API XML

Aop: 359

AOP Title

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Chitobiase inhibition leading to mortality

Short name:

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Chitobiase inhibition leading to mortality

Graphical Representation

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Click to download graphical representation template

Authors

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Simon Schmid 1,2, You Song 1, and Knut Erik Tollefsen 1,2

1 Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalléen 21, N-0349, Oslo, Norway

2 Faculty of Environmental Science and Resource Management, Department of Environmental Sciences (IMV), Norwegian University of Life Sciences (NMBU), N-1432, Ås, Norway

Point of Contact

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Simon Schmid   (email point of contact)

Contributors

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  • Simon Schmid
  • You Song
  • Knut Erik Tollefsen

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on October 23, 2020 03:55

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Revision dates for related pages

Page Revision Date/Time
Increase, Chitobiase inhibition October 21, 2020 02:07
Decrease, Digestion of old cuticle October 21, 2020 02:05
Increase, Premature molting October 26, 2020 06:21
Increase, Mortality October 26, 2020 05:18
Increase, Chitobiase inhibition leads to Decrease, Digestion of old cuticle October 21, 2020 02:16
Decrease, Digestion of old cuticle leads to Increase, Premature molting October 21, 2020 02:12
Increase, Premature molting leads to Increase, Mortality October 26, 2020 06:12

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1807 Increase, Chitobiase inhibition Increase, Chitobiase inhibition
KE 996 Decrease, Digestion of old cuticle Decrease, Digestion of old cuticle
KE 1524 Increase, Premature molting Increase, Premature molting
AO 350 Increase, Mortality Increase, Mortality

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, Chitobiase inhibition leads to Decrease, Digestion of old cuticle adjacent Moderate Low
Decrease, Digestion of old cuticle leads to Increase, Premature molting adjacent Moderate Low
Increase, Premature molting leads to Increase, Mortality adjacent Moderate Low

Network View

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Stressors

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Life Stage Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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