation, Mallory body | Nov 29, 2016 | Dec 3, 2016 |
|
857 | Occurrence, Cytoplasmic vacuolization (kupffer cell) | Induction, Microvesicular fat | Nov 29, 2016 | Dec 3, 2016 |
|
858 | Occurrence, Cytoplasmic vacuolization (kupffer cell) | Formation, Mallory body | Nov 29, 2016 | Dec 3, 2016 |
|
859 | Induction, Microvesicular fat | Formation, Liver fibrosis | Nov 29, 2016 | Dec 3, 2016 |
|
860 | Formation, Mallory body | Formation, Liver fibrosis | Nov 29, 2016 | Dec 3, 2016 |
|
864 | Oxidation, Uroporphyrinogen | Accumulation, Highly carboxylated porphyrins | Nov 29, 2016 | Nov 29, 2016 | |
865 | Oxidation, Uroporphyrinogen | Inhibition, UROD | Nov 29, 2016 | May 30, 2018 |
|
867 | Inhibition, UROD | Oxidation, Uroporphyrinogen | Nov 29, 2016 | Nov 29, 2016 | |
1070 | Inhibition, UROD | Accumulation, Highly carboxylated porphyrins | Nov 29, 2016 | May 30, 2018 |
|
866 | Accumulation, Highly carboxylated porphyrins | Uroporphyria | Nov 29, 2016 | May 7, 2018 |
|
868 | Induction, CYP1A2/CYP1A5 | Oxidation, Uroporphyrinogen | Nov 29, 2016 | May 31, 2018 |
|
2907 | Induction, CYP1A2/CYP1A5 | Increase, Oxidative Stress | May 4, 2023 | May 4, 2023 | |
2893 | Induction, CYP1A2/CYP1A5 | Increase, ROS | Apr 13, 2023 | Apr 13, 2023 | |
3275 | Induction, CYP1A2/CYP1A5 | Oxidative Stress | Jul 4, 2024 | Jul 4, 2024 |
|
871 | GABAergic interneurons, Decreased | Synaptogenesis, Decreased | Nov 29, 2016 | Jan 19, 2018 |
|
995 | Changes/Inhibition, Cellular Homeostasis and Apoptosis | N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects | Nov 29, 2016 | Dec 2, 2016 |
|
997 | Alterations, Cellular proliferation / hyperplasia | Formation, Hepatocellular and Bile duct tumors | Nov 29, 2016 | Dec 2, 2016 |
|
2911 | Alterations, Cellular proliferation / hyperplasia | prostatic intraepithelial neoplasia | May 11, 2023 | May 11, 2023 |
|
877 | Binding as antagonist, Antagonist binding to PPARalpha ligand binding domain | Decreased, PPARalpha transactivation of gene expression | Nov 29, 2016 | Nov 29, 2016 | |
880 | Decreased, PPARalpha transactivation of gene expression | Decreased, Ketogenesis (production of ketone bodies) | Nov 29, 2016 | Jun 11, 2018 |
|
879 | Decreased, PPARalpha transactivation of gene expression | Decreased, Mitochondrial Fatty Acid Beta Oxidation | Nov 29, 2016 | Jun 2, 2017 | |
878 | Decreased, PPARalpha transactivation of gene expression | Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids | Nov 29, 2016 | Jun 2, 2017 | |
1748 | Decreased, PPARalpha transactivation of gene expression | Fatty Acid Beta Oxidation, Decreased | Jun 11, 2018 | Jun 11, 2018 |
|
881 | Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids | Decreased, Mitochondrial Fatty Acid Beta Oxidation | Nov 29, 2016 | Nov 29, 2016 | |
882 | Decreased, Mitochondrial Fatty Acid Beta Oxidation | Decreased, Ketogenesis (production of ketone bodies) | Nov 29, 2016 | Nov 29, 2016 | |
2264 | Decreased, Mitochondrial Fatty Acid Beta Oxidation | Accumulation, Triglyceride | Jan 15, 2021 | Jan 15, 2021 |
|
2040 | Decreased, Mitochondrial Fatty Acid Beta Oxidation | Increased, Liver Steatosis | Feb 22, 2020 | Feb 22, 2020 | |
883 | Decreased, Ketogenesis (production of ketone bodies) | Not Increased, Circulating Ketone Bodies | Nov 29, 2016 | Jun 11, 2018 |
|
884 | Not Increased, Circulating Ketone Bodies | Increased, Catabolism of Muscle Protein | Nov 29, 2016 | Jun 11, 2018 |
|
885 | Increased, Catabolism of Muscle Protein | Decreased, Body Weight | Nov 29, 2016 | Jun 11, 2018 |
|
886 | Decrease, Intracellular pH | Increase, Cytotoxicity | Nov 29, 2016 | Nov 29, 2016 |
|
888 | Increase, Tissue Degeneration, Necrosis & Atrophy | Increase, Respiratory or Squamous Metaplasia | Nov 29, 2016 | Dec 1, 2016 |
|
889 | Increase, Respiratory or Squamous Metaplasia | Increase, Cell Proliferation | Nov 29, 2016 | Dec 1, 2016 |
|
890 | Increase, Cell Proliferation | Increased, Induced Mutations in Critical Genes | Nov 29, 2016 | Dec 3, 2016 | |
893 | Increase, Cell Proliferation | Increase, Mutations in Critical Genes | Nov 29, 2016 | Dec 3, 2016 |
|
895 | Increase, Cell Proliferation | Increase, Site of Contact Nasal Tumors | Nov 29, 2016 | Dec 1, 2016 |
|
2819 | Increase, Cell Proliferation | Cataracts | Dec 18, 2022 | Mar 8, 2024 |
|
2419 | Increase, Cell Proliferation | Increased, mesotheliomas | Jul 6, 2021 | Jul 6, 2021 |
|
1967 | Increase, Cell Proliferation | Lung cancer | Jul 3, 2019 | Jul 3, 2019 |
|
1980 | Increase, Cell Proliferation | Increase, lung cancer | Aug 29, 2019 | Jan 10, 2023 |
|
919 | Binding of agonist, Ionotropic glutamate receptors | Overactivation, NMDARs | Nov 29, 2016 | Nov 29, 2016 |
|
894 | Increase, Mutations in Critical Genes | Increase, Site of Contact Nasal Tumors | Nov 29, 2016 | Dec 1, 2016 |
|
1131 | Inhibition, organic anion transporter 1 (OAT1) | Increased, blood uric acid concentration | Nov 29, 2016 | Dec 3, 2016 |
|
934 | Inhibition, NADH-ubiquinone oxidoreductase (complex I) | Mitochondrial dysfunction | Nov 29, 2016 | Aug 25, 2017 |
|
1940 | Inhibition, NADH-ubiquinone oxidoreductase (complex I) | Decrease in mitochondrial oxidative phosphorylation | Jun 7, 2019 | Jun 7, 2019 |
|
1809 | Inhibition, NADH-ubiquinone oxidoreductase (complex I) | Decrease, OXPHOS | Dec 20, 2018 | Dec 20, 2018 |
|
933 | Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) | Inhibition, NADH-ubiquinone oxidoreductase (complex I) | Nov 29, 2016 | Aug 25, 2017 |
|
905 | Impaired, Proteostasis | Degeneration of dopaminergic neurons of the nigrostriatal pathway | Nov 29, 2016 | Aug 25, 2017 |
|
1943 | Impaired, Proteostasis | Cell injury/death | Jun 7, 2019 | Jun 7, 2019 |
|
907 | Degeneration of dopaminergic neurons of the nigrostriatal pathway | Neuroinflammation | Nov 29, 2016 | Oct 2, 2017 |
|
910 | Degeneration of dopaminergic neurons of the nigrostriatal pathway | Parkinsonian motor deficits | Nov 29, 2016 | Aug 25, 2017 |
|
3077 | Degeneration of dopaminergic neurons of the nigrostriatal pathway | impaired, Learning and memory | Oct 17, 2023 | Oct 17, 2023 |
|
3083 | Parkinsonian motor deficits | Increase, Mortality | Oct 17, 2023 | Oct 17, 2023 |
|
921 | Disruption, Lysosome | Peptide Oxidation | Nov 29, 2016 | Nov 29, 2016 | |
911 | Disruption, Lysosome | Increase, ROS | Nov 29, 2016 | Dec 3, 2016 | |
993 | Disruption, Lysosome | Mitochondrial dysfunction | Nov 29, 2016 | Nov 12, 2018 |
|
1679 | Disruption, Lysosome | Increase, Cytotoxicity (renal tubular cell) | Oct 25, 2017 | Oct 25, 2017 |
|
916 | Infiltration, Inflammatory cells | Inflammation, Liver | Nov 29, 2016 | Nov 29, 2016 | |
3374 | Infiltration, Inflammatory cells | Activation, Macrophages | Oct 30, 2024 | Oct 30, 2024 |
|
926 | Infiltration, Inflammatory cytokines | Inflammation, Liver | Nov 29, 2016 | Dec 3, 2016 | |
936 | Activation, Epidermal Growth Factor Receptor | Decreased ciliated cell apoptosis | Nov 29, 2016 | Dec 3, 2016 | |
946 | Activation, Epidermal Growth Factor Receptor | Activation, Sp1 | Nov 29, 2016 | Dec 3, 2016 | |
939 | Activation, Epidermal Growth Factor Receptor | Increased goblet cell proliferation | Nov 29, 2016 | Dec 3, 2016 | |
942 | Activation, Epidermal Growth Factor Receptor | Occurrence, Transdifferentiation of ciliated epithelial cells | Nov 29, 2016 | Nov 29, 2016 | |
961 | Decreased ciliated cell apoptosis | Occurrence, Transdifferentiation of ciliated epithelial cells | Nov 29, 2016 | Aug 25, 2021 | |
2470 | Decreased ciliated cell apoptosis | Goblet cell metaplasia | Aug 25, 2021 | Aug 25, 2021 | |
943 | Occurrence, Transdifferentiation of ciliated epithelial cells | Goblet cell metaplasia | Nov 29, 2016 | Aug 11, 2021 | |
990 | Goblet cell metaplasia | Hypersecretion, Mucus | Nov 29, 2016 | Nov 29, 2016 | |
2471 | Goblet cell metaplasia | Chronic, Mucus hypersecretion | Aug 26, 2021 | Aug 27, 2021 | |
1313 | Goblet cell metaplasia | Increase, Mucin production | Nov 29, 2016 | Aug 11, 2021 | |
1312 | Goblet cell hyperplasia | Increase, Mucin production | Nov 29, 2016 | Aug 11, 2021 | |
2472 | Goblet cell hyperplasia | Chronic, Mucus hypersecretion | Aug 26, 2021 | Aug 30, 2021 | |
989 | Goblet cell hyperplasia | Hypersecretion, Mucus | Nov 29, 2016 | Nov 29, 2016 | |
944 | Increased goblet cell proliferation | Goblet cell hyperplasia | Nov 29, 2016 | Aug 27, 2021 | |
987 | Activation, Sp1 | Increase, Mucin production | Nov 29, 2016 | Aug 11, 2021 | |
954 | Oxidation, Glutathione | S-Glutathionylation, eNOS | Nov 29, 2016 | Sep 28, 2017 | |
2459 | Oxidation, Glutathione | Increased, Reactive oxygen species | Aug 5, 2021 | Aug 5, 2021 |
|
955 | S-Glutathionylation, eNOS | Uncoupling, eNOS | Nov 29, 2016 | Oct 12, 2017 |
|
956 | Uncoupling, eNOS | Depletion, Nitric Oxide | Nov 29, 2016 | Oct 12, 2017 |
|
3014 | Uncoupling, eNOS | Increase, Vascular disrupting effects | Aug 21, 2023 | Aug 21, 2023 | |
3023 | Uncoupling, eNOS | increased,Vascular endothelial dysfunction | Aug 21, 2023 | Aug 21, 2023 |
|
958 | Depletion, Nitric Oxide | Impaired, Vasodilation | Nov 29, 2016 | Oct 12, 2017 |
|
953 | Decrease, Tetrahydrobiopterin | Uncoupling, eNOS | Nov 29, 2016 | Oct 12, 2017 |
|
952 | Decrease, GTPCH-1 | Decrease, Tetrahydrobiopterin | Nov 29, 2016 | Oct 12, 2017 |
|
982 | Impaired, Vasodilation | Increase, Vascular Resistance | Nov 29, 2016 | Oct 13, 2017 |
|
986 | Activation, EGFR | Increase, Mucin production | Nov 29, 2016 | Mar 9, 2023 |
|
962 | Activation, EGFR | Decreased ciliated cell apoptosis | Nov 29, 2016 | Aug 27, 2021 | |
964 | Activation, EGFR | Activation, Sp1 | Nov 29, 2016 | Aug 11, 2021 | |
965 | Activation, EGFR | Occurrence, Transdifferentiation of ciliated epithelial cells | Nov 29, 2016 | Aug 25, 2021 | |
970 | Activation, EGFR | Increased goblet cell proliferation | Nov 29, 2016 | Aug 27, 2021 | |
2469 | Activation, EGFR | Goblet cell metaplasia | Aug 25, 2021 | Aug 27, 2021 | |
2857 | Activation, EGFR | Increase, goblet cell number | Mar 15, 2023 | Mar 16, 2023 |
|
973 | dimerization, AHR/ARNT | reduced dimerization, ARNT/HIF1-alpha | Nov 29, 2016 | Mar 23, 2018 |
|
1350 | dimerization, AHR/ARNT | Increase, COX-2 expression | Feb 9, 2017 | May 9, 2017 |
|
1996 | dimerization, AHR/ARNT | Increase, DNMT expression | Oct 30, 2019 | Oct 30, 2019 |
|
2683 | dimerization, AHR/ARNT | Increase, slincR expression | Jun 30, 2022 | Sep 8, 2022 |
|
2682 | dimerization, AHR/ARNT | Decrease, sox9 expression | Jun 30, 2022 | Jun 30, 2022 | |
974 | reduced dimerization, ARNT/HIF1-alpha | reduced production, VEGF | Nov 29, 2016 | Mar 23, 2018 |
|
975 | reduced production, VEGF | Impairment, Endothelial network | Nov 29, 2016 | Mar 23, 2018 |
|
2407 | reduced production, VEGF | abnormal, placental labyrinth vasculature morphology | May 31, 2021 | May 31, 2021 |
|
983 | Increase, Vascular Resistance | Hypertension | Nov 29, 2016 | Oct 13, 2017 |
|
2245 | Binding, Transthyretin in serum | Displacement, Serum thyroxine (T4) from transthyretin | Dec 9, 2020 | Dec 9, 2020 |
|
2248 | Binding, Transthyretin in serum | Displacement, Serum thyroxine (T4) from carrier protein | Dec 9, 2020 | Dec 9, 2020 |
|
2269 | Binding, Transthyretin in serum | Increased, Clearance of thyroxine from serum | Jan 26, 2021 | Jan 26, 2021 | |
2271 | Binding, Transthyretin in serum | Increased, Free serum thyroxine (T4) | Jan 26, 2021 | Jan 26, 2021 | |
2246 | Displacement, Serum thyroxine (T4) from transthyretin | Increased, Free serum thyroxine (T4) | Dec 9, 2020 | Dec 9, 2020 |
|
2247 | Increased, Free serum thyroxine (T4) | Increased, Hepatic thyroid hormone uptake/transport | Dec 9, 2020 | Dec 9, 2020 |
|
2268 | Increased, Free serum thyroxine (T4) | Increased, Uptake of thyroxine into tissue | Jan 26, 2021 | Jan 26, 2021 | |
2272 | Increased, Free serum thyroxine (T4) | Increased, Clearance of thyroxine from serum | Jan 26, 2021 | Jan 26, 2021 |
|
2270 | Increased, Clearance of thyroxine from serum | T4 in serum, Decreased | Jan 26, 2021 | Jan 26, 2021 |
|
1315 | Increase, Mucin production | Chronic, Mucus hypersecretion | Nov 29, 2016 | Aug 30, 2021 | |
2859 | Increase, Mucin production | Decreased lung function | Mar 15, 2023 | Mar 16, 2023 |
|
991 | Increase, Mucin production | Hypersecretion, Mucus | Nov 29, 2016 | Nov 29, 2016 | |
988 | Decrease, AKT/eNOS activity | Depletion, Nitric Oxide | Nov 29, 2016 | Oct 16, 2017 |
|
1062 | Formation, The binding of FK506 with FKBP12 | Inhibition, Calcineurin Activity | Nov 29, 2016 | Dec 3, 2016 | |
1016 | Activation, Suppression of NFAT activation and hindrance of nuclear localization | Interference, nuclear localization of NFAT | Nov 29, 2016 | Dec 3, 2016 | |
1017 | Interference, nuclear localization of NFAT | Reduction, NFAT/AP-1 complex formation | Nov 29, 2016 | Jul 2, 2021 |
|
1015 | Inhibition, Calcineurin Activity | Activation, Suppression of NFAT activation and hindrance of nuclear localization | Nov 29, 2016 | Dec 3, 2016 | |
1508 | Inhibition, Calcineurin Activity | Interference, nuclear localization of NFAT | May 19, 2017 | Jun 27, 2021 |
|
1254 | Inhibition, Calcineurin Activity | Suppression, IL-2 and IL-4 production | Nov 29, 2016 | Dec 3, 2016 | |
1256 | Reduction, NFAT/AP-1 complex formation | Suppression, Suppression of production of cytotoxic T-cells | Nov 29, 2016 | Dec 3, 2016 | |
1257 | Reduction, NFAT/AP-1 complex formation | Suppression, Suppression of T-cell dependent antibody production | Nov 29, 2016 | Dec 3, 2016 | |
1509 | Reduction, NFAT/AP-1 complex formation | Suppression, IL-2 and IL-4 production | May 19, 2017 | Jun 27, 2021 |
|
1018 | Reduction, NFAT/AP-1 complex formation | Suppression, Suppression in mixed lymphocyte reaction (MLR) | Nov 29, 2016 | Dec 3, 2016 | |
1019 | Reduction, NFAT/AP-1 complex formation | Suppression, Suppression of T-cell dependent antibody response (TDAR) | Nov 29, 2016 | Dec 3, 2016 | |
1020 | Reduction, NFAT/AP-1 complex formation | Impairment, T-cell dependent antibody response | Nov 29, 2016 | Dec 3, 2016 | |
1021 | Reduction, NFAT/AP-1 complex formation | Relief, Relief of atopic dermatitis | Nov 29, 2016 | Dec 3, 2016 | |
1022 | Reduction, NFAT/AP-1 complex formation | Impairment of TDAR | Nov 29, 2016 | Dec 3, 2016 | |
1823 | Suppression, Suppression of T-cell dependent antibody response (TDAR) | Impairment of TDAR | Dec 25, 2018 | Dec 25, 2018 | |
1000 | Decrease, Circulating ETH | Increase, Incomplete ecdysis | Nov 29, 2016 | Dec 3, 2016 | |
1008 | Decrease, Circulating ETH | Decrease, Abdominal muscle contraction | Nov 29, 2016 | Dec 3, 2016 | |
1346 | Decrease, Circulating ETH | Decrease, Circulating CCAP | Feb 9, 2017 | Feb 9, 2017 |
|
1001 | Decreased, synthesis and secretion of molting fluid proteases | Increase, Incomplete ecdysis | Nov 29, 2016 | Dec 3, 2016 | |
1002 | Increase, Incomplete ecdysis | Increase, Mortality | Nov 29, 2016 | Dec 3, 2016 |
|
1190 | Increase, Incomplete ecdysis | Increased Mortality | Nov 29, 2016 | Dec 3, 2016 | |
2759 | Increase, Incomplete ecdysis | Increase, developmental abnormalities | Aug 28, 2022 | Aug 28, 2022 |
|
2751 | Increase, Incomplete ecdysis | Decrease, hatching of egg | Aug 28, 2022 | Aug 28, 2022 |
|
2750 | Increase, Incomplete ecdysis | Increase, delay in oviposition | Aug 28, 2022 | Aug 28, 2022 |
|
1010 | Decrease, Abdominal muscle contraction | Increase, Incomplete ecdysis | Nov 29, 2016 | Dec 3, 2016 |
|
1009 | Decreased, Synthesis of molting fluid proteases | Decrease, Digestion of old cuticle | Nov 29, 2016 | Dec 3, 2016 | |
1011 | Decrease, Digestion of old cuticle | Increase, Incomplete ecdysis | Nov 29, 2016 | Dec 3, 2016 | |
2171 | Decrease, Digestion of old cuticle | Increase, Premature molting | Oct 21, 2020 | Oct 21, 2020 |
|
1023 | Binding of antagonist, PPAR alpha | stabilization, PPAR alpha co-repressor | Nov 29, 2016 | Jun 11, 2018 |
|
1024 | stabilization, PPAR alpha co-repressor | Decreased, PPARalpha transactivation of gene expression | Nov 29, 2016 | Jun 11, 2018 |
|
1199 | Inhibition, Deiodinase 2 | Decreased, Triiodothyronine (T3) in tissues | Nov 29, 2016 | Dec 3, 2016 |
|
1026 | Inhibition, Deiodinase 2 | Decreased, Triiodothyronine (T3) | Nov 29, 2016 | Oct 7, 2022 |
|
1042 | Inhibition, Deiodinase 2 | Reduced, Posterior swim bladder inflation | Nov 29, 2016 | Oct 7, 2022 |
|
1043 | Inhibition, Deiodinase 2 | Reduced, Anterior swim bladder inflation | Nov 29, 2016 | Mar 8, 2019 | |
1027 | Decreased, Triiodothyronine (T3) | Reduced, Posterior swim bladder inflation | Nov 29, 2016 | Oct 7, 2022 |
|
1035 | Decreased, Triiodothyronine (T3) | Reduced, Anterior swim bladder inflation | Nov 29, 2016 | Oct 7, 2022 |
|
2378 | Decreased, Triiodothyronine (T3) | Altered, Photoreceptor patterning | May 11, 2021 | Oct 17, 2021 |
|
2376 | Decreased, Triiodothyronine (T3) | Decreased, Eye size | May 11, 2021 | Jun 16, 2021 |
|
2373 | Decreased, Triiodothyronine (T3) | Altered, retinal layer structure | May 11, 2021 | Jul 8, 2022 |
|
2213 | Reduced, Posterior swim bladder inflation | Increased Mortality | Nov 30, 2020 | Sep 8, 2021 |
|
1031 | Reduced, Posterior swim bladder inflation | Reduced, Anterior swim bladder inflation | Nov 29, 2016 | Nov 20, 2020 | |
1028 | Reduced, Posterior swim bladder inflation | Reduced, Swimming performance | Nov 29, 2016 | Sep 3, 2021 |
|
1641 | Reduced, Swimming performance | Growth, reduction | Aug 3, 2017 | Aug 3, 2017 |
|
1642 | Reduced, Swimming performance | Decreased, survival | Aug 3, 2017 | Aug 3, 2017 |
|
2212 | Reduced, Swimming performance | Increased Mortality | Nov 30, 2020 | Sep 8, 2021 |
|
2081 | Reduced, Swimming performance | Decrease, Population growth rate | Apr 21, 2020 | Jun 4, 2020 |
|
1032 | Reduced, Anterior swim bladder inflation | Reduced, Hearing | Nov 29, 2016 | Dec 3, 2016 | |
1034 | Reduced, Anterior swim bladder inflation | Reduced, Swimming performance | Nov 29, 2016 | Oct 7, 2022 |
|
2231 | Reduced, Hearing | Increased Mortality | Dec 8, 2020 | Dec 8, 2020 |
|
1045 | Inhibition, Deiodinase 1 | Reduced, Anterior swim bladder inflation | Nov 29, 2016 | Mar 8, 2019 | |
1044 | Inhibition, Deiodinase 1 | Reduced, Posterior swim bladder inflation | Nov 29, 2016 | Oct 10, 2022 |
|
1037 | Inhibition, Deiodinase 1 | Decreased, Triiodothyronine (T3) | Nov 29, 2016 | Oct 10, 2022 |
|
