|
98 |
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
|
Ksenia Groh |
Under development: Not open for comment. Do not cite |
Under Development |
5-HTT |
increased predation |
|
1.29 |
|
97 |
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
5-HTT |
increased predation |
|
1.29 |
|
195 |
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
203 |
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
204 |
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
82 |
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
unk |
colony loss/failure |
|
1.29 |
|
16 |
Acetylcholinesterase inhibition leading to acute mortality
|
Dan Villeneuve |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
AChE |
acute mortality |
Under Development |
1.3 |
|
210 |
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
|
Jinhee Choi |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
46 |
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
|
Ted Simon |
Open for citation & comment |
Included in OECD Work Plan |
AFB1 |
hepatocellular carcinoma |
EAGMST Under Review |
1.8 |
|
57 |
AhR activation leading to hepatic steatosis
|
Michelle Angrish |
Under development: Not open for comment. Do not cite |
Under Development |
AhR |
hepatic steatosis |
|
1.29 |
|
151 |
AhR signalling leading to placental vascular disruption
|
Sabrina Tait |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.42 |
|
62 |
AKT2 activation leading to hepatic steatosis
|
Michelle Angrish |
Under development: Not open for comment. Do not cite |
Under Development |
AKT2 |
hepatic steatosis |
|
1.29 |
|
15 |
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
|
Carole Yauk |
Open for citation & comment |
Included in OECD Work Plan |
DNA alkylation |
heritable mutations |
TFHA/WNT Endorsed |
1.11 |
|
139 |
Alkylation of DNA leading to cancer 1
|
Carole Yauk |
Under development: Not open for comment. Do not cite |
Under Development |
DNA alkylation |
cancer |
|
|
|
126 |
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
|
Tammy Stoker |
Under development: Not open for comment. Do not cite |
Under Development |
alpha Norad Receptors |
delayed ovulation |
|
1.29 |
|
105 |
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
Alpha2u |
adenomas and carcinomas |
|
1.29 |
|
104 |
Altered ion channel activity leading impaired heart function
|
Kevin Dreher |
Under development: Not open for comment. Do not cite |
Under Development |
multiple |
impaired heart function |
|
1.29 |
|
117 |
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
AR |
adenomas and carcinomas |
Under Development |
1.26 |
|
23 |
Androgen receptor agonism leading to reproductive dysfunction
|
Dan Villeneuve |
Open for citation & comment |
Included in OECD Work Plan |
AR |
reproductive dysfunction |
EAGMST Approved |
1.12 |
|
19 |
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
|
Mukesh Patel |
Under development: Not open for comment. Do not cite |
Under Development |
AR |
adverse effects in the male foetus |
|
|
|
6 |
Antagonist binding to PPARα leading to body-weight loss
|
Kurt A. Gust |
Open for comment. Do not cite |
Included in OECD Work Plan |
PPAR |
starvation-like body-weight loss |
EAGMST Under Review |
2.3 |
|
170 |
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
187 |
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
|
Barnett Rattner |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.31 |
|
165 |
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
205 |
AOP from chemical insult to cell death
|
Mathieu Vinken |
Open for comment. Do not cite |
Under Development |
|
|
|
|
|
7 |
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
|
Elise Grignard |
Open for citation & comment |
Included in OECD Work Plan |
PPAR |
impaired fertility |
EAGMST Under Review |
1.21 |
|
153 |
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
|
Tammy Stoker |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
25 |
Aromatase inhibition leading to reproductive dysfunction
|
Dan Villeneuve |
Open for citation & comment |
Included in OECD Work Plan |
Aromatate Inhib |
reproductive dysfunction |
TFHA/WNT Endorsed |
1.12 |
|
21 |
aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
|
Markus Hecker |
Open for comment. Do not cite |
Included in OECD Work Plan |
AhR |
embryo toxicity |
EAGMST Under Review |
1.27 |
|
150 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
|
Amani Farhat |
Open for comment. Do not cite |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.7 |
|
131 |
Aryl hydrocarbon receptor activation leading to uroporphyria
|
Amani Farhat |
Open for comment. Do not cite |
Included in OECD Work Plan |
AhR |
uroporphyria |
EAGMST Under Review |
1.7 |
|
96 |
Axonal sodium channel modulation leading to acute mortality
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
sodium channel |
acute mortality |
|
1.29 |
|
164 |
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
48 |
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
|
Anna Price |
Open for citation & comment |
Included in OECD Work Plan |
Glutamate Receptor |
learning and memory impairment. |
TFHA/WNT Endorsed |
1.23 |
|
17 |
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins during brain development leads to impairment of learning and memory
|
