API

Event: 459

Key Event Title

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Increased, Liver Steatosis

Short name

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Increased, Liver Steatosis

Biological Context

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Level of Biological Organization
Organ


Organ term

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Organ term
liver


Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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Stressors

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Vertebrates Vertebrates High NCBI

Life Stages

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Life stage Evidence
All life stages High

Sex Applicability

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Term Evidence
Unspecific High

Key Event Description

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Biological state: liver steatosis is the inappropriate storage of fat in hepatocytes.

Biological compartment: steatosis is generally an organ-level diagnosis; however, the pathology occurs within the hepatocytes.

Role in biology: steatosis is an adverse endpoint. 


How It Is Measured or Detected

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Steatosis is measured by lipidomics approaches that measure lipid levels, or by histology.


Domain of Applicability

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Steatosis is the result of perturbations in well-known metabolic pathways that are well-studied and well-known in many taxa.


Regulatory Significance of the Adverse Outcome

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Steatosis is a regulatory endpoint and has been used as an endpoint in many US EPA assessments, including IRIS assessments.


References

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