AOPs

ID Title Point of Contact License MIE AO OECD Status OECD Project
443 DNA damage and mutations leading to Metastatic Breast Cancer Usha Adiga BY-SA
  • Increased, DNA damage and mutation
  • metastatic breast cancer
Under Development 1.103
450 Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality SAROJ AMAR BY-SA
  • Acetylcholinesterase (AchE) Inhibition
  • Sensory axonal peripheral neuropathy
  • Increased Mortality
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron BY-SA
  • Binding to (interferes with) topoisomerase II enzyme
  • Infant leukaemia
WPHA/WNT Endorsed 1.53
389 Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA
  • Increase, Oxygen-evolving complex damage
  • Decrease, Reproduction
  • Decrease, Population growth rate
423 Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Fei Li BY-SA
  • Activation, PARP1
  • ROS formation
  • Apoptotic cell death
98 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh BY-SA
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increased, predation
1.29
97 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Kellie Fay BY-SA
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increase, predation
  • Decrease, Population growth rate
1.29
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay BY-SA
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increased, Population
1.29
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Kellie Fay BY-SA
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Decreased, Reproductive Success
  • Decrease, Population growth rate
1.29
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Kellie Fay BY-SA
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increased, Reproductive Success
  • Increased, Population
1.29
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA
  • Inhibition, 5α-reductase
  • anogenital distance (AGD), decreased
Under Development 1.90
429 A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants Erwin L Roggen BY-SA
  • Memory Loss
82 Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Carlie LaLone BY-SA
  • impaired, Larval development
  • Death/Failure, Colony
1.29
427 ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. Evangelos-Panagiotis Daskalopoulos BY-SA
  • Binding to ACE2
  • Heart failure
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve BY-SA
  • Acetylcholinesterase (AchE) Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
Under Development 1.3
312 Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan BY-SA
  • Acetylcholinesterase (AchE) Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
281 Acetylcholinesterase Inhibition Leading to Neurodegeneration Karen Watanabe BY-SA
  • Acetylcholinesterase (AchE) Inhibition
  • N/A, Neurodegeneration
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi All rights reserved
  • Reproductive failure
499 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release Travis Karschnik All rights reserved
  • Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
  • Impairment, Learning and memory
500 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis Travis Karschnik All rights reserved
  • Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
  • Impairment, Learning and memory
462 Activation of reactive oxygen species leading the atherosclerosis Hiromi Ohara BY-SA
439 Activation of the AhR leading to metastatic breast cancer Louise Benoit BY-SA
  • Activation, AhR
  • metastatic breast cancer
Under Development 1.105
503 Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation Barbara Viviani BY-SA
  • Activation, estrogen receptor alpha
  • Uterine adenocarcinoma (endometrioid adenocarcinoma Type I)
Under Review 1.100
538 Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways Yanhong Wei All rights reserved
  • Increase, Vascular disrupting effects
452 Adverse outcome pathway of PM-induced respiratory toxicity li qing BY-SA
  • Non-coding RNA expression profile alteration
  • Chronic obstructive pulmonary disease
282 Adverse outcome pathway on photochemical toxicity initiated by light exposure Satomi Onoue BY-SA
  • ROS generation from photoactivated chemicals
  • Inflamatory events in light-exposed tissues
Under Review 1.49
476 Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity Yue Zhang All rights reserved
  • Increased, Reactive oxygen species
  • Disruption, Estrogen receptor
  • Antagonism, Androgen receptor
  • Decreased sperm quantity or quality in the adult, Decreased fertility
  • anogenital distance (AGD), decreased
  • Malformation, cryptorchidism - maldescended testis
  • Decrease, Reproduction
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon BY-SA
  • Formation, Pro-mutagenic DNA Adducts
  • Tumorigenesis, Hepatocellular carcinoma
Under Review 1.8
458 AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Open for adoption
  • Activation, AhR
  • Cognitive Function, Decreased
459 AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Open for adoption
  • Activation, AhR
  • Cognitive Function, Decreased
57 AhR activation leading to hepatic steatosis Michelle Angrish BY-SA
  • Activation, AhR
  • Increased, Liver Steatosis
1.29
494 AhR activation leading to liver fibrosis Xavier COUMOUL All rights reserved
  • Activation, AhR
  • N/A, Liver fibrosis
151 AhR activation leading to preeclampsia Sabrina Tait All rights reserved
  • Activation, AhR
  • increase, Preeclampsia
Under Development 1.42
62 AKT2 activation leading to hepatic steatosis Michelle Angrish BY-SA
  • systemic inflammation leading to hepatic steatosis
  • Increased, Liver Steatosis
1.29
465 Alcohol dehydrogenase leading to reproductive dysfunction Donggon Yoo BY-SA
  • Increase, Alcohol dehydrogenase
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk BY-SA
  • Alkylation, DNA
  • Increase, Heritable mutations in offspring
WPHA/WNT Endorsed 1.11
139 Alkylation of DNA leading to cancer 1 Carole Yauk Open for adoption
  • Alkylation, DNA
  • Increase, Cancer
322 Alkylation of DNA leading to reduced sperm count Carole Yauk BY-SA
  • Alkylation, DNA
  • Reduce, Sperm count
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Undefined BY-SA
  • Inhibition, Antgonism of NE receptor
  • Decreased, Decreased fecundity
1.29
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood BY-SA
  • Increased, Binding of chemicals to 2u (serum)
  • Increase, Adenomas/carcinomas (renal tubular)
1.29
104 Altered ion channel activity leading impaired heart function Undefined BY-SA
  • impaired, ion channels
  • Increased Mortality
1.29
541 An adverse outcome pathway linking ROS generation to vascular calcification Ruiyang Ding All rights reserved
515 An overview of adverse outcome pathway linked between PM2.5 exposure and congenital heart defects Liang Chen All rights reserved
345 Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen BY-SA
  • Antagonism, Androgen receptor
  • irregularities, ovarian cycle
  • impaired, Fertility
Under Development 1.109
477 Androgen receptor (AR) antagonism leading to hypospadias in male offspring Terje Svingen BY-SA
  • Antagonism, Androgen receptor
  • Hypospadias, increased
344 Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen BY-SA
  • Antagonism, Androgen receptor
  • Nipple retention (NR), increased
Under Development 1.108
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA
  • Antagonism, Androgen receptor
  • anogenital distance (AGD), decreased
Under Development 1.90
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Open for adoption
  • Activation, Androgen receptor
  • Increase, hepatocellular adenomas and carcinomas
Under Development 1.26
495 Androgen receptor activation leading to prostate cancer Jianxiang Li All rights reserved
  • Activation, Androgen receptor
  • Prostate cancer
376 Androgen receptor agonism leading to male-biased sex ratio Dan Villeneuve BY-SA
  • Agonism, Androgen receptor
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.12
496 Androgen receptor agonism leading to reproduction dysfunction (in zebrafish) Hongling Liu BY-SA
  • Agonism, Androgen receptor
  • Increased, gene expression of AR
  • Decreased, Population trajectory
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve BY-SA
  • Agonism, Androgen receptor
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.12
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel Open for adoption
  • N/A, Androgen receptor, Antagonism
  • N/A, Impairment of reproductive capacity
372 Androgen receptor antagonism leading to testicular cancer Chander K. Negi BY-SA
  • Antagonism, Androgen receptor
  • Testicular Cancer
382 Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Young Jun Kim BY-SA
  • Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
  • Lung fibrosis
Under Development 1.96
460 Antagonism of Smoothened receptor leading to orofacial clefting Jacob Reynolds All rights reserved
  • Antagonism, Smoothened receptor
  • Orofacial clefting
Under Development 1.101
6 Antagonist binding to PPARα leading to body-weight loss Kurt A. Gust BY-SA
  • Binding of antagonist, PPAR alpha
  • Decreased, Body Weight
WPHA/WNT Endorsed 2.3
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Charles Wood BY-SA
  • Increased, Adenomas/carcinomas (mammary)
1.29
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Undefined BY-SA
  • Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
  • Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
  • Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
  • Impaired recruitment , Population trajectory
Under Development 1.31
165 Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Charles Wood BY-SA
  • Promotion, ovarian adenomas
  • Promotion, ovarian granular cell tumors
1.29
393 AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation Fei Li BY-SA
  • Increased, Hepatic thyroid hormone uptake/transport
335 AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza BY-SA
  • Mitochondrial dysfunction
  • Urothelial Tumor
205 AOP from chemical insult to cell death Mathieu Vinken BY-SA
  • Decompartmentalization
  • Direct mitochondrial inhibition
  • narcosis
  • Apoptosis
  • Necrosis
481 AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. Hailin Xu BY-SA
  • Increase, Reactive oxygen species
  • Increased incidence of respiratory disease
  • Dysfunction of respiratory system
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard BY-SA
  • reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
  • impaired, Fertility
  • irregularities, ovarian cycle
Under Review 1.21
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Undefined BY-SA
  • Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
  • Decreased fertility, Reduced number of oocytes ovulated
1.29
25 Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve BY-SA
  • Inhibition, Aromatase
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.12
346 Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez BY-SA
  • Inhibition, Aromatase
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.12
456 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity Prarthana Shankar BY-SA
  • Activation, AhR
  • Increase, Early Life Stage Mortality
Under Review
455 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development Prarthana Shankar BY-SA
  • Activation, AhR
  • Increase, Early Life Stage Mortality
  • Facial cartilage structures are reduced in size and morphologically distorted
Under Review
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker BY-SA
  • Activation, AhR
WPHA/WNT Endorsed 1.27
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat BY-SA
  • Activation, AhR
  • Increase, Early Life Stage Mortality
WPHA/WNT Endorsed 1.7
418 Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway Dianke Yu All rights reserved
419 Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Dianke Yu All rights reserved
  • Decrease, Lung function
417 Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway Dianke Yu All rights reserved
  • Activation, AhR
  • Lung cancer
416 Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway Dianke Yu All rights reserved
  • Activation, AhR
  • Lung cancer
420 Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Dianke Yu All rights reserved
  • Activation, AhR
415 Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway Dianke Yu All rights reserved
  • Activation, AhR
  • Lung fibrosis
414 Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway Dianke Yu All rights reserved
  • Activation, AhR
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat BY-SA
  • Activation, AhR
  • Uroporphyria
WPHA/WNT Endorsed 1.7
96 Axonal sodium channel modulation leading to acute mortality Kellie Fay BY-SA
  • modulation, sodium channel
  • Increased Mortality
1.29
164 Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Charles Wood BY-SA
  • Activation, beta-2 adrenergic receptor
  • Promotion, mesovarian leiomyomas
1.29
535 Binding and activation of GPER leading to learning and memory impairments Zedong Ouyang All rights reserved
  • protein-coupled estrogen receptor 1 (GPER) activation
  • Impairment, Learning and memory
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price BY-SA
  • Binding of agonist, Ionotropic glutamate receptors
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.23
475 Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons Shihori Tanabe All rights reserved
  • Binding of agonist, Ionotropic glutamate receptors
  • Impairment, Learning and memory
Under Development 1.107
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich BY-SA
  • Binding, Thiol/seleno-proteins involved in protection against oxidative stress
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.13
284 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois BY-SA
  • Binding, Thiol/seleno-proteins involved in protection against oxidative stress
  • Chronic kidney disease
506 Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation Jessica Resnick All rights reserved
  • Influenza A Virus (IAV) binds sialic acid glycan receptor
  • Influenza A Virus (IAV) shedding and transmission
428 Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis Laure-Alix Clerbaux BY-SA
  • Binding to ACE2
Under Development 1.96
374 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Anna Price All rights reserved
  • Binding to ACE2
  • Encephalitis
Under Development 1.96
395 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) Magda Sachana BY-SA
  • Binding to ACE2
  • Cerebrovascular disease (stroke)
Under Development 1.96
422 Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption Laure-Alix Clerbaux BY-SA
  • Binding to ACE2
Under Development 1.96
468 Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) Laure-Alix Clerbaux BY-SA
  • Binding to ACE2
  • Hyperinflammation
430 Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation Sally Mayasich All rights reserved
  • Binding to ACE2
  • Viral infection and host-to-host transmission, proliferated
Under Development 1.96
320 Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim BY-SA
  • Binding to ACE2
  • Increased Mortality
Under Development 1.96
381 Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Young Jun Kim BY-SA
  • Binding to ACE2
  • dysgeusia
Under Development 1.96
319 Binding to ACE2 leading to lung fibrosis Young Jun Kim BY-SA
  • Induced dysregulation of ACE2
  • Lung fibrosis
Under Development 1.96
379 Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation Shihori Tanabe All rights reserved
  • Binding to ACE2
  • Thrombosis and Disseminated Intravascular Coagulation
Under Development 1.96
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Yasuharu Otsubo BY-SA
  • Binding to estrogen receptor (ER)-α in immune cells
  • Exacerbation of systemic lupus erythematosus (SLE)
Under Development 1.73
486 Binding to the extracellular protein laminin leading to decreased cognitive function Eliska Kuchovska BY-SA
  • Binding, extracellular matrix protein laminin
  • Cognitive Function, Decreased
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Ping Gong BY-SA
  • Binding at picrotoxin site, iGABAR chloride channel
  • Occurrence, Epileptic seizure
WPHA/WNT Endorsed 1.15
442 Binding to voltage gate sodium channels during development leads to cognitive impairment Iris Mangas BY-SA
  • Binding to voltage-gated sodium channel
  • Cognitive Function, Decreased
Under Development 1.91
484 Bisphenol A analogs induce cellular dysfunction in human trophoblast cells in a thyroid hormone receptor-dependent manner: in silico and in vitro analyses Xiaoyun Wu BY-SA
397 Bulky DNA adducts leading to mutations Carole Yauk BY-SA
  • Bulky DNA adducts, increase
  • Increase, Mutations
Under Development 1.11
464 Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits Julia Meerman All rights reserved
  • Activation of metabotropic glutamate receptor
  • Inositol triphosphate receptor activation
  • Overactivation, NMDARs
  • Inhibition GABAA receptor
  • Opening, voltage-gated calcium channels
  • Parkinsonian motor deficits
26 Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon Open for adoption
  • Inhibition, Ca++ ATPase
  • Oxidative Stress
519 Cardiac ion channels blockade leading to arrhythmia associated sudden cardiac death Young Jun Kim Open for adoption
449 Ceramide synthase inhibition leading to neural tube defects Lola Bajard BY-SA
  • Inhibition of Ceramide Synthase
  • Neural tube defects
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti BY-SA
  • Binding, Tubulin
  • Increase, Aneuploid offspring
Under Review 1.11
360 Chitin synthase 1 inhibition leading to mortality Simon Schmid BY-SA
  • Inhibition, Chitin synthase 1
  • Increase, Mortality
WPHA/WNT Endorsed 1.94
358 Chitinase inhibition leading to mortality Simon Schmid All rights reserved
  • Inhibition, Chitinase
  • Increase, Mortality
Under Development 1.94
359 Chitobiase inhibition leading to mortality Simon Schmid All rights reserved
  • Inhibition, Chitobiase
  • Increase, Mortality
Under Development 1.94
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken BY-SA
  • Inhibition, Bile Salt Export Pump (ABCB11)
  • Cholestasis, Pathology
Under Development 1.19
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price BY-SA
  • Binding of antagonist, NMDA receptors
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.22
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet BY-SA
  • Binding of antagonist, NMDA receptors
  • N/A, Neurodegeneration
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.13
