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Event: 351

Key Event Title

A descriptive phrase which defines a discrete biological change that can be measured. More help

Increased Mortality

Short name
The KE short name should be a reasonable abbreviation of the KE title and is used in labelling this object throughout the AOP-Wiki. More help
Increased Mortality
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Biological Context

Structured terms, selected from a drop-down menu, are used to identify the level of biological organization for each KE. More help
Level of Biological Organization
Population

Key Event Components

The KE, as defined by a set structured ontology terms consisting of a biological process, object, and action with each term originating from one of 14 biological ontologies (Ives, et al., 2017; https://aopwiki.org/info_pages/2/info_linked_pages/7#List). Biological process describes dynamics of the underlying biological system (e.g., receptor signalling).Biological process describes dynamics of the underlying biological system (e.g., receptor signaling).  The biological object is the subject of the perturbation (e.g., a specific biological receptor that is activated or inhibited). Action represents the direction of perturbation of this system (generally increased or decreased; e.g., ‘decreased’ in the case of a receptor that is inhibited to indicate a decrease in the signaling by that receptor).  Note that when editing Event Components, clicking an existing Event Component from the Suggestions menu will autopopulate these fields, along with their source ID and description.  To clear any fields before submitting the event component, use the 'Clear process,' 'Clear object,' or 'Clear action' buttons.  If a desired term does not exist, a new term request may be made via Term Requests.  Event components may not be edited; to edit an event component, remove the existing event component and create a new one using the terms that you wish to add.  Further information on Event Components and Biological Context may be viewed on the attached pdf. More help
Process Object Action
mortality increased

Key Event Overview

AOPs Including This Key Event

All of the AOPs that are linked to this KE will automatically be listed in this subsection. This table can be particularly useful for derivation of AOP networks including the KE. Clicking on the name of the AOP will bring you to the individual page for that AOP. More help
AOP Name Role of event in AOP Point of Contact Author Status OECD Status
AChE inhibition - acute mortality AdverseOutcome Dan Villeneuve (send email) Under Development: Contributions and Comments Welcome Under Development
sodium channel modulation AdverseOutcome Kellie Fay (send email) Under Development: Contributions and Comments Welcome
chemical-induced arrthymias AdverseOutcome Kevin Dreher (send email) Under Development: Contributions and Comments Welcome
GluCl activation to mortality AdverseOutcome Helen Poynton (send email) Under Development: Contributions and Comments Welcome
iGABAR activation leading to mortality AdverseOutcome Knut Erik Tollefsen (send email) Under development: Not open for comment. Do not cite
GluCl activation leading to mortality AdverseOutcome Knut Erik Tollefsen (send email) Under development: Not open for comment. Do not cite
OAT1 inhibition AdverseOutcome Kellie Fay (send email) Under Development: Contributions and Comments Welcome
Cox1 inhibition renal failure AdverseOutcome Kellie Fay (send email) Under Development: Contributions and Comments Welcome
unknown MIE renal failure AdverseOutcome Kellie Fay (send email) Under Development: Contributions and Comments Welcome
AChE inhibition - acute mortality via predation AdverseOutcome Kristie Sullivan (send email) Under development: Not open for comment. Do not cite
SARS-CoV-2 leads to acute respiratory distress AdverseOutcome Young Jun Kim (send email) Open for comment. Do not cite Under Development
DIO2i posterior swim bladder AdverseOutcome Dries Knapen (send email) Under Development: Contributions and Comments Welcome EAGMST Approved
DIO2i anterior swim bladder AdverseOutcome Dries Knapen (send email) Under Development: Contributions and Comments Welcome EAGMST Approved
DIO1i posterior swim bladder AdverseOutcome Dries Knapen (send email) Under Development: Contributions and Comments Welcome EAGMST Approved
DIO1i anterior swim bladder AdverseOutcome Dries Knapen (send email) Under Development: Contributions and Comments Welcome EAGMST Approved
TPOi anterior swim bladder AdverseOutcome Dries Knapen (send email) Under Development: Contributions and Comments Welcome EAGMST Approved
TPOi retinal layer structure AdverseOutcome Lucia Vergauwen (send email) Open for citation & comment EAGMST Under Review
TLR9 activation leading to Multi Organ Failure and ARDS AdverseOutcome Gillina Bezemer (send email) Under development: Not open for comment. Do not cite
TPOi eye size AdverseOutcome Lucia Vergauwen (send email) Under development: Not open for comment. Do not cite Under Development
TPOi photoreceptor patterning AdverseOutcome Lucia Vergauwen (send email) Under development: Not open for comment. Do not cite Under Development
Inhibition of Fyna leading to increased mortality AdverseOutcome Vid Modic (send email) Open for citation & comment
Oxidation of Reduced Glutathione Leading to Mortality AdverseOutcome Zarin Hossain (send email) Open for citation & comment
GSK3beta inactivation leads to increased mortality AdverseOutcome Vid Modic (send email) Open for citation & comment
Organo-Phosphate Chemicals leading to sensory axonal peripheral neuropathy and mortality AdverseOutcome SAROJ AMAR (send email) Under development: Not open for comment. Do not cite

Taxonomic Applicability

Latin or common names of a species or broader taxonomic grouping (e.g., class, order, family) that help to define the biological applicability domain of the KE.In many cases, individual species identified in these structured fields will be those for which the strongest evidence used in constructing the AOP was available in relation to this KE. More help
Term Scientific Term Evidence Link
all species all species High NCBI

Life Stages

An indication of the the relevant life stage(s) for this KE. More help
Life stage Evidence
All life stages High

Sex Applicability

An indication of the the relevant sex for this KE. More help
Term Evidence
Unspecific Moderate

Key Event Description

A description of the biological state being observed or measured, the biological compartment in which it is measured, and its general role in the biology should be provided. More help

Increased mortality refers to an increase in the number of individuals dying in an experimental replicate group or in a population over a specific period of time.

How It Is Measured or Detected

A description of the type(s) of measurements that can be employed to evaluate the KE and the relative level of scientific confidence in those measurements.These can range from citation of specific validated test guidelines, citation of specific methods published in the peer reviewed literature, or outlines of a general protocol or approach (e.g., a protein may be measured by ELISA). Do not provide detailed protocols. More help

Mortality of animals is generally observed as cessation of the heart beat, breathing (gill or lung movement) and locomotory movements. Mortality is typically measured by observation. Depending on the size of the organism, instruments such as microscopes may be used. The reported metric is mostly the mortality rate: the number of deaths in a given area or period, or from a particular cause.

Depending on the species and the study setup, mortality can be measured:

  • in the lab by recording mortality during exposure experiments
  • in dedicated setups simulating a realistic situation such as mesocosms or drainable ponds for aquatic species
  • in the field, for example by determining age structure after one capture, or by capture-mark-recapture efforts. The latter is a method commonly used in ecology to estimate an animal population's size where it is impractical to count every individual.

Domain of Applicability

A description of the scientific basis for the indicated domains of applicability and the WoE calls (if provided).  More help

All living things are susceptible to mortality.

Regulatory Significance of the Adverse Outcome

An AO is a specialised KE that represents the end (an adverse outcome of regulatory significance) of an AOP. More help

Increased mortality is one of the most common regulatory assessment endpoints, along with reduced growth and reduced reproduction.

References

List of the literature that was cited for this KE description. More help