API XML

Aop: 104

AOP Title

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Altered ion channel activity leading impaired heart function

Short name:

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chemical-induced arrthymias

Graphical Representation

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Click to download graphical representation template

Authors

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Kevin Dreher, US EPA

Point of Contact

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Kevin Dreher   (email point of contact)

Contributors

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  • Kevin Dreher

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
impaired, ion channels December 03, 2016 16:37
Increased, Mortality May 15, 2017 11:34
Altered, Action Potential September 16, 2017 10:15
Increased, cardiac arrthymia September 16, 2017 10:15
impaired, ion channels leads to Altered, Action Potential December 03, 2016 16:37
Altered, Action Potential leads to Increased, cardiac arrthymia December 03, 2016 16:37
Increased, cardiac arrthymia leads to Increased, Mortality December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 697 impaired, ion channels impaired, ion channels
2 KE 698 Altered, Action Potential Altered, Action Potential
3 KE 699 Increased, cardiac arrthymia Increased, cardiac arrthymia
4 AO 351 Increased, Mortality Increased, Mortality

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
impaired, ion channels leads to Altered, Action Potential adjacent
Altered, Action Potential leads to Increased, cardiac arrthymia adjacent
Increased, cardiac arrthymia leads to Increased, Mortality adjacent

Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
All life stages

Taxonomic Applicability

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Sex Applicability

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Sex Evidence
Unspecific

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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