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood BY-SA
  • Increase, Cytotoxicity (hepatocytes)
  • Increase, hepatocellular adenomas and carcinomas
1.29
171 Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Charles Wood BY-SA
  • Increased, mesotheliomas
1.29
490 Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms Karine Audouze All rights reserved
  • Ryanodine receptor activation
  • Inositol triphosphate receptor activation
  • Impairment, Learning and memory
  • decreased, Intellectual Quotient
  • increased, socio-economic burden
403 combined unhealthy lifestyle factors leading to metabolic syndrome Gillina Bezemer BY-SA
367 Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Jonathan Haselman BY-SA
  • Binding, Thyroid binding globulin in serum
  • Altered, Amphibian metamorphosis
366 Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Jonathan Haselman BY-SA
  • Binding, Transthyretin in serum
  • Altered, Amphibian metamorphosis
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser BY-SA
  • Activation, Constitutive androstane receptor
  • Increase, hepatocellular adenomas and carcinomas
Under Review 1.17
39 Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response Jessica Ponder BY-SA
  • Covalent Binding, Protein
  • Increase, Allergic Respiratory Hypersensitivity Response
Under Development 1.20
40 Covalent Protein binding leading to Skin Sensitisation Undefined BY-SA
  • Covalent Binding, Protein
  • sensitisation, skin
WPHA/WNT Endorsed 1.1
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Kellie Fay BY-SA
  • Inhibition, Cyclooxygenase 1 activity
  • Increased Mortality
  • Decrease, Population growth rate
1.29
28 Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve BY-SA
  • Inhibition, Cyclooxygenase activity
  • N/A, Reproductive failure
1.29
63 Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt BY-SA
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
1.29
100 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Dalma Martinovic-Weigelt BY-SA
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
1.29
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt BY-SA
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
1.29
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt BY-SA
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
1.29
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt BY-SA
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
1.29
434 CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects Job Berkhout All rights reserved
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders BY-SA
  • CYP2E1 Activation
  • Protein Adduct Formation
  • Neurodegeneration
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster BY-SA
  • Activation of Cyp2E1
  • Liver Cancer
WPHA/WNT Endorsed 1.24
368 Cytochrome oxidase inhibition leading to olfactory nasal lesions Katy Goyak BY-SA
  • Inhibition, cytochrome oxidase
  • Increase, Site of Contact Nasal Tumors
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood BY-SA
  • Increase, Cytotoxicity (club cells)
  • Increase, Adenomas/carcinomas (bronchioloalveolar)
1.29
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood BY-SA
  • Increase, Cytotoxicity (tubular epithelial cells)
  • Increase, Adenomas/carcinomas (renal tubular)
1.29
86 Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Carlie LaLone BY-SA
  • impaired, Larval development
  • Death/Failure, Colony
1.29
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Charles Wood BY-SA
  • Decreased, Androgen receptor activity
  • Increase, Leydig cell tumors
1.29
502 Decrease, cholesterol synthesis leads to orofacial clefting Jacob Reynolds All rights reserved
  • Orofacial clefting
Under Development 1.101
491 Decrease, GLI1/2 target gene expression leads to orofacial clefting Jacob Reynolds All rights reserved
  • Decrease, GLI1/2 target gene expression
  • Orofacial clefting
Under Development 1.101
392 Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation Penny Nymark BY-SA
  • Fibrinolysis, decreased
  • Bradykinin system, hyperactivated
  • Hyperinflammation
Under Development 1.96
528 Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis John Frisch BY-SA
  • Malformation, cryptorchidism - maldescended testis
539 Decreased Sodium/Potassium ATPase activity leads to Heart failure John Frisch BY-SA
  • Decreased Na/K ATPase activity
  • Heart failure
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA
  • anogenital distance (AGD), decreased
Under Development 1.90
527 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased John Frisch BY-SA
  • Hypospadias, increased
526 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis John Frisch BY-SA
  • Impaired, Spermatogenesis
158 Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA
  • Inhibition, Deiodinase 1
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
157 Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen BY-SA
  • Inhibition, Deiodinase 1
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
156 Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA
  • Inhibition, Deiodinase 2
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
155 Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen BY-SA
  • Inhibition, Deiodinase 2
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
510 Demethylation of PPAR promotor leading to vascular disrupting effects Yanhong Wei All rights reserved
  • peroxisome proliferator activated receptor promoter demethylation
  • Increase, Vascular disrupting effects
432 Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Dag Anders Brede All rights reserved
  • Deposition of Energy
  • Acute Myeloid Leukemia
483 Deposition of Energy Leading to Learning and Memory Impairment Vinita Chauhan All rights reserved
  • Deposition of Energy
  • Impairment, Learning and memory
272 Deposition of energy leading to lung cancer Vinita Chauhan BY-SA
  • Deposition of Energy
  • Increase, lung cancer
WPHA/WNT Endorsed 1.56
482 Deposition of energy leading to occurrence of bone loss Vinita Chauhan All rights reserved
  • Deposition of Energy
  • Occurrence, Bone Loss
478 Deposition of energy leading to occurrence of cataracts Vinita Chauhan All rights reserved
  • Deposition of Energy
  • Occurrence of Cataracts
299 Deposition of energy leading to population decline via DNA oxidation and follicular atresia You Song BY-SA
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
311 Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis You Song BY-SA
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
216 Deposition of energy leading to population decline via DNA strand breaks and follicular atresia Knut Erik Tollefsen BY-SA
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
238 Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis Knut Erik Tollefsen BY-SA
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
470 Deposition of energy leads to vascular remodeling Vinita Chauhan All rights reserved
  • Deposition of Energy
  • Occurrence, Vascular Remodeling
388 Deposition of ionising energy leading to population decline via programmed cell death Knut Erik Tollefsen BY-SA
  • Deposition of Energy
  • Decrease, Reproduction
  • Decrease, Population growth rate
387 Deposition of ionising energy leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen BY-SA
  • Deposition of Energy
  • Decrease, Reproduction
  • Decrease, Population growth rate
461 Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis Knut Erik Tollefsen BY-SA
435 Deposition of ionising energy leads to population decline via pollen abnormal Li Xie BY-SA
  • Deposition of Energy
  • Decrease, Reproduction
  • Decreased, Population trajectory
386 Deposition of ionizing energy leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA
  • Deposition of Energy
  • Decrease, Reproduction
  • Decrease, Population growth rate
396 Deposition of ionizing energy leads to population decline via impaired meiosis Erica Maremonti All rights reserved
  • Deposition of Ionizing Energy
  • Decrease of egg production and cummulative fecundity
  • Decrease, Reproduction
  • Decreased, Population size
43 Disruption of VEGFR Signaling Leading to Developmental Defects Undefined BY-SA
  • Inhibition, VegfR2
  • Increased, Developmental Defects
WPHA/WNT Endorsed 1.6
472 DNA adduct formation leading to kidney failure Manoe Janssen BY-SA
240 DNA Adducts Leading to Liver Hemangiosarcoma Undefined BY-SA
336 DNA methyltransferase inhibition leading to population decline (1) You Song BY-SA
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
337 DNA methyltransferase inhibition leading to population decline (2) You Song BY-SA
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
338 DNA methyltransferase inhibition leading to population decline (3) You Song BY-SA
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
339 DNA methyltransferase inhibition leading to population decline (4) You Song BY-SA
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
340 DNA methyltransferase inhibition leading to transgenerational effects (1) You Song BY-SA
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity (F3)
  • Decrease, Population growth rate
341 DNA methyltransferase inhibition leading to transgenerational effects (2) You Song BY-SA
