API

Event: 351

Key Event Title

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Increased, Mortality

Short name

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Increased, Mortality

Biological Context

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Level of Biological Organization
Population



Key Event Components

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Process Object Action
mortality increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
AChE inhibition - acute mortality AdverseOutcome
sodium channel modulation AdverseOutcome
chemical-induced arrthymias AdverseOutcome
GluCl activation to mortality AdverseOutcome
iGABAR activation leading to mortality AdverseOutcome
GluCl activation leading to mortality AdverseOutcome
OAT1 inhibition AdverseOutcome
Cox1 inhibition renal failure AdverseOutcome
unknown MIE renal failure AdverseOutcome

Stressors

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Taxonomic Applicability

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Term Scientific Term Evidence Link
zebrafish Danio rerio High NCBI
Gallus gallus Gallus gallus High NCBI

Life Stages

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Life stage Evidence
All life stages High

Sex Applicability

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Term Evidence
Unspecific High

Key Event Description

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Increased mortality refers to an increase in the number of individuals dying in an experimental replicate group or in a population over a specific period of time.


How It Is Measured or Detected

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Mortality is typically measured by observation. Lack of any heart beat, gill movement, and body movement are typical signs of death used in the evaluation of mortality of animals.


Domain of Applicability

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All living things are susceptible to mortality.


Regulatory Significance of the Adverse Outcome

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Increased mortality is one of the most common regulatory assessment endpoints, along with reduced growth and reduced reproduction.


References

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