1198 | Inhibition, Deiodinase 1 | Decreased, Triiodothyronine (T3) in tissues | Nov 29, 2016 | Dec 3, 2016 |
|
1047 | Increased, Chloride influx | Increased, Inhibitory postsynaptic potential | Nov 29, 2016 | Dec 3, 2016 | |
1054 | Increased, Inhibitory postsynaptic potential | Induction, Somatic muscle paralysis | Nov 29, 2016 | Dec 3, 2016 |
|
1048 | Increased, Inhibitory postsynaptic potential | Inhibition, Motor neuron activity | Nov 29, 2016 | Dec 3, 2016 | |
1058 | Increased, Inhibitory postsynaptic potential | Induction, pharyngeal muscle paralysis | Nov 29, 2016 | Dec 3, 2016 |
|
1049 | Inhibition, Motor neuron activity | Induction, Somatic muscle paralysis | Nov 29, 2016 | Dec 3, 2016 | |
1055 | Induction, Somatic muscle paralysis | Inhibition, Feeding | Nov 29, 2016 | Dec 3, 2016 |
|
1050 | Induction, Somatic muscle paralysis | Increased Mortality | Nov 29, 2016 | Dec 3, 2016 |
|
3089 | Induction, Somatic muscle paralysis | Increased, Neuronal synaptic inhibition | Oct 17, 2023 | Oct 17, 2023 |
|
3090 | Increased, Neuronal synaptic inhibition | Inhibition, Feeding | Oct 17, 2023 | Oct 17, 2023 |
|
1053 | Increased, Neuronal synaptic inhibition | Increased, Inhibitory postsynaptic potential | Nov 29, 2016 | Dec 3, 2016 |
|
1056 | Inhibition, Feeding | Increased Mortality | Nov 29, 2016 | Dec 3, 2016 |
|
3087 | Inhibition, Feeding | Increase, Mortality | Oct 17, 2023 | Oct 17, 2023 |
|
3084 | Activation, Glutamate-gated chloride channels | Overactivation, NMDARs | Oct 17, 2023 | Oct 17, 2023 |
|
3085 | Activation, Glutamate-gated chloride channels | Increase, CNS Neural cell death | Oct 17, 2023 | Oct 17, 2023 |
|
1057 | Activation, Glutamate-gated chloride channels | Increased, Chloride conductance | Nov 29, 2016 | Dec 3, 2016 |
|
1059 | Induction, pharyngeal muscle paralysis | Inhibition, Feeding | Nov 29, 2016 | Dec 3, 2016 |
|
1063 | Increased, induction of UDPGT's in liver | Increased, T4/T3 catabolism | Nov 29, 2016 | Dec 3, 2016 | |
1064 | Increased, T4/T3 catabolism | Decreased, serum T4/T3 | Nov 29, 2016 | Dec 3, 2016 | |
2423 | Increased, T4/T3 catabolism | T4 in serum, Decreased | Jul 7, 2021 | Jul 7, 2021 | |
1065 | Decreased, serum T4/T3 | Increased, Thyroid-stimulating hormone (TSH) | Nov 29, 2016 | Dec 3, 2016 | |
1066 | Increased, Thyroid-stimulating hormone (TSH) | Increased, Hypertrophy and proliferation (follicular cell) | Nov 29, 2016 | Dec 3, 2016 | |
2425 | Increased, Thyroid-stimulating hormone (TSH) | Increase, Thyroid-stimulating hormone (TSH) | Jul 7, 2021 | Jul 7, 2021 | |
2424 | Increased, Thyroid-stimulating hormone (TSH) | Increase, Hypertrophy and proliferation (follicular cell) | Jul 7, 2021 | Jul 7, 2021 |
|
2240 | Increased, Thyroid-stimulating hormone (TSH) | Increased, Thyroxine (T4) in serum | Dec 9, 2020 | Dec 9, 2020 |
|
2427 | Increased, Hypertrophy and proliferation (follicular cell) | Increase, Hyperplasia (follicular cells) | Jul 7, 2021 | Jul 7, 2021 | |
1067 | Increased, Hypertrophy and proliferation (follicular cell) | Increased, Hyperplasia (follicular cells) | Nov 29, 2016 | Dec 3, 2016 | |
1068 | Increased, Hyperplasia (follicular cells) | Increased Apoptosis, Adenomas/carcinomas (follicular cell) | Nov 29, 2016 | Dec 3, 2016 | |
2426 | Increased, Hyperplasia (follicular cells) | Increase, Adenomas/carcinomas (follicular cell) | Jul 7, 2021 | Jul 7, 2021 | |
1071 | Activation of specific nuclear receptors, PPAR-gamma activation | Increased, adipogenesis | Nov 29, 2016 | Dec 3, 2016 |
|
1072 | Activation of specific nuclear receptors, PPAR-gamma activation | Increased, secretion of local growth factors | Nov 29, 2016 | Dec 3, 2016 |
|
1609 | Activation of specific nuclear receptors, PPAR-gamma activation | increased adipogenesis | Jul 24, 2017 | Jul 24, 2017 |
|
1073 | Increased, adipogenesis | Increased, secretion of local growth factors | Nov 29, 2016 | Dec 3, 2016 |
|
1074 | Increased, secretion of local growth factors | Increased, proliferation of mesenchymal cells | Nov 29, 2016 | Dec 3, 2016 |
|
1075 | Increased, secretion of local growth factors | Increased, IGF-1 (mouse) | Nov 29, 2016 | Dec 3, 2016 |
|
1624 | Increased, secretion of local growth factors | Differentiation of fibroblasts | Jul 26, 2017 | Jul 26, 2017 | |
1625 | Increased, secretion of local growth factors | EMT | Jul 26, 2017 | Jul 26, 2017 | |
1129 | Increased, secretion of local growth factors | Increased, Cell Proliferation (mesothelium) | Nov 29, 2016 | Dec 3, 2016 |
|
1076 | Increased, proliferation of mesenchymal cells | Increased, Firbrosarcoma | Nov 29, 2016 | Dec 3, 2016 |
|
1077 | Increased, proliferation of mesenchymal cells | Increased, liposarcoma | Nov 29, 2016 | Dec 3, 2016 |
|
1078 | Increased, proliferation of mesenchymal cells | Increased, hemagiosarcoma | Nov 29, 2016 | Dec 3, 2016 |
|
1079 | Activation, beta-2 adrenergic receptor | Increased activity, beta-2 adrenergic receptor | Nov 29, 2016 | Dec 3, 2016 |
|
3416 | Activation, beta-2 adrenergic receptor | Intracellular cAMP | Nov 21, 2024 | Nov 21, 2024 |
|
1080 | Increased activity, beta-2 adrenergic receptor | relaxation, smooth muscle | Nov 29, 2016 | Dec 3, 2016 |
|
1081 | relaxation, smooth muscle | Proliferation/Clonal Expansion, smooth muscle | Nov 29, 2016 | Dec 3, 2016 |
|
1082 | Proliferation/Clonal Expansion, smooth muscle | Hypertrophy/hyperplasia, smooth muscle | Nov 29, 2016 | Dec 3, 2016 |
|
1083 | Hypertrophy/hyperplasia, smooth muscle | Promotion, mesovarian leiomyomas | Nov 29, 2016 | Dec 3, 2016 |
|
1084 | Decreased, Ovarian E2 | Increased, secretion of GnRH from hypothalamus | Nov 29, 2016 | Dec 3, 2016 | |
1085 | Decreased, Ovarian E2 | Decrease, E2 blood concentrations at hypothalamus | Nov 29, 2016 | Dec 3, 2016 |
|
1086 | Suppression, Estrogen receptor (ER) activity | Decrease, E2 blood concentrations at hypothalamus | Nov 29, 2016 | Dec 3, 2016 |
|
2580 | Suppression, Estrogen receptor (ER) activity | Increased, secretion of GnRH from hypothalamus | Feb 26, 2022 | Mar 1, 2022 |
|
1088 | Increased, secretion of GnRH from hypothalamus | Increased, secrection of FSH from anterior pituitary | Nov 29, 2016 | Dec 3, 2016 |
|
1089 | Increased, secretion of GnRH from hypothalamus | Increased, secretion of LH from anterior pituitary | Nov 29, 2016 | Mar 1, 2022 |
|
1090 | Increased, secrection of FSH from anterior pituitary | Hyperplasia, ovarian stromal cells | Nov 29, 2016 | Dec 3, 2016 |
|
1091 | Increased, secrection of FSH from anterior pituitary | Hyperplasia, ovarian epithelium | Nov 29, 2016 | Dec 3, 2016 |
|
1092 | Increased, secretion of LH from anterior pituitary | Hyperplasia, ovarian stromal cells | Nov 29, 2016 | Dec 3, 2016 |
|
2581 | Increased, secretion of LH from anterior pituitary | Increased, Steroidogenic acute regulatory protein (StAR) | Feb 26, 2022 | Mar 1, 2022 |
|
1094 | Hyperplasia, ovarian stromal cells | Promotion, ovarian granular cell tumors | Nov 29, 2016 | Dec 3, 2016 |
|
1093 | Hyperplasia, ovarian epithelium | Promotion, ovarian adenomas | Nov 29, 2016 | Dec 3, 2016 |
|
2829 | Promotion, ovarian adenomas | Promotion, Ovarian Cancer | Jan 13, 2023 | Mar 11, 2023 |
|
2830 | Promotion, ovarian granular cell tumors | Promotion, Ovarian Cancer | Jan 13, 2023 | Jan 13, 2023 | |
1087 | Decrease, E2 blood concentrations at hypothalamus | Increased, secretion of GnRH from hypothalamus | Nov 29, 2016 | Dec 3, 2016 |
|
1095 | Increased, PPAR-alpha activation | Decreased, bile flow | Nov 29, 2016 | Dec 3, 2016 |
|
1096 | Increased, PPAR-alpha activation | Increased, cholestasis | Nov 29, 2016 | Dec 3, 2016 |
|
1097 | Increased, PPAR-alpha activation | Alteration, lipid metabolism | Nov 29, 2016 | Dec 3, 2016 |
|
1101 | Decreased, bile flow | Increased, cholestasis | Nov 29, 2016 | Dec 3, 2016 |
|
1100 | Increased, cholestasis | prolonged, elevation of serun CCK | Nov 29, 2016 | Dec 3, 2016 |
|
3094 | Alteration, lipid metabolism | General Apoptosis | Oct 18, 2023 | Oct 19, 2023 |
|
1098 | prolonged, elevation of serun CCK | Increased, Cellular proliferation / hyperplasia of acinar cells | Nov 29, 2016 | Dec 3, 2016 |
|
1099 | Increased, Cellular proliferation / hyperplasia of acinar cells | Increased, Pancreatic acinar tumors | Nov 29, 2016 | Dec 3, 2016 |
|
1102 | prepubertal increase, Estrogen receptor (ER) activity | Activation, estrogen receptor alpha | Nov 29, 2016 | Dec 3, 2016 |
|
1103 | Activation, estrogen receptor alpha | Promotion, SIX-1 postive basal-type progenitor cells | Nov 29, 2016 | Dec 3, 2016 |
|
2730 | Activation, estrogen receptor alpha | Impaired, Reproduction | Aug 15, 2022 | Aug 15, 2022 |
|
2666 | Activation, estrogen receptor alpha | Decreased, Gonadotropins | Jun 6, 2022 | Aug 15, 2022 |
|
2665 | Activation, estrogen receptor alpha | Increased, Kisspeptin signalling | Jun 6, 2022 | Aug 15, 2022 |
|
2969 | Activation, estrogen receptor alpha | Epigenetic modification process | Jul 27, 2023 | Jul 27, 2023 |
|
1104 | Promotion, SIX-1 postive basal-type progenitor cells | Proliferation/Clonal Expansion, aberrant basal cells | Nov 29, 2016 | Dec 3, 2016 |
|
1105 | Proliferation/Clonal Expansion, aberrant basal cells | squamous metaplasia, aberrant basal cells | Nov 29, 2016 | Dec 3, 2016 |
|
1106 | squamous metaplasia, aberrant basal cells | Increased, Hyperplasia (glandular epithelial cells of endometrium) | Nov 29, 2016 | Dec 3, 2016 |
|
1107 | Increased, Hyperplasia (glandular epithelial cells of endometrium) | Increased, adenosquamous carcinomas of endometrium | Nov 29, 2016 | Dec 3, 2016 |
|
1108 | Decreased, GnRH pulsatility/release in hypothalamus | Decreased, LH Surge from anterior pituitary | Nov 29, 2016 | Dec 3, 2016 |
|
1109 | Decreased, LH Surge from anterior pituitary | interruption, Ovulation | Nov 29, 2016 | Dec 3, 2016 |
|
1110 | Decreased, LH Surge from anterior pituitary | prolonged, estrus | Nov 29, 2016 | Dec 3, 2016 |
|
1118 | interruption, Ovulation | Increased, circulating estrogen levels | Nov 29, 2016 | Dec 3, 2016 |
|
1111 | prolonged, estrus | Increased, circulating estrogen levels | Nov 29, 2016 | Dec 3, 2016 |
|
1112 | prolonged, estrus | Increased, prolactin exposure | Nov 29, 2016 | Dec 3, 2016 |
|
1113 | Increased, circulating estrogen levels | Hyperplasia, Mammary gland | Nov 29, 2016 | Dec 3, 2016 |
|
1119 | Increased, circulating estrogen levels | Increased, lactotroph hyperplasia and hypertrophy | Nov 29, 2016 | Dec 3, 2016 |
|
3437 | Increased, circulating estrogen levels | Plasma E2, increased | Nov 22, 2024 | Nov 22, 2024 |
|
3439 | Increased, circulating estrogen levels | Increased E2 availability | Nov 22, 2024 | Nov 22, 2024 |
|
2584 | Increased, circulating estrogen levels | Hyperplasia, ovarian stromal cells | Feb 26, 2022 | Mar 2, 2022 | |
2585 | Increased, circulating estrogen levels | Hyperplasia, ovarian epithelium | Feb 26, 2022 | Mar 2, 2022 |
|
1114 | Increased, prolactin exposure | Hyperplasia, Mammary gland | Nov 29, 2016 | Dec 3, 2016 |
|
1115 | Hyperplasia, Mammary gland | Increased, latency period | Nov 29, 2016 | Dec 3, 2016 |
|
1116 | Hyperplasia, Mammary gland | Increased, Adenomas/carcinomas (mammary) | Nov 29, 2016 | Dec 3, 2016 |
|
1117 | Increased, latency period | Increased, Adenomas/carcinomas (mammary) | Nov 29, 2016 | Dec 3, 2016 |
|
1120 | Increased, lactotroph hyperplasia and hypertrophy | Increased, adenomas (pituitary) | Nov 29, 2016 | Dec 3, 2016 |
|
1121 | Decreased, Dopaminergic activity | Increased, prolactin secretion | Nov 29, 2016 | Dec 3, 2016 |
|
1122 | Increased, prolactin secretion | Increased, hyperplasia (mammary gland) | Nov 29, 2016 | Dec 3, 2016 |
|
1123 | Increased, hyperplasia (mammary gland) | Increased, latency period | Nov 29, 2016 | Dec 3, 2016 |
|
1124 | Increased, hyperplasia (mammary gland) | Increased, Adenomas/carcinomas (mammary) | Nov 29, 2016 | Dec 3, 2016 |
|
1125 | persistent, cytotoxicity (pleura or peritoneum) | Increased, inflammation | Nov 29, 2016 | Dec 3, 2016 |
|
3261 | persistent, cytotoxicity (pleura or peritoneum) | Oxidative Stress | Jul 3, 2024 | Jul 3, 2024 |
|
1127 | Increased, inflammation | Increased, secretion of local growth factors | Nov 29, 2016 | Dec 3, 2016 |
|
1130 | Increased, Cell Proliferation (mesothelium) | Increased, mesotheliomas | Nov 29, 2016 | Dec 3, 2016 |
|
1142 | Decreased, Thyroxine (T4) in tissues | Altered, Amphibian metamorphosis | Nov 29, 2016 | Dec 3, 2016 | |
1163 | Decreased, Thyroxine (T4) in tissues | Decreased, Triiodothyronine (T3) in tissues | Nov 29, 2016 | Dec 3, 2016 | |
1132 | Increased, blood uric acid concentration | Occurrence, tophi (urate) deposition | Nov 29, 2016 | Dec 3, 2016 |
|
3263 | Increased, blood uric acid concentration | Oxidative Stress | Jul 3, 2024 | Jul 3, 2024 |
|
1134 | Occurrence, renal proximal tubular necrosis | Increased, blood potassium concentration | Nov 29, 2016 | Dec 3, 2016 |
|
1156 | Occurrence, renal proximal tubular necrosis | Increased, blood uric acid concentration | Nov 29, 2016 | Dec 3, 2016 |
|
2647 | Occurrence, renal proximal tubular necrosis | Occurrence, Kidney toxicity | Apr 8, 2022 | Apr 8, 2022 |
|
1135 | Increased, blood potassium concentration | Occurrence, cardiac arrthymia | Nov 29, 2016 | Dec 3, 2016 | |
1140 | Increased, blood potassium concentration | Occurrence, cardiac arrhythmia | Nov 29, 2016 | Dec 3, 2016 |
|
3403 | Increased, blood potassium concentration | Disruption in action potential generation | Nov 20, 2024 | Nov 20, 2024 |
|
1136 | Occurrence, cardiac arrthymia | Increased Mortality | Nov 29, 2016 | Dec 3, 2016 | |
1133 | Occurrence, tophi (urate) deposition | Occurrence, renal proximal tubular necrosis | Nov 29, 2016 | Dec 3, 2016 |
|
1137 | Inhibition, Cyclooxygenase 1 activity | Decreased, Prostaglandin F2alpha concentration, plasma | Nov 29, 2016 | Dec 3, 2016 |
|
1138 | Decreased, Prostaglandin F2alpha concentration, plasma | Occurrence, renal ischemia | Nov 29, 2016 | Dec 3, 2016 |
|
1139 | Occurrence, renal ischemia | Occurrence, renal proximal tubular necrosis | Nov 29, 2016 | Dec 3, 2016 | |
3265 | Occurrence, renal ischemia | Oxidative Stress | Jul 3, 2024 | Jul 3, 2024 |
|
2854 | Occurrence, cardiac arrhythmia | Increased,Cardiac dysfunction | Jan 29, 2023 | Jan 29, 2023 | |
1141 | Occurrence, cardiac arrhythmia | Increased Mortality | Nov 29, 2016 | Dec 3, 2016 |
|
1145 | Weakened, Colony | Death/Failure, Colony | Nov 29, 2016 | Dec 3, 2016 |
|
1151 | Abnormal, Role change within caste | Weakened, Colony | Nov 29, 2016 | Dec 3, 2016 |
|
1155 | Increased, Deformed Wing Virus levels | Weakened, Colony | Nov 29, 2016 | Dec 3, 2016 |
|
1157 | Increased, Energetic demands and therefore metabolic stress | Abnormal, Foraging activity and behavior | Nov 29, 2016 | Dec 3, 2016 |
|
1161 | Unknown, MIE | Increased, Reactive oxygen species | Nov 29, 2016 | Dec 3, 2016 |
|
2035 | Unknown, MIE | Unknown, | Jan 26, 2020 | Jan 26, 2020 | |
2036 | Unknown, MIE | N/A, Unknown | Jan 26, 2020 | Jan 26, 2020 | |
2033 | Increased, Reactive oxygen species | β-catenin activation | Jan 19, 2020 | Jan 19, 2020 | |
2009 | Increased, Reactive oxygen species | Oxidative Stress | Dec 3, 2019 | Aug 2, 2024 |
|
1696 | Increased, Reactive oxygen species | increased, oncotic necrosis | Nov 14, 2017 | Nov 14, 2017 |
|
2966 | Increased, Reactive oxygen species | Apoptosis | Jul 18, 2023 | Apr 11, 2024 |
|
3092 | Increased, Reactive oxygen species | Decreased, PPAR-gamma activation | Oct 18, 2023 | Oct 19, 2023 |
|
1965 | Increased, Reactive oxygen species | Increased, DNA damage and mutation | Jul 3, 2019 | Jul 3, 2019 |
|
2594 | Increased, Reactive oxygen species | Accumulation, Collagen | Mar 3, 2022 | Mar 3, 2022 | |
2550 | Increased, Reactive oxygen species | Decrease, MMP | Jan 21, 2022 | Jan 21, 2022 |
|
2549 | Increased, Reactive oxygen species | D1 protein deactivation | Jan 21, 2022 | Jan 21, 2022 |
|
2660 | Increased, Reactive oxygen species | Secondary genotoxicity | May 25, 2022 | May 25, 2022 |
|
2328 | Increased, Reactive oxygen species | Increased Sodium-sensitive hypertension | Apr 10, 2021 | Apr 10, 2021 |
|
2324 | Increased, Reactive oxygen species | Increased extracellular matrix deposition | Apr 10, 2021 | Apr 10, 2021 |
|
2320 | Increased, Reactive oxygen species | Increased activation, Nuclear factor kappa B (NF-kB) | Apr 10, 2021 | Apr 10, 2021 |
|
2460 | Increased, Reactive oxygen species | Increase, LPO | Aug 5, 2021 | Apr 11, 2024 |
|
2238 | Decreased, Triiodothyronine (T3) in tissues | Increased, Thyroid-stimulating hormone (TSH) | Dec 9, 2020 | Dec 9, 2020 |
|
2239 | Decreased, Triiodothyronine (T3) in tissues | Altered, TH-dependent gene expression | Dec 9, 2020 | Dec 9, 2020 |
|
1164 | Decreased, Triiodothyronine (T3) in tissues | Altered, Amphibian metamorphosis | Nov 29, 2016 | Dec 3, 2016 |
|
1168 | Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failur | Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) | Nov 29, 2016 | Dec 3, 2016 |
|
1169 | Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) | Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tis | Nov 29, 2016 | Dec 3, 2016 |
|
1165 | Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carbo | Hemostasis, Depletion from blood of fully functional carboxylated clotting factors | Nov 29, 2016 | Dec 3, 2016 |
|
1170 | Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tis | Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction | Nov 29, 2016 | Dec 3, 2016 |
|
1166 | Hemostasis, Depletion from blood of fully functional carboxylated clotting factors | Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failur | Nov 29, 2016 | Dec 3, 2016 |
|
1167 | Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle | Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carbo | Nov 29, 2016 | Dec 3, 2016 |
|
1171 | Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction | Impaired recruitment , Population trajectory | Nov 29, 2016 | Dec 3, 2016 |
|
1175 | Increased, water retention in foot | Increased, foot detachment | Nov 29, 2016 | Dec 3, 2016 |
|
1223 | Increased, water retention in foot | Increased, valve movement | Nov 29, 2016 | Dec 3, 2016 |
|
1182 | Delayed, Sexual maturity | Decreased, Reproductive Success | Nov 29, 2016 | Dec 3, 2016 | |
2635 | Decreased, Reproductive Success | Decrease, Population growth rate | Apr 6, 2022 | Apr 6, 2022 |