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity (F3)
  • Decrease, Population growth rate
466 Doda decarboxylase leading to mortality Donggon Yoo BY-SA
  • Decrease, Tyrosine
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA
  • Inhibition, Dual oxidase
  • Altered, Amphibian metamorphosis
1.29
377 Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) Gillina Bezemer BY-SA
  • Prolonged TLR9 activation
  • Multi Organ Failure involving Acute Respiratory Distress Syndrome
  • Increased Mortality
378 Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Gillina Bezemer BY-SA
  • Toll Like Receptor (TLR) Dysregulation
167 Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Charles Wood BY-SA
  • prepubertal increase, Estrogen receptor (ER) activity
  • Increased, adenosquamous carcinomas of endometrium
1.29
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman BY-SA
Under Development 1.79
4 Ecdysone receptor agonism leading to incomplete ecdysis associated mortality Knut Erik Tollefsen BY-SA
  • Increase, Ecdysone receptor agonism
  • Increase, Mortality
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich BY-SA
  • Activation, EGFR
  • Decrease, Lung function
Under Development 1.51
269 Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild BY-SA
270 Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild All rights reserved
310 Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering BY-SA
  • Activation, AhR
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic BY-SA
  • Endocytotic lysosomal uptake
  • N/A, Liver fibrosis
Under Review 1.47
530 Endocytotic lysosomal uptake leads to intestinal barrier disruption Laure-Alix Clerbaux All rights reserved
  • Endocytotic lysosomal uptake
  • Intestinal barrier, disruption
412 Endothelial cell dysfunction leading to thromboinflammation Luigi Margiotta-Casaluci All rights reserved
  • Thromboinflammation, Increased
Under Development 1.96
473 Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin Danielle Beaton BY-SA
  • Deposition of Energy
  • Decrease, Growth
  • Decreased, Reproductive Success
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Charles Wood BY-SA
  • Increase, Adenomas/carcinomas (follicular cell)
1.29
72 Epigenetic modification of PPARG leading to adipogenesis Michelle Angrish BY-SA
  • peroxisome proliferator activated receptor promoter demethylation
  • chronic high fat diet
  • obesity
1.29
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood BY-SA
  • Increase, Cytotoxicity (epithelial cells)
  • Increase, Papillomas/carcinomas (squamous cells)
1.29
53 ER agonism leading to reduced survival due to renal failure Undefined BY-SA
  • Agonism, Estrogen receptor
1.29
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Undefined BY-SA
  • Agonism, Estrogen receptor
  • skewed, sex ratio
1.29
199 ER mediated breast cancer AOP Molly M Morgan BY-SA
493 ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity Min Ji Kim All rights reserved
  • Estrogen receptor alpha inactivation
  • Metabolically unhealthy Obesity
497 ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome Min Ji Kim All rights reserved
  • Estrogen receptor alpha inactivation
  • Insulin resistance, increased
  • Metabolic syndrome
521 Essential element imbalance leads to reproductive failure via oxidative stress Travis Karschnik BY-SA
  • Increased, essential element imbalance
  • Decreased, Viable Offspring
522 Estrogen antagonism leading to increased risk of autism-like behavior Kanglong Cui Open for adoption
  • Antagonism, Estrogen receptor
  • autism-like behavior
146 Estrogen Receptor Activation and Female Precocious Puberty Undefined BY-SA
1.29
200 Estrogen receptor activation leading to breast cancer Molly M Morgan Open for adoption
  • Activation, Estrogen receptor
  • N/A, Breast Cancer
536 Estrogen receptor agonism leading to reduced survival and population growth due to renal failure BY-SA
  • Agonism, Estrogen receptor
29 Estrogen receptor agonism leading to reproductive dysfunction Undefined BY-SA
  • Agonism, Estrogen receptor
  • Decrease, Population growth rate
  • Altered, Reproductive behaviour
  • Altered, Larval development
  • Impaired development of, Reproductive organs
1.29
537 Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver Jason M. O'Brien BY-SA
  • Agonism, Estrogen receptor
  • Reduction, Cumulative fecundity and spawning
445 Estrogen Receptor Alpha Agonism leads to Impaired Reproduction John Hoang BY-SA
  • Activation, estrogen receptor alpha
  • Impaired, Reproduction
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve BY-SA
  • Antagonism, Estrogen receptor
  • Decrease, Population growth rate
Under Review 1.12
95 Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Kellie Fay BY-SA
  • Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
  • Reduced, survival
1.29
501 Excessive iron accumulation leading to neurological disorders Young Jun Kim Open for adoption
  • Increased intracelluar Iron accumulation
  • Neurological disorder
327 Excessive reactive oxygen species production leading to mortality (1) You Song BY-SA
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
328 Excessive reactive oxygen species production leading to mortality (2) You Song BY-SA
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
329 Excessive reactive oxygen species production leading to mortality (3) You Song BY-SA
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
330 Excessive reactive oxygen species production leading to mortality (4) You Song BY-SA
  • Increase, Reactive Oxygen Species production
  • Increase, Mortality
331 Formation of DNA photoproducts leading to growth inhibition (1) You Song BY-SA
  • Increase, Formation of DNA photoproducts
  • Increase, Mortality
332 Formation of DNA photoproducts leading to growth inhibition (2) You Song BY-SA
333 Formation of DNA photoproducts leading to growth inhibition (3) You Song BY-SA
409 Frustrated phagocytosis leads to malignant mesothelioma Penny Nymark BY-SA
  • Frustrated phagocytosis
  • Increased, mesotheliomas
303 Frustrated phagocytosis-induced lung cancer Carole Seidel BY-SA
  • Frustrated phagocytosis
  • Lung cancer
Under Development 1.86
401 G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects Fei Li BY-SA
  • protein-coupled estrogen receptor 1 (GPER) activation
  • N/A, Steatohepatisis
217 Gastric ulcer formation Lyle Burgoon Open for adoption
  • Inhibit, gastric ulcer formation
  • Activated, gastric ulcer formation
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Undefined BY-SA
  • Glucocorticoid Receptor Agonist, Activation
  • impaired, Fertility
1.29
318 Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi BY-SA
  • Activation, Glucocorticoid Receptor
  • Increased, Liver Steatosis
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone BY-SA
  • Activation, Glucocorticoid Receptor
  • Increased, Disease susceptibility
1.29
334 Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Alexander Cole BY-SA
  • Activation, Glucocorticoid Receptor
  • Decrease, Population growth rate
113 Glutamate-gated chloride channel activation leading to acute mortality Helen Poynton BY-SA
  • Activation, Glutamate-gated chloride channel
  • Increased Mortality
  • Decreased, population 1
1.29
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen BY-SA
  • Activation, Glutamate-gated chloride channels
  • Increased Mortality
492 Glutathione conjugation leading to reproductive dysfunction via oxidative stress Leonardo Vieira All rights reserved
  • Conjugation, GSH
  • impaired, Fertility
524 Gluten intake leading to celiac disease example test - under development Pablo Rodriguez Fernandez All rights reserved
168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Charles Wood BY-SA
  • Increased, Adenomas/carcinomas (mammary)
1.29
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Charles Wood BY-SA
  • Increased, adenomas (pituitary)
1.29
410 GSK3beta inactivation leading to increased mortality via defects in developing inner ear Vid Modic BY-SA
  • GSK3beta inactivation
  • Increased Mortality
  • Decrease, Population growth rate
211 Handbook development AOP Dan Villeneuve BY-SA
1.29
229 Helicobacter pylori to gastric ulcer Lyle Burgoon Open for adoption
  • Helicobacter pylori infection
  • Activated, gastric ulcer formation
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman BY-SA
  • Activation, Hepatic nuclear receptor(s)
  • Altered, Amphibian metamorphosis
1.29
433 hERG channel blockade leading to sudden cardiac death Egemen Bilgin BY-SA
  • hERG channel blockade
  • Sudden cardiac death
99 Histamine (H2) receptor antagonism leading to reduced survival Kellie Fay BY-SA
  • Antagonism, Histamine Receptor (H2)
  • Decreased, survival
  • Increased, predation
1.29
212 Histone deacetylase inhibition leading to testicular atrophy Shihori Tanabe BY-SA
  • Histone deacetylase inhibition
  • Testicular atrophy
WPHA/WNT Endorsed 1.52
274 Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens BY-SA
  • Histone deacetylase inhibition
  • Facial cartilage structures are reduced in size and morphologically distorted
275 Histone deacetylase inhibition leads to neural tube defects Marvin Martens BY-SA
