This Event is licensed under the Creative Commons BY-SA license. This license allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. If you remix, adapt, or build upon the material, you must license the modified material under identical terms.
Event: 1016
Key Event Title
Inhibition, Feeding
Short name
Biological Context
Level of Biological Organization |
---|
Individual |
Key Event Components
Process | Object | Action |
---|---|---|
feeding behavior | decreased |
Key Event Overview
AOPs Including This Key Event
AOP Name | Role of event in AOP | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|
GluCl activation leading to mortality | KeyEvent | Knut Erik Tollefsen (send email) | Under development: Not open for comment. Do not cite | |
iGABAR activation leading to mortality | KeyEvent | Knut Erik Tollefsen (send email) | Under development: Not open for comment. Do not cite | |
elavl3, sox10, mbp induced neuronal effects | AdverseOutcome | Donggon Yoo (send email) | Under development: Not open for comment. Do not cite | |
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding | AdverseOutcome | John Frisch (send email) | Under development: Not open for comment. Do not cite |
Taxonomic Applicability
Term | Scientific Term | Evidence | Link |
---|---|---|---|
Animals | Metazoa | High | NCBI |
Life Stages
Life stage | Evidence |
---|---|
All life stages | Moderate |
Sex Applicability
Term | Evidence |
---|---|
Unspecific | High |
Key Event Description
Inhibition of feeding is caused by appetite suppression from brain signals, a reduced ability to capture prey, increased lethargy, and reduction in locomotion activity (McDonald 2017).
How It Is Measured or Detected
Inhibition of feeding is measured in the short-term by decreased consumption of available food by weight of food ingested, and for extended periods by decreased weight gain or weight loss.
Domain of Applicability
Life Stage: All life stages.
Sex: Applies to both males and females.
Taxonomic: Animals.
Regulatory Significance of the Adverse Outcome
References
McDonald, M.D. 2017. An AOP analysis of selective serotonin reuptake inhibitors (SSRIs) for fish. Comparative Biochemistry and Physiology, Part C-Toxicology and Pharmacology 197: 19–31.
NOTE: Italics indicate edits from John Frisch January 2025.