API

Aop: 60

AOP Title

?


NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis

Short name:

?

PXR activation to steatosis

Authors

?


Michelle Angrish and Brian Chorley

Point of Contact

?


Michelle Angrish

Contributors

?


  • Brian Chorley
  • Michelle Angrish
  • Lyle Burgoon

Status

?

Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on February 26, 2017 20:11

?

Revision dates for related pages

Page Revision Date/Time
Activation, PXR/SXR September 16, 2017 10:14
Increased, Liver Steatosis September 16, 2017 10:14
Inhibition, FoxA2 September 16, 2017 10:15
Decreased, Mitochondrial fatty acid beta-oxidation September 16, 2017 10:14
Down Regulation, CPT1A September 16, 2017 10:15
Down Regulation, HMGCS2 September 16, 2017 10:15
Up Regulation, SCD-1 September 16, 2017 10:15
Up Regulation, CD36 September 16, 2017 10:14
Increased, FA Influx September 16, 2017 10:15
Decreased, Ketogenesis September 16, 2017 10:15
Increased, Triglyceride formation September 16, 2017 10:15
Accumulation, Fatty acid September 16, 2017 10:14
Up Regulation, CD36 leads to Increased, FA Influx December 03, 2016 16:37
Down Regulation, HMGCS2 leads to Decreased, Ketogenesis December 03, 2016 16:37
Activation, PXR/SXR leads to Inhibition, FoxA2 December 03, 2016 16:37
Down Regulation, CPT1A leads to Decreased, Mitochondrial fatty acid beta-oxidation December 03, 2016 16:37
Activation, PXR/SXR leads to Up Regulation, CD36 December 03, 2016 16:37
Activation, PXR/SXR leads to Up Regulation, SCD-1 December 03, 2016 16:37
Inhibition, FoxA2 leads to Down Regulation, HMGCS2 December 03, 2016 16:37
Inhibition, FoxA2 leads to Down Regulation, CPT1A December 03, 2016 16:37
Up Regulation, SCD-1 leads to Increased, Triglyceride formation December 03, 2016 16:37
Increased, Triglyceride formation leads to Increased, Liver Steatosis December 03, 2016 16:37
Increased, FA Influx leads to Increased, Triglyceride formation August 31, 2017 09:39
Increased, FA Influx leads to Accumulation, Fatty acid December 03, 2016 16:37
Decreased, Mitochondrial fatty acid beta-oxidation leads to Accumulation, Fatty acid December 03, 2016 16:37
Decreased, Ketogenesis leads to Accumulation, Fatty acid August 31, 2017 10:45
Accumulation, Fatty acid leads to Increased, Liver Steatosis December 03, 2016 16:37

Abstract

?



Background (optional)

?



Summary of the AOP

?



Stressors

?


Molecular Initiating Event

?

Title Short name
Activation, PXR/SXR Activation, PXR/SXR

Key Events

?

Title Short name
Inhibition, FoxA2 Inhibition, FoxA2
Decreased, Mitochondrial fatty acid beta-oxidation Decreased, Mitochondrial fatty acid beta-oxidation
Down Regulation, CPT1A Down Regulation, CPT1A
Down Regulation, HMGCS2 Down Regulation, HMGCS2
Up Regulation, SCD-1 Up Regulation, SCD-1
Up Regulation, CD36 Up Regulation, CD36
Increased, FA Influx Increased, FA Influx
Decreased, Ketogenesis Decreased, Ketogenesis
Increased, Triglyceride formation Increased, Triglyceride formation
Accumulation, Fatty acid Accumulation, Fatty acid

Adverse Outcome

?

Title Short name
Increased, Liver Steatosis Increased, Liver Steatosis

Relationships Between Two Key Events (Including MIEs and AOs)

?

Network View

?

 

Life Stage Applicability

?


Taxonomic Applicability

?


Sex Applicability

?


Graphical Representation

?

Click to download graphical representation template

Overall Assessment of the AOP

?



Domain of Applicability

?


Essentiality of the Key Events

?


Weight of Evidence Summary

?


Quantitative Considerations

?


Considerations for Potential Applications of the AOP (optional)

?



References

?