API

AOPs

Id Title Point of Contact Author Status SAAOP Status MIE AO OECD Status OECD Project
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron Open for comment. Do not cite Included in OECD Work Plan 1252: Binding to (interferes with) topoisomerase II enzyme 1254: Infant leukaemia EAGMST Under Review 1.53
389 Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen Under development: Not open for comment. Do not cite 1865: Increase, Oxygen-evolving complex damage 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
98 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh Under Development: Contributions and Comments Welcome 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 588: Increased, predation 1.29
97 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Kellie Fay Under Development: Contributions and Comments Welcome Under Development 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 623: Increase, predation and 361: Decline, Population 1.29
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay Under Development: Contributions and Comments Welcome Under Development 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1164: Increased, Population 1.29
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Kellie Fay Under Development: Contributions and Comments Welcome Under Development 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1141: Decreased, Reproductive Success and 361: Decline, Population 1.29
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Kellie Fay Under Development: Contributions and Comments Welcome Under Development 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1163: Increased, Reproductive Success and 1164: Increased, Population 1.29
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite Included in OECD Work Plan 1617: 5α-reductase, inhibition 1688: decrease, male anogenital distance Under Development 1.90
82 Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development 566: impaired, Larval development and 563: Death/Failure, Colony 1.29
385 ACE2 dysregulation leading to microvascular disfunction Julija Filipovska Under development: Not open for comment. Do not cite 1739: ACE2 binding to viral S-protein
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve Under Development: Contributions and Comments Welcome Included in OECD Work Plan 12: Acetylcholinesterase (AchE) Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory Under Development 1.3
312 Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan Under development: Not open for comment. Do not cite 12: Acetylcholinesterase (AchE) Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
281 Acetylcholinesterase Inhibition Leading to Neurodegeneration Karen Watanabe Under development: Not open for comment. Do not cite 12: Acetylcholinesterase (AchE) Inhibition 352: N/A, Neurodegeneration
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi Under development: Not open for comment. Do not cite Under Development 1277: Reproductive failure
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon Open for citation & comment Included in OECD Work Plan 373: Formation, Pro-mutagenic DNA Adducts 378: Tumorigenesis, Hepatocellular carcinoma EAGMST Under Review 1.8
57 AhR activation leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development 18: Activation, AhR 455: Accumulation, Liver lipid 1.29
151 AhR activation leading to preeclampsia Sabrina Tait Under development: Not open for comment. Do not cite Included in OECD Work Plan 18: Activation, AhR 1893: increase, Preeclampsia Under Development 1.42
62 AKT2 activation leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development 486: systemic inflammation leading to hepatic steatosis 459: Increased, Liver Steatosis 1.29
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk Open for citation & comment Included in OECD Work Plan 97: Alkylation, DNA 336: Increase, Heritable mutations in offspring TFHA/WNT Endorsed 1.11
139 Alkylation of DNA leading to cancer 1 Carole Yauk Open for adoption Under Development 97: Alkylation, DNA 885: Increase, Cancer
322 Alkylation of DNA leading to reduced sperm count Carole Yauk Under development: Not open for comment. Do not cite 97: Alkylation, DNA 1757: Reduce, Sperm count
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Tammy Stoker Under Development: Contributions and Comments Welcome Under Development 849: Inhibition, Antgonism of NE receptor 527: Decreased, Decreased fecundity 1.29
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development 714: Increased, Binding of chemicals to 2u (serum) 713: Increase, Adenomas/carcinomas (renal tubular) 1.29
104 Altered ion channel activity leading impaired heart function Kevin Dreher Under Development: Contributions and Comments Welcome Under Development 697: impaired, ion channels 351: Increased Mortality 1.29
345 Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen Under development: Not open for comment. Do not cite 26: Antagonism, Androgen receptor 972: Decreased fertility, Reduced number of oocytes ovulated
344 Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite 26: Antagonism, Androgen receptor 1786: increase, retained nipples in males
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite Included in OECD Work Plan 26: Antagonism, Androgen receptor 1688: decrease, male anogenital distance Under Development 1.90
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Open for adoption Included in OECD Work Plan 785: Activation, Androgen receptor 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.26
376 Androgen receptor agonism leading to male-biased sex ratio Dan Villeneuve Under development: Not open for comment. Do not cite 25: Agonism, Androgen receptor 360: Decrease, Population trajectory
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve Open for citation & comment Included in OECD Work Plan 25: Agonism, Androgen receptor 360: Decrease, Population trajectory TFHA/WNT Endorsed 1.12
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel Open for adoption Under Development 27: N/A, Androgen receptor, Antagonism 337: N/A, Impairment of reproductive capacity
372 Androgen receptor antagonism leading to testicular cancer Chander K. Negi Under development: Not open for comment. Do not cite 26: Antagonism, Androgen receptor 1839: Testicular Cancer
382 Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Young Jun Kim Under development: Not open for comment. Do not cite 1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) 1276: Lung fibrosis
6 Antagonist binding to PPARα leading to body-weight loss Kurt A. Gust Open for citation & comment Included in OECD Work Plan 998: Binding of antagonist, PPAR alpha 864: Decreased, Body Weight TFHA/WNT Endorsed 2.3
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Charles Wood Under Development: Contributions and Comments Welcome Under Development 1079: Increased, Adenomas/carcinomas (mammary) 1.29
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Barnett Rattner Not under active development Included in OECD Work Plan 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone and 1138: Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP and 1169: 1136: Impaired recruitment , Population trajectory Under Development 1.31
165 Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Charles Wood Under Development: Contributions and Comments Welcome Under Development 1053: Promotion, ovarian adenomas and 1054: Promotion, ovarian granular cell tumors 1.29
393 AOP for thyroid disorder caused by triphenyl phosphate Fei Li Under development: Not open for comment. Do not cite
335 AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza Under development: Not open for comment. Do not cite 1261: Mitochondrial impairment 1763: Urothelial Tumor
205 AOP from chemical insult to cell death Mathieu Vinken Open for comment. Do not cite Under Development 1258: Decompartmentalization and 1260: Direct mitochondrial inhibition and 1259: narcosis 1262: Apoptosis and 1263: Necrosis
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard Open for citation & comment Included in OECD Work Plan 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) 406: impaired, Fertility and 405: irregularities, ovarian cycle EAGMST Under Review 1.21
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Tammy Stoker Under Development: Contributions and Comments Welcome Under Development 964: Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol 972: Decreased fertility, Reduced number of oocytes ovulated 1.29
25 Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan 36: Inhibition, Aromatase 360: Decrease, Population trajectory TFHA/WNT Endorsed 1.12
346 Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez Under Development: Contributions and Comments Welcome 36: Inhibition, Aromatase 360: Decrease, Population trajectory
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker Open for citation & comment Included in OECD Work Plan 18: Activation, AhR TFHA/WNT Endorsed 1.27
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat Open for citation & comment Included in OECD Work Plan 18: Activation, AhR 947: Increase, Early Life Stage Mortality TFHA/WNT Endorsed 1.7
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat Open for citation & comment Included in OECD Work Plan 18: Activation, AhR 369: Uroporphyria TFHA/WNT Endorsed 1.7
96 Axonal sodium channel modulation leading to acute mortality Kellie Fay Under Development: Contributions and Comments Welcome Under Development 598: modulation, sodium channel 351: Increased Mortality 1.29
164 Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Charles Wood Under Development: Contributions and Comments Welcome Under Development 1038: Activation, beta-2 adrenergic receptor 1044: Promotion, mesovarian leiomyomas 1.29
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price Open for citation & comment Included in OECD Work Plan 875: Binding of agonist, Ionotropic glutamate receptors 341: Impairment, Learning and memory TFHA/WNT Endorsed 1.23
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich Under development: Not open for comment. Do not cite Included in OECD Work Plan 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 341: Impairment, Learning and memory EAGMST Under Review 1.13
284 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois Under development: Not open for comment. Do not cite 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 1603: Chronic kidney disease
374 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Anna Price Under development: Not open for comment. Do not cite 1739: ACE2 binding to viral S-protein 1841: Encephalitis
395 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) Magda Sachana Under development: Not open for comment. Do not cite 1739: ACE2 binding to viral S-protein 1875: Cerebrovascular disease (stroke)
320 Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim Open for comment. Do not cite 1739: ACE2 binding to viral S-protein 351: Increased Mortality
381 Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Young Jun Kim Under development: Not open for comment. Do not cite 1739: ACE2 binding to viral S-protein 1850: dysgeusia
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Yasuharu Otsubo Under development: Not open for comment. Do not cite Included in OECD Work Plan 1710: Binding to estrogen receptor (ER)-α in immune cells 1714: Exacerbation of systemic lupus erythematosus (SLE) Under Development 1.73
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Ping Gong Open for citation & comment Included in OECD Work Plan 667: Binding at picrotoxin site, iGABAR chloride channel 613: Occurrence, Epileptic seizure TFHA/WNT Endorsed 1.15
397 Bulky DNA adducts leading to mutations Carole Yauk Under development: Not open for comment. Do not cite 1879: Bulky DNA adducts, increase 185: Increase, Mutations
26 Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon Open for adoption Under Development 51: Inhibition, Ca++ ATPase 356: Increased, Oxidative damage
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti Open for citation & comment Included in OECD Work Plan 718: Binding, Tubulin 728: Increase, Aneuploid offspring EAGMST Under Review 1.11
360 Chitin synthase 1 inhibition leading to mortality Simon Schmid Open for citation & comment Included in OECD Work Plan 1522: Inhibition, Chitin synthase 1 350: Increase, Mortality EAGMST Under Review 1.94
358 Chitinase inhibition leading to mortality Simon Schmid Under development: Not open for comment. Do not cite 1806: Increase, Chitinase inhibition 350: Increase, Mortality
359 Chitobiase inhibition leading to mortality Simon Schmid Under development: Not open for comment. Do not cite 1807: Increase, Chitobiase inhibition 350: Increase, Mortality
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken Under development: Not open for comment. Do not cite Included in OECD Work Plan 41: Inhibition, Bile Salt Export Pump (ABCB11) 357: Cholestasis, Pathology Under Development 1.19
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price Open for citation & comment Included in OECD Work Plan 201: Binding of antagonist, NMDA receptors 341: Impairment, Learning and memory TFHA/WNT Endorsed 1.22
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet Open for citation & comment Included in OECD Work Plan 201: Binding of antagonist, NMDA receptors 352: N/A, Neurodegeneration and 341: Impairment, Learning and memory TFHA/WNT Endorsed 1.13
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development 786: Increase, Cytotoxicity (hepatocytes) 719: Increase, hepatocellular adenomas and carcinomas 1.29
171 Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Charles Wood Under Development: Contributions and Comments Welcome Under Development 1090: Increased, mesotheliomas 1.29
298 Chronic reactive oxygen species leading to human treatment-resistant gastric cancer Shihori Tanabe Open for comment. Do not cite Included in OECD Work Plan 1753: Chronic reactive oxygen species 1651: Treatment-resistant gastric cancer EAGMST Under Review 1.58
403 combined unhealthy lifestyle factors leading to metabolic syndrome Gillina Bezemer Under development: Not open for comment. Do not cite
367 Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite 1831: Binding, Thyroid binding globulin in serum 1101: Altered, Amphibian metamorphosis
366 Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite 957: Binding, Transthyretin in serum 1101: Altered, Amphibian metamorphosis
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser Open for citation & comment Included in OECD Work Plan 715: Activation, Constitutive androstane receptor 719: Increase, hepatocellular adenomas and carcinomas EAGMST Under Review 1.17
39 Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins leads to Sensitisation (Sensitization) of the Respiratory Tract Kristie Sullivan Under Development: Contributions and Comments Welcome Included in OECD Work Plan 396: Covalent Binding, Protein 313: Increase, Allergic Respiratory Hypersensitivity Response Under Development 1.20
40 Covalent Protein binding leading to Skin Sensitisation Sharon Munn Open for citation & comment Included in OECD Work Plan 396: Covalent Binding, Protein 827: sensitisation, skin TFHA/WNT Endorsed 1.1
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Kellie Fay Under Development: Contributions and Comments Welcome Under Development 1103: Inhibition, Cyclooxygenase 1 activity 351: Increased Mortality and 361: Decline, Population 1.29
28 Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve Under Development: Contributions and Comments Welcome Under Development 79: Inhibition, Cyclooxygenase activity 253: N/A, Reproductive failure 1.29
63 Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory 1.29
100 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory 1.29
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory 1.29
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory 1.29
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory 1.29
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders Under development: Not open for comment. Do not cite 1508: CYP2E1 Activation and 1509: Protein Adduct Formation 1514: Neurodegeneration
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster Open for citation & comment Included in OECD Work Plan 1391: Activation of Cyp2E1 1395: Liver Cancer EAGMST Under Review 1.24
368 Cytochrome oxidase inhibition leading to olfactory nasal lesions Katy Goyak Under development: Not open for comment. Do not cite 1840: Inhibition, cytochrome oxidase 872: Increase, Site of Contact Nasal Tumors
