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Aop: 14

AOP Title

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Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility

Short name:

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Glucocorticoid Receptor, Activation

Graphical Representation

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Click to download graphical representation template

Authors

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Carlie A. LaLone, University of Minnesota, Water Resources Center, lalone.carlie@epa.gov

Point of Contact

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Carlie LaLone   (email point of contact)

Contributors

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  • Carlie LaLone

Status

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Author status OECD status OECD project SAAOP status
Open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on August 19, 2019 14:30

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Revision dates for related pages

Page Revision Date/Time
Activation, Glucocorticoid Receptor September 16, 2017 10:14
Inhibition, Nuclear factor kappa B (NF-kB) November 18, 2019 00:47
Suppression, Inflammatory cytokines December 03, 2016 16:37
Decreased, Lymphocytes December 03, 2016 16:37
Induction, IKB inhibitory protein September 16, 2017 10:14
Increased, Disease susceptibility December 03, 2016 16:33
Suppression, Immune system December 03, 2016 16:37
Activation, Glucocorticoid Receptor leads to Induction, IKB inhibitory protein December 03, 2016 16:37
Induction, IKB inhibitory protein leads to Inhibition, Nuclear factor kappa B (NF-kB) December 03, 2016 16:37
Inhibition, Nuclear factor kappa B (NF-kB) leads to Suppression, Inflammatory cytokines December 03, 2016 16:37
Suppression, Inflammatory cytokines leads to Decreased, Lymphocytes December 03, 2016 16:37
Decreased, Lymphocytes leads to Suppression, Immune system December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 122 Activation, Glucocorticoid Receptor Activation, Glucocorticoid Receptor
2 KE 202 Inhibition, Nuclear factor kappa B (NF-kB) Inhibition, Nuclear factor kappa B (NF-kB)
3 KE 152 Suppression, Inflammatory cytokines Suppression, Inflammatory cytokines
4 KE 168 Decreased, Lymphocytes Decreased, Lymphocytes
5 KE 145 Induction, IKB inhibitory protein Induction, IKB inhibitory protein
6 KE 403 Suppression, Immune system Suppression, Immune system
7 AO 323 Increased, Disease susceptibility Increased, Disease susceptibility

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Activation, Glucocorticoid Receptor leads to Induction, IKB inhibitory protein adjacent
Induction, IKB inhibitory protein leads to Inhibition, Nuclear factor kappa B (NF-kB) adjacent
Inhibition, Nuclear factor kappa B (NF-kB) leads to Suppression, Inflammatory cytokines adjacent
Suppression, Inflammatory cytokines leads to Decreased, Lymphocytes adjacent
Decreased, Lymphocytes leads to Suppression, Immune system adjacent

Network View

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Stressors

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Life Stage Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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