Florianne Tschudi-Monnet |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
multiple |
neuroinflammation leading to neurodegeneration |
Under Development |
1.13 |
|
10 |
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
|
Ping Gong |
Open for comment. Do not cite |
Included in OECD Work Plan |
GABA |
epileptic seizures |
EAGMST Under Review |
1.15 |
|
26 |
Calcium-mediated neuronal ROS production and energy imbalance
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
unclear |
energy imbalance |
|
|
|
106 |
Chemical binding to tubulin in oocytes leading to aneuploid offspring
|
Francesco Marchetti |
Under development: Not open for comment. Do not cite |
Under Development |
tubulin? |
aneuploid offspring |
|
|
|
27 |
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
|
Mathieu Vinken |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
ABCB11 |
cholestatic liver injury |
Under Development |
1.19 |
|
13 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
|
Anna Price |
Open for citation & comment |
Included in OECD Work Plan |
NMDAR |
impairment of learning and memory abilities |
TFHA/WNT Endorsed |
1.22 |
|
12 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
|
Florianne Tschudi-Monnet |
Open for citation & comment |
Included in OECD Work Plan |
NMDAR |
neuroinflammation and lead to neurodegeneration |
EAGMST Approved |
1.13 |
|
220 |
Chronic Cyp2E1 Activation Leading to Liver Cancer
|
Carole Yauk |
Open for citation & comment |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.24 |
|
118 |
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
cytotox is not MIE |
hepatocellular adenomas and carcinomas |
|
1.29 |
|
171 |
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
107 |
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
|
Richard C. Peffer, Ph.D., DABT |
Open for citation & comment |
Included in OECD Work Plan |
CAR |
hepatocellular adenomas and carcinomas |
EAGMST Under Review |
1.18 |
|
40 |
Covalent Protein binding leading to Skin Sensitisation
|
Brigitte Landesmann |
Open for citation & comment |
Included in OECD Work Plan |
|
|
TFHA/WNT Endorsed |
1.1 |
|
177 |
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
28 |
Cyclooxygenase inhibition leading reproductive failure
|
Dan Villeneuve |
Under development: Not open for comment. Do not cite |
Under Development |
cyclooxygenase |
reproductive failure |
|
1.29 |
|
63 |
Cyclooxygenase inhibition leading to reproductive dysfunction
|
Dalma Martinovic-Weigelt |
Under development: Not open for comment. Do not cite |
Under Development |
cyclooxygenase |
reproductive dysfunction |
|
1.29 |
|
100 |
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
|
Dalma Martinovic-Weigelt |
Under development: Not open for comment. Do not cite |
Under Development |
cyclooxygenase |
reproductive dysfunction |
|
1.29 |
|
101 |
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
|
Dalma Martinovic-Weigelt |
Under development: Not open for comment. Do not cite |
Under Development |
cyclooxygenase |
reproductive dysfunction |
|
1.29 |
|
102 |
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
|
Dalma Martinovic-Weigelt |
Under development: Not open for comment. Do not cite |
Under Development |
cyclooxygenase |
reproductive dysfunction |
|
1.29 |
|
103 |
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
|
Dalma Martinovic-Weigelt |
Under development: Not open for comment. Do not cite |
Under Development |
cyclooxygenase |
reproductive dysfunction |
|
1.29 |
|
260 |
CYP2E1 activation and formation of protein adducts leading to neurodegeneration
|
Jelle Broeders |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
|
109 |
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
cytotox is not MIE |
bronchioloalveolar adenomas and carcinomas |
|
1.29 |
|
116 |
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
cytotox is not MIE |
renal tubular adenomas and carcinomas |
|
1.29 |
|
86 |
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
glucose oxidase |
colony loss/failure |
|
1.29 |
|
111 |
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
AR |
leydig cell tumors |
|
1.29 |
|
158 |
Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation
|
Dries Knapen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.35 |
|
157 |
Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation
|
Dries Knapen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.35 |
|
156 |
Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation
|
Dries Knapen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.35 |
|
155 |
Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation
|
Dries Knapen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.35 |
|
43 |
Disruption of VEGFR Signaling Leading to Developmental Defects
|
Tom Knudsen |
Open for citation & comment |
Included in OECD Work Plan |
VEGF |
developmental outcomes |
EAGMST Under Review |
1.6 |
|
240 |
DNA Adducts Leading to Liver Hemangiosarcoma
|
Annie Jarabek |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
193 |
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
|
Jonathan Haselman |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
167 |
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
4 |
Ecdysone receptor agonism leading to mortality
|
Knut Erik Tollefsen |
Open for citation & comment |
