API
With OECD status With SAAOP status Recent AOPs

AOPs

ID Title Point of Contact Author Status SAAOP Status MIE AO OECD Status OECD Project
450 Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality SAROJ AMAR Under development: Not open for comment. Do not cite
  • Acetylcholinesterase (AchE) Inhibition
  • Sensory axonal peripheral neuropathy
  • Increased Mortality
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron Open for comment. Do not cite Included in OECD Work Plan
  • Binding to (interferes with) topoisomerase II enzyme
  • Infant leukaemia
WPHA/WNT Endorsed 1.53
389 Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen Under development: Not open for comment. Do not cite
  • Increase, Oxygen-evolving complex damage
  • Decrease, Reproduction
  • Decrease, Population growth rate
423 Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Fei Li Under development: Not open for comment. Do not cite
  • Activation, PARP1
  • ROS formation
  • Apoptotic cell death
98 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh Under Development: Contributions and Comments Welcome
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increased, predation
 1.29
97 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increase, predation
  • Decrease, Population growth rate
 1.29
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increased, Population
 1.29
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Decreased, Reproductive Success
  • Decrease, Population growth rate
 1.29
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increased, Reproductive Success
  • Increased, Population
 1.29
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • 5α-reductase, inhibition
  • decrease, male anogenital distance
Under Development 1.90
429 A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants Erwin L Roggen Under development: Not open for comment. Do not cite
  • Memory Loss
82 Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development
  • impaired, Larval development
  • Death/Failure, Colony
 1.29
385 ACE2 binding to viral S-protein leading to microvascular disfunction via ACE2 dysregulation Julija Filipovska Under development: Not open for comment. Do not cite
  • Binding to ACE2
427 ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. Evangelos-Panagiotis Daskalopoulos Under development: Not open for comment. Do not cite
  • Binding to ACE2
  • Heart failure
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Acetylcholinesterase (AchE) Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
Under Development 1.3
312 Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan Under development: Not open for comment. Do not cite
  • Acetylcholinesterase (AchE) Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
281 Acetylcholinesterase Inhibition Leading to Neurodegeneration Karen Watanabe Under development: Not open for comment. Do not cite
  • Acetylcholinesterase (AchE) Inhibition
  • N/A, Neurodegeneration
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi Under development: Not open for comment. Do not cite Under Development
  • Reproductive failure
462 Activation of reactive oxygen species leading the atherosclerosis Hiromi Ohara Under development: Not open for comment. Do not cite
439 Activation of the AhR leading to breast cancer Louise Benoit Under Development: Contributions and Comments Welcome
  • Activation, AhR
  • N/A, Breast Cancer
452 Adverse outcome pathway of PM-induced respiratory toxicity li qing Under development: Not open for comment. Do not cite
  • Non-coding RNA expression profile alteration
  • Chronic obstructive pulmonary disease
282 Adverse outcome pathway on photochemical toxicity initiated by light exposure Satomi Onoue Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • ROS generation from photoactivated chemicals
  • Inflamatory events in light-exposed tissues
EAGMST Under Review 1.49
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon Open for citation & comment Included in OECD Work Plan
  • Formation, Pro-mutagenic DNA Adducts
  • Tumorigenesis, Hepatocellular carcinoma
EAGMST Under Review 1.8
458 AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Under development: Not open for comment. Do not cite
459 AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Under development: Not open for comment. Do not cite
57 AhR activation leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development
  • Activation, AhR
  • Accumulation, Liver lipid
 1.29
151 AhR activation leading to preeclampsia Sabrina Tait Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Activation, AhR
  • increase, Preeclampsia
Under Development 1.42
62 AKT2 activation leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development
  • systemic inflammation leading to hepatic steatosis
  • Increased, Liver Steatosis
 1.29
465 Alcohol dehydrogenase leading to reproductive dysfunction Donggon Yoo Under development: Not open for comment. Do not cite
  • Increase, Alcohol dehydrogenase
443 Alcohol Induced DNA damage and mutations leading to Metastatic Breast Cancer Usha Adiga Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Increased, DNA damage and mutation
  • metastatic breast cancer
Under Development 1.103
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk Open for citation & comment Included in OECD Work Plan
  • Alkylation, DNA
  • Increase, Heritable mutations in offspring
WPHA/WNT Endorsed 1.11
139 Alkylation of DNA leading to cancer 1 Carole Yauk Open for adoption Under Development
  • Alkylation, DNA
  • Increase, Cancer
322 Alkylation of DNA leading to reduced sperm count Carole Yauk Under development: Not open for comment. Do not cite
  • Alkylation, DNA
  • Reduce, Sperm count
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Tammy Stoker Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Antgonism of NE receptor
  • Decreased, Decreased fecundity
1.29
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Increased, Binding of chemicals to 2u (serum)
  • Increase, Adenomas/carcinomas (renal tubular)
 1.29
104 Altered ion channel activity leading impaired heart function Kevin Dreher Under Development: Contributions and Comments Welcome Under Development
  • impaired, ion channels
  • Increased Mortality
 1.29
345 Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen Under development: Not open for comment. Do not cite
  • Antagonism, Androgen receptor
  • Decreased fertility, Reduced number of oocytes ovulated
344 Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite
  • Antagonism, Androgen receptor
  • Nipple retention in male offspring, increased
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Antagonism, Androgen receptor
  • decrease, male anogenital distance
Under Development 1.90
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Open for adoption Included in OECD Work Plan
  • Activation, Androgen receptor
  • Increase, hepatocellular adenomas and carcinomas
Under Development 1.26
376 Androgen receptor agonism leading to male-biased sex ratio Dan Villeneuve Open for citation & comment
  • Agonism, Androgen receptor
  • Decrease, Population growth rate
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve Open for citation & comment Included in OECD Work Plan
  • Agonism, Androgen receptor
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.12
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel Open for adoption Under Development
  • N/A, Androgen receptor, Antagonism
  • N/A, Impairment of reproductive capacity
372 Androgen receptor antagonism leading to testicular cancer Chander K. Negi Under development: Not open for comment. Do not cite
  • Antagonism, Androgen receptor
  • Testicular Cancer
382 Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Young Jun Kim Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
  • Lung fibrosis
Under Development 1.96
460 Antagonism of Smoothened receptor leading to orofacial clefting Jacob Reynolds Under development: Not open for comment. Do not cite
  • Antagonism, Smoothened receptor
  • Ororofacial clefting
6 Antagonist binding to PPARα leading to body-weight loss Kurt A. Gust Open for citation & comment Included in OECD Work Plan
  • Binding of antagonist, PPAR alpha
  • Decreased, Body Weight
WPHA/WNT Endorsed 2.3
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Increased, Adenomas/carcinomas (mammary)
 1.29
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Barnett Rattner Not under active development Included in OECD Work Plan
  • Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
  • Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
  • Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
  • Impaired recruitment , Population trajectory
Under Development 1.31
165 Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Promotion, ovarian adenomas
  • Promotion, ovarian granular cell tumors
 1.29
393 AOP for thyroid disorder caused by triphenyl phosphate Fei Li Under development: Not open for comment. Do not cite
  • Increased, Hepatic thyroid hormone uptake/transport
335 AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza Under development: Not open for comment. Do not cite