|
1173 | Increased, valve movement | Depletion, energy reserves | Nov 29, 2016 | Dec 3, 2016 |
|
1174 | Increased, valve movement | Increased, water retention in foot | Nov 29, 2016 | Dec 3, 2016 |
|
1216 | Increased, valve movement | Increased, water pumping | Nov 29, 2016 | Dec 3, 2016 | |
1227 | Increased, valve movement | Increase, predation | Nov 29, 2016 | Dec 3, 2016 |
|
1320 | Increased, valve movement | induced spawning | Jan 13, 2017 | Jan 13, 2017 |
|
1334 | Increased, valve movement | Induced parturition | Jan 30, 2017 | Jan 30, 2017 |
|
1181 | Depletion, energy reserves | Delayed, Sexual maturity | Nov 29, 2016 | Dec 3, 2016 | |
1185 | Depletion, energy reserves | Increase, predation | Nov 29, 2016 | Dec 3, 2016 |
|
1179 | premature, spawning 1 | Decreased, Reproductive Success | Nov 29, 2016 | Dec 3, 2016 | |
1188 | Decreased, gametogenesis | Decreased, Reproductive Success | Nov 29, 2016 | Dec 3, 2016 | |
1211 | premature, Spawning | Increased, Population | Nov 29, 2016 | Dec 3, 2016 | |
1222 | premature, Spawning | Decreased, Reproductive Success | Nov 29, 2016 | Dec 3, 2016 | |
1193 | increased or inappropriate, mantel display | Decreased, Reproductive Success | Nov 29, 2016 | Dec 3, 2016 | |
1219 | increased or inappropriate, mantel display | Depletion, energy reserves | Nov 29, 2016 | Dec 3, 2016 | |
1220 | increased or inappropriate, mantel display | induced, parturition | Nov 29, 2016 | Dec 3, 2016 | |
1194 | Anticoagulant rodenticide interferes with gamma-carboxyglutamate formation, Inhibition of p | Calcium cannot bind to the hydroxyapatite matrix of bone, Osteocalcin and other bone protei | Nov 29, 2016 | Dec 3, 2016 | |
1195 | Calcium cannot bind to the hydroxyapatite matrix of bone, Osteocalcin and other bone protei | Uncarboxylated osteocalcin not incorporated into bone matrix, decreasing bone strength, Imp | Nov 29, 2016 | Dec 3, 2016 | |
1196 | Uncarboxylated osteocalcin not incorporated into bone matrix, decreasing bone strength, Imp | Osteoporosis and vascular calcification, Bone deterioration | Nov 29, 2016 | Dec 3, 2016 | |
1197 | Inhibition, Iodotyrosine deiodinase (IYD) | Thyroidal Iodide, Decreased | Nov 29, 2016 | Dec 3, 2016 |
|
2476 | Inhibition, Iodotyrosine deiodinase (IYD) | T4 in serum, Decreased | Sep 9, 2021 | Sep 9, 2021 |
|
1200 | Inhibition, Deiodinase 3 | Increased, Triiodothyronine (T3) in tissues | Nov 29, 2016 | Dec 3, 2016 |
|
1201 | Increased, Triiodothyronine (T3) in tissues | Altered, Amphibian metamorphosis | Nov 29, 2016 | Dec 3, 2016 | |
2243 | Increased, Triiodothyronine (T3) in tissues | Altered, TH-dependent gene expression | Dec 9, 2020 | Dec 9, 2020 |
|
1202 | Inhibition, Pendrin | TH synthesis, Decreased | Nov 29, 2016 | Dec 3, 2016 |
|
1203 | Inhibition, Dual oxidase | TH synthesis, Decreased | Nov 29, 2016 | Dec 3, 2016 |
|
1204 | Activation, Hepatic nuclear receptor(s) | Increased, Hepatic thyroid hormone uptake/transport | Nov 29, 2016 | Dec 3, 2016 |
|
1205 | Activation, Hepatic nuclear receptor(s) | Induction, Upregulation of glucuronyltransferase activity | Nov 29, 2016 | Dec 3, 2016 |
|
1206 | Increased, Hepatic thyroid hormone uptake/transport | Increase, Biliary excretion TH glucuronide | Nov 29, 2016 | Dec 3, 2016 | |
2237 | Increased, Hepatic thyroid hormone uptake/transport | T4 in serum, Decreased | Dec 9, 2020 | Dec 9, 2020 |
|
2479 | Increased, Hepatic thyroid hormone uptake/transport | Increased, Clearance of thyroxine from serum | Sep 10, 2021 | Sep 10, 2021 |
|
1214 | Increased, mantel display | Increased, Reproductive Success | Nov 29, 2016 | Dec 3, 2016 | |
1213 | Increased, oocyte maturation | Increased, Reproductive Success | Nov 29, 2016 | Dec 3, 2016 | |
1328 | Increased, oocyte maturation | induced spawning | Jan 17, 2017 | Jan 17, 2017 |
|
1210 | Increased, cilia movement | premature, Spawning | Nov 29, 2016 | Dec 3, 2016 | |
1329 | Increased, cilia movement | induced spawning | Jan 17, 2017 | Jan 17, 2017 | |
1215 | Increased, Reproductive Success | Increased, Population | Nov 29, 2016 | Dec 3, 2016 |
|
1224 | Increased, water pumping | Increased, water retention in foot | Nov 29, 2016 | Dec 3, 2016 | |
1225 | Increased, water pumping | premature, Spawning | Nov 29, 2016 | Dec 3, 2016 | |
1226 | Increased, water pumping | induced, parturition | Nov 29, 2016 | Dec 3, 2016 | |
1221 | induced, parturition | Decreased, Reproductive Success | Nov 29, 2016 | Dec 3, 2016 | |
1230 | Increase, Phenotypic enzyme activity | Increase, cell proliferation (hepatocytes) | Nov 29, 2016 | Dec 31, 2020 |
|
1231 | Increase, Phenotypic enzyme activity | Increase, Clonal Expansion of Altered Hepatic Foci | Nov 29, 2016 | Dec 3, 2016 | |
1232 | Increase, Clonal Expansion of Altered Hepatic Foci | Increase, hepatocellular adenomas and carcinomas | Nov 29, 2016 | Dec 3, 2016 |
|
1238 | Increased activation, Nuclear factor kappa B (NF-kB) | Increase, Phenotypic enzyme activity | Nov 29, 2016 | Dec 3, 2016 | |
2612 | Increased activation, Nuclear factor kappa B (NF-kB) | Antagonism, Estrogen receptor | Mar 22, 2022 | Aug 27, 2023 |
|
2432 | Increased activation, Nuclear factor kappa B (NF-kB) | Increased pro-inflammatory mediators | Jul 8, 2021 | Jul 8, 2021 |
|
2431 | Increased activation, Nuclear factor kappa B (NF-kB) | Release, Cytokine | Jul 8, 2021 | Jul 8, 2021 |
|
2309 | Increased activation, Nuclear factor kappa B (NF-kB) | Increased proinflammatory mediators | Mar 30, 2021 | Mar 30, 2021 |
|
1241 | Increase, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids | Peptide Oxidation | Nov 29, 2016 | Dec 3, 2016 | |
1235 | Activation, NADPH Oxidase | Peptide Oxidation | Nov 29, 2016 | Dec 3, 2016 | |
1360 | Activation, NADPH Oxidase | ROS formation | Feb 15, 2017 | Feb 15, 2017 |
|
1234 | Increase, Genes involved in fatty acid oxidation | Peptide Oxidation | Nov 29, 2016 | Dec 3, 2016 | |
1240 | Increase, Genes involved in fatty acid oxidation | Increase, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids | Nov 29, 2016 | Dec 3, 2016 | |
1243 | Decreased, sodium conductance 2 | Decreased, Ionotropic GABA receptor chloride channel conductance | Nov 29, 2016 | Dec 3, 2016 | |
1244 | Decreased, sodium conductance 2 | Decreased, GABA release | Nov 29, 2016 | Dec 3, 2016 |
|
1245 | Decreased, GABA release | Decreased, Chloride conductance | Nov 29, 2016 | Dec 3, 2016 | |
1246 | Activation, Estrogen receptor | Increased, ER binding to DNA (classical pathway) | Nov 29, 2016 | Dec 3, 2016 |
|
1249 | Activation, Estrogen receptor | Increased, ER binding to T.F. to DNA (non-classical pathway) | Nov 29, 2016 | Dec 3, 2016 |
|
1294 | Activation, Estrogen receptor | Increased, Non-genomic signaling | Nov 29, 2016 | Dec 3, 2016 |
|
1307 | Activation, Estrogen receptor | Increased, Second Messenger Production | Nov 29, 2016 | Dec 3, 2016 |
|
1247 | Increase, Cell Proliferation (Epithelial Cells) | Increased, Ductal Hyperplasia | Nov 29, 2016 | Dec 3, 2016 |
|
1907 | Increase, Cell Proliferation (Epithelial Cells) | Increase, Mutations | May 8, 2019 | May 8, 2019 |
|
1248 | Decreased, Apoptosis (Epithelial Cells) | Increased, Ductal Hyperplasia | Nov 29, 2016 | Dec 3, 2016 |
|
2914 | Decreased, Apoptosis (Epithelial Cells) | Alterations, Cellular proliferation / hyperplasia | May 11, 2023 | May 11, 2023 |
|
1250 | Increased, ER binding to DNA (classical pathway) | Increase, Cell Proliferation (Epithelial Cells) | Nov 29, 2016 | Dec 3, 2016 |
|
1296 | Increased, ER binding to DNA (classical pathway) | Altered, Gene Expression | Nov 29, 2016 | Dec 3, 2016 |
|
1251 | Increased, ER binding to T.F. to DNA (non-classical pathway) | Increase, Cell Proliferation (Epithelial Cells) | Nov 29, 2016 | Dec 3, 2016 |
|
1297 | Increased, ER binding to T.F. to DNA (non-classical pathway) | Altered, Gene Expression | Nov 29, 2016 | Dec 3, 2016 |
|
1266 | Increased, Proliferation (Endothelial cells) | Increased, Angiogenesis | Nov 29, 2016 | Dec 20, 2022 |
|
1267 | Increased, Migration (Endothelial Cells) | Increased, Angiogenesis | Nov 29, 2016 | Dec 20, 2022 |
|
2575 | Increased, Migration (Endothelial Cells) | Increase, angiogenesis | Feb 15, 2022 | Mar 5, 2024 |
|
1295 | Increased, Non-genomic signaling | Increased, ER binding to T.F. to DNA (non-classical pathway) | Nov 29, 2016 | Dec 3, 2016 |
|
1302 | Increased, Non-genomic signaling | Altered, Gene Expression | Nov 29, 2016 | Dec 3, 2016 |
|
1252 | Increased, Ductal Hyperplasia | N/A, Breast Cancer | Nov 29, 2016 | May 8, 2019 |
|
1301 | Increase, DNA Damage | Altered, Gene Expression | Nov 29, 2016 | Dec 3, 2016 |
|
1468 | Increase, DNA Damage | Increase, Apoptosis | Apr 15, 2017 | Apr 15, 2017 |
|
2338 | Increase, DNA Damage | Increase, Programmed cell death | Apr 11, 2021 | Apr 11, 2021 |
|
2382 | Increase, DNA Damage | Increase, Oocyte apoptosis | May 12, 2021 | May 12, 2021 |
|
2381 | Increase, DNA Damage | Altered, Meiotic chromosome dynamics | May 12, 2021 | May 12, 2021 |
|
1899 | Increase, DNA Damage | Increase mutations | May 7, 2019 | May 7, 2019 | |
1898 | Increase, DNA Damage | Tissue resident cell activation | May 7, 2019 | May 10, 2019 |
|
1897 | Increase, DNA Damage | Increase, Mutations | May 7, 2019 | May 8, 2019 |
|
2595 | Increase, DNA Damage | Activation of TP53 | Mar 9, 2022 | Mar 9, 2022 |
|
2622 | Increase, DNA Damage | Decreased spermatogenesis | Mar 28, 2022 | Mar 28, 2022 |
|
2790 | Increase, DNA Damage | Cell cycle, disrupted | Oct 25, 2022 | Oct 25, 2022 |
|
3138 | Increased, Invasion | Metastasis, Breast Cancer | Mar 5, 2024 | Mar 5, 2024 |
|
2576 | Increased, Invasion | N/A, Breast Cancer | Feb 15, 2022 | Feb 15, 2022 | |
3376 | Activation, Macrophages | Foam cell formation | Oct 30, 2024 | Oct 30, 2024 |
|
1253 | Binding, Immunophilins | Inhibition, Calcineurin Activity | Nov 29, 2016 | Oct 25, 2017 | |
1255 | Suppression, IL-2 and IL-4 production | Interference, nuclear localization of NFAT | Nov 29, 2016 | Dec 3, 2016 | |
1510 | Suppression, IL-2 and IL-4 production | Impairment, T-cell dependent antibody response | May 19, 2017 | Jun 27, 2021 |
|
1258 | Suppression, Suppression of production of cytotoxic T-cells | Impairment, T-cell dependent antibody response | Nov 29, 2016 | Dec 3, 2016 | |
1260 | Suppression, Suppression of production of cytotoxic T-cells | Impairment of TDAR | Nov 29, 2016 | Dec 3, 2016 | |
1259 | Suppression, Suppression of T-cell dependent antibody production | Impairment of TDAR | Nov 29, 2016 | Dec 3, 2016 | |
1261 | Activation, Juvenile hormone receptor | Induction, Doublesex1 gene | Nov 29, 2016 | Dec 3, 2016 |
|
1262 | Induction, Doublesex1 gene | Induction, Male reproductive tract | Nov 29, 2016 | Dec 3, 2016 |
|
1264 | Increased, Male offspring | Decline, Population | Nov 29, 2016 | Dec 3, 2016 |
|
1263 | Induction, Male reproductive tract | Increased, Male offspring | Nov 29, 2016 | Dec 3, 2016 |
|
1269 | Altered expression of hepatic CAR-dependent genes | Increase, cell proliferation (hepatocytes) | Nov 29, 2016 | Dec 21, 2018 |
|
1271 | TRPA1 activation, TRPA1 Receptor | Opening of calcium channel, Calcium influx | Nov 29, 2016 | Nov 29, 2016 |
|
1284 | TRPA1 activation, TRPA1 Receptor | Non-neuronal production of IL-8/CXCL1, Epithelial irritation | Nov 29, 2016 | Dec 3, 2016 | |
1576 | TRPA1 activation, TRPA1 Receptor | Generation of novel epitopes , Antigen presentation | Jun 23, 2017 | Jun 23, 2017 | |
1273 | Sensory Airway Irritation | Cough, Dyspnea, Sneezing, Acute respiratory effect | Nov 29, 2016 | Dec 3, 2016 | |
1272 | Opening of calcium channel, Calcium influx | Sensory Airway Irritation | Nov 29, 2016 | Dec 3, 2016 | |
1274 | Opening of calcium channel, Calcium influx | Excitation, Trigeminal nerve excitation | Nov 29, 2016 | Dec 3, 2016 |
|
1280 | Opening of calcium channel, Calcium influx | SP (Substance P) release, Local increase of SP | Nov 29, 2016 | Nov 29, 2016 | |
1275 | Excitation, Trigeminal nerve excitation | Cough, Dyspnea, Sneezing, Acute respiratory effect | Nov 29, 2016 | Dec 3, 2016 | |
1276 | Excitation, Trigeminal nerve excitation | Increased Airway Hyper-responsiveness,Cough, Dyspnea | Nov 29, 2016 | Dec 3, 2016 | |
1575 | Excitation, Trigeminal nerve excitation | SP (Substance P) release, Local increase of SP | Jun 23, 2017 | Jun 23, 2017 |
|
1578 | Excitation, Trigeminal nerve excitation | Increased CGRP | Jun 23, 2017 | Jun 23, 2017 |
|
1582 | Excitation, Trigeminal nerve excitation | Irritation induced sneezing | Jun 23, 2017 | Jun 23, 2017 |
|
1583 | Excitation, Trigeminal nerve excitation | Increased NKA | Jun 23, 2017 | Jun 23, 2017 |
|
1574 | SP (Substance P) release, Local increase of SP | Increased Airway Hyper-responsiveness,Cough, Dyspnea | Jun 23, 2017 | Jun 23, 2017 | |
1577 | SP (Substance P) release, Local increase of SP | Leukocyte infiltration | Jun 23, 2017 | Jun 23, 2017 | |
1279 | SP (Substance P) release, Local increase of SP | Non-neuronal production of TNF, Epithelial irritation | Nov 29, 2016 | Nov 29, 2016 | |
1772 | SP (Substance P) release, Local increase of SP | Respiratory irritability | Sep 24, 2018 | Sep 24, 2018 |
|
1771 | Increased Airway Hyper-responsiveness,Cough, Dyspnea | Respiratory irritability | Sep 24, 2018 | Sep 24, 2018 | |
1277 | Non-neuronal production of TNF, Epithelial irritation | Leukocyte infiltration | Nov 29, 2016 | Dec 3, 2016 | |
1288 | Non-neuronal production of TNF, Epithelial irritation | Opening of calcium channel, Calcium influx | Nov 29, 2016 | Dec 3, 2016 | |
1278 | Leukocyte infiltration | Respiratory irritability | Nov 29, 2016 | Dec 3, 2016 | |
1290 | Leukocyte infiltration | Sensitization, Immune system | Nov 29, 2016 | Dec 3, 2016 | |
1770 | Respiratory irritability | Increased Airway Hyper-responsiveness,Cough, Dyspnea | Sep 24, 2018 | Sep 24, 2018 |
|
1281 | TRPV1 activation, TRPV1 | Opening of calcium channel, Calcium influx | Nov 29, 2016 | Nov 29, 2016 | |
1282 | Oxidization of biomolecules, Lipid bilayer and cellular proteins | TRPA1 activation, TRPA1 Receptor | Nov 29, 2016 | Dec 3, 2016 | |
1285 | Oxidization of biomolecules, Lipid bilayer and cellular proteins | Generation of novel epitopes , Antigen presentation | Nov 29, 2016 | Dec 3, 2016 | |
1286 | Oxidization of biomolecules, Lipid bilayer and cellular proteins | Production of nerve growth factor , Epithelial irritation | Nov 29, 2016 | Dec 3, 2016 | |
1283 | Production of nerve growth factor , Epithelial irritation | SP (Substance P) release, Local increase of SP | Nov 29, 2016 | Dec 3, 2016 | |
1287 | Non-neuronal production of IL-8/CXCL1, Epithelial irritation | Opening of calcium channel, Calcium influx | Nov 29, 2016 | Dec 3, 2016 | |
1289 | Generation of novel epitopes , Antigen presentation | Sensitization, Immune system | Nov 29, 2016 | Dec 3, 2016 | |
1291 | Oxidation | Generation of novel epitopes , Antigen presentation | Nov 29, 2016 | Dec 3, 2016 | |
1292 | Oxidation | TRPA1 activation, TRPA1 Receptor | Nov 29, 2016 | Dec 3, 2016 | |
1293 | Oxidation | Production of nerve growth factor , Epithelial irritation | Nov 29, 2016 | Dec 3, 2016 | |
1298 | Altered, Gene Expression | Altered, Protein Production | Nov 29, 2016 | Dec 3, 2016 |
|
1807 | Altered, Gene Expression | Altered differentiation | Dec 20, 2018 | Dec 20, 2018 |
|
3266 | Altered, Protein Production | Oxidative Stress | Jul 4, 2024 | Jul 4, 2024 |
|
1303 | Altered, Protein Production | Increased, Proliferation (Endothelial cells) | Nov 29, 2016 | Dec 3, 2016 |
|
1304 | Altered, Protein Production | Decreased, Apoptosis (Epithelial Cells) | Nov 29, 2016 | Dec 3, 2016 |
|
1305 | Altered, Protein Production | Increased, Motility | Nov 29, 2016 | Dec 3, 2016 |
|
1306 | Increased, Motility | Increased, Invasion | Nov 29, 2016 | Feb 29, 2024 |
|
1308 | Increased, Second Messenger Production | Increased, Non-genomic signaling | Nov 29, 2016 | Dec 3, 2016 |
|
1310 | Altered, Ca2+-calmodulin activated signal transduction | Impairment, Learning and memory | Nov 29, 2016 | Dec 3, 2016 |
|
1314 | Chronic, Mucus hypersecretion | Decreased lung function | Nov 29, 2016 | Aug 30, 2021 | |
1330 | Binding, topoisomerase II | MLL translocation | Jan 20, 2017 | Apr 26, 2017 | |
1634 | Binding, topoisomerase II | Increase, DSB | Aug 2, 2017 | Aug 1, 2022 |
|
1331 | MLL translocation | IFL | Jan 20, 2017 | Aug 1, 2022 |
|
1324 | induced spawning | Decreased, Reproductive Success | Jan 13, 2017 | Jan 13, 2017 | |
1325 | induced spawning | Increased, Reproductive Success | Jan 13, 2017 | Jan 13, 2017 |
|
1322 | increased mantel display | Induced parturition | Jan 13, 2017 | Jan 13, 2017 |
|
1323 | Induced parturition | Decreased, Reproductive Success | Jan 13, 2017 | Jan 13, 2017 |
|
1326 | Induced parturition | Increased, Reproductive Success | Jan 13, 2017 | Jan 13, 2017 |
|
3147 | Decompartmentalization | Mitochondrial dysfunction | Mar 13, 2024 | Mar 13, 2024 |
|
3148 | narcosis | Mitochondrial dysfunction | Mar 13, 2024 | Mar 13, 2024 |
|
3145 | Direct mitochondrial inhibition | Mitochondrial dysfunction | Mar 13, 2024 | Mar 13, 2024 |
|
3257 | Apoptosis | Neuroinflammation | Jun 19, 2024 | Jun 19, 2024 |
|
3251 | Apoptosis | Disruption, neurotransmitter release | Jun 19, 2024 | Jun 19, 2024 |
|
3250 | Apoptosis | Aberrant, synaptic formation and plasticity | Jun 19, 2024 | Jun 19, 2024 |
|
3327 | Apoptosis | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | Jul 26, 2024 | Jul 26, 2024 |
|
2967 | Apoptosis | N/A, Neurodegeneration | Jul 18, 2023 | Apr 11, 2024 |
|
3106 | Apoptosis | decline, neural progenitor cells | Jan 10, 2024 | Jan 10, 2024 |
|
1867 | Apoptosis | Activation, hepatic stellate cells | Mar 6, 2019 | Mar 6, 2019 |
|
1869 | Apoptosis | Liver Injury | Mar 6, 2019 | Mar 6, 2019 |
|
2191 | Apoptosis | Increase, Tissue/organ damage | Nov 2, 2020 | Nov 2, 2020 | |
2792 | Apoptosis | Decrease, outgrowth | Oct 27, 2022 | Apr 11, 2023 |
|
2675 | Apoptosis | Emphysema | Jun 17, 2022 | Jun 17, 2022 |
|
1368 | Apoptosis | Reproductive failure | Feb 15, 2017 | Feb 15, 2017 |
|
1735 | Apoptosis | Spermatocyte depletion | May 22, 2018 | Jul 28, 2021 |
|
1713 | Apoptosis | Testicular atrophy | Jan 21, 2018 | Jan 21, 2018 | |
2577 | Apoptosis | tumor growth | Feb 15, 2022 | Mar 5, 2024 |
|