Under Development |
EcR |
mortality |
|
|
|
148 |
EGFR Activation Leading to Decreased Lung Function
|
Karsta Luettich |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
EGFR |
|
Under Development |
1.51 |
|
162 |
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
72 |
Epigenetic modification of PPARG leading to adipogenesis
|
Michelle Angrish |
Under development: Not open for comment. Do not cite |
Under Development |
PPARg |
adipogenesis |
|
1.29 |
|
115 |
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
cytotox not MIE |
forestomach tumors |
|
1.29 |
|
53 |
ER agonism leading to reduced survival due to renal failure
|
Tom Hutchinson |
Under development: Not open for comment. Do not cite |
Under Development |
ER |
reduced survival |
|
1.29 |
|
52 |
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males
|
Tom Hutchinson |
Under development: Not open for comment. Do not cite |
Under Development |
ER |
altered sexual differentiation |
|
1.29 |
|
199 |
ER mediated breast cancer AOP
|
Molly M Morgan |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
146 |
Estrogen Receptor Activation and Female Precocious Puberty
|
Jeff Welch |
Under development: Not open for comment. Do not cite |
Under Development |
ER |
|
|
1.29 |
|
200 |
Estrogen receptor activation leading to breast cancer
|
Molly M Morgan |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
29 |
Estrogen receptor agonism leading to reproductive dysfunction
|
Tom Hutchinson |
Under development: Not open for comment. Do not cite |
Under Development |
ER |
reproductive dysfunction |
|
1.29 |
|
30 |
Estrogen receptor antagonism leading to reproductive dysfunction
|
Dan Villeneuve |
Open for citation & comment |
Included in OECD Work Plan |
ER |
reproductive dysfunction |
EAGMST Under Review |
1.12 |
|
95 |
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
ERG |
reduced survival |
|
1.29 |
|
216 |
Excessive reactive oxygen species production leading to reproductive dysfunction
|
Knut Erik Tollefsen |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
238 |
Excessive reactive oxygen species production leading to reproductive failure
|
Knut Erik Tollefsen |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
|
217 |
Gastric ulcer formation
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
64 |
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
|
Susan Laws |
Under development: Not open for comment. Do not cite |
Under Development |
GR |
decreased male fertitlity |
|
1.29 |
|
14 |
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
GR |
increased disease susceptibility |
|
1.29 |
|
113 |
Glutamate-gated chloride channel activation leading to acute mortality
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
GluCl Channel |
acute mortality |
|
1.29 |
|
161 |
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
|
Knut Erik Tollefsen |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
168 |
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
169 |
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
211 |
Handbook development AOP
|
Dan Villeneuve |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
229 |
Helicobacter pylori to gastric ulcer
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
194 |
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
|
Jonathan Haselman |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
99 |
Histamine (H2) receptor antagonism leading to reduced survival
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
H2 |
reduced survival |
|
1.29 |
|
212 |
Histone deacetylase inhibition leading to testicular toxicity
|
Takashi Yamada |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.52 |
|
124 |
HMG-CoA reductase inhibition leading to decreased fertility
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
HMG-CoA reductase |
decreased fertility |
|
1.29 |
|
59 |
HNF4alpha suppression leading to hepatic steatosis
|
Michelle Angrish |
Under development: Not open for comment. Do not cite |
Under Development |
HNF4alpha |
hepatic steatosis |
|
1.29 |
|
114 |
HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
HPPD |
corneal papillomas and carcinomas |
|
1.29 |
|
202 |
In-utero DNA topoisomerase II poisons leading to infant leukaemia
|
Andrea Terron |
Open for comment. Do not cite |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.53 |
|
112 |
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
dopamine?? |
endometrial adenocarcinomas |
|
1.29 |
|
81 |
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
metabolic stress is not MIE |
colony loss/failure |
|
1.29 |
|
173 |
Increased substance interaction with the resident cell membrane components leading to lung fibrosis
|
Sabina Halappanavar |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.32 |
|
120 |
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
5α-reductase |
leydig cell tumors |
|
1.29 |
|
154 |
Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
|
Kiyoshi Kushima |
Open for comment. Do not cite |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.38 |
|
218 |
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
|
Florence Pagé-Larivière |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
219 |
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
|
Florence Pagé-Larivière |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
