443 |
DNA damage and mutations leading to Metastatic Breast Cancer |
Usha Adiga |
BY-SA |
- Increased, DNA damage and mutation
|
| Under Development |
1.103 |
450 |
Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality |
SAROJ AMAR |
BY-SA |
- Acetylcholinesterase (AchE) Inhibition
|
- Sensory axonal peripheral neuropathy
- Increased Mortality
| |
|
544 |
Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation |
Travis Karschnik |
All rights reserved |
- Neuropathy target esterase, inhibited
|
- Delayed neuropathy, increased
| |
|
543 |
Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration |
Travis Karschnik |
All rights reserved |
- Neuropathy target esterase, inhibited
|
- Delayed neuropathy, increased
| |
|
202 |
Inhibitor binding to topoisomerase II leading to infant leukaemia |
Andrea Terron |
BY-SA |
- Binding to (interferes with) topoisomerase II enzyme
|
| WPHA/WNT Endorsed |
1.53 |
389 |
Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis |
Knut Erik Tollefsen |
BY-SA |
- Increase, Oxygen-evolving complex damage
|
- Decrease, Reproduction
- Decrease, Population growth rate
| |
|
423 |
Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway |
Fei Li |
BY-SA |
- Activation, PARP1
- ROS formation
|
| |
|
98 |
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation |
Ksenia Groh |
BY-SA |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
| |
1.29 |
97 |
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline |
Kellie Fay |
BY-SA |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
- Increase, predation
- Decrease, Population growth rate
| |
1.29 |
195 |
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase |
Kellie Fay |
BY-SA |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
| |
1.29 |
203 |
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline |
Kellie Fay |
BY-SA |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
- Decreased, Reproductive Success
- Decrease, Population growth rate
| |
1.29 |
204 |
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase |
Kellie Fay |
BY-SA |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
- Increased, Reproductive Success
- Increased, Population
| |
1.29 |
305 |
5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
BY-SA |
|
- anogenital distance (AGD), decreased
| Under Development |
1.90 |
429 |
A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants |
Erwin L Roggen |
BY-SA |
|
| |
|
82 |
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
|
- impaired, Larval development
- Death/Failure, Colony
| |
1.29 |
427 |
ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. |
Evangelos-Panagiotis Daskalopoulos |
BY-SA |
|
| |
|
16 |
Acetylcholinesterase inhibition leading to acute mortality |
Dan Villeneuve |
BY-SA |
- Acetylcholinesterase (AchE) Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| Under Development |
1.3 |
312 |
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement |
Kristie Sullivan |
BY-SA |
- Acetylcholinesterase (AchE) Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| |
|
281 |
Acetylcholinesterase Inhibition Leading to Neurodegeneration |
Karen Watanabe |
BY-SA |
- Acetylcholinesterase (AchE) Inhibition
|
| |
|
210 |
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building |
Jinhee Choi |
All rights reserved |
|
| |
|
499 |
Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release |
Travis Karschnik |
All rights reserved |
- Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
|
- Impairment, Learning and memory
| |
|
500 |
Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis |
Travis Karschnik |
All rights reserved |
- Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
|
- Impairment, Learning and memory
| |
|
462 |
Activation of reactive oxygen species leading the atherosclerosis |
Hiromi Ohara |
BY-SA |
- Increase, Reactive Oxygen Species
|
| |
|
439 |
Activation of the AhR leading to metastatic breast cancer |
Louise Benoit |
BY-SA |
|
| Under Development |
1.105 |
503 |
Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation |
Barbara Viviani |
BY-SA |
- Activation, estrogen receptor alpha
|
- Uterine adenocarcinoma (endometrioid adenocarcinoma Type I)
| Under Review |
1.100 |
545 |
Activation, Pregnane-X receptor, NR1l2 leads to Increased, plasma low-density lipoprotein (LDL) cholesterol |
John Frisch |
BY-SA |
- Activation, Pregnane-X receptor, NR1l2
|
- Increased, plasma low-density lipoprotein (LDL) cholesterol
| |
|
538 |
Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways |
Yanhong Wei |
All rights reserved |
|
- Increase, Vascular disrupting effects
| |
|
452 |
Adverse outcome pathway of PM-induced respiratory toxicity |
li qing |
BY-SA |
- Non-coding RNA expression profile alteration
|
- Chronic obstructive pulmonary disease
| |
|
282 |
Adverse outcome pathway on photochemical toxicity initiated by light exposure |
Satomi Onoue |
BY-SA |
- ROS generation from photoactivated chemicals
|
- Inflamatory events in light-exposed tissues
| Under Review |
1.49 |
476 |
Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity |
Yue Zhang |
All rights reserved |
- Increased, Reactive oxygen species
- Disruption, Estrogen receptor
- Antagonism, Androgen receptor
|
- Decreased sperm quantity or quality in the adult, Decreased fertility
- anogenital distance (AGD), decreased
- Malformation, cryptorchidism - maldescended testis
- Decrease, Reproduction
| |
|
46 |
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) |
Ted Simon |
BY-SA |
- Formation, Pro-mutagenic DNA Adducts
|
- Tumorigenesis, Hepatocellular carcinoma
| Under Review |
1.8 |
458 |
AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Prakash Patel |
Open for adoption |
|
- Cognitive function, decreased
| |
|
459 |
AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Prakash Patel |
Open for adoption |
|
- Cognitive function, decreased
| |
|
57 |
AhR activation leading to hepatic steatosis |
Michelle Angrish |
BY-SA |
|
- Increased, Liver Steatosis
| |
1.29 |
494 |
AhR activation leading to liver fibrosis |
Xavier COUMOUL |
All rights reserved |
|
| |
|
151 |
AhR activation leading to preeclampsia |
Sabrina Tait |
All rights reserved |
|
| Under Development |
1.42 |
62 |
AKT2 activation leading to hepatic steatosis |
Michelle Angrish |
BY-SA |
- systemic inflammation leading to hepatic steatosis
|
- Increased, Liver Steatosis
| |
1.29 |
465 |
Alcohol dehydrogenase leading to reproductive dysfunction |
Donggon Yoo |
BY-SA |
- Increase, Alcohol dehydrogenase
|
| |
|
15 |
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations |
Carole Yauk |
BY-SA |
|
- Increase, Heritable mutations in offspring
| WPHA/WNT Endorsed |
1.11 |
139 |
Alkylation of DNA leading to cancer 1 |
Carole Yauk |
Open for adoption |
|
| |
|
322 |
Alkylation of DNA leading to reduced sperm count |
Carole Yauk |
BY-SA |
|
| |
|
126 |
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation |
Undefined |
BY-SA |
- Inhibition, Antgonism of NE receptor
|
- Decreased, Decreased fecundity
| |
1.29 |
105 |
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) |
Charles Wood |
BY-SA |
- Increased, Binding of chemicals to 2u (serum)
|
- Increase, Adenomas/carcinomas (renal tubular)
| |
1.29 |
104 |
Altered ion channel activity leading impaired heart function |
Undefined |
BY-SA |
|
| |
1.29 |
515 |
An overview of adverse outcome pathway linked between PM2.5 exposure and congenital heart defects |
Liang Chen |
All rights reserved |
|
| |
|
345 |
Androgen receptor (AR) antagonism leading to decreased fertility in females |
Terje Svingen |
BY-SA |
- Antagonism, Androgen receptor
|
- irregularities, ovarian cycle
- impaired, Fertility
| Under Development |
1.109 |
477 |
Androgen receptor (AR) antagonism leading to hypospadias in male offspring |
Terje Svingen |
BY-SA |
- Antagonism, Androgen receptor
|
| |
|
344 |
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring |
Terje Svingen |
BY-SA |
- Antagonism, Androgen receptor
|
- Nipple retention (NR), increased
| Under Development |
1.108 |
306 |
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
BY-SA |
- Antagonism, Androgen receptor
|
- anogenital distance (AGD), decreased
| Under Development |
1.90 |
117 |
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
Open for adoption |
- Activation, Androgen receptor
|
- Increase, hepatocellular adenomas and carcinomas
| Under Development |
1.26 |
495 |
Androgen receptor activation leading to prostate cancer |
Jianxiang Li |
All rights reserved |
- Activation, Androgen receptor
|
| |
|
547 |
Androgen receptor agonism leading to long anogenital distance in female offspring |
Johanna Zilliacus |
All rights reserved |
- Agonism, Androgen receptor
|
| |
|
376 |
Androgen receptor agonism leading to male-biased sex ratio |
Dan Villeneuve |
BY-SA |
- Agonism, Androgen receptor
|
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.12 |
496 |
Androgen receptor agonism leading to reproduction dysfunction (in zebrafish) |
Hongling Liu |
BY-SA |
- Agonism, Androgen receptor
- Increased, gene expression of AR
|
- Decreased, Population trajectory
| |
|
23 |
Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) |
Dan Villeneuve |
BY-SA |
- Agonism, Androgen receptor
|
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.12 |
19 |
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) |
Mukesh Patel |
Open for adoption |
- N/A, Androgen receptor, Antagonism
|
- N/A, Impairment of reproductive capacity
| |
|
372 |
Androgen receptor antagonism leading to testicular cancer |
Chander K. Negi |
BY-SA |
- Antagonism, Androgen receptor
|
| |
|
382 |
Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis |
Young Jun Kim |