  • Mitochondrial impairment
  • Urothelial Tumor
205 AOP from chemical insult to cell death Mathieu Vinken Open for comment. Do not cite Under Development
  • Decompartmentalization
  • Direct mitochondrial inhibition
  • narcosis
  • Apoptosis
  • Necrosis
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard Open for citation & comment Included in OECD Work Plan
  • reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
  • impaired, Fertility
  • irregularities, ovarian cycle
EAGMST Under Review 1.21
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Tammy Stoker Under Development: Contributions and Comments Welcome Under Development
  • Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
  • Decreased fertility, Reduced number of oocytes ovulated
1.29
25 Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan
  • Inhibition, Aromatase
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.12
346 Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez Under Development: Contributions and Comments Welcome
  • Inhibition, Aromatase
  • Decrease, Population growth rate
456 Aryl hydrocarbon receptor activation leading to early life stage mortality via cardiovascular toxicity Prarthana Shankar Under development: Not open for comment. Do not cite
  • Activation, AhR
  • Increase, Early Life Stage Mortality
455 Aryl hydrocarbon receptor activation leading to early life stage mortality via impeded craniofacial development Prarthana Shankar Under development: Not open for comment. Do not cite
  • Activation, AhR
  • Increase, Early Life Stage Mortality
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker Open for citation & comment Included in OECD Work Plan
  • Activation, AhR
WPHA/WNT Endorsed 1.27
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat Open for citation & comment Included in OECD Work Plan
  • Activation, AhR
  • Increase, Early Life Stage Mortality
WPHA/WNT Endorsed 1.7
418 Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway Dianke Yu Under development: Not open for comment. Do not cite
419 Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Dianke Yu Under development: Not open for comment. Do not cite
  • Decrease, Lung function
417 Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway Dianke Yu Under development: Not open for comment. Do not cite
  • Activation, AhR
  • Lung cancer
416 Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway Dianke Yu Under development: Not open for comment. Do not cite
  • Activation, AhR
  • Lung cancer
420 Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Dianke Yu Under development: Not open for comment. Do not cite
  • Activation, AhR
415 Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway Dianke Yu Under development: Not open for comment. Do not cite
  • Activation, AhR
  • Lung fibrosis
414 Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway Dianke Yu Under development: Not open for comment. Do not cite
  • Activation, AhR
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat Open for citation & comment Included in OECD Work Plan
  • Activation, AhR
  • Uroporphyria
WPHA/WNT Endorsed 1.7
96 Axonal sodium channel modulation leading to acute mortality Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • modulation, sodium channel
  • Increased Mortality
 1.29
164 Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Activation, beta-2 adrenergic receptor
  • Promotion, mesovarian leiomyomas
 1.29
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price Open for citation & comment Included in OECD Work Plan
  • Binding of agonist, Ionotropic glutamate receptors
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.23
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding, Thiol/seleno-proteins involved in protection against oxidative stress
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.13
284 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois Under development: Not open for comment. Do not cite
  • Binding, Thiol/seleno-proteins involved in protection against oxidative stress
  • Chronic kidney disease
428 Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis Laure-Alix Clerbaux Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
Under Development 1.96
374 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Anna Price Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
  • Encephalitis
Under Development 1.96
395 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) Magda Sachana Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
  • Cerebrovascular disease (stroke)
Under Development 1.96
422 Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption Laure-Alix Clerbaux Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
Under Development 1.96
468 Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) Laure-Alix Clerbaux Under development: Not open for comment. Do not cite
  • Binding to ACE2
  • Increase, the risk of acute respiratory failure
430 Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation Sally Mayasich Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
  • Viral infection and host-to-host transmission, proliferated
Under Development 1.96
320 Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim Open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
  • Increased Mortality
Under Development 1.96
381 Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Young Jun Kim Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
  • dysgeusia
Under Development 1.96
319 Binding to ACE2 leading to lung fibrosis Young Jun Kim Open for comment. Do not cite Included in OECD Work Plan
  • Induced dysregulation of ACE2
  • Lung fibrosis
Under Development 1.96
379 Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation Shihori Tanabe Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
  • Thrombosis and Disseminated Intravascular Coagulation
Under Development 1.96
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Yasuharu Otsubo Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to estrogen receptor (ER)-α in immune cells
  • Exacerbation of systemic lupus erythematosus (SLE)
Under Development 1.73
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Ping Gong Open for citation & comment Included in OECD Work Plan
  • Binding at picrotoxin site, iGABAR chloride channel
  • Occurrence, Epileptic seizure
WPHA/WNT Endorsed 1.15
397 Bulky DNA adducts leading to mutations Carole Yauk Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Bulky DNA adducts, increase
  • Increase, Mutations
Under Development 1.11
464 Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits Julia Meerman Under development: Not open for comment. Do not cite
  • Activation of metabotropic glutamate receptor
  • Inositol triphosphate receptor activation
  • Overactivation, NMDARs
  • Inhibition GABAA receptor
  • Parkinsonian motor deficits
26 Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon Open for adoption Under Development
  • Inhibition, Ca++ ATPase
  • Increased, Oxidative damage
449 Ceramide synthase inhibition leading to neural tube defects Lola Bajard Open for citation & comment
  • Inhibition of Ceramide Synthase
  • Neural tube defects
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti Open for citation & comment Included in OECD Work Plan
  • Binding, Tubulin
  • Increase, Aneuploid offspring
EAGMST Under Review 1.11
360 Chitin synthase 1 inhibition leading to mortality Simon Schmid Open for citation & comment Included in OECD Work Plan
  • Inhibition, Chitin synthase 1
  • Increase, Mortality
WPHA/WNT Endorsed 1.94
358 Chitinase inhibition leading to mortality Simon Schmid Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibition, Chitinase
  • Increase, Mortality
Under Development 1.94
359 Chitobiase inhibition leading to mortality Simon Schmid Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibition, Chitobiase
  • Increase, Mortality
Under Development 1.94
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibition, Bile Salt Export Pump (ABCB11)
  • Cholestasis, Pathology
Under Development 1.19
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price Open for citation & comment Included in OECD Work Plan
  • Binding of antagonist, NMDA receptors
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.22
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet Open for citation & comment Included in OECD Work Plan
  • Binding of antagonist, NMDA receptors
  • N/A, Neurodegeneration
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.13
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Increase, Cytotoxicity (hepatocytes)
  • Increase, hepatocellular adenomas and carcinomas
 1.29
171 Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Increased, mesotheliomas
 1.29
403 combined unhealthy lifestyle factors leading to metabolic syndrome Gillina Bezemer Under development: Not open for comment. Do not cite
367 Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite
  • Binding, Thyroid binding globulin in serum
  • Altered, Amphibian metamorphosis
366 Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite
  • Binding, Transthyretin in serum
  • Altered, Amphibian metamorphosis
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser Open for citation & comment Included in OECD Work Plan
  • Activation, Constitutive androstane receptor
  • Increase, hepatocellular adenomas and carcinomas
EAGMST Under Review 1.17
39 Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins leads to Sensitisation (Sensitization) of the Respiratory Tract Kristie Sullivan Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Covalent Binding, Protein
  • Increase, Allergic Respiratory Hypersensitivity Response
Under Development 1.20
40 Covalent Protein binding leading to Skin Sensitisation Sharon Munn Open for citation & comment Included in OECD Work Plan
  • Covalent Binding, Protein
  • sensitisation, skin
WPHA/WNT Endorsed 1.1
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Cyclooxygenase 1 activity
  • Increased Mortality
  • Decrease, Population growth rate
 1.29
28 Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Cyclooxygenase activity
  • N/A, Reproductive failure
 1.29
63 Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
 1.29
100 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
 1.29
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
 1.29
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
 1.29
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
 1.29
434 CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects Job Berkhout Under development: Not open for comment. Do not cite
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders Under development: Not open for comment. Do not cite
  • CYP2E1 Activation
  • Protein Adduct Formation
  • Neurodegeneration
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster Open for citation & comment Included in OECD Work Plan
  • Activation of Cyp2E1
  • Liver Cancer
WPHA/WNT Endorsed 1.24
368 Cytochrome oxidase inhibition leading to olfactory nasal lesions Katy Goyak Under development: Not open for comment. Do not cite
  • Inhibition, cytochrome oxidase
  • Increase, Site of Contact Nasal Tumors
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Increase, Cytotoxicity (club cells)
  • Increase, Adenomas/carcinomas (bronchioloalveolar)
 1.29
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Increase, Cytotoxicity (tubular epithelial cells)
  • Increase, Adenomas/carcinomas (renal tubular)
 1.29
86 Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development
  • impaired, Larval development
  • Death/Failure, Colony
 1.29
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Decreased, Androgen receptor activity
  • Increase, Leydig cell tumors
 1.29
392 Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation Penny Nymark Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Fibrinolysis, decreased
  • Bradykinin system, hyperactivated
  • Hyperinflammation
Under Development 1.96
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • decrease, male anogenital distance
Under Development 1.90
158 Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Inhibition, Deiodinase 1
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
157 Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Inhibition, Deiodinase 1
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
156 Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Inhibition, Deiodinase 2
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
155 Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Inhibition, Deiodinase 2
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
432 Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Dag Anders Brede Under development: Not open for comment. Do not cite
  • Deposition of Energy
  • Acute Myeloid Leukemia
272 Deposition of energy leading to lung cancer Vinita Chauhan Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Deposition of Energy
  • Increase, lung cancer
EAGMST Approved 1.56
299 Deposition of energy leading to population decline via DNA oxidation and follicular atresia You Song Under development: Not open for comment. Do not cite Under Development
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
311 Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis You Song Under development: Not open for comment. Do not cite
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
216 Deposition of energy leading to population decline via DNA strand breaks and follicular atresia Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
238 Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis Knut Erik Tollefsen Under development: Not open for comment. Do not cite
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
470 Deposition of energy leads to vascular remodeling Vinita Chauhan Under development: Not open for comment. Do not cite
  • Deposition of Energy
  • Occurrence, Vascular Remodeling
388 Deposition of ionising energy leading to population decline via programmed cell death Knut Erik Tollefsen Under development: Not open for comment. Do not cite
  • Deposition of Energy
  • Decrease, Reproduction
  • Decrease, Population growth rate
387 Deposition of ionising energy leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen Under development: Not open for comment. Do not cite
  • Deposition of Energy
  • Decrease, Reproduction
  • Decrease, Population growth rate
461 Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis Knut Erik Tollefsen Under development: Not open for comment. Do not cite
435 Deposition of ionising energy leads to population decline via pollen abnormal Li Xie Under development: Not open for comment. Do not cite
  • Deposition of Energy
  • Decrease, Reproduction
  • Decreased, Population trajectory
386 Deposition of ionizing energy leads to leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen Under development: Not open for comment. Do not cite
  • Deposition of Energy
  • Decrease, Reproduction
  • Decrease, Population growth rate
396 Deposition of ionizing energy leads to population decline via impaired meiosis Erica Maremonti Under development: Not open for comment. Do not cite
  • Deposition of Ionizing Energy
  • Decrease of egg production and cummulative fecundity
  • Decrease, Reproduction
  • Decreased, Population size
43 Disruption of VEGFR Signaling Leading to Developmental Defects Tom Knudsen Open for citation & comment Included in OECD Work Plan
  • Inhibition, VegfR2
  • Increased, Developmental Defects
EAGMST Under Review 1.6
472 DNA adduct formation leading to kidney failure Manoe Janssen Under development: Not open for comment. Do not cite
240 DNA Adducts Leading to Liver Hemangiosarcoma Annie Jarabek Under development: Not open for comment. Do not cite Under Development
336 DNA methyltransferase inhibition leading to population decline (1) You Song Under Development: Contributions and Comments Welcome Under Development
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
337 DNA methyltransferase inhibition leading to population decline (2) You Song Under Development: Contributions and Comments Welcome Under Development
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
338 DNA methyltransferase inhibition leading to population decline (3) You Song Under Development: Contributions and Comments Welcome
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
339 DNA methyltransferase inhibition leading to population decline (4) You Song Under Development: Contributions and Comments Welcome Under Development
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
340 DNA methyltransferase inhibition leading to transgenerational effects (1) You Song Under Development: Contributions and Comments Welcome Under Development
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity (F3)
  • Decrease, Population growth rate
341 DNA methyltransferase inhibition leading to transgenerational effects (2) You Song Under Development: Contributions and Comments Welcome Under Development
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity (F3)
  • Decrease, Population growth rate
466 Doda decarboxylase leading to mortality Donggon Yoo Under development: Not open for comment. Do not cite
  • Decrease, Tyrosine
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Dual oxidase
  • Altered, Amphibian metamorphosis
 1.29
377 Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) Gillina Bezemer Under development: Not open for comment. Do not cite
  • Prolonged TLR9 activation
  • Multi Organ Failure involving Acute Respiratory Distress Syndrome
  • Increased Mortality
378 Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Gillina Bezemer Under development: Not open for comment. Do not cite
  • Toll Like Receptor (TLR) Dysregulation
167 Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • prepubertal increase, Estrogen receptor (ER) activity
  • Increased, adenosquamous carcinomas of endometrium
 1.29
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman Under development: Not open for comment. Do not cite Included in OECD Work Plan
Under Development 1.79
4 Ecdysone receptor agonism leading to incomplete ecdysis associated mortality Knut Erik Tollefsen Open for citation & comment Under Development
