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Aop: 14

AOP Title

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Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility

Short name:

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Glucocorticoid Receptor, Activation

Graphical Representation

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Click to download graphical representation template

Authors

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Carlie A. LaLone, University of Minnesota, Water Resources Center, lalone.carlie@epa.gov

Point of Contact

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Carlie LaLone   (email point of contact)

Contributors

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  • Carlie LaLone

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Activation, Glucocorticoid Receptor September 16, 2017 10:14
Inhibition, Nuclear factor kappa B (NF-kB) September 16, 2017 10:14
Suppression, Inflammatory cytokines December 03, 2016 16:37
Decreased, Lymphocytes December 03, 2016 16:37
Induction, IKB inhibitory protein September 16, 2017 10:14
Increased, Disease susceptibility December 03, 2016 16:33
Suppression, Immune system December 03, 2016 16:37
Activation, Glucocorticoid Receptor leads to Induction, IKB inhibitory protein December 03, 2016 16:37
Induction, IKB inhibitory protein leads to Inhibition, Nuclear factor kappa B (NF-kB) December 03, 2016 16:37
Inhibition, Nuclear factor kappa B (NF-kB) leads to Suppression, Inflammatory cytokines December 03, 2016 16:37
Suppression, Inflammatory cytokines leads to Decreased, Lymphocytes December 03, 2016 16:37
Decreased, Lymphocytes leads to Suppression, Immune system December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 122 Activation, Glucocorticoid Receptor Activation, Glucocorticoid Receptor
2 KE 202 Inhibition, Nuclear factor kappa B (NF-kB) Inhibition, Nuclear factor kappa B (NF-kB)
3 KE 152 Suppression, Inflammatory cytokines Suppression, Inflammatory cytokines
4 KE 168 Decreased, Lymphocytes Decreased, Lymphocytes
5 KE 145 Induction, IKB inhibitory protein Induction, IKB inhibitory protein
6 KE 403 Suppression, Immune system Suppression, Immune system
7 AO 323 Increased, Disease susceptibility Increased, Disease susceptibility

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Activation, Glucocorticoid Receptor leads to Induction, IKB inhibitory protein adjacent
Induction, IKB inhibitory protein leads to Inhibition, Nuclear factor kappa B (NF-kB) adjacent
Inhibition, Nuclear factor kappa B (NF-kB) leads to Suppression, Inflammatory cytokines adjacent
Suppression, Inflammatory cytokines leads to Decreased, Lymphocytes adjacent
Decreased, Lymphocytes leads to Suppression, Immune system adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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