AOPs

ID	Title	Point of Contact	License	MIE	AO	OECD Status	OECD Project
443	DNA damage and mutations leading to Metastatic Breast Cancer	Usha Adiga	BY-SA	Increased, DNA damage and mutation	metastatic breast cancer	Under Development	1.103
450	Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality	SAROJ AMAR	BY-SA	Acetylcholinesterase (AchE) Inhibition	Sensory axonal peripheral neuropathy Increased Mortality
202	Inhibitor binding to topoisomerase II leading to infant leukaemia	Andrea Terron	BY-SA	Binding to (interferes with) topoisomerase II enzyme	Infant leukaemia	WPHA/WNT Endorsed	1.53
389	Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis	Knut Erik Tollefsen	BY-SA	Increase, Oxygen-evolving complex damage	Decrease, Reproduction Decrease, Population growth rate
423	Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway	Fei Li	BY-SA	Activation, PARP1 ROS formation	Apoptotic cell death
98	5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation	Ksenia Groh	BY-SA	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Increased, predation		1.29
97	5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline	Kellie Fay	BY-SA	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Increase, predation Decrease, Population growth rate		1.29
195	5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase	Kellie Fay	BY-SA	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Increased, Population		1.29
203	5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline	Kellie Fay	BY-SA	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Decreased, Reproductive Success Decrease, Population growth rate		1.29
204	5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase	Kellie Fay	BY-SA	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Increased, Reproductive Success Increased, Population		1.29
305	5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring	Terje Svingen	BY-SA	Inhibition, 5α-reductase	anogenital distance (AGD), decreased	Under Development	1.90
429	A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants	Erwin L Roggen	BY-SA		Memory Loss
82	Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure	Carlie LaLone	BY-SA		impaired, Larval development Death/Failure, Colony		1.29
427	ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.	Evangelos-Panagiotis Daskalopoulos	BY-SA	Binding to ACE2	Heart failure
16	Acetylcholinesterase inhibition leading to acute mortality	Dan Villeneuve	BY-SA	Acetylcholinesterase (AchE) Inhibition	Increased Mortality Decrease, Population growth rate	Under Development	1.3
312	Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement	Kristie Sullivan	BY-SA	Acetylcholinesterase (AchE) Inhibition	Increased Mortality Decrease, Population growth rate
281	Acetylcholinesterase Inhibition Leading to Neurodegeneration	Karen Watanabe	BY-SA	Acetylcholinesterase (AchE) Inhibition	N/A, Neurodegeneration
210	Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building	Jinhee Choi	All rights reserved		Reproductive failure
499	Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release	Travis Karschnik	All rights reserved	Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2	Impairment, Learning and memory
500	Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis	Travis Karschnik	All rights reserved	Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2	Impairment, Learning and memory
462	Activation of reactive oxygen species leading the atherosclerosis	Hiromi Ohara	BY-SA
439	Activation of the AhR leading to breast cancer	Louise Benoit	BY-SA	Activation, AhR	N/A, Breast Cancer	Under Development	1.105
503	Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation	Barbara Viviani	BY-SA	Activation, estrogen receptor alpha	Uterine adenocarcinoma (endometrioid adenocarcinoma Type I)
452	Adverse outcome pathway of PM-induced respiratory toxicity	li qing	BY-SA	Non-coding RNA expression profile alteration	Chronic obstructive pulmonary disease
282	Adverse outcome pathway on photochemical toxicity initiated by light exposure	Satomi Onoue	BY-SA	ROS generation from photoactivated chemicals	Inflamatory events in light-exposed tissues	EAGMST Under Review	1.49
476	Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity	Yue Zhang	All rights reserved	Increased, Reactive oxygen species Disruption, Estrogen receptor Antagonism, Androgen receptor	Decreased sperm quantity or quality in the adult, Decreased fertility anogenital distance (AGD), decreased Malformation, cryptorchidism - maldescended testis Decrease, Reproduction
46	AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)	Ted Simon	BY-SA	Formation, Pro-mutagenic DNA Adducts	Tumorigenesis, Hepatocellular carcinoma	EAGMST Under Review	1.8
458	AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Prakash Patel	BY-SA	Activation, AhR	Cognitive Function, Decreased
459	AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Prakash Patel	BY-SA	Activation, AhR	Cognitive Function, Decreased
57	AhR activation leading to hepatic steatosis	Michelle Angrish	BY-SA	Activation, AhR	Accumulation, Liver lipid		1.29
494	AhR activation leading to liver fibrosis	Xavier COUMOUL	All rights reserved	Activation, AhR	N/A, Liver fibrosis
151	AhR activation leading to preeclampsia	Sabrina Tait	All rights reserved	Activation, AhR	increase, Preeclampsia	Under Development	1.42
62	AKT2 activation leading to hepatic steatosis	Michelle Angrish	BY-SA	systemic inflammation leading to hepatic steatosis	Increased, Liver Steatosis		1.29
465	Alcohol dehydrogenase leading to reproductive dysfunction	Donggon Yoo	BY-SA	Increase, Alcohol dehydrogenase
15	Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations	Carole Yauk	BY-SA	Alkylation, DNA	Increase, Heritable mutations in offspring	WPHA/WNT Endorsed	1.11
139	Alkylation of DNA leading to cancer 1	Carole Yauk	Open for adoption	Alkylation, DNA	Increase, Cancer
322	Alkylation of DNA leading to reduced sperm count	Carole Yauk	BY-SA	Alkylation, DNA	Reduce, Sperm count
126	Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation	Tammy Stoker	BY-SA	Inhibition, Antgonism of NE receptor	Decreased, Decreased fecundity		1.29
105	Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)	Charles Wood	BY-SA	Increased, Binding of chemicals to 2u (serum)	Increase, Adenomas/carcinomas (renal tubular)		1.29
104	Altered ion channel activity leading impaired heart function	Kevin Dreher	BY-SA	impaired, ion channels	Increased Mortality		1.29
515	An overview of adverse outcome pathway linked between PM2.5 exposure and congenital heart defects	Liang Chen	All rights reserved
345	Androgen receptor (AR) antagonism leading to decreased fertility in females	Terje Svingen	BY-SA	Antagonism, Androgen receptor	Decreased fertility, Reduced number of oocytes ovulated	Under Development	1.109
477	Androgen receptor (AR) antagonism leading to hypospadias in male offspring	Terje Svingen	BY-SA	Antagonism, Androgen receptor	Hypospadias, increased
344	Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring	Terje Svingen	BY-SA	Antagonism, Androgen receptor	Nipple retention (NR), increased	Under Development	1.108
306	Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring	Terje Svingen	BY-SA	Antagonism, Androgen receptor	anogenital distance (AGD), decreased	Under Development	1.90
117	Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)	Charles Wood	Open for adoption	Activation, Androgen receptor	Increase, hepatocellular adenomas and carcinomas	Under Development	1.26
495	Androgen receptor activation leading to prostate cancer	Jianxiang Li	All rights reserved	Activation, Androgen receptor	Prostate cancer
376	Androgen receptor agonism leading to male-biased sex ratio	Dan Villeneuve	BY-SA	Agonism, Androgen receptor	Decrease, Population growth rate	WPHA/WNT Endorsed	1.12
496	Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）	xuan liu	BY-SA	Agonism, Androgen receptor Increased, gene expression of AR	Decreased, Population trajectory
23	Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)	Dan Villeneuve	BY-SA	Agonism, Androgen receptor	Decrease, Population growth rate	WPHA/WNT Endorsed	1.12
19	Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)	Mukesh Patel	Open for adoption	N/A, Androgen receptor, Antagonism	N/A, Impairment of reproductive capacity
372	Androgen receptor antagonism leading to testicular cancer	Chander K. Negi	BY-SA	Antagonism, Androgen receptor	Testicular Cancer
382	Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis	Young Jun Kim	BY-SA	Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)	Lung fibrosis	Under Development	1.96
460	Antagonism of Smoothened receptor leading to orofacial clefting	Jacob Reynolds	All rights reserved	Antagonism, Smoothened receptor	Orofacial clefting	Under Development	1.101
6	Antagonist binding to PPARα leading to body-weight loss	Kurt A. Gust	BY-SA	Binding of antagonist, PPAR alpha	Decreased, Body Weight	WPHA/WNT Endorsed	2.3
170	Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat	Charles Wood	BY-SA		Increased, Adenomas/carcinomas (mammary)		1.29
187	Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage	Barnett Rattner	BY-SA	Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin	Impaired recruitment , Population trajectory	Under Development	1.31
165	Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse	Charles Wood	BY-SA		Promotion, ovarian adenomas Promotion, ovarian granular cell tumors		1.29
393	AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation	Fei Li	BY-SA	Increased, Hepatic thyroid hormone uptake/transport
335	AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment	Nathalia Pereira Souza	BY-SA	Mitochondrial impairment	Urothelial Tumor
205	AOP from chemical insult to cell death	Mathieu Vinken	BY-SA	Decompartmentalization Direct mitochondrial inhibition narcosis	Apoptosis Necrosis
481	AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.	Hailin Xu	BY-SA	Increase, Reactive oxygen species	Increased incidence of respiratory disease Dysfunction of respiratory system
7	Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female	Elise Grignard	BY-SA	reduction in ovarian granulosa cells, Aromatase (Cyp19a1)	impaired, Fertility irregularities, ovarian cycle	EAGMST Under Review	1.21
153	Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats	Tammy Stoker	BY-SA	Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol	Decreased fertility, Reduced number of oocytes ovulated		1.29
25	Aromatase inhibition leading to reproductive dysfunction	Dan Villeneuve	BY-SA	Inhibition, Aromatase	Decrease, Population growth rate	WPHA/WNT Endorsed	1.12
346	Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation	Kelvin Santana Rodriguez	BY-SA	Inhibition, Aromatase	Decrease, Population growth rate	WPHA/WNT Endorsed	1.12
456	Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity	Prarthana Shankar	BY-SA	Activation, AhR	Increase, Early Life Stage Mortality	EAGMST Under Review
455	Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development	Prarthana Shankar	BY-SA	Activation, AhR	Increase, Early Life Stage Mortality Facial cartilage structures are reduced in size and morphologically distorted	EAGMST Under Review
21	Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2	Markus Hecker	BY-SA	Activation, AhR		WPHA/WNT Endorsed	1.27
150	Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF	Amani Farhat	BY-SA	Activation, AhR	Increase, Early Life Stage Mortality	WPHA/WNT Endorsed	1.7
418	Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway	Dianke Yu	All rights reserved
419	Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway	Dianke Yu	All rights reserved		Decrease, Lung function
417	Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway	Dianke Yu	All rights reserved	Activation, AhR	Lung cancer
416	Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway	Dianke Yu	All rights reserved	Activation, AhR	Lung cancer
420	Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway	Dianke Yu	All rights reserved	Activation, AhR
415	Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway	Dianke Yu	All rights reserved	Activation, AhR	Lung fibrosis
414	Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway	Dianke Yu	All rights reserved	Activation, AhR
131	Aryl hydrocarbon receptor activation leading to uroporphyria	Amani Farhat	BY-SA	Activation, AhR	Uroporphyria	WPHA/WNT Endorsed	1.7
96	Axonal sodium channel modulation leading to acute mortality	Kellie Fay	BY-SA	modulation, sodium channel	Increased Mortality		1.29
164	Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse	Charles Wood	BY-SA	Activation, beta-2 adrenergic receptor	Promotion, mesovarian leiomyomas		1.29
48	Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.	Anna Price	BY-SA	Binding of agonist, Ionotropic glutamate receptors	Impairment, Learning and memory	WPHA/WNT Endorsed	1.23
475	Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons	Shihori Tanabe	All rights reserved	Binding of agonist, Ionotropic glutamate receptors	Impairment, Learning and memory	Under Development	1.107
17	Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory	Marie-Gabrielle Zurich	BY-SA	Binding, Thiol/seleno-proteins involved in protection against oxidative stress	Impairment, Learning and memory	WPHA/WNT Endorsed	1.13
284	Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease	Frederic Y. Bois	BY-SA	Binding, Thiol/seleno-proteins involved in protection against oxidative stress	Chronic kidney disease
506	Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation	Jessica Resnick	All rights reserved	Influenza A Virus (IAV) binds sialic acid glycan receptor	Influenza A Virus (IAV) shedding and transmission
428	Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis	Laure-Alix Clerbaux	BY-SA	Binding to ACE2		Under Development	1.96
374	Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis	Anna Price	All rights reserved	Binding to ACE2	Encephalitis	Under Development	1.96
395	Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)	Magda Sachana	BY-SA	Binding to ACE2	Cerebrovascular disease (stroke)	Under Development	1.96
422	Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption	Laure-Alix Clerbaux	BY-SA	Binding to ACE2		Under Development	1.96
468	Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)	Laure-Alix Clerbaux	BY-SA	Binding to ACE2	Hyperinflammation
430	Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation	Sally Mayasich	All rights reserved	Binding to ACE2	Viral infection and host-to-host transmission, proliferated	Under Development	1.96
320	Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality	Young Jun Kim	BY-SA	Binding to ACE2	Increased Mortality	Under Development	1.96
381	Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia	Young Jun Kim	BY-SA	Binding to ACE2	dysgeusia	Under Development	1.96
319	Binding to ACE2 leading to lung fibrosis	Young Jun Kim	BY-SA	Induced dysregulation of ACE2	Lung fibrosis	Under Development	1.96
379	Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation	Shihori Tanabe	All rights reserved	Binding to ACE2	Thrombosis and Disseminated Intravascular Coagulation	Under Development	1.96
314	Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)	Yasuharu Otsubo	BY-SA	Binding to estrogen receptor (ER)-α in immune cells	Exacerbation of systemic lupus erythematosus (SLE)	Under Development	1.73
486	Binding to the extracellular protein laminin leading to decreased cognitive function	Eliska Kuchovska	BY-SA	Binding, extracellular matrix protein laminin	Cognitive Function, Decreased
10	Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain	Ping Gong	BY-SA	Binding at picrotoxin site, iGABAR chloride channel	Occurrence, Epileptic seizure	WPHA/WNT Endorsed	1.15
442	Binding to voltage gate sodium channels during development leads to cognitive impairment	Iris Mangas	BY-SA	Binding to voltage-gated sodium channel	Impairment, Learning and memory	Under Development	1.91
484	Bisphenol A analogs induce cellular dysfunction in human trophoblast cells in a thyroid hormone receptor-dependent manner: in silico and in vitro analyses	Xiaoyun Wu	BY-SA
397	Bulky DNA adducts leading to mutations	Carole Yauk	BY-SA	Bulky DNA adducts, increase	Increase, Mutations	Under Development	1.11
464	Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits	Julia Meerman	All rights reserved	Activation of metabotropic glutamate receptor Inositol triphosphate receptor activation Overactivation, NMDARs Inhibition GABAA receptor Opening, voltage-gated calcium channels	Parkinsonian motor deficits
26	Calcium-mediated neuronal ROS production and energy imbalance	Lyle Burgoon	Open for adoption	Inhibition, Ca++ ATPase	Increased, Oxidative damage
449	Ceramide synthase inhibition leading to neural tube defects	Lola Bajard	BY-SA	Inhibition of Ceramide Synthase	Neural tube defects
106	Chemical binding to tubulin in oocytes leading to aneuploid offspring	Francesco Marchetti	BY-SA	Binding, Tubulin	Increase, Aneuploid offspring	EAGMST Under Review	1.11
360	Chitin synthase 1 inhibition leading to mortality	Simon Schmid	BY-SA	Inhibition, Chitin synthase 1	Increase, Mortality	WPHA/WNT Endorsed	1.94
358	Chitinase inhibition leading to mortality	Simon Schmid	All rights reserved	Inhibition, Chitinase	Increase, Mortality	Under Development	1.94
359	Chitobiase inhibition leading to mortality	Simon Schmid	All rights reserved	Inhibition, Chitobiase	Increase, Mortality	Under Development	1.94
27	Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)	Mathieu Vinken	BY-SA	Inhibition, Bile Salt Export Pump (ABCB11)	Cholestasis, Pathology	Under Development	1.19
13	Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities	Anna Price	BY-SA	Binding of antagonist, NMDA receptors	Impairment, Learning and memory	WPHA/WNT Endorsed	1.22
12	Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging	Florianne Tschudi-Monnet	BY-SA	Binding of antagonist, NMDA receptors	N/A, Neurodegeneration Impairment, Learning and memory	WPHA/WNT Endorsed	1.13
118	Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)	Charles Wood	BY-SA	Increase, Cytotoxicity (hepatocytes)	Increase, hepatocellular adenomas and carcinomas		1.29
171	Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.	Charles Wood	BY-SA		Increased, mesotheliomas		1.29
490	Co-activation of IP3R and RyR leads to economic burden through reduced IQ and non-cholinergic mechanisms	Karine Audouze	All rights reserved	Ryanodine receptor activation Inositol triphosphate receptor activation	Impairment, Learning and memory decreased, Intellectual Quotient increased, Economic Burden
403	combined unhealthy lifestyle factors leading to metabolic syndrome	Gillina Bezemer	BY-SA
367	Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	Binding, Thyroid binding globulin in serum	Altered, Amphibian metamorphosis
366	Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	Binding, Transthyretin in serum	Altered, Amphibian metamorphosis
107	Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat	Kristin Lichti-Kaiser	BY-SA	Activation, Constitutive androstane receptor	Increase, hepatocellular adenomas and carcinomas	EAGMST Under Review	1.17
39	Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response	Jessica Ponder	BY-SA	Covalent Binding, Protein	Increase, Allergic Respiratory Hypersensitivity Response	Under Development	1.20
40	Covalent Protein binding leading to Skin Sensitisation	Sharon Munn	BY-SA	Covalent Binding, Protein	sensitisation, skin	WPHA/WNT Endorsed	1.1
177	Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality	Kellie Fay	BY-SA	Inhibition, Cyclooxygenase 1 activity	Increased Mortality Decrease, Population growth rate		1.29
28	Cyclooxygenase inhibition leading reproductive failure	Dan Villeneuve	BY-SA	Inhibition, Cyclooxygenase activity	N/A, Reproductive failure		1.29
63	Cyclooxygenase inhibition leading to reproductive dysfunction	Dalma Martinovic-Weigelt	BY-SA	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate		1.29
100	Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior	Dalma Martinovic-Weigelt	BY-SA	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate		1.29
101	Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release	Dalma Martinovic-Weigelt	BY-SA	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate		1.29
102	Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition	Dalma Martinovic-Weigelt	BY-SA	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate		1.29
103	Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint	Dalma Martinovic-Weigelt	BY-SA	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate		1.29
434	CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects	Job Berkhout	All rights reserved
260	CYP2E1 activation and formation of protein adducts leading to neurodegeneration	Jelle Broeders	BY-SA	CYP2E1 Activation Protein Adduct Formation	Neurodegeneration
220	Cyp2E1 Activation Leading to Liver Cancer	Francina Webster	BY-SA	Activation of Cyp2E1	Liver Cancer	WPHA/WNT Endorsed	1.24
368	Cytochrome oxidase inhibition leading to olfactory nasal lesions	Katy Goyak	BY-SA	Inhibition, cytochrome oxidase	Increase, Site of Contact Nasal Tumors
109	Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)	Charles Wood	BY-SA	Increase, Cytotoxicity (club cells)	Increase, Adenomas/carcinomas (bronchioloalveolar)		1.29
116	Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)	Charles Wood	BY-SA	Increase, Cytotoxicity (tubular epithelial cells)	Increase, Adenomas/carcinomas (renal tubular)		1.29
86	Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure	Carlie LaLone	BY-SA		impaired, Larval development Death/Failure, Colony		1.29
111	Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)	Charles Wood	BY-SA	Decreased, Androgen receptor activity	Increase, Leydig cell tumors		1.29
502	Decrease, cholesterol synthesis leads to orofacial clefting	Jacob Reynolds	All rights reserved		Orofacial clefting	Under Development	1.101
491	Decrease, GLI1/2 target gene expression leads to orofacial clefting	Jacob Reynolds	All rights reserved	Decrease, GLI1/2 target gene expression	Orofacial clefting	Under Development	1.101
392	Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation	Penny Nymark	BY-SA	Fibrinolysis, decreased Bradykinin system, hyperactivated	Hyperinflammation	Under Development	1.96
307	Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring	Terje Svingen	BY-SA		anogenital distance (AGD), decreased	Under Development	1.90
158	Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation	Dries Knapen	BY-SA	Inhibition, Deiodinase 1	Increased Mortality Decrease, Population growth rate	WPHA/WNT Endorsed	1.35
157	Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation	Dries Knapen	BY-SA	Inhibition, Deiodinase 1	Increased Mortality Decrease, Population growth rate	WPHA/WNT Endorsed	1.35
156	Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation	Dries Knapen	BY-SA	Inhibition, Deiodinase 2	Increased Mortality Decrease, Population growth rate	WPHA/WNT Endorsed	1.35
155	Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation	Dries Knapen	BY-SA	Inhibition, Deiodinase 2	Increased Mortality Decrease, Population growth rate	WPHA/WNT Endorsed	1.35
510	Demethylation of PPAR promotor leading to vascular disrupting effects	Yanhong Wei	All rights reserved	peroxisome proliferator activated receptor promoter demethylation	Increase, Vascular disrupting effects
432	Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia	Dag Anders Brede	All rights reserved	Deposition of Energy	Acute Myeloid Leukemia
483	Deposition of Energy Leading to Learning and Memory Impairment	Vinita Chauhan	All rights reserved	Deposition of Energy	Impairment, Learning and memory
272	Deposition of energy leading to lung cancer	Vinita Chauhan	BY-SA	Deposition of Energy	Increase, lung cancer	WPHA/WNT Endorsed	1.56
482	Deposition of energy leading to occurrence of bone loss	Vinita Chauhan	All rights reserved	Deposition of Energy	Occurrence, Bone Loss
478	Deposition of energy leading to occurrence of cataracts	Vinita Chauhan	All rights reserved	Deposition of Energy	Occurrence of Cataracts
299	Deposition of energy leading to population decline via DNA oxidation and follicular atresia	You Song	BY-SA	Deposition of Energy	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
311	Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis	You Song	BY-SA	Deposition of Energy	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
216	Deposition of energy leading to population decline via DNA strand breaks and follicular atresia	Knut Erik Tollefsen	BY-SA	Deposition of Energy	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
238	Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis	Knut Erik Tollefsen	BY-SA	Deposition of Energy	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
470	Deposition of energy leads to vascular remodeling	Vinita Chauhan	All rights reserved	Deposition of Energy	Occurrence, Vascular Remodeling
388	Deposition of ionising energy leading to population decline via programmed cell death	Knut Erik Tollefsen	BY-SA	Deposition of Energy	Decrease, Reproduction Decrease, Population growth rate
387	Deposition of ionising energy leading to population decline via mitochondrial dysfunction	Knut Erik Tollefsen	BY-SA	Deposition of Energy	Decrease, Reproduction Decrease, Population growth rate
461	Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis	Knut Erik Tollefsen	BY-SA
435	Deposition of ionising energy leads to population decline via pollen abnormal	Li Xie	BY-SA	Deposition of Energy	Decrease, Reproduction Decreased, Population trajectory
386	Deposition of ionizing energy leading to population decline via inhibition of photosynthesis	Knut Erik Tollefsen	BY-SA	Deposition of Energy	Decrease, Reproduction Decrease, Population growth rate
396	Deposition of ionizing energy leads to population decline via impaired meiosis	Erica Maremonti	All rights reserved	Deposition of Ionizing Energy	Decrease of egg production and cummulative fecundity Decrease, Reproduction Decreased, Population size
43	Disruption of VEGFR Signaling Leading to Developmental Defects	Tom Knudsen	BY-SA	Inhibition, VegfR2	Increased, Developmental Defects	WPHA/WNT Endorsed	1.6
472	DNA adduct formation leading to kidney failure	Manoe Janssen	BY-SA
240	DNA Adducts Leading to Liver Hemangiosarcoma	Annie Jarabek	BY-SA
336	DNA methyltransferase inhibition leading to population decline (1)	You Song	BY-SA	Increase, DNA methyltransferase inhibition	Decrease, Fecundity Decrease, Population growth rate
337	DNA methyltransferase inhibition leading to population decline (2)	You Song	BY-SA	Increase, DNA methyltransferase inhibition	Decrease, Fecundity Decrease, Population growth rate
338	DNA methyltransferase inhibition leading to population decline (3)	You Song	BY-SA	Increase, DNA methyltransferase inhibition	Decrease, Fecundity Decrease, Population growth rate
339	DNA methyltransferase inhibition leading to population decline (4)	You Song	BY-SA	Increase, DNA methyltransferase inhibition	Decrease, Fecundity Decrease, Population growth rate
340	DNA methyltransferase inhibition leading to transgenerational effects (1)	You Song	BY-SA	Increase, DNA methyltransferase inhibition	Decrease, Fecundity (F3) Decrease, Population growth rate
341	DNA methyltransferase inhibition leading to transgenerational effects (2)	You Song	BY-SA	Increase, DNA methyltransferase inhibition	Decrease, Fecundity (F3) Decrease, Population growth rate
466	Doda decarboxylase leading to mortality	Donggon Yoo	BY-SA	Decrease, Tyrosine
193	Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	Inhibition, Dual oxidase	Altered, Amphibian metamorphosis		1.29
377	Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)	Gillina Bezemer	BY-SA	Prolonged TLR9 activation	Multi Organ Failure involving Acute Respiratory Distress Syndrome Increased Mortality
378	Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load	Gillina Bezemer	BY-SA	Toll Like Receptor (TLR) Dysregulation
167	Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.	Charles Wood	BY-SA	prepubertal increase, Estrogen receptor (ER) activity	Increased, adenosquamous carcinomas of endometrium		1.29
295	Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk	Andrea Hindman	BY-SA			Under Development	1.79
4	Ecdysone receptor agonism leading to incomplete ecdysis associated mortality	Knut Erik Tollefsen	BY-SA	Increase, Ecdysone receptor agonism	Increase, Mortality
148	EGFR Activation Leading to Decreased Lung Function	Karsta Luettich	BY-SA	Activation, EGFR	Decrease, Lung function	Under Development	1.51
269	Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development	Christopher Goodchild	BY-SA
270	Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity	Christopher Goodchild	All rights reserved
310	Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR	Jon Doering	BY-SA	Activation, AhR	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
144	Endocytic lysosomal uptake leading to liver fibrosis	Marina Kuburic	BY-SA	Endocytotic lysosomal uptake	N/A, Liver fibrosis	EAGMST Under Review	1.47
412	Endothelial cell dysfunction leading to thromboinflammation	Luigi Margiotta-Casaluci	All rights reserved		Thromboinflammation, Increased	Under Development	1.96
473	Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin	Danielle Beaton	BY-SA	Deposition of Energy	Decrease, Growth Decreased, Reproductive Success
162	Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse	Charles Wood	BY-SA		Increase, Adenomas/carcinomas (follicular cell)		1.29
72	Epigenetic modification of PPARG leading to adipogenesis	Michelle Angrish	BY-SA	peroxisome proliferator activated receptor promoter demethylation chronic high fat diet	obesity		1.29
115	Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)	Charles Wood	BY-SA	Increase, Cytotoxicity (epithelial cells)	Increase, Papillomas/carcinomas (squamous cells)		1.29
53	ER agonism leading to reduced survival due to renal failure	Tom Hutchinson	BY-SA	Agonism, Estrogen receptor			1.29
52	ER agonism leading to skewed sex ratios due to altered sexual differentiation in males	Tom Hutchinson	BY-SA	Agonism, Estrogen receptor	skewed, sex ratio		1.29
199	ER mediated breast cancer AOP	Molly M Morgan	BY-SA
493	ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity	Min Ji Kim	All rights reserved	Estrogen receptor alpha inactivation	Metabolically unhealthy Obesity
497	ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome	Min Ji Kim	All rights reserved	Estrogen receptor alpha inactivation	Insulin resistance Metabolic syndrome
146	Estrogen Receptor Activation and Female Precocious Puberty	Jeff Welch	BY-SA				1.29
200	Estrogen receptor activation leading to breast cancer	Molly M Morgan	Open for adoption	Activation, Estrogen receptor	N/A, Breast Cancer
29	Estrogen receptor agonism leading to reproductive dysfunction	Tom Hutchinson	BY-SA	Agonism, Estrogen receptor	Decrease, Population growth rate Altered, Reproductive behaviour Altered, Larval development Impaired development of, Reproductive organs		1.29
445	Estrogen Receptor Alpha Agonism leads to Impaired Reproduction	John Hoang	BY-SA	Activation, estrogen receptor alpha	Impaired, Reproduction
30	Estrogen receptor antagonism leading to reproductive dysfunction	Dan Villeneuve	BY-SA	Antagonism, Estrogen receptor	Decrease, Population growth rate	EAGMST Under Review	1.12
95	Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival	Kellie Fay	BY-SA	Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel	Reduced, survival		1.29
501	Excessive iron accumulation leading to neurological disorders	Young Jun Kim	Open for adoption	Increased intracelluar Iron accumulation	Neurological disorder
327	Excessive reactive oxygen species production leading to mortality (1)	You Song	BY-SA	Increase, Reactive Oxygen Species production	Increase, Mortality
328	Excessive reactive oxygen species production leading to mortality (2)	You Song	BY-SA	Increase, Reactive Oxygen Species production	Increase, Mortality
329	Excessive reactive oxygen species production leading to mortality (3)	You Song	BY-SA	Increase, Reactive Oxygen Species production	Increase, Mortality
330	Excessive reactive oxygen species production leading to mortality (4)	You Song	BY-SA	Increase, Reactive Oxygen Species production	Increase, Mortality
331	Formation of DNA photoproducts leading to growth inhibition (1)	You Song	BY-SA	Increase, Formation of DNA photoproducts	Increase, Mortality
332	Formation of DNA photoproducts leading to growth inhibition (2)	You Song	BY-SA
333	Formation of DNA photoproducts leading to growth inhibition (3)	You Song	BY-SA
409	Frustrated phagocytosis leads to malignant mesothelioma	Penny Nymark	BY-SA	Frustrated phagocytosis	Increased, mesotheliomas
303	Frustrated phagocytosis-induced lung cancer	Carole Seidel	BY-SA	Frustrated phagocytosis	Lung cancer	Under Development	1.86
401	G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects	Fei Li	BY-SA	protein-coupled estrogen receptor 1 (GPER) activation	N/A, Steatohepatisis
217	Gastric ulcer formation	Lyle Burgoon	Open for adoption		Inhibit, gastric ulcer formation Activated, gastric ulcer formation
64	Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility	Susan Laws	BY-SA	Glucocorticoid Receptor Agonist, Activation	impaired, Fertility		1.29
318	Glucocorticoid Receptor activation leading to hepatic steatosis	Chander K. Negi	BY-SA	Activation, Glucocorticoid Receptor	Increased, Liver Steatosis
14	Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility	Carlie LaLone	BY-SA	Activation, Glucocorticoid Receptor	Increased, Disease susceptibility		1.29
334	Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration	Alexander Cole	BY-SA	Activation, Glucocorticoid Receptor	Decrease, Population growth rate
113	Glutamate-gated chloride channel activation leading to acute mortality	Helen Poynton	BY-SA	Activation, Glutamate-gated chloride channel	Increased Mortality Decreased, population 1		1.29
161	Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality	Knut Erik Tollefsen	BY-SA	Activation, Glutamate-gated chloride channels	Increased Mortality
492	Glutathione conjugation leading to reproductive dysfunction via oxidative stress	Leonardo Vieira	All rights reserved	Conjugation, GSH	impaired, Fertility
168	GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.	Charles Wood	BY-SA		Increased, Adenomas/carcinomas (mammary)		1.29
169	GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.	Charles Wood	BY-SA		Increased, adenomas (pituitary)		1.29
410	GSK3beta inactivation leading to increased mortality via defects in developing inner ear	Vid Modic	BY-SA	GSK3beta inactivation	Increased Mortality Decrease, Population growth rate
211	Handbook development AOP	Dan Villeneuve	BY-SA				1.29
229	Helicobacter pylori to gastric ulcer	Lyle Burgoon	Open for adoption	Helicobacter pylori infection	Activated, gastric ulcer formation
194	Hepatic nuclear receptor activation leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	Activation, Hepatic nuclear receptor(s)	Altered, Amphibian metamorphosis		1.29
433	hERG channel blockade leading to sudden cardiac death	Egemen Bilgin	BY-SA	hERG channel blockade	Sudden cardiac death
99	Histamine (H2) receptor antagonism leading to reduced survival	Kellie Fay	BY-SA	Antagonism, Histamine Receptor (H2)	Decreased, survival Increased, predation		1.29
212	Histone deacetylase inhibition leading to testicular atrophy	Shihori Tanabe	BY-SA	Histone deacetylase inhibition	Testicular atrophy	WPHA/WNT Endorsed	1.52
274	Histone deacetylase inhibition leads to impeded craniofacial development	Marvin Martens	BY-SA	Histone deacetylase inhibition	Facial cartilage structures are reduced in size and morphologically distorted
275	Histone deacetylase inhibition leads to neural tube defects	Marvin Martens	BY-SA	Histone deacetylase inhibition	Neural tube defects