  • Increase, Ecdysone receptor agonism
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Activation, EGFR
  • Decrease, Lung function
Under Development 1.51
471 elavl3, sox10, mbp neurogene Donggon Yoo Under development: Not open for comment. Do not cite
269 Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild Under development: Not open for comment. Do not cite
270 Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild Under development: Not open for comment. Do not cite
310 Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering Under development: Not open for comment. Do not cite
  • Activation, AhR
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Endocytotic lysosomal uptake
  • N/A, Liver fibrosis
EAGMST Under Review 1.47
412 Endothelial cell dysfunction leading to thromboinflammation Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Thromboinflammation, Increased
Under Development 1.96
473 Energy deposition from internalized Ra-226 decay leads to altered ventilation behavior and slower growth in Lymnaea stagnalis due to apparent hypoxia from decreased hemocyanin oxygen binding capacity Danielle Beaton Under development: Not open for comment. Do not cite
  • Deposition of Energy
  • Decrease, Growth
  • Decreased, Reproductive Success
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Increase, Adenomas/carcinomas (follicular cell)
 1.29
72 Epigenetic modification of PPARG leading to adipogenesis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development
  • peroxisome proliferator activated receptor promoter demethylation
  • chronic high fat diet
  • obesity
 1.29
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Increase, Cytotoxicity (epithelial cells)
  • Increase, Papillomas/carcinomas (squamous cells)
 1.29
53 ER agonism leading to reduced survival due to renal failure Tom Hutchinson Under Development: Contributions and Comments Welcome Under Development
  • Agonism, Estrogen receptor
1.29
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Tom Hutchinson Under Development: Contributions and Comments Welcome Under Development
  • Agonism, Estrogen receptor
  • skewed, sex ratio
 1.29
199 ER mediated breast cancer AOP Molly M Morgan Under development: Not open for comment. Do not cite Under Development
146 Estrogen Receptor Activation and Female Precocious Puberty Jeff Welch Under Development: Contributions and Comments Welcome Under Development
1.29
200 Estrogen receptor activation leading to breast cancer Molly M Morgan Open for adoption Under Development
  • Activation, Estrogen receptor
  • N/A, Breast Cancer
29 Estrogen receptor agonism leading to reproductive dysfunction Tom Hutchinson Under Development: Contributions and Comments Welcome Under Development
  • Agonism, Estrogen receptor
  • Decrease, Population growth rate
  • Altered, Reproductive behaviour
  • Altered, Larval development
  • Impaired development of, Reproductive organs
 1.29
445 Estrogen Receptor Alpha Agonism leads to Impaired Reproduction John Hoang Under development: Not open for comment. Do not cite
  • Activation, estrogen receptor alpha
  • Impaired, Reproduction
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan
  • Antagonism, Estrogen receptor
  • Decrease, Population growth rate
EAGMST Under Review 1.12
95 Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
  • Reduced, survival
 1.29
327 Excessive reactive oxygen species production leading to mortality (1) You Song Under development: Not open for comment. Do not cite
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
328 Excessive reactive oxygen species production leading to mortality (2) You Song Under development: Not open for comment. Do not cite
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
329 Excessive reactive oxygen species production leading to mortality (3) You Song Under development: Not open for comment. Do not cite
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
330 Excessive reactive oxygen species production leading to mortality (4) You Song Under development: Not open for comment. Do not cite
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
331 Formation of DNA photoproducts leading to growth inhibition (1) You Song Under development: Not open for comment. Do not cite
  • Increase, Formation of DNA photoproducts
  • Increase, Mortality
332 Formation of DNA photoproducts leading to growth inhibition (2) You Song Under development: Not open for comment. Do not cite
333 Formation of DNA photoproducts leading to growth inhibition (3) You Song Under development: Not open for comment. Do not cite
409 Frustrated phagocytosis leads to malignant mesothelioma Penny Nymark Under development: Not open for comment. Do not cite
  • Frustrated phagocytosis
  • Increased, mesotheliomas
303 Frustrated phagocytosis-induced lung cancer Carole Seidel Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Frustrated phagocytosis
  • Lung cancer
Under Development 1.86
401 G protein-coupled estrogen receptor 1 (GPER) signal pathway in the endocrine disrupting effect Fei Li Under development: Not open for comment. Do not cite
  • protein-coupled estrogen receptor 1 (GPER) activation
  • N/A, Steatohepatisis
217 Gastric ulcer formation Lyle Burgoon Open for adoption Under Development
  • Inhibit, gastric ulcer formation
  • Activated, gastric ulcer formation
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Susan Laws Under Development: Contributions and Comments Welcome Under Development
  • Glucocorticoid Receptor Agonist, Activation
  • impaired, Fertility
 1.29
318 Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi Under Development: Contributions and Comments Welcome
  • Activation, Glucocorticoid Receptor
  • Increased, Liver Steatosis
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone Open for comment. Do not cite
  • Activation, Glucocorticoid Receptor
  • Increased, Disease susceptibility
 1.29
334 Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Alexander Cole Open for citation & comment
  • Activation, Glucocorticoid Receptor
  • Decrease, Population growth rate
113 Glutamate-gated chloride channel activation leading to acute mortality Helen Poynton Under Development: Contributions and Comments Welcome Under Development
  • Activation, Glutamate-gated chloride channel
  • Increased Mortality
  • Decreased, population 1
 1.29
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
  • Activation, Glutamate-gated chloride channels
  • Increased Mortality
168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Increased, Adenomas/carcinomas (mammary)
 1.29
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Increased, adenomas (pituitary)
 1.29
410 GSK3beta inactivation leading to increased mortality via defects in developing inner ear Vid Modic Open for citation & comment
  • GSK3beta inactivation
  • Increased Mortality
  • Decrease, Population growth rate
211 Handbook development AOP Dan Villeneuve Under Development: Contributions and Comments Welcome Under Development
1.29
229 Helicobacter pylori to gastric ulcer Lyle Burgoon Open for adoption Under Development
  • Helicobacter pylori infection
  • Activated, gastric ulcer formation
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development
  • Activation, Hepatic nuclear receptor(s)
  • Altered, Amphibian metamorphosis
 1.29
433 hERG inhibition leading to cardiac toxicity Egemen Bilgin Under development: Not open for comment. Do not cite
  • Binding to hERG channel
  • hERG channel biogenesis interference
  • Sudden cardiac death
99 Histamine (H2) receptor antagonism leading to reduced survival Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • Antagonism, Histamine Receptor (H2)
  • Decreased, survival
  • Increased, predation
 1.29
212 Histone deacetylase inhibition leading to testicular atrophy Shihori Tanabe Open for citation & comment Included in OECD Work Plan
  • Histone deacetylase inhibition
  • Testicular atrophy
WPHA/WNT Endorsed 1.52
274 Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens Under Development: Contributions and Comments Welcome
  • Histone deacetylase inhibition
  • Facial cartilage structures are reduced in size and morphologically distorted
275 Histone deacetylase inhibition leads to neural tube defects Marvin Martens Under Development: Contributions and Comments Welcome
  • Histone deacetylase inhibition
  • Neural tube defects
124 HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, HMG-CoA reductase
  • Decrease, Fertility
 1.29
59 HNF4alpha suppression leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development
  • Suppression, HNF4alpha
1.29
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
  • Increase, Papillomas/carcinomas (squamous cells)
 1.29
384 Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Young Jun Kim Under development: Not open for comment. Do not cite
  • Hyperactivation of ACE/Ang-II/AT1R axis
  • Chronic kidney disease
440 Hypothalamic estrogen receptors inhibition leading to ovarian cancer Kalyan Gayen Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Suppression, Estrogen receptor (ER) activity
