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Aop: 128

AOP Title

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Kidney dysfunction by decreased thyroid hormone

Short name:

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Kidney dysfunction

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Seokjoo Yoon   (email point of contact)

Contributors

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  • Seokjoo Yoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.40 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Thyroid hormone synthesis, Decreased May 31, 2018 19:43
Decreased, Thyroxine (T4) in serum September 16, 2017 10:16
Occurrence, Kidney toxicity September 16, 2017 10:16
Decreased, Glomerular filtration September 16, 2017 10:16
Decreased, Renal plasma flow September 16, 2017 10:16
Decreased, Sodium reabsorption September 16, 2017 10:16
Increased, Serum creatinine September 16, 2017 10:16
Occurrence, Cystic dilatation (renal tubule) September 16, 2017 10:16
Occurrence, Cytoplasmic vacuolization (podocyte) September 16, 2017 10:16
Occurrence, Cytoplasmic vacuolization (Renal tubule) September 16, 2017 10:16
Decreased, Renal ability to dilute urine December 03, 2016 16:37
TH synthesis, Decreased leads to Decreased, Thyroxine (T4) in serum December 03, 2016 16:38
TH synthