API XML

Aop: 318

AOP Title

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Glucocorticoid Receptor activation leading to hepatic steatosis

Short name:

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GR activation leading to hepatic steatosis

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Chander K. Negi   (email point of contact)

Contributors

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  • Chander K. Negi

Status

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Author status OECD status OECD project SAAOP status
Under Development: Contributions and Comments Welcome


This AOP was last modified on May 17, 2020 18:15

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Revision dates for related pages

Page Revision Date/Time
Activation, Glucocorticoid Receptor July 07, 2020 12:19
Decreased, Mitochondrial Fatty Acid Beta Oxidation September 16, 2017 10:14
Increased, Liver Steatosis March 07, 2019 09:49
Decreased, PPAR-alpha activation September 16, 2017 10:14
Activation, Glucocorticoid Receptor leads to Decreased, Mitochondrial Fatty Acid Beta Oxidation February 22, 2020 10:11
Decreased, Mitochondrial Fatty Acid Beta Oxidation leads to Increased, Liver Steatosis February 22, 2020 10:12
Activation, Glucocorticoid Receptor leads to Decreased, PPAR-alpha activation February 22, 2020 10:31
Decreased, PPAR-alpha activation leads to Increased, Liver Steatosis February 22, 2020 10:32

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 122 Activation, Glucocorticoid Receptor Activation, Glucocorticoid Receptor
2 KE 860 Decreased, Mitochondrial Fatty Acid Beta Oxidation Decreased, Mitochondrial Fatty Acid Beta Oxidation
3 KE 231 Decreased, PPAR-alpha activation Decreased, PPAR-alpha activation
4 AO 459 Increased, Liver Steatosis Increased, Liver Steatosis

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Activation, Glucocorticoid Receptor leads to Decreased, Mitochondrial Fatty Acid Beta Oxidation adjacent Moderate Not Specified
Decreased, Mitochondrial Fatty Acid Beta Oxidation leads to Increased, Liver Steatosis adjacent High Moderate
Activation, Glucocorticoid Receptor leads to Decreased, PPAR-alpha activation adjacent Moderate Not Specified
Decreased, PPAR-alpha activation leads to Increased, Liver Steatosis adjacent High Moderate

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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