API

Event: 213

Key Event Title

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N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)

Short name

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N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin

Biological Context

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Level of Biological Organization
Molecular

Cell term

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Organ term

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Key Event Components

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Process Object Action
heme oxidation increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Hemoglobin oxidation leading to hematotoxicity MolecularInitiatingEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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How It Is Measured or Detected

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Domain of Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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