BY-SA |
- Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
|
| Under Development |
1.96 |
460 |
Antagonism of Smoothened receptor leading to orofacial clefting |
Jacob Reynolds |
All rights reserved |
- Antagonism, Smoothened receptor
|
| Under Development |
1.101 |
6 |
Antagonist binding to PPARα leading to body-weight loss |
Kurt A. Gust |
BY-SA |
- Binding of antagonist, PPAR alpha
|
| WPHA/WNT Endorsed |
2.3 |
170 |
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat |
Charles Wood |
BY-SA |
|
- Increased, Adenomas/carcinomas (mammary)
| |
1.29 |
187 |
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage |
Undefined |
BY-SA |
- Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
- Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
- Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
|
- Impaired recruitment , Population trajectory
| Under Development |
1.31 |
165 |
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse |
Charles Wood |
BY-SA |
|
- Promotion, ovarian adenomas
- Promotion, ovarian granular cell tumors
| |
1.29 |
393 |
AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation |
Fei Li |
BY-SA |
- Increased, Hepatic thyroid hormone uptake/transport
|
| |
|
335 |
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment |
Nathalia Pereira Souza |
BY-SA |
- Mitochondrial dysfunction
|
| |
|
205 |
AOP from chemical insult to cell death |
Mathieu Vinken |
BY-SA |
- Decompartmentalization
- Direct mitochondrial inhibition
- narcosis
|
| |
|
481 |
AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. |
Hailin Xu |
BY-SA |
- Increase, Reactive oxygen species formation
|
- Increased incidence of respiratory disease
- Dysfunction of respiratory system
| |
|
7 |
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female |
Elise Grignard |
BY-SA |
- reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
|
- impaired, Fertility
- irregularities, ovarian cycle
| Under Review |
1.21 |
153 |
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats |
Undefined |
BY-SA |
- Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
|
- Decreased fertility, Reduced number of oocytes ovulated
| |
1.29 |
25 |
Aromatase inhibition leading to reproductive dysfunction |
Dan Villeneuve |
BY-SA |
|
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.12 |
346 |
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation |
Kelvin Santana Rodriguez |
BY-SA |
|
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.12 |
456 |
Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity |
Prarthana Shankar |
BY-SA |
|
- Increase, Early Life Stage Mortality
| Under Review |
|
455 |
Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development |
Prarthana Shankar |
BY-SA |
|
- Increase, Early Life Stage Mortality
- Facial cartilage structures are reduced in size and morphologically distorted
| Under Review |
|
21 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 |
Markus Hecker |
BY-SA |
|
| WPHA/WNT Endorsed |
1.27 |
150 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF |
Amani Farhat |
BY-SA |
|
- Increase, Early Life Stage Mortality
| WPHA/WNT Endorsed |
1.7 |
418 |
Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway |
Dianke Yu |
All rights reserved |
|
| |
|
419 |
Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway |
Dianke Yu |
All rights reserved |
|
| |
|
417 |
Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway |
Dianke Yu |
All rights reserved |
|
| |
|
416 |
Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway |
Dianke Yu |
All rights reserved |
|
| |
|
420 |
Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway |
Dianke Yu |
All rights reserved |
|
| |
|
415 |
Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway |
Dianke Yu |
All rights reserved |
|
| |
|
414 |
Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway |
Dianke Yu |
All rights reserved |
|
| |
|
131 |
Aryl hydrocarbon receptor activation leading to uroporphyria |
Amani Farhat |
BY-SA |
|
| WPHA/WNT Endorsed |
1.7 |
96 |
Axonal sodium channel modulation leading to acute mortality |
Kellie Fay |
BY-SA |
- modulation, sodium channel
|
| |
1.29 |
164 |
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse |
Charles Wood |
BY-SA |
- Activation, beta-2 adrenergic receptor
|
- Promotion, mesovarian leiomyomas
| |
1.29 |
535 |
Binding and activation of GPER leading to learning and memory impairments |
Zedong Ouyang |
All rights reserved |
- protein-coupled estrogen receptor 1 (GPER) activation
|
- Impairment, Learning and memory
| |
|
48 |
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. |
Anna Price |
BY-SA |
- Binding of agonist, Ionotropic glutamate receptors
|
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.23 |
475 |
Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons |
Shihori Tanabe |
All rights reserved |
- Binding of agonist, Ionotropic glutamate receptors
|
- Impairment, Learning and memory
| Under Development |
1.107 |
17 |
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory |
Marie-Gabrielle Zurich |
BY-SA |
- Binding, Thiol/seleno-proteins involved in protection against oxidative stress
|
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.13 |
284 |
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease |
Frederic Y. Bois |
BY-SA |
- Binding, Thiol/seleno-proteins involved in protection against oxidative stress
|
| |
|
506 |
Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation |
Jessica Resnick |
All rights reserved |
- Influenza A Virus (IAV) binds sialic acid glycan receptor
|
- Influenza A Virus (IAV) shedding and transmission
| |
|
428 |
Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis |
Laure-Alix Clerbaux |
BY-SA |
|
| Under Development |
1.96 |
374 |
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis |
Anna Price |
All rights reserved |
|
| Under Development |
1.96 |
395 |
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) |
Magda Sachana |
BY-SA |
|
- Cerebrovascular disease (stroke)
| Under Development |
1.96 |
422 |
Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption |
Laure-Alix Clerbaux |
BY-SA |
|
| Under Development |
1.96 |
468 |
Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) |
Laure-Alix Clerbaux |
BY-SA |
|
| |
|
430 |
Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation |
Sally Mayasich |
All rights reserved |
|
- Viral infection and host-to-host transmission, proliferated
| Under Development |
1.96 |
320 |
Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality |
Young Jun Kim |
BY-SA |
|
| Under Development |
1.96 |
381 |
Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia |
Young Jun Kim |
BY-SA |
|
| Under Development |
1.96 |
319 |
Binding to ACE2 leading to lung fibrosis |
Young Jun Kim |
BY-SA |
- Induced dysregulation of ACE2
|
| Under Development |
1.96 |
379 |
Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation |
Shihori Tanabe |
All rights reserved |
|
- Thrombosis and Disseminated Intravascular Coagulation
| Under Development |
1.96 |
314 |
Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) |
Yasuharu Otsubo |
BY-SA |
- Binding to estrogen receptor (ER)-α in immune cells
|
- Exacerbation of systemic lupus erythematosus (SLE)
| Under Development |
1.73 |
486 |
Binding to the extracellular protein laminin leading to decreased cognitive function |
Eliska Kuchovska |
BY-SA |
- Binding, extracellular matrix protein laminin
|
- Cognitive function, decreased
| |
|
10 |
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain |
Ping Gong |
BY-SA |
- Binding at picrotoxin site, iGABAR chloride channel
|
- Occurrence, Epileptic seizure
| WPHA/WNT Endorsed |
1.15 |
442 |
Binding to voltage gate sodium channels during development leads to cognitive impairment |
Iris Mangas |
BY-SA |
- Binding to voltage-gated sodium channel
|
- Cognitive function, decreased
| Under Review |
1.91 |
484 |
Bisphenol A analogs induce cellular dysfunction in human trophoblast cells in a thyroid hormone receptor-dependent manner: in silico and in vitro analyses |
Xiaoyun Wu |
BY-SA |
|
| |
|
397 |
Bulky DNA adducts leading to mutations |
Carole Yauk |
BY-SA |
- Bulky DNA adducts, increase
|
| Under Development |
1.11 |
464 |
Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits |
Julia Meerman |
All rights reserved |
- Activation of metabotropic glutamate receptor
- Inositol triphosphate receptor activation
- Overactivation, NMDARs
- Inhibition GABAA receptor
- Opening, voltage-gated calcium channels
|
- Parkinsonian motor deficits
| |
|
26 |
Calcium-mediated neuronal ROS production and energy imbalance |
Lyle Burgoon |
Open for adoption |
|
| |
|
519 |
Cardiac ion channels blockade leading to arrhythmia associated sudden cardiac death |
Young Jun Kim |
Open for adoption |
|
| |
|
449 |
Ceramide synthase inhibition leading to neural tube defects |
Lola Bajard |
BY-SA |
- Inhibition of Ceramide Synthase
|
| |
|
106 |
Chemical binding to tubulin in oocytes leading to aneuploid offspring |
Francesco Marchetti |
BY-SA |
|
- Increase, Aneuploid offspring
| Under Review |
1.11 |
360 |
Chitin synthase 1 inhibition leading to mortality |
Simon Schmid |
BY-SA |
- Inhibition, Chitin synthase 1
|
| WPHA/WNT Endorsed |
1.94 |
358 |
Chitinase inhibition leading to mortality |
Simon Schmid |
All rights reserved |
|
| Under Development |
1.94 |
359 |
Chitobiase inhibition leading to mortality |
Simon Schmid |
All rights reserved |
|
| Under Development |
1.94 |
27 |
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) |
Mathieu Vinken |
BY-SA |
- Inhibition, Bile Salt Export Pump (ABCB11)
|
| Under Development |
1.19 |
13 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities |
Anna Price |
BY-SA |
- Binding of antagonist, NMDA receptors
|
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.22 |
12 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging |
Florianne Tschudi-Monnet |
BY-SA |
- Binding of antagonist, NMDA receptors
|
- N/A, Neurodegeneration
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.13 |
118 |
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
BY-SA |
- Increase, Cytotoxicity (hepatocytes)
|
- Increase, hepatocellular adenomas and carcinomas
| |
1.29 |
171 |
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. |
Charles Wood |
BY-SA |
|
| |
1.29 |
490 |
Co-activation of IP3R and RyR leads to reduced IQ through non-cholinergic mechanisms |
Karine Audouze |
All rights reserved |
- Ryanodine receptor activation
- Inositol triphosphate receptor activation
|
- Impairment, Learning and memory
- decreased, Intellectual Quotient
| |
|
403 |
combined unhealthy lifestyle factors leading to metabolic syndrome |
Gillina Bezemer |
BY-SA |
|
| |
|
367 |
Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
- Binding, Thyroid binding globulin in serum
|
- Altered, Amphibian metamorphosis
| |
|
366 |
Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
- Binding, Transthyretin in serum
|
- Altered, Amphibian metamorphosis
| |
|
107 |
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat |
Kristin Lichti-Kaiser |
BY-SA |
- Activation, Constitutive androstane receptor
|
- Increase, hepatocellular adenomas and carcinomas
| Under Review |
1.17 |
39 |
Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response |
Jessica Ponder |
BY-SA |
- Covalent Binding, Protein
|
- Increase, Allergic Respiratory Hypersensitivity Response
| Under Development |
1.20 |
40 |
Covalent Protein binding leading to Skin Sensitisation |
Undefined |
BY-SA |
- Covalent Binding, Protein
|
| WPHA/WNT Endorsed |
1.1 |
177 |
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality |
Kellie Fay |
BY-SA |
- Inhibition, Cyclooxygenase 1 activity
|
- Increased Mortality
- Decrease, Population growth rate
| |
1.29 |
28 |
Cyclooxygenase inhibition leading reproductive failure |
Dan Villeneuve |
BY-SA |
- Inhibition, Cyclooxygenase activity
|
- N/A, Reproductive failure
| |
1.29 |
63 |
Cyclooxygenase inhibition leading to reproductive dysfunction |
Dalma Martinovic-Weigelt |
BY-SA |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
| |
1.29 |
100 |
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior |
Dalma Martinovic-Weigelt |
BY-SA |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
| |
1.29 |
101 |
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release |
Dalma Martinovic-Weigelt |
BY-SA |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
| |
1.29 |
102 |
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition |
Dalma Martinovic-Weigelt |
BY-SA |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
| |
1.29 |
103 |
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint |
Dalma Martinovic-Weigelt |
BY-SA |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
| |
1.29 |
434 |
CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects |
Job Berkhout |
All rights reserved |
|
| |
|
260 |
CYP2E1 activation and formation of protein adducts leading to neurodegeneration |
Jelle Broeders |
BY-SA |
- CYP2E1 Activation
- Protein Adduct Formation
|
| |
|
220 |
Cyp2E1 Activation Leading to Liver Cancer |
Francina Webster |
BY-SA |
|
| WPHA/WNT Endorsed |
1.24 |
368 |
Cytochrome oxidase inhibition leading to olfactory nasal lesions |
Katy Goyak |
BY-SA |
- Inhibition, cytochrome oxidase
|
- Increase, Site of Contact Nasal Tumors
| |
|
109 |
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) |
Charles Wood |
BY-SA |
- Increase, Cytotoxicity (club cells)
|
- Increase, Adenomas/carcinomas (bronchioloalveolar)
| |
1.29 |
116 |
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) |
Charles Wood |
BY-SA |
- Increase, Cytotoxicity (tubular epithelial cells)
|
- Increase, Adenomas/carcinomas (renal tubular)
| |
1.29 |
86 |
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
|
- impaired, Larval development
- Death/Failure, Colony
| |
1.29 |
111 |
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) |
Charles Wood |
BY-SA |
- Decreased, Androgen receptor activity
|
- Increase, Leydig cell tumors
| |
1.29 |
502 |
Decrease, cholesterol synthesis leads to orofacial clefting |
Jacob Reynolds |
All rights reserved |
|
| Under Development |
1.101 |
491 |
Decrease, GLI1/2 target gene expression leads to orofacial clefting |
Jacob Reynolds |
All rights reserved |
- Decrease, GLI1/2 target gene expression
|
| Under Development |
1.101 |
392 |
Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation |
Penny Nymark |
BY-SA |
- Fibrinolysis, decreased
- Bradykinin system, hyperactivated
|
| Under Development |
1.96 |
528 |
Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis |
John Frisch |
BY-SA |
|
- Malformation, cryptorchidism - maldescended testis
| |
|
539 |
Decreased Sodium/Potassium ATPase activity leads to Heart failure |
John Frisch |
BY-SA |
- Decreased Na/K ATPase activity
|
| |
|
307 |
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
BY-SA |
|
- anogenital distance (AGD), decreased
| Under Development |
1.90 |
527 |
Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased |
John Frisch |
BY-SA |
|
| |
|
526 |
Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis |
John Frisch |
BY-SA |
|
- Impaired, Spermatogenesis
| |
|
158 |
Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
BY-SA |
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
157 |
Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation |
Dries Knapen |
BY-SA |
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
156 |
Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
BY-SA |
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
155 |
Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation |
Dries Knapen |
BY-SA |
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
510 |
Demethylation of PPAR promotor leading to vascular disrupting effects |
Yanhong Wei |
All rights reserved |
- peroxisome proliferator activated receptor promoter demethylation
|
- Increase, Vascular disrupting effects
| |
|
432 |
Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia |
Dag Anders Brede |
All rights reserved |
|
| |
|
483 |
Deposition of Energy Leading to Learning and Memory Impairment |
Vinita Chauhan |
BY-SA |
|
- Impairment, Learning and memory
| Under Review |
1.89 |
272 |
Deposition of energy leading to lung cancer |
Vinita Chauhan |
BY-SA |
|
| WPHA/WNT Endorsed |
1.56 |
482 |
Deposition of energy leading to occurrence of bone loss |
Vinita Chauhan |
BY-SA |
|
| Under Review |
1.89 |
478 |
Deposition of energy leading to occurrence of cataracts |
Vinita Chauhan |
BY-SA |
|
| Under Review |
1.89 |
299 |
Deposition of energy leading to population decline via DNA oxidation and follicular atresia |
You Song |
BY-SA |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
| |
|
311 |
Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis |
You Song |
BY-SA |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
| |
|
216 |
Deposition of energy leading to population decline via DNA strand breaks and follicular atresia |
Knut Erik Tollefsen |
BY-SA |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
| |
|
238 |
Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis |
Knut Erik Tollefsen |
BY-SA |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
| |
|
470 |
Deposition of energy leads to abnormal vascular remodeling |
Vinita Chauhan |
BY-SA |
|
- Occurrence, Abnormal Vascular Remodeling
| Under Review |
1.89 |
388 |
Deposition of ionising energy leading to population decline via programmed cell death |
Knut Erik Tollefsen |
BY-SA |
|
- Decrease, Reproduction
- Decrease, Population growth rate
| |
|
387 |
Deposition of ionising energy leading to population decline via mitochondrial dysfunction |
Knut Erik Tollefsen |
BY-SA |
|
- Decrease, Reproduction
- Decrease, Population growth rate
| |
|
461 |
Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis |
Knut Erik Tollefsen |
BY-SA |
|
| |
|
435 |
Deposition of ionising energy leads to population decline via pollen abnormal |
Li Xie |
BY-SA |
|
- Decrease, Reproduction
- Decreased, Population trajectory
| |
|
386 |
Deposition of ionizing energy leading to population decline via inhibition of photosynthesis |
Knut Erik Tollefsen |
BY-SA |
|
- Decrease, Reproduction
- Decrease, Population growth rate
| |
|
396 |
Deposition of ionizing energy leads to population decline via impaired meiosis |
Erica Maremonti |
All rights reserved |
- Deposition of Ionizing Energy
|
- Decrease of egg production and cummulative fecundity
- Decrease, Reproduction
- Decreased, Population size
| |
|
43 |
Disruption of VEGFR Signaling Leading to Developmental Defects |
Undefined |
BY-SA |
|
- Increased, Developmental Defects
| WPHA/WNT Endorsed |
1.6 |
472 |
DNA adduct formation leading to kidney failure |
Manoe Janssen |
BY-SA |
|
| |
|
240 |
DNA Adducts Leading to Liver Hemangiosarcoma |
Undefined |
BY-SA |
|
| |
|
336 |
DNA methyltransferase inhibition leading to population decline (1) |
You Song |
BY-SA |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity
- Decrease, Population growth rate
| |
|
337 |
DNA methyltransferase inhibition leading to population decline (2) |
You Song |
BY-SA |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity
- Decrease, Population growth rate
| |
|
338 |
DNA methyltransferase inhibition leading to population decline (3) |
You Song |
BY-SA |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity
- Decrease, Population growth rate
| |
|
339 |
DNA methyltransferase inhibition leading to population decline (4) |
You Song |
BY-SA |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity
- Decrease, Population growth rate
| |
|
340 |
DNA methyltransferase inhibition leading to transgenerational effects (1) |
You Song |
BY-SA |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity (F3)
- Decrease, Population growth rate
| |
|
341 |
DNA methyltransferase inhibition leading to transgenerational effects (2) |
You Song |
BY-SA |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity (F3)
- Decrease, Population growth rate
| |
|
466 |
Doda decarboxylase leading to mortality |
Donggon Yoo |
BY-SA |
|
| |
|
193 |
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
|
- Altered, Amphibian metamorphosis
| |
1.29 |
377 |
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) |
Gillina Bezemer |
BY-SA |
- Prolonged TLR9 activation
|
- Multi Organ Failure involving Acute Respiratory Distress Syndrome
- Increased Mortality
| |
|
378 |
Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load |
Gillina Bezemer |
BY-SA |
- Toll Like Receptor (TLR) Dysregulation
|
| |
|
167 |
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. |
Charles Wood |
BY-SA |
- prepubertal increase, Estrogen receptor (ER) activity
|
- Increased, adenosquamous carcinomas of endometrium
| |
1.29 |
295 |
Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk |
Andrea Hindman |
BY-SA |
|
| Under Development |
1.79 |
4 |
Ecdysone receptor agonism leading to incomplete ecdysis associated mortality |
Knut Erik Tollefsen |
BY-SA |
- Increase, Ecdysone receptor agonism
|
| |
|
148 |
EGFR Activation Leading to Decreased Lung Function |
Karsta Luettich |
BY-SA |
|
| Under Development |
1.51 |
269 |
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development |
Christopher Goodchild |
BY-SA |
|
| |
|
270 |
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity |
Christopher Goodchild |
All rights reserved |
|
| |
|
310 |
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR |
Jon Doering |
BY-SA |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
| |
|
144 |
Endocytic lysosomal uptake leading to liver fibrosis |
Marina Kuburic |
BY-SA |
- Endocytotic lysosomal uptake
|
| Under Review |
1.47 |
530 |
Endocytotic lysosomal uptake leads to intestinal barrier disruption |
Laure-Alix Clerbaux |
All rights reserved |
- Endocytotic lysosomal uptake
|
- Intestinal barrier, disruption
| |
|
412 |
Endothelial cell dysfunction leading to thromboinflammation |
Luigi Margiotta-Casaluci |
All rights reserved |
|
- Thromboinflammation, Increased
| Under Development |
1.96 |
473 |
Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin |
Danielle Beaton |
BY-SA |
|
- Decrease, Growth
- Decreased, Reproductive Success
| |
|
162 |
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse |
Charles Wood |
BY-SA |
|
- Increase, Adenomas/carcinomas (follicular cell)
| |
1.29 |
72 |
Epigenetic modification of PPARG leading to adipogenesis |
Michelle Angrish |
BY-SA |
- peroxisome proliferator activated receptor promoter demethylation
- chronic high fat diet
|
| |
1.29 |
115 |
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) |
Charles Wood |
BY-SA |
- Increase, Cytotoxicity (epithelial cells)
|
- Increase, Papillomas/carcinomas (squamous cells)
| |
1.29 |
53 |
ER agonism leading to reduced survival due to renal failure |
Undefined |
BY-SA |
- Agonism, Estrogen receptor
|
| |
1.29 |
52 |
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males |
Undefined |
BY-SA |
- Agonism, Estrogen receptor
|
| |
1.29 |
199 |
ER mediated breast cancer AOP |
Molly M Morgan |
BY-SA |
|
| |
|
493 |
ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity |
Min Ji Kim |
All rights reserved |
- Estrogen receptor alpha inactivation
|
- Metabolically unhealthy Obesity
| |
|
497 |
ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome |
Min Ji Kim |
All rights reserved |
- Estrogen receptor alpha inactivation
|
- Insulin resistance, increased
- Metabolic syndrome
| |
|
521 |
Essential element imbalance leads to reproductive failure via oxidative stress |
Travis Karschnik |
BY-SA |
- Increased, essential element imbalance
|
- Decreased, Viable Offspring
| |
|
522 |
Estrogen antagonism leading to increased risk of autism-like behavior |
Kanglong Cui |
Open for adoption |
- Antagonism, Estrogen receptor
|
| |
|
146 |
Estrogen Receptor Activation and Female Precocious Puberty |
Undefined |
BY-SA |
|
| |
1.29 |
200 |
Estrogen receptor activation leading to breast cancer |
Molly M Morgan |
Open for adoption |
- Activation, Estrogen receptor
|
| |
|
536 |
Estrogen receptor agonism leading to reduced survival and population growth due to renal failure |
Camille Baettig |
BY-SA |
- Agonism, Estrogen receptor
|
| |
|
29 |
Estrogen receptor agonism leading to reproductive dysfunction |
Undefined |
BY-SA |
- Agonism, Estrogen receptor
|
- Decrease, Population growth rate
- Altered, Reproductive behaviour
- Altered, Larval development
- Impaired development of, Reproductive organs
| |
1.29 |
537 |
Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver |
Jason M. O'Brien |
BY-SA |
- Agonism, Estrogen receptor
|
- Reduction, Cumulative fecundity and spawning
| |
|
445 |
Estrogen Receptor Alpha Agonism leads to Impaired Reproduction |
John Hoang |
BY-SA |
- Activation, estrogen receptor alpha
|
| |
|
30 |
Estrogen receptor antagonism leading to reproductive dysfunction |
Dan Villeneuve |
BY-SA |
- Antagonism, Estrogen receptor
|
- Decrease, Population growth rate
| Under Review |
1.12 |
95 |
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival |
Kellie Fay |
BY-SA |
- Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
|
| |
1.29 |
501 |
Excessive iron accumulation leading to neurological disorders |
Young Jun Kim |
Open for adoption |
- Increased intracelluar Iron accumulation
|
| |
|
325 |
Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death |
You Song |
BY-SA |
- Increase, Reactive Oxygen Species
|
| |
|
332 |
Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation |
You Song |
BY-SA |
- Increase, Reactive Oxygen Species
|
| |
|
324 |
Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death |
You Song |
BY-SA |
- Increase, Reactive Oxygen Species
|
| |
|
331 |
Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage and reduced cell proliferation |
You Song |
BY-SA |
- Increase, Reactive Oxygen Species
|
| |
|
326 |
Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell death |
You Song |
BY-SA |
- Increase, Reactive Oxygen Species
|
| |
|
333 |
Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation |
You Song |
BY-SA |
- Increase, Reactive Oxygen Species
|
| |
|
327 |
Excessive reactive oxygen species production leading to mortality (1) |
You Song |
BY-SA |
- Increase, Reactive Oxygen Species
|
| |
|
328 |
Excessive reactive oxygen species production leading to mortality (2) |
You Song |
BY-SA |
- Increase, Reactive Oxygen Species
|
| |
|
329 |
Excessive reactive oxygen species production leading to mortality (3) |
You Song |
BY-SA |
- Increase, Reactive Oxygen Species
|
| |
|
330 |
Excessive reactive oxygen species production leading to mortality (4) |
You Song |
BY-SA |
- Increase, Reactive Oxygen Species
|
| |
|
541 |
Excessive ROS generation leading to increased incidence of vascular calcification by VSMC phenotype switching |
Ruiyang Ding |
All rights reserved |
|
| |
|
409 |
Frustrated phagocytosis leads to malignant mesothelioma |
Penny Nymark |
BY-SA |
|
| |
|
303 |
Frustrated phagocytosis-induced lung cancer |
Carole Seidel |
BY-SA |
|
| Under Development |
1.86 |
401 |
G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects |
Fei Li |
BY-SA |
- protein-coupled estrogen receptor 1 (GPER) activation
|
| |
|
217 |
Gastric ulcer formation |
Lyle Burgoon |
Open for adoption |
|
- Inhibit, gastric ulcer formation
- Activated, gastric ulcer formation
| |
|
64 |
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility |
Undefined |
BY-SA |
- Glucocorticoid Receptor Agonist, Activation
|
| |
1.29 |
318 |
Glucocorticoid Receptor activation leading to hepatic steatosis |
Chander K. Negi |
BY-SA |
- Activation, Glucocorticoid Receptor
|
- Increased, Liver Steatosis
| |
|
14 |
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility |
Carlie LaLone |
BY-SA |
- Activation, Glucocorticoid Receptor
|
- Increased, Disease susceptibility
| |
1.29 |
334 |
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration |
Alexander Cole |
BY-SA |
- Activation, Glucocorticoid Receptor
|
- Decrease, Population growth rate
| |
|
113 |
Glutamate-gated chloride channel activation leading to acute mortality |
Helen Poynton |
BY-SA |
- Activation, Glutamate-gated chloride channel
|
- Increased Mortality
- Decreased, population 1
| |
1.29 |
161 |
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality |
Knut Erik Tollefsen |
BY-SA |
- Activation, Glutamate-gated chloride channels
|
| |
|
492 |
Glutathione conjugation leading to reproductive dysfunction via oxidative stress |
Leonardo Vieira |
All rights reserved |
|
| |
|
524 |
Gluten intake leading to celiac disease - under development |
Antonio Fernandez Dumont |
All rights reserved |
- Human leukocyte antigen DQ2/8-gluten complexes, formation
- Gluten-reactive T cell receptors, generation
- Gluten-reactive and transglutaminase 2 reactive B cell receptors, generation
|
| |
|
168 |
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. |
Charles Wood |
BY-SA |
|
- Increased, Adenomas/carcinomas (mammary)
| |
1.29 |
169 |
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. |
Charles Wood |
BY-SA |
