AOP-Wiki

Title	Point of Contact	MIE	AO	OECD Project
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations	Carole Yauk	Alkylation, DNA	Increase, Heritable mutations in offspring	1.11
Androgen receptor agonism leading to male-biased sex ratio	Dan Villeneuve	Agonism, Androgen receptor	Decrease, Population growth rate	1.12
Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)	Dan Villeneuve	Agonism, Androgen receptor	Decrease, Population growth rate	1.12
Antagonist binding to PPARα leading to body-weight loss	Kurt A. Gust	Binding of antagonist, PPAR alpha	Decreased, Body Weight	2.3
Aromatase inhibition leading to reproductive dysfunction	Dan Villeneuve	Inhibition, Aromatase	Decrease, Population growth rate	1.12
Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2	Markus Hecker	Activation, AhR		1.27
Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF	Amani Farhat	Activation, AhR	Increase, Early Life Stage Mortality	1.7
Aryl hydrocarbon receptor activation leading to uroporphyria	Amani Farhat	Activation, AhR	Uroporphyria	1.7
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.	Anna Price	Binding of agonist, Ionotropic glutamate receptors	Impairment, Learning and memory	1.23
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory	Marie-Gabrielle Zurich	Binding, Thiol/seleno-proteins involved in protection against oxidative stress	Impairment, Learning and memory	1.13
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain	Ping Gong	Binding at picrotoxin site, iGABAR chloride channel	Occurrence, Epileptic seizure	1.15
Chitin synthase 1 inhibition leading to mortality	Simon Schmid	Inhibition, Chitin synthase 1	Increase, Mortality	1.94
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities	Anna Price	Binding of antagonist, NMDA receptors	Impairment, Learning and memory	1.22
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging	Florianne Tschudi-Monnet	Binding of antagonist, NMDA receptors	N/A, Neurodegeneration Impairment, Learning and memory	1.13
Covalent Protein binding leading to Skin Sensitisation	Sharon Munn	Covalent Binding, Protein	sensitisation, skin	1.1
Cyp2E1 Activation Leading to Liver Cancer	Francina Webster	Activation of Cyp2E1	Liver Cancer	1.24
Deposition of energy leading to lung cancer	Vinita Chauhan	Deposition of Energy	Increase, lung cancer	1.56
Disruption of VEGFR Signaling Leading to Developmental Defects	Tom Knudsen	Inhibition, VegfR2	Increased, Developmental Defects	1.6
Histone deacetylase inhibition leading to testicular atrophy	Shihori Tanabe	Histone deacetylase inhibition	Testicular atrophy	1.52
Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response	Takao Ashikaga	Impaired IL-1R1 signaling in T cell	Impairment, T-cell dependent antibody response	1.48
Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment	Anna Price	Inhibition, Na+/I- symporter (NIS)	Impairment, Learning and memory	1.28
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits	Andrea Terron	Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)	Parkinsonian motor deficits	1.33
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Kevin Crofton	Thyroperoxidase, Inhibition	Cognitive Function, Decreased	1.10
Protein Alkylation leading to Liver Fibrosis	Brigitte Landesmann	Alkylation, Protein	N/A, Liver fibrosis	1.14
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation	You Song	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	1.92

Title	Point of Contact	MIE	AO	OECD Project
Inhibitor binding to topoisomerase II leading to infant leukaemia	Andrea Terron	Binding to (interferes with) topoisomerase II enzyme	Infant leukaemia	1.53
Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response	Takumi Ohishi	Inhibition, Calcineurin Activity	Impairment, T-cell dependent antibody response	1.38
Oxidative DNA damage leading to chromosomal aberrations and mutations	Carole Yauk	Increase, Oxidative damage to DNA	Increase, Mutations Increase, Chromosomal aberrations	1.76

Title	Point of Contact	MIE	AO	OECD Project
Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis	Sabina Halappanavar	Substance interaction with the lung resident cell membrane components	Pulmonary fibrosis	1.32

Title	Point of Contact	MIE	AO	OECD Project
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation	Kelvin Santana Rodriguez	Inhibition, Aromatase	Decrease, Population growth rate	1.12
Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation	Dries Knapen	Inhibition, Deiodinase 1	Increased Mortality Decrease, Population growth rate	1.35
Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation	Dries Knapen	Inhibition, Deiodinase 1	Increased Mortality Decrease, Population growth rate	1.35
Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation	Dries Knapen	Inhibition, Deiodinase 2	Increased Mortality Decrease, Population growth rate	1.35
Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation	Dries Knapen	Inhibition, Deiodinase 2	Increased Mortality Decrease, Population growth rate	1.35
Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation	Dries Knapen	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate	1.35