  • Histone deacetylase inhibition
  • Neural tube defects
124 HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay BY-SA
  • Inhibition, HMG-CoA reductase
  • Decrease, Fertility
1.29
59 HNF4alpha suppression leading to hepatic steatosis Michelle Angrish BY-SA
  • Suppression, HNF4alpha
1.29
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood BY-SA
  • Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
  • Increase, Papillomas/carcinomas (squamous cells)
1.29
384 Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Young Jun Kim BY-SA
  • Hyperactivation of ACE/Ang-II/AT1R axis
  • Chronic kidney disease
440 Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia Kalyan Gayen All rights reserved
  • Suppression, Estrogen receptor (ER) activity
  • Promotion, ovarian adenomas
  • Promotion, Ovarian Cancer
Under Development 1.104
278 IKK complex inhibition leading to liver injury Nanette Vrijenhoek BY-SA
  • Inhibition, IKK complex
  • Necrotic Tissue
  • Liver Injury
408 Imbalance in redox homeostasis leading to structural damage to tissues Fei Li BY-SA
362 Immune mediated hepatitis Jung-Hwa Oh BY-SA
  • benzoquinone imine and acylglucuronide metabolites
  • Immune mediated hepatitis
277 Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response Takao Ashikaga BY-SA
  • Impaired IL-1R1 signaling in T cell
  • Impairment, T-cell dependent antibody response
WPHA/WNT Endorsed 1.48
400 Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males Terje Svingen BY-SA
  • Increased (ectopic) all-trans retinoic acid concentration
  • Reduce, Sperm count
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm BY-SA
  • Increase, DNA damage
  • Increase, Mutations
  • Increased, Ductal Hyperplasia
  • N/A, Breast Cancer
Under Development 1.80
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood BY-SA
  • Increase, Dopaminergic activity
  • Increase, Endometrial adenocarcinomas
1.29
498 Increased LCN2/iron complex leading to neurological disorders Young Jun Kim Open for adoption
  • Increased LCN2/iron complex binds to SLC22A17 receptor in neuron
  • Neurological disorder
81 Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone BY-SA
  • Decrease, Number of worker bees
  • Death/Failure, Colony
1.29
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm BY-SA
  • Increase in reactive oxygen and nitrogen species (RONS)
  • Increase, DNA damage
  • Increase, Mutations
  • Increased, Ductal Hyperplasia
  • N/A, Breast Cancer
Under Development 1.80
488 Increased reactive oxygen species production leading to decreased cognitive function Eliska Kuchovska BY-SA
  • Increase, Reactive Oxygen Species production
  • Cognitive Function, Decreased
431 Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) Qi Wang BY-SA
  • Increase, TNF
  • Gestational diabetes mellitus
298 Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer Shihori Tanabe BY-SA
  • Increases in cellular reactive oxygen species
  • Chronic reactive oxygen species
  • Treatment-resistant gastric cancer
Under Review 1.58
349 Inhibition of 11β-hydroxylase leading to decresed population trajectory Young Jun Kim BY-SA
  • 11β-hydroxylase inhibition
  • Decrease, Population growth rate
Under Development 1.93
348 Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory Young Jun Kim BY-SA
  • Inhibition of 11β-HSD
  • Decrease, Population growth rate
Under Development 1.93
288 Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET BY-SA
  • Inhibition, Cytochrome P450 enzyme (CYP17A1) activity
  • Malformation, cryptorchidism - maldescended testis
289 Inhibition of 5α-reductase leading to impaired fecundity in female fish Young Jun Kim BY-SA
  • Inhibition, 5α-reductase
  • Decrease, Population growth rate
Under Development 1.81
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood BY-SA
  • Inhibition, 5α-reductase activity
  • Increase, Leydig cell tumors
1.29
398 Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary Terje Svingen BY-SA
  • Inhibition of ALDH1A (RALDH)
  • impaired, Fertility
Under Development 1.97
383 Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Young Jun Kim BY-SA
  • Induced dysregulation of ACE2
  • N/A, Liver fibrosis
Under Development 1.96
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Takumi Ohishi BY-SA
  • Inhibition, Calcineurin Activity
  • Impairment, T-cell dependent antibody response
WPHA/WNT Endorsed 1.38
276 Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens BY-SA
  • Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
  • Chemical induced Fanconi syndrome
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière BY-SA
  • CYP7B activity, inhibition
  • Decrease, Population growth rate
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière BY-SA
  • CYP7B activity, inhibition
  • Decrease, Population growth rate
301 Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim BY-SA
  • Inhibition of cystathionine beta-synthase
  • Impaired,anterior-posterior axis development
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon Open for adoption
  • Inhibition, Fatty Acid Beta Oxidation
  • N/A, Steatohepatisis
399 Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) Vid Modic BY-SA
  • Inhibition of Fyna
  • Increased Mortality
  • Decrease, Population growth rate
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Undefined BY-SA
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood BY-SA
  • Inhibition, Na+/I- symporter (NIS)
  • Increase, Adenomas/carcinomas (follicular cell)
1.29
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Yasuhiro Yoshida BY-SA
  • Inhibition of JAK3
  • Impairment of T-cell dependent antibody response
Under Development 1.74
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz Open for adoption
  • Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
  • Growth, reduction
  • Decreased, survival
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally BY-SA
  • Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)
  • Occurrence, Kidney toxicity
Under Development 1.43
437 Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity Baki Sadi BY-SA
  • Inhibition, Mitochondrial Electron Transport Chain Complexes
  • Occurrence, Kidney toxicity
Under Development 1.99
285 Inhibition of N-linked glycosylation leads to liver injury Marvin Martens BY-SA
  • Inhibition of N-linked glycosylation
  • Liver Injury
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price BY-SA
  • Inhibition, Na+/I- symporter (NIS)
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.28
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood BY-SA
  • Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
  • Increase, hepatocellular adenomas and carcinomas
1.29
436 Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries Gina Mennen BY-SA
  • Inhibition of ALDH1A (RALDH)
  • transposition of the great arteries
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Young Jun Kim BY-SA
  • Retinaldehyde dehydrogenase inhibition
  • Decrease, Population growth rate
Under Development 1.77
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron BY-SA
  • Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
  • Parkinsonian motor deficits
WPHA/WNT Endorsed 1.33
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood BY-SA
  • Thyroperoxidase, Inhibition
  • Increase, Adenomas/carcinomas (follicular cell)
1.29
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park BY-SA
  • Thyroperoxidase, Inhibition
  • Reduction, Cumulative fecundity and spawning
Under Development 1.59
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton BY-SA
  • Thyroperoxidase, Inhibition
  • Cognitive Function, Decreased
WPHA/WNT Endorsed 1.10
292 Inhibition of tyrosinase leads to decreased population in fish Young Jun Kim BY-SA
  • Inhibition of tyrosinase
  • Decrease, Population growth rate
Under Development 1.78
489 Inhibition of voltage-gated sodium channels leading to decreased cognition Eliska Kuchovska BY-SA
  • Binding to voltage-gated sodium channel
  • Cognitive Function, Decreased
451 Interaction with lung resident cell membrane components leads to lung cancer Penny Nymark BY-SA
  • Substance interaction with the lung resident cell membrane components
  • Lung cancer
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Kristie Sullivan BY-SA
  • Binding, Transthyretin in serum
  • Cognitive Function, Decreased
Under Development 1.41
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Undefined BY-SA
  • Decrease, Intracellular pH
  • Increase, Site of Contact Nasal Tumors
Under Review 2.7
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA
  • Inhibition, Iodotyrosine deiodinase (IYD)
  • Altered, Amphibian metamorphosis
1.29
444 Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability Deborah Oughton BY-SA
  • Deposition of Energy
  • Increase in reactive oxygen and nitrogen species (RONS)
  • Increase, DNA damage
  • Decrease, Population growth rate
441 Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation Olivier ARMANT BY-SA
  • Deposition of Energy
  • Increase risk, microcephaly
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen BY-SA
  • Activation, ionotropic GABA Receptor chloride channel
  • Increased Mortality
