Key Event Title
|Level of Biological Organization|
Key Event Components
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP|
|AChE inhibition - acute mortality||AdverseOutcome|
|sodium channel modulation||AdverseOutcome|
|GluCl activation to mortality||AdverseOutcome|
|iGABAR activation leading to mortality||AdverseOutcome|
|GluCl activation leading to mortality||AdverseOutcome|
|Cox1 inhibition renal failure||AdverseOutcome|
|unknown MIE renal failure||AdverseOutcome|
|EcR agonism leading to mortality||AdverseOutcome|
|AhR mediated mortality||AdverseOutcome|
|All life stages||High|
Key Event Description
Increased mortality refers to an increase in the number of individuals dying in an experimental replicate group or in a population over a specific period of time.
How It Is Measured or Detected
Mortality is typically measured by observation. Lack of any heart beat, gill movement, and body movement are typical signs of death used in the evaluation of mortality of animals.
Domain of Applicability
All living things are susceptible to mortality.
Evidence for Perturbation by Stressor
Regulatory Significance of the Adverse Outcome
Increased mortality is one of the most common regulatory assessment endpoints, along with reduced growth and reduced reproduction.