API

Aop: 14

AOP Title

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Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility

Short name:

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Glucocorticoid Receptor, Activation

Authors

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Carlie A. LaLone, University of Minnesota, Water Resources Center, lalone.carlie@epa.gov

Point of Contact

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Carlie LaLone

Contributors

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  • Carlie LaLone

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Activation, Glucocorticoid Receptor September 16, 2017 10:14
Inhibition, Nuclear factor kappa B (NF-kB) September 16, 2017 10:14
Suppression, Inflammatory cytokines December 03, 2016 16:37
Decreased, Lymphocytes December 03, 2016 16:37
Induction, IKB inhibitory protein September 16, 2017 10:14
Increased, Disease susceptibility December 03, 2016 16:33
Suppression, Immune system December 03, 2016 16:37
Activation, Glucocorticoid Receptor leads to Induction, IKB inhibitory protein December 03, 2016 16:37
Induction, IKB inhibitory protein leads to Inhibition, Nuclear factor kappa B (NF-kB) December 03, 2016 16:37
Inhibition, Nuclear factor kappa B (NF-kB) leads to Suppression, Inflammatory cytokines December 03, 2016 16:37
Suppression, Inflammatory cytokines leads to Decreased, Lymphocytes December 03, 2016 16:37
Decreased, Lymphocytes leads to Suppression, Immune system December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Activation, Glucocorticoid Receptor Activation, Glucocorticoid Receptor

Key Events

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Title Short name
Inhibition, Nuclear factor kappa B (NF-kB) Inhibition, Nuclear factor kappa B (NF-kB)
Suppression, Inflammatory cytokines Suppression, Inflammatory cytokines
Decreased, Lymphocytes Decreased, Lymphocytes
Induction, IKB inhibitory protein Induction, IKB inhibitory protein
Suppression, Immune system Suppression, Immune system

Adverse Outcome

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Title Short name
Increased, Disease susceptibility Increased, Disease susceptibility

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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