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood Under Development: Contributions and Comments Welcome Under Development 770: Increase, Cytotoxicity (club cells) 736: Increase, Adenomas/carcinomas (bronchioloalveolar) 1.29
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development 783: Increase, Cytotoxicity (tubular epithelial cells) 713: Increase, Adenomas/carcinomas (renal tubular) 1.29
86 Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development 566: impaired, Larval development and 563: Death/Failure, Colony 1.29
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development 742: Decreased, Androgen receptor activity 745: Increase, Leydig cell tumors 1.29
392 Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation Penny Nymark Under development: Not open for comment. Do not cite 1866: Fibrinolysis, decreased and 1867: Bradykinin system, hyperactivated 1868: Hyperinflammation
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite Included in OECD Work Plan 1688: decrease, male anogenital distance Under Development 1.90
158 Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen Open for adoption Included in OECD Work Plan 1009: Inhibition, Deiodinase 1 351: Increased Mortality and 360: Decrease, Population trajectory EAGMST Under Review 1.35
157 Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen Open for adoption Included in OECD Work Plan 1009: Inhibition, Deiodinase 1 351: Increased Mortality and 360: Decrease, Population trajectory EAGMST Under Review 1.35
156 Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen Open for adoption Included in OECD Work Plan 1002: Inhibition, Deiodinase 2 351: Increased Mortality and 360: Decrease, Population trajectory EAGMST Under Review 1.35
155 Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen Open for adoption Included in OECD Work Plan 1002: Inhibition, Deiodinase 2 351: Increased Mortality and 360: Decrease, Population trajectory EAGMST Under Review 1.35
272 Deposition of energy leading to lung cancer Vinita Chauhan Under development: Not open for comment. Do not cite Included in OECD Work Plan 1686: Direct Deposition of Energy 1556: Increase, lung cancer EAGMST Under Review 1.56
396 Deposition of ionizing energy leads to population decline via impaired meiosis Erica Maremonti Under development: Not open for comment. Do not cite 1550: Direct Deposition of Ionizing Energy and 1115: Increased, Reactive oxygen species and 1194: Increase, DNA damage 1696: Decrease of egg production and cummulative fecundity and 997: Decreased, Population size
43 Disruption of VEGFR Signaling Leading to Developmental Defects Tom Knudsen Open for citation & comment Included in OECD Work Plan 305: Inhibition, VegfR2 1001: Increased, Developmental Defects EAGMST Under Review 1.6
240 DNA Adducts Leading to Liver Hemangiosarcoma Annie Jarabek Under development: Not open for comment. Do not cite Under Development
388 DNA damage leading to population decline via programmed cell death Knut Erik Tollefsen Under development: Not open for comment. Do not cite 1194: Increase, DNA damage 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
336 DNA methyltransferase inhibition leading to population decline (1) You Song Under Development: Contributions and Comments Welcome Under Development 1619: Increase, DNA methyltransferase inhibition 328: Decrease, Fecundity and 360: Decrease, Population trajectory
337 DNA methyltransferase inhibition leading to population decline (2) You Song Under Development: Contributions and Comments Welcome Under Development 1619: Increase, DNA methyltransferase inhibition 328: Decrease, Fecundity and 360: Decrease, Population trajectory
338 DNA methyltransferase inhibition leading to population decline (3) You Song Under Development: Contributions and Comments Welcome 1619: Increase, DNA methyltransferase inhibition 328: Decrease, Fecundity and 360: Decrease, Population trajectory
339 DNA methyltransferase inhibition leading to population decline (4) You Song Under Development: Contributions and Comments Welcome Under Development 1619: Increase, DNA methyltransferase inhibition 328: Decrease, Fecundity and 360: Decrease, Population trajectory
340 DNA methyltransferase inhibition leading to transgenerational effects (1) You Song Under Development: Contributions and Comments Welcome Under Development 1619: Increase, DNA methyltransferase inhibition 1781: Decrease, Fecundity (F3) and 360: Decrease, Population trajectory
341 DNA methyltransferase inhibition leading to transgenerational effects (2) You Song Under Development: Contributions and Comments Welcome Under Development 1619: Increase, DNA methyltransferase inhibition 1781: Decrease, Fecundity (F3) and 360: Decrease, Population trajectory
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1156: Inhibition, Dual oxidase 1101: Altered, Amphibian metamorphosis 1.29
377 Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction (MOD) Gillina Bezemer Under development: Not open for comment. Do not cite 1842: Prolonged TLR9 activation 1843: Acute Respiratory Distress Syndrome and Multiple Organ Dysfunction and 351: Increased Mortality
378 Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Gillina Bezemer Under development: Not open for comment. Do not cite
167 Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Charles Wood Under Development: Contributions and Comments Welcome Under Development 1064: prepubertal increase, Estrogen receptor (ER) activity 1070: Increased, adenosquamous carcinomas of endometrium 1.29
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.79
4 Ecdysone receptor agonism leading to incomplete ecdysis associated mortality Knut Erik Tollefsen Open for citation & comment Under Development 103: Increase, Ecdysone receptor agonism
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich Under development: Not open for comment. Do not cite Included in OECD Work Plan 941: Activation, EGFR 1250: Decrease, Lung function Under Development 1.51
269 Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild Under development: Not open for comment. Do not cite
270 Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild Under development: Not open for comment. Do not cite
310 Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering Under development: Not open for comment. Do not cite 18: Activation, AhR 78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic Under development: Not open for comment. Do not cite Included in OECD Work Plan 1539: Endocytotic lysosomal uptake 344: N/A, Liver fibrosis EAGMST Under Review 1.47
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Charles Wood Under Development: Contributions and Comments Welcome Under Development 1026: Increased Apoptosis, Adenomas/carcinomas (follicular cell) 1.29
72 Epigenetic modification of PPARG leading to adipogenesis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development 228: peroxisome proliferator activated receptor promoter demethylation and 1454: chronic high fat diet 1447: obesity 1.29
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development 780: Increase, Cytotoxicity (epithelial cells) 779: Increase, Papillomas/carcinomas (squamous cells) 1.29
53 ER agonism leading to reduced survival due to renal failure Tom Hutchinson Under Development: Contributions and Comments Welcome Under Development 111: Agonism, Estrogen receptor 1.29
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Tom Hutchinson Under Development: Contributions and Comments Welcome Under Development 111: Agonism, Estrogen receptor 417: skewed, sex ratio 1.29
199 ER mediated breast cancer AOP Molly M Morgan Under development: Not open for comment. Do not cite Under Development
146 Estrogen Receptor Activation and Female Precocious Puberty Jeff Welch Under Development: Contributions and Comments Welcome Under Development 1.29
200 Estrogen receptor activation leading to breast cancer Molly M Morgan Open for adoption Under Development 1181: Activation, Estrogen receptor 1193: N/A, Breast Cancer
29 Estrogen receptor agonism leading to reproductive dysfunction Tom Hutchinson Under Development: Contributions and Comments Welcome Under Development 111: Agonism, Estrogen receptor 360: Decrease, Population trajectory and 363: Altered, Reproductive behaviour and 339: Altered, Larval development and 364: Impaired development of, Reproductive organs 1.29
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan 112: Antagonism, Estrogen receptor 360: Decrease, Population trajectory EAGMST Under Review 1.12
95 Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Kellie Fay Under Development: Contributions and Comments Welcome Under Development 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel 592: Reduced, survival 1.29
327 Excessive reactive oxygen species production leading to mortality (1) You Song Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
328 Excessive reactive oxygen species production leading to mortality (2) You Song Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
329 Excessive reactive oxygen species production leading to mortality (3) You Song Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
330 Excessive reactive oxygen species production leading to mortality (4) You Song Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
216 Excessive reactive oxygen species production leading to population decline via follicular atresia Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
238 Excessive reactive oxygen species production leading to population decline via lipid peroxidation Knut Erik Tollefsen Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
311 Excessive reactive oxygen species production leading to population decline via mitochondrial dysfunction You Song Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
299 Excessive reactive oxygen species production leading to population decline via reduced fatty acid beta-oxidation You Song Under development: Not open for comment. Do not cite Under Development 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
331 Formation of DNA photoproducts leading to growth inhibition (1) You Song Under development: Not open for comment. Do not cite 1765: Increase, Formation of DNA photoproducts 350: Increase, Mortality
332 Formation of DNA photoproducts leading to growth inhibition (2) You Song Under development: Not open for comment. Do not cite
333 Formation of DNA photoproducts leading to growth inhibition (3) You Song Under development: Not open for comment. Do not cite
409 Frustrated phagocytosis leads to malignant mesothelioma Nureddin Mansour Under development: Not open for comment. Do not cite
303 Frustrated phagocytosis-induced lung cancer Carole Seidel Under development: Not open for comment. Do not cite Included in OECD Work Plan 1668: Frustrated phagoytosis 1670: Lung cancer Under Development 1.86
401 G protein-coupled estrogen receptor 1 (GPER) signal pathway in the endocrine disrupting effect Fei Li Under development: Not open for comment. Do not cite
217 Gastric ulcer formation Lyle Burgoon Open for adoption Under Development 1367: Inhibit, gastric ulcer formation and 1385: Activated, gastric ulcer formation
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Susan Laws Under Development: Contributions and Comments Welcome Under Development 494: Glucocorticoid Receptor Agonist, Activation 406: impaired, Fertility 1.29
318 Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi Under Development: Contributions and Comments Welcome 122: Activation, Glucocorticoid Receptor 459: Increased, Liver Steatosis
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone Open for comment. Do not cite 122: Activation, Glucocorticoid Receptor 323: Increased, Disease susceptibility 1.29
334 Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Alexander Cole Under development: Not open for comment. Do not cite 122: Activation, Glucocorticoid Receptor 360: Decrease, Population trajectory
113 Glutamate-gated chloride channel activation leading to acute mortality Kellie Fay Under Development: Contributions and Comments Welcome Under Development 760: Activation, Glutamate-gated chloride channel 351: Increased Mortality and 765: Decreased, population 1 1.29
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development 1018: Activation, Glutamate-gated chloride channels 351: Increased Mortality
168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Charles Wood Under Development: Contributions and Comments Welcome Under Development 1079: Increased, Adenomas/carcinomas (mammary) 1.29
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Charles Wood Under Development: Contributions and Comments Welcome Under Development 1082: Increased, adenomas (pituitary) 1.29
211 Handbook development AOP Dan Villeneuve Under Development: Contributions and Comments Welcome Under Development 1.29
229 Helicobacter pylori to gastric ulcer Lyle Burgoon Open for adoption Under Development 1412: Helicobacter pylori infection 1385: Activated, gastric ulcer formation
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1157: Activation, Hepatic nuclear receptor(s) 1101: Altered, Amphibian metamorphosis 1.29
99 Histamine (H2) receptor antagonism leading to reduced survival Kellie Fay Under Development: Contributions and Comments Welcome Under Development 638: Antagonism, Histamine Receptor (H2) 636: Decreased, survival and 588: Increased, predation 1.29
212 Histone deacetylase inhibition leading to testicular atrophy Shihori Tanabe Open for citation & comment Included in OECD Work Plan 1502: Histone deacetylase inhibition 1506: Testicular atrophy EAGMST Under Review 1.52
274 Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens Under development: Not open for comment. Do not cite 1502: Histone deacetylase inhibition 1559: Facial cartilage structures are reduced in size and morphologically distorted
275 Histone deacetylase inhibition leads to neural tube defects Marvin Martens Under development: Not open for comment. Do not cite 1502: Histone deacetylase inhibition 1561: Neural tube defects
124 HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay Under Development: Contributions and Comments Welcome Under Development 804: Inhibition, HMG-CoA reductase 330: Decrease, Fertility 1.29
59 HNF4alpha suppression leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development 461: Suppression, HNF4alpha 1.29
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development 766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme 779: Increase, Papillomas/carcinomas (squamous cells) 1.29
384 Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Young Jun Kim Under development: Not open for comment. Do not cite 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1603: Chronic kidney disease
278 IKK complex inhibition leading to liver injury Nanette Vrijenhoek Under development: Not open for comment. Do not cite 1574: Inhibition, IKK complex 1548: Necrotic Tissue and 1549: Liver Injury
408 Imbalance in redox homeostasis leading to structural damage to tissues Fei Li Under development: Not open for comment. Do not cite
362 Immune mediated hepatitis Jung-Hwa Oh Under development: Not open for comment. Do not cite 1814: benzoquinone imine and acylglucuronide metabolites 1820: Immune mediated hepatitis
277 Impaired IL-1R1 signaling leading to increased susceptibility to infection Yutaka Kimura Open for citation & comment Included in OECD Work Plan 1700: Impaired IL-1R1 signaling 986: Increase, Increased susceptibility to infection EAGMST Under Review 1.48
400 Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males Terje Svingen Under development: Not open for comment. Do not cite 1888: Increased (ectopic) all-trans retinoic acid concentration 1757: Reduce, Sperm count
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm Under development: Not open for comment. Do not cite Included in OECD Work Plan 1194: Increase, DNA damage 185: Increase, Mutations and 1192: Increased, Ductal Hyperplasia and 1193: N/A, Breast Cancer Under Development 1.80
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development 746: Increase, Dopaminergic activity 773: Increase, Endometrial adenocarcinomas 1.29
81 Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development 572: Decrease, Number of worker bees and 563: Death/Failure, Colony 1.29
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm Under development: Not open for comment. Do not cite Included in OECD Work Plan 1632: Increase in reactive oxygen and nitrogen species (RONS) 1194: Increase, DNA damage and 185: Increase, Mutations and 1192: Increased, Ductal Hyperplasia and 1193: N/A, Breast Cancer Under Development 1.80