|
- Increased, adenomas (pituitary)
| |
1.29 |
410 |
GSK3beta inactivation leading to increased mortality via defects in developing inner ear |
Vid Modic |
BY-SA |
|
- Increased Mortality
- Decrease, Population growth rate
| |
|
211 |
Handbook development AOP |
Dan Villeneuve |
BY-SA |
|
| |
1.29 |
229 |
Helicobacter pylori to gastric ulcer |
Lyle Burgoon |
Open for adoption |
- Helicobacter pylori infection
|
- Activated, gastric ulcer formation
| |
|
194 |
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
- Activation, Hepatic nuclear receptor(s)
|
- Altered, Amphibian metamorphosis
| |
1.29 |
433 |
hERG channel blockade leading to sudden cardiac death |
Egemen Bilgin |
BY-SA |
|
| |
|
99 |
Histamine (H2) receptor antagonism leading to reduced survival |
Kellie Fay |
BY-SA |
- Antagonism, Histamine Receptor (H2)
|
- Decreased, survival
- Increased, predation
| |
1.29 |
212 |
Histone deacetylase inhibition leading to testicular atrophy |
Shihori Tanabe |
BY-SA |
- Histone deacetylase inhibition
|
| WPHA/WNT Endorsed |
1.52 |
274 |
Histone deacetylase inhibition leads to impeded craniofacial development |
Marvin Martens |
BY-SA |
- Histone deacetylase inhibition
|
- Facial cartilage structures are reduced in size and morphologically distorted
| |
|
275 |
Histone deacetylase inhibition leads to neural tube defects |
Marvin Martens |
BY-SA |
- Histone deacetylase inhibition
|
| |
|
124 |
HMG-CoA reductase inhibition leading to decreased fertility |
Kellie Fay |
BY-SA |
- Inhibition, HMG-CoA reductase
|
| |
1.29 |
59 |
HNF4alpha suppression leading to hepatic steatosis |
Michelle Angrish |
BY-SA |
|
| |
1.29 |
114 |
HPPD inhibition leading to corneal papillomas and carcinomas (in rat) |
Charles Wood |
BY-SA |
- Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
|
- Increase, Papillomas/carcinomas (squamous cells)
| |
1.29 |
384 |
Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease |
Young Jun Kim |
BY-SA |
- Hyperactivation of ACE/Ang-II/AT1R axis
|
| |
|
440 |
Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia |
Kalyan Gayen |
All rights reserved |
- Suppression, Estrogen receptor (ER) activity
|
- Promotion, ovarian adenomas
- Promotion, Ovarian Cancer
| Under Development |
1.104 |
278 |
IKK complex inhibition leading to liver injury |
Nanette Vrijenhoek |
BY-SA |
|
- Necrotic Tissue
- Liver Injury
| |
|
408 |
Imbalance in redox homeostasis leading to structural damage to tissues |
Fei Li |
BY-SA |
|
| |
|
362 |
Immune mediated hepatitis |
Jung-Hwa Oh |
BY-SA |
- benzoquinone imine and acylglucuronide metabolites
|
- Immune mediated hepatitis
| |
|
277 |
Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response |
Takao Ashikaga |
BY-SA |
- Impaired IL-1R1 signaling in T cell
|
- Impairment, T-cell dependent antibody response
| WPHA/WNT Endorsed |
1.48 |
400 |
Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males |
Terje Svingen |
BY-SA |
- Increased (ectopic) all-trans retinoic acid concentration
|
| |
|
293 |
Increased DNA damage leading to increased risk of breast cancer |
Jessica Helm |
BY-SA |
|
- Increase, Mutations
- Increased, Ductal Hyperplasia
- N/A, Breast Cancer
| Under Development |
1.80 |
112 |
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) |
Charles Wood |
BY-SA |
- Increase, Dopaminergic activity
|
- Increase, Endometrial adenocarcinomas
| |
1.29 |
498 |
Increased LCN2/iron complex leading to neurological disorders |
Young Jun Kim |
Open for adoption |
- Increased LCN2/iron complex binds to SLC22A17 receptor in neuron
|
| |
|
81 |
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
|
- Decrease, Number of worker bees
- Death/Failure, Colony
| |
1.29 |
294 |
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer |
Jessica Helm |
BY-SA |
- Increase in reactive oxygen and nitrogen species (RONS)
|
- Increase, DNA damage
- Increase, Mutations
- Increased, Ductal Hyperplasia
- N/A, Breast Cancer
| Under Development |
1.80 |
488 |
Increased reactive oxygen species production leading to decreased cognitive function |
Eliska Kuchovska |
BY-SA |
- Increase, Reactive Oxygen Species
|
- Cognitive function, decreased
| |
|
431 |
Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) |
Qi Wang |
BY-SA |
|
- Gestational diabetes mellitus
| |
|
298 |
Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer |
Shihori Tanabe |
BY-SA |
- Increases in cellular reactive oxygen species
- Chronic reactive oxygen species
|
- Treatment-resistant gastric cancer
| Under Review |
1.58 |
349 |
Inhibition of 11β-hydroxylase leading to decresed population trajectory |
Young Jun Kim |
BY-SA |
- 11β-hydroxylase inhibition
|
- Decrease, Population growth rate
| Under Development |
1.93 |
348 |
Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory |
Young Jun Kim |
BY-SA |
|
- Decrease, Population growth rate
| Under Development |
1.93 |
288 |
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) |
Bérénice COLLET |
BY-SA |
- Inhibition, Cytochrome P450 enzyme (CYP17A1) activity
|
- Malformation, cryptorchidism - maldescended testis
| |
|
289 |
Inhibition of 5α-reductase leading to impaired fecundity in female fish |
Young Jun Kim |
BY-SA |
|
- Decrease, Population growth rate
| Under Development |
1.81 |
120 |
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) |
Charles Wood |
BY-SA |
- Inhibition, 5α-reductase activity
|
- Increase, Leydig cell tumors
| |
1.29 |
398 |
Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary |
Terje Svingen |
BY-SA |
- Inhibition of ALDH1A (RALDH)
|
| Under Development |
1.97 |
383 |
Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis |
Young Jun Kim |
BY-SA |
- Induced dysregulation of ACE2
|
| Under Development |
1.96 |
154 |
Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response |
Takumi Ohishi |
BY-SA |
- Inhibition, Calcineurin Activity
|
- Impairment, T-cell dependent antibody response
| WPHA/WNT Endorsed |
1.38 |
276 |
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome |
Marvin Martens |
BY-SA |
- Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
|
- Chemical induced Fanconi syndrome
| |
|
218 |
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity |
Florence Pagé-Larivière |
BY-SA |
- CYP7B activity, inhibition
|
- Decrease, Population growth rate
| |
|
219 |
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior |
Florence Pagé-Larivière |
BY-SA |
- CYP7B activity, inhibition
|
- Decrease, Population growth rate
| |
|
301 |
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis |
Young Jun Kim |
BY-SA |
- Inhibition of cystathionine beta-synthase
|
- Impaired,anterior-posterior axis development
| |
|
213 |
Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) |
Lyle Burgoon |
Open for adoption |
- Inhibition, Fatty Acid Beta Oxidation
|
| |
|
399 |
Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) |
Vid Modic |
BY-SA |
|
- Increased Mortality
- Decrease, Population growth rate
| |
|
32 |
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors |
Undefined |
BY-SA |
|
| |
|
110 |
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) |
Charles Wood |
BY-SA |
- Inhibition, Na+/I- symporter (NIS)
|
- Increase, Adenomas/carcinomas (follicular cell)
| |
1.29 |
315 |
Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response |
Yasuhiro Yoshida |
BY-SA |
|
- Impairment of T-cell dependent antibody response
| Under Development |
1.74 |
242 |
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity |
Stefan Scholz |
Open for adoption |
- Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
|
- Growth, reduction
- Decreased, survival
| |
|
256 |
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity |
Angela Mally |
BY-SA |
- Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)
|
- Occurrence, Kidney toxicity
| Under Development |
1.43 |
437 |
Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity |
Baki Sadi |
BY-SA |
- Inhibition, Mitochondrial Electron Transport Chain Complexes
|
- Occurrence, Kidney toxicity
| Under Development |
1.99 |
285 |
Inhibition of N-linked glycosylation leads to liver injury |
Marvin Martens |
BY-SA |
- Inhibition of N-linked glycosylation
|
| |
|
54 |
Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment |
Anna Price |
BY-SA |
- Inhibition, Na+/I- symporter (NIS)
|
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.28 |
108 |
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
BY-SA |
- Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
|
- Increase, hepatocellular adenomas and carcinomas
| |
1.29 |
436 |
Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries |
Gina Mennen |
BY-SA |
- Inhibition of ALDH1A (RALDH)
|
- transposition of the great arteries
| |
|
297 |
Inhibition of retinaldehyde dehydrogenase leads to population decline |
Young Jun Kim |
BY-SA |
- Retinaldehyde dehydrogenase inhibition
|
- Decrease, Population growth rate
| Under Development |
1.77 |
3 |
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits |
Andrea Terron |
BY-SA |
- Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
|
- Parkinsonian motor deficits
| WPHA/WNT Endorsed |
1.33 |
119 |
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) |
Charles Wood |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Increase, Adenomas/carcinomas (follicular cell)
| |
1.29 |
271 |
Inhibition of thyroid peroxidase leading to impaired fertility in fish |
June-Woo Park |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Reduction, Cumulative fecundity and spawning
| Under Development |
1.59 |
42 |
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Kevin Crofton |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Cognitive function, decreased
| WPHA/WNT Endorsed |
