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Showing 1 to 25 of 574 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 896: Parkinsonian motor deficits WPHA/WNT Endorsed 1.33
4 Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 Knut Erik Tollefsen BY-SA 103: Increase, Ecdysone receptor hyperactivation
6 Antagonist binding to PPARα leading to body-weight loss Kurt A. Gust BY-SA 998: Binding of antagonist, PPAR alpha 864: Decreased, Body Weight WPHA/WNT Endorsed 2.3
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard BY-SA 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Under Review 1.21
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Open for adoption 239: Activation, Pregnane-X receptor, NR1l2 319: Loss, Cochlear function Under Development 1.9
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Ping Gong BY-SA 667: Binding at picrotoxin site, iGABAR chloride channel 613: Occurrence, Epileptic seizure WPHA/WNT Endorsed 1.15
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno BY-SA 245: Activation, PXR/SXR None Under Development 2.5
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet BY-SA 201: Binding of antagonist, NMDA receptors WPHA/WNT Endorsed 1.13
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price BY-SA 201: Binding of antagonist, NMDA receptors 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.22
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone BY-SA 122: Increase, Glucocorticoid receptor activation 323: Increased, Disease susceptibility
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk BY-SA 97: Alkylation, DNA 336: Increase, Heritable mutations in offspring WPHA/WNT Endorsed 1.11
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve BY-SA 12: Acetylcholinesterase (AchE) Inhibition Under Development 1.3
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich BY-SA 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.13
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard BY-SA 227: Activation, PPARα Under Review 1.21
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel Open for adoption 26: Antagonism, Androgen receptor 337: N/A, Impairment of reproductive capacity
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker BY-SA 18: Activation, AhR None WPHA/WNT Endorsed 1.27
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve BY-SA 25: Agonism, Androgen receptor 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
25 Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve BY-SA 36: Inhibition, Aromatase 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
26 Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon Open for adoption 51: Inhibition, Ca++ ATPase 1392: Increase, Oxidative Stress
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken BY-SA 41: Inhibition, Bile Salt Export Pump (ABCB11) 357: Cholestasis, Pathology Under Development 1.19
28 Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve BY-SA 79: Inhibition, Cyclooxygenase activity 253: N/A, Reproductive failure
29 Estrogen receptor agonism leading to reproductive dysfunction Undefined BY-SA 111: Agonism, Estrogen receptor
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve BY-SA 112: Antagonism, Estrogen receptor 360: Decrease, Population growth rate Under Review 1.12
31 Oxidation of iron in hemoglobin leading to hematotoxicity Undefined Open for adoption 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) 321: N/A, Cyanosis occurs Under Development 1.16
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Undefined BY-SA None None