1344 | Increase, E75b expression | Increase, Ftz-f1 expression | Feb 9, 2017 | Feb 9, 2017 |
|
1345 | Increase, Ftz-f1 expression | Decrease, Circulating ETH | Feb 9, 2017 | Feb 9, 2017 |
|
1347 | Decrease, Circulating CCAP | Decrease, Ecdysis motoneuron bursts | Feb 9, 2017 | Feb 9, 2017 |
|
1348 | Decrease, Ecdysis motoneuron bursts | Decrease, Excitatory postsynaptic potential | Feb 9, 2017 | Feb 9, 2017 |
|
1349 | Decrease, Excitatory postsynaptic potential | Decrease, Abdominal muscle contraction | Feb 9, 2017 | Feb 9, 2017 |
|
1351 | Increase, COX-2 expression | Altered, Cardiovascular development/function | Feb 9, 2017 | Mar 28, 2018 |
|
1353 | Inactivation of PPARγ | Activation of TGF-β signaling | Feb 15, 2017 | Feb 15, 2017 |
|
2156 | Inactivation of PPARγ | Activation, TGF-beta pathway | Jul 9, 2020 | Jul 9, 2020 |
|
1354 | Activation of TGF-β signaling | Differentiation of Myofibroblast | Feb 15, 2017 | Feb 15, 2017 | |
1355 | Activation of TGF-β signaling | Expression of Collagen | Feb 15, 2017 | Feb 15, 2017 | |
1721 | Activation of TGF-β signaling | Increase, Inflammation | Mar 18, 2018 | Mar 18, 2018 |
|
1723 | Activation of TGF-β signaling | EMT | Mar 18, 2018 | Mar 18, 2018 | |
1356 | Differentiation of Myofibroblast | Production of α-smooth muscle actin | Feb 15, 2017 | Feb 15, 2017 | |
1357 | Expression of Collagen | Collagen Deposition | Feb 15, 2017 | Feb 15, 2017 | |
1358 | Production of α-smooth muscle actin | Lung fibrosis | Feb 15, 2017 | Feb 15, 2017 | |
1359 | Collagen Deposition | Lung fibrosis | Feb 15, 2017 | Feb 15, 2017 |
|
1628 | Collagen Deposition | Accumulation, Collagen | Jul 26, 2017 | Jul 26, 2017 | |
1361 | ROS formation | Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK | Feb 15, 2017 | Feb 15, 2017 |
|
1362 | Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK | Increased, DNA Damage-Repair | Feb 15, 2017 | Feb 15, 2017 |
|
1364 | Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK | Activation, HIF-1 | Feb 15, 2017 | Feb 15, 2017 |
|
3166 | Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK | Mitochondrial dysfunction | Mar 14, 2024 | Mar 14, 2024 |
|
1365 | Activation, HIF-1 | Apoptosis | Feb 15, 2017 | Feb 15, 2017 |
|
1366 | Increased, DNA Damage-Repair | Apoptosis | Feb 15, 2017 | Feb 15, 2017 |
|
1369 | Activation, JAK/STAT pathway | Activation, TGF-beta pathway | Feb 15, 2017 | Feb 15, 2017 |
|
1370 | Activation, TGF-beta pathway | Reproductive failure | Feb 15, 2017 | Feb 15, 2017 |
|
2153 | Activation, TGF-beta pathway | EMT | Jul 9, 2020 | Jul 9, 2020 |
|
1371 | Up Regulation, SREBF2 | Up Regulation, Unsaturated fatty acid | Feb 15, 2017 | Feb 15, 2017 |
|
1372 | Up Regulation, Unsaturated fatty acid | Perturbation of cholesterol | Feb 15, 2017 | Feb 15, 2017 |
|
1373 | Down Regulation, GSS and GSTs gene | Glutathione synthesis | Feb 15, 2017 | Feb 15, 2017 |
|
1376 | Down Regulation, GSS and GSTs gene | Glutathione homeostasis | Feb 15, 2017 | Feb 15, 2017 |
|
1374 | Glutathione synthesis | Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene | Feb 15, 2017 | Feb 15, 2017 |
|
1375 | Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene | Perturbation of cholesterol | Feb 15, 2017 | Feb 15, 2017 |
|
1377 | Perturbation of cholesterol | Hepatotoxicity | Feb 15, 2017 | Feb 15, 2017 |
|
1378 | Glutathione homeostasis | Hepatotoxicity | Feb 15, 2017 | Feb 15, 2017 |
|
1380 | Activation, JNK | Activation, FOXO | Feb 15, 2017 | Feb 15, 2017 |
|
2149 | Activation, JNK | AP-1 activation | Jul 9, 2020 | Jul 9, 2020 |
|
2150 | Activation, JNK | Pin-1 activation | Jul 9, 2020 | Jul 9, 2020 |
|
1381 | Activation, FOXO | Inhibition, Wnt pathway | Feb 15, 2017 | Feb 15, 2017 |
|
1382 | Inhibition, Wnt pathway | Defect of Embryogenesis | Feb 15, 2017 | Feb 15, 2017 |
|
1383 | Defect of Embryogenesis | Reproductive failure | Feb 15, 2017 | Feb 15, 2017 |
|
1390 | Increase, insulin | Activation, insulin receptor | Apr 12, 2017 | Apr 12, 2017 | |
1391 | Activation, insulin receptor | Activation, mTORC2 | Apr 12, 2017 | Apr 12, 2017 | |
1392 | Activation, mTORC2 | Activation, AKT | Apr 12, 2017 | Apr 12, 2017 | |
1393 | Activation, mTORC2 | Activation, mTORC1 | Apr 12, 2017 | Apr 12, 2017 | |
1394 | Activation, AKT | Activation, SREBP-1 | Apr 12, 2017 | Apr 12, 2017 | |
1398 | Activation, AKT | Activation, mTORC1 | Apr 12, 2017 | Apr 12, 2017 | |
1400 | Activation, AKT | Activation, L-FABP | Apr 12, 2017 | Apr 12, 2017 | |
1395 | Activation, mTORC1 | Activation, L-FABP | Apr 12, 2017 | Apr 12, 2017 | |
1396 | Activation, mTORC1 | Activation, HSD17B4 | Apr 12, 2017 | Apr 12, 2017 | |
1399 | Activation, mTORC1 | Activation, SREBP-1 | Apr 12, 2017 | Apr 12, 2017 | |
1397 | Activation, SREBP-1 | Activation, FXR | Apr 12, 2017 | Apr 12, 2017 | |
1403 | Activation, SREBP-1 | Activation, SCD-1 | Apr 12, 2017 | Apr 12, 2017 | |
1401 | Activation, L-FABP | Increase, cytosolic fatty acid | Apr 12, 2017 | Apr 12, 2017 | |
1423 | Activation, L-FABP | demethylation, PPARg promoter | Apr 13, 2017 | Apr 13, 2017 | |
1411 | Activation, HSD17B4 | Inhibition, Mitochondrial fatty acid beta-oxidation | Apr 12, 2017 | Apr 12, 2017 | |
1415 | Activation, HSD17B4 | Increase, Fatty acid β-oxidation | Apr 13, 2017 | Apr 13, 2017 | |
1407 | Activation, FXR | Activation, SHP | Apr 12, 2017 | Apr 12, 2017 | |
1408 | Activation, FXR | Activation, PPARα | Apr 12, 2017 | Apr 12, 2017 | |
1693 | Increase, cytosolic fatty acid | steatohepatitis | Nov 13, 2017 | Nov 13, 2017 | |
1694 | Increase, cytosolic fatty acid | Increased, Liver Steatosis | Nov 14, 2017 | Nov 14, 2017 |
|
1405 | Increased, lipogenesis | Increase, cytosolic fatty acid | Apr 12, 2017 | Apr 12, 2017 | |
1413 | Inhibition, LXR | Inhibition, PPAR alpha | Apr 12, 2017 | Apr 12, 2017 | |
1421 | Activation, aPKC | Activation, SREBP-1 | Apr 13, 2017 | Apr 13, 2017 | |
1418 | Activation, PI3K | Activation, AKT | Apr 13, 2017 | Apr 13, 2017 | |
1419 | Activation, PI3K | Activation, L-FABP | Apr 13, 2017 | Apr 13, 2017 | |
1420 | Activation, PI3K | Activation, aPKC | Apr 13, 2017 | Apr 13, 2017 | |
1417 | Increase, Fatty acid β-oxidation | Decrease, cytosolic fatty acid | Apr 13, 2017 | Apr 13, 2017 | |
1425 | Activation, LRH-1 | Activation, FAS | Apr 13, 2017 | Apr 13, 2017 | |
1520 | Inhibit, serotonin transporter activity | Decreased, serotonin transporter activity | May 30, 2017 | May 30, 2017 | |
1426 | Decreased, serotonin transporter activity | Increased, intracellular sodium (Na+) | Apr 14, 2017 | Apr 14, 2017 |
|
1427 | Decreased, serotonin transporter activity | Increased, intracellular chloride (Cl-) | Apr 14, 2017 | Apr 14, 2017 |
|
1428 | Decreased, serotonin transporter activity | Decreased, extracellular Na+ | Apr 14, 2017 | Apr 14, 2017 |
|
1429 | Decreased, serotonin transporter activity | Decreased, extracellular chloride (Cl-) | Apr 14, 2017 | Apr 14, 2017 |
|
1430 | Decreased, serotonin transporter activity | Increased, extracellular serotonin | Apr 14, 2017 | Apr 14, 2017 |
|
1431 | Decreased, serotonin transporter activity | Decreased, intracellular serotonin | Apr 14, 2017 | Apr 14, 2017 |
|
1521 | Increased, extracellular serotonin | Decreased, extracellular serotonin | May 30, 2017 | May 30, 2017 | |
1529 | Increased, extracellular serotonin | Decreased, 5-HT3 | Jun 1, 2017 | Jun 1, 2017 |
|
1531 | Increased, extracellular serotonin | Activation, 5-HT2A | Jun 2, 2017 | Jun 2, 2017 |
|
1455 | Increased, intracellular sodium (Na+) | Activated, voltage-gated sodium channel | Apr 14, 2017 | Apr 14, 2017 |
|
3424 | Increased, intracellular sodium (Na+) | Impaired Sodium-Calcium Exchange | Nov 21, 2024 | Nov 21, 2024 |
|
1465 | Increased, intracellular chloride (Cl-) | Inactive, membrane depolarization | Apr 14, 2017 | Apr 14, 2017 |
|
1432 | Decreased, intracellular serotonin | Decreased, packaged serotonin | Apr 14, 2017 | Apr 14, 2017 |
|
1433 | Decreased, packaged serotonin | Decreased, synaptic release | Apr 14, 2017 | Apr 14, 2017 |
|
1434 | Decreased, synaptic release | Decreased, extracellular serotonin | Apr 14, 2017 | Apr 14, 2017 |
|
1445 | Increased, 5-HT3 | Increased, seizure | Apr 14, 2017 | Apr 14, 2017 |
|
1446 | Inactivated, 5-HTR | Reduce expression, BDNF | Apr 14, 2017 | Apr 14, 2017 |
|
1511 | Inactivated, 5-HTR | Reduced, BDNF | May 30, 2017 | May 30, 2017 |
|
1447 | Reduce expression, BDNF | Decreased, neuroplasticity | Apr 14, 2017 | Apr 14, 2017 |
|
1448 | Decreased, neuroplasticity | Increased, agitation | Apr 14, 2017 | Apr 14, 2017 |
|
1449 | Decreased, neuroplasticity | Increased, depression | Apr 14, 2017 | Apr 14, 2017 |
|
1450 | Increase, cortisone | Activation, Glucocorticoid Receptor | Apr 14, 2017 | Apr 14, 2017 |
|
1523 | Reduced, BDNF | Decreased, neuroplasticity | May 31, 2017 | May 31, 2017 |
|
1438 | Activation, 5-HT2A | Activate, PLC | Apr 14, 2017 | Apr 14, 2017 |
|
1439 | Activate, PLC | Increase, inositol triphosphate | Apr 14, 2017 | Apr 14, 2017 |
|
1440 | Increase, inositol triphosphate | Increase, intracellular calcium | Apr 14, 2017 | Apr 14, 2017 |
|
1441 | Increase, intracellular calcium | Activate, calmodulin | Apr 14, 2017 | Apr 14, 2017 |
|
3140 | Increase, intracellular calcium | Mitochondrial dysfunction | Mar 6, 2024 | Apr 11, 2024 |
|
2954 | Increase, intracellular calcium | Disruption, neurotransmitter release | Jun 27, 2023 | Apr 11, 2024 |
|
2968 | Increase, intracellular calcium | Apoptosis | Jul 18, 2023 | Apr 11, 2024 |
|
1442 | Activate, calmodulin | Increase, myosin light chain phosphorylation | Apr 14, 2017 | Apr 14, 2017 |
|
1443 | Increase, myosin light chain phosphorylation | Increase, vascular smooth muscle contraction | Apr 14, 2017 | Apr 14, 2017 |
|
1444 | Increase, vascular smooth muscle contraction | Increase, hypertension | Apr 14, 2017 | Apr 14, 2017 |
|
1581 | Increase, hypertension | Respiratory irritability | Jun 23, 2017 | Jun 23, 2017 | |
1550 | Increased, seizure | Increased, epilepsy | Jun 2, 2017 | Jun 2, 2017 |
|
1519 | Decreased, extracellular serotonin | Decreased, synaptic release | May 30, 2017 | May 30, 2017 | |
1435 | Decreased, extracellular serotonin | Increased, 5-HT3 | Apr 14, 2017 | Apr 14, 2017 |
|
1436 | Decreased, extracellular serotonin | Inactivated, 5-HTR | Apr 14, 2017 | Apr 14, 2017 |
|
1437 | Decreased, extracellular serotonin | Activation, 5-HT2A | Apr 14, 2017 | Apr 14, 2017 |
|
1460 | Increase, seizure | Increased, epilepsy | Apr 14, 2017 | Apr 14, 2017 |
|
1452 | Activated, presynaptic neuron 1 | Increased, glutamate | Apr 14, 2017 | Apr 14, 2017 |
|
3086 | Activated, presynaptic neuron 1 | Activation, Glutamate-gated chloride channels | Oct 17, 2023 | Oct 17, 2023 |
|
3088 | Activated, presynaptic neuron 1 | Decreased, Ionotropic GABA receptor chloride channel conductance | Oct 17, 2023 | Oct 17, 2023 |
|
2861 | Increased, glutamate | Microglia activation | Apr 3, 2023 | Apr 3, 2023 |
|
2868 | Increased, glutamate | decreased, Bcl-2 | Apr 4, 2023 | Apr 4, 2023 |
|
2869 | Increased, glutamate | increased, Bax | Apr 4, 2023 | Apr 4, 2023 |
|
1453 | Increased, glutamate | Activated, NMDA receptor | Apr 14, 2017 | Apr 14, 2017 |
|
1859 | Increased, glutamate | Overactivation, NMDARs | Feb 13, 2019 | Sep 3, 2023 |
|
1454 | Activated, NMDA receptor | Increased, intracellular sodium (Na+) | Apr 14, 2017 | Apr 14, 2017 |
|
1457 | Activated, voltage-gated sodium channel | Activated, membrane depolarization | Apr 14, 2017 | Apr 14, 2017 |
|
2605 | Binding to VGSC | Altered kinetics of sodium channel | Mar 21, 2022 | Jul 31, 2024 |
|
1456 | Treat, carbamazepine | Binding to VGSC | Apr 14, 2017 | Apr 14, 2017 |
|
1458 | Activated, membrane depolarization | Increased, hippocampal hyperdepolarization | Apr 14, 2017 | Apr 14, 2017 |
|
1463 | Increased, RDX dose | Activate, GABA-A receptor | Apr 14, 2017 | Apr 14, 2017 |
|
1555 | Increased, RDX dose | Reduced, GABA-A receptor activation | Jun 2, 2017 | Jun 2, 2017 |
|
1464 | Activate, GABA-A receptor | Increased, intracellular chloride (Cl-) | Apr 14, 2017 | Apr 14, 2017 |
|
1461 | Activate, presynaptic neuron 2 | Increase, GABA | Apr 14, 2017 | Apr 14, 2017 |
|
1462 | Increase, GABA | Activate, GABA-A receptor | Apr 14, 2017 | Apr 14, 2017 |
|
1459 | Increased, hippocampal hyperdepolarization | Increase, seizure | Apr 14, 2017 | Apr 14, 2017 |
|
1549 | Increased, hippocampal hyperdepolarization | Increased, seizure | Jun 2, 2017 | Jun 2, 2017 |
|
3082 | Increased, epilepsy | Increase, Mortality | Oct 17, 2023 | Oct 17, 2023 |
|
3231 | Increase, ROS formation | Increase, Oxidative DNA damage | May 27, 2024 | May 27, 2024 | |
1595 | Increase, ROS formation | Increase, DNA Damage | Jun 29, 2017 | Jun 29, 2017 | |
1598 | Increase, ROS formation | Increase, LPO | Jun 29, 2017 | Jun 29, 2017 | |
1466 | Increase, ROS formation | Peptide Oxidation | Apr 15, 2017 | Apr 15, 2017 | |
2342 | Increase, ROS formation | D1 protein deactivation | Apr 11, 2021 | Apr 11, 2021 | |
2345 | Increase, ROS formation | Decrease, MMP | Apr 11, 2021 | Apr 11, 2021 | |
2826 | Increase, ROS formation | Oxidative Stress | Jan 9, 2023 | Jan 9, 2023 |
|
1469 | Increase, Apoptosis | Decrease, Oogenesis | Apr 15, 2017 | Apr 15, 2017 | |
1751 | Increase, Apoptosis | Increase, Mortality | Jun 12, 2018 | Jun 12, 2018 |
|
1741 | Increase, Apoptosis | Decrease, Growth | May 24, 2018 | May 24, 2018 | |
1596 | Increase, Apoptosis | Increase, Follicular atresia | Jun 29, 2017 | Jun 29, 2017 | |
3034 | Increase, Apoptosis | increased,Vascular endothelial dysfunction | Aug 28, 2023 | Aug 28, 2023 |
|
2948 | Increase, Apoptosis | Inhibition of neurotransmitter release | Jun 20, 2023 | Jun 20, 2023 | |
2075 | Increase, Apoptosis | Reduce, Sperm count | Apr 6, 2020 | Apr 6, 2020 |
|
2185 | Increase, Apoptosis | Increase, Tissue/organ damage | Nov 2, 2020 | Nov 2, 2020 | |
2461 | Increase, Apoptosis | Increased, Kidney Failure | Aug 5, 2021 | Aug 5, 2021 | |
2602 | Increase, Apoptosis | Microcephaly | Mar 17, 2022 | Mar 17, 2022 | |
2645 | Increase, Apoptosis | Occurrence, renal proximal tubular necrosis | Apr 8, 2022 | Apr 8, 2022 |
|
2619 | Increase, Apoptosis | Decreased spermatogenesis | Mar 28, 2022 | Mar 28, 2022 |
|
2725 | Increase, Apoptosis | Decrease, outgrowth | Jul 28, 2022 | Jul 28, 2022 | |
1470 | Decrease, Oogenesis | Decrease, Ovulation | Apr 15, 2017 | Apr 15, 2017 | |
1752 | Decrease, Oogenesis | Decrease, Fecundity | Jun 12, 2018 | Jun 12, 2018 |
|
2588 | Decrease, Oogenesis | Reduction, Cumulative fecundity and spawning | Mar 1, 2022 | Mar 1, 2022 |
|
2586 | Decrease, Oogenesis | Decrease, Reproduction | Mar 1, 2022 | Mar 1, 2022 | |
1480 | Activation, PTGS-1 | Increase, platelet aggregation | Apr 17, 2017 | Apr 17, 2017 |
|
1481 | Activation, PTGS-1 | Increase, mucosal blood flow | Apr 17, 2017 | Apr 17, 2017 |
|
1482 | Activation, PTGS-1 | Increase, mucous | Apr 17, 2017 | Apr 17, 2017 |
|
1483 | Activation, PTGS-1 | Increase, bicarbonate | Apr 17, 2017 | Apr 17, 2017 |
|
1478 | Activation, PTGS-2 | Decrease, leukocyte adherence | Apr 17, 2017 | Apr 17, 2017 |
|
1479 | Activation, PTGS-2 | Increase, angiogenesis | Apr 17, 2017 | Apr 17, 2017 |
|
1484 | Increase, bicarbonate | Activate, mucosal defense | Apr 17, 2017 | Apr 17, 2017 |
|
1485 | Increase, mucous | Activate, mucosal defense | Apr 17, 2017 | Apr 17, 2017 |
|
1486 | Increase, mucosal blood flow | Activate, mucosal defense | Apr 17, 2017 | Apr 17, 2017 |
|
1474 | Increase, platelet aggregation | Inhibit, gastric ulcer formation | Apr 17, 2017 | Apr 17, 2017 |
|
1473 | Increase, angiogenesis | Inhibit, gastric ulcer formation | Apr 17, 2017 | Apr 17, 2017 |
|
3308 | Increase, angiogenesis | Increase, Cancer | Jul 18, 2024 | Jul 18, 2024 | |
3137 | Increase, angiogenesis | Metastasis, Breast Cancer | Mar 5, 2024 | Mar 5, 2024 |
|
2578 | Increase, angiogenesis | N/A, Breast Cancer | Feb 15, 2022 | Feb 15, 2022 | |
1477 | Increase, leukocyte adherence | Activate, leukocyte | Apr 17, 2017 | Apr 17, 2017 |
|
1476 | Activate, leukocyte | Activated, gastric ulcer formation | Apr 17, 2017 | Apr 17, 2017 |
|
1475 | Activate, mucosal defense | Inhibit, gastric ulcer formation | Apr 17, 2017 | Apr 17, 2017 |
|
1489 | Increase, surfactant | Activate, mucosal defense | Apr 17, 2017 | Apr 17, 2017 |
|
1547 | Decrease, surfactant | Reduced, mucosal defense | Jun 2, 2017 | Jun 2, 2017 |
|
1488 | Activate, phospholipase | Decrease, surfactant | Apr 17, 2017 | Apr 17, 2017 |
|
1487 | Increase, ammonium (NH4+) | Decrease, surfactant | Apr 17, 2017 | Apr 17, 2017 |
|
1493 | CYP7B activity, inhibition | 7α-hydroxypregnenolone synthesis in the brain, decreased | May 2, 2017 | May 17, 2017 |
|
1494 | CYP7B activity, inhibition | Locomotor activity, decreased | May 2, 2017 | May 17, 2017 |
|
1495 | 7α-hydroxypregnenolone synthesis in the brain, decreased | Locomotor activity, decreased | May 2, 2017 | May 17, 2017 |
|
1496 | 7α-hydroxypregnenolone synthesis in the brain, decreased | Dopamine release in the brain, decreased | May 2, 2017 | May 25, 2017 |
|
1498 | 7α-hydroxypregnenolone synthesis in the brain, decreased | Sexual behavior, decreased | May 3, 2017 | May 17, 2017 |
|
1497 | Dopamine release in the brain, decreased | Locomotor activity, decreased | May 2, 2017 | May 2, 2017 |
|
1502 | Dopamine release in the brain, decreased | Sexual behavior, decreased | May 9, 2017 | May 9, 2017 |
|
1500 | Locomotor activity, decreased | Decreased, Reproductive Success | May 8, 2017 | Jun 26, 2017 |
|
1499 | Sexual behavior, decreased | Decreased, Reproductive Success | May 8, 2017 | May 8, 2017 |
|
1512 | Activation of Cyp2E1 | Oxidative Stress | May 30, 2017 | Jul 1, 2021 |
|
1515 | Activation of Cyp2E1 | Hepatocytotoxicity | May 30, 2017 | Dec 6, 2018 |
|
1513 | Oxidative Stress | Hepatocytotoxicity | May 30, 2017 | Jun 19, 2021 |
|
1516 | Oxidative Stress | Liver Cancer | May 30, 2017 | Jun 19, 2021 |
|
1685 | Oxidative Stress | Glutamate dyshomeostasis | Nov 9, 2017 | Feb 6, 2020 |
|
1690 | Oxidative Stress | Cell injury/death | Nov 9, 2017 | Feb 7, 2020 |
|
2505 | Oxidative Stress | p-Tau | Oct 26, 2021 | Oct 26, 2021 |
|
2716 | Oxidative Stress | Increase, Cell death | Jul 25, 2022 | Aug 23, 2024 |
|
2674 | Oxidative Stress | Pulmonary inflammation | Jun 17, 2022 | Jun 17, 2022 |
|