386 Increased reactive oxygen species production leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
387 Increased reactive oxygen species production leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
379 Increased susceptibility to viral entry and coronavirus production leading to thrombosis and disseminated intravascular coagulation Shihori Tanabe Under development: Not open for comment. Do not cite 1738: Increased susceptibility to viral entry 1847: Increased coronavirus production and 1846: Thrombosis and Disseminated Intravascular Coagulation
349 Inhibition of 11β-hydroxylase leading to decresed population trajectory Young Jun Kim Under development: Not open for comment. Do not cite 1796: 11β-hydroxylase inhibition 360: Decrease, Population trajectory
348 Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory Young Jun Kim Under development: Not open for comment. Do not cite 1799: Inhibition of 11β-HSD 360: Decrease, Population trajectory
288 Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET Open for citation & comment 1609: Inhibition, Cytochrome P450 enzyme (CYP17A1) activity 1616: Malformation, cryptorchidism - maldescended testis
289 Inhibition of 5α-reductase leading to impaired fecundity in female fish Young Jun Kim Open for citation & comment Included in OECD Work Plan 1617: 5α-reductase, inhibition 360: Decrease, Population trajectory Under Development 1.81
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development 790: Inhibition, 5α-reductase activity 745: Increase, Leydig cell tumors 1.29
398 Inhibition of ALDH1A2 (RALDH2) causing reduced all-trans retinoic acid levels leading to decreased fertility, females Terje Svingen Under development: Not open for comment. Do not cite 1880: Inhibition of ALDH1A2 (RALDH2) 972: Decreased fertility, Reduced number of oocytes ovulated
383 Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Young Jun Kim Under development: Not open for comment. Do not cite 1740: ACE2 inhibition 344: N/A, Liver fibrosis
319 Inhibition of Angiotensin-converting enzyme 2 leading to lung fibrosis Young Jun Kim Open for comment. Do not cite 1740: ACE2 inhibition 1276: Lung fibrosis
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Takumi Ohishi Open for comment. Do not cite Included in OECD Work Plan 980: Inhibition, Calcineurin Activity 984: Impairment, T-cell dependent antibody response EAGMST Under Review 1.38
276 Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens Under development: Not open for comment. Do not cite 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 1564: Chemical induced Fanconi syndrome
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière Not under active development Under Development 1386: CYP7B activity, inhibition 442: Decreased, Population trajectory
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière Not under active development Under Development 1386: CYP7B activity, inhibition 442: Decreased, Population trajectory
301 Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim Under development: Not open for comment. Do not cite 1657: Inhibition of cystathionine beta-synthase 1667: Impaired,anterior-posterior axis development
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon Open for adoption Under Development 1490: Inhibition, Fatty Acid Beta Oxidation 1489: N/A, Steatohepatisis
399 Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) Vid Modic Under development: Not open for comment. Do not cite 1884: Inhibition of Fyna 351: Increased Mortality and 360: Decrease, Population trajectory
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Michelle Embry Not under active development Under Development
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood Under Development: Contributions and Comments Welcome Under Development 737: Decreased, Uptake of inorganic iodide 741: Increase, Adenomas/carcinomas (follicular cell) 1.29
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Yasuhiro Yoshida Under development: Not open for comment. Do not cite Included in OECD Work Plan 1715: Inhibition of JAK3 1719: Impairment of T-cell dependent antibody response Under Development 1.74
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz Open for adoption 1462: Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts 1467: Growth, reduction and 636: Decreased, survival
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite Included in OECD Work Plan 1481: Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) 814: Occurrence, Kidney toxicity Under Development 1.43
285 Inhibition of N-linked glycosylation leads to liver injury Marvin Martens Under development: Not open for comment. Do not cite 1604: Inhibition of N-linked glycosylation 1549: Liver Injury
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price Open for citation & comment Included in OECD Work Plan 424: Inhibition, Na+/I- symporter (NIS) 341: Impairment, Learning and memory TFHA/WNT Endorsed 1.28
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development 724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme 719: Increase, hepatocellular adenomas and carcinomas 1.29
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Young Jun Kim Under Development: Contributions and Comments Welcome Included in OECD Work Plan 1637: Retinaldehyde dehydrogenase inhibition 360: Decrease, Population trajectory Under Development 1.77
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron Open for citation & comment Included in OECD Work Plan 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 896: Parkinsonian motor deficits TFHA/WNT Endorsed 1.33
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood Under Development: Contributions and Comments Welcome Under Development 279: Thyroperoxidase, Inhibition 741: Increase, Adenomas/carcinomas (follicular cell) 1.29
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park Open for comment. Do not cite Included in OECD Work Plan 279: Thyroperoxidase, Inhibition 78: Reduction, Cumulative fecundity and spawning Under Development 1.59
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton Open for citation & comment Included in OECD Work Plan 279: Thyroperoxidase, Inhibition 402: Cognitive Function, Decreased TFHA/WNT Endorsed 1.10
292 Inhibition of tyrosinase leads to decreased population in fish Young Jun Kim Open for citation & comment Included in OECD Work Plan 1627: Inhibition of tyrosinase 360: Decrease, Population trajectory Under Development 1.78
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Kristie Sullivan Under Development: Contributions and Comments Welcome Included in OECD Work Plan 957: Binding, Transthyretin in serum 402: Cognitive Function, Decreased Under Development 1.41
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Justin Teeguarden Open for citation & comment Included in OECD Work Plan 867: Decrease, Intracellular pH 872: Increase, Site of Contact Nasal Tumors EAGMST Under Review 2.7
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1152: Inhibition, Iodotyrosine deiodinase (IYD) 1101: Altered, Amphibian metamorphosis 1.29
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development 762: Activation, ionotropic GABA Receptor chloride channel 351: Increased Mortality
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi Under development: Not open for comment. Do not cite Under Development 1277: Reproductive failure
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development 1205: Activation, Juvenile hormone receptor 1208: Increased, Male offspring and 361: Decline, Population and 1210: Alteration, Food-web structures
128 Kidney dysfunction by decreased thyroid hormone Jung-Hwa Oh Under development: Not open for comment. Do not cite Included in OECD Work Plan 277: Thyroid hormone synthesis, Decreased 814: Occurrence, Kidney toxicity Under Development 1.40
33 Kidney toxicity induced by activation of 5HT2C Kevin Crofton Open for adoption Under Development 9: Activation, 5HT2c 759: Increased, Kidney Failure
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite Included in OECD Work Plan 1529: Blockade, L-Type Calcium Channels 1535: Heart failure Under Development 1.45