Title	Point of Contact	MIE	AO	OECD Project
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)	Ted Simon	Formation, Pro-mutagenic DNA Adducts	Tumorigenesis, Hepatocellular carcinoma	1.8
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female	Elise Grignard	reduction in ovarian granulosa cells, Aromatase (Cyp19a1)	impaired, Fertility irregularities, ovarian cycle	1.21
Chemical binding to tubulin in oocytes leading to aneuploid offspring	Francesco Marchetti	Binding, Tubulin	Increase, Aneuploid offspring	1.11
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat	Kristin Lichti-Kaiser	Activation, Constitutive androstane receptor	Increase, hepatocellular adenomas and carcinomas	1.17
Estrogen receptor antagonism leading to reproductive dysfunction	Dan Villeneuve	Antagonism, Estrogen receptor	Decrease, Population growth rate	1.12
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors	Justin Teeguarden	Decrease, Intracellular pH	Increase, Site of Contact Nasal Tumors	2.7
PPARα activation in utero leading to impaired fertility in males	Elise Grignard	Activation, PPARα	impaired, Fertility Malformation, Male reproductive tract	1.21
Sustained AhR Activation leading to Rodent Liver Tumours	Rick Becker	Activation, Long term AHR receptor driven direct and indirect gene expression changes	Formation, Hepatocellular and Bile duct tumors	1.7
Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure	Lucia Vergauwen	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate	1.35

Title	Point of Contact	MIE	AO	OECD Project
Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer	Shihori Tanabe	Increases in cellular reactive oxygen species Chronic reactive oxygen species	Treatment-resistant gastric cancer	1.58

Title	Point of Contact	MIE	AO	OECD Project
Adverse outcome pathway on photochemical toxicity initiated by light exposure	Satomi Onoue	ROS generation from photoactivated chemicals	Inflamatory events in light-exposed tissues	1.49
Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity	Prarthana Shankar	Activation, AhR	Increase, Early Life Stage Mortality
Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development	Prarthana Shankar	Activation, AhR	Increase, Early Life Stage Mortality Facial cartilage structures are reduced in size and morphologically distorted
Endocytic lysosomal uptake leading to liver fibrosis	Marina Kuburic	Endocytotic lysosomal uptake	N/A, Liver fibrosis	1.47

Title	Point of Contact	MIE	AO	OECD Project
Inhibition of 5α-reductase leading to impaired fecundity in female fish	Young Jun Kim	Inhibition, 5α-reductase	Decrease, Population growth rate	1.81
Inhibition of tyrosinase leads to decreased population in fish	Young Jun Kim	Inhibition of tyrosinase	Decrease, Population growth rate	1.78
Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death	You Song	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	1.92

Title	Point of Contact	MIE	AO	OECD Project
Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality	Young Jun Kim	Binding to ACE2	Increased Mortality	1.96
Binding to ACE2 leading to lung fibrosis	Young Jun Kim	Induced dysregulation of ACE2	Lung fibrosis	1.96
Inhibition of thyroid peroxidase leading to impaired fertility in fish	June-Woo Park	Thyroperoxidase, Inhibition	Reduction, Cumulative fecundity and spawning	1.59
Lung surfactant function inhibition leading to decreased lung function	Jorid Birkelund Sørli	Inhibition of lung surfactant function	Decrease, Lung function	1.87

Title	Point of Contact	MIE	AO	OECD Project
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)	Charles Wood	Activation, Androgen receptor	Increase, hepatocellular adenomas and carcinomas	1.26
Oxidation of iron in hemoglobin leading to hematotoxicity	Mitchell S. Wilbanks	N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)	N/A, Cyanosis occurs	1.16
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Katie Paul Friedman	Activation, Pregnane-X receptor, NR1l2	Loss, Cochlear function	1.9

Title	Point of Contact	MIE	AO	OECD Project
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage	Barnett Rattner	Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin	Impaired recruitment , Population trajectory	1.31
Peptide Oxidation Leading to Hypertension	Frazer Lowe	Peptide Oxidation	Hypertension	1.50
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol	Jun Kanno	Activation, PXR/SXR		2.5
PPARα activation leading to impaired fertility in adult male rodents	Elise Grignard	Activation, PPARα	impaired, Fertility	1.21
Renal protein alkylation leading to kidney toxicity	Angela Mally	Alkylation, Protein	Occurrence, Kidney toxicity	1.43