2714 | Oxidative Stress | Mitochondrial Injury | Jul 25, 2022 | Jul 25, 2022 |
|
2771 | Oxidative Stress | Altered Signaling | Sep 28, 2022 | Feb 13, 2024 | |
2772 | Oxidative Stress | Increased pro-inflammatory mediators | Sep 28, 2022 | Aug 26, 2024 |
|
2774 | Oxidative Stress | Altered, Nitric Oxide Levels | Sep 28, 2022 | Nov 26, 2024 |
|
2776 | Oxidative Stress | Increase, Endothelial Dysfunction | Sep 28, 2022 | Aug 27, 2024 |
|
2810 | Oxidative Stress | Increase, Oxidative DNA damage | Dec 16, 2022 | Mar 8, 2024 |
|
2811 | Oxidative Stress | Increase, DNA strand breaks | Dec 16, 2022 | Jul 29, 2024 |
|
2812 | Oxidative Stress | Modified Proteins | Dec 16, 2022 | Mar 30, 2023 |
|
2827 | Oxidative Stress | Mitochondrial dysfunction EMPTY | Jan 9, 2023 | Jan 9, 2023 | |
2818 | Oxidative Stress | Cataracts | Dec 18, 2022 | Mar 11, 2024 |
|
2833 | Oxidative Stress | Tissue resident cell activation | Jan 25, 2023 | Jul 26, 2024 |
|
2846 | Oxidative Stress | Altered Bone Cell Homeostasis | Jan 25, 2023 | Aug 12, 2024 |
|
3239 | Oxidative Stress | Increase, Oocyte apoptosis | May 31, 2024 | May 31, 2024 |
|
3316 | Oxidative Stress | Altered Stress Response Signaling | Jul 24, 2024 | Aug 26, 2024 |
|
3319 | Oxidative Stress | Altered cell differentiation signaling | Jul 24, 2024 | Aug 23, 2024 |
|
3129 | Oxidative Stress | Mitochondrial dysfunction | Feb 17, 2024 | May 31, 2024 |
|
3116 | Oxidative Stress | Increase, LPO | Jan 24, 2024 | Apr 11, 2024 |
|
2975 | Oxidative Stress | Increase, Inflammation | Jul 31, 2023 | Oct 19, 2023 |
|
3047 | Oxidative Stress | Accumulation, misfolded proteins | Sep 14, 2023 | Sep 14, 2023 |
|
3048 | Oxidative Stress | Proteasomal dysfunction | Sep 14, 2023 | Sep 14, 2023 |
|
3322 | Oxidative Stress | Decreased, Neuronal network function in adult brain | Jul 24, 2024 | Jul 24, 2024 |
|
3382 | Oxidative Stress | Increase mutations | Nov 6, 2024 | Nov 6, 2024 |
|
3324 | Oxidative Stress | Down Regulation, Gulcose-6-phosphate dehydrogenase | Jul 24, 2024 | Jul 24, 2024 |
|
3325 | Oxidative Stress | Damaging, Red blood cells; hemolysis | Jul 24, 2024 | Jul 24, 2024 |
|
3283 | Oxidative Stress | Activated Wnt/Frizzled pathway | Jul 4, 2024 | Jul 4, 2024 |
|
3314 | Oxidative Stress | Neuronal network function, Decreased | Jul 23, 2024 | Jul 23, 2024 |
|
3277 | Oxidative Stress | Activation, inflammation pathway | Jul 4, 2024 | Jul 4, 2024 |
|
3279 | Oxidative Stress | Abnormal expression of NO | Jul 4, 2024 | Jul 4, 2024 |
|
3280 | Oxidative Stress | Activated ANG/Tie2 pathway | Jul 4, 2024 | Jul 4, 2024 |
|
3281 | Oxidative Stress | Activation, Dll4-Notch pathway | Jul 4, 2024 | Jul 4, 2024 |
|
3282 | Oxidative Stress | Activated BMP/TGF-beta pathway | Jul 4, 2024 | Jul 4, 2024 |
|
3312 | Oxidative Stress | N/A, Neurodegeneration | Jul 23, 2024 | Jul 23, 2024 |
|
3284 | Oxidative Stress | Uncoupling, eNOS | Jul 4, 2024 | Jul 4, 2024 |
|
3285 | Oxidative Stress | Activated AKT/ERK/PI3K pathway | Jul 4, 2024 | Jul 4, 2024 |
|
3286 | Oxidative Stress | Inhibition VEGF/VEGFR pathway | Jul 4, 2024 | Jul 4, 2024 |
|
3294 | Oxidative Stress | Ferroptosis related pathways activation | Jul 9, 2024 | Jul 9, 2024 |
|
3293 | Oxidative Stress | The NO synthase pathway activation | Jul 9, 2024 | Jul 9, 2024 |
|
3274 | Oxidative Stress | TH synthesis, Decreased | Jul 4, 2024 | Jul 4, 2024 |
|
3272 | Oxidative Stress | Impaired insulin signaling | Jul 4, 2024 | Jul 4, 2024 |
|
3270 | Oxidative Stress | Increase, Apoptosis | Jul 4, 2024 | Jul 4, 2024 |
|
3310 | Oxidative Stress | Lipid Peroxidation | Jul 23, 2024 | Jul 23, 2024 |
|
3267 | Oxidative Stress | Increase, DNA Damage | Jul 4, 2024 | Jul 4, 2024 |
|
3252 | Oxidative Stress | Neuroinflammation | Jun 19, 2024 | Jun 19, 2024 |
|
3264 | Oxidative Stress | Occurrence, renal proximal tubular necrosis | Jul 3, 2024 | Jul 3, 2024 |
|
3311 | Oxidative Stress | Unfolded Protein Response | Jul 23, 2024 | Jul 23, 2024 |
|
3262 | Oxidative Stress | Increased, secretion of local growth factors | Jul 3, 2024 | Jul 3, 2024 |
|
3249 | Oxidative Stress | Apoptosis | Jun 19, 2024 | Jun 19, 2024 |
|
3442 | Oxidative Stress | Increased, LDL uptake | Nov 25, 2024 | Nov 25, 2024 |
|
2008 | Oxidative Stress | Wnt ligand stimulation | Dec 3, 2019 | Dec 3, 2019 | |
2451 | Oxidative Stress | CBF, Decreased | Aug 2, 2021 | Mar 24, 2023 |
|
2450 | Oxidative Stress | FOXJ1 Protein, Decreased | Aug 2, 2021 | Sep 28, 2021 |
|
2449 | Oxidative Stress | CFTR Function, Decreased | Jul 30, 2021 | Sep 28, 2021 |
|
2289 | Oxidative Stress | Coagulation | Mar 25, 2021 | Mar 25, 2021 | |
1514 | Hepatocytotoxicity | Sustained proliferation | May 30, 2017 | Jun 19, 2021 |
|
1517 | Hepatocytotoxicity | Liver Cancer | May 30, 2017 | May 1, 2020 |
|
1518 | Sustained proliferation | Liver Cancer | May 30, 2017 | Oct 9, 2020 |
|
1522 | Increased, glucocorticoid receptor activity | Reduced, BDNF | May 31, 2017 | May 31, 2017 |
|
1524 | Increased, serotonin transporter activity | Increased, intracellular serotonin | Jun 1, 2017 | Jun 1, 2017 |
|
1528 | Increased, serotonin transporter activity | Decreased, extracellular serotonin | Jun 1, 2017 | Jun 1, 2017 |
|
1525 | Increased, intracellular serotonin | Increased, packaged serotonin | Jun 1, 2017 | Jun 1, 2017 |
|
1526 | Increased, packaged serotonin | Increased, synaptic release | Jun 1, 2017 | Jun 1, 2017 |
|
1527 | Increased, synaptic release | Increased, extracellular serotonin | Jun 1, 2017 | Jun 1, 2017 |
|
1530 | Decreased, 5-HT3 | Increased, seizure | Jun 1, 2017 | Jun 1, 2017 |
|
1532 | Reduced, PTGS1 function | Reduced, platelet aggregation | Jun 2, 2017 | Jun 2, 2017 |
|
1534 | Reduced, PTGS1 function | Decreased, mucosal blood flow | Jun 2, 2017 | Jun 2, 2017 |
|
1537 | Reduced, PTGS1 function | Decreased, mucous | Jun 2, 2017 | Jun 2, 2017 |
|
1539 | Reduced, PTGS1 function | Decreased, bicarbonate | Jun 2, 2017 | Jun 2, 2017 |
|
1533 | Reduced, platelet aggregation | Activated, gastric ulcer formation | Jun 2, 2017 | Jun 2, 2017 |
|
1535 | Decreased, mucosal blood flow | Reduced, mucosal defense | Jun 2, 2017 | Jun 2, 2017 |
|
1536 | Reduced, mucosal defense | Activated, gastric ulcer formation | Jun 2, 2017 | Jun 2, 2017 |
|
1548 | Reduced, mucosal defense | Helicobacter pylori infection | Jun 2, 2017 | Jun 2, 2017 | |
1538 | Decreased, mucous | Reduced, mucosal defense | Jun 2, 2017 | Jun 2, 2017 |
|
1540 | Decreased, bicarbonate | Reduced, mucosal defense | Jun 2, 2017 | Jun 2, 2017 |
|
1541 | Reduced, PTGS2 function | Decreased, angiogenesis | Jun 2, 2017 | Jun 2, 2017 |
|
1543 | Reduced, PTGS2 function | Increased, leukocyte adherence | Jun 2, 2017 | Jun 2, 2017 |
|
1542 | Decreased, angiogenesis | Activated, gastric ulcer formation | Jun 2, 2017 | Jun 2, 2017 |
|
1544 | Increased, leukocyte adherence | Increased, leukocyte activation | Jun 2, 2017 | Jun 2, 2017 |
|
1545 | Increased, leukocyte activation | Activated, gastric ulcer formation | Jun 2, 2017 | Jun 2, 2017 |
|
1546 | Helicobacter pylori infection | Increase, ammonium (NH4+) | Jun 2, 2017 | Jun 2, 2017 |
|
1551 | Reduced, presynaptic neuron 2 activity | Decreased, GABA | Jun 2, 2017 | Jun 2, 2017 |
|
1552 | Decreased, GABA | Reduced, GABA-A receptor activation | Jun 2, 2017 | Jun 2, 2017 |
|
1553 | Reduced, GABA-A receptor activation | Decreased, intracellular chloride | Jun 2, 2017 | Jun 2, 2017 |
|
1554 | Decreased, intracellular chloride | Activated, membrane depolarization | Jun 2, 2017 | Jun 2, 2017 |
|
1556 | NFE2/Nrf2 repression | Reduced, FXR activity | Jun 2, 2017 | Jun 2, 2017 |
|
2979 | NFE2/Nrf2 repression | Increase, Oxidative Stress | Aug 19, 2023 | Aug 19, 2023 | |
2984 | NFE2/Nrf2 repression | Activation, HIF1α | Aug 20, 2023 | Aug 20, 2023 |
|
3035 | NFE2/Nrf2 repression | Activation, inflammation pathway | Aug 28, 2023 | Aug 28, 2023 |
|
3276 | NFE2/Nrf2 repression | Oxidative Stress | Jul 4, 2024 | Jul 4, 2024 |
|
1557 | Reduced, FXR activity | Reduced, SHP activity | Jun 2, 2017 | Jun 2, 2017 |
|
1558 | Reduced, SHP activity | Activated, LXR | Jun 2, 2017 | Jun 2, 2017 |
|
1559 | Activated, LXR | Reduced, PPARalpha | Jun 2, 2017 | Jun 2, 2017 |
|
1560 | Reduced, PPARalpha | Reduced, HSD17B4 activity | Jun 2, 2017 | Jun 2, 2017 |
|
1561 | Reduced, HSD17B4 activity | Reduced, fatty acid beta oxidation | Jun 2, 2017 | Jun 2, 2017 |
|
3215 | Reduced, fatty acid beta oxidation | Increased, Liver Steatosis | May 9, 2024 | May 9, 2024 |
|
1563 | Mu Opioid Receptor Agonism | Release of G Proteins | Jun 8, 2017 | Jun 8, 2017 |
|
1564 | Release of G Proteins | Opening of GIRK channels | Jun 8, 2017 | Jun 8, 2017 |
|
1568 | Release of G Proteins | Inhibition of Ca Channels | Jun 23, 2017 | Jun 23, 2017 |
|
1565 | Opening of GIRK channels | hyperpolarisation, neuron | Jun 8, 2017 | Jun 8, 2017 |
|
1569 | Inhibition of Ca Channels | Inhibition of neurotransmitter release | Jun 23, 2017 | Jun 23, 2017 |
|
1570 | Inhibition of neurotransmitter release | Analgesia | Jun 23, 2017 | Jun 23, 2017 |
|
1573 | Inhibition of neurotransmitter release | Anti-depressant Activity | Jun 23, 2017 | Jun 23, 2017 |
|
1571 | Serotonin 1A Receptor Agonism | Release of G Proteins | Jun 23, 2017 | Jun 23, 2017 |
|
1579 | Increased CGRP | Increased Airway Hyper-responsiveness,Cough, Dyspnea | Jun 23, 2017 | Jun 23, 2017 | |
1580 | Increased CGRP | Increase, hypertension | Jun 23, 2017 | Jun 23, 2017 | |
1586 | Increased CGRP | Leukocyte infiltration | Jun 23, 2017 | Jun 23, 2017 | |
1587 | Increased CGRP | Respiratory irritability | Jun 27, 2017 | Jun 27, 2017 |
|
1774 | Irritation induced sneezing | Increased Airway Hyper-responsiveness,Cough, Dyspnea | Sep 24, 2018 | Sep 24, 2018 | |
1773 | Increased NKA | Respiratory irritability | Sep 24, 2018 | Sep 24, 2018 |
|
1584 | Increased NKA | Increased Airway Hyper-responsiveness,Cough, Dyspnea | Jun 23, 2017 | Jun 23, 2017 | |
1585 | Increased NKA | Leukocyte infiltration | Jun 23, 2017 | Jun 23, 2017 | |
1588 | Sensing of the stressor | Increased transcription of genes encoding acute phase proteins | Jun 29, 2017 | Jun 29, 2017 | |
1589 | Increased transcription of genes encoding acute phase proteins | Systemic acute phase response | Jun 29, 2017 | Dec 19, 2023 |
|
1590 | Systemic acute phase response | HDL-SAA formation | Jun 29, 2017 | Jun 29, 2017 | |
2860 | Systemic acute phase response | Atherosclerosis | Mar 28, 2023 | Dec 18, 2023 |
|
1591 | HDL-SAA formation | Systemic cholesterol increased | Jun 29, 2017 | Jun 29, 2017 | |
1593 | HDL-SAA formation | Foam cell formation | Jun 29, 2017 | Jun 29, 2017 | |
1592 | Systemic cholesterol increased | Foam cell formation | Jun 29, 2017 | Jun 29, 2017 | |
1594 | Foam cell formation | Atherosclerosis | Jun 29, 2017 | Jun 29, 2017 | |
1597 | Increase, Follicular atresia | Decrease, Oogenesis | Jun 29, 2017 | Jun 29, 2017 |
|
2211 | Increase, Follicular atresia | Decrease, Fecundity | Nov 25, 2020 | Nov 25, 2020 | |
2210 | Increase, LPO | Increase, Apoptosis | Nov 25, 2020 | Nov 25, 2020 | |
2222 | Increase, LPO | Increase, Cell death | Dec 4, 2020 | Dec 4, 2020 | |
2464 | Increase, LPO | Increase, Necrosis | Aug 11, 2021 | Aug 11, 2021 |
|
1599 | Increase, LPO | Decrease, Coupling of OXPHOS | Jun 29, 2017 | Jun 29, 2017 | |
2879 | Increase, LPO | impaired, Fertility | Apr 5, 2023 | Sep 14, 2023 |
|
3117 | Increase, LPO | Increased, histomorphological alteration of testis | Jan 24, 2024 | Apr 11, 2024 |
|
3364 | Increase, LPO | Cell cycle, disrupted | Oct 8, 2024 | Oct 8, 2024 |
|
3360 | Increase, LPO | Cell injury/death | Oct 8, 2024 | Oct 8, 2024 |
|
2097 | Increase, LPO | Decrease, TAG | Apr 30, 2020 | Apr 30, 2020 |
|
2175 | Decrease, Coupling of OXPHOS | Decrease, ATP synthase activity | Nov 2, 2020 | Nov 2, 2020 | |
2182 | Decrease, Coupling of OXPHOS | Increase, Complex III dysfunction | Nov 2, 2020 | Nov 2, 2020 | |
2188 | Decrease, Coupling of OXPHOS | Increase, Complex I dysfunction | Nov 2, 2020 | Nov 2, 2020 | |
2203 | Decrease, Coupling of OXPHOS | Decrease, ATP pool | Nov 12, 2020 | Jul 6, 2022 |
|
2219 | Decrease, Coupling of OXPHOS | Increase, Oxygen consumption | Dec 4, 2020 | Dec 4, 2020 | |
2763 | Decrease, Coupling of OXPHOS | Increase, Cytosolic Ca | Sep 13, 2022 | Sep 13, 2022 |
|
2796 | Decrease, Coupling of OXPHOS | Increase, Mitochondrial swelling | Nov 1, 2022 | Nov 1, 2022 |
|
2793 | Decrease, Coupling of OXPHOS | Increase, Glycolysis | Nov 1, 2022 | Nov 1, 2022 |
|
3234 | Decrease, Coupling of OXPHOS | Increase, ROS | May 28, 2024 | May 28, 2024 |
|
1600 | Decrease, Coupling of OXPHOS | Decrease, Mitochondrial ATP production | Jun 29, 2017 | Jun 29, 2017 | |
1610 | activation of CEBPA | Activation of specific nuclear receptors, PPAR-gamma activation | Jul 24, 2017 | Jul 24, 2017 |
|
1611 | activation of CEBPA | increased adipogenesis | Jul 24, 2017 | Jul 24, 2017 |
|
1612 | increased adipogenesis | obesity | Jul 24, 2017 | Jul 24, 2017 |
|
1614 | decreased dopamine | decreased reward | Jul 24, 2017 | Jul 24, 2017 |
|
1615 | decreased reward | decreased DNA methylation of tyrosine hydroxylase | Jul 24, 2017 | Jul 24, 2017 |
|
1616 | decreased reward | decreased methylation of dopamine transporter promoter | Jul 24, 2017 | Jul 24, 2017 |
|
1617 | decreased reward | decreased dopamine | Jul 24, 2017 | Jul 24, 2017 |
|
1618 | decreased DNA methylation of tyrosine hydroxylase | obesity | Jul 24, 2017 | Jul 24, 2017 |
|
1620 | decreased DNA methylation of tyrosine hydroxylase | decreased dopamine | Jul 24, 2017 | Jul 24, 2017 |
|
1619 | decreased methylation of dopamine transporter promoter | obesity | Jul 24, 2017 | Jul 24, 2017 |
|
1621 | decreased methylation of dopamine transporter promoter | decreased dopamine | Jul 24, 2017 | Jul 24, 2017 |
|
1613 | chronic high fat diet | decreased dopamine | Jul 24, 2017 | Jul 24, 2017 |
|
1622 | Sustained inflammatory cytokine release | Increased, secretion of local growth factors | Jul 26, 2017 | Jul 26, 2017 | |
1633 | Sustained inflammatory cytokine release | Differentiation of fibroblasts | Jul 26, 2017 | Jul 26, 2017 | |
1626 | Differentiation of fibroblasts | Expression of Collagen | Jul 26, 2017 | Jul 26, 2017 | |
1654 | Differentiation of fibroblasts | Accumulation, Collagen | Aug 16, 2017 | Aug 16, 2017 |
|
1627 | EMT | Expression of Collagen | Jul 26, 2017 | Jul 26, 2017 | |
1655 | EMT | Accumulation, Collagen | Aug 16, 2017 | Aug 16, 2017 |
|
1725 | EMT | Lung fibrosis | Mar 18, 2018 | Mar 18, 2018 | |
2154 | EMT | Pulmonary fibrosis | Jul 9, 2020 | Jul 9, 2020 |
|
2614 | EMT | Metastasis, Breast Cancer | Mar 22, 2022 | Sep 26, 2023 |
|
1779 | EMT | Collagen Deposition | Nov 20, 2018 | Nov 20, 2018 |
|
1840 | EMT | Fibroproliferative airway lesions | Jan 30, 2019 | Jan 30, 2019 |
|
3200 | EMT | Resistant gastric cancer | Apr 23, 2024 | Apr 23, 2024 |
|
3204 | EMT | Airway remodeling | May 1, 2024 | May 1, 2024 |
|
3306 | EMT | Increase, Cancer | Jul 18, 2024 | Jul 18, 2024 |
|
1630 | Cell damage sensing | Sustained inflammatory cytokine release | Jul 26, 2017 | Jul 26, 2017 | |
1631 | Cell damage sensing | Increase, ROS | Jul 26, 2017 | Jul 26, 2017 | |
1632 | Cell damage sensing | Increased, secretion of local growth factors | Jul 26, 2017 | Jul 26, 2017 | |
1635 | Increase, DSB | MLL translocation | Aug 2, 2017 | Aug 1, 2022 |
|
3096 | Increase, DSB | Increase, Apoptosis | Nov 16, 2023 | Nov 16, 2023 |
|
3099 | Increase, DSB | Increase, Casp transcription | Nov 16, 2023 | Nov 16, 2023 |
|
1636 | Thiol protein adducts | Inhibition of lysyl oxidase | Aug 3, 2017 | Aug 3, 2017 |
|
1637 | Inhibition of lysyl oxidase | Reduction of collagen crosslinking | Aug 3, 2017 | Aug 3, 2017 |
|
1638 | Reduction of collagen crosslinking | Weak collagen matrix | Aug 3, 2017 | Aug 3, 2017 |
|
1639 | Weak collagen matrix | Notochord malformation | Aug 3, 2017 | Aug 3, 2017 |
|
1640 | Notochord malformation | Reduced, Swimming performance | Aug 3, 2017 | Aug 3, 2017 |
|
1651 | TGFbeta1 activation | TGFbeta pathway activation | Aug 16, 2017 | Aug 16, 2017 |
|
1652 | TGFbeta pathway activation | Differentiation of fibroblasts | Aug 16, 2017 | Aug 16, 2017 |
|
1653 | TGFbeta pathway activation | EMT | Aug 16, 2017 | Aug 16, 2017 |
|
1663 | Increase, Uncoupling of photophosphorylation | Decrease, ATP production | Oct 10, 2017 | Oct 10, 2017 |
|
1664 | Decrease, ATP production | Decrease, Chlorophyll synthesis | Oct 10, 2017 | Oct 10, 2017 |
|
2547 | Decrease, ATP production | Decrease, Reproduction | Jan 21, 2022 | Jan 21, 2022 |
|
2341 | Decrease, ATP production | Decrease, Leaf development | Apr 11, 2021 | Apr 11, 2021 |
|
1665 | Decrease, Chlorophyll synthesis | Decrease, Light harvest capacity | Oct 10, 2017 | Oct 10, 2017 |
|
1666 | Decrease, Light harvest capacity | Decrease, Photosynthesis | Oct 10, 2017 | Oct 10, 2017 |
|
1667 | Decrease, Photosynthesis | Decrease, Glycolysis | Oct 10, 2017 | Oct 10, 2017 |
|
2334 | Decrease, Photosynthesis | Decrease, ATP production | Apr 11, 2021 | Apr 11, 2021 |
|
2343 | Decrease, Photosynthesis | Decrease, ATP synthase activity | Apr 11, 2021 | Apr 11, 2021 | |
1668 | Decrease, Glycolysis | Decrease, OXPHOS | Oct 10, 2017 | Oct 10, 2017 |
|
1738 | Decrease, Glycolysis | Decrease, Mitochondrial ATP production | May 24, 2018 | May 24, 2018 | |
1669 | Decrease, OXPHOS | Decrease, Mitochondrial ATP production | Oct 10, 2017 | Oct 10, 2017 |
|
2346 | Decrease, OXPHOS | Decrease, ATP synthase activity | Apr 11, 2021 | Apr 11, 2021 | |
2095 | Decrease, OXPHOS | Decrease, ATP pool | Apr 30, 2020 | Apr 30, 2020 |
|
1810 | Decrease, OXPHOS | Decreased Na/K ATPase activity | Dec 20, 2018 | Dec 20, 2018 |
|
2713 | Decrease, OXPHOS | Oxidative Stress | Jul 25, 2022 | Jul 25, 2022 | |
1671 | Decrease, Leaf cell mitosis | Decrease, Leaf development | Oct 10, 2017 | Oct 10, 2017 |
|
1672 | Decrease, Leaf development | Increase, Growth hormone | Oct 10, 2017 | Oct 10, 2017 | |
2335 | Decrease, Leaf development | Decrease, Reproduction | Apr 11, 2021 | Apr 11, 2021 |
|
2283 | Decrease, Leaf development | Decrease, Growth | Feb 16, 2021 | Feb 16, 2021 |
|
1673 | Inhibition, mitochondrial DNA polymerase gamma (Pol gamma) | Depletion, mtDNA | Oct 25, 2017 | Oct 25, 2017 |
|
3133 | Depletion, mtDNA | Mitochondrial dysfunction | Feb 28, 2024 | Feb 28, 2024 |
