AOPs With OECD Status

TFHA/WNT Endorsed

Open for citation & comment

Title Point of Contact MIE AO OECD Project
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk DNA alkylation heritable mutations 1.11
Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve Aromatate Inhib reproductive dysfunction 1.12
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price Glutamate Receptor learning and memory impairment. 1.23
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price NMDAR impairment of learning and memory abilities 1.22
Covalent Protein binding leading to Skin Sensitisation Brigitte Landesmann 1.1
Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann Protein alkylation liver fibrosis 1.14

EAGMST Approved

Open for citation & comment

Title Point of Contact MIE AO OECD Project
Androgen receptor agonism leading to reproductive dysfunction Dan Villeneuve AR reproductive dysfunction 1.12
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet NMDAR neuroinflammation and lead to neurodegeneration 1.13

EAGMST Under Review

Open for citation & comment

Title Point of Contact MIE AO OECD Project
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon AFB1 hepatocellular carcinoma 1.8
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard PPAR impaired fertility 1.21
Chronic Cyp2E1 Activation Leading to Liver Cancer Carole Yauk 1.24
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Richard C. Peffer, Ph.D., DABT CAR hepatocellular adenomas and carcinomas 1.18
Disruption of VEGFR Signaling Leading to Developmental Defects Tom Knudsen VEGF developmental outcomes 1.6
Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve ER reproductive dysfunction 1.12
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor Motor function, impaired 1.33
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton TPO neurodevelopmental outcomes 1.10
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Justin Teeguarden unclear contact nasal tumors 2.7
PPARα activation in utero leading to impaired fertility in males Elise Grignard PPAR impaired fertility 1.21
Sustained AhR Activation leading to Rodent Liver Tumours Rick Becker AhR liver tumors 1.7

