API

Event: 179

Key Event Title

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Decreased, Mitochondrial fatty acid beta-oxidation

Short name

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Decreased, Mitochondrial fatty acid beta-oxidation

Key Event Component

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Process Object Action
fatty acid beta-oxidation fatty acid decreased

Key Event Overview


AOPs Including This Key Event

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Stressors

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Level of Biological Organization

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Biological Organization
Molecular

Cell term

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Cell term
hepatocyte


Organ term

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Homo sapiens Homo sapiens Strong NCBI

Life Stages

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Sex Applicability

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How This Key Event Works

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Fatty acid oxidation in liver tissue is controlled by PPARalpha signaling networks (Evans et al 2004). The PPARalpha signaling network controls expression of the genes within metabolic pathways that catalyze fatty acid oxidation reactions (Desvergne and Wahli 1999).


How It Is Measured or Detected

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A variety of approaches establishing the effects of PPARalpha signaling on fatty acid oxidation are reviewed in Evans et al (2004).


Evidence Supporting Taxonomic Applicability

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See review for Human PPARalpha signaling in (Evans et al 2004).


References

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Desvergne B, Wahli W (1999) Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocrine Reviews 20(5): 649-688.

Evans RM, Barish GD, Wang YX: PPARs and the complex journey to obesity. Nat Med 2004, 10(4):355-361.