|
1677 | Binding of substrate, endocytic receptor | Disturbance, Lysosomal function | Oct 25, 2017 | Oct 25, 2017 |
|
1683 | Binding, SH/SeH proteins involved in protection against oxidative stress | Mitochondrial dysfunction | Nov 9, 2017 | Nov 9, 2017 | |
1689 | Binding, SH/SeH proteins involved in protection against oxidative stress | Oxidative Stress | Nov 9, 2017 | Feb 7, 2018 | |
1765 | Binding, SH/SeH proteins involved in protection against oxidative stress | Protection against oxidative stress, decreased | Sep 13, 2018 | Feb 10, 2020 |
|
1686 | Glutamate dyshomeostasis | Cell injury/death | Nov 9, 2017 | Feb 6, 2020 |
|
1691 | Glutamate dyshomeostasis | Neuronal network function, Decreased | Nov 9, 2017 | Nov 9, 2017 | |
1692 | Inhibition of fatty acid beta oxidation | Increase, cytosolic fatty acid | Nov 13, 2017 | Nov 13, 2017 |
|
1697 | increased, oncotic necrosis | steatohepatitis | Nov 14, 2017 | Nov 14, 2017 |
|
1763 | Tissue resident cell activation | Increased pro-inflammatory mediators | Aug 2, 2018 | Aug 2, 2018 |
|
2834 | Tissue resident cell activation | Increase, Pro-Inflammatory Mediators | Jan 25, 2023 | Jul 26, 2024 |
|
2777 | Increased pro-inflammatory mediators | Increase, Endothelial Dysfunction | Sep 28, 2022 | Aug 26, 2024 |
|
1764 | Increased pro-inflammatory mediators | Activation, Stellate cells | Aug 2, 2018 | Aug 2, 2018 |
|
1719 | Increased pro-inflammatory mediators | Cell injury/death | Feb 1, 2018 | Feb 12, 2018 |
|
1777 | Increased pro-inflammatory mediators | Leukocyte recruitment/activation | Nov 12, 2018 | Nov 12, 2018 |
|
1903 | Increased pro-inflammatory mediators | Increase in RONS | May 7, 2019 | May 9, 2019 |
|
1902 | Increased pro-inflammatory mediators | N/A, Breast Cancer | May 7, 2019 | May 10, 2019 |
|
1908 | Increased pro-inflammatory mediators | Increase, Cell Proliferation (Epithelial Cells) | May 10, 2019 | May 10, 2019 |
|
1905 | Leukocyte recruitment/activation | Increase in RONS | May 7, 2019 | May 9, 2019 |
|
1778 | Leukocyte recruitment/activation | Activation, Stellate cells | Nov 12, 2018 | Nov 12, 2018 |
|
1901 | Leukocyte recruitment/activation | Increase, Cell Proliferation (Epithelial Cells) | May 7, 2019 | May 7, 2019 | |
2891 | Leukocyte recruitment/activation | Increased extracellular matrix deposition | Apr 13, 2023 | Apr 13, 2023 | |
2958 | Interaction with the lung cell membrane | Increased transcription of genes encoding acute phase proteins | Jul 4, 2023 | Dec 19, 2023 |
|
2959 | Interaction with the lung cell membrane | Systemic acute phase response | Jul 4, 2023 | Dec 19, 2023 |
|
2960 | Interaction with the lung cell membrane | Atherosclerosis | Jul 4, 2023 | Dec 18, 2023 |
|
1702 | Interaction with the lung cell membrane | Increased proinflammatory mediators | Jan 5, 2018 | Aug 29, 2023 |
|
2662 | Interaction with the lung cell membrane | Increased, Reactive oxygen species | May 25, 2022 | May 25, 2022 |
|
2663 | Interaction with the lung cell membrane | Increased, DNA damage and mutation | May 25, 2022 | May 25, 2022 |
|
2651 | Increased proinflammatory mediators | Activation, Dendritic Cells | Apr 28, 2022 | Aug 1, 2022 |
|
2301 | Increased proinflammatory mediators | Impaired gustatory nerve | Mar 28, 2021 | Mar 28, 2021 | |
2307 | Increased proinflammatory mediators | Accumulation, Collagen | Mar 30, 2021 | Mar 30, 2021 |
|
1703 | Increased proinflammatory mediators | Recruitment of inflammatory cells | Jan 5, 2018 | May 18, 2023 |
|
3052 | Increased proinflammatory mediators | Systemic acute phase response | Sep 19, 2023 | Dec 19, 2023 |
|
2061 | Increased proinflammatory mediators | Increased inflammatory immune responses | Mar 10, 2020 | Mar 10, 2020 |
|
2053 | Increased proinflammatory mediators | Increased transcription of genes encoding acute phase proteins | Mar 1, 2020 | Dec 19, 2023 |
|
2658 | Recruitment of inflammatory cells | Increase, Cytotoxicity (epithelial cells) | May 25, 2022 | May 25, 2022 |
|
2761 | Recruitment of inflammatory cells | Increased proinflammatory mediators | Sep 1, 2022 | Sep 1, 2022 |
|
1964 | Recruitment of inflammatory cells | Increased, Reactive oxygen species | Jul 3, 2019 | Jul 3, 2019 |
|
2543 | Recruitment of inflammatory cells | Gut dysbiosis | Dec 15, 2021 | Dec 15, 2021 | |
2492 | Recruitment of inflammatory cells | GI disorders | Oct 19, 2021 | Oct 19, 2021 | |
2491 | Recruitment of inflammatory cells | Disruption of the intestinal barrier | Oct 19, 2021 | Oct 19, 2021 | |
2903 | Recruitment of inflammatory cells | Increase in inflammation | May 4, 2023 | May 4, 2023 |
|
2354 | Recruitment of inflammatory cells | Hyperinflammation | Apr 20, 2021 | Feb 8, 2023 |
|
1704 | Recruitment of inflammatory cells | Loss of alveolar capillary membrane integrity | Jan 5, 2018 | May 18, 2023 |
|
1705 | Loss of alveolar capillary membrane integrity | Activation of Th2 cells | Jan 5, 2018 | May 16, 2023 |
|
2368 | Loss of alveolar capillary membrane integrity | Inhibition of LS function. | Apr 27, 2021 | Apr 27, 2021 |
|
2369 | Loss of alveolar capillary membrane integrity | Reduced tidal volume | Apr 27, 2021 | Apr 27, 2021 |
|
2372 | Loss of alveolar capillary membrane integrity | Decreased lung function | Apr 27, 2021 | Apr 27, 2021 |
|
2174 | Loss of alveolar capillary membrane integrity | Blood extravasation into the lungs | Oct 22, 2020 | Oct 22, 2020 | |
2258 | Loss of alveolar capillary membrane integrity | Impaired lung function | Jan 8, 2021 | Jan 8, 2021 | |
2259 | Loss of alveolar capillary membrane integrity | Substance - LS interaction | Jan 8, 2021 | Jan 8, 2021 | |
1706 | Activation of Th2 cells | Increased cellular proliferation and differentiation | Jan 5, 2018 | May 18, 2023 |
|
1707 | Increased cellular proliferation and differentiation | Increased extracellular matrix deposition | Jan 5, 2018 | Dec 7, 2021 | |
2652 | Increased cellular proliferation and differentiation | Accumulation, Collagen | May 4, 2022 | May 18, 2023 |
|
1708 | Increased extracellular matrix deposition | Pulmonary fibrosis | Jan 16, 2018 | Dec 6, 2021 | |
2325 | Increased extracellular matrix deposition | N/A, Liver fibrosis | Apr 10, 2021 | Apr 10, 2021 |
|
2699 | Histone deacetylase inhibition | Neural tube defects | Jul 19, 2022 | Jul 19, 2022 |
|
2010 | Histone deacetylase inhibition | Spermatocyte depletion | Dec 11, 2019 | Jul 1, 2021 |
|
1805 | Histone deacetylase inhibition | Reduced collagen production | Dec 20, 2018 | Dec 20, 2018 |
|
1802 | Histone deacetylase inhibition | Reduced neural crest cell migration | Dec 20, 2018 | Dec 20, 2018 |
|
1709 | Histone deacetylase inhibition | Histone acetylation, increase | Jan 21, 2018 | Aug 5, 2021 |
|
1714 | Histone deacetylase inhibition | p21 (CDKN1A) expression, increase | Jan 21, 2018 | Jul 25, 2018 | |
1715 | Histone deacetylase inhibition | Cell cycle, disrupted | Jan 21, 2018 | Jul 28, 2021 |
|
1716 | Histone deacetylase inhibition | Apoptosis | Jan 21, 2018 | Jul 1, 2021 |
|
1717 | Histone deacetylase inhibition | Testicular atrophy | Jan 21, 2018 | Jul 28, 2021 |
|
1710 | Histone acetylation, increase | p21 (CDKN1A) expression, increase | Jan 21, 2018 | Jul 25, 2018 | |
1997 | Histone acetylation, increase | Cell cycle, disrupted | Nov 11, 2019 | Jul 1, 2021 |
|
1806 | Histone acetylation, increase | Altered, Gene Expression | Dec 20, 2018 | Dec 20, 2018 |
|
1711 | p21 (CDKN1A) expression, increase | Cell cycle, disrupted | Jan 21, 2018 | Jul 25, 2018 | |
1712 | Cell cycle, disrupted | Apoptosis | Jan 21, 2018 | Jul 28, 2021 |
|
2791 | Cell cycle, disrupted | Altered, Meiotic chromosome dynamics | Oct 25, 2022 | Oct 25, 2022 |
|
3363 | Cell cycle, disrupted | Decrease, Cell proliferation | Oct 8, 2024 | Oct 8, 2024 |
|
1720 | Activation of PPARγ | Increase, Inflammation | Mar 18, 2018 | Mar 18, 2018 | |
3309 | CYP2E1 Activation | Oxidative Stress | Jul 23, 2024 | Jul 23, 2024 |
|
1729 | Protein Adduct Formation | Unfolded Protein Response | Apr 4, 2018 | Apr 5, 2018 |
|
1731 | Lipid Peroxidation | General Apoptosis | Apr 4, 2018 | Apr 5, 2018 |
|
1728 | Lipid Peroxidation | Protein Adduct Formation | Apr 4, 2018 | Apr 5, 2018 |
|
3377 | Lipid Peroxidation | Foam cell formation | Oct 30, 2024 | Oct 30, 2024 | |
3041 | Unfolded Protein Response | Caspase activation | Sep 14, 2023 | Sep 14, 2023 |
|
1732 | Unfolded Protein Response | General Apoptosis | Apr 4, 2018 | Apr 5, 2018 |
|
1866 | Unfolded Protein Response | Apoptosis | Mar 6, 2019 | Mar 6, 2019 |
|
2712 | Unfolded Protein Response | Increase, Cell death | Jul 25, 2022 | Jul 25, 2022 | |
1733 | General Apoptosis | Neurodegeneration | Apr 4, 2018 | Apr 5, 2018 |
|
2977 | General Apoptosis | Increase, Cancer | Jul 31, 2023 | Oct 19, 2023 |
|
1734 | Spermatocyte depletion | Testicular atrophy | May 22, 2018 | Jul 28, 2021 |
|
1736 | Increase, D1 protein antagonism | Decrease, PSII activity | May 24, 2018 | May 24, 2018 | |
1740 | Decrease, PSII activity | Increase, ROS formation | May 24, 2018 | May 24, 2018 | |
1737 | Decrease, PSII activity | Decrease, Photosynthesis | May 24, 2018 | May 24, 2018 | |
2169 | Decrease, Growth | Decrease, Population growth rate | Oct 8, 2020 | Oct 8, 2020 | |
2804 | Decrease, Growth | Decreased, Reproductive Success | Nov 16, 2022 | Nov 16, 2022 |
|
1742 | Inhibition, CHS-1 | Decrease, Cuticular chitin content | May 24, 2018 | Feb 17, 2021 |
|
1743 | Decrease, Cuticular chitin content | Increase, Premature molting | May 24, 2018 | Feb 17, 2021 |
|
1744 | Increase, Premature molting | Increase, Mortality | May 24, 2018 | Feb 17, 2021 |
|
1745 | Increase, SUR binding | Increase, Cell membrane depolarization | May 24, 2018 | May 24, 2018 |
|
1747 | Increase, Opening of voltage-dependent calcium channel | Decrease, Cuticular chitin content | May 24, 2018 | May 24, 2018 |
|
1746 | Increase, Cell membrane depolarization | Increase, Opening of voltage-dependent calcium channel | May 24, 2018 | May 24, 2018 |
|
2788 | Increase, Cell membrane depolarization | Cell injury/death | Oct 19, 2022 | Oct 19, 2022 |
|
2708 | Increase, Cell membrane depolarization | Increased, Intracellular Calcium overload | Jul 25, 2022 | Jul 25, 2022 | |
3039 | Increase, Cell membrane depolarization | Opening VGCCs | Sep 14, 2023 | Sep 14, 2023 |
|
1749 | Fatty Acid Beta Oxidation, Decreased | Decreased, Ketogenesis (production of ketone bodies) | Jun 11, 2018 | Jun 11, 2018 |
|
1755 | Blockade, L-Type Calcium Channels | Decrease, Calcium currents | Jun 19, 2018 | Jun 19, 2018 |
|
3406 | Blockade, L-Type Calcium Channels | Altered, Action Potential | Nov 20, 2024 | Nov 20, 2024 |
|
1756 | Decrease, Calcium currents | Decrease, Calcium binding to Troponin C | Jun 19, 2018 | Jun 19, 2018 |
|
1760 | Decrease, Calcium currents | Disruption, Intracellular calcium mobilization | Jun 21, 2018 | Jun 21, 2018 |
|
1757 | Decrease, Calcium binding to Troponin C | Decrease, Cardiac contractility | Jun 19, 2018 | Jun 19, 2018 |
|
1758 | Decrease, Cardiac contractility | Decrease, Cardiac ejection fraction | Jun 19, 2018 | Jun 19, 2018 |
|
3176 | Decrease, Cardiac contractility | Decrease LV function | Apr 3, 2024 | Apr 3, 2024 |
|
2824 | Decrease, Cardiac contractility | Heart failure | Jan 5, 2023 | Jan 5, 2023 |
|
1759 | Decrease, Cardiac ejection fraction | Heart failure | Jun 19, 2018 | Jun 19, 2018 |
|
2825 | Heart failure | Increase, Mortality | Jan 5, 2023 | Jan 5, 2023 | |
2514 | Heart failure | Altered mechanotransduction properties of pericytes | Oct 28, 2021 | Oct 28, 2021 | |
2508 | Heart failure | Upregulation of ACE2 | Oct 28, 2021 | Oct 28, 2021 | |
1761 | Disruption, Intracellular calcium mobilization | Disruption, Sarcomere assembly | Jun 21, 2018 | Jun 21, 2018 |
|
1762 | Disruption, Sarcomere assembly | Decrease, Cardiac contractility | Jun 21, 2018 | Jun 21, 2018 |
|
1766 | Protection against oxidative stress, decreased | Oxidative Stress | Sep 13, 2018 | Feb 7, 2020 |
|
1775 | Endocytosis | Disruption, Lysosome | Nov 12, 2018 | Nov 12, 2018 |
|
1790 | Mitochondrial Complex I inhibition | Increased reactive oxygen species (in the mitochondria) | Dec 19, 2018 | Mar 7, 2019 | |
1780 | Mitochondrial Complex I inhibition | Decrease in mitochondrial oxidative phosphorylation | Dec 19, 2018 | Mar 7, 2019 | |
1784 | Increase, Mitochondrial complex III antagonism | Increased reactive oxygen species (in the mitochondria) | Dec 19, 2018 | Mar 7, 2019 | |
1781 | Increase, Mitochondrial complex III antagonism | Decrease in mitochondrial oxidative phosphorylation | Dec 19, 2018 | Mar 7, 2019 |
|
1875 | Increase, Mitochondrial complex III antagonism | Increase, ROS formation | Mar 19, 2019 | Mar 19, 2019 | |
1872 | Increase, Mitochondrial complex III antagonism | Decrease, OXPHOS | Mar 19, 2019 | Mar 19, 2019 | |
2230 | Increase, Mitochondrial complex III antagonism | Decrease, ATP pool | Dec 4, 2020 | Dec 4, 2020 |
|
1785 | Mitochondrial Complex IV inhibition | Increased reactive oxygen species (in the mitochondria) | Dec 19, 2018 | Mar 7, 2019 | |
1782 | Mitochondrial Complex IV inhibition | Decrease in mitochondrial oxidative phosphorylation | Dec 19, 2018 | Mar 7, 2019 |
|
1786 | Mitochondrial Complex V inhibition | Increased reactive oxygen species (in the mitochondria) | Dec 19, 2018 | Dec 19, 2018 | |
1783 | Mitochondrial Complex V inhibition | Decrease in mitochondrial oxidative phosphorylation | Dec 19, 2018 | Mar 7, 2019 |
|
1787 | Decrease in mitochondrial oxidative phosphorylation | Mitochondrial Injury | Dec 19, 2018 | Mar 7, 2019 | |
1956 | Decrease in mitochondrial oxidative phosphorylation | Mitochondrial dysfunction | Jun 15, 2019 | Jun 15, 2019 |
|
1957 | Increased reactive oxygen species (in the mitochondria) | Mitochondrial dysfunction | Jun 15, 2019 | Jun 15, 2019 |
|
1788 | Increased reactive oxygen species (in the mitochondria) | Mitochondrial Injury | Dec 19, 2018 | Mar 7, 2019 | |
1941 | Mitochondrial Injury | Increased reactive oxygen species (in the mitochondria) | Jun 7, 2019 | Jun 7, 2019 | |
1942 | Mitochondrial Injury | Impaired, Proteostasis | Jun 7, 2019 | Jun 7, 2019 | |
3049 | Mitochondrial Injury | Increase, Cyt c release | Sep 14, 2023 | Sep 14, 2023 |
|
2715 | Mitochondrial Injury | Increase, Cell death | Jul 25, 2022 | Jul 25, 2022 | |
1789 | Necrotic Tissue | Liver Injury | Dec 19, 2018 | Mar 7, 2019 |
|
1798 | Ionizing Energy | Increase mutations | Dec 19, 2018 | Dec 19, 2018 | |
1799 | Ionizing Energy | Increase chromosomal aberrations | Dec 19, 2018 | Dec 19, 2018 | |
2392 | Ionizing Energy | Altered, Meiotic chromosome dynamics | May 14, 2021 | May 14, 2021 |
|
2394 | Ionizing Energy | impaired, Fertility | May 14, 2021 | May 14, 2021 |
|
2397 | Ionizing Energy | Increase, Oocyte apoptosis | May 14, 2021 | May 14, 2021 |
|
2396 | Ionizing Energy | Decreased, Population size | May 14, 2021 | May 14, 2021 |
|
2380 | Ionizing Energy | Increase, DNA Damage | May 12, 2021 | May 12, 2021 |
|
2395 | Ionizing Energy | Decrease of egg production and cummulative fecundity | May 14, 2021 | May 14, 2021 |
|
2379 | Ionizing Energy | Increased, Reactive oxygen species | May 12, 2021 | May 12, 2021 |
|
2393 | Ionizing Energy | Decreased spermatogenesis | May 14, 2021 | May 14, 2021 |
|
3240 | Ionizing Energy | Oxidative Stress | May 31, 2024 | May 31, 2024 |
|
1794 | DNA repair | Increase chromosomal aberrations | Dec 19, 2018 | Dec 19, 2018 | |
1793 | DNA repair | Increase mutations | Dec 19, 2018 | Dec 19, 2018 | |
1800 | Increase mutations | Increase, lung cancer | Dec 19, 2018 | Dec 19, 2018 | |
1795 | Increase mutations | Increase cell proliferation | Dec 19, 2018 | Dec 19, 2018 | |
1900 | Increase mutations | Increase, Cell Proliferation (Epithelial Cells) | May 7, 2019 | May 7, 2019 | |
3237 | Increase mutations | Increase, Cancer | May 28, 2024 | May 28, 2024 |
|
1801 | Increase chromosomal aberrations | Increase, lung cancer | Dec 19, 2018 | Dec 19, 2018 | |
1796 | Increase chromosomal aberrations | Increase cell proliferation | Dec 19, 2018 | Dec 19, 2018 | |
2729 | Increase chromosomal aberrations | Increase,miRNA levels | Aug 14, 2022 | Aug 27, 2023 |
|
1797 | Increase cell proliferation | Increase, lung cancer | Dec 19, 2018 | Dec 19, 2018 | |
1803 | Reduced neural crest cell migration | Reduced collagen production | Dec 20, 2018 | Dec 20, 2018 |
|
2563 | Reduced neural crest cell migration | Transposition of the great arteries | Feb 8, 2022 | Feb 15, 2022 |
|
1804 | Reduced collagen production | Smaller and morphologically distorted facial cartilage structures | Dec 20, 2018 | Dec 20, 2018 |
|
2686 | Smaller and morphologically distorted facial cartilage structures | Increase, Early Life Stage Mortality | Jun 30, 2022 | Apr 13, 2023 |
|
1808 | Altered differentiation | Neural tube defects | Dec 20, 2018 | Dec 20, 2018 |
|
2603 | Altered differentiation | Microcephaly | Mar 17, 2022 | Mar 17, 2022 | |
1811 | Decreased Na/K ATPase activity | Decreased proximal tubular vectorial transport | Dec 20, 2018 | Dec 20, 2018 |
|
3444 | Decreased Na/K ATPase activity | Increased, intracellular sodium (Na+) | Nov 26, 2024 | Nov 26, 2024 |
|
3287 | Decreased Na/K ATPase activity | Decreased, sodium uptake in gills | Jul 8, 2024 | Dec 3, 2024 |
|
2787 | Decreased Na/K ATPase activity | Increase, Cell membrane depolarization | Oct 19, 2022 | Oct 19, 2022 |
|
1812 | Decreased proximal tubular vectorial transport | Chemical induced Fanconi syndrome | Dec 20, 2018 | Dec 20, 2018 |
|
1817 | Suppressed AP-1 | Suppressed DC activation | Dec 25, 2018 | Dec 25, 2018 | |
1818 | Suppressed NF-kB | Suppressed DC activation | Dec 25, 2018 | Dec 25, 2018 | |
1819 | Suppressed DC activation | Impaired antigen presentation | Dec 25, 2018 | Dec 25, 2018 | |
1820 | Impaired antigen presentation | Impaired T cell activation | Dec 25, 2018 | Dec 25, 2018 | |
1822 | Impaired T cell activation | Impairment of TDAR | Dec 25, 2018 | Jun 1, 2019 | |
1821 | Impaired T cell activation | Suppression, Suppression of T-cell dependent antibody response (TDAR) | Dec 25, 2018 | Dec 25, 2018 | |
1922 | Impaired T cell activation | Impaired Ab production | May 23, 2019 | Jun 25, 2019 | |
1813 | Blocking of IL-1R | Impaired IL-1 signaling | Dec 24, 2018 | Jun 25, 2019 | |
1814 | Decreased IL-1 production | Impaired IL-1 signaling | Dec 25, 2018 | Jun 25, 2019 | |