1.10 |
292 |
Inhibition of tyrosinase leads to decreased population in fish |
Young Jun Kim |
BY-SA |
|
- Decrease, Population growth rate
| Under Development |
1.78 |
489 |
Inhibition of voltage-gated sodium channels leading to decreased cognition |
Eliska Kuchovska |
BY-SA |
- Binding to voltage-gated sodium channel
|
- Cognitive function, decreased
| |
|
451 |
Interaction with lung resident cell membrane components leads to lung cancer |
Penny Nymark |
BY-SA |
- Substance interaction with the lung resident cell membrane components
|
| |
|
152 |
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity |
Kristie Sullivan |
BY-SA |
- Binding, Transthyretin in serum
|
- Cognitive function, decreased
| Under Development |
1.41 |
136 |
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors |
Undefined |
BY-SA |
- Decrease, Intracellular pH
|
- Increase, Site of Contact Nasal Tumors
| Under Review |
2.7 |
188 |
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
- Inhibition, Iodotyrosine deiodinase (IYD)
|
- Altered, Amphibian metamorphosis
| |
1.29 |
444 |
Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability |
Deborah Oughton |
BY-SA |
- Deposition of Energy
- Increase in reactive oxygen and nitrogen species (RONS)
- Increase, DNA damage
|
- Decrease, Population growth rate
| |
|
441 |
Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation |
Olivier ARMANT |
BY-SA |
|
- Increase risk, microcephaly
| |
|
160 |
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality |
Knut Erik Tollefsen |
BY-SA |
- Activation, ionotropic GABA Receptor chloride channel
|
| |
|
208 |
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure |
Jinhee Choi |
All rights reserved |
|
| |
|
201 |
Juvenile hormone receptor agonism leading to male offspring induction associated population decline |
Knut Erik Tollefsen |
BY-SA |
- Activation, Juvenile hormone receptor
|
- Increased, Male offspring
- Decline, Population
- Alteration, Food-web structures
| |
|
128 |
Kidney dysfunction by decreased thyroid hormone |
Jung-Hwa Oh |
BY-SA |
- Thyroid hormone synthesis, Decreased
|
- Occurrence, Kidney toxicity
| Under Development |
1.40 |
447 |
Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways |
Yann GUEGUEN |
BY-SA |
|
- Increased, Kidney Failure
| |
|
33 |
Kidney toxicity induced by activation of 5HT2C |
Kevin Crofton |
Open for adoption |
|
- Increased, Kidney Failure
| |
|
467 |
Knickkopf leading to mortality |
Donggon Yoo |
BY-SA |
- Decrease, 20-hydroxyecdysone
|
| |
|
261 |
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility |
Luigi Margiotta-Casaluci |
All rights reserved |
- Blockade, L-Type Calcium Channels
|
| Under Development |
1.45 |
283 |
L-type calcium channel blockade leading to hypotension |
Luigi Margiotta-Casaluci |
All rights reserved |
|
| Under Development |
1.45 |
262 |
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology |
Luigi Margiotta-Casaluci |
All rights reserved |
|
| Under Development |
1.45 |
241 |
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis |
Marvin Martens |
BY-SA |
- Activation, Latent Transforming Growth Factor Beta 1
|
| |
|
518 |
Liver X Receptor (LXR) activation leads to liver steatosis |
John Frisch |
BY-SA |
|
- Increased, Liver Steatosis
| |
|
302 |
Lung surfactant function inhibition leading to decreased lung function |
Jorid Birkelund Sørli |
BY-SA |
- Inhibition of lung surfactant function
|
| Under Development |
1.87 |
309 |
Luteinizing hormone receptor antagonism leading to reproductive dysfunction |
Young Jun Kim |
BY-SA |
|
- Decline, Population trajectory
| |
|
34 |
LXR activation leading to hepatic steatosis |
Undefined |
BY-SA |
- Activation, LXR
- peroxisome proliferator activated receptor promoter demethylation
|
| |
|
222 |
Mental stress to agitation |
Lyle Burgoon |
Open for adoption |
- Increased, glucocorticoid receptor activity
|
| |
|
221 |
Mental stress to depression |
Lyle Burgoon |
Open for adoption |
- Increased, glucocorticoid receptor activity
|
| |
|
404 |
Metabolic Syndrome leading to Toll Like Receptor dysregulation |
Gillina Bezemer |
BY-SA |
|
| |
|
279 |
Microtubule interacting drugs lead to peripheral neuropathy |
Marvin Martens |
BY-SA |
- Binding of microtubule stabilizing agents (MSA) to microtubules
|
- Sensory axonal peripheral neuropathy
| |
|
290 |
Mitochondrial ATP synthase antagonism leading to growth inhibition (1) |
You Song |
BY-SA |
- Increase, Mitochondrial ATP synthase antagonism
|
| |
|
291 |
Mitochondrial ATP synthase antagonism leading to growth inhibition (2) |
You Song |
BY-SA |
- Increase, Mitochondrial ATP synthase antagonism
|
| |
|
286 |
Mitochondrial complex III antagonism leading to growth inhibition (1) |
You Song |
BY-SA |
- Increase, Mitochondrial complex III antagonism
|
| |
|
287 |
Mitochondrial complex III antagonism leading to growth inhibition (2) |
You Song |
BY-SA |
- Increase, Mitochondrial complex III antagonism
|
| |
|
273 |
Mitochondrial complex inhibition leading to liver injury |
Wanda van der Stel |
BY-SA |
- Increase, Mitochondrial complex III antagonism
- Mitochondrial Complex IV inhibition
- Mitochondrial Complex V inhibition
- Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
- Inhibition, NADH-ubiquinone oxidoreductase (complex I)
- Binding of inhibitor to mitochondrial complex III
- Binding of inhibitor to mitochondrial complex IV
- Binding of inhibitor to mitochondrial complex V
|
- Necrotic Tissue
- Liver Injury
| |
|
480 |
Mitochondrial complexes inhibition leading to heart failure via decreased ATP production |
Alexandra Schaffert |
BY-SA |
- Inhibition, Mitochondrial Electron Transport Chain Complexes
|
- Decrease Left Ventricular function
| Under Development |
1.102 |
479 |
Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress |
Sivakumar Murugadoss |
BY-SA |
- Inhibition, Mitochondrial Electron Transport Chain Complexes
|
- Decrease Left Ventricular function
| Under Development |
1.102 |
373 |
Mitochondrial dysfunction to metabolic diseases |
Chander K. Negi |
BY-SA |
|
| |
|
66 |
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis |
Undefined |
BY-SA |
- Decreased testosterone by the fetal Leydig cells, Increased corticosterone
- Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
|
- Decreased sperm quantity / quality in the adult, Decreased fertility
| |
1.29 |
68 |
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome |
Undefined |
BY-SA |
- Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
|
- Decreased sperm quantity / quality in the adult, Decreased fertility
| |
1.29 |
69 |
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell |
Undefined |
BY-SA |
- Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol
- Decreased Cholesterol, Decreased Uptake of Lipoproteins
- Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
|
- Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
| |
1.29 |
67 |
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis |
Undefined |
BY-SA |
- Decreased testosterone by the fetal Leydig cells, Increased estradiol
- Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists
|
- Decreased sperm quantity / quality in the adult, Decreased fertility
| |
1.29 |
71 |
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation |
Undefined |
BY-SA |
- Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
|
- Decreased sperm quantity or quality in the adult, Decreased fertility
| |
1.29 |
74 |
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis |
Undefined |
BY-SA |
- Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
|
- Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
| |
1.29 |
70 |
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell |
Undefined |
BY-SA |
- Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
|
- Decreased sperm quantity or quality in the adult, Decreased fertility
| |
1.29 |
215 |
Molecular events lead to epilepsy |
Lyle Burgoon |
Open for adoption |
|
- Increase, seizure
- Increased, hippocampal hyperdepolarization
- Increased, epilepsy
| |
|
234 |
Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition |
Timothy Allen |
BY-SA |
- Mu Opioid Receptor Agonism
|
| |
|
233 |
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening |
Timothy Allen |
BY-SA |
- Mu Opioid Receptor Agonism
|
| |
|
516 |
Na+ /K+ -ATPase inhibition leading to hypertension |
Michelle Angrish |
All rights reserved |
- Decreased Na/K ATPase activity
|
| |
|
207 |
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans |
Jinhee Choi |
All rights reserved |
- Activation, NADPH Oxidase
|
| |
|
35 |
Narcosis leading to respiratory failure |
Dries Knapen |
BY-SA |
- Accumulation, Biological membranes
|
| Under Development |
1.2 |
214 |
Network of SSRIs (selective serotonin reuptake inhibitors) |
Lyle Burgoon |
Open for adoption |
|
- Increased, seizure
- Increased, agitation
- Increased, depression
- Increase, hypertension
| |
|
232 |
NFE2/Nrf2 repression to steatosis |
Lyle Burgoon |
Open for adoption |
|
- Increased, Liver Steatosis
| |
|
61 |
NFE2L2/FXR activation leading to hepatic steatosis |
Michelle Angrish |
BY-SA |
- Activation, NRF2
- Activation, NR1H4
|
- Increased, Liver Steatosis
| |
1.29 |
77 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
| |
1.29 |
87 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
| |
1.29 |
88 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
| |
1.29 |
78 |
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
- impaired, Larval development
- Death/Failure, Colony
| |
1.29 |
90 |
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
- impaired, Larval development
- Death/Failure, Colony
| |
1.29 |
80 |
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