213 |
Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
32 |
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
|
Michelle Embry |
Under development: Not open for comment. Do not cite |
Under Development |
nitric oxide |
liver tumors |
|
|
|
110 |
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
NIS |
follicular cell adenomas and carcinomas |
|
1.29 |
|
242 |
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
|
Stefan Scholz |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
|
256 |
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
|
Angela Mally |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
|
54 |
Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
|
Anna Price |
Open for comment. Do not cite |
Included in OECD Work Plan |
NIS |
learning and memory deficits in children |
EAGMST Under Review |
1.28 |
|
108 |
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
pyruvate dehydrogenase |
hepatocellular carcinoma |
|
1.29 |
|
3 |
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
|
Andrea Terron |
Open for citation & comment |
Included in OECD Work Plan |
NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor |
Motor function, impaired |
EAGMST Approved |
1.33 |
|
119 |
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
TPO |
follicular cell adenomas and carcinomas |
|
1.29 |
|
42 |
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
|
Kevin Crofton |
Open for citation & comment |
Included in OECD Work Plan |
TPO |
neurodevelopmental outcomes |
EAGMST Under Review |
1.10 |
|
152 |
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
|
Erik Janus |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.41 |
|
136 |
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
|
Justin Teeguarden |
Open for citation & comment |
Included in OECD Work Plan |
unclear |
contact nasal tumors |
EAGMST Under Review |
2.7 |
|
188 |
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
|
Jonathan Haselman |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
160 |
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
|
Knut Erik Tollefsen |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
208 |
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
|
Jinhee Choi |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
201 |
Juvenile hormone receptor agonism leading to male offspring induction associated population decline
|
Knut Erik Tollefsen |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
128 |
Kidney dysfunction by decreased thyroid hormone
|
Seokjoo Yoon |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
unclear - KE as MIE? |
kidnney dysfunction |
Under Development |
1.40 |
|
33 |
Kidney toxicity induced by activation of 5HT2C
|
Kevin Crofton |
Under development: Not open for comment. Do not cite |
Under Development |
5-HTT2c |
kidney toxicity |
|
|
|
241 |
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
|
Marvin Martens |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
|
34 |
LXR activation leading to hepatic steatosis
|
Marina Goumenou |
Under development: Not open for comment. Do not cite |
Under Development |
LXR |
liver steatosis |
|
|
|
144 |
Lysosomal damage leading to liver inflammation
|
Brigitte Landesmann |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
Liver, Inflammation |
Under Development |
1.47 |
|
222 |
Mental stress to agitation
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
221 |
Mental stress to depression
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
66 |
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
|
Gary Klinefelter |
Under development: Not open for comment. Do not cite |
Under Development |
GR |
modulation of leydig cell function |
|
1.29 |
|
68 |
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
|
Gary Klinefelter |
Under development: Not open for comment. Do not cite |
Under Development |
proteins - undefined |
modulation of leydig cell function |
|
1.29 |
|
69 |
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
|
Gary Klinefelter |
Under development: Not open for comment. Do not cite |
Under Development |
multiple |
modulation of leydig cell function |
|
1.29 |
|
67 |
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
|
Gary Klinefelter |
Under development: Not open for comment. Do not cite |
Under Development |
estradiol |
modulation of leydig cell function |
|
1.29 |
|
71 |
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
|
Gary Klinefelter |
Under development: Not open for comment. Do not cite |
Under Development |
GR |
modulation of leydig cell function |
|
1.29 |
|
74 |
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
|
Gary Klinefelter |
Under development: Not open for comment. Do not cite |
Under Development |
unk |
modulation of leydig cell function |
|
1.29 |
|
70 |
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
|
Gary Klinefelter |
Under development: Not open for comment. Do not cite |
Under Development |
|
modulation of leydig cell function |
|
1.29 |
|
215 |
Molecular events lead to epilepsy
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
234 |
Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
|
Timothy Allen |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
233 |
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