124	HMG-CoA reductase inhibition leading to decreased fertility	Kellie Fay	BY-SA	Inhibition, HMG-CoA reductase	Decrease, Fertility		1.29
59	HNF4alpha suppression leading to hepatic steatosis	Michelle Angrish	BY-SA	Suppression, HNF4alpha			1.29
114	HPPD inhibition leading to corneal papillomas and carcinomas (in rat)	Charles Wood	BY-SA	Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme	Increase, Papillomas/carcinomas (squamous cells)		1.29
384	Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease	Young Jun Kim	BY-SA	Hyperactivation of ACE/Ang-II/AT1R axis	Chronic kidney disease
440	Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia	Kalyan Gayen	All rights reserved	Suppression, Estrogen receptor (ER) activity	Promotion, ovarian adenomas Promotion, Ovarian Cancer	Under Development	1.104
278	IKK complex inhibition leading to liver injury	Nanette Vrijenhoek	BY-SA	Inhibition, IKK complex	Necrotic Tissue Liver Injury
408	Imbalance in redox homeostasis leading to structural damage to tissues	Fei Li	BY-SA
362	Immune mediated hepatitis	Jung-Hwa Oh	BY-SA	benzoquinone imine and acylglucuronide metabolites	Immune mediated hepatitis
277	Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response	Takao Ashikaga	BY-SA	Impaired IL-1R1 signaling in T cell	Impairment, T-cell dependent antibody response	WPHA/WNT Endorsed	1.48
400	Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males	Terje Svingen	BY-SA	Increased (ectopic) all-trans retinoic acid concentration	Reduce, Sperm count
293	Increased DNA damage leading to increased risk of breast cancer	Jessica Helm	BY-SA	Increase, DNA damage	Increase, Mutations Increased, Ductal Hyperplasia N/A, Breast Cancer	Under Development	1.80
112	Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)	Charles Wood	BY-SA	Increase, Dopaminergic activity	Increase, Endometrial adenocarcinomas		1.29
498	Increased LCN2/iron complex leading to neurological disorders	Young Jun Kim	Open for adoption	Increased LCN2/iron complex binds to SLC22A17 receptor in neuron	Neurological disorder
81	Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure	Carlie LaLone	BY-SA		Decrease, Number of worker bees Death/Failure, Colony		1.29
294	Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer	Jessica Helm	BY-SA	Increase in reactive oxygen and nitrogen species (RONS)	Increase, DNA damage Increase, Mutations Increased, Ductal Hyperplasia N/A, Breast Cancer	Under Development	1.80
488	Increased reactive oxygen species production leading to decreased cognitive function	Eliska Kuchovska	BY-SA	Increase, Reactive Oxygen Species production	Cognitive Function, Decreased
431	Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)	Qi Wang	BY-SA	Increase, TNF	Gestational diabetes mellitus
298	Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer	Shihori Tanabe	BY-SA	Increases in cellular reactive oxygen species Chronic reactive oxygen species	Treatment-resistant gastric cancer	EAGMST Under Review	1.58
349	Inhibition of 11β-hydroxylase leading to decresed population trajectory	Young Jun Kim	BY-SA	11β-hydroxylase inhibition	Decrease, Population growth rate	Under Development	1.93
348	Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory	Young Jun Kim	BY-SA	Inhibition of 11β-HSD	Decrease, Population growth rate	Under Development	1.93
288	Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)	Bérénice COLLET	BY-SA	Inhibition, Cytochrome P450 enzyme (CYP17A1) activity	Malformation, cryptorchidism - maldescended testis
289	Inhibition of 5α-reductase leading to impaired fecundity in female fish	Young Jun Kim	BY-SA	Inhibition, 5α-reductase	Decrease, Population growth rate	Under Development	1.81
120	Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)	Charles Wood	BY-SA	Inhibition, 5α-reductase activity	Increase, Leydig cell tumors		1.29
398	Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary	Terje Svingen	BY-SA	Inhibition of ALDH1A (RALDH)	impaired, Fertility	Under Development	1.97
383	Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis	Young Jun Kim	BY-SA	Induced dysregulation of ACE2	N/A, Liver fibrosis	Under Development	1.96
154	Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response	Takumi Ohishi	BY-SA	Inhibition, Calcineurin Activity	Impairment, T-cell dependent antibody response	WPHA/WNT Endorsed	1.38
276	Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome	Marvin Martens	BY-SA	Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)	Chemical induced Fanconi syndrome
218	Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity	Florence Pagé-Larivière	BY-SA	CYP7B activity, inhibition	Decrease, Population growth rate
219	Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior	Florence Pagé-Larivière	BY-SA	CYP7B activity, inhibition	Decrease, Population growth rate
301	Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis	Young Jun Kim	BY-SA	Inhibition of cystathionine beta-synthase	Impaired,anterior-posterior axis development
213	Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)	Lyle Burgoon	Open for adoption	Inhibition, Fatty Acid Beta Oxidation	N/A, Steatohepatisis
399	Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)	Vid Modic	BY-SA	Inhibition of Fyna	Increased Mortality Decrease, Population growth rate
32	Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors	Michelle Embry	BY-SA
110	Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)	Charles Wood	BY-SA	Inhibition, Na+/I- symporter (NIS)	Increase, Adenomas/carcinomas (follicular cell)		1.29
315	Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response	Yasuhiro Yoshida	BY-SA	Inhibition of JAK3	Impairment of T-cell dependent antibody response	Under Development	1.74
242	Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity	Stefan Scholz	Open for adoption	Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts	Growth, reduction Decreased, survival
256	Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity	Angela Mally	BY-SA	Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)	Occurrence, Kidney toxicity	Under Development	1.43
437	Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity	Baki Sadi	BY-SA	Inhibition, Mitochondrial Electron Transport Chain Complexes	Occurrence, Kidney toxicity	Under Development	1.99
285	Inhibition of N-linked glycosylation leads to liver injury	Marvin Martens	BY-SA	Inhibition of N-linked glycosylation	Liver Injury
54	Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment	Anna Price	BY-SA	Inhibition, Na+/I- symporter (NIS)	Impairment, Learning and memory	WPHA/WNT Endorsed	1.28
108	Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)	Charles Wood	BY-SA	Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme	Increase, hepatocellular adenomas and carcinomas		1.29
436	Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries	Gina Mennen	BY-SA	Inhibition of ALDH1A (RALDH)	transposition of the great arteries
297	Inhibition of retinaldehyde dehydrogenase leads to population decline	Young Jun Kim	BY-SA	Retinaldehyde dehydrogenase inhibition	Decrease, Population growth rate	Under Development	1.77
3	Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits	Andrea Terron	BY-SA	Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)	Parkinsonian motor deficits	WPHA/WNT Endorsed	1.33
119	Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)	Charles Wood	BY-SA	Thyroperoxidase, Inhibition	Increase, Adenomas/carcinomas (follicular cell)		1.29
271	Inhibition of thyroid peroxidase leading to impaired fertility in fish	June-Woo Park	BY-SA	Thyroperoxidase, Inhibition	Reduction, Cumulative fecundity and spawning	Under Development	1.59
42	Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Kevin Crofton	BY-SA	Thyroperoxidase, Inhibition	Cognitive Function, Decreased	WPHA/WNT Endorsed	1.10
292	Inhibition of tyrosinase leads to decreased population in fish	Young Jun Kim	BY-SA	Inhibition of tyrosinase	Decrease, Population growth rate	Under Development	1.78
489	Inhibition of voltage-gated sodium channels leading to decreased cognition	Eliska Kuchovska	BY-SA	Binding to voltage-gated sodium channel	Cognitive Function, Decreased
451	Interaction with lung resident cell membrane components leads to lung cancer	Penny Nymark	BY-SA	Substance interaction with the lung resident cell membrane components	Lung cancer
152	Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity	Kristie Sullivan	BY-SA	Binding, Transthyretin in serum	Cognitive Function, Decreased	Under Development	1.41
136	Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors	Justin Teeguarden	BY-SA	Decrease, Intracellular pH	Increase, Site of Contact Nasal Tumors	EAGMST Under Review	2.7
188	Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	Inhibition, Iodotyrosine deiodinase (IYD)	Altered, Amphibian metamorphosis		1.29
444	Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability	Deborah Oughton	BY-SA	Deposition of Energy Increase in reactive oxygen and nitrogen species (RONS) Increase, DNA damage	Decrease, Population growth rate