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi All rights reserved
  • Reproductive failure
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Knut Erik Tollefsen BY-SA
  • Activation, Juvenile hormone receptor
  • Increased, Male offspring
  • Decline, Population
  • Alteration, Food-web structures
128 Kidney dysfunction by decreased thyroid hormone Jung-Hwa Oh BY-SA
  • Thyroid hormone synthesis, Decreased
  • Occurrence, Kidney toxicity
Under Development 1.40
447 Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways Yann GUEGUEN BY-SA
  • Increased, Kidney Failure
33 Kidney toxicity induced by activation of 5HT2C Kevin Crofton Open for adoption
  • Activation, 5HT2c
  • Increased, Kidney Failure
467 Knickkopf leading to mortality Donggon Yoo BY-SA
  • Decrease, 20-hydroxyecdysone
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci All rights reserved
  • Blockade, L-Type Calcium Channels
  • Heart failure
Under Development 1.45
283 L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci All rights reserved
Under Development 1.45
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci All rights reserved
Under Development 1.45
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens BY-SA
  • Activation, Latent Transforming Growth Factor Beta 1
  • Pulmonary fibrosis
518 Liver X Receptor (LXR) activation leads to liver steatosis John Frisch BY-SA
  • Activation, LXR
  • Increased, Liver Steatosis
302 Lung surfactant function inhibition leading to decreased lung function Jorid Birkelund Sørli BY-SA
  • Inhibition of lung surfactant function
  • Decrease, Lung function
Under Development 1.87
309 Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim BY-SA
  • Antagonism,LH receptor
  • Decline, Population trajectory
34 LXR activation leading to hepatic steatosis Undefined BY-SA
  • Activation, LXR
  • peroxisome proliferator activated receptor promoter demethylation
  • N/A, Liver Steatosis
222 Mental stress to agitation Lyle Burgoon Open for adoption
  • Increased, glucocorticoid receptor activity
  • Increased, agitation
221 Mental stress to depression Lyle Burgoon Open for adoption
  • Increased, glucocorticoid receptor activity
  • Increased, depression
404 Metabolic Syndrome leading to Toll Like Receptor dysregulation Gillina Bezemer BY-SA
279 Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens BY-SA
  • Binding of microtubule stabilizing agents (MSA) to microtubules
  • Sensory axonal peripheral neuropathy
290 Mitochondrial ATP synthase antagonism leading to growth inhibition (1) You Song BY-SA
  • Increase, Mitochondrial ATP synthase antagonism
  • Decrease, Growth
291 Mitochondrial ATP synthase antagonism leading to growth inhibition (2) You Song BY-SA
  • Increase, Mitochondrial ATP synthase antagonism
  • Decrease, Growth
286 Mitochondrial complex III antagonism leading to growth inhibition (1) You Song BY-SA
  • Increase, Mitochondrial complex III antagonism
  • Decrease, Growth
287 Mitochondrial complex III antagonism leading to growth inhibition (2) You Song BY-SA
  • Increase, Mitochondrial complex III antagonism
  • Decrease, Growth
273 Mitochondrial complex inhibition leading to liver injury Wanda van der Stel BY-SA
  • Increase, Mitochondrial complex III antagonism
  • Mitochondrial Complex IV inhibition
  • Mitochondrial Complex V inhibition
  • Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
  • Inhibition, NADH-ubiquinone oxidoreductase (complex I)
  • Binding of inhibitor to mitochondrial complex III
  • Binding of inhibitor to mitochondrial complex IV
  • Binding of inhibitor to mitochondrial complex V
  • Necrotic Tissue
  • Liver Injury
480 Mitochondrial complexes inhibition leading to heart failure via decreased ATP production Alexandra Schaffert BY-SA
  • Inhibition, Mitochondrial Electron Transport Chain Complexes
  • Decrease Left Ventricular function
Under Development 1.102
479 Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress Sivakumar Murugadoss BY-SA
  • Inhibition, Mitochondrial Electron Transport Chain Complexes
  • Decrease Left Ventricular function
Under Development 1.102
373 Mitochondrial dysfunction to metabolic diseases Chander K. Negi BY-SA
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Undefined BY-SA
  • Decreased testosterone by the fetal Leydig cells, Increased corticosterone
  • Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
  • Decreased sperm quantity / quality in the adult, Decreased fertility
1.29
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Undefined BY-SA
  • Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
  • Decreased sperm quantity / quality in the adult, Decreased fertility
1.29
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Undefined BY-SA
  • Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol
  • Decreased Cholesterol, Decreased Uptake of Lipoproteins
  • Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
  • Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
1.29
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Undefined BY-SA
  • Decreased testosterone by the fetal Leydig cells, Increased estradiol
  • Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists
  • Decreased sperm quantity / quality in the adult, Decreased fertility
1.29
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Undefined BY-SA
  • Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
  • Decreased sperm quantity or quality in the adult, Decreased fertility
1.29
74 Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Undefined BY-SA
  • Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
  • Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
1.29
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Undefined BY-SA
  • Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
  • Decreased sperm quantity or quality in the adult, Decreased fertility
1.29
215 Molecular events lead to epilepsy Lyle Burgoon Open for adoption
  • Increase, seizure
  • Increased, hippocampal hyperdepolarization
  • Increased, epilepsy
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Timothy Allen BY-SA
  • Mu Opioid Receptor Agonism
  • Analgesia
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen BY-SA
  • Mu Opioid Receptor Agonism
  • Analgesia
516 Na+ /K+ -ATPase inhibition leading to hypertension Michelle Angrish All rights reserved
  • Decreased Na/K ATPase activity
  • Hypertension
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Jinhee Choi All rights reserved
  • Activation, NADPH Oxidase
  • Reproductive failure
35 Narcosis leading to respiratory failure Dries Knapen BY-SA
  • Accumulation, Biological membranes
Under Development 1.2
214 Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon Open for adoption
  • Increased, seizure
  • Increased, agitation
  • Increased, depression
  • Increase, hypertension
232 NFE2/Nrf2 repression to steatosis Lyle Burgoon Open for adoption
  • NFE2/Nrf2 repression
  • Increased, Liver Steatosis
61 NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish BY-SA
  • Activation, NRF2
  • Activation, NR1H4
  • Increased, Liver Steatosis
1.29
77 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Carlie LaLone BY-SA
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
1.29
87 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone BY-SA
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
1.29
88 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Carlie LaLone BY-SA
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
1.29
78 Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Carlie LaLone BY-SA
  • Activation, Nicotinic acetylcholine receptor
  • impaired, Larval development
  • Death/Failure, Colony
1.29
90 Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Carlie LaLone BY-SA
  • Activation, Nicotinic acetylcholine receptor
  • impaired, Larval development
  • Death/Failure, Colony
1.29
80 Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Carlie LaLone BY-SA
  • Activation, Nicotinic acetylcholine receptor
  • Decrease, Number of worker bees
  • impaired, Hive thermoregulation
  • Death/Failure, Colony
1.29
79 Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Carlie LaLone BY-SA
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
1.29
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Carlie LaLone BY-SA
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
1.29
89 Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Carlie LaLone BY-SA
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
1.29
184 Nosema infection causes abnormal role change that leads to colony loss/failure Carlie LaLone BY-SA
  • Death/Failure, Colony
1.29
183 Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone BY-SA
  • Death/Failure, Colony
1.29
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish BY-SA
  • Activation, PXR/SXR
  • Increased, Liver Steatosis
1.29
58 NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish BY-SA
  • Suppression, Constitutive androstane receptor, NR1l3
  • Inhibition, PPAR alpha
  • Activation, LXR
  • peroxisome proliferator activated receptor promoter demethylation
  • Increased, Liver Steatosis
1.29
509 Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction Yanhong Wei All rights reserved
  • NFE2/Nrf2 repression