- Decrease, Number of worker bees
- impaired, Hive thermoregulation
- Death/Failure, Colony
| |
1.29 |
79 |
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
| |
1.29 |
178 |
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
| |
1.29 |
89 |
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
| |
1.29 |
184 |
Nosema infection causes abnormal role change that leads to colony loss/failure |
Carlie LaLone |
BY-SA |
|
| |
1.29 |
183 |
Nosema infection increases energetic demands leading to colony loss/failure |
Carlie LaLone |
BY-SA |
|
| |
1.29 |
60 |
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis |
Michelle Angrish |
BY-SA |
|
- Increased, Liver Steatosis
| |
1.29 |
58 |
NR1I3 (CAR) suppression leading to hepatic steatosis |
Michelle Angrish |
BY-SA |
- Suppression, Constitutive androstane receptor, NR1l3
- Inhibition, PPAR alpha
- Activation, LXR
- peroxisome proliferator activated receptor promoter demethylation
|
- Increased, Liver Steatosis
| |
1.29 |
509 |
Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction |
Yanhong Wei |
All rights reserved |
|
- Increase, Vascular disrupting effects
| |
|
508 |
Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway |
Yanhong Wei |
All rights reserved |
|
- Increase, Vascular disrupting effects
| |
|
507 |
Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway |
Yanhong Wei |
All rights reserved |
|
- Increase, Vascular disrupting effects
| |
|
227 |
NSAID induced PTGS1 inactivation to gastric ulcer |
Lyle Burgoon |
Open for adoption |
|
- Activated, gastric ulcer formation
| |
|
228 |
NSAID induced PTGS2 inactivation to gastric ulcer |
Lyle Burgoon |
Open for adoption |
|
- Activated, gastric ulcer formation
| |
|
138 |
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality |
Kellie Fay |
BY-SA |
- Inhibition, organic anion transporter 1 (OAT1)
|
- Increased Mortality
- Decrease, Population growth rate
| |
1.29 |
405 |
Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function |
SAROJ AMAR |
BY-SA |
- Acetylcholinesterase (AchE) Inhibition
|
- Cognitive function, decreased
| |
|
413 |
Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure |
Zarin Hossain |
BY-SA |
- Oxidation, Glutathione (To be considered with MIE)
|
| |
|
31 |
Oxidation of iron in hemoglobin leading to hematotoxicity |
Undefined |
Open for adoption |
- N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)
|
| Under Development |
1.16 |
296 |
Oxidative DNA damage leading to chromosomal aberrations and mutations |
Carole Yauk |
BY-SA |
- Increase, Oxidative DNA damage
|
- Increase, Mutations
- Increase, Chromosomal aberrations
| WPHA/WNT Endorsed |
1.76 |
540 |
Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production |
Kevin Brix |
All rights reserved |
- Increased, Reactive oxygen species
|
- Decrease, Population growth rate
| |
|
411 |
Oxidative stress Leading to Decreased Lung Function |
Karsta Luettich |
BY-SA |
|
| |
|
424 |
Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction |
Karsta Luettich |
BY-SA |
|
| |
|
425 |
Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 |
Karsta Luettich |
BY-SA |
|
| |
|
239 |
Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling |
Undefined |
BY-SA |
|
| |
|
192 |
Pendrin inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
|
- Altered, Amphibian metamorphosis
| |
1.29 |
149 |
Peptide Oxidation Leading to Hypertension |
Frazer Lowe |
BY-SA |
|
| Under Development |
1.50 |
11 |
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol |
Jun Kanno |
BY-SA |
|
| Under Development |
2.5 |
529 |
Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis |
Erik Mylroie |
BY-SA |
- Stressor binding PPAR isoforms
|
- Increased, Liver Steatosis
| |
|
36 |
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis |
Michelle Angrish |
BY-SA |
- Decreased, PPAR-alpha activation
- Decreased, PPAR-beta activation
- Decreased, PPAR-gamma activation
|
- Increased, Liver Steatosis
| |
1.29 |
206 |
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis |
Jinhee Choi |
All rights reserved |
|
| Under Development |
1.54 |
209 |
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP |
Jinhee Choi |
All rights reserved |
|
| |
|
130 |
Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity |
Jung-Hwa Oh |
BY-SA |
- Inhibition, Phospholipase A
|
- Formation, Liver fibrosis
| Under Development |
1.39 |
371 |
Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone |
You Song |
BY-SA |
|
| |
|
369 |
Photosystem II antagonism leading to growth inhibition via oxidative damage |
You Song |
BY-SA |
|
| |
|
370 |
Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis |
You Song |
BY-SA |
|
| |
|
514 |
PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV |
Hui Li |
All rights reserved |
|
| |
|
446 |
PM-related Adverse outcome pathway frameworks on various systems |
Tianyu Li |
BY-SA |
|
| |
|
454 |
PM2.5-related AOP frameworks on liver diseases |
Zhou Du |
BY-SA |
|
| |
|
166 |
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse |
Charles Wood |
BY-SA |
|
- Increased, Pancreatic acinar tumors
| |
1.29 |
323 |
PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone |
Jennifer Olker |
BY-SA |
|
- Decreased, Viable Offspring
- Decrease, Population growth rate
| |
|
421 |
PPARG activation leading to intrahepatic cholestasis |
Yuan Jin |
All rights reserved |
|
| |
|
163 |
PPARgamma activation leading to sarcomas in rats, mice, and hamsters |
Charles Wood |
BY-SA |
- Activation of specific nuclear receptors, PPAR-gamma activation
|
| |
1.29 |
18 |
PPARα activation in utero leading to impaired fertility in males |
Elise Grignard |
BY-SA |
|
- impaired, Fertility
- Malformation, Male reproductive tract
| Under Review |
1.21 |
37 |
PPARα activation leading to hepatocellular adenomas and carcinomas in rodents |
Chris Corton |
BY-SA |
|
- Increase, hepatocellular adenomas and carcinomas
| Under Development |
1.17 |
51 |
PPARα activation leading to impaired fertility in adult male rodents |
Elise Grignard |
BY-SA |
|
| Under Development |
1.21 |
517 |
Pregnane X Receptor (PXR) activation leads to liver steatosis |
John Frisch |
BY-SA |
- Activation, Pregnane-X receptor, NR1l2
|
- Increased, Liver Steatosis
| |
|
230 |
presynaptic neuron 1 activation to epilepsy |
Lyle Burgoon |
Open for adoption |
- Activated, presynaptic neuron 1
|
| |
|
231 |
presynaptic neuron 2 repression to epilepsy |
Lyle Burgoon |
Open for adoption |
- Reduced, presynaptic neuron 2 activity
|
| |
|
122 |
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation |
Dalma Martinovic-Weigelt |
BY-SA |
- Inhibition, Prolyl hydroxylases
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
| |
1.29 |
38 |
Protein Alkylation leading to Liver Fibrosis |
Brigitte Landesmann |
BY-SA |
|
| WPHA/WNT Endorsed |
1.14 |
185 |
Queen egg-laying decrease leads to colony loss/failure |
Carlie LaLone |
BY-SA |
|
| |
1.29 |
513 |
Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway |
John Frisch |
BY-SA |
- Increased, Reactive oxygen species
|
| |
|
505 |
Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway |
John Frisch |
BY-SA |
- Increased, Reactive oxygen species
|
| |
|
453 |
Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population |
Ruiyang Ding |
BY-SA |
|
| |
|
438 |
reactive oxygen species generation leading to increased cardiovascular morbidity and mortality |
Yu Yang |
All rights reserved |
|
| |
|
469 |
Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population |
Ruiyang Ding |
BY-SA |
|
| |
|
257 |
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity |
Angela Mally |
BY-SA |
- Binding of substrate, endocytic receptor
|
- Occurrence, Kidney toxicity
| Under Development |
1.43 |
512 |
Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level |
Ana-Andreea Cioca |
All rights reserved |
|
| |
|
321 |
Reduced environmental pH leading to thinner shells in Mytilus edulis |
James Ducker |
BY-SA |
|
| |
|
525 |
Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory |
Diana Lupu |
Open for adoption |
- Binding of antagonist to thyroid hormone receptor
- Binding of antagonist to glucocorticoid hormone receptor
- Binding of (ant)agonist to liver X receptor
- Binding of (ant)agonist to peroxisome proliferator–activated receptor alpha
|
- Impairment, Learning and memory
| |
|
245 |
Reduction in photophosphorylation leading to growth inhibition in aquatic plants |
Knut Erik Tollefsen |
BY-SA |
- Increase, Uncoupling of photophosphorylation
|
| |
|
258 |
Renal protein alkylation leading to kidney toxicity |
Angela Mally |
BY-SA |
|
- Occurrence, Kidney toxicity
| Under Development |
1.43 |
532 |
Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function |
Diana Lupu |
Open for adoption |
- Agonism, Retinoic acid receptor
|
- Locomotor function. Impaired
| |
|
520 |
Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory |
Diana Lupu |
Open for adoption |
- Agonism, Retinoic acid receptor
|
- Impairment, Learning and memory
| |
|
523 |
Retinoic acid receptor agonism during neurodevelopment leading to microcephaly |
Diana Lupu |
Open for adoption |
- Agonism, Retinoic acid receptor
|
- Increase risk, microcephaly
| |
|
533 |
Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory |
Diana Lupu |
Open for adoption |
- Antagonism, Retinoic acid receptors
|
- Impairment, Learning and memory
| |
|
448 |
ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality |
Ruiyang Ding |
BY-SA |
|
| |
|
342 |
S-adenosylmethionine depletion leading to population decline (1) |
You Song |
BY-SA |
- Inhibition, Chitin synthase 1
|
| |
|
343 |
S-adenosylmethionine depletion leading to population decline (2) |
You Song |