441	Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation	Olivier ARMANT	BY-SA	Deposition of Energy	Increase risk, microcephaly
160	Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality	Knut Erik Tollefsen	BY-SA	Activation, ionotropic GABA Receptor chloride channel	Increased Mortality
208	Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure	Jinhee Choi	All rights reserved		Reproductive failure
201	Juvenile hormone receptor agonism leading to male offspring induction associated population decline	Knut Erik Tollefsen	BY-SA	Activation, Juvenile hormone receptor	Increased, Male offspring Decline, Population Alteration, Food-web structures
128	Kidney dysfunction by decreased thyroid hormone	Jung-Hwa Oh	BY-SA	Thyroid hormone synthesis, Decreased	Occurrence, Kidney toxicity	Under Development	1.40
447	Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways	Yann GUEGUEN	BY-SA		Increased, Kidney Failure
33	Kidney toxicity induced by activation of 5HT2C	Kevin Crofton	Open for adoption	Activation, 5HT2c	Increased, Kidney Failure
467	Knickkopf leading to mortality	Donggon Yoo	BY-SA	Decrease, 20-hydroxyecdysone
261	L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility	Luigi Margiotta-Casaluci	All rights reserved	Blockade, L-Type Calcium Channels	Heart failure	Under Development	1.45
283	L-type calcium channel blockade leading to hypotension	Luigi Margiotta-Casaluci	All rights reserved			Under Development	1.45
262	L-type calcium channel blockade leading to the disruption of cardiac electrophysiology	Luigi Margiotta-Casaluci	All rights reserved			Under Development	1.45
241	Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis	Marvin Martens	BY-SA	Activation, Latent Transforming Growth Factor Beta 1	Pulmonary fibrosis
302	Lung surfactant function inhibition leading to decreased lung function	Jorid Birkelund Sørli	BY-SA	Inhibition of lung surfactant function	Decrease, Lung function	Under Development	1.87
309	Luteinizing hormone receptor antagonism leading to reproductive dysfunction	Young Jun Kim	BY-SA	Antagonism,LH receptor	Decline, Population trajectory
34	LXR activation leading to hepatic steatosis	Marina Goumenou	BY-SA	Activation, LXR peroxisome proliferator activated receptor promoter demethylation	N/A, Liver Steatosis
222	Mental stress to agitation	Lyle Burgoon	Open for adoption	Increased, glucocorticoid receptor activity	Increased, agitation
221	Mental stress to depression	Lyle Burgoon	Open for adoption	Increased, glucocorticoid receptor activity	Increased, depression
404	Metabolic Syndrome leading to Toll Like Receptor dysregulation	Gillina Bezemer	BY-SA
279	Microtubule interacting drugs lead to peripheral neuropathy	Marvin Martens	BY-SA	Binding of microtubule stabilizing agents (MSA) to microtubules	Sensory axonal peripheral neuropathy
290	Mitochondrial ATP synthase antagonism leading to growth inhibition (1)	You Song	BY-SA	Increase, Mitochondrial ATP synthase antagonism	Decrease, Growth
291	Mitochondrial ATP synthase antagonism leading to growth inhibition (2)	You Song	BY-SA	Increase, Mitochondrial ATP synthase antagonism	Decrease, Growth
286	Mitochondrial complex III antagonism leading to growth inhibition (1)	You Song	BY-SA	Increase, Mitochondrial complex III antagonism	Decrease, Growth
287	Mitochondrial complex III antagonism leading to growth inhibition (2)	You Song	BY-SA	Increase, Mitochondrial complex III antagonism	Decrease, Growth
273	Mitochondrial complex inhibition leading to liver injury	Wanda van der Stel	BY-SA	Increase, Mitochondrial complex III antagonism Mitochondrial Complex IV inhibition Mitochondrial Complex V inhibition Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) Inhibition, NADH-ubiquinone oxidoreductase (complex I) Binding of inhibitor to mitochondrial complex III Binding of inhibitor to mitochondrial complex IV Binding of inhibitor to mitochondrial complex V	Necrotic Tissue Liver Injury
480	Mitochondrial complexes inhibition leading to heart failure via decreased ATP production	Alexandra Schaffert	BY-SA	Inhibition, Mitochondrial Electron Transport Chain Complexes	Heart failure Increase, Mortality	Under Development	1.102
479	Mitochondrial complexes inhibition leading to heart failure via increased myocardial oxidative stress	Sivakumar Murugadoss	BY-SA	Inhibition, Mitochondrial Electron Transport Chain Complexes	Heart failure Increase, Mortality	Under Development	1.102
373	Mitochondrial dysfunction to metabolic diseases	Chander K. Negi	BY-SA
66	Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis	Gary Klinefelter	BY-SA	Decreased testosterone by the fetal Leydig cells, Increased corticosterone Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists	Decreased sperm quantity / quality in the adult, Decreased fertility		1.29
68	Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome	Gary Klinefelter	BY-SA	Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome	Decreased sperm quantity / quality in the adult, Decreased fertility		1.29
69	Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell	Gary Klinefelter	BY-SA	Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol Decreased Cholesterol, Decreased Uptake of Lipoproteins Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane	Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis		1.29
67	Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis	Gary Klinefelter	BY-SA	Decreased testosterone by the fetal Leydig cells, Increased estradiol Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists	Decreased sperm quantity / quality in the adult, Decreased fertility		1.29
71	Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation	Gary Klinefelter	BY-SA	Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid	Decreased sperm quantity or quality in the adult, Decreased fertility		1.29
74	Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis	Gary Klinefelter	BY-SA	Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis	Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis		1.29
70	Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell	Gary Klinefelter	BY-SA	Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell	Decreased sperm quantity or quality in the adult, Decreased fertility		1.29
215	Molecular events lead to epilepsy	Lyle Burgoon	Open for adoption		Increase, seizure Increased, hippocampal hyperdepolarization Increased, epilepsy
234	Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition	Timothy Allen	BY-SA	Mu Opioid Receptor Agonism	Analgesia
233	Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening	Timothy Allen	BY-SA	Mu Opioid Receptor Agonism	Analgesia
516	Na+ /K+ -ATPase inhibition leading to hypertension	Michelle Angrish	All rights reserved	Decreased Na/K ATPase activity	Hypertension
207	NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans	Jinhee Choi	All rights reserved	Activation, NADPH Oxidase	Reproductive failure
35	Narcosis leading to respiratory failure	Dries Knapen	BY-SA	Accumulation, Biological membranes		Under Development	1.2
214	Network of SSRIs (selective serotonin reuptake inhibitors)	Lyle Burgoon	Open for adoption		Increased, seizure Increased, agitation Increased, depression Increase, hypertension
232	NFE2/Nrf2 repression to steatosis	Lyle Burgoon	Open for adoption	NFE2/Nrf2 repression	Increased, steatosis
61	NFE2L2/FXR activation leading to hepatic steatosis	Michelle Angrish	BY-SA	Activation, NRF2 Activation, NR1H4	Increased, Liver Steatosis		1.29
77	Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1	Carlie LaLone	BY-SA	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony		1.29
87	Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure	Carlie LaLone	BY-SA	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony		1.29
88	Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste	Carlie LaLone	BY-SA	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony		1.29
78	Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1	Carlie LaLone	BY-SA	Activation, Nicotinic acetylcholine receptor	impaired, Larval development Death/Failure, Colony		1.29
90	Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2	Carlie LaLone	BY-SA	Activation, Nicotinic acetylcholine receptor	impaired, Larval development Death/Failure, Colony		1.29
80	Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure	Carlie LaLone	BY-SA	Activation, Nicotinic acetylcholine receptor	Decrease, Number of worker bees impaired, Hive thermoregulation Death/Failure, Colony		1.29
79	Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure	Carlie LaLone	BY-SA	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony		1.29
178	Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure	Carlie LaLone	BY-SA	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony		1.29
89	Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure	Carlie LaLone	BY-SA	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony		1.29