Open for comment. Do not cite

Under Development

Under development: Not open for comment. Do not cite

Title Point of Contact MIE AO OECD Project
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh 5-HTT increased predation 1.29
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Kellie Fay 5-HTT increased predation 1.29
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay 1.29
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Kellie Fay 1.29
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Kellie Fay 1.29
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Carlie LaLone unk colony loss/failure 1.29
Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve AChE acute mortality 1.3
AhR activation leading to hepatic steatosis Michelle Angrish AhR hepatic steatosis 1.29
AhR signalling leading to placental vascular disruption Sabrina Tait 1.42
AKT2 activation leading to hepatic steatosis Michelle Angrish AKT2 hepatic steatosis 1.29
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Tammy Stoker alpha Norad Receptors delayed ovulation 1.29
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood Alpha2u adenomas and carcinomas 1.29
Altered ion channel activity leading impaired heart function Kevin Dreher multiple impaired heart function 1.29
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood AR adenomas and carcinomas 1.26
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Charles Wood 1.29
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Barnett Rattner 1.31
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Charles Wood 1.29
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Tammy Stoker 1.29
Axonal sodium channel modulation leading to acute mortality Kellie Fay sodium channel acute mortality 1.29
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Charles Wood 1.29
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins during brain development leads to impairment of learning and memory Florianne Tschudi-Monnet multiple neuroinflammation leading to neurodegeneration 1.13
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken ABCB11 cholestatic liver injury 1.19
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood cytotox is not MIE hepatocellular adenomas and carcinomas 1.29
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Charles Wood 1.29
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Kellie Fay 1.29
Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve cyclooxygenase reproductive failure 1.29
Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt cyclooxygenase reproductive dysfunction 1.29
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Dalma Martinovic-Weigelt cyclooxygenase reproductive dysfunction 1.29
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt cyclooxygenase reproductive dysfunction 1.29
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt cyclooxygenase reproductive dysfunction 1.29
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt cyclooxygenase reproductive dysfunction 1.29
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood cytotox is not MIE bronchioloalveolar adenomas and carcinomas 1.29
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood cytotox is not MIE renal tubular adenomas and carcinomas 1.29
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Carlie LaLone glucose oxidase colony loss/failure 1.29
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Charles Wood AR leydig cell tumors 1.29
Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen 1.35
Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen 1.35
Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen 1.35
Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen 1.35
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman 1.29
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Charles Wood 1.29
EGFR Activation Leading to Decreased Lung Function Karsta Luettich EGFR 1.51
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Charles Wood 1.29
Epigenetic modification of PPARG leading to adipogenesis Michelle Angrish PPARg adipogenesis 1.29
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood cytotox not MIE forestomach tumors 1.29
ER agonism leading to reduced survival due to renal failure Tom Hutchinson ER reduced survival 1.29
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Tom Hutchinson ER altered sexual differentiation 1.29
Estrogen Receptor Activation and Female Precocious Puberty Jeff Welch ER 1.29
Estrogen receptor agonism leading to reproductive dysfunction Tom Hutchinson ER reproductive dysfunction 1.29
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Kellie Fay ERG reduced survival 1.29
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Susan Laws GR decreased male fertitlity 1.29
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone GR increased disease susceptibility 1.29
Glutamate-gated chloride channel activation leading to acute mortality Kellie Fay GluCl Channel acute mortality 1.29
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Charles Wood 1.29
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Charles Wood 1.29
Handbook development AOP Dan Villeneuve 1.29
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman 1.29
Histamine (H2) receptor antagonism leading to reduced survival Kellie Fay H2 reduced survival 1.29
Histone deacetylase inhibition leading to testicular toxicity Takashi Yamada 1.52
HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay HMG-CoA reductase decreased fertility 1.29
HNF4alpha suppression leading to hepatic steatosis Michelle Angrish HNF4alpha hepatic steatosis 1.29
HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood HPPD corneal papillomas and carcinomas 1.29
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood dopamine?? endometrial adenocarcinomas 1.29
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone metabolic stress is not MIE colony loss/failure 1.29
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood 5α-reductase leydig cell tumors 1.29
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood NIS follicular cell adenomas and carcinomas 1.29
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood pyruvate dehydrogenase hepatocellular carcinoma 1.29
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood TPO follicular cell adenomas and carcinomas 1.29
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Erik Janus 1.41
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman 1.29
Kidney dysfunction by decreased thyroid hormone Seokjoo Yoon unclear - KE as MIE? kidnney dysfunction 1.40
Lysosomal damage leading to liver inflammation Brigitte Landesmann Liver, Inflammation 1.47
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Gary Klinefelter GR modulation of leydig cell function 1.29
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Gary Klinefelter proteins - undefined modulation of leydig cell function 1.29
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Gary Klinefelter multiple modulation of leydig cell function 1.29
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Gary Klinefelter estradiol modulation of leydig cell function 1.29
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Gary Klinefelter GR modulation of leydig cell function 1.29
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Gary Klinefelter unk modulation of leydig cell function 1.29
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Gary Klinefelter modulation of leydig cell function 1.29
Narcosis leading to respiratory failure Dries Knapen undefined sensitisation of the respiratory tract 1.2
NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish multiple hepatic steatosis 1.29
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Carlie LaLone nAChR colony loss/failure 1.29
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone nAChR colony loss/failure 1.29
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Carlie LaLone nAChR colony loss/failure 1.29
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Carlie LaLone nAChR colony loss/failure 1.29
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Carlie LaLone nAChR colony loss/failure 1.29
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Carlie LaLone nAChR colony loss/failure 1.29
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Carlie LaLone nAChR colony loss/failure 1.29
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Carlie LaLone 1.29
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Carlie LaLone nAChR colony loss/failure 1.29
Nosema infection causes abnormal role change that leads to colony loss/failure Carlie LaLone 1.29
Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone 1.29
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish PXR hepatic steatosis 1.29
NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish CAR hepatic steatosis 1.29
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay p-amino hippuric acid renal failure and mortality 1.29
Oxidation of iron in hemoglobin leading to hematotoxicity Mitchell S. Wilbanks heme oxidation ? hematotoxicity 1.16
Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman 1.29
Peptide Oxidation Leading to Hypertension Frazer Lowe 1.50
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno case study 2.5
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish b-oxidation fatty acid steatosis 1.29
Phospholipase A inhibitors lead to hepatotoxicity Seokjoo Yoon phospolipase A hepatotoxicity 1.39
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Charles Wood 1.29
PPARalpha-dependent liver cancer Chris Corton PPAR alpha liver cancer 1.17
PPARgamma activation leading to sarcomas in rats, mice, and hamsters Charles Wood 1.29
PPARα activation leading to impaired fertility in adult male rodents Elise Grignard PPAR α impaired fertility 1.21
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt Prolyl hydroxylase reproductive dysfunction 1.29
Queen egg-laying decrease leads to colony loss/failure Carlie LaLone 1.29
Secretion of inflammatory cytokines leading to lung fibrosis Monita Sharma 1.32
Sensitisation of the Respiratory Tract induced by Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins Kristie Sullivan unclear what proteins sensitisation of the respiratory tract 1.20
Sodium channel (Nav1.1) inhibition leading to population decline Kellie Fay 1.29
Sodium channel inhibition leading to congenital malformations Kellie Fay sodium channel congenital malformations 1.29
sodium channel inhibition leading to increased predation Kellie Fay sodium channel increased predation 1.29
Sodium channel inhibition leading to reduced survival Kellie Fay sodium channel reduced survival 1.29
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert NIS neurodevelopmental outcomes 1.29
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Jonathan Haselman 1.29
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone unclear colony loss/failure 1.29
Suppression of immune system contributes to impaired development and leads to colony loss/failure Carlie LaLone unclear colony loss/failure 1.29
Thyroperoxidase inhibition leading to altered amphibian metamorphosis Jonathan Haselman 1.29
Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen 1.35
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman 1.29
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman 1.29
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman 1.29
unknown MIE leading to renal failure and mortality Kellie Fay 1.29
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt Unknown reproductive dysfunction 1.29
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman mulitple neurodevelopmental outcomes 1.9
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood unclear urothelial papillomas and carcinomas 1.29
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Carlie LaLone 1.29
Varroa mite infestation increases virus levels leading to colony loss/failure Carlie LaLone 1.29
Weather event contributes abnormal foraging leading to colony loss/failure Carlie LaLone 1.29
Weather event contributes to colony loss/failure Carlie LaLone 1.29
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Tammy Stoker DBH reduced fecundity 1.29