API

Event: 122

Key Event Title

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Activation, Glucocorticoid Receptor

Short name

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Activation, Glucocorticoid Receptor

Biological Context

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Level of Biological Organization
Molecular

Cell term

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Cell term
eukaryotic cell


Organ term

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Key Event Components

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Process Object Action
glucocorticoid receptor activity glucocorticoid receptor increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Glucocorticoid Receptor, Activation MolecularInitiatingEvent
Network of SSRIs KeyEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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Site of action: The molecular site of action is the glucocorticoid receptor (GR). The GR is a steroid receptor belonging to the nuclear receptor (NR) family of ligand-dependent transcription factors. In the absence of a ligand, the GR is transcriptionally inactive in the cytoplasm. Responses at the macromolecular level: Binding of a hormonal ligand enables GR to translocate into the nucleas where it binds to genomic GC-response elements (GRE) and regulates trascription of associated genes.


How It Is Measured or Detected

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Domain of Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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