AOPs With OECD Status

TFHA/WNT Endorsed

Open for citation & comment

Title Point of Contact MIE AO OECD Project
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk DNA alkylation heritable mutations 1.11
Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve Aromatate Inhib reproductive dysfunction 1.12
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price Glutamate Receptor learning and memory impairment. 1.23
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price NMDAR impairment of learning and memory abilities 1.22
Covalent Protein binding leading to Skin Sensitisation Brigitte Landesmann 1.1
Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann Protein alkylation liver fibrosis 1.14

EAGMST Approved

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Title Point of Contact MIE AO OECD Project
Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve AR reproductive dysfunction 1.12
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet NMDAR neuroinflammation and lead to neurodegeneration 1.13
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor Motor function, impaired 1.33
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton TPO neurodevelopmental outcomes 1.10

EAGMST Under Review

Open for citation & comment

Title Point of Contact MIE AO OECD Project
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon AFB1 hepatocellular carcinoma 1.8
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard PPAR impaired fertility 1.21
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Richard C. Peffer, Ph.D., DABT CAR hepatocellular adenomas and carcinomas 1.18
Cyp2E1 Activation Leading to Liver Cancer Carole Yauk 1.24
Disruption of VEGFR Signaling Leading to Developmental Defects Tom Knudsen VEGF developmental outcomes 1.6
Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve ER reproductive dysfunction 1.12
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Justin Teeguarden unclear contact nasal tumors 2.7
PPARα activation in utero leading to impaired fertility in males Elise Grignard PPAR impaired fertility 1.21
Sustained AhR Activation leading to Rodent Liver Tumours Rick Becker AhR liver tumors 1.7

Open for comment. Do not cite

Under Development

Under development: Not open for comment. Do not cite

Title Point of Contact MIE AO OECD Project
Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve AChE acute mortality 1.3
AhR signalling leading to placental vascular disruption Sabrina Tait 1.42
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood AR adenomas and carcinomas 1.26
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Barnett Rattner 1.31
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich multiple neuroinflammation leading to neurodegeneration 1.13
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken ABCB11 cholestatic liver injury 1.19
Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen 1.35
Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen 1.35
Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen 1.35
Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen 1.35
EGFR Activation Leading to Decreased Lung Function Karsta Luettich EGFR 1.51
Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic Liver, Inflammation 1.47
Histone deacetylase inhibition leading to testicular toxicity Takashi Yamada 1.52
Increased substance interaction with the resident cell membrane components leading to lung fibrosis Sabina Halappanavar 1.32
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Erik Janus 1.41
Kidney dysfunction by decreased thyroid hormone Seokjoo Yoon unclear - KE as MIE? kidnney dysfunction 1.40
Narcosis leading to respiratory failure Dries Knapen undefined sensitisation of the respiratory tract 1.2
Oxidation of iron in hemoglobin leading to hematotoxicity Mitchell S. Wilbanks heme oxidation ? hematotoxicity 1.16
Peptide Oxidation Leading to Hypertension Frazer Lowe 1.50
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno case study 2.5
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi 1.54
Phospholipase A inhibitors lead to hepatotoxicity Seokjoo Yoon phospolipase A hepatotoxicity 1.39
PPARalpha-dependent liver cancer Chris Corton PPAR alpha liver cancer 1.17
PPARα activation leading to impaired fertility in adult male rodents Elise Grignard PPAR α impaired fertility 1.21
Sensitisation of the Respiratory Tract induced by Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins Kristie Sullivan unclear what proteins sensitisation of the respiratory tract 1.20
Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen 1.35
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman mulitple neurodevelopmental outcomes 1.9