  • Promotion, ovarian adenomas
  • Promotion, ovarian granular cell tumors
Under Development 1.104
278 IKK complex inhibition leading to liver injury Nanette Vrijenhoek Under development: Not open for comment. Do not cite
  • Inhibition, IKK complex
  • Necrotic Tissue
  • Liver Injury
408 Imbalance in redox homeostasis leading to structural damage to tissues Fei Li Under development: Not open for comment. Do not cite
362 Immune mediated hepatitis Jung-Hwa Oh Under development: Not open for comment. Do not cite
  • benzoquinone imine and acylglucuronide metabolites
  • Immune mediated hepatitis
277 Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response Takao Ashikaga Open for citation & comment Included in OECD Work Plan
  • Impaired IL-1R1 signaling in T cell
  • Impairment of TDAR
EAGMST Under Review 1.48
400 Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males Terje Svingen Under development: Not open for comment. Do not cite
  • Increased (ectopic) all-trans retinoic acid concentration
  • Reduce, Sperm count
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Increase, DNA damage
  • Increase, Mutations
  • Increased, Ductal Hyperplasia
  • N/A, Breast Cancer
Under Development 1.80
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Increase, Dopaminergic activity
  • Increase, Endometrial adenocarcinomas
 1.29
81 Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development
  • Decrease, Number of worker bees
  • Death/Failure, Colony
 1.29
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Increase in reactive oxygen and nitrogen species (RONS)
  • Increase, DNA damage
  • Increase, Mutations
  • Increased, Ductal Hyperplasia
  • N/A, Breast Cancer
Under Development 1.80
431 Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) Qi Wang Under Development: Contributions and Comments Welcome
  • Increase, TNF
  • Gestational diabetes mellitus
298 Increases in cellular reactive oxygen species (Chronic reactive oxygen species) leading to human treatment-resistant gastric cancer Shihori Tanabe Open for comment. Do not cite Included in OECD Work Plan
  • Increases in cellular reactive oxygen species
  • Chronic reactive oxygen species
  • Treatment-resistant gastric cancer
EAGMST Under Review 1.58
349 Inhibition of 11β-hydroxylase leading to decresed population trajectory Young Jun Kim Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • 11β-hydroxylase inhibition
  • Decrease, Population growth rate
Under Development 1.93
348 Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory Young Jun Kim Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibition of 11β-HSD
  • Decrease, Population growth rate
Under Development 1.93
288 Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET Open for citation & comment
  • Inhibition, Cytochrome P450 enzyme (CYP17A1) activity
  • Malformation, cryptorchidism - maldescended testis
289 Inhibition of 5α-reductase leading to impaired fecundity in female fish Young Jun Kim Open for citation & comment Included in OECD Work Plan
  • 5α-reductase, inhibition
  • Decrease, Population growth rate
Under Development 1.81
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, 5α-reductase activity
  • Increase, Leydig cell tumors
 1.29
398 Inhibition of ALDH1A (RALDH) causing reduced all-trans retinoic acid levels leading to impaired fertility, females Terje Svingen Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibition of ALDH1A (RALDH)
  • impaired, Fertility
Under Development 1.97
383 Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Young Jun Kim Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Induced dysregulation of ACE2
  • N/A, Liver fibrosis
Under Development 1.96
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Takumi Ohishi Open for comment. Do not cite Included in OECD Work Plan
  • Inhibition, Calcineurin Activity
  • Impairment, T-cell dependent antibody response
WPHA/WNT Endorsed 1.38
276 Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens Under development: Not open for comment. Do not cite
  • Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
  • Chemical induced Fanconi syndrome
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière Not under active development Under Development
  • CYP7B activity, inhibition
  • Decrease, Population growth rate
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière Not under active development Under Development
  • CYP7B activity, inhibition
  • Decrease, Population growth rate
301 Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim Under development: Not open for comment. Do not cite
  • Inhibition of cystathionine beta-synthase
  • Impaired,anterior-posterior axis development
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon Open for adoption Under Development
  • Inhibition, Fatty Acid Beta Oxidation
  • N/A, Steatohepatisis
399 Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) Vid Modic Open for citation & comment
  • Inhibition of Fyna
  • Increased Mortality
  • Decrease, Population growth rate
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Michelle Embry Not under active development Under Development
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Na+/I- symporter (NIS)
  • Increase, Adenomas/carcinomas (follicular cell)
 1.29
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Yasuhiro Yoshida Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibition of JAK3
  • Impairment of T-cell dependent antibody response
Under Development 1.74
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz Open for adoption
  • Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
  • Growth, reduction
  • Decreased, survival
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)
  • Occurrence, Kidney toxicity
Under Development 1.43
437 Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity Baki Sadi Under development: Not open for comment. Do not cite
  • Inhibition, Mitochondrial Electron Transport Chain Complexes
  • Occurrence, Kidney toxicity
285 Inhibition of N-linked glycosylation leads to liver injury Marvin Martens Under development: Not open for comment. Do not cite
  • Inhibition of N-linked glycosylation
  • Liver Injury
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price Open for citation & comment Included in OECD Work Plan
  • Inhibition, Na+/I- symporter (NIS)
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.28
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
  • Increase, hepatocellular adenomas and carcinomas
 1.29
436 Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries Gina Mennen Open for comment. Do not cite
  • Inhibition of ALDH1A (RALDH)
  • transposition of the great arteries
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Young Jun Kim Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Retinaldehyde dehydrogenase inhibition
  • Decrease, Population growth rate
Under Development 1.77
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron Open for citation & comment Included in OECD Work Plan
  • Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
  • Parkinsonian motor deficits
WPHA/WNT Endorsed 1.33
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Thyroperoxidase, Inhibition
  • Increase, Adenomas/carcinomas (follicular cell)
 1.29
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park Open for comment. Do not cite Included in OECD Work Plan
  • Thyroperoxidase, Inhibition
  • Reduction, Cumulative fecundity and spawning
Under Development 1.59
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton Open for citation & comment Included in OECD Work Plan
  • Thyroperoxidase, Inhibition
  • Cognitive Function, Decreased
WPHA/WNT Endorsed 1.10
292 Inhibition of tyrosinase leads to decreased population in fish Young Jun Kim Open for citation & comment Included in OECD Work Plan
  • Inhibition of tyrosinase
  • Decrease, Population growth rate
Under Development 1.78
442 Inhibition of voltage gate sodium channels leading to impairment in learning and memory during development Andrea Terron Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibit, voltage-gated sodium channel
  • Impairment, Learning and memory
Under Development 1.91
451 Interaction with lung resident cell membrane components leads to lung cancer Penny Nymark Under development: Not open for comment. Do not cite
  • Substance interaction with the lung resident cell membrane components
  • Lung cancer
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Kristie Sullivan Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Binding, Transthyretin in serum
  • Cognitive Function, Decreased
Under Development 1.41
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Justin Teeguarden Open for citation & comment Included in OECD Work Plan
  • Decrease, Intracellular pH
  • Increase, Site of Contact Nasal Tumors
EAGMST Under Review 2.7
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Iodotyrosine deiodinase (IYD)
  • Altered, Amphibian metamorphosis
 1.29
444 Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability Deborah Oughton Under development: Not open for comment. Do not cite
  • Deposition of Energy
  • Increase in reactive oxygen and nitrogen species (RONS)
  • Increase, DNA damage
  • Decrease, Population growth rate
441 Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation Olivier ARMANT Under development: Not open for comment. Do not cite
  • Deposition of Energy
  • Increase risk, microcephaly
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
  • Activation, ionotropic GABA Receptor chloride channel
  • Increased Mortality
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi Under development: Not open for comment. Do not cite Under Development
  • Reproductive failure
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Knut Erik Tollefsen Under Development: Contributions and Comments Welcome Under Development
  • Activation, Juvenile hormone receptor
  • Increased, Male offspring
  • Decline, Population
  • Alteration, Food-web structures
128 Kidney dysfunction by decreased thyroid hormone Jung-Hwa Oh Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Thyroid hormone synthesis, Decreased
  • Occurrence, Kidney toxicity
Under Development 1.40
447 Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways Yann GUEGUEN Under development: Not open for comment. Do not cite
  • Increased, Kidney Failure
33 Kidney toxicity induced by activation of 5HT2C Kevin Crofton Open for adoption Under Development
  • Activation, 5HT2c
  • Increased, Kidney Failure
467 Knickkopf leading to mortality Donggon Yoo Under development: Not open for comment. Do not cite
  • Decrease, 20-hydroxyecdysone
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Blockade, L-Type Calcium Channels
  • Heart failure
Under Development 1.45
283 L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite Included in OECD Work Plan
Under Development 1.45
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite Included in OECD Work Plan
Under Development 1.45
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens Under development: Not open for comment. Do not cite
  • Activation, Latent Transforming Growth Factor Beta 1
  • Pulmonary fibrosis
302 Lung surfactant function inhibition leading to decreased lung function Jorid Birkelund Sørli Open for comment. Do not cite Included in OECD Work Plan
  • Inhibition of lung surfactant function
  • Decrease, Lung function
Under Development 1.87
309 Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim Under Development: Contributions and Comments Welcome
  • Antagonism,LH receptor
  • Decline, Population trajectory
34 LXR activation leading to hepatic steatosis Marina Goumenou Not under active development Under Development
  • Activation, LXR
  • peroxisome proliferator activated receptor promoter demethylation
  • N/A, Liver Steatosis
222 Mental stress to agitation Lyle Burgoon Open for adoption Under Development
  • Increased, glucocorticoid receptor activity
  • Increased, agitation
221 Mental stress to depression Lyle Burgoon Open for adoption Under Development
  • Increased, glucocorticoid receptor activity
  • Increased, depression
404 Metabolic Syndrome leading to Toll Like Receptor dysregulation Gillina Bezemer Under development: Not open for comment. Do not cite
279 Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens Under development: Not open for comment. Do not cite
  • Binding of microtubule stabilizing agents (MSA) to microtubules
  • Sensory axonal peripheral neuropathy
290 Mitochondrial ATP synthase antagonism leading to growth inhibition (1) You Song Under development: Not open for comment. Do not cite Under Development
  • Increase, Mitochondrial ATP synthase antagonism
  • Decrease, Growth
291 Mitochondrial ATP synthase antagonism leading to growth inhibition (2) You Song Under development: Not open for comment. Do not cite Under Development
  • Increase, Mitochondrial ATP synthase antagonism
  • Decrease, Growth
286 Mitochondrial complex III antagonism leading to growth inhibition (1) You Song Under development: Not open for comment. Do not cite Under Development
  • Increase, Mitochondrial complex III antagonism
  • Decrease, Growth
287 Mitochondrial complex III antagonism leading to growth inhibition (2) You Song Under development: Not open for comment. Do not cite Under Development
  • Increase, Mitochondrial complex III antagonism
  • Decrease, Growth
273 Mitochondrial complex inhibition leading to liver injury Wanda van der Stel Under development: Not open for comment. Do not cite
  • Increase, Mitochondrial complex III antagonism
  • Mitochondrial Complex IV inhibition
  • Mitochondrial Complex V inhibition
  • Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
  • Inhibition, NADH-ubiquinone oxidoreductase (complex I)
  • Binding of inhibitor to mitochondrial complex III
  • Binding of inhibitor to mitochondrial complex IV
  • Binding of inhibitor to mitochondrial complex V
  • Necrotic Tissue
  • Liver Injury
373 Mitochondrial dysfunction to metabolic diseases Chander K. Negi Under Development: Contributions and Comments Welcome
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development
  • Decreased testosterone by the fetal Leydig cells, Increased corticosterone
  • Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
  • Decreased sperm quantity / quality in the adult, Decreased fertility
1.29
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development
  • Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
  • Decreased sperm quantity / quality in the adult, Decreased fertility
1.29
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development
  • Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol
  • Decreased Cholesterol, Decreased Uptake of Lipoproteins
  • Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
  • Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
 1.29
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development
  • Decreased testosterone by the fetal Leydig cells, Increased estradiol
  • Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists
  • Decreased sperm quantity / quality in the adult, Decreased fertility
1.29
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development
  • Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
  • Decreased sperm quantity or quality in the adult, Decreased fertility
1.29
74 Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development
  • Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
  • Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
 1.29
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development
  • Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
  • Decreased sperm quantity or quality in the adult, Decreased fertility
1.29
215 Molecular events lead to epilepsy Lyle Burgoon Open for adoption Under Development
  • Increase, seizure
  • Increased, hippocampal hyperdepolarization
  • Increased, epilepsy
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Timothy Allen Not under active development Under Development
  • Mu Opioid Receptor Agonism
  • Analgesia
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen Not under active development Under Development
  • Mu Opioid Receptor Agonism
  • Analgesia
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Jinhee Choi Under development: Not open for comment. Do not cite Under Development
  • Activation, NADPH Oxidase
  • Reproductive failure
35 Narcosis leading to respiratory failure Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Accumulation, Biological membranes
Under Development 1.2
214 Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon Open for adoption Under Development
  • Increased, seizure
  • Increased, agitation
  • Increased, depression
  • Increase, hypertension
232 NFE2/Nrf2 repression to steatosis Lyle Burgoon Open for adoption Under Development
  • NFE2/Nrf2 repression
  • Increased, steatosis
61 NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development
  • Activation, NRF2
  • Activation, NR1H4
  • Increased, Liver Steatosis
 1.29
77 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Carlie LaLone Open for comment. Do not cite Under Development
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
 1.29
87 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
 1.29
88 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Carlie LaLone Open for comment. Do not cite Under Development
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
 1.29
78 Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Carlie LaLone Open for comment. Do not cite Under Development
  • Activation, Nicotinic acetylcholine receptor
  • impaired, Larval development
  • Death/Failure, Colony
 1.29
90 Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Carlie LaLone Open for comment. Do not cite Under Development
  • Activation, Nicotinic acetylcholine receptor
  • impaired, Larval development
  • Death/Failure, Colony
 1.29
80 Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development
  • Activation, Nicotinic acetylcholine receptor
  • Decrease, Number of worker bees
  • impaired, Hive thermoregulation
  • Death/Failure, Colony
 1.29
79 Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
 1.29
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
 1.29
89 Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
 1.29
184 Nosema infection causes abnormal role change that leads to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development
  • Death/Failure, Colony
 1.29
183 Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development
  • Death/Failure, Colony
 1.29
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development
  • Activation, PXR/SXR
  • Increased, Liver Steatosis
 1.29
58 NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development
  • Suppression, Constitutive androstane receptor, NR1l3
  • Inhibition, PPAR alpha
  • Activation, LXR
  • peroxisome proliferator activated receptor promoter demethylation
  • Increased, Liver Steatosis
 1.29
227 NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon Open for adoption Under Development
  • Reduced, PTGS1 function
  • Activated, gastric ulcer formation
228 NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon Open for adoption Under Development
  • Reduced, PTGS2 function
  • Activated, gastric ulcer formation
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, organic anion transporter 1 (OAT1)
  • Increased Mortality
  • Decrease, Population growth rate
 1.29
405 Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function SAROJ AMAR Under development: Not open for comment. Do not cite
  • Acetylcholinesterase (AchE) Inhibition
  • Cognitive Function, Decreased
413 Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Zarin Hossain Open for citation & comment
  • Oxidation, Glutathione (To be considered with MIE)
  • Increased Mortality
31 Oxidation of iron in hemoglobin leading to hematotoxicity Mitchell S. Wilbanks Open for adoption Included in OECD Work Plan
  • N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)
  • N/A, Cyanosis occurs
Under Development 1.16
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk Open for comment. Do not cite Included in OECD Work Plan
  • Increase, Oxidative damage to DNA
  • Increase, Mutations
  • Increase, Chromosomal aberrations
EAGMST Approved 1.76
411 Oxidative stress Leading to Decreased Lung Function Karsta Luettich Open for comment. Do not cite
  • Oxidative Stress
  • Decrease, Lung function
424 Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Karsta Luettich Open for comment. Do not cite
  • Oxidative Stress
  • Decrease, Lung function
425 Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Karsta Luettich Open for comment. Do not cite
  • Oxidative Stress
  • Decrease, Lung function
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Annie Jarabek Under development: Not open for comment. Do not cite Under Development
192 Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Pendrin
  • Altered, Amphibian metamorphosis
 1.29
149 Peptide Oxidation Leading to Hypertension Frazer Lowe Not under active development Included in OECD Work Plan
  • Peptide Oxidation
  • Hypertension
Under Development 1.50
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno Not under active development Included in OECD Work Plan
  • Activation, PXR/SXR
Under Development 2.5
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development
  • Decreased, PPAR-alpha activation
  • Decreased, PPAR-beta activation
  • Decreased, PPAR-gamma activation
  • Increased, Liver Steatosis
 1.29
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inactivation of PPARγ
  • Lung fibrosis
Under Development 1.54
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi Under development: Not open for comment. Do not cite Under Development
  • Hepatotoxicity
130 Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity Jung-Hwa Oh Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Inhibition, Phospholipase A
  • Formation, Liver fibrosis
Under Development 1.39
371 Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone You Song Under development: Not open for comment. Do not cite
369 Photosystem II antagonism leading to growth inhibition via oxidative damage You Song Under development: Not open for comment. Do not cite
370 Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis You Song Under development: Not open for comment. Do not cite
446 PM-related Adverse outcome pathway frameworks on various systems Tianyu Li Under development: Not open for comment. Do not cite
454 PM2.5-related AOP frameworks on liver diseases Zhou Du Under development: Not open for comment. Do not cite
166 PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Increased, Pancreatic acinar tumors
 1.29
323 PPARalpha Agonism Impairs Fish Reproduction Ashley Kittelson Open for citation & comment
  • Activation, PPARα
  • Viable offspring, decreased
  • Decrease, Population growth rate
421 PPARG activation leading to intrahepatic cholestasis Yuan Jin Under development: Not open for comment. Do not cite
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Activation of specific nuclear receptors, PPAR-gamma activation
1.29
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard Open for citation & comment Included in OECD Work Plan
  • Activation, PPARα
  • impaired, Fertility
  • Malformation, Male reproductive tract
EAGMST Under Review 1.21
37 PPARα activation leading to hepatocellular adenomas and carcinomas in rodents Chris Corton Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Activation, PPARα
  • Increase, hepatocellular adenomas and carcinomas
Under Development 1.17
51 PPARα activation leading to impaired fertility in adult male rodents Elise Grignard Not under active development Included in OECD Work Plan
  • Activation, PPARα
  • impaired, Fertility
Under Development 1.21
230 presynaptic neuron 1 activation to epilepsy Lyle Burgoon Open for adoption Under Development
  • Activated, presynaptic neuron 1
  • Increased, epilepsy
231 presynaptic neuron 2 repression to epilepsy Lyle Burgoon Open for adoption Under Development
  • Reduced, presynaptic neuron 2 activity
  • Increased, epilepsy
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Prolyl hydroxylases
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
 1.29
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann Open for citation & comment Included in OECD Work Plan
  • Alkylation, Protein
  • N/A, Liver fibrosis
WPHA/WNT Endorsed 1.14
185 Queen egg-laying decrease leads to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development
  • Death/Failure, Colony
 1.29
453 Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population ruiyang Ding Under development: Not open for comment. Do not cite
438 reactive oxygen species generation leading to increased cardiovascular morbidity and mortality Yu Yang Under development: Not open for comment. Do not cite
469 Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population ruiyang Ding Under development: Not open for comment. Do not cite
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding of substrate, endocytic receptor
  • Occurrence, Kidney toxicity
Under Development 1.43
321 Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker Under development: Not open for comment. Do not cite
245 Reduction in photophosphorylation leading to growth inhibition in aquatic plants Knut Erik Tollefsen Under development: Not open for comment. Do not cite
  • Increase, Uncoupling of photophosphorylation
  • Decrease, Growth
258 Renal protein alkylation leading to kidney toxicity Angela Mally Not under active development Included in OECD Work Plan
  • Alkylation, Protein
  • Occurrence, Kidney toxicity
Under Development 1.43
448 ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality ruiyang Ding Under development: Not open for comment. Do not cite
342 S-adenosylmethionine depletion leading to population decline (1) You Song Under development: Not open for comment. Do not cite
  • Inhibition, Chitin synthase 1
  • Increase, Mortality
343 S-adenosylmethionine depletion leading to population decline (2) You Song Under development: Not open for comment. Do not cite
  • Increase, Sulfonylurea receptor binding
  • Increase, Mortality
406 SARS-CoV-2 infection leading to hyperinflammation Hasmik Yepiskoposyan Under development: Not open for comment. Do not cite
  • Binding to ACE2
  • Hyperinflammation
407 SARS-CoV-2 infection leading to pyroptosis Hasmik Yepiskoposyan Under development: Not open for comment. Do not cite
  • Binding to ACE2
  • Pyroptosis
394 SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) Sandra Coecke Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
  • impaired olfactory function (anosmia)
Under Development 1.96
426 SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. Evangelos-Panagiotis Daskalopoulos Under development: Not open for comment. Do not cite
  • Binding to ACE2
  • Myocardial Infarction
237 Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Sarah Søs Poulsen Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Sensing of the stressor by pulmonary cells
  • Plaque progression in arteries
Under Development 1.55
259 Sensitization induction of the intestinal tract by food proteins Erwin L Roggen Under development: Not open for comment. Do not cite