1824 | Decreased IL-1 production | Suppressed MyD88 | Jan 6, 2019 | Jan 6, 2019 | |
1825 | Impaired IL-1 signaling | Suppressed MyD88 | Jan 6, 2019 | Mar 14, 2019 | |
1816 | Impaired IL-1 signaling | Suppressed NF-kB | Dec 25, 2018 | Dec 25, 2018 | |
1815 | Impaired IL-1 signaling | Suppressed AP-1 | Dec 25, 2018 | Dec 25, 2018 | |
1920 | Impaired IL-1 signaling | Inhibition, Nuclear factor kappa B (NF-kB) | May 23, 2019 | Jun 25, 2019 | |
1826 | Suppressed MyD88 | Impairment of TDAR | Jan 6, 2019 | Jan 6, 2019 | |
1870 | Suppressed MyD88 | Inhibition, Nuclear factor kappa B (NF-kB) | Mar 12, 2019 | Mar 12, 2019 | |
1827 | Inhibition, IKK complex | Inhibition, Nuclear factor kappa B (NF-kB) | Jan 7, 2019 | Mar 7, 2019 |
|
1829 | Activation, Caspase 8 pathway | Cell injury/death | Jan 7, 2019 | Mar 7, 2019 |
|
1832 | Activation, Tissue resident cells (Kuppfer cells) | Increase, proinflammatory mediators (TNFalpha) | Jan 7, 2019 | Jan 7, 2019 |
|
1833 | Binding of MSAs to microtubules | Disturbance in microtubule dynamic instability | Jan 29, 2019 | Jan 29, 2019 |
|
1834 | Disturbance in microtubule dynamic instability | Impaired axonial transport | Jan 29, 2019 | Jan 29, 2019 |
|
1835 | Impaired axonial transport | Sensory axonal peripheral neuropathy | Jan 29, 2019 | Jan 29, 2019 |
|
2506 | Impaired axonial transport | Dysfunctional synapses | Oct 26, 2021 | Oct 26, 2021 |
|
2657 | Sensory axonal peripheral neuropathy | Increased Mortality | May 16, 2022 | May 16, 2022 |
|
3066 | Sensory axonal peripheral neuropathy | Decreased, Neuronal network function in adult brain | Oct 17, 2023 | Oct 17, 2023 |
|
3067 | Sensory axonal peripheral neuropathy | Overactivation, NMDARs | Oct 17, 2023 | Oct 17, 2023 | |
1836 | Interaction of α-diketones with arginine residues | Proteasomal dysfunction | Jan 30, 2019 | Jan 30, 2019 |
|
1837 | Proteasomal dysfunction | Airway epithelial injury | Jan 30, 2019 | Jan 30, 2019 |
|
3044 | Proteasomal dysfunction | Accumulation, misfolded proteins | Sep 14, 2023 | Sep 14, 2023 |
|
1838 | Airway epithelial injury | Increase, Inflammation | Jan 30, 2019 | Jan 30, 2019 |
|
1841 | Fibroproliferative airway lesions | Bronchiolitis obliterans | Jan 30, 2019 | Jan 30, 2019 |
|
1842 | Distribution of chemicals | Absorption of photon energy | Feb 4, 2019 | Feb 4, 2019 | |
1843 | Absorption of photon energy | ROS generation | Feb 4, 2019 | Feb 4, 2019 | |
1844 | Absorption of photon energy | Radical generation | Feb 4, 2019 | Feb 4, 2019 | |
1845 | ROS generation | Oxidation of membrane lipids | Feb 4, 2019 | Jul 9, 2019 |
|
1846 | ROS generation | Oxidation/denatuation of membrane proteins | Feb 4, 2019 | Jul 9, 2019 |
|
1847 | ROS generation | Oxidation of DNA | Feb 4, 2019 | Feb 4, 2019 | |
1849 | Radical generation | Protein photo-adducts | Feb 4, 2019 | Feb 4, 2019 | |
1848 | Radical generation | DNA photo-adducts | Feb 4, 2019 | Feb 4, 2019 | |
1850 | Oxidation of membrane lipids | Inflammatory events | Feb 4, 2019 | Jul 9, 2019 |
|
1851 | Oxidation/denatuation of membrane proteins | Inflammatory events | Feb 4, 2019 | Jul 9, 2019 |
|
1852 | Oxidation of DNA | Inflammatory events | Feb 4, 2019 | Feb 4, 2019 | |
1853 | DNA photo-adducts | Inflammatory events | Feb 4, 2019 | Feb 4, 2019 | |
1854 | Protein photo-adducts | Inflammatory events | Feb 4, 2019 | Feb 4, 2019 | |
1855 | Inflammatory events | Eczematous eruption | Feb 4, 2019 | Feb 4, 2019 | |
2916 | Inflammatory events | Increased, Invasion | May 11, 2023 | May 11, 2023 |
|
2917 | Inflammatory events | prostatic intraepithelial neoplasia | May 11, 2023 | May 11, 2023 |
|
1856 | Eczematous eruption | Scaling, Lichenification | Feb 4, 2019 | Feb 4, 2019 | |
1858 | Activation, Muscarinic Acetylcholine Receptors | Increased, glutamate | Feb 13, 2019 | Feb 13, 2019 | |
1889 | Activation, Muscarinic Acetylcholine Receptors | Occurrence, Focal Seizure | Apr 22, 2019 | Sep 3, 2023 |
|
3402 | Activation, Muscarinic Acetylcholine Receptors | Increased, blood potassium concentration | Nov 20, 2024 | Nov 20, 2024 |
|
3431 | Activation, Muscarinic Acetylcholine Receptors | Altered, Action Potential | Nov 22, 2024 | Nov 22, 2024 |
|
1864 | Inhibition of N-linked glycosylation | Accumulation, misfolded proteins | Mar 6, 2019 | Mar 6, 2019 |
|
1865 | Accumulation, misfolded proteins | Unfolded Protein Response | Mar 6, 2019 | Mar 6, 2019 |
|
3045 | Accumulation, misfolded proteins | Endoplasmic reticulum stress | Sep 14, 2023 | Sep 14, 2023 |
|
3046 | Accumulation, misfolded proteins | Caspase activation | Sep 14, 2023 | Sep 14, 2023 |
|
1868 | Activation, hepatic stellate cells | Liver Injury | Mar 6, 2019 | Mar 6, 2019 |
|
1874 | Increase, Necrosis | Increase, Mortality | Mar 19, 2019 | Mar 19, 2019 | |
2177 | Increase, Necrosis | Increase, Tissue/organ damage | Nov 2, 2020 | Nov 2, 2020 | |
2465 | Increase, Necrosis | Increased, Kidney Failure | Aug 11, 2021 | Aug 11, 2021 |
|
2122 | Increase, Necrosis | Increase, Ovarian follicle breakdown | May 8, 2020 | May 8, 2020 | |
1878 | Inhibition of Cyp17A1 activity | Reduction, DHEA | Apr 10, 2019 | Apr 10, 2019 |
|
1879 | Inhibition of Cyp17A1 activity | Reduction, androstenedione | Apr 10, 2019 | Apr 10, 2019 |
|
3228 | Reduction, DHEA | Decrease, circulating testosterone levels | May 24, 2024 | May 24, 2024 |
|
3229 | Reduction, androstenedione | Decrease, circulating testosterone levels | May 24, 2024 | May 24, 2024 |
|
3172 | Decrease, DHT level | Impaired, urethral tube closure | Mar 20, 2024 | Dec 3, 2024 |
|
1881 | Decrease, DHT level | Reduction, Plasma 17beta-estradiol concentrations | Apr 18, 2019 | Apr 18, 2019 |
|
1935 | Decrease, DHT level | Decrease, AR activation | Jun 3, 2019 | Apr 5, 2024 |
|
1937 | Decrease, AR activation | Impaired inguinoscrotal phase | Jun 3, 2019 | Jun 3, 2019 |
|
3348 | Decrease, AR activation | nipple retention, increased | Sep 26, 2024 | Sep 26, 2024 | |
2128 | Decrease, AR activation | decrease, transcription of genes by AR | May 11, 2020 | Nov 2, 2020 | |
2124 | Decrease, AR activation | Altered, Transcription of genes by the AR | May 11, 2020 | Apr 5, 2024 |
|
2820 | Decrease, AR activation | AGD, decreased | Dec 22, 2022 | Aug 8, 2024 |
|
2828 | Decrease, AR activation | Hypospadias | Jan 11, 2023 | Jan 11, 2023 |
|
1938 | Impaired inguinoscrotal phase | Malformation, cryptorchidism | Jun 3, 2019 | Dec 3, 2024 |
|
1880 | Inhibition, 5α-reductase | Decrease, DHT level | Apr 18, 2019 | Apr 5, 2024 |
|
1883 | Increase, DNMT inhibition | Increase, DNA hypomethylation | Apr 22, 2019 | Apr 22, 2019 | |
2101 | Increase, DNMT inhibition | Decrease, Global DNA methylation | Apr 30, 2020 | Apr 30, 2020 |
|
3098 | Increase, DNMT inhibition | Increase, DSB | Nov 16, 2023 | Nov 16, 2023 |
|
3305 | Increase, DNMT inhibition | EMT | Jul 18, 2024 | Jul 18, 2024 |
|
1887 | Increase, DNA hypomethylation | Decrease, Transgenerational DNA methylation | Apr 22, 2019 | Apr 22, 2019 | |
1884 | Increase, DNA hypomethylation | Increase, Gene expression | Apr 22, 2019 | Apr 22, 2019 | |
1885 | Increase, Gene expression | Decrease, Fecundity | Apr 22, 2019 | Apr 22, 2019 | |
1888 | Decrease, Transgenerational DNA methylation | Increase, Gene expression | Apr 22, 2019 | Apr 22, 2019 | |
1890 | Occurrence, Focal Seizure | Increased, glutamate | Apr 22, 2019 | Sep 3, 2023 |
|
1998 | Occurrence, Focal Seizure | Overactivation, NMDARs | Nov 13, 2019 | Nov 13, 2019 | |
1891 | tyrosinase | Reduction of L-Dopaquinone | May 3, 2019 | May 3, 2019 |
|
1892 | Reduction of L-Dopaquinone | Reduction in melanin level | May 3, 2019 | May 3, 2019 |
|
1893 | Reduction in melanin level | Reduction of melanosome level | May 3, 2019 | May 3, 2019 |
|
1894 | Reduction of melanosome level | Reduction fo Pigmentation pattern | May 3, 2019 | May 3, 2019 |
|
1895 | Reduction fo Pigmentation pattern | Decrease, Population growth rate | May 3, 2019 | May 3, 2019 |
|
1904 | Increase in RONS | Increase, DNA Damage | May 7, 2019 | May 8, 2019 |
|
1906 | Increase in RONS | Tissue resident cell activation | May 7, 2019 | May 9, 2019 |
|
2798 | Increase in RONS | methemocyanin formation (decrease overall oxygen binding capacity) | Nov 16, 2022 | Nov 16, 2022 |
|
3268 | Increase in RONS | Oxidative Stress | Jul 4, 2024 | Jul 4, 2024 |
|
2337 | Increase in RONS | Decrease, MMP | Apr 11, 2021 | Apr 11, 2021 | |
2331 | Increase in RONS | D1 protein deactivation | Apr 11, 2021 | Apr 11, 2021 | |
2199 | Increase in inflammation | hepatitis | Nov 2, 2020 | Nov 2, 2020 |
|
3177 | Increase in inflammation | Insulin resistance, increased | Apr 9, 2024 | Apr 9, 2024 |
|
2646 | Increase in inflammation | Occurrence, renal proximal tubular necrosis | Apr 8, 2022 | Apr 8, 2022 |
|
1909 | Increase, Oxidative DNA damage | Inadequate DNA repair | May 19, 2019 | Mar 8, 2024 |
|
1914 | Increase, Oxidative DNA damage | Increase, Mutations | May 19, 2019 | Jan 9, 2023 |
|
1913 | Increase, Oxidative DNA damage | Increase, DNA strand breaks | May 19, 2019 | Mar 8, 2024 |
|
2591 | Increase, Oxidative DNA damage | Increase, Follicular atresia | Mar 1, 2022 | Mar 1, 2022 |
|
2592 | Increase, Oxidative DNA damage | Increase, Oocyte apoptosis | Mar 1, 2022 | Mar 1, 2022 |
|
3230 | Increase, Oxidative DNA damage | Increase, DSB | May 27, 2024 | May 27, 2024 |
|
3232 | Increase, Oxidative DNA damage | Increase, Apoptosis | May 27, 2024 | May 27, 2024 | |
3362 | Increase, Oxidative DNA damage | Cell cycle, disrupted | Oct 8, 2024 | Oct 8, 2024 |
|
3359 | Increase, Oxidative DNA damage | Cell injury/death | Oct 8, 2024 | Oct 8, 2024 |
|
3315 | Increase, DNA strand breaks | Altered Stress Response Signaling | Jul 24, 2024 | Aug 26, 2024 |
|
1931 | Increase, DNA strand breaks | Increase, Mutations | Jun 2, 2019 | Jan 9, 2023 |
|
1911 | Increase, DNA strand breaks | Inadequate DNA repair | May 19, 2019 | Mar 8, 2024 |
|
1939 | Increase, DNA strand breaks | Increase, Chromosomal aberrations | Jun 3, 2019 | Jan 9, 2023 |
|
2856 | Increase, DNA strand breaks | Altered Signaling | Mar 10, 2023 | Mar 21, 2023 | |
2841 | Increase, DNA strand breaks | Abnormal Neural Remodeling | Jan 25, 2023 | Jul 29, 2024 |
|
2589 | Increase, DNA strand breaks | Increase, Oocyte apoptosis | Mar 1, 2022 | Mar 1, 2022 |
|
2587 | Increase, DNA strand breaks | Increase, Follicular atresia | Mar 1, 2022 | Mar 1, 2022 |
|
2074 | Increase, DNA strand breaks | Increase, Apoptosis | Apr 6, 2020 | Apr 6, 2020 |
|
1985 | Increase, Chromosomal aberrations | Increase, lung cancer | Aug 29, 2019 | Jan 10, 2023 |
|
1979 | Increase, Chromosomal aberrations | Increase, Cell Proliferation | Aug 29, 2019 | Mar 8, 2024 |
|
1915 | Retinaldehyde dehydrogenase | retinoic acid | May 22, 2019 | May 22, 2019 |
|
1918 | Altered, Photoreceptor patterning | Altered, Visual function | May 22, 2019 | Jun 16, 2021 |
|
1916 | retinoic acid | plasma retionic acid | May 22, 2019 | May 22, 2019 |
|
1917 | plasma retionic acid | Altered, Photoreceptor patterning | May 22, 2019 | May 22, 2019 |
|
1919 | Altered, Visual function | Decline, Population | May 22, 2019 | May 22, 2019 | |
2143 | Altered, Visual function | Decrease, Population growth rate | May 25, 2020 | May 25, 2020 |
|
2375 | Altered, Visual function | Increased Mortality | May 11, 2021 | Jul 8, 2022 |
|
1923 | Impaired Ab production | Impairment of TDAR | May 23, 2019 | Jun 25, 2019 | |
1924 | Wnt ligand stimulation | Frizzled activation | May 29, 2019 | May 29, 2019 | |
1925 | Frizzled activation | GSK3beta inactivation | May 29, 2019 | May 29, 2019 | |
1926 | GSK3beta inactivation | β-catenin activation | May 29, 2019 | May 29, 2019 | |
2485 | GSK3beta inactivation | Repression of Gbx2 expression | Oct 3, 2021 | Dec 12, 2021 |
|
1927 | β-catenin activation | Snail, Zeb, Twist activation | May 29, 2019 | May 29, 2019 | |
1930 | Increase, SAM depletion | Increase, DNA hypomethylation | May 30, 2019 | May 30, 2019 | |
1944 | Binding of inhibitor, mitochondrial complex III | Increase, Mitochondrial complex III antagonism | Jun 7, 2019 | Jun 7, 2019 |
|
1945 | Binding of inhibitor, mitochondrial complex IV | Mitochondrial Complex IV inhibition | Jun 7, 2019 | Jun 7, 2019 |
|
1946 | Binding of inhibitor, mitochondrial complex V | Mitochondrial Complex V inhibition | Jun 7, 2019 | Jun 7, 2019 |
|
1947 | TR Antagnoism | Hippocampal gene expression, Altered | Jun 8, 2019 | Jun 8, 2019 |
|
1948 | TR Antagnoism | Cognitive function, decreased | Jun 8, 2019 | Jun 8, 2019 |
|
3193 | TR Antagnoism | Hypomyelination | Apr 12, 2024 | Apr 12, 2024 |
|
3186 | TR Antagnoism | Reduced number of oligodendrocytes | Apr 12, 2024 | Apr 12, 2024 |
|
1949 | CBS inhibition | Homocysteine increases | Jun 14, 2019 | Jun 14, 2019 |
|
1951 | Methionine synthase | Homocysteine increases | Jun 14, 2019 | Jun 14, 2019 | |
1950 | MTHFR inhibition | Homocysteine increases | Jun 14, 2019 | Jun 14, 2019 | |
1952 | betaine-homocysteine methyltransferase inhibition | Homocysteine increases | Jun 14, 2019 | Jun 14, 2019 | |
1953 | Homocysteine increases | plasma homocysteine increases | Jun 14, 2019 | Jun 14, 2019 | |
1959 | Homocysteine increases | Plasma HCY level | Jul 3, 2019 | Jul 3, 2019 |
|
1954 | plasma homocysteine increases | brain Homocysteine level increases | Jun 14, 2019 | Jun 14, 2019 | |
1955 | brain Homocysteine level increases | Neuronal dysfunctions induction | Jun 14, 2019 | Jun 14, 2019 | |
1960 | Plasma HCY level | dysfunction of microcirculation | Jul 3, 2019 | Jul 3, 2019 |
|
1961 | dysfunction of microcirculation | anterior-posterior axis development | Jul 3, 2019 | Jul 3, 2019 |
|
2512 | dysfunction of microcirculation | Increased inflammatory immune responses | Oct 28, 2021 | Oct 28, 2021 | |
2415 | Frustrated phagocytosis | Increased proinflammatory mediators | Jul 6, 2021 | Jul 6, 2021 |
|
2416 | Frustrated phagocytosis | Increased, Reactive oxygen species | Jul 6, 2021 | Jul 6, 2021 |
|
1962 | Frustrated phagocytosis | Release, Cytokine | Jul 3, 2019 | Aug 13, 2019 |
|
1966 | Increased, DNA damage and mutation | Increase, Cell Proliferation | Jul 3, 2019 | Jul 3, 2019 |
|
2608 | Increased, DNA damage and mutation | Inadequate DNA repair | Mar 22, 2022 | Aug 27, 2023 |
|
2728 | Increased, DNA damage and mutation | Increase chromosomal aberrations | Aug 14, 2022 | Aug 27, 2023 |
|
2417 | Increased, DNA damage and mutation | Genomic instability | Jul 6, 2021 | Jul 6, 2021 |
|
1968 | Substance - LS interaction | Inhibition of LS function. | Jul 3, 2019 | Jul 3, 2019 | |
1969 | Inhibition of LS function. | Alveolar collapse | Jul 3, 2019 | Jul 3, 2019 |
|
2255 | Inhibition of LS function. | Loss of alveolar capillary membrane integrity | Jan 8, 2021 | Jan 8, 2021 | |
2256 | Inhibition of LS function. | Reduced tidal volume | Jan 8, 2021 | Jan 8, 2021 | |
2370 | Inhibition of LS function. | Decreased lung function | Apr 27, 2021 | Apr 27, 2021 |
|
2371 | Alveolar collapse | Decreased lung function | Apr 27, 2021 | Apr 27, 2021 |
|
2284 | Alveolar collapse | Loss of alveolar capillary membrane integrity | Feb 16, 2021 | Feb 1, 2022 |
|
2285 | Alveolar collapse | Impaired lung function | Feb 16, 2021 | Feb 16, 2021 | |
1970 | Alveolar collapse | Alveolar reopening | Jul 3, 2019 | Jul 3, 2019 | |
1974 | Alveolar collapse | Reduced tidal volume | Jul 3, 2019 | Jul 3, 2019 |
|
1971 | Alveolar reopening | Loss of barrier function | Jul 3, 2019 | Jul 3, 2019 | |
2173 | Alveolar reopening | Loss of alveolar capillary membrane integrity | Oct 22, 2020 | Oct 22, 2020 | |
1972 | Loss of barrier function | Blood extravasation into the lungs | Jul 3, 2019 | Jul 3, 2019 | |
1973 | Blood extravasation into the lungs | Acute inhalation toxicity | Jul 3, 2019 | Jul 3, 2019 | |
1975 | Reduced tidal volume | Impaired oxygenation of the blood | Jul 3, 2019 | Jul 3, 2019 | |
2257 | Reduced tidal volume | Impaired lung function | Jan 8, 2021 | Jan 8, 2021 | |
2367 | Reduced tidal volume | Decreased lung function | Apr 27, 2021 | Apr 27, 2021 |
|
1976 | Impaired oxygenation of the blood | Acute inhalation toxicity | Jul 3, 2019 | Jul 3, 2019 | |
2562 | Disruption, Progenitor cells of second heart field | Reduced neural crest cell migration | Feb 8, 2022 | Feb 10, 2022 |
|
2557 | Energy Deposition | Increase, ROS | Feb 4, 2022 | Feb 4, 2022 |
|
2552 | Energy Deposition | Increase, DNA Damage | Jan 21, 2022 | Jan 21, 2022 |
|
2548 | Energy Deposition | Increased, Reactive oxygen species | Jan 21, 2022 | Jan 21, 2022 |
|
2604 | Energy Deposition | Microcephaly | Mar 17, 2022 | Mar 17, 2022 |
|
1977 | Energy Deposition | Increase, DNA strand breaks | Aug 26, 2019 | Jul 29, 2024 |
|
1981 | Energy Deposition | Increase, Mutations | Aug 29, 2019 | Mar 8, 2024 |
|
1982 | Energy Deposition | Increase, Chromosomal aberrations | Aug 29, 2019 | Mar 8, 2024 |
|
1983 | Energy Deposition | Increase, lung cancer | Aug 29, 2019 | Jul 5, 2023 |
|
2616 | Energy Deposition | Increase in RONS | Mar 28, 2022 | Mar 28, 2022 |
|
2785 | Energy Deposition | Occurrence, Abnormal Vascular Remodeling | Oct 17, 2022 | Aug 26, 2024 |
|
2780 | Energy Deposition | Increase, Endothelial Dysfunction | Sep 28, 2022 | Aug 26, 2024 |
|
2769 | Energy Deposition | Oxidative Stress | Sep 28, 2022 | Aug 26, 2024 |
|
2770 | Energy Deposition | Vascular remodeling | Sep 28, 2022 | Sep 28, 2022 | |
2809 | Energy Deposition | Modified Proteins | Dec 16, 2022 | Mar 8, 2024 |
|
2813 | Energy Deposition | Increase, Oxidative DNA damage | Dec 18, 2022 | Mar 8, 2024 |
|
2814 | Energy Deposition | Increase, Cell Proliferation | Dec 18, 2022 | Mar 8, 2024 |
|
2779 | Energy Deposition | Altered, Nitric Oxide Levels | Sep 28, 2022 | Aug 26, 2024 |
|
2847 | Energy Deposition | Altered Bone Cell Homeostasis | Jan 25, 2023 | Aug 9, 2024 |
|
2848 | Energy Deposition | Bone Remodeling | Jan 25, 2023 | Aug 9, 2024 |
|
2849 | Energy Deposition | Bone Loss | Jan 25, 2023 | Aug 12, 2024 |
|
2837 | Energy Deposition | Abnormal Neural Remodeling | Jan 25, 2023 | Jul 26, 2024 |
|
2838 | Energy Deposition | Impairment, Learning and memory | Jan 25, 2023 | Jul 26, 2024 |
|
2815 | Energy Deposition | Cataracts | Dec 18, 2022 | Mar 11, 2024 |
|
2832 | Energy Deposition | Tissue resident cell activation | Jan 25, 2023 | Jul 26, 2024 |
