API XML

Aop: 60

AOP Title

?


NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis

Short name:

?

PXR activation to steatosis

Graphical Representation

?

Click to download graphical representation template

Authors

?


Michelle Angrish and Brian Chorley

Point of Contact

?


Michelle Angrish   (email point of contact)

Contributors

?


  • Brian Chorley
  • Michelle Angrish
  • Lyle Burgoon

Status

?

Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

?

Revision dates for related pages

Page Revision Date/Time
Activation, PXR/SXR September 16, 2017 10:14
Increased, Liver Steatosis November 27, 2017 12:48
Inhibition, FoxA2 September 16, 2017 10:15
Decreased, Mitochondrial fatty acid beta-oxidation September 16, 2017 10:14
Down Regulation, CPT1A September 16, 2017 10:15
Down Regulation, HMGCS2 September 16, 2017 10:15
Up Regulation, SCD-1 September 16, 2017 10:15
Up Regulation, CD36 September 16, 2017 10:14
Increased, FA Influx September 16, 2017 10:15
Decreased, Ketogenesis September 16, 2017 10:15
Increased, Triglyceride formation September 16, 2017 10:15
Accumulation, Fatty acid September 16, 2017 10:14
Up Regulation, CD36 leads to Increased, FA Influx December 03, 2016 16:37
Down Regulation, HMGCS2 leads to Decreased, Ketogenesis December 03, 2016 16:37
Activation, PXR/SXR leads to Inhibition, FoxA2 December 03, 2016 16:37
Down Regulation, CPT1A leads to Decreased, Mitochondrial fatty acid beta-oxidation December 03, 2016 16:37
Activation, PXR/SXR leads to Up Regulation, CD36 December 03, 2016 16:37
Activation, PXR/SXR leads to Up Regulation, SCD-1 December 03, 2016 16:37
Inhibition, FoxA2 leads to Down Regulation, HMGCS2 December 03, 2016 16:37
Inhibition, FoxA2 leads to Down Regulation, CPT1A December 03, 2016 16:37
Up Regulation, SCD-1 leads to Increased, Triglyceride formation December 03, 2016 16:37
Increased, Triglyceride formation leads to Increased, Liver Steatosis December 03, 2016 16:37
Increased, FA Influx leads to Increased, Triglyceride formation August 31, 2017 09:39
Increased, FA Influx leads to Accumulation, Fatty acid December 03, 2016 16:37
Decreased, Mitochondrial fatty acid beta-oxidation leads to Accumulation, Fatty acid December 03, 2016 16:37
Decreased, Ketogenesis leads to Accumulation, Fatty acid August 31, 2017 10:45
Accumulation, Fatty acid leads to Increased, Liver Steatosis December 03, 2016 16:37

Abstract

?



Background (optional)

?



Summary of the AOP

?


Events: Molecular Initiating Events (MIE)

?

Key Events (KE)

?

Adverse Outcomes (AO)

?

Sequence Type Event ID Title Short name
1 MIE 245 Activation, PXR/SXR Activation, PXR/SXR
2 KE 471 Inhibition, FoxA2 Inhibition, FoxA2
3 KE 179 Decreased, Mitochondrial fatty acid beta-oxidation Decreased, Mitochondrial fatty acid beta-oxidation
4 KE 472 Down Regulation, CPT1A Down Regulation, CPT1A
5 KE 474 Down Regulation, HMGCS2 Down Regulation, HMGCS2
6 KE 462 Up Regulation, SCD-1 Up Regulation, SCD-1
7 KE 54 Up Regulation, CD36 Up Regulation, CD36
8 KE 465 Increased, FA Influx Increased, FA Influx
9 KE 477 Decreased, Ketogenesis Decreased, Ketogenesis
10 KE 454 Increased, Triglyceride formation Increased, Triglyceride formation
11 KE 327 Accumulation, Fatty acid Accumulation, Fatty acid
12 AO 459 Increased, Liver Steatosis Increased, Liver Steatosis

Relationships Between Two Key Events
(Including MIEs and AOs)

?

Title Adjacency Evidence Quantitative Understanding
Up Regulation, CD36 leads to Increased, FA Influx adjacent High
Down Regulation, HMGCS2 leads to Decreased, Ketogenesis adjacent High
Activation, PXR/SXR leads to Inhibition, FoxA2 adjacent High
Down Regulation, CPT1A leads to Decreased, Mitochondrial fatty acid beta-oxidation adjacent High
Activation, PXR/SXR leads to Up Regulation, CD36 adjacent Low
Activation, PXR/SXR leads to Up Regulation, SCD-1 adjacent Low
Inhibition, FoxA2 leads to Down Regulation, HMGCS2 adjacent High
Inhibition, FoxA2 leads to Down Regulation, CPT1A adjacent High
Up Regulation, SCD-1 leads to Increased, Triglyceride formation adjacent High
Increased, Triglyceride formation leads to Increased, Liver Steatosis adjacent High
Increased, FA Influx leads to Increased, Triglyceride formation adjacent High
Increased, FA Influx leads to Accumulation, Fatty acid adjacent High
Decreased, Mitochondrial fatty acid beta-oxidation leads to Accumulation, Fatty acid adjacent High
Accumulation, Fatty acid leads to Increased, Liver Steatosis adjacent High
Decreased, Ketogenesis leads to Accumulation, Fatty acid non-adjacent Moderate

Network View

?

 

Stressors

?

Life Stage Applicability

?

Taxonomic Applicability

?

Sex Applicability

?

Overall Assessment of the AOP

?



Domain of Applicability

?


Essentiality of the Key Events

?


Evidence Assessment

?


Quantitative Understanding

?


Considerations for Potential Applications of the AOP (optional)

?



References

?