Title	Point of Contact	MIE	AO	OECD Project
DNA damage and mutations leading to Metastatic Breast Cancer	Usha Adiga	Increased, DNA damage and mutation	metastatic breast cancer	1.103
5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring	Terje Svingen	Inhibition, 5α-reductase	anogenital distance (AGD), decreased	1.90
AhR activation leading to preeclampsia	Sabrina Tait	Activation, AhR	increase, Preeclampsia	1.42
Androgen receptor (AR) antagonism leading to decreased fertility in females	Terje Svingen	Antagonism, Androgen receptor	Decreased fertility, Reduced number of oocytes ovulated	1.109
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring	Terje Svingen	Antagonism, Androgen receptor	Nipple retention (NR), increased	1.108
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring	Terje Svingen	Antagonism, Androgen receptor	anogenital distance (AGD), decreased	1.90
Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis	Young Jun Kim	Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)	Lung fibrosis	1.96
Antagonism of Smoothened receptor leading to orofacial clefting	Jacob Reynolds	Antagonism, Smoothened receptor	Orofacial clefting	1.101
Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons	Shihori Tanabe	Binding of agonist, Ionotropic glutamate receptors	Impairment, Learning and memory	1.107
Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis	Laure-Alix Clerbaux	Binding to ACE2		1.96
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis	Anna Price	Binding to ACE2	Encephalitis	1.96
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)	Magda Sachana	Binding to ACE2	Cerebrovascular disease (stroke)	1.96
Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption	Laure-Alix Clerbaux	Binding to ACE2		1.96
Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation	Sally Mayasich	Binding to ACE2	Viral infection and host-to-host transmission, proliferated	1.96
Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia	Young Jun Kim	Binding to ACE2	dysgeusia	1.96
Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation	Shihori Tanabe	Binding to ACE2	Thrombosis and Disseminated Intravascular Coagulation	1.96
Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)	Yasuharu Otsubo	Binding to estrogen receptor (ER)-α in immune cells	Exacerbation of systemic lupus erythematosus (SLE)	1.73
Binding to voltage gate sodium channels during development leads to cognitive impairment	Iris Mangas	Binding to voltage-gated sodium channel	Impairment, Learning and memory	1.91
Bulky DNA adducts leading to mutations	Carole Yauk	Bulky DNA adducts, increase	Increase, Mutations	1.11
Chitinase inhibition leading to mortality	Simon Schmid	Inhibition, Chitinase	Increase, Mortality	1.94
Chitobiase inhibition leading to mortality	Simon Schmid	Inhibition, Chitobiase	Increase, Mortality	1.94
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)	Mathieu Vinken	Inhibition, Bile Salt Export Pump (ABCB11)	Cholestasis, Pathology	1.19
Decrease, cholesterol synthesis leads to orofacial clefting	Jacob Reynolds		Orofacial clefting	1.101
Decrease, GLI1/2 target gene expression leads to orofacial clefting	Jacob Reynolds	Decrease, GLI1/2 target gene expression	Orofacial clefting	1.101
Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation	Penny Nymark	Fibrinolysis, decreased Bradykinin system, hyperactivated	Hyperinflammation	1.96
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring	Terje Svingen		anogenital distance (AGD), decreased	1.90
Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk	Andrea Hindman			1.79
EGFR Activation Leading to Decreased Lung Function	Karsta Luettich	Activation, EGFR	Decrease, Lung function	1.51
Endothelial cell dysfunction leading to thromboinflammation	Luigi Margiotta-Casaluci		Thromboinflammation, Increased	1.96
Frustrated phagocytosis-induced lung cancer	Carole Seidel	Frustrated phagocytosis	Lung cancer	1.86
Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia	Kalyan Gayen	Suppression, Estrogen receptor (ER) activity	Promotion, ovarian adenomas Promotion, Ovarian Cancer	1.104
Increased DNA damage leading to increased risk of breast cancer	Jessica Helm	Increase, DNA damage	Increase, Mutations Increased, Ductal Hyperplasia N/A, Breast Cancer	1.80
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer	Jessica Helm	Increase in reactive oxygen and nitrogen species (RONS)	Increase, DNA damage Increase, Mutations Increased, Ductal Hyperplasia N/A, Breast Cancer	1.80
Inhibition of 11β-hydroxylase leading to decresed population trajectory	Young Jun Kim	11β-hydroxylase inhibition	Decrease, Population growth rate	1.93
Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory	Young Jun Kim	Inhibition of 11β-HSD	Decrease, Population growth rate	1.93
Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary	Terje Svingen	Inhibition of ALDH1A (RALDH)	impaired, Fertility	1.97
Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis	Young Jun Kim	Induced dysregulation of ACE2	N/A, Liver fibrosis	1.96
Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response	Yasuhiro Yoshida	Inhibition of JAK3	Impairment of T-cell dependent antibody response	1.74
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity	Angela Mally	Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)	Occurrence, Kidney toxicity	1.43
Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity	Baki Sadi	Inhibition, Mitochondrial Electron Transport Chain Complexes	Occurrence, Kidney toxicity	1.99
Kidney dysfunction by decreased thyroid hormone	Jung-Hwa Oh	Thyroid hormone synthesis, Decreased	Occurrence, Kidney toxicity	1.40
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility	Luigi Margiotta-Casaluci	Blockade, L-Type Calcium Channels	Heart failure	1.45
L-type calcium channel blockade leading to hypotension	Luigi Margiotta-Casaluci			1.45
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology	Luigi Margiotta-Casaluci			1.45
Mitochondrial complexes inhibition leading to heart failure via decreased ATP production	Alexandra Schaffert	Inhibition, Mitochondrial Electron Transport Chain Complexes	Heart failure Increase, Mortality	1.102
Mitochondrial complexes inhibition leading to heart failure via increased myocardial oxidative stress	Sivakumar Murugadoss	Inhibition, Mitochondrial Electron Transport Chain Complexes	Heart failure Increase, Mortality	1.102
Narcosis leading to respiratory failure	Dries Knapen	Accumulation, Biological membranes		1.2
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis	Jinhee Choi	Inactivation of PPARγ	Lung fibrosis	1.54
PPARα activation leading to hepatocellular adenomas and carcinomas in rodents	Chris Corton	Activation, PPARα	Increase, hepatocellular adenomas and carcinomas	1.17
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity	Angela Mally	Binding of substrate, endocytic receptor	Occurrence, Kidney toxicity	1.43
SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)	Sandra Coecke	Binding to ACE2	impaired olfactory function (anosmia)	1.96
Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease	Hiroyuki Komatsu	Stimulation, TLR7/8	Psoriatic skin disease	1.75
Substance interaction with lung resident cell membrane components leading to atherosclerosis	Ulla Vogel	Substance interaction with the lung resident cell membrane components	Atherosclerosis	1.55
Succinate dehydrogenase inactivation leading to cancer	Sylvie Bortoli			1.106
Sulfonylureareceptor binding leading to mortality	Simon Schmid	Increase, Sulfonylurea receptor binding	Increase, Mortality	1.94
Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Kevin Crofton	Antagonism, Thyroid Receptor	Cognitive Function, Decreased	1.84
Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning	Lucia Vergauwen	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate	1.35
Thyroperoxidase inhibition leading to altered visual function via decreased eye size	Lucia Vergauwen	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate	1.35
Trypsin inhibition leading to pancreatic acinar cell tumors	Shigeru Hisada	Trypsin inhibition	Pancreatic acinar cell tumors	1.60
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity	You Song	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	1.92
Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion	You Song	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	1.92
Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium	You Song	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	1.92
Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling	You Song	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	1.92

Title	Point of Contact	MIE	AO	OECD Project
Acetylcholinesterase inhibition leading to acute mortality	Dan Villeneuve	Acetylcholinesterase (AchE) Inhibition	Increased Mortality Decrease, Population growth rate	1.3
Activation of the AhR leading to breast cancer	Louise Benoit	Activation, AhR	N/A, Breast Cancer	1.105
Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response	Jessica Ponder	Covalent Binding, Protein	Increase, Allergic Respiratory Hypersensitivity Response	1.20
Inhibition of retinaldehyde dehydrogenase leads to population decline	Young Jun Kim	Retinaldehyde dehydrogenase inhibition	Decrease, Population growth rate	1.77
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity	Kristie Sullivan	Binding, Transthyretin in serum	Cognitive Function, Decreased	1.41
Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity	Jung-Hwa Oh	Inhibition, Phospholipase A	Formation, Liver fibrosis	1.39

AOPs With OECD Status

WPHA/WNT Endorsed

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Under development: Not open for comment. Do not cite

Under Development: Contributions and Comments Welcome

EAGMST Under Review

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Under development: Not open for comment. Do not cite

Under Development

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Open for adoption

Not under active development

Under development: Not open for comment. Do not cite

Under Development: Contributions and Comments Welcome