  • Increase, Vascular disrupting effects
508 Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway Yanhong Wei All rights reserved
  • NFE2/Nrf2 repression
  • Increase, Vascular disrupting effects
507 Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway Yanhong Wei All rights reserved
  • NFE2/Nrf2 repression
  • Increase, Vascular disrupting effects
227 NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon Open for adoption
  • Reduced, PTGS1 function
  • Activated, gastric ulcer formation
228 NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon Open for adoption
  • Reduced, PTGS2 function
  • Activated, gastric ulcer formation
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay BY-SA
  • Inhibition, organic anion transporter 1 (OAT1)
  • Increased Mortality
  • Decrease, Population growth rate
1.29
405 Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function SAROJ AMAR BY-SA
  • Acetylcholinesterase (AchE) Inhibition
  • Cognitive Function, Decreased
413 Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Zarin Hossain BY-SA
  • Oxidation, Glutathione (To be considered with MIE)
  • Increased Mortality
31 Oxidation of iron in hemoglobin leading to hematotoxicity Undefined Open for adoption
  • N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)
  • N/A, Cyanosis occurs
Under Development 1.16
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk BY-SA
  • Increase, Oxidative damage to DNA
  • Increase, Mutations
  • Increase, Chromosomal aberrations
WPHA/WNT Endorsed 1.76
540 Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production Kevin Brix All rights reserved
  • Increased, Reactive oxygen species
411 Oxidative stress Leading to Decreased Lung Function Karsta Luettich BY-SA
  • Oxidative Stress
  • Decrease, Lung function
424 Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Karsta Luettich BY-SA
  • Oxidative Stress
  • Decrease, Lung function
425 Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Karsta Luettich BY-SA
  • Oxidative Stress
  • Decrease, Lung function
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Undefined BY-SA
192 Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA
  • Inhibition, Pendrin
  • Altered, Amphibian metamorphosis
1.29
149 Peptide Oxidation Leading to Hypertension Frazer Lowe BY-SA
  • Peptide Oxidation
  • Hypertension
Under Development 1.50
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno BY-SA
  • Activation, PXR/SXR
Under Development 2.5
529 Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis Erik Mylroie BY-SA
  • Stressor binding PPAR isoforms
  • Increased, Liver Steatosis
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish BY-SA
  • Decreased, PPAR-alpha activation
  • Decreased, PPAR-beta activation
  • Decreased, PPAR-gamma activation
  • Increased, Liver Steatosis
1.29
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi All rights reserved
  • Inactivation of PPARγ
  • Lung fibrosis
Under Development 1.54
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi All rights reserved
  • Hepatotoxicity
130 Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity Jung-Hwa Oh BY-SA
  • Inhibition, Phospholipase A
  • Formation, Liver fibrosis
Under Development 1.39
371 Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone You Song BY-SA
369 Photosystem II antagonism leading to growth inhibition via oxidative damage You Song BY-SA
370 Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis You Song BY-SA
514 PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV Hui Li All rights reserved
446 PM-related Adverse outcome pathway frameworks on various systems Tianyu Li BY-SA
454 PM2.5-related AOP frameworks on liver diseases Zhou Du BY-SA
166 PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Charles Wood BY-SA
  • Increased, Pancreatic acinar tumors
1.29
323 PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone Jennifer Olker BY-SA
  • Activation, PPARα
  • Decreased, Viable Offspring
  • Decrease, Population growth rate
421 PPARG activation leading to intrahepatic cholestasis Yuan Jin All rights reserved
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Charles Wood BY-SA
  • Activation of specific nuclear receptors, PPAR-gamma activation
1.29
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard BY-SA
  • Activation, PPARα
  • impaired, Fertility
  • Malformation, Male reproductive tract
Under Review 1.21
37 PPARα activation leading to hepatocellular adenomas and carcinomas in rodents Chris Corton BY-SA
  • Activation, PPARα
  • Increase, hepatocellular adenomas and carcinomas
Under Development 1.17
51 PPARα activation leading to impaired fertility in adult male rodents Elise Grignard BY-SA
  • Activation, PPARα
  • impaired, Fertility
Under Development 1.21
517 Pregnane X Receptor (PXR) activation leads to liver steatosis John Frisch BY-SA
  • Activation, Pregnane-X receptor, NR1l2
  • Increased, Liver Steatosis
230 presynaptic neuron 1 activation to epilepsy Lyle Burgoon Open for adoption
  • Activated, presynaptic neuron 1
  • Increased, epilepsy
231 presynaptic neuron 2 repression to epilepsy Lyle Burgoon Open for adoption
  • Reduced, presynaptic neuron 2 activity
  • Increased, epilepsy
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt BY-SA
  • Inhibition, Prolyl hydroxylases
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
1.29
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann BY-SA
  • Alkylation, Protein
  • N/A, Liver fibrosis
WPHA/WNT Endorsed 1.14
185 Queen egg-laying decrease leads to colony loss/failure Carlie LaLone BY-SA
  • Death/Failure, Colony
1.29
513 Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway John Frisch BY-SA
  • Increased, Reactive oxygen species
  • Increase, Cancer
505 Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway John Frisch BY-SA
  • Increased, Reactive oxygen species
  • Increase, Cancer
453 Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population Ruiyang Ding BY-SA
438 reactive oxygen species generation leading to increased cardiovascular morbidity and mortality Yu Yang All rights reserved
469 Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population Ruiyang Ding BY-SA
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally BY-SA
  • Binding of substrate, endocytic receptor
  • Occurrence, Kidney toxicity
Under Development 1.43
512 Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level Ana-Andreea Cioca All rights reserved
321 Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker BY-SA
525 Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption
  • Binding of antagonist to thyroid hormone receptor
  • Binding of antagonist to glucocorticoid hormone receptor
  • Binding of (ant)agonist to liver X receptor
  • Binding of (ant)agonist to peroxisome proliferator–activated receptor alpha
  • Impairment, Learning and memory
245 Reduction in photophosphorylation leading to growth inhibition in aquatic plants Knut Erik Tollefsen BY-SA
  • Increase, Uncoupling of photophosphorylation
  • Decrease, Growth
258 Renal protein alkylation leading to kidney toxicity Angela Mally BY-SA
  • Alkylation, Protein
  • Occurrence, Kidney toxicity
Under Development 1.43
532 Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function Diana Lupu Open for adoption
  • Agonism, Retinoic acid receptor
  • Locomotor function. Impaired
520 Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption
  • Agonism, Retinoic acid receptor
  • Impairment, Learning and memory
523 Retinoic acid receptor agonism during neurodevelopment leading to microcephaly Diana Lupu Open for adoption
  • Agonism, Retinoic acid receptor
  • Increase risk, microcephaly
533 Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption
  • Antagonism, Retinoic acid receptors
  • Impairment, Learning and memory
448 ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality Ruiyang Ding BY-SA
342 S-adenosylmethionine depletion leading to population decline (1) You Song BY-SA
  • Inhibition, Chitin synthase 1
  • Increase, Mortality
343 S-adenosylmethionine depletion leading to population decline (2) You Song BY-SA
  • Increase, Sulfonylurea receptor binding
  • Increase, Mortality
406 SARS-CoV-2 infection leading to hyperinflammation Hasmik Yepiskoposyan All rights reserved
  • Binding to ACE2
  • Hyperinflammation
407 SARS-CoV-2 infection leading to pyroptosis Hasmik Yepiskoposyan All rights reserved
  • Binding to ACE2
  • Pyroptosis
394 SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) Sandra Coecke BY-SA
  • Binding to ACE2
  • impaired olfactory function (anosmia)
Under Development 1.96
426 SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. Evangelos-Panagiotis Daskalopoulos BY-SA
  • Binding to ACE2
  • Myocardial Infarction
259 Sensitization induction of the intestinal tract by food proteins Erwin L Roggen BY-SA
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Timothy Allen BY-SA
  • Serotonin 1A Receptor Agonism
  • Anti-depressant Activity
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Timothy Allen BY-SA
  • Serotonin 1A Receptor Agonism
  • Anti-depressant Activity
225 Serotonin transporter activation to agitation Lyle Burgoon Open for adoption
  • Increased, agitation
224 Serotonin transporter activation to depression Lyle Burgoon Open for adoption
