API

Event: 457

Key Event Title

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Activation, SREBF1

Short name

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Activation, SREBF1

Biological Context

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Level of Biological Organization
Molecular

Cell term

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Cell term
hepatocyte


Organ term

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Key Event Components

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Process Object Action
signaling sterol regulatory element-binding protein 1 increased
SREBP signaling pathway sterol regulatory element-binding protein 1 increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
NR1I3 suppression to steatosis KeyEvent
AKT2 activation to steatosis KeyEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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How It Is Measured or Detected

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Domain of Applicability

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References

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