API

Aop: 232

AOP Title

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NFE2/Nrf2 repression to steatosis

Short name:

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NFE2/Nrf2 repression to steatosis

Authors

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Point of Contact

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Lyle Burgoon

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon
  • Erik Mylroie

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:27

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Revision dates for related pages

Page Revision Date/Time
NFE2/Nrf2 repression June 02, 2017 16:27
Increased, steatosis June 02, 2017 16:28
Reduced, FXR activity June 02, 2017 16:29
Reduced, SHP activity June 02, 2017 16:30
Activated, LXR June 02, 2017 16:31
Reduced, PPARalpha June 02, 2017 16:32
Reduced, HSD17B4 activity June 02, 2017 16:32
Reduced, fatty acid beta oxidation June 02, 2017 16:35
NFE2/Nrf2 repression leads to Reduced, FXR activity June 02, 2017 16:35
Reduced, FXR activity leads to Reduced, SHP activity June 02, 2017 16:36
Reduced, SHP activity leads to Activated, LXR June 02, 2017 16:36
Activated, LXR leads to Reduced, PPARalpha June 02, 2017 16:36
Reduced, PPARalpha leads to Reduced, HSD17B4 activity June 02, 2017 16:36
Reduced, HSD17B4 activity leads to Reduced, fatty acid beta oxidation June 02, 2017 16:37
Reduced, fatty acid beta oxidation leads to Increased, steatosis June 02, 2017 16:37
NFE2/Nrf2 repression June 02, 2017 16:27

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Name Evidence Term
NFE2/Nrf2 repression

Molecular Initiating Event

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Title Short name
NFE2/Nrf2 repression NFE2/Nrf2 repression

Key Events

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Title Short name
Reduced, FXR activity Reduced, FXR activity
Reduced, SHP activity Reduced, SHP activity
Activated, LXR Activated, LXR
Reduced, PPARalpha Reduced, PPARalpha
Reduced, HSD17B4 activity Reduced, HSD17B4 activity
Reduced, fatty acid beta oxidation Reduced, fatty acid beta oxidation

Adverse Outcome

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Title Short name
Increased, steatosis Increased, steatosis

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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