API

Aop: 104

AOP Title

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Altered ion channel activity leading impaired heart function

Short name:

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chemical-induced arrthymias

Authors

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Kevin Dreher, US EPA

Point of Contact

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Kevin Dreher

Contributors

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  • Kevin Dreher

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
impaired, ion channels December 03, 2016 16:37
Increased, Mortality May 15, 2017 11:34
Altered, Action Potential September 16, 2017 10:15
Increased, cardiac arrthymia September 16, 2017 10:15
impaired, ion channels leads to Altered, Action Potential December 03, 2016 16:37
Altered, Action Potential leads to Increased, cardiac arrthymia December 03, 2016 16:37
Increased, cardiac arrthymia leads to Increased, Mortality December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
impaired, ion channels impaired, ion channels

Key Events

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Title Short name
Altered, Action Potential Altered, Action Potential
Increased, cardiac arrthymia Increased, cardiac arrthymia

Adverse Outcome

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Title Short name
Increased, Mortality Increased, Mortality

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
All life stages

Taxonomic Applicability

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Sex Applicability

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Sex Evidence
Unspecific

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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