API XML

Aop: 28

AOP Title

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Cyclooxygenase inhibition leading reproductive failure

Short name:

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Cyclooxygenase inhibition leading reproductive failure

Graphical Representation

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Click to download graphical representation template

Authors

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Dan Villeneuve, US EPA Mid-Continent Ecology Division (villeneuve.dan@epa.gov)

Point of Contact

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Dan Villeneuve   (email point of contact)

Contributors

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  • Dan Villeneuve

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Inhibition, Cyclooxygenase activity September 16, 2017 10:14
Reduction, Prostaglandin E2 concentration September 16, 2017 10:14
Reduction, Ca and HCO3 transport to shell gland September 16, 2017 10:14
Reduction, Eggshell thickness September 16, 2017 10:14
N/A, Gap September 16, 2017 10:14
N/A, Reproductive failure December 03, 2016 16:37
Inhibition, Cyclooxygenase activity leads to Reduction, Prostaglandin E2 concentration December 03, 2016 16:37
Reduction, Prostaglandin E2 concentration leads to N/A, Gap December 03, 2016 16:37
N/A, Gap leads to Reduction, Ca and HCO3 transport to shell gland December 03, 2016 16:37
Reduction, Ca and HCO3 transport to shell gland leads to Reduction, Eggshell thickness December 03, 2016 16:37
Reduction, Eggshell thickness leads to N/A, Reproductive failure December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 79 Inhibition, Cyclooxygenase activity Inhibition, Cyclooxygenase activity
2 KE 243 Reduction, Prostaglandin E2 concentration Reduction, Prostaglandin E2 concentration
3 KE 49 Reduction, Ca and HCO3 transport to shell gland Reduction, Ca and HCO3 transport to shell gland
4 KE 106 Reduction, Eggshell thickness Reduction, Eggshell thickness
5 KE 119 N/A, Gap N/A, Gap
6 AO 253 N/A, Reproductive failure N/A, Reproductive failure

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Inhibition, Cyclooxygenase activity leads to Reduction, Prostaglandin E2 concentration adjacent Moderate
Reduction, Prostaglandin E2 concentration leads to N/A, Gap adjacent Not Specified
N/A, Gap leads to Reduction, Ca and HCO3 transport to shell gland adjacent Not Specified
Reduction, Ca and HCO3 transport to shell gland leads to Reduction, Eggshell thickness adjacent Moderate
Reduction, Eggshell thickness leads to N/A, Reproductive failure adjacent High

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Consider the following criteria (may include references to KE Relationship pages): 1. concordance of dose-response relationships; 2. temporal concordance among the key events and adverse effect; 3. strength, consistency, and specificity of association of adverse effect and initiating event; 4. biological plausibility, coherence, and consistency of the experimental evidence; 5. alternative mechanisms that logically present themselves and the extent to which they may distract from the postulated AOP. It should be noted that alternative mechanisms of action, if supported, require a separate AOP; 6. uncertainties, inconsistencies and data gaps.

Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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