283 L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens Under development: Not open for comment. Do not cite 1468: Activation, Latent Transforming Growth Factor Beta 1 1458: Pulmonary fibrosis
302 Lung surfactant function inhibition leading to decreased lung function Jorid Birkelund Sørli Open for comment. Do not cite Included in OECD Work Plan 1672: Inhibition of lung surfactant function 1250: Decrease, Lung function Under Development 1.87
309 Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim Under Development: Contributions and Comments Welcome 1691: Antagonism,LH receptor 679: Decline, Population trajectory
34 LXR activation leading to hepatic steatosis Marina Goumenou Not under active development Under Development 167: Activation, LXR and 228: peroxisome proliferator activated receptor promoter demethylation 345: N/A, Liver Steatosis
222 Mental stress to agitation Lyle Burgoon Open for adoption Under Development 1396: Increased, glucocorticoid receptor activity 1345: Increased, agitation
221 Mental stress to depression Lyle Burgoon Open for adoption Under Development 1396: Increased, glucocorticoid receptor activity 1346: Increased, depression
404 Metabolic Syndrome leading to Toll Like Receptor dysregulation Gillina Bezemer Under development: Not open for comment. Do not cite
279 Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens Under development: Not open for comment. Do not cite 1580: Binding of microtubule stabilizing agents (MSA) to microtubules 1583: Sensory axonal peripheral neuropathy
290 Mitochondrial ATP synthase antagonism leading to growth inhibition (1) You Song Under development: Not open for comment. Do not cite Under Development 1785: Increase, Mitochondrial ATP synthase antagonism 1521: Decrease, Growth
291 Mitochondrial ATP synthase antagonism leading to growth inhibition (2) You Song Under development: Not open for comment. Do not cite Under Development 1785: Increase, Mitochondrial ATP synthase antagonism 1521: Decrease, Growth
286 Mitochondrial complex III antagonism leading to growth inhibition (1) You Song Under development: Not open for comment. Do not cite Under Development 1542: Increase, Mitochondrial complex III antagonism 1521: Decrease, Growth
287 Mitochondrial complex III antagonism leading to growth inhibition (2) You Song Under development: Not open for comment. Do not cite Under Development 1542: Increase, Mitochondrial complex III antagonism 1521: Decrease, Growth
273 Mitochondrial complex inhibition leading to liver injury Wanda van der Stel Under development: Not open for comment. Do not cite 1542, 1543, 1544, 888, 887, 1653, 1654, 1655 1548: Necrotic Tissue and 1549: Liver Injury
373 Mitochondrial dysfunction to metabolic diseases Chander K. Negi Under Development: Contributions and Comments Welcome
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development 653: Decreased testosterone by the fetal Leydig cells, Increased corticosterone and 654: Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists 505: Decreased sperm quantity / quality in the adult, Decreased fertility 1.29
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome 505: Decreased sperm quantity / quality in the adult, Decreased fertility 1.29
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development 642: Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol and 643: Decreased Cholesterol, Decreased Uptake of Lipoproteins and 644: Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane 646: Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis 1.29
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development 658: Decreased testosterone by the fetal Leydig cells, Increased estradiol and 659: Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists 505: Decreased sperm quantity / quality in the adult, Decreased fertility 1.29
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid 520: Decreased sperm quantity or quality in the adult, Decreased fertility 1.29
74 Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development 662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis 543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis 1.29
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell 520: Decreased sperm quantity or quality in the adult, Decreased fertility 1.29
215 Molecular events lead to epilepsy Lyle Burgoon Open for adoption Under Development 1348: Increase, seizure and 1362: Increased, hippocampal hyperdepolarization and 1363: Increased, epilepsy
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Timothy Allen Not under active development Under Development 1425: Mu Opioid Receptor Agonism 1428: Analgesia
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen Not under active development Under Development 1425: Mu Opioid Receptor Agonism 1428: Analgesia
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Jinhee Choi Under development: Not open for comment. Do not cite Under Development 1174: Activation, NADPH Oxidase 1277: Reproductive failure
35 Narcosis leading to respiratory failure Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan 46: Accumulation, Biological membranes Under Development 1.2
214 Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon Open for adoption Under Development 1344: Increased, seizure and 1345: Increased, agitation and 1346: Increased, depression and 1343: Increase, hypertension
232 NFE2/Nrf2 repression to steatosis Lyle Burgoon Open for adoption Under Development 1417: NFE2/Nrf2 repression 1418: Increased, steatosis
61 NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development 478: Activation, NRF2 and 479: Activation, NR1H4 459: Increased, Liver Steatosis 1.29
77 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Carlie LaLone Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony 1.29
87 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony 1.29
88 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Carlie LaLone Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony 1.29
78 Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Carlie LaLone Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 566: impaired, Larval development and 563: Death/Failure, Colony 1.29
90 Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Carlie LaLone Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 566: impaired, Larval development and 563: Death/Failure, Colony 1.29
80 Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 572: Decrease, Number of worker bees and 568: impaired, Hive thermoregulation and 563: Death/Failure, Colony 1.29
79 Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony 1.29
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony 1.29
89 Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony 1.29
184 Nosema infection causes abnormal role change that leads to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 563: Death/Failure, Colony 1.29
183 Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 563: Death/Failure, Colony 1.29
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development 245: Activation, PXR/SXR 459: Increased, Liver Steatosis 1.29
58 NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development 456: Suppression, Constitutive androstane receptor, NR1l3 and 468: Inhibition, PPAR alpha and 167: Activation, LXR and 228: peroxisome proliferator activated receptor promoter demethylation 459: Increased, Liver Steatosis 1.29
227 NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon Open for adoption Under Development 1402: Reduced, PTGS1 function 1385: Activated, gastric ulcer formation
228 NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon Open for adoption Under Development 1408: Reduced, PTGS2 function 1385: Activated, gastric ulcer formation
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay Under Development: Contributions and Comments Welcome Under Development 877: Inhibition, organic anion transporter 1 (OAT1) 351: Increased Mortality and 361: Decline, Population 1.29
405 Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function SAROJ AMAR Under development: Not open for comment. Do not cite 12: Acetylcholinesterase (AchE) Inhibition 402: Cognitive Function, Decreased
31 Oxidation of iron in hemoglobin leading to hematotoxicity Mitchell S. Wilbanks Open for adoption Included in OECD Work Plan 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) 321: N/A, Cyanosis occurs Under Development 1.16