BY-SA |
- Increase, Sulfonylurea receptor binding
|
| |
|
406 |
SARS-CoV-2 infection leading to hyperinflammation |
Hasmik Yepiskoposyan |
All rights reserved |
|
| |
|
407 |
SARS-CoV-2 infection leading to pyroptosis |
Hasmik Yepiskoposyan |
All rights reserved |
|
| |
|
394 |
SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) |
Sandra Coecke |
BY-SA |
|
- impaired olfactory function (anosmia)
| Under Development |
1.96 |
426 |
SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. |
Evangelos-Panagiotis Daskalopoulos |
BY-SA |
|
| |
|
259 |
Sensitization induction of the intestinal tract by food proteins |
Erwin L Roggen |
BY-SA |
|
| |
|
236 |
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition |
Timothy Allen |
BY-SA |
- Serotonin 1A Receptor Agonism
|
| |
|
235 |
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening |
Timothy Allen |
BY-SA |
- Serotonin 1A Receptor Agonism
|
| |
|
225 |
Serotonin transporter activation to agitation |
Lyle Burgoon |
Open for adoption |
|
| |
|
224 |
Serotonin transporter activation to depression |
Lyle Burgoon |
Open for adoption |
- Increased, serotonin transporter activity
|
| |
|
223 |
Serotonin transporter activation to seizure |
Lyle Burgoon |
Open for adoption |
- Increased, serotonin transporter activity
|
| |
|
197 |
Sodium channel (Nav1.1) inhibition leading to population decline |
Kellie Fay |
BY-SA |
- Inhibition, sodium channel
|
| |
1.29 |
94 |
Sodium channel inhibition leading to congenital malformations |
Kellie Fay |
BY-SA |
- Inhibition, sodium channel
|
| |
1.29 |
93 |
sodium channel inhibition leading to increased predation |
Kellie Fay |
BY-SA |
- Inhibition, sodium channel
|
| |
1.29 |
91 |
Sodium channel inhibition leading to reduced survival |
Kellie Fay |
BY-SA |
- Inhibition, sodium channel
|
- Reduced, feeding 1
- Increased, predation
- Reduced, survival
| |
1.29 |
134 |
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Mary Gilbert |
BY-SA |
- Inhibition, Na+/I- symporter (NIS)
|
- Cognitive function, decreased
| |
1.29 |
176 |
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
- Inhibition, Na+/I- symporter (NIS)
|
- Altered, Amphibian metamorphosis
| |
1.29 |
226 |
SSRI (Selective serotonin reuptake inhibitor) to hypertension |
Lyle Burgoon |
Open for adoption |
- Decreased, serotonin transporter activity
|
| |
|
313 |
Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease |
Hiroyuki Komatsu |
BY-SA |
|
| Under Development |
1.75 |
237 |
Substance interaction with lung resident cell membrane components leading to atherosclerosis |
Ulla Vogel |
BY-SA |
- Substance interaction with the lung resident cell membrane components
|
| Under Development |
1.55 |
173 |
Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis |
Sabina Halappanavar |
All rights reserved |
- Substance interaction with the lung resident cell membrane components
|
| WPHA/WNT Endorsed |
1.32 |
534 |
Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress |
Xavier COUMOUL |
All rights reserved |
- Succinate dehydrogenase, inhibited
|
| |
|
474 |
Succinate dehydrogenase inactivation leads to cancer by promoting EMT |
Sylvie Bortoli |
BY-SA |
- Succinate dehydrogenase, inhibited
|
| Under Development |
1.106 |
546 |
Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms |
Sylvie Bortoli |
All rights reserved |
- Succinate dehydrogenase, inhibited
|
| |
|
457 |
Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine |
Simon Thomas |
Open for adoption |
- Succinate dehydrogenase, inhibited
|
- Insulin resistance, increased
| |
|
361 |
Sulfonylureareceptor binding leading to mortality |
Simon Schmid |
All rights reserved |
- Increase, Sulfonylurea receptor binding
|
| Under Development |
1.94 |
504 |
SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level |
Ana-Andreea Cioca |
All rights reserved |
- Inhibition of Sulfotransferase E1 (SULT1E1)
|
| |
|
85 |
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
|
- Decrease, Number of worker bees
- Death/Failure, Colony
| |
1.29 |
84 |
Suppression of immune system contributes to impaired development and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
|
- Decrease, Number of worker bees
- impaired, Hive thermoregulation
- Death/Failure, Colony
| |
1.29 |
41 |
Sustained AhR Activation leading to Rodent Liver Tumours |
Undefined |
BY-SA |
- Activation, Long term AHR receptor driven direct and indirect gene expression changes
|
- Formation, Hepatocellular and Bile duct tumors
| Under Review |
1.7 |
304 |
TBX1 inhibition leading to congenital cardiac conotruncal anomalies |
Jinsoo Lee |
All rights reserved |
|
- Anomalies, Congenital cardiac conotruncal
| |
|
375 |
test AOP |
Kevin Crofton |
BY-SA |
|
| |
|
511 |
The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects |
Yanhong Wei |
All rights reserved |
- Increase, Reactive Oxygen Species
|
- Increase, Vascular disrupting effects
| |
|
463 |
The AOP framwork on silica nanopariticles induced hepatoxicity |
Tianyu Li |
BY-SA |
|
| |
|
485 |
Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition |
Eliska Kuchovska |
BY-SA |
- Antagonism, Thyroid Receptor
|
- Cognitive function, decreased
| |
|
402 |
Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain |
Katherine (Katie) O'Shaughnessy |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Periventricular heterotopia formation
- Increase, seizure
| |
|
300 |
Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Kevin Crofton |
BY-SA |
- Antagonism, Thyroid Receptor
|
- Cognitive function, decreased
| Under Development |
1.84 |
175 |
Thyroperoxidase inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Altered, Amphibian metamorphosis
| |
1.29 |
365 |
Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning |
Lucia Vergauwen |
All rights reserved |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| Under Development |
1.35 |
363 |
Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure |
Lucia Vergauwen |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| Under Review |
1.35 |
364 |
Thyroperoxidase inhibition leading to altered visual function via decreased eye size |
Lucia Vergauwen |
All rights reserved |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| Under Development |
1.35 |
159 |
Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
347 |
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis |
Seokjoo Yoon |
BY-SA |
- Toll-like receptor 4 activation
- Inactivation of PPARγ
|
| |
|
316 |
Trypsin inhibition leading to pancreatic acinar cell tumors |
Shigeru Hisada |
BY-SA |
|
- Pancreatic acinar cell tumors
| Under Development |
1.60 |
189 |
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
|
- Altered, Amphibian metamorphosis
| |
1.29 |
190 |
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
|
- Altered, Amphibian metamorphosis
| |
1.29 |
191 |
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
|
- Altered, Amphibian metamorphosis
| |
1.29 |
263 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| WPHA/WNT Endorsed |
1.92 |
264 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
266 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
267 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
265 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
268 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
487 |
Unknown MIE altering cholesterol metabolism leading to decreased cognition |
Eliska Kuchovska |
BY-SA |
|
- Cognitive function, decreased
| |
|
186 |
unknown MIE leading to renal failure and mortality |
Kellie Fay |
BY-SA |
|
| |
1.29 |
123 |
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription |
Dalma Martinovic-Weigelt |
BY-SA |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
| |
1.29 |
8 |
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Katie Paul Friedman |
Open for adoption |
- Activation, Pregnane-X receptor, NR1l2
|
| Under Development |
1.9 |
121 |
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) |
Charles Wood |
BY-SA |
- Increase, Urinary bladder calculi
|
- Increase, Adenomas/carcinomas (urothelial)
| |
1.29 |
471 |
Various neuronal effects induced by elavl3, sox10, and mbp |
Donggon Yoo |
BY-SA |
- Increase, CNS Neural cell death
|
- impaired, Learning and memory
- Encephalitis
- Parkinsonian motor deficits
- Increase, seizure
- Increased, epilepsy
- Increase, Mortality
- Inhibition, Feeding
| |
|
180 |
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure |
Carlie LaLone |
BY-SA |
|
| |
1.29 |
179 |
Varroa mite infestation increases virus levels leading to colony loss/failure |
Carlie LaLone |
BY-SA |
|
| |
1.29 |
531 |
VEGFR inhibition leading to Keratinocyte differentiation-associate Hand-foot skin reaction |
Hui Li |
All rights reserved |
|
| |
|
385 |
Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation |
Julija Filipovska |
BY-SA |
|
| |
|
196 |
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation |
Jeanelle Martinez |
BY-SA |
- TRPA1 activation, TRPA1 Receptor
|
- Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
- Irritation of nasal mucosa inducing sneeze reflex
- Increased Respiratory irritability and Chronic Cough,
| |
|
182 |
Weather event contributes abnormal foraging leading to colony loss/failure |
Carlie LaLone |
BY-SA |
|
| |
1.29 |
181 |
Weather event contributes to colony loss/failure |
Carlie LaLone |
BY-SA |
|
| |
1.29 |
73 |
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity |
Undefined |
BY-SA |
- Inhibition, Inhibition of Dopamine-beta-hydroxylase
|
- Decreased, Decreased fecundity
| |
1.29 |
280 |
α-diketone-induced bronchiolitis obliterans |
Marvin Martens |
BY-SA |
- Interaction of α-diketones with arginine residues
|
| |
|