API

Event: 486

Key Event Title

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systemic inflammation leading to hepatic steatosis

Short name

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inflammation

Key Event Component

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Process Object Action
inflammatory response occurrence

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
AKT2 activation leading to hepatic steatosis MolecularInitiatingEvent

Stressors

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Level of Biological Organization

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Biological Organization
Organ


Organ term

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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How This Key Event Works

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Systemic inflammation causes release of inflammatory mediators into the circulation that have autocrine and paracrine effects. 


How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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