Key Event Components

Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
A complete list of all KECs is available in TSV format on the Downloads Page.

Showing 1 to 25 of 1139 KECs

ID	Action	Process	Object	Associated Key Events (KEs)


1	increased	cell proliferation (GO:0008283)		3 Events 57: Proliferation, Cell proliferation in the absence of cytotoxicity 416: Increase proliferation, Leydig cell 1182: Increase, Cell Proliferation (Epithelial Cells)
2	increased	hyperplasia (MESH:D006965)		3 Events 142: Hyperplasia, Hyperplasia 415: Hyperplasia, Leydig cell 1192: Increased, Ductal Hyperplasia
3	increased	hepatocellular carcinoma (MESH:D006528)		334: Promotion, Hepatocelluar carcinoma
4	decreased	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	NADH-ubiquinone oxidoreductase chain 1 (PR:000031316)	888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
5	decreased	NADH dehydrogenase (ubiquinone) activity (GO:0008137)	NADH-ubiquinone oxidoreductase chain 1 (PR:000031316)	887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)
6	functional change		mitochondrion (GO:0005739)	2 Events 177: Increase, Mitochondrial dysfunction 2363: Elevated mitochondrial ROS and dysfunction
7	abnormal	Proteostasis deficiencies (MESH:D057165)	protein (CHEBI:36080)	889: Proteostasis, impaired
8	pathological	brain inflammation (MP:0001847)	microglial cell (CL:0000129)	188: Neuroinflammation
9	pathological	brain inflammation (MP:0001847)	astrocyte (CL:0000127)	188: Neuroinflammation
10	increased	loss of dopaminergic neurons (MP:0003244)		890: Degeneration of dopaminergic neurons of the nigrostriatal pathway
11	occurrence		Parkinsonian disorders (MESH:D020734)	896: Parkinsonian motor deficits
12	increased	ecdysone receptor-mediated signaling pathway (GO:0035076)	ecdysone receptor holocomplex (GO:0008230)	103: Increase, Ecdysone receptor hyperactivation
13	decreased	ecdysis-triggering hormone activity (GO:0008255)		988: Decrease, Circulating ecdysis triggering hormone
14	increased	chitin biosynthetic process (GO:0006031)	chitin (CHEBI:17029)	990: Increase, Incomplete ecdysis
15	increased	muscle contraction (GO:0006936)		2 Events 993: Decrease, Abdominal muscle contraction 601: Overactivation, muscle contraction
16	increased	mortality (MESH:D009026)		4 Events 351: Increased Mortality 350: Increase, Mortality 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction 947: Increase, Early Life Stage Mortality
17	increased	gene expression (GO:0010467)	Eip75B protein, Drosophila (MESH:C061375)	1264: Increase, Nuclear receptor E75b gene expression
18	increased	gene expression (GO:0010467)	nuclear hormone receptor FTZ-F1 (fruit fly) (PR:P33244)	1265: Decrease, Fushi tarazu factor-1 gene expression
19	decreased	peptide secretion (GO:0002790)	cardioactive peptide (fruit fly) (PR:Q9VCW0)	1266: Decrease, Circulating crustacean cardioactive peptide
20	decreased	transmission of nerve impulse (GO:0019226)	motor neuron (CL:0000100)	1267: Decrease, Ecdysis motor program activity
21	decreased	excitatory postsynaptic potential (GO:0060079)		1268: Decrease, Excitatory postsynaptic potential
22	increased	receptor antagonist activity (GO:0048019)	peroxisome proliferator-activated receptor alpha (PR:000013056)	998: Binding of antagonist, PPAR alpha
23	increased	transcription corepressor activity (GO:0003714)	nuclear receptor corepressor 2 (PR:000011048)	1000: stabilization, PPAR alpha co-repressor
24	increased	transcription corepressor activity (GO:0003714)	nuclear receptor corepressor 1 (PR:000011047)	1000: stabilization, PPAR alpha co-repressor
25	decreased	receptor transactivation (GO:0035624)	peroxisome proliferator-activated receptor alpha (PR:000013056)	858: Decreased, PPARalpha transactivation of gene expression