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk Open for comment. Do not cite Included in OECD Work Plan 1634: Increase, Oxidative damage to DNA 185: Increase, Mutations and 1636: Increase, Chromosomal aberrations EAGMST Under Review 1.76
411 Oxidative stress [MIE] Leading to Decreased Lung Function [AO] Karsta Luettich Under development: Not open for comment. Do not cite
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Annie Jarabek Under development: Not open for comment. Do not cite Under Development
192 Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1155: Inhibition, Pendrin 1101: Altered, Amphibian metamorphosis 1.29
149 Peptide Oxidation Leading to Hypertension Frazer Lowe Not under active development Included in OECD Work Plan 209: Peptide Oxidation 952: Hypertension Under Development 1.50
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno Not under active development Included in OECD Work Plan 245: Activation, PXR/SXR Under Development 2.5
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development 231: Decreased, PPAR-alpha activation and 232: Decreased, PPAR-beta activation and 233: Decreased, PPAR-gamma activation 459: Increased, Liver Steatosis 1.29
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi Under development: Not open for comment. Do not cite Included in OECD Work Plan 1270: Inactivation of PPARγ 1276: Lung fibrosis Under Development 1.54
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi Under development: Not open for comment. Do not cite Under Development 1291: Hepatotoxicity
130 Phospholipase A inhibitors lead to hepatotoxicity Jung-Hwa Oh Under Development: Contributions and Comments Welcome Included in OECD Work Plan 828: Inhibition, Phospholipase A 840: Formation, Liver fibrosis Under Development 1.39
371 Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone You Song Under development: Not open for comment. Do not cite
369 Photosystem II antagonism leading to growth inhibition via oxidative damage You Song Under development: Not open for comment. Do not cite
370 Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis You Song Under development: Not open for comment. Do not cite
166 PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Charles Wood Under Development: Contributions and Comments Welcome Under Development 1063: Increased, Pancreatic acinar tumors 1.29
323 PPARalpha Agonism Impairs Fish Reproduction Ashley Kittelson Under development: Not open for comment. Do not cite 227: Activation, PPARα
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Charles Wood Under Development: Contributions and Comments Welcome Under Development 1028: Activation of specific nuclear receptors, PPAR-gamma activation 1.29
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard Open for citation & comment Included in OECD Work Plan 227: Activation, PPARα 406: impaired, Fertility and 348: Malformation, Male reproductive tract EAGMST Under Review 1.21
37 PPARα activation leading to hepatocellular adenomas and carcinomas in rodents Chris Corton Under development: Not open for comment. Do not cite Included in OECD Work Plan 227: Activation, PPARα 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.17
51 PPARα activation leading to impaired fertility in adult male rodents Elise Grignard Not under active development Included in OECD Work Plan 227: Activation, PPARα 406: impaired, Fertility Under Development 1.21
230 presynaptic neuron 1 activation to epilepsy Lyle Burgoon Open for adoption Under Development 1349: Activated, presynaptic neuron 1 1363: Increased, epilepsy
231 presynaptic neuron 2 repression to epilepsy Lyle Burgoon Open for adoption Under Development 1413: Reduced, presynaptic neuron 2 activity 1363: Increased, epilepsy
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development 798: Inhibition, Prolyl hydroxylases 78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory 1.29
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann Open for citation & comment Included in OECD Work Plan 244: Alkylation, Protein 344: N/A, Liver fibrosis TFHA/WNT Endorsed 1.14
185 Queen egg-laying decrease leads to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 563: Death/Failure, Colony 1.29
282 Reactive oxygen species generated from photoreactive chemicals leading to phototoxic reactions Satomi Onoue Under development: Not open for comment. Do not cite Included in OECD Work Plan 1592: ROS generation from photoactivated chemicals 1599: Inflamatory events in light-exposed tissues EAGMST Under Review 1.49
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite Included in OECD Work Plan 1486: Binding of substrate, endocytic receptor 814: Occurrence, Kidney toxicity Under Development 1.43
321 Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker Under development: Not open for comment. Do not cite
245 Reduction in photophosphorylation leading to growth inhibition in aquatic plants Knut Erik Tollefsen Under development: Not open for comment. Do not cite 1471: Increase, Uncoupling of photophosphorylation 1521: Decrease, Growth
258 Renal protein alkylation leading to kidney toxicity Angela Mally Not under active development Included in OECD Work Plan 244: Alkylation, Protein 814: Occurrence, Kidney toxicity Under Development 1.43
410 Repression of Gbx2 expression leads to defects in developing inner ear and consequently to increased mortality Vid Modic Under development: Not open for comment. Do not cite
342 S-adenosylmethionine depletion leading to population decline (1) You Song Under development: Not open for comment. Do not cite 1522: Inhibition, Chitin synthase 1 350: Increase, Mortality
343 S-adenosylmethionine depletion leading to population decline (2) You Song Under development: Not open for comment. Do not cite 1525: Increase, Sulfonylurea receptor binding 350: Increase, Mortality
406 SARS-CoV-2 infection leading to hyperinflammation Hasmik Yepiskoposyan Under development: Not open for comment. Do not cite
394 Sars-cov-2 infection leading to impaired olfactory function (anosmia) Sandra Coecke Under development: Not open for comment. Do not cite 1739: ACE2 binding to viral S-protein 1873: impaired olfactory function (anosmia)
407 SARS-CoV-2 infection leading to pyroptosis Hasmik Yepiskoposyan Under development: Not open for comment. Do not cite
412 SARS-CoV-2 infection leading to thromboinflammation Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite
237 Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Sarah Søs Poulsen Under development: Not open for comment. Do not cite Included in OECD Work Plan 1437: Sensing of the stressor by pulmonary cells 1443: Plaque progression in arteries Under Development 1.55
259 Sensitization induction of the intestinal tract by food proteins Erwin Roggen Under development: Not open for comment. Do not cite
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Timothy Allen Not under active development Under Development 1431: Serotonin 1A Receptor Agonism 1432: Anti-depressant Activity
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Timothy Allen Not under active development Under Development 1431: Serotonin 1A Receptor Agonism 1432: Anti-depressant Activity
225 Serotonin transporter activation to agitation Lyle Burgoon Open for adoption Under Development 1345: Increased, agitation
224 Serotonin transporter activation to depression Lyle Burgoon Open for adoption Under Development 1397: Increased, serotonin transporter activity 1346: Increased, depression
223 Serotonin transporter activation to seizure Lyle Burgoon Open for adoption Under Development 1397: Increased, serotonin transporter activity 1344: Increased, seizure
197 Sodium channel (Nav1.1) inhibition leading to population decline Kellie Fay Under Development: Contributions and Comments Welcome Under Development 584: Inhibition, sodium channel 1.29
94 Sodium channel inhibition leading to congenital malformations Kellie Fay Under Development: Contributions and Comments Welcome Under Development 584: Inhibition, sodium channel 591: Increased, amputations 1.29
93 sodium channel inhibition leading to increased predation Kellie Fay Under Development: Contributions and Comments Welcome Under Development 584: Inhibition, sodium channel 588: Increased, predation 1.29
91 Sodium channel inhibition leading to reduced survival Kellie Fay Under Development: Contributions and Comments Welcome Under Development 584: Inhibition, sodium channel 587: Reduced, feeding 1 and 588: Increased, predation and 592: Reduced, survival 1.29
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert Under Development: Contributions and Comments Welcome Under Development 424: Inhibition, Na+/I- symporter (NIS) 402: Cognitive Function, Decreased 1.29
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 424: Inhibition, Na+/I- symporter (NIS) 1101: Altered, Amphibian metamorphosis 1.29
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon Open for adoption Under Development 1317: Decreased, serotonin transporter activity 1343: Increase, hypertension
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Hiroyuki Komatsu Under development: Not open for comment. Do not cite Included in OECD Work Plan 1706: Stimulation, TLR7/8 1709: Psoriatic skin disease Under Development 1.75
173 Substance interaction with the lung resident cell membrane components leading to lung fibrosis Sabina Halappanavar Under development: Not open for comment. Do not cite Included in OECD Work Plan 1495: Interaction with the lung resident cell membrane components 1458: Pulmonary fibrosis EAGMST Under Review 1.32
361 Sulfonylureareceptor binding leading to mortality Simon Schmid Under development: Not open for comment. Do not cite 1525: Increase, Sulfonylurea receptor binding 350: Increase, Mortality
85 Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development 572: Decrease, Number of worker bees and 563: Death/Failure, Colony 1.29
84 Suppression of immune system contributes to impaired development and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development 572: Decrease, Number of worker bees and 568: impaired, Hive thermoregulation and 563: Death/Failure, Colony 1.29
41 Sustained AhR Activation leading to Rodent Liver Tumours Rick Becker Open for citation & comment Included in OECD Work Plan 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 856: Formation, Hepatocellular and Bile duct tumors EAGMST Under Review 1.7
304 TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee Under development: Not open for comment. Do not cite 1680: Inhibition, TBX1 1685: Anomalies, Congenital cardiac conotruncal
375 test AOP Kevin Crofton Under development: Not open for comment. Do not cite
324 Thermal stress leading to population decline (1) You Song Under development: Not open for comment. Do not cite 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
325 Thermal stress leading to population decline (2) You Song Under development: Not open for comment. Do not cite 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
326 Thermal stress leading to population decline (3) You Song Under development: Not open for comment. Do not cite 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
402 Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain Katherine (Katie) O'Shaughnessy Under development: Not open for comment. Do not cite
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton Under development: Not open for comment. Do not cite Included in OECD Work Plan 1656: Antagonism, Thyroid Receptor 402: Cognitive Function, Decreased Under Development 1.84
175 Thyroperoxidase inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 279: Thyroperoxidase, Inhibition 1101: Altered, Amphibian metamorphosis 1.29
365 Thyroperoxidase inhibition leading to increased mortality via altered photoreceptor patterning Lucia Vergauwen Under development: Not open for comment. Do not cite 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
363 Thyroperoxidase inhibition leading to increased mortality via altered retinal layer structure Lucia Vergauwen Under development: Not open for comment. Do not cite 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
364 Thyroperoxidase inhibition leading to increased mortality via decreased eye size Lucia Vergauwen Under development: Not open for comment. Do not cite 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
159 Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen Open for adoption Included in OECD Work Plan 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory EAGMST Under Review 1.35
347 Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Seokjoo Yoon Under development: Not open for comment. Do not cite 1792: Toll-like receptor 4 activation and 1270: Inactivation of PPARγ 1458: Pulmonary fibrosis
316 Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada Under development: Not open for comment. Do not cite Included in OECD Work Plan 1720: Trypsin inhibition 1725: Pancreatic acinar cell tumors Under Development 1.60
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1009: Inhibition, Deiodinase 1 1101: Altered, Amphibian metamorphosis 1.29
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1002: Inhibition, Deiodinase 2 1101: Altered, Amphibian metamorphosis 1.29
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1153: Inhibition, Deiodinase 3 1101: Altered, Amphibian metamorphosis 1.29
263 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation You Song Open for comment. Do not cite Included in OECD Work Plan 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased lipid storage You Song Under development: Not open for comment. Do not cite Included in OECD Work Plan 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
264 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cell death You Song Under development: Not open for comment. Do not cite Included in OECD Work Plan 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased lipid peroxidation You Song Under development: Not open for comment. Do not cite Included in OECD Work Plan 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
268 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased protein oxidation You Song Under development: Not open for comment. Do not cite Included in OECD Work Plan 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition via oxidative DNA damage You Song Under development: Not open for comment. Do not cite Included in OECD Work Plan 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
186 unknown MIE leading to renal failure and mortality Kellie Fay Under Development: Contributions and Comments Welcome Under Development 1114: Unknown, MIE 351: Increased Mortality 1.29
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development 801: modulation, Unknown 78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory 1.29
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Not under active development Included in OECD Work Plan 239: Activation, Pregnane-X receptor, NR1l2 319: Loss, Cochlear function Under Development 1.9
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development 793: Increase, Urinary bladder calculi 797: Increase, Adenomas/carcinomas (urothelial) 1.29
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 563: Death/Failure, Colony 1.29
179 Varroa mite infestation increases virus levels leading to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 563: Death/Failure, Colony 1.29
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Jeanelle Martinez Under development: Not open for comment. Do not cite Under Development 1215: TRPA1 activation, TRPA1 Receptor 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea and 1434: Irritation of nasal mucosa inducing sneeze reflex and 1226: Increased Respiratory irritability and Chronic Cough,
182 Weather event contributes abnormal foraging leading to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 563: Death/Failure, Colony 1.29
181 Weather event contributes to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 563: Death/Failure, Colony 1.29
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Tammy Stoker Under Development: Contributions and Comments Welcome Under Development 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase 527: Decreased, Decreased fecundity 1.29
280 α-diketone-induced bronchiolitis obliterans Marvin Martens Under development: Not open for comment. Do not cite 1584: Interaction of α-diketones with arginine residues 1588: Bronchiolitis obliterans