|
2129 | decrease, transcription of genes by AR | AGD, decreased | May 11, 2020 | May 11, 2020 | |
2131 | Decrease, circulating testosterone levels | Decrease, AR activation | May 11, 2020 | Apr 5, 2024 |
|
2126 | Decrease, circulating testosterone levels | Decrease, DHT level | May 11, 2020 | Oct 19, 2023 |
|
3225 | Decrease, circulating testosterone levels | Decreased sperm quantity or quality in the adult, Decreased fertility | May 24, 2024 | May 24, 2024 |
|
3227 | Decrease, circulating testosterone levels | Increased, Leutinizing hormone (LH) | May 24, 2024 | May 24, 2024 |
|
3214 | Decrease, circulating testosterone levels | Reduction, the ratio of E2/11-KT in plasma | May 8, 2024 | May 8, 2024 |
|
3213 | Decrease, circulating testosterone levels | Reduction, Plasma 17beta-estradiol concentrations | May 8, 2024 | May 8, 2024 |
|
3205 | Decrease, circulating testosterone levels | Malformation, Male reproductive tract | May 1, 2024 | May 1, 2024 |
|
3206 | Decrease, circulating testosterone levels | Increase, Luteinizing hormone (LH) | May 1, 2024 | May 1, 2024 |
|
3202 | Decrease, circulating testosterone levels | malformed, Male reproductive tract | Apr 25, 2024 | Apr 25, 2024 |
|
3169 | Decrease, circulating testosterone levels | Epididymal agenesis | Mar 20, 2024 | Dec 3, 2024 |
|
3350 | Decrease, circulating testosterone levels | Hypospadias | Oct 1, 2024 | Oct 1, 2024 | |
3349 | Decrease, circulating testosterone levels | AGD, decreased | Oct 1, 2024 | Oct 1, 2024 | |
1986 | Antagonism,LH receptor | Reduction, Progesterone synthesis | Oct 3, 2019 | Oct 3, 2019 |
|
1987 | Reduction, Progesterone synthesis | Reduction, Plasma progesterone concentration | Oct 3, 2019 | Oct 3, 2019 |
|
1988 | Reduction, Plasma progesterone concentration | Reduction, progesterone uptake, decresed maturation | Oct 3, 2019 | Oct 3, 2019 |
|
1989 | Reduction, progesterone uptake, decresed maturation | Impaired ovulation | Oct 3, 2019 | Oct 3, 2019 |
|
1990 | Impaired ovulation | Decrease of egg production and cummulative fecundity | Oct 3, 2019 | Oct 3, 2019 |
|
1991 | Decrease of egg production and cummulative fecundity | Decline, Population trajectory | Oct 3, 2019 | Oct 3, 2019 |
|
2389 | Decrease of egg production and cummulative fecundity | Decreased, Population size | May 12, 2021 | May 12, 2021 |
|
1993 | Increase, DNMT expression | Increase, hypermethylation of the promotor region of GnRHR | Oct 30, 2019 | Oct 30, 2019 |
|
1994 | Increase, hypermethylation of the promotor region of GnRHR | Decease, expression of GnRHR | Oct 30, 2019 | Oct 30, 2019 |
|
1995 | Decease, expression of GnRHR | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | Oct 30, 2019 | Oct 30, 2019 |
|
2002 | Impaired IL-1R1 signaling | Inhibition, Nuclear factor kappa B (NF-kB) | Nov 17, 2019 | Sep 29, 2022 |
|
2000 | Impaired IL-1R1 signaling | Suppression of T cell activation | Nov 17, 2019 | Nov 17, 2019 | |
2001 | Suppression of T cell activation | Inhibition, Nuclear factor kappa B (NF-kB) | Nov 17, 2019 | Nov 17, 2019 | |
2004 | Suppression of T cell activation | Impairment of TDAR | Nov 17, 2019 | Mar 2, 2023 | |
2928 | Suppression of T cell activation | Impairment, T-cell dependent antibody response | May 24, 2023 | May 25, 2023 |
|
2927 | Suppression of T cell activation | Impaired IL-1R1 signaling | May 24, 2023 | May 24, 2023 | |
2006 | Cardiovascular dysregulation | Respiratory distress/arrest | Nov 25, 2019 | Dec 19, 2019 |
|
2034 | test | Unknown, MIE | Jan 26, 2020 | Jan 26, 2020 | |
2037 | test | N/A, Unknown | Jan 26, 2020 | Jan 26, 2020 | |
2012 | Impaired coordination and movement | Increased Mortality | Dec 20, 2019 | Dec 20, 2019 |
|
2015 | Impaired coordination and movement | Decrease, Population growth rate | Dec 20, 2019 | Dec 20, 2019 |
|
2017 | Stimulation of TLR7/8 | Increase of IL-23 | Dec 27, 2019 | Dec 27, 2019 |
|
2018 | Increase of IL-23 | Th17 cell migration and inflammation induction | Dec 27, 2019 | Dec 27, 2019 |
|
2019 | Th17 cell migration and inflammation induction | Skin disease | Dec 27, 2019 | Dec 27, 2019 |
|
2020 | Binding to estrogen receptor (ER)-α | Induction of GATA3 expression | Dec 29, 2019 | Aug 14, 2020 |
|
2021 | Induction of GATA3 expression | Increase of Th2 cells producing IL-4 | Dec 29, 2019 | Aug 14, 2020 |
|
2022 | Increase of Th2 cells producing IL-4 | Increase of autoantibody production | Dec 29, 2019 | Aug 14, 2020 |
|
2023 | Increase of autoantibody production | Exacerbation of SLE | Dec 29, 2019 | Aug 14, 2020 |
|
2024 | Inhibition of JAK3 | STAT5 inhibition | Jan 5, 2020 | Nov 3, 2021 |
|
2025 | STAT5 inhibition | Suppression of STAT5 binding to cytokine gene promoters | Jan 5, 2020 | Nov 3, 2021 |
|
2026 | Suppression of STAT5 binding to cytokine gene promoters | Suppression of IL-4 production | Jan 5, 2020 | Mar 30, 2021 |
|
2027 | Suppression of IL-4 production | Impairment, TDAR | Jan 5, 2020 | Apr 4, 2021 |
|
2028 | Inhibition, trypsin | Increased monitor peptide | Jan 8, 2020 | Jan 8, 2020 |
|
2029 | Increased monitor peptide | Increased blood CCK level | Jan 8, 2020 | Jan 8, 2020 |
|
2030 | Increased blood CCK level | Increased acinar cell exocrine secretion | Jan 8, 2020 | Jan 8, 2020 |
|
2031 | Increased acinar cell exocrine secretion | Acinar cell proliferation | Jan 8, 2020 | Jan 8, 2020 |
|
2032 | Acinar cell proliferation | Acinar cell tumors | Jan 8, 2020 | Jan 8, 2020 |
|
2052 | SARS-CoV-2 cell entry | Increased proinflammatory mediators | Mar 1, 2020 | Mar 1, 2020 | |
2510 | SARS-CoV-2 cell entry | Endothelial cell dysfunction | Oct 28, 2021 | Oct 28, 2021 | |
2496 | SARS-CoV-2 cell entry | IFN-I response, antagonized | Oct 24, 2021 | Dec 12, 2023 |
|
2361 | SARS-CoV-2 cell entry | Sustentacular cells, decrease | Apr 26, 2021 | Apr 26, 2021 | |
2314 | SARS-CoV-2 cell entry | Increased viral transcription and replication | Apr 9, 2021 | Apr 9, 2021 | |
2310 | SARS-CoV-2 cell entry | SARS-CoV-2 production | Mar 30, 2021 | Feb 7, 2023 |
|
2302 | SARS-CoV-2 cell entry | TLR Activation/Dysregulation | Mar 29, 2021 | Mar 29, 2021 | |
2294 | Binding to ACE2 | Induced, Angiotensin (Ang) II accumulation | Mar 28, 2021 | Mar 28, 2021 | |
2297 | Binding to ACE2 | Increased AngII | Mar 28, 2021 | Mar 28, 2021 | |
2286 | Binding to ACE2 | Neuroinflammation | Feb 23, 2021 | Feb 23, 2021 |
|
2299 | Binding to ACE2 | ACE2 enzymatic inhibition | Mar 28, 2021 | Mar 28, 2021 | |
2452 | Binding to ACE2 | Endothelial cell dysfunction | Aug 4, 2021 | Aug 4, 2021 | |
2312 | Binding to ACE2 | Downregulation of ACE2 | Mar 31, 2021 | Nov 12, 2021 |
|
2311 | Binding to ACE2 | ACE2 dysregulation | Mar 31, 2021 | Feb 7, 2023 |
|
2522 | Binding to ACE2 | ADAM17 induction | Oct 28, 2021 | Oct 28, 2021 | |
2056 | Binding to ACE2 | SARS-CoV-2 cell entry | Mar 2, 2020 | Oct 21, 2024 |
|
2065 | ACE2 enzymatic inhibition | Increased AngII | Mar 17, 2020 | Mar 17, 2020 |
|
2321 | ACE2 enzymatic inhibition | Induced, Angiotensin (Ang) II accumulation | Apr 10, 2021 | Apr 10, 2021 | |
2434 | ACE2 enzymatic inhibition | Increase plasma Ang II | Jul 13, 2021 | Jul 13, 2021 |
|
2322 | Induced, Angiotensin (Ang) II accumulation | Increased Ang II type 1 receptor (AT1R) | Apr 10, 2021 | Apr 10, 2021 | |
2295 | Induced, Angiotensin (Ang) II accumulation | Impaired gustatory nerve | Mar 28, 2021 | Mar 28, 2021 | |
2520 | Induced, Angiotensin (Ang) II accumulation | Hyperactivation of ACE/Ang-II/AT1R axis | Oct 28, 2021 | Oct 28, 2021 | |
2435 | Increase plasma Ang II | Increased Ang II type 1 receptor (AT1R) | Jul 13, 2021 | Jul 13, 2021 |
|
2067 | Increase plasma Ang II | Increase,collagen synthesis | Mar 17, 2020 | Mar 17, 2020 | |
2138 | Increase plasma Ang II | Accumulation, Collagen | May 15, 2020 | May 15, 2020 | |
2068 | Increase,collagen synthesis | Induction lung fibrosis | Mar 17, 2020 | Mar 17, 2020 | |
2064 | Increase, the risk of acute respiratory failure | Decreased mortality | Mar 17, 2020 | Mar 17, 2020 | |
2135 | Increase, the risk of acute respiratory failure | Increased Mortality | May 13, 2020 | May 13, 2020 |
|
2062 | Increased inflammatory immune responses | Increase, the risk of acute respiratory failure | Mar 10, 2020 | Mar 10, 2020 |
|
2513 | Increased inflammatory immune responses | Heart attack | Oct 28, 2021 | Oct 28, 2021 | |
2593 | Increased AngII | Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) | Mar 3, 2022 | Mar 3, 2022 |
|
2066 | Increased AngII | Increase plasma Ang II | Mar 17, 2020 | Mar 17, 2020 | |
2298 | Increased AngII | Impaired gustatory nerve | Mar 28, 2021 | Mar 28, 2021 | |
2300 | Increased AngII | Increased proinflammatory mediators | Mar 28, 2021 | Mar 28, 2021 | |
2327 | Increased AngII | Increased Ang II type 1 receptor (AT1R) | Apr 10, 2021 | Apr 10, 2021 |
|
2317 | Increased AngII | Sodium inhibition, Sweet enhancement | Apr 10, 2021 | Apr 10, 2021 |
|
2069 | Chronic ROS | Porcupine-induced Wnt secretion and Wnt signaling activation | Mar 23, 2020 | May 13, 2021 |
|
2070 | Porcupine-induced Wnt secretion and Wnt signaling activation | beta-catenin activation | Mar 23, 2020 | Nov 9, 2021 |
|
3199 | beta-catenin activation | EMT | Apr 23, 2024 | Apr 23, 2024 |
|
2076 | Decreased, 11KT | Impaired, Spermatogenesis | Apr 16, 2020 | Apr 19, 2021 |
|
2165 | Decreased, 11KT | Decrease, Fertility | Jul 21, 2020 | Jul 21, 2020 | |
2166 | Decreased, 11KT | Decreased spermatogenesis | Jul 21, 2020 | Jul 21, 2020 |
|
2164 | Impaired, Spermatogenesis | Decrease, Fertility | Jul 13, 2020 | Jul 13, 2020 | |
2274 | Impaired, Spermatogenesis | impaired, Fertility | Jan 29, 2021 | Aug 15, 2022 |
|
2937 | Impaired, Spermatogenesis | Decreased, Viable Offspring | Jun 2, 2023 | Sep 29, 2023 |
|
2692 | Impaired, Spermatogenesis | Viable offspring, decreased | Jul 18, 2022 | Jul 18, 2022 | |
2078 | Increase, Cripto-1 expression | Inhibition, Activin signaling | Apr 21, 2020 | Jul 7, 2020 |
|
2082 | Increase, Cripto-1 expression | Inhibition, Fin regeneration | Apr 21, 2020 | Jul 10, 2020 |
|
2079 | Inhibition, Activin signaling | Inhibition, Fin regeneration | Apr 21, 2020 | Jul 10, 2020 |
|
2080 | Inhibition, Fin regeneration | Reduced, Swimming performance | Apr 21, 2020 | Jul 10, 2020 |
|
2084 | cell injury | Increase, Regenerative cell proliferation (urothelial cells) | Apr 21, 2020 | Apr 21, 2020 |
|
3097 | Increase, Formation of DNA photoproducts | Increase, DSB | Nov 16, 2023 | Nov 16, 2023 | |
3361 | Increase, Protein oxidation | Cell injury/death | Oct 8, 2024 | Oct 8, 2024 |
|
2223 | Increase, Protein oxidation | Increase, Cell death | Dec 4, 2020 | Dec 4, 2020 | |
2090 | Increase, Protein oxidation | Increase, Abnormal osmoregulation | Apr 30, 2020 | Apr 30, 2020 |
|
2091 | Increase, Abnormal osmoregulation | Increase, Body fluid overload | Apr 30, 2020 | Apr 30, 2020 |
|
3290 | Increase, Abnormal osmoregulation | Increased, Blood viscosity | Jul 8, 2024 | Dec 3, 2024 | |
2181 | Increase, Abnormal osmoregulation | Increase, Tissue/organ damage | Nov 2, 2020 | Nov 2, 2020 | |
2092 | Increase, Body fluid overload | Increase, Mortality | Apr 30, 2020 | Apr 30, 2020 |
|
2094 | Decrease, MMP | Decrease, OXPHOS | Apr 30, 2020 | Apr 30, 2020 |
|
2347 | Decrease, MMP | Increase, Programmed cell death | Apr 11, 2021 | Apr 11, 2021 | |
3163 | Decrease, MMP | Mitochondrial dysfunction | Mar 14, 2024 | Mar 14, 2024 |
|
2096 | Decrease, ATP pool | Increase, Mortality | Apr 30, 2020 | Apr 30, 2020 |
|
2121 | Decrease, ATP pool | Increase, Necrosis | May 8, 2020 | May 8, 2020 | |
2120 | Decrease, ATP pool | Increase, Oocyte apoptosis | May 8, 2020 | May 8, 2020 | |
2786 | Decrease, ATP pool | Decreased Na/K ATPase activity | Oct 19, 2022 | Oct 19, 2022 |
|
2768 | Decrease, ATP pool | Cell injury/death | Sep 27, 2022 | Sep 27, 2022 |
|
2179 | Decrease, ATP pool | Decrease, ATPase activity | Nov 2, 2020 | Nov 2, 2020 | |
2204 | Decrease, ATP pool | Decrease, Cell proliferation | Nov 12, 2020 | Dec 7, 2020 |
|
2209 | Decrease, ATP pool | Decrease, Oogenesis | Nov 25, 2020 | Nov 25, 2020 | |
2214 | Decrease, ATP pool | Increase, Cell death | Dec 4, 2020 | Dec 4, 2020 |
|
2216 | Decrease, ATP pool | Increase, Fatty acid β-oxidation | Dec 4, 2020 | Dec 4, 2020 | |
2098 | Decrease, TAG | Decrease, ATP pool | Apr 30, 2020 | Apr 30, 2020 |
|
2110 | Decrease, Global DNA methylation | Decrease, Heritable DNA methylation (F3) | Apr 30, 2020 | Apr 30, 2020 |
|
2102 | Decrease, Global DNA methylation | Increase, Casp transcription | Apr 30, 2020 | Apr 30, 2020 |
|
2105 | Increase, Casp transcription | Increase, Ovarian somatic cell apoptosis | Apr 30, 2020 | Apr 30, 2020 |
|
2103 | Increase, Casp transcription | Increase, Oocyte apoptosis | Apr 30, 2020 | Apr 30, 2020 |
|
2104 | Increase, Oocyte apoptosis | Decrease, Oogenesis | Apr 30, 2020 | Apr 30, 2020 |
|
2386 | Increase, Oocyte apoptosis | impaired, Fertility | May 12, 2021 | May 12, 2021 |
|
2400 | Increase, Oocyte apoptosis | Decrease of egg production and cummulative fecundity | May 18, 2021 | May 18, 2021 |
|
2106 | Increase, Ovarian somatic cell apoptosis | Increase, Ovarian follicle breakdown | Apr 30, 2020 | Apr 30, 2020 |
|
2107 | Increase, Ovarian follicle breakdown | Decrease, Oogenesis | Apr 30, 2020 | Apr 30, 2020 |
|
2560 | Increase, Ovarian follicle breakdown | Decrease, Fecundity | Feb 4, 2022 | Feb 4, 2022 | |
2111 | Decrease, Heritable DNA methylation (F3) | Increase, Casp transcription (F3) | Apr 30, 2020 | Apr 30, 2020 |
|
2116 | Increase, Casp transcription (F3) | Increase, Ovarian somatic cell apoptosis (F3) | Apr 30, 2020 | Apr 30, 2020 |
|
2112 | Increase, Casp transcription (F3) | Increase, Oocyte apoptosis (F3) | Apr 30, 2020 | Apr 30, 2020 |
|
2113 | Increase, Oocyte apoptosis (F3) | Decrease, Oogenesis (F3) | Apr 30, 2020 | Apr 30, 2020 |
|
2115 | Decrease, Fecundity (F3) | Decrease, Population growth rate | Apr 30, 2020 | Apr 30, 2020 |
|
2114 | Decrease, Oogenesis (F3) | Decrease, Fecundity (F3) | Apr 30, 2020 | Apr 30, 2020 |
|
2117 | Increase, Ovarian somatic cell apoptosis (F3) | Increase, Ovarian follicle breakdown (F3) | Apr 30, 2020 | Apr 30, 2020 |
|
2118 | Increase, Ovarian follicle breakdown (F3) | Decrease, Oogenesis (F3) | Apr 30, 2020 | Apr 30, 2020 |
|
2119 | Increase, Mitochondrial ATP synthase antagonism | Decrease, OXPHOS | May 8, 2020 | May 8, 2020 | |
2229 | Increase, Mitochondrial ATP synthase antagonism | Decrease, ATP pool | Dec 4, 2020 | Dec 4, 2020 |
|
2137 | Downregulation of ACE2 | Increased AngII | May 15, 2020 | May 15, 2020 |
|
2136 | Downregulation of ACE2 | Increase plasma Ang II | May 15, 2020 | May 15, 2020 | |
2517 | Downregulation of ACE2 | Ang (1-7) levels reduced | Oct 28, 2021 | Oct 28, 2021 | |
2141 | Status epilepticus | Overactivation, NMDARs | May 21, 2020 | May 21, 2020 | |
2783 | Status epilepticus | Increased, Intracellular Calcium overload | Oct 12, 2022 | Jul 24, 2023 |
|
2782 | Status epilepticus | Increased, glutamate | Oct 12, 2022 | Sep 3, 2023 |
|
2145 | Reduction, E2 Synthesis by the undifferentiated gonad | Increased, Differentiation to Testis | Jun 15, 2020 | Jul 11, 2022 |
|
2146 | Increased, Differentiation to Testis | Increased, Male Biased Sex Ratio | Jun 15, 2020 | Jan 3, 2023 |
|
2147 | Increased, Male Biased Sex Ratio | Decrease, Population growth rate | Jun 15, 2020 | Jan 3, 2023 |
|
2148 | TLR4 activation | Activation, JNK | Jul 9, 2020 | Jul 9, 2020 |
|
2155 | TLR4 activation | Activation, TGF-beta pathway | Jul 9, 2020 | Jul 9, 2020 | |
2251 | TLR4 activation | AP-1 activation | Dec 23, 2020 | Dec 23, 2020 | |
2157 | AP-1 activation | TGFbeta expression | Jul 9, 2020 | Jul 9, 2020 |
|
2151 | Pin-1 activation | TGFbeta expression | Jul 9, 2020 | Jul 9, 2020 |
|
2152 | TGFbeta expression | Activation, TGF-beta pathway | Jul 9, 2020 | Jul 9, 2020 |
|
2158 | 11β-hydroxylase inhibition | Decreased, 11KT | Jul 13, 2020 | Jul 13, 2020 | |
2275 | 11β-hydroxylase inhibition | Cortisol and 11β-(OH) testosterone decreased | Feb 9, 2021 | Feb 9, 2021 |
|
2161 | Decreased spermatogenesis | impaired, Fertility | Jul 13, 2020 | Jul 13, 2020 |
|
2388 | Decreased spermatogenesis | Decrease of egg production and cummulative fecundity | May 12, 2021 | May 12, 2021 |
|
2620 | Decreased spermatogenesis | Decrease, Fecundity | Mar 28, 2022 | Mar 28, 2022 |
|
2623 | Decreased spermatogenesis | Decrease, Reproduction | Mar 28, 2022 | Mar 28, 2022 |
|
2624 | Decreased spermatogenesis | Decrease, Population growth rate | Mar 28, 2022 | Mar 28, 2022 |
|
2162 | Inhibition of 11β-HSD | Decreased, 11KT | Jul 13, 2020 | Jul 13, 2020 |
|
3142 | Reduced granulosa cell proliferation | irregularities, ovarian cycle | Mar 7, 2024 | Jun 23, 2024 |
|
2170 | Inhibition, Chitinase | Decrease, Digestion of old cuticle | Oct 21, 2020 | Oct 21, 2020 |
|
2172 | Inhibition, Chitobiase | Decrease, Digestion of old cuticle | Oct 21, 2020 | Oct 21, 2020 |
|
2176 | Decrease, ATP synthase activity | Decrease, ATP pool | Nov 2, 2020 | Nov 2, 2020 | |
2344 | Decrease, ATP synthase activity | Decrease, Leaf development | Apr 11, 2021 | Apr 11, 2021 | |
2178 | Increase, Tissue/organ damage | Decrease, Growth | Nov 2, 2020 | Nov 2, 2020 | |
2180 | Decrease, ATPase activity | Increase, Abnormal osmoregulation | Nov 2, 2020 | Nov 2, 2020 | |
2183 | Increase, Complex III dysfunction | Increase, Cyt c release | Nov 2, 2020 | Nov 2, 2020 | |
2186 | Increase, Complex III dysfunction | Increase, ROS | Nov 2, 2020 | Nov 2, 2020 | |
2184 | Increase, Cyt c release | Increase, Apoptosis | Nov 2, 2020 | Nov 2, 2020 | |
3050 | Increase, Cyt c release | Caspase activation | Sep 14, 2023 | Sep 14, 2023 |
|
2189 | Increase, Complex I dysfunction | Increase, ROS | Nov 2, 2020 | Nov 2, 2020 | |
2192 | Reactive Metabolite | Mitochondrial dysfunction EMPTY | Nov 2, 2020 | Nov 2, 2020 | |
2194 | Reactive Metabolite | Immune cell activation | Nov 2, 2020 | Nov 2, 2020 |
|
3151 | Reactive Metabolite | Mitochondrial dysfunction | Mar 13, 2024 | Mar 13, 2024 |
|
2200 | ER stress | Apoptotic cell death | Nov 2, 2020 | Nov 2, 2020 |
|
2643 | ER stress | Increase, Apoptosis | Apr 8, 2022 | Apr 8, 2022 |
|
2932 | Mitochondrial dysfunction EMPTY | Impaired insulin signaling | May 25, 2023 | May 25, 2023 | |
3043 | Mitochondrial dysfunction EMPTY |