API

Aop: 214

AOP Title

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Network of SSRIs (selective serotonin reuptake inhibitors)

Short name:

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Network of SSRIs

Authors

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Point of Contact

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Lyle Burgoon

Contributors

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  • Hsin-Yen Wu
  • Lyle Burgoon
  • Edward Perkins

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:36

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Revision dates for related pages

Page Revision Date/Time
Inhibit, serotonin transporter activity April 13, 2017 14:16
Decreased, serotonin transporter activity May 31, 2017 16:47
Decreased, extracellular sodium (Na+) April 13, 2017 14:18
Decreased, extracellular chloride (Cl-) April 13, 2017 14:19
Increased, extracellular serotonin May 31, 2017 16:48
Increased, intracellular sodium (Na+) April 13, 2017 14:21
Increased, intracellular chloride (Cl-) April 13, 2017 14:21
Decreased, intracellular serotonin May 31, 2017 16:47
Decreased, packaged serotonin May 31, 2017 16:46
Decreased, synaptic release May 31, 2017 16:46
Increased, 5-HT3 (5-hydroxytryptamine) June 01, 2017 14:48
Inactivated, 5-HTR (serotonin receptors) May 31, 2017 16:45
Reduce expression, BDNF (Brain-derived neurotrophic factor) May 31, 2017 16:40
Decreased, neuroplasticity May 31, 2017 16:45
Increase, cortisone April 13, 2017 15:14
Activation, Glucocorticoid Receptor September 16, 2017 10:14
Reduced, BDNF (Brain-derived neurotrophic factor) May 31, 2017 17:30
Activation, 5-HT2A (Serotonin 2A) April 13, 2017 15:25
Activate, PLC (Phospholipase C) April 13, 2017 15:26
Increase, inositol triphosphate April 13, 2017 15:27
Increase, intracellular calcium April 13, 2017 15:27
Activate, calmodulin April 13, 2017 15:28
Increase, myosin light chain phosphorylation April 13, 2017 15:29
Increase, vascular smooth muscle contraction April 13, 2017 15:30
Increased, seizure June 01, 2017 11:55
Increased, agitation June 01, 2017 11:35
Increased, depression June 01, 2017 16:06
Increase, hypertension April 13, 2017 15:30
Decreased, extracellular serotonin May 31, 2017 16:46
Decreased, serotonin transporter activity leads to Increased, intracellular sodium (Na+) April 14, 2017 14:44
Decreased, serotonin transporter activity leads to Increased, intracellular chloride (Cl-) April 14, 2017 14:45
Decreased, serotonin transporter activity leads to Decreased, extracellular Na+ April 14, 2017 14:45
Decreased, serotonin transporter activity leads to Decreased, extracellular chloride (Cl-) April 14, 2017 14:46
Decreased, serotonin transporter activity leads to Increased, extracellular serotonin April 14, 2017 14:46
Decreased, serotonin transporter activity leads to Decreased, intracellular serotonin April 14, 2017 14:47
Decreased, intracellular serotonin leads to Decreased, packaged serotonin April 14, 2017 14:47
Decreased, packaged serotonin leads to Decreased, synaptic release April 14, 2017 14:47
Decreased, synaptic release leads to Decreased, extracellular serotonin April 14, 2017 14:48
Decreased, extracellular serotonin leads to Increased, 5-HT3 April 14, 2017 14:49
Decreased, extracellular serotonin leads to Inactivated, 5-HTR April 14, 2017 14:49
Decreased, extracellular serotonin leads to Activation, 5-HT2A April 14, 2017 14:49
Activation, 5-HT2A leads to Activate, PLC April 14, 2017 14:50
Activate, PLC leads to Increase, inositol triphosphate April 14, 2017 14:50
Increase, inositol triphosphate leads to Increase, intracellular calcium April 14, 2017 14:50
Increase, intracellular calcium leads to Activate, calmodulin April 14, 2017 14:51
Activate, calmodulin leads to Increase, myosin light chain phosphorylation April 14, 2017 14:51
Increase, myosin light chain phosphorylation leads to Increase, vascular smooth muscle contraction April 14, 2017 14:51
Increase, vascular smooth muscle contraction leads to Increase, hypertension April 14, 2017 14:52
Increased, 5-HT3 leads to Increased, seizure April 14, 2017 14:52
Inactivated, 5-HTR leads to Reduce expression, BDNF April 14, 2017 14:53
Reduce expression, BDNF leads to Decreased, neuroplasticity April 14, 2017 14:53
Decreased, neuroplasticity leads to Increased, agitation April 14, 2017 14:54
Decreased, neuroplasticity leads to Increased, depression April 14, 2017 14:54
Increase, cortisone leads to Activation, Glucocorticoid Receptor April 14, 2017 14:55
Activation, Glucocorticoid Receptor leads to Reduced, BDNF April 14, 2017 14:55
SSRI (Selective serotonin reuptake inhibitor) April 13, 2017 15:32
Increase cortisone levels (induced by stress) June 01, 2017 11:16

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Key Events

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Title Short name
Inhibit, serotonin transporter activity Inhibit, serotonin transporter activity
Decreased, serotonin transporter activity Decreased, serotonin transporter activity
Decreased, extracellular sodium (Na+) Decreased, extracellular Na+
Decreased, extracellular chloride (Cl-) Decreased, extracellular chloride (Cl-)
Increased, extracellular serotonin Increased, extracellular serotonin
Decreased, extracellular serotonin Decreased, extracellular serotonin
Increased, intracellular sodium (Na+) Increased, intracellular sodium (Na+)
Increased, intracellular chloride (Cl-) Increased, intracellular chloride (Cl-)
Decreased, intracellular serotonin Decreased, intracellular serotonin
Decreased, packaged serotonin Decreased, packaged serotonin
Decreased, synaptic release Decreased, synaptic release
Increased, 5-HT3 (5-hydroxytryptamine) Increased, 5-HT3
Inactivated, 5-HTR (serotonin receptors) Inactivated, 5-HTR
Reduce expression, BDNF (Brain-derived neurotrophic factor) Reduce expression, BDNF
Decreased, neuroplasticity Decreased, neuroplasticity
Increase, cortisone Increase, cortisone
Activation, Glucocorticoid Receptor Activation, Glucocorticoid Receptor
Reduced, BDNF (Brain-derived neurotrophic factor) Reduced, BDNF
Activation, 5-HT2A (Serotonin 2A) Activation, 5-HT2A
Activate, PLC (Phospholipase C) Activate, PLC
Increase, inositol triphosphate Increase, inositol triphosphate
Increase, intracellular calcium Increase, intracellular calcium
Activate, calmodulin Activate, calmodulin
Increase, myosin light chain phosphorylation Increase, myosin light chain phosphorylation
Increase, vascular smooth muscle contraction Increase, vascular smooth muscle contraction

Adverse Outcome

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Title Short name
Increased, seizure Increased, seizure
Increased, agitation Increased, agitation
Increased, depression Increased, depression
Increase, hypertension Increase, hypertension

Relationships Between Two Key Events (Including MIEs and AOs)

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Title Directness Evidence Quantitative Understanding
Decreased, serotonin transporter activity leads to Increased, intracellular sodium (Na+) Directly leads to
Decreased, serotonin transporter activity leads to Increased, intracellular chloride (Cl-) Directly leads to
Decreased, serotonin transporter activity leads to Decreased, extracellular Na+ Directly leads to
Decreased, serotonin transporter activity leads to Decreased, extracellular chloride (Cl-) Directly leads to
Decreased, serotonin transporter activity leads to Increased, extracellular serotonin Directly leads to
Decreased, serotonin transporter activity leads to Decreased, intracellular serotonin Directly leads to
Decreased, intracellular serotonin leads to Decreased, packaged serotonin Directly leads to
Decreased, packaged serotonin leads to Decreased, synaptic release Directly leads to
Decreased, synaptic release leads to Decreased, extracellular serotonin Directly leads to
Decreased, extracellular serotonin leads to Increased, 5-HT3 Directly leads to
Decreased, extracellular serotonin leads to Inactivated, 5-HTR Directly leads to
Decreased, extracellular serotonin leads to Activation, 5-HT2A Directly leads to
Activation, 5-HT2A leads to Activate, PLC Directly leads to
Activate, PLC leads to Increase, inositol triphosphate Directly leads to
Increase, inositol triphosphate leads to Increase, intracellular calcium Directly leads to
Increase, intracellular calcium leads to Activate, calmodulin Directly leads to
Activate, calmodulin leads to Increase, myosin light chain phosphorylation Directly leads to
Increase, myosin light chain phosphorylation leads to Increase, vascular smooth muscle contraction Directly leads to
Increase, vascular smooth muscle contraction leads to Increase, hypertension Directly leads to
Increased, 5-HT3 leads to Increased, seizure Directly leads to
Inactivated, 5-HTR leads to Reduce expression, BDNF Directly leads to
Reduce expression, BDNF leads to Decreased, neuroplasticity Directly leads to
Decreased, neuroplasticity leads to Increased, agitation Directly leads to
Decreased, neuroplasticity leads to Increased, depression Directly leads to
Increase, cortisone leads to Activation, Glucocorticoid Receptor Directly leads to
Activation, Glucocorticoid Receptor leads to Reduced, BDNF Directly leads to

Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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