  • Increased, serotonin transporter activity
  • Increased, depression
223 Serotonin transporter activation to seizure Lyle Burgoon Open for adoption
  • Increased, serotonin transporter activity
  • Increased, seizure
197 Sodium channel (Nav1.1) inhibition leading to population decline Kellie Fay BY-SA
  • Inhibition, sodium channel
1.29
94 Sodium channel inhibition leading to congenital malformations Kellie Fay BY-SA
  • Inhibition, sodium channel
  • Increased, amputations
1.29
93 sodium channel inhibition leading to increased predation Kellie Fay BY-SA
  • Inhibition, sodium channel
  • Increased, predation
1.29
91 Sodium channel inhibition leading to reduced survival Kellie Fay BY-SA
  • Inhibition, sodium channel
  • Reduced, feeding 1
  • Increased, predation
  • Reduced, survival
1.29
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert BY-SA
  • Inhibition, Na+/I- symporter (NIS)
  • Cognitive Function, Decreased
1.29
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA
  • Inhibition, Na+/I- symporter (NIS)
  • Altered, Amphibian metamorphosis
1.29
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon Open for adoption
  • Decreased, serotonin transporter activity
  • Increase, hypertension
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Hiroyuki Komatsu BY-SA
  • Stimulation, TLR7/8
  • Psoriatic skin disease
Under Development 1.75
237 Substance interaction with lung resident cell membrane components leading to atherosclerosis Ulla Vogel BY-SA
  • Substance interaction with the lung resident cell membrane components
  • Atherosclerosis
Under Development 1.55
173 Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis Sabina Halappanavar All rights reserved
  • Substance interaction with the lung resident cell membrane components
  • Pulmonary fibrosis
WPHA/WNT Endorsed 1.32
534 Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress Xavier COUMOUL All rights reserved
  • Succinate dehydrogenase, inhibited
  • Increase, Cancer
474 Succinate dehydrogenase inactivation leading to cancer Sylvie Bortoli BY-SA
  • Succinate dehydrogenase, inhibited
  • Increase, Cancer
Under Development 1.106
457 Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine Simon Thomas Open for adoption
  • Succinate dehydrogenase, inhibited
  • Insulin resistance, increased
361 Sulfonylureareceptor binding leading to mortality Simon Schmid All rights reserved
  • Increase, Sulfonylurea receptor binding
  • Increase, Mortality
Under Development 1.94
504 SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level Ana-Andreea Cioca All rights reserved
  • Inhibition of Sulfotransferase E1 (SULT1E1)
85 Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone BY-SA
  • Decrease, Number of worker bees
  • Death/Failure, Colony
1.29
84 Suppression of immune system contributes to impaired development and leads to colony loss/failure Carlie LaLone BY-SA
  • Decrease, Number of worker bees
  • impaired, Hive thermoregulation
  • Death/Failure, Colony
1.29
41 Sustained AhR Activation leading to Rodent Liver Tumours Undefined BY-SA
  • Activation, Long term AHR receptor driven direct and indirect gene expression changes
  • Formation, Hepatocellular and Bile duct tumors
Under Review 1.7
304 TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee All rights reserved
  • Inhibition, TBX1
  • Anomalies, Congenital cardiac conotruncal
375 test AOP Kevin Crofton BY-SA
511 The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects Yanhong Wei All rights reserved
  • Increase, Reactive Oxygen Species production
  • Increase, Vascular disrupting effects
463 The AOP framwork on silica nanopariticles induced hepatoxicity Tianyu Li BY-SA
324 Thermal stress leading to population decline (1) You Song BY-SA
  • Mitochondrial dysfunction
  • Decrease, Fecundity
  • Decrease, Population growth rate
325 Thermal stress leading to population decline (2) You Song BY-SA
  • Mitochondrial dysfunction
  • Decrease, Fecundity
  • Decrease, Population growth rate
326 Thermal stress leading to population decline (3) You Song BY-SA
  • Mitochondrial dysfunction
  • Decrease, Fecundity
  • Decrease, Population growth rate
485 Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition Eliska Kuchovska BY-SA
  • Antagonism, Thyroid Receptor
  • Cognitive Function, Decreased
402 Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain Katherine (Katie) O'Shaughnessy BY-SA
  • Thyroperoxidase, Inhibition
  • Periventricular heterotopia formation
  • Increase, seizure
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton BY-SA
  • Antagonism, Thyroid Receptor
  • Cognitive Function, Decreased
Under Development 1.84
175 Thyroperoxidase inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA
  • Thyroperoxidase, Inhibition
  • Altered, Amphibian metamorphosis
1.29
365 Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning Lucia Vergauwen All rights reserved
  • Thyroperoxidase, Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
Under Development 1.35
363 Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure Lucia Vergauwen BY-SA
  • Thyroperoxidase, Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
Under Review 1.35
364 Thyroperoxidase inhibition leading to altered visual function via decreased eye size Lucia Vergauwen All rights reserved
  • Thyroperoxidase, Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
Under Development 1.35
159 Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA
  • Thyroperoxidase, Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
347 Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Seokjoo Yoon BY-SA
  • Toll-like receptor 4 activation
  • Inactivation of PPARγ
  • Pulmonary fibrosis
316 Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada BY-SA
  • Trypsin inhibition
  • Pancreatic acinar cell tumors
Under Development 1.60
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA
  • Inhibition, Deiodinase 1
  • Altered, Amphibian metamorphosis
1.29
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA
  • Inhibition, Deiodinase 2
  • Altered, Amphibian metamorphosis
1.29
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA
  • Inhibition, Deiodinase 3
  • Altered, Amphibian metamorphosis
1.29
263 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation You Song BY-SA
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
WPHA/WNT Endorsed 1.92
264 Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death You Song BY-SA
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity You Song BY-SA
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion You Song BY-SA
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium You Song BY-SA
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
268 Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling You Song BY-SA
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
487 Unknown MIE altering cholesterol metabolism leading to decreased cognition Eliska Kuchovska BY-SA
  • Unknown, MIE
  • Cognitive Function, Decreased
186 unknown MIE leading to renal failure and mortality Kellie Fay BY-SA
  • Unknown, MIE
  • Increased Mortality
1.29
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt BY-SA
  • modulation, Unknown
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
1.29
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Open for adoption
  • Activation, Pregnane-X receptor, NR1l2
  • Loss, Cochlear function
Under Development 1.9
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood BY-SA
  • Increase, Urinary bladder calculi
  • Increase, Adenomas/carcinomas (urothelial)
1.29
471 Various neuronal effects induced by elavl3, sox10, and mbp Donggon Yoo BY-SA
  • Increase, CNS Neural cell death
  • impaired, Learning and memory
  • Encephalitis
  • Parkinsonian motor deficits
  • Increase, seizure
  • Increased, epilepsy
  • Increase, Mortality
  • Inhibition, Feeding
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Carlie LaLone BY-SA
  • Death/Failure, Colony
1.29
179 Varroa mite infestation increases virus levels leading to colony loss/failure Carlie LaLone BY-SA
  • Death/Failure, Colony
1.29
531 VEGFR inhibition leading to Keratinocyte differentiation-associate Hand-foot skin reaction Hui Li All rights reserved
385 Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation Julija Filipovska BY-SA
  • Binding to ACE2
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Jeanelle Martinez BY-SA
  • TRPA1 activation, TRPA1 Receptor
  • Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
  • Irritation of nasal mucosa inducing sneeze reflex
  • Increased Respiratory irritability and Chronic Cough,
182 Weather event contributes abnormal foraging leading to colony loss/failure Carlie LaLone BY-SA
  • Death/Failure, Colony
1.29
181 Weather event contributes to colony loss/failure Carlie LaLone BY-SA
  • Death/Failure, Colony
1.29
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Undefined BY-SA
  • Inhibition, Inhibition of Dopamine-beta-hydroxylase
  • Decreased, Decreased fecundity
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280 α-diketone-induced bronchiolitis obliterans Marvin Martens BY-SA
  • Interaction of α-diketones with arginine residues
  • Bronchiolitis obliterans