|
Timothy Allen |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
207 |
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
|
Jinhee Choi |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
35 |
Narcosis leading to respiratory failure
|
Dries Knapen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
undefined |
sensitisation of the respiratory tract |
Under Development |
1.2 |
|
214 |
Network of SSRIs (selective serotonin reuptake inhibitors)
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
232 |
NFE2/Nrf2 repression to steatosis
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
61 |
NFE2L2/FXR activation leading to hepatic steatosis
|
Michelle Angrish |
Under development: Not open for comment. Do not cite |
Under Development |
multiple |
hepatic steatosis |
|
1.29 |
|
77 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
|
87 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
|
88 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
|
78 |
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
|
90 |
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
|
80 |
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
|
79 |
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
|
178 |
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
89 |
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
|
184 |
Nosema infection causes abnormal role change that leads to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
183 |
Nosema infection increases energetic demands leading to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
60 |
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
|
Michelle Angrish |
Under development: Not open for comment. Do not cite |
Under Development |
PXR |
hepatic steatosis |
|
1.29 |
|
58 |
NR1I3 (CAR) suppression leading to hepatic steatosis
|
Michelle Angrish |
Under development: Not open for comment. Do not cite |
Under Development |
CAR |
hepatic steatosis |
|
1.29 |
|
227 |
NSAID induced PTGS1 inactivation to gastric ulcer
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
228 |
NSAID induced PTGS2 inactivation to gastric ulcer
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
138 |
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
p-amino hippuric acid |
renal failure and mortality |
|
1.29 |
|
31 |
Oxidation of iron in hemoglobin leading to hematotoxicity
|
Mitchell S. Wilbanks |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
heme oxidation ? |
hematotoxicity |
Under Development |
1.16 |
|
239 |
Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling
|
Annie Jarabek |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
192 |
Pendrin inhibition leading to altered amphibian metamorphosis
|
Jonathan Haselman |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
149 |
Peptide Oxidation Leading to Hypertension
|
Frazer Lowe |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.50 |
|
11 |
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol
|
Jun Kanno |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
case study |
Under Development |
2.5 |
|
36 |
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
|
Michelle Angrish |
Under development: Not open for comment. Do not cite |
Under Development |
b-oxidation fatty acid |
steatosis |
|
1.29 |
|
206 |
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
|
Jinhee Choi |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.54 |
|
209 |
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
|
Jinhee Choi |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
130 |
Phospholipase A inhibitors lead to hepatotoxicity
|
Seokjoo Yoon |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
phospolipase A |
hepatotoxicity |
Under Development |
1.39 |
|
166 |
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
37 |
PPARalpha-dependent liver cancer
|
Chris Corton |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
PPAR alpha |
liver cancer |
Under Development |
1.17 |
|
163 |
PPARgamma activation leading to sarcomas in rats, mice, and hamsters
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
18 |
PPARα activation in utero leading to impaired fertility in males
|
Elise Grignard |
Open for citation & comment |
Included in OECD Work Plan |
PPAR |
impaired fertility |
EAGMST Under Review |
1.21 |
|
51 |
PPARα activation leading to impaired fertility in adult male rodents
|
Elise Grignard |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
PPAR α |
impaired fertility |
Under Development |
1.21 |
|
230 |
presynaptic neuron 1 activation to epilepsy
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
231 |
presynaptic neuron 2 repression to epilepsy
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
122 |
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
|
Dalma Martinovic-Weigelt |
Under development: Not open for comment. Do not cite |
Under Development |
Prolyl hydroxylase |
reproductive dysfunction |
|
1.29 |
|
38 |
Protein Alkylation leading to Liver Fibrosis
|
Brigitte Landesmann |
Open for citation & comment |
Included in OECD Work Plan |
Protein alkylation |
liver fibrosis |
TFHA/WNT Endorsed |
1.14 |
|
185 |
Queen egg-laying decrease leads to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
257 |
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
