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Aop: 232

AOP Title

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NFE2/Nrf2 repression to steatosis

Short name:

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NFE2/Nrf2 repression to steatosis

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Lyle Burgoon   (email point of contact)

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon
  • Erik Mylroie

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:27

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Revision dates for related pages

Page Revision Date/Time
NFE2/Nrf2 repression June 02, 2017 16:27
Increased, steatosis June 02, 2017 16:28
Reduced, FXR activity June 02, 2017 16:29
Reduced, SHP activity June 02, 2017 16:30
Activated, LXR June 02, 2017 16:31
Reduced, PPARalpha June 02, 2017 16:32
Reduced, HSD17B4 activity June 02, 2017 16:32
Reduced, fatty acid beta oxidation June 02, 2017 16:35
NFE2/Nrf2 repression leads to Reduced, FXR activity June 02, 2017 16:35
Reduced, FXR activity leads to Reduced, SHP activity June 02, 2017 16:36
Reduced, SHP activity leads to Activated, LXR June 02, 2017 16:36
Activated, LXR leads to Reduced, PPARalpha June 02, 2017 16:36
Reduced, PPARalpha leads to Reduced, HSD17B4 activity June 02, 2017 16:36
Reduced, HSD17B4 activity leads to Reduced, fatty acid beta oxidation June 02, 2017 16:37
Reduced, fatty acid beta oxidation leads to Increased, steatosis June 02, 2017 16:37
NFE2/Nrf2 repression June 02, 2017 16:27

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 1417 NFE2/Nrf2 repression NFE2/Nrf2 repression
2 KE 1419 Reduced, FXR activity Reduced, FXR activity
3 KE 1420 Reduced, SHP activity Reduced, SHP activity
4 KE 1421 Activated, LXR Activated, LXR
5 KE 1422 Reduced, PPARalpha Reduced, PPARalpha
6 KE 1423 Reduced, HSD17B4 activity Reduced, HSD17B4 activity
7 KE 1424 Reduced, fatty acid beta oxidation Reduced, fatty acid beta oxidation
8 AO 1418 Increased, steatosis Increased, steatosis

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
NFE2/Nrf2 repression leads to Reduced, FXR activity adjacent
Reduced, FXR activity leads to Reduced, SHP activity adjacent
Reduced, SHP activity leads to Activated, LXR adjacent
Activated, LXR leads to Reduced, PPARalpha adjacent
Reduced, PPARalpha leads to Reduced, HSD17B4 activity adjacent
Reduced, HSD17B4 activity leads to Reduced, fatty acid beta oxidation adjacent
Reduced, fatty acid beta oxidation leads to Increased, steatosis adjacent

Network View

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Stressors

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Name Evidence Term
NFE2/Nrf2 repression

Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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