API

Aop: 62

AOP Title

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AKT2 activation leading to hepatic steatosis

Short name:

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AKT2 activation to steatosis

Authors

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Michelle Angrish, Brian Chorley, U.S. EPA

Point of Contact

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Michelle Angrish

Contributors

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  • Brian Chorley
  • Michelle Angrish
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on February 26, 2017 20:13

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Revision dates for related pages

Page Revision Date/Time
Activation, AKT2 September 16, 2017 10:15
Increased, Liver Steatosis September 16, 2017 10:14
systemic inflammation leading to hepatic steatosis February 24, 2017 19:47
Activation, SREBF1 September 16, 2017 10:15
inflammation leads to Activation, AKT2 December 03, 2016 16:37
Activation, AKT2 leads to Activation, SREBF1 August 31, 2017 10:52
Activation, SREBF1 leads to Increased, Liver Steatosis August 31, 2017 10:53

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Key Events

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Title Short name
Activation, AKT2 Activation, AKT2
Activation, SREBF1 Activation, SREBF1

Adverse Outcome

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Title Short name
Increased, Liver Steatosis Increased, Liver Steatosis

Relationships Between Two Key Events (Including MIEs and AOs)

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Title Directness Evidence Quantitative Understanding
inflammation leads to Activation, AKT2 Indirectly leads to
Activation, AKT2 leads to Activation, SREBF1 Indirectly leads to
Activation, SREBF1 leads to Increased, Liver Steatosis Indirectly leads to

Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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