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Aop: 160

AOP Title

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Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality

Short name:

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iGABAR activation leading to mortality

Graphical Representation

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Click to download graphical representation template

Authors

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You Song1, Knut Erik Tollefsen1,2

1Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalléen 21, N-0349 Oslo, Norway

2Norwegian University of Life Sciences (NMBU), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV). P.O. Box 5003, N-1432 Ås, Norway

Contact: knut.erik.tollefsen@niva.no

Point of Contact

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Knut Erik Tollefsen   (email point of contact)

Contributors

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  • Knut Erik Tollefsen

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Increased, Mortality May 15, 2017 11:34
Activation, ionotropic GABA Receptor chloride channel September 16, 2017 10:16
Increased, Inhibitory postsynaptic potential September 16, 2017 10:16
Induction, Somatic muscle paralysis September 16, 2017 10:16
Increased, Chloride conductance September 16, 2017 10:16
Increased, Neuronal synaptic inhibition September 16, 2017 10:16
Inhibition, Feeding December 03, 2016 16:37
Induction, Somatic muscle paralysis leads to Increased, Mortality December 03, 2016 16:38
Activation, ionotropic GABA Receptor chloride channel leads to Increased, Chloride conductance December 03, 2016 16:38
Increased, Chloride conductance leads to Increased, Neuronal synaptic inhibition December 03, 2016 16:38
Increased, Neuronal synaptic inhibition leads to Increased, Inhibitory postsynaptic potential December 03, 2016 16:38
Increased, Inhibitory postsynaptic potential leads to Induction, Somatic muscle paralysis December 03, 2016 16:38
Induction, Somatic muscle paralysis leads to Inhibition, Feeding December 03, 2016 16:38
Inhibition, Feeding leads to Increased, Mortality December 03, 2016 16:38
Emamectin benzoate November 29, 2016 18:42

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 762 Activation, ionotropic GABA Receptor chloride channel Activation, ionotropic GABA Receptor chloride channel
2 KE 1012 Increased, Inhibitory postsynaptic potential Increased, Inhibitory postsynaptic potential
3 KE 1014 Induction, Somatic muscle paralysis Induction, Somatic muscle paralysis
4 KE 761 Increased, Chloride conductance Increased, Chloride conductance
5 KE 1015 Increased, Neuronal synaptic inhibition Increased, Neuronal synaptic inhibition
6 KE 1016 Inhibition, Feeding Inhibition, Feeding
7 AO 351 Increased, Mortality Increased, Mortality

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Induction, Somatic muscle paralysis leads to Increased, Mortality adjacent
Activation, ionotropic GABA Receptor chloride channel leads to Increased, Chloride conductance adjacent
Increased, Chloride conductance leads to Increased, Neuronal synaptic inhibition adjacent
Increased, Neuronal synaptic inhibition leads to Increased, Inhibitory postsynaptic potential adjacent
Increased, Inhibitory postsynaptic potential leads to Induction, Somatic muscle paralysis adjacent
Induction, Somatic muscle paralysis leads to Inhibition, Feeding adjacent
Inhibition, Feeding leads to Increased, Mortality adjacent

Network View

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Stressors

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Name Evidence Term
Emamectin benzoate

Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Daphnia magna Daphnia magna NCBI

Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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