|
Angela Mally |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
|
258 |
Renal protein alkylation leading to kidney toxicity
|
Angela Mally |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
|
237 |
Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression
|
Sarah Søs Poulsen |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
|
39 |
Sensitisation of the Respiratory Tract induced by Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins
|
Kristie Sullivan |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
unclear what proteins |
sensitisation of the respiratory tract |
Under Development |
1.20 |
|
259 |
Sensitization induction of the intestinal tract by food proteins
|
Erwin Roggen |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
|
236 |
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
|
Timothy Allen |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
235 |
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
|
Timothy Allen |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
225 |
Serotonin transporter activation to agitation
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
224 |
Serotonin transporter activation to depression
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
223 |
Serotonin transporter activation to seizure
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
197 |
Sodium channel (Nav1.1) inhibition leading to population decline
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
94 |
Sodium channel inhibition leading to congenital malformations
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
sodium channel |
congenital malformations |
|
1.29 |
|
93 |
sodium channel inhibition leading to increased predation
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
sodium channel |
increased predation |
|
1.29 |
|
91 |
Sodium channel inhibition leading to reduced survival
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
sodium channel |
reduced survival |
|
1.29 |
|
134 |
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
|
Mary Gilbert |
Under development: Not open for comment. Do not cite |
Under Development |
NIS |
neurodevelopmental outcomes |
|
1.29 |
|
176 |
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
|
Jonathan Haselman |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
226 |
SSRI (Selective serotonin reuptake inhibitor) to hypertension
|
Lyle Burgoon |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
85 |
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
unclear |
colony loss/failure |
|
1.29 |
|
84 |
Suppression of immune system contributes to impaired development and leads to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
unclear |
colony loss/failure |
|
1.29 |
|
41 |
Sustained AhR Activation leading to Rodent Liver Tumours
|
Rick Becker |
Open for citation & comment |
Included in OECD Work Plan |
AhR |
liver tumors |
EAGMST Under Review |
1.7 |
|
175 |
Thyroperoxidase inhibition leading to altered amphibian metamorphosis
|
Jonathan Haselman |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
159 |
Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation
|
Dries Knapen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.35 |
|
189 |
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
|
Jonathan Haselman |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
190 |
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
|
Jonathan Haselman |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
191 |
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
|
Jonathan Haselman |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
245 |
Uncoupling of photophosphorylation leading to reduced ATP production associated growth inhibition
|
Knut Erik Tollefsen |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
|
186 |
unknown MIE leading to renal failure and mortality
|
Kellie Fay |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
123 |
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
|
Dalma Martinovic-Weigelt |
Under development: Not open for comment. Do not cite |
Under Development |
Unknown |
reproductive dysfunction |
|
1.29 |
|
8 |
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
|
Katie Paul Friedman |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
mulitple |
neurodevelopmental outcomes |
Under Development |
1.9 |
|
121 |
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
|
Charles Wood |
Under development: Not open for comment. Do not cite |
Under Development |
unclear |
urothelial papillomas and carcinomas |
|
1.29 |
|
180 |
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
179 |
Varroa mite infestation increases virus levels leading to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
196 |
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
|
Jeanelle Martinez |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
|
182 |
Weather event contributes abnormal foraging leading to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
181 |
Weather event contributes to colony loss/failure
|
Carlie LaLone |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
1.29 |
|
73 |
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
|
Tammy Stoker |
Under development: Not open for comment. Do not cite |
Under Development |
DBH |
reduced fecundity |
|
1.29 |