API

Aop: 28

AOP Title

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Cyclooxygenase inhibition leading reproductive failure

Short name:

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Cyclooxygenase inhibition leading reproductive failure

Authors

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Dan Villeneuve, US EPA Mid-Continent Ecology Division (villeneuve.dan@epa.gov)

Point of Contact

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Dan Villeneuve

Contributors

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  • Dan Villeneuve

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Inhibition, Cyclooxygenase activity September 16, 2017 10:14
Reduction, Prostaglandin E2 concentration September 16, 2017 10:14
Reduction, Ca and HCO3 transport to shell gland September 16, 2017 10:14
Reduction, Eggshell thickness September 16, 2017 10:14
N/A, Gap September 16, 2017 10:14
N/A, Reproductive failure December 03, 2016 16:37
Inhibition, Cyclooxygenase activity leads to Reduction, Prostaglandin E2 concentration December 03, 2016 16:37
Reduction, Prostaglandin E2 concentration leads to N/A, Gap December 03, 2016 16:37
N/A, Gap leads to Reduction, Ca and HCO3 transport to shell gland December 03, 2016 16:37
Reduction, Ca and HCO3 transport to shell gland leads to Reduction, Eggshell thickness December 03, 2016 16:37
Reduction, Eggshell thickness leads to N/A, Reproductive failure December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Inhibition, Cyclooxygenase activity Inhibition, Cyclooxygenase activity

Key Events

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Title Short name
Reduction, Prostaglandin E2 concentration Reduction, Prostaglandin E2 concentration
Reduction, Ca and HCO3 transport to shell gland Reduction, Ca and HCO3 transport to shell gland
Reduction, Eggshell thickness Reduction, Eggshell thickness
N/A, Gap N/A, Gap

Adverse Outcome

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Title Short name
N/A, Reproductive failure N/A, Reproductive failure

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Consider the following criteria (may include references to KE Relationship pages): 1. concordance of dose-response relationships; 2. temporal concordance among the key events and adverse effect; 3. strength, consistency, and specificity of association of adverse effect and initiating event; 4. biological plausibility, coherence, and consistency of the experimental evidence; 5. alternative mechanisms that logically present themselves and the extent to which they may distract from the postulated AOP. It should be noted that alternative mechanisms of action, if supported, require a separate AOP; 6. uncertainties, inconsistencies and data gaps.

Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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