API

Event: 239

Key Event Title

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Activation, Pregnane-X receptor, NR1l2

Short name

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Activation, Pregnane-X receptor, NR1l2

Biological Context

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Level of Biological Organization
Molecular

Cell term

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Cell term
eukaryotic cell


Organ term

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Key Event Components

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Process Object Action
signaling nuclear receptor subfamily 1 group I member 2 increased
signaling nuclear receptor subfamily 1 group I member 3 increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Nuclear receptor induced TH Catabolism and Developmental Hearing Loss MolecularInitiatingEvent

Stressors

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Rattus norvegicus Rattus norvegicus High NCBI
Mus musculus Mus musculus High NCBI
Homo sapiens Homo sapiens Moderate NCBI

Life Stages

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Sex Applicability

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Key Event Description

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How It Is Measured or Detected

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Domain of Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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