AOPs With OECD Status

TFHA/WNT Endorsed

Open for citation & comment

Title Point of Contact MIE AO OECD Project
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk DNA alkylation heritable mutations 1.11
Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve AR reproductive dysfunction 1.12
Antagonist binding to PPARα leading to body-weight loss Kurt A. Gust PPAR starvation-like body-weight loss 2.3
Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve Aromatate Inhib reproductive dysfunction 1.12
Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker AhR embryo toxicity 1.27
Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat Activation, AhR Increase, Early Life Stage Mortality 1.7
Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat AhR uroporphyria 1.7
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price Glutamate Receptor learning and memory impairment. 1.23
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Ping Gong GABA epileptic seizures 1.15
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price NMDAR impairment of learning and memory abilities 1.22
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet NMDAR neuroinflammation and lead to neurodegeneration 1.13
Covalent Protein binding leading to Skin Sensitisation Sharon Munn Covalent Binding, Protein sensitisation, skin 1.1
Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price NIS learning and memory deficits in children 1.28
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor Motor function, impaired 1.33
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton TPO neurodevelopmental outcomes 1.10
Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann Protein alkylation liver fibrosis 1.14

EAGMST Under Review

Open for citation & comment

Title Point of Contact MIE AO OECD Project
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon AFB1 hepatocellular carcinoma 1.8
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard PPAR impaired fertility 1.21
Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti tubulin? aneuploid offspring 1.11
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser CAR hepatocellular adenomas and carcinomas 1.17
Cyp2E1 Activation Leading to Liver Cancer Francina Webster Activation of Cyp2E1 liver cancer 1.24
Disruption of VEGFR Signaling Leading to Developmental Defects Tom Knudsen VEGF developmental outcomes 1.6
Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve ER reproductive dysfunction 1.12
Inhibition of IL-1 binding to IL-1 receptor leading to increased susceptibility to infection Yutaka Kimura 1.48
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Justin Teeguarden unclear contact nasal tumors 2.7
PPARα activation in utero leading to impaired fertility in males Elise Grignard PPAR impaired fertility 1.21
Sustained AhR Activation leading to Rodent Liver Tumours Rick Becker AhR liver tumors 1.7

Open for comment. Do not cite

Under development: Not open for comment. Do not cite

Under Development

Open for citation & comment

Open for comment. Do not cite

Title Point of Contact MIE AO OECD Project
Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park 1.59

Open for adoption

Not under active development

Under development: Not open for comment. Do not cite

Title Point of Contact MIE AO OECD Project
5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen 1.90
AhR activation leading to placental insufficiency Sabrina Tait 1.42
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen 1.90
Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Yasuharu Otsubo 1.73
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken ABCB11 cholestatic liver injury 1.19
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen 1.90
Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen 1.35
Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen 1.35
Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen 1.35
Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen 1.35
Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman 1.79
EGFR Activation Leading to Decreased Lung Function Karsta Luettich EGFR 1.51
Frustrated phagocytosis-induced lung cancer Carole Seidel 1.86
Increased DNA damage leading to increased risk of breast cancer Jessica Helm 1.80
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm 1.80
Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Yasuhiro Yoshida 1.74
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally 1.43
Kidney dysfunction by decreased thyroid hormone Jung-Hwa Oh unclear - KE as MIE? kidnney dysfunction 1.40
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci 1.45
L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci 1.45
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci 1.45
Lung surfactant function disruption leading to sudden adverse lung effects Jorid Birkelund Sørli 1.87
Narcosis leading to respiratory failure Dries Knapen undefined sensitisation of the respiratory tract 1.2
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi 1.54
PPARalpha-dependent liver cancer Chris Corton PPAR alpha liver cancer 1.17
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally 1.43
Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Sarah Søs Poulsen 1.55
Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Hiroyuki Komatsu 1.75
Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton Thyroid Receptor Antagonism Cognitve function, Decreased 1.84
Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen 1.35
Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada 1.60

Under Development: Contributions and Comments Welcome

Title Point of Contact MIE AO OECD Project
Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve AChE acute mortality 1.3
Chronic reactive oxygen species leading to human treatment-resistant gastric cancer Shihori Tanabe 1.58
Inhibition of retinaldehyde dehydrogenase leads to population decline Young Jun Kim 1.77
Phospholipase A inhibitors lead to hepatotoxicity Jung-Hwa Oh phospolipase A hepatotoxicity 1.39
Sensitisation of the Respiratory Tract induced by Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins Kristie Sullivan unclear what proteins sensitisation of the respiratory tract 1.20