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Timothy Allen Not under active development Under Development
  • Serotonin 1A Receptor Agonism
  • Anti-depressant Activity
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Timothy Allen Not under active development Under Development
  • Serotonin 1A Receptor Agonism
  • Anti-depressant Activity
225 Serotonin transporter activation to agitation Lyle Burgoon Open for adoption Under Development
  • Increased, agitation
224 Serotonin transporter activation to depression Lyle Burgoon Open for adoption Under Development
  • Increased, serotonin transporter activity
  • Increased, depression
223 Serotonin transporter activation to seizure Lyle Burgoon Open for adoption Under Development
  • Increased, serotonin transporter activity
  • Increased, seizure
197 Sodium channel (Nav1.1) inhibition leading to population decline Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, sodium channel
1.29
94 Sodium channel inhibition leading to congenital malformations Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, sodium channel
  • Increased, amputations
 1.29
93 sodium channel inhibition leading to increased predation Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, sodium channel
  • Increased, predation
 1.29
91 Sodium channel inhibition leading to reduced survival Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, sodium channel
  • Reduced, feeding 1
  • Increased, predation
  • Reduced, survival
 1.29
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Na+/I- symporter (NIS)
  • Cognitive Function, Decreased
1.29
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Na+/I- symporter (NIS)
  • Altered, Amphibian metamorphosis
 1.29
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon Open for adoption Under Development
  • Decreased, serotonin transporter activity
  • Increase, hypertension
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Hiroyuki Komatsu Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Stimulation, TLR7/8
  • Psoriatic skin disease
Under Development 1.75
173 Substance interaction with the lung resident cell membrane components leading to lung fibrosis Sabina Halappanavar Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Substance interaction with the lung resident cell membrane components
  • Pulmonary fibrosis
EAGMST Under Review 1.32
474 Succinate dehydrogenase inactivation leading to cancer Sylvie Bortoli Under development: Not open for comment. Do not cite
361 Sulfonylureareceptor binding leading to mortality Simon Schmid Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Increase, Sulfonylurea receptor binding
  • Increase, Mortality
Under Development 1.94
457 Superoxide dismutase inhibition leading to increased insulin resistance Simon Thomas Under development: Not open for comment. Do not cite
85 Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development
  • Decrease, Number of worker bees
  • Death/Failure, Colony
 1.29
84 Suppression of immune system contributes to impaired development and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development
  • Decrease, Number of worker bees
  • impaired, Hive thermoregulation
  • Death/Failure, Colony
 1.29
41 Sustained AhR Activation leading to Rodent Liver Tumours Rick Becker Open for citation & comment Included in OECD Work Plan
  • Activation, Long term AHR receptor driven direct and indirect gene expression changes
  • Formation, Hepatocellular and Bile duct tumors
EAGMST Under Review 1.7
304 TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee Under development: Not open for comment. Do not cite
  • Inhibition, TBX1
  • Anomalies, Congenital cardiac conotruncal
375 test AOP Kevin Crofton Under development: Not open for comment. Do not cite
463 The AOP framwork on silica nanopariticles induced hepatoxicity Tianyu Li Under development: Not open for comment. Do not cite
324 Thermal stress leading to population decline (1) You Song Under development: Not open for comment. Do not cite
  • N/A, Mitochondrial dysfunction 1
  • Decrease, Fecundity
  • Decrease, Population growth rate
325 Thermal stress leading to population decline (2) You Song Under development: Not open for comment. Do not cite
  • N/A, Mitochondrial dysfunction 1
  • Decrease, Fecundity
  • Decrease, Population growth rate
326 Thermal stress leading to population decline (3) You Song Under development: Not open for comment. Do not cite
  • N/A, Mitochondrial dysfunction 1
  • Decrease, Fecundity
  • Decrease, Population growth rate
402 Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain Katherine (Katie) O'Shaughnessy Under development: Not open for comment. Do not cite
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Antagonism, Thyroid Receptor
  • Cognitive Function, Decreased
Under Development 1.84
175 Thyroperoxidase inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development
  • Thyroperoxidase, Inhibition
  • Altered, Amphibian metamorphosis
 1.29
365 Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning Lucia Vergauwen Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Thyroperoxidase, Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
Under Development 1.35
363 Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure Lucia Vergauwen Open for citation & comment Included in OECD Work Plan
  • Thyroperoxidase, Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
EAGMST Under Review 1.35
364 Thyroperoxidase inhibition leading to altered visual function via decreased eye size Lucia Vergauwen Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Thyroperoxidase, Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
Under Development 1.35
159 Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Thyroperoxidase, Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
347 Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Seokjoo Yoon Under development: Not open for comment. Do not cite
  • Toll-like receptor 4 activation
  • Inactivation of PPARγ
  • Pulmonary fibrosis
316 Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Trypsin inhibition
  • Pancreatic acinar cell tumors
Under Development 1.60
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Deiodinase 1
  • Altered, Amphibian metamorphosis
 1.29
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Deiodinase 2
  • Altered, Amphibian metamorphosis
 1.29
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Deiodinase 3
  • Altered, Amphibian metamorphosis
 1.29
263 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation You Song Open for citation & comment Included in OECD Work Plan
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
WPHA/WNT Endorsed 1.92
264 Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death You Song Open for citation & comment Included in OECD Work Plan
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity You Song Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion You Song Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium You Song Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
268 Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling You Song Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
186 unknown MIE leading to renal failure and mortality Kellie Fay Under Development: Contributions and Comments Welcome Under Development
  • Unknown, MIE
  • Increased Mortality
 1.29
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development
  • modulation, Unknown
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
 1.29
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Open for adoption Included in OECD Work Plan
  • Activation, Pregnane-X receptor, NR1l2
  • Loss, Cochlear function
Under Development 1.9
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development
  • Increase, Urinary bladder calculi
  • Increase, Adenomas/carcinomas (urothelial)
 1.29
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development
  • Death/Failure, Colony
 1.29
179 Varroa mite infestation increases virus levels leading to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development
  • Death/Failure, Colony
 1.29
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Jeanelle Martinez Under development: Not open for comment. Do not cite Under Development
  • TRPA1 activation, TRPA1 Receptor
  • Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
  • Irritation of nasal mucosa inducing sneeze reflex
  • Increased Respiratory irritability and Chronic Cough,
182 Weather event contributes abnormal foraging leading to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development
  • Death/Failure, Colony
 1.29
181 Weather event contributes to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development
  • Death/Failure, Colony
 1.29
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Tammy Stoker Under Development: Contributions and Comments Welcome Under Development
  • Inhibition, Inhibition of Dopamine-beta-hydroxylase
  • Decreased, Decreased fecundity
1.29
280 α-diketone-induced bronchiolitis obliterans Marvin Martens Under development: Not open for comment. Do not cite
  • Interaction of α-diketones with arginine residues
  • Bronchiolitis obliterans