184	Nosema infection causes abnormal role change that leads to colony loss/failure	Carlie LaLone	BY-SA		Death/Failure, Colony		1.29
183	Nosema infection increases energetic demands leading to colony loss/failure	Carlie LaLone	BY-SA		Death/Failure, Colony		1.29
60	NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis	Michelle Angrish	BY-SA	Activation, PXR/SXR	Increased, Liver Steatosis		1.29
58	NR1I3 (CAR) suppression leading to hepatic steatosis	Michelle Angrish	BY-SA	Suppression, Constitutive androstane receptor, NR1l3 Inhibition, PPAR alpha Activation, LXR peroxisome proliferator activated receptor promoter demethylation	Increased, Liver Steatosis		1.29
509	Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction	Yanhong Wei	All rights reserved	NFE2/Nrf2 repression	Increase, Vascular disrupting effects
508	Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway	Yanhong Wei	All rights reserved	NFE2/Nrf2 repression	Increase, Vascular disrupting effects
507	Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway	Yanhong Wei	All rights reserved	NFE2/Nrf2 repression	Increase, Vascular disrupting effects
227	NSAID induced PTGS1 inactivation to gastric ulcer	Lyle Burgoon	Open for adoption	Reduced, PTGS1 function	Activated, gastric ulcer formation
228	NSAID induced PTGS2 inactivation to gastric ulcer	Lyle Burgoon	Open for adoption	Reduced, PTGS2 function	Activated, gastric ulcer formation
138	Organic anion transporter (OAT1) inhibition leading to renal failure and mortality	Kellie Fay	BY-SA	Inhibition, organic anion transporter 1 (OAT1)	Increased Mortality Decrease, Population growth rate		1.29
405	Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function	SAROJ AMAR	BY-SA	Acetylcholinesterase (AchE) Inhibition	Cognitive Function, Decreased
413	Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure	Zarin Hossain	BY-SA	Oxidation, Glutathione (To be considered with MIE)	Increased Mortality
31	Oxidation of iron in hemoglobin leading to hematotoxicity	Mitchell S. Wilbanks	Open for adoption	N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)	N/A, Cyanosis occurs	Under Development	1.16
296	Oxidative DNA damage leading to chromosomal aberrations and mutations	Carole Yauk	BY-SA	Increase, Oxidative damage to DNA	Increase, Mutations Increase, Chromosomal aberrations	WPHA/WNT Endorsed	1.76
411	Oxidative stress Leading to Decreased Lung Function	Karsta Luettich	BY-SA	Oxidative Stress	Decrease, Lung function
424	Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction	Karsta Luettich	BY-SA	Oxidative Stress	Decrease, Lung function
425	Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1	Karsta Luettich	BY-SA	Oxidative Stress	Decrease, Lung function
239	Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling	Annie Jarabek	BY-SA
192	Pendrin inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	Inhibition, Pendrin	Altered, Amphibian metamorphosis		1.29
149	Peptide Oxidation Leading to Hypertension	Frazer Lowe	BY-SA	Peptide Oxidation	Hypertension	Under Development	1.50
11	Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol	Jun Kanno	BY-SA	Activation, PXR/SXR		Under Development	2.5
36	Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis	Michelle Angrish	BY-SA	Decreased, PPAR-alpha activation Decreased, PPAR-beta activation Decreased, PPAR-gamma activation	Increased, Liver Steatosis		1.29
206	Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis	Jinhee Choi	All rights reserved	Inactivation of PPARγ	Lung fibrosis	Under Development	1.54
209	Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP	Jinhee Choi	All rights reserved		Hepatotoxicity
130	Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity	Jung-Hwa Oh	BY-SA	Inhibition, Phospholipase A	Formation, Liver fibrosis	Under Development	1.39
371	Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone	You Song	BY-SA
369	Photosystem II antagonism leading to growth inhibition via oxidative damage	You Song	BY-SA
370	Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis	You Song	BY-SA
514	PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV	Hui Li	All rights reserved
446	PM-related Adverse outcome pathway frameworks on various systems	Tianyu Li	BY-SA
454	PM2.5-related AOP frameworks on liver diseases	Zhou Du	BY-SA
166	PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse	Charles Wood	BY-SA		Increased, Pancreatic acinar tumors		1.29
323	PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone	Jennifer Olker	BY-SA	Activation, PPARα	Decreased, Viable Offspring Decrease, Population growth rate
421	PPARG activation leading to intrahepatic cholestasis	Yuan Jin	All rights reserved
163	PPARgamma activation leading to sarcomas in rats, mice, and hamsters	Charles Wood	BY-SA	Activation of specific nuclear receptors, PPAR-gamma activation			1.29
18	PPARα activation in utero leading to impaired fertility in males	Elise Grignard	BY-SA	Activation, PPARα	impaired, Fertility Malformation, Male reproductive tract	EAGMST Under Review	1.21
37	PPARα activation leading to hepatocellular adenomas and carcinomas in rodents	Chris Corton	BY-SA	Activation, PPARα	Increase, hepatocellular adenomas and carcinomas	Under Development	1.17
51	PPARα activation leading to impaired fertility in adult male rodents	Elise Grignard	BY-SA	Activation, PPARα	impaired, Fertility	Under Development	1.21
517	Pregnane X Receptor (PXR) activation leads to liver steatosis	John Frisch	BY-SA	Activation, Pregnane-X receptor, NR1l2	N/A, Liver Steatosis
230	presynaptic neuron 1 activation to epilepsy	Lyle Burgoon	Open for adoption	Activated, presynaptic neuron 1	Increased, epilepsy
231	presynaptic neuron 2 repression to epilepsy	Lyle Burgoon	Open for adoption	Reduced, presynaptic neuron 2 activity	Increased, epilepsy
122	Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation	Dalma Martinovic-Weigelt	BY-SA	Inhibition, Prolyl hydroxylases	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate		1.29
38	Protein Alkylation leading to Liver Fibrosis	Brigitte Landesmann	BY-SA	Alkylation, Protein	N/A, Liver fibrosis	WPHA/WNT Endorsed	1.14
185	Queen egg-laying decrease leads to colony loss/failure	Carlie LaLone	BY-SA		Death/Failure, Colony		1.29
513	Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway	John Frisch	BY-SA	Increased, Reactive oxygen species	Increase, Cancer
505	Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway	John Frisch	BY-SA	Increased, Reactive oxygen species	Increase, Cancer
453	Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population	ruiyang Ding	BY-SA
438	reactive oxygen species generation leading to increased cardiovascular morbidity and mortality	Yu Yang	All rights reserved
469	Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population	ruiyang Ding	BY-SA
257	Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity	Angela Mally	BY-SA	Binding of substrate, endocytic receptor	Occurrence, Kidney toxicity	Under Development	1.43
512	Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level	Ana-Andreea Cioca	All rights reserved
321	Reduced environmental pH leading to thinner shells in Mytilus edulis	James Ducker	BY-SA
245	Reduction in photophosphorylation leading to growth inhibition in aquatic plants	Knut Erik Tollefsen	BY-SA	Increase, Uncoupling of photophosphorylation	Decrease, Growth
258	Renal protein alkylation leading to kidney toxicity	Angela Mally	BY-SA	Alkylation, Protein	Occurrence, Kidney toxicity	Under Development	1.43
448	ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality	ruiyang Ding	BY-SA
342	S-adenosylmethionine depletion leading to population decline (1)	You Song	BY-SA	Inhibition, Chitin synthase 1	Increase, Mortality
343	S-adenosylmethionine depletion leading to population decline (2)	You Song	BY-SA	Increase, Sulfonylurea receptor binding	Increase, Mortality
406	SARS-CoV-2 infection leading to hyperinflammation	Hasmik Yepiskoposyan	All rights reserved	Binding to ACE2	Hyperinflammation
407	SARS-CoV-2 infection leading to pyroptosis	Hasmik Yepiskoposyan	All rights reserved	Binding to ACE2	Pyroptosis
394	SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)	Sandra Coecke	BY-SA	Binding to ACE2	impaired olfactory function (anosmia)	Under Development	1.96
426	SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.	Evangelos-Panagiotis Daskalopoulos	BY-SA	Binding to ACE2	Myocardial Infarction
259	Sensitization induction of the intestinal tract by food proteins	Erwin L Roggen	BY-SA
236	Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition	Timothy Allen	BY-SA	Serotonin 1A Receptor Agonism	Anti-depressant Activity
235	Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening	Timothy Allen	BY-SA	Serotonin 1A Receptor Agonism	Anti-depressant Activity
225	Serotonin transporter activation to agitation	Lyle Burgoon	Open for adoption		Increased, agitation
224	Serotonin transporter activation to depression	Lyle Burgoon	Open for adoption	Increased, serotonin transporter activity	Increased, depression
