AOPs With OECD Status

TFHA/WNT Endorsed

Open for citation & comment

Title Point of Contact MIE AO OECD Project
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk DNA alkylation heritable mutations 1.11
Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve AR reproductive dysfunction 1.12
Antagonist binding to PPARα leading to body-weight loss Kurt A. Gust PPAR starvation-like body-weight loss 2.3
Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve Aromatate Inhib reproductive dysfunction 1.12
Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker AhR embryo toxicity 1.27
Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat Activation, AhR Increase, Early Life Stage Mortality 1.7
Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat AhR uroporphyria 1.7
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price Glutamate Receptor learning and memory impairment. 1.23
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Ping Gong GABA epileptic seizures 1.15
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price NMDAR impairment of learning and memory abilities 1.22
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet NMDAR neuroinflammation and lead to neurodegeneration 1.13
Covalent Protein binding leading to Skin Sensitisation Sharon Munn Covalent Binding, Protein sensitisation, skin 1.1
Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price NIS learning and memory deficits in children 1.28
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor Motor function, impaired 1.33
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton TPO neurodevelopmental outcomes 1.10
Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann Protein alkylation liver fibrosis 1.14

EAGMST Under Review

Open for citation & comment

Title Point of Contact MIE AO OECD Project
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon AFB1 hepatocellular carcinoma 1.8
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard PPAR impaired fertility 1.21
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser CAR hepatocellular adenomas and carcinomas 1.18
Cyp2E1 Activation Leading to Liver Cancer Francina Webster Activation of Cyp2E1 liver cancer 1.24
Disruption of VEGFR Signaling Leading to Developmental Defects Tom Knudsen VEGF developmental outcomes 1.6
Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve ER reproductive dysfunction 1.12
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Justin Teeguarden unclear contact nasal tumors 2.7
PPARα activation in utero leading to impaired fertility in males Elise Grignard PPAR impaired fertility 1.21
Sustained AhR Activation leading to Rodent Liver Tumours Rick Becker AhR liver tumors 1.7

Open for comment. Do not cite

Title Point of Contact MIE AO OECD Project
Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron 1.53
Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Kiyoshi Kushima Calcineurin Activity, Inhibition 1.38

Under development: Not open for comment. Do not cite

Under Development

Open for comment. Do not cite

Title Point of Contact MIE AO OECD Project
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone GR increased disease susceptibility 1.29

Under development: Not open for comment. Do not cite

Title Point of Contact MIE AO OECD Project
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh 5-HTT increased predation 1.29
AhR signalling leading to placental vascular disruption Sabrina Tait 1.42
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood AR adenomas and carcinomas 1.26
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Barnett Rattner 1.31
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken ABCB11 cholestatic liver injury 1.19
Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen 1.35
Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen 1.35
Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen 1.35
Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen 1.35
EGFR Activation Leading to Decreased Lung Function Karsta Luettich EGFR 1.51
Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic Liver, Inflammation 1.47
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Erik Janus 1.41
Kidney dysfunction by decreased thyroid hormone Seokjoo Yoon unclear - KE as MIE? kidnney dysfunction 1.40
Narcosis leading to respiratory failure Dries Knapen undefined sensitisation of the respiratory tract 1.2
Oxidation of iron in hemoglobin leading to hematotoxicity Mitchell S. Wilbanks heme oxidation ? hematotoxicity 1.16
Peptide Oxidation Leading to Hypertension Frazer Lowe 1.50
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno case study 2.5
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi 1.54
Phospholipase A inhibitors lead to hepatotoxicity Seokjoo Yoon phospolipase A hepatotoxicity 1.39
PPARalpha-dependent liver cancer Chris Corton PPAR alpha liver cancer 1.17
PPARα activation leading to impaired fertility in adult male rodents Elise Grignard PPAR α impaired fertility 1.21
Sensitisation of the Respiratory Tract induced by Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins Kristie Sullivan unclear what proteins sensitisation of the respiratory tract 1.20
Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen 1.35
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman mulitple neurodevelopmental outcomes 1.9

Under Development: Contributions and Comments Welcome

Title Point of Contact MIE AO OECD Project
Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve AChE acute mortality 1.3