API XML

Aop: 62

AOP Title

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AKT2 activation leading to hepatic steatosis

Short name:

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AKT2 activation to steatosis

Graphical Representation

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Click to download graphical representation template

Authors

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Michelle Angrish, Brian Chorley, U.S. EPA

Point of Contact

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Michelle Angrish   (email point of contact)

Contributors

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  • Brian Chorley
  • Michelle Angrish
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Activation, AKT2 September 16, 2017 10:15
Increased, Liver Steatosis November 27, 2017 12:48
systemic inflammation leading to hepatic steatosis February 24, 2017 19:47
Activation, SREBF1 September 16, 2017 10:15
inflammation leads to Activation, AKT2 December 03, 2016 16:37
Activation, AKT2 leads to Activation, SREBF1 August 31, 2017 10:52
Activation, SREBF1 leads to Increased, Liver Steatosis August 31, 2017 10:53

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 486 systemic inflammation leading to hepatic steatosis inflammation
2 KE 484 Activation, AKT2 Activation, AKT2
3 KE 457 Activation, SREBF1 Activation, SREBF1
4 AO 459 Increased, Liver Steatosis Increased, Liver Steatosis

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
inflammation leads to Activation, AKT2 non-adjacent
Activation, AKT2 leads to Activation, SREBF1 non-adjacent
Activation, SREBF1 leads to Increased, Liver Steatosis non-adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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