223	Serotonin transporter activation to seizure	Lyle Burgoon	Open for adoption	Increased, serotonin transporter activity	Increased, seizure
197	Sodium channel (Nav1.1) inhibition leading to population decline	Kellie Fay	BY-SA	Inhibition, sodium channel			1.29
94	Sodium channel inhibition leading to congenital malformations	Kellie Fay	BY-SA	Inhibition, sodium channel	Increased, amputations		1.29
93	sodium channel inhibition leading to increased predation	Kellie Fay	BY-SA	Inhibition, sodium channel	Increased, predation		1.29
91	Sodium channel inhibition leading to reduced survival	Kellie Fay	BY-SA	Inhibition, sodium channel	Reduced, feeding 1 Increased, predation Reduced, survival		1.29
134	Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Mary Gilbert	BY-SA	Inhibition, Na+/I- symporter (NIS)	Cognitive Function, Decreased		1.29
176	Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	Inhibition, Na+/I- symporter (NIS)	Altered, Amphibian metamorphosis		1.29
226	SSRI (Selective serotonin reuptake inhibitor) to hypertension	Lyle Burgoon	Open for adoption	Decreased, serotonin transporter activity	Increase, hypertension
313	Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease	Hiroyuki Komatsu	BY-SA	Stimulation, TLR7/8	Psoriatic skin disease	Under Development	1.75
237	Substance interaction with lung resident cell membrane components leading to atherosclerosis	Ulla Vogel	BY-SA	Substance interaction with the lung resident cell membrane components	Atherosclerosis	Under Development	1.55
173	Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis	Sabina Halappanavar	All rights reserved	Substance interaction with the lung resident cell membrane components	Pulmonary fibrosis	WPHA/WNT Endorsed	1.32
474	Succinate dehydrogenase inactivation leading to cancer	Sylvie Bortoli	BY-SA			Under Development	1.106
457	Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine	Simon Thomas	BY-SA	Succinate dehydrogenase, inhibited	Insulin resistance, increased
361	Sulfonylureareceptor binding leading to mortality	Simon Schmid	All rights reserved	Increase, Sulfonylurea receptor binding	Increase, Mortality	Under Development	1.94
504	SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level	Ana-Andreea Cioca	All rights reserved	Inhibition of Sulfotransferase E1 (SULT1E1)
85	Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure	Carlie LaLone	BY-SA		Decrease, Number of worker bees Death/Failure, Colony		1.29
84	Suppression of immune system contributes to impaired development and leads to colony loss/failure	Carlie LaLone	BY-SA		Decrease, Number of worker bees impaired, Hive thermoregulation Death/Failure, Colony		1.29
41	Sustained AhR Activation leading to Rodent Liver Tumours	Rick Becker	BY-SA	Activation, Long term AHR receptor driven direct and indirect gene expression changes	Formation, Hepatocellular and Bile duct tumors	EAGMST Under Review	1.7
304	TBX1 inhibition leading to congenital cardiac conotruncal anomalies	Jinsoo Lee	All rights reserved	Inhibition, TBX1	Anomalies, Congenital cardiac conotruncal
375	test AOP	Kevin Crofton	BY-SA
511	The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects	Yanhong Wei	All rights reserved	Increase, Reactive Oxygen Species production	Increase, Vascular disrupting effects
463	The AOP framwork on silica nanopariticles induced hepatoxicity	Tianyu Li	BY-SA
324	Thermal stress leading to population decline (1)	You Song	BY-SA	N/A, Mitochondrial dysfunction 1	Decrease, Fecundity Decrease, Population growth rate
325	Thermal stress leading to population decline (2)	You Song	BY-SA	N/A, Mitochondrial dysfunction 1	Decrease, Fecundity Decrease, Population growth rate
326	Thermal stress leading to population decline (3)	You Song	BY-SA	N/A, Mitochondrial dysfunction 1	Decrease, Fecundity Decrease, Population growth rate
485	Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition	Eliska Kuchovska	BY-SA	Antagonism, Thyroid Receptor	Cognitive Function, Decreased
402	Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain	Katherine (Katie) O'Shaughnessy	BY-SA	Thyroperoxidase, Inhibition	Periventricular heterotopia formation Increase, seizure
300	Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Kevin Crofton	BY-SA	Antagonism, Thyroid Receptor	Cognitive Function, Decreased	Under Development	1.84
175	Thyroperoxidase inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	Thyroperoxidase, Inhibition	Altered, Amphibian metamorphosis		1.29
365	Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning	Lucia Vergauwen	All rights reserved	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate	Under Development	1.35
363	Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure	Lucia Vergauwen	BY-SA	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate	EAGMST Under Review	1.35
364	Thyroperoxidase inhibition leading to altered visual function via decreased eye size	Lucia Vergauwen	All rights reserved	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate	Under Development	1.35
159	Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation	Dries Knapen	BY-SA	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate	WPHA/WNT Endorsed	1.35
347	Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis	Seokjoo Yoon	BY-SA	Toll-like receptor 4 activation Inactivation of PPARγ	Pulmonary fibrosis
316	Trypsin inhibition leading to pancreatic acinar cell tumors	Shigeru Hisada	BY-SA	Trypsin inhibition	Pancreatic acinar cell tumors	Under Development	1.60
189	Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	Inhibition, Deiodinase 1	Altered, Amphibian metamorphosis		1.29
190	Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	Inhibition, Deiodinase 2	Altered, Amphibian metamorphosis		1.29
191	Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	Inhibition, Deiodinase 3	Altered, Amphibian metamorphosis		1.29
263	Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation	You Song	BY-SA	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	WPHA/WNT Endorsed	1.92
264	Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death	You Song	BY-SA	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	Under Development	1.92
266	Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity	You Song	BY-SA	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	Under Development	1.92
267	Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion	You Song	BY-SA	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	Under Development	1.92
265	Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium	You Song	BY-SA	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	Under Development	1.92
268	Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling	You Song	BY-SA	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	Under Development	1.92
487	Unknown MIE altering cholesterol metabolism leading to decreased cognition	Eliska Kuchovska	BY-SA	Unknown, MIE	Cognitive Function, Decreased
186	unknown MIE leading to renal failure and mortality	Kellie Fay	BY-SA	Unknown, MIE	Increased Mortality		1.29
123	Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription	Dalma Martinovic-Weigelt	BY-SA	modulation, Unknown	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate		1.29
8	Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Katie Paul Friedman	Open for adoption	Activation, Pregnane-X receptor, NR1l2	Loss, Cochlear function	Under Development	1.9
121	Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)	Charles Wood	BY-SA	Increase, Urinary bladder calculi	Increase, Adenomas/carcinomas (urothelial)		1.29
471	Various neuronal effects induced by elavl3, sox10, and mbp	Donggon Yoo	BY-SA	Increase, CNS Neural cell death	impaired, Learning and memory Encephalitis Parkinsonian motor deficits Increase, seizure Increased, epilepsy Increase, Mortality Inhibition, Feeding
180	Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure	Carlie LaLone	BY-SA		Death/Failure, Colony		1.29
179	Varroa mite infestation increases virus levels leading to colony loss/failure	Carlie LaLone	BY-SA		Death/Failure, Colony		1.29
385	Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation	Julija Filipovska	BY-SA	Binding to ACE2
196	Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation	Jeanelle Martinez	BY-SA	TRPA1 activation, TRPA1 Receptor	Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea Irritation of nasal mucosa inducing sneeze reflex Increased Respiratory irritability and Chronic Cough,
182	Weather event contributes abnormal foraging leading to colony loss/failure	Carlie LaLone	BY-SA		Death/Failure, Colony		1.29
181	Weather event contributes to colony loss/failure	Carlie LaLone	BY-SA		Death/Failure, Colony		1.29
73	Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity	Tammy Stoker	BY-SA	Inhibition, Inhibition of Dopamine-beta-hydroxylase	Decreased, Decreased fecundity		1.29
280	α-diketone-induced bronchiolitis obliterans	Marvin Martens	BY-SA	Interaction of α-diketones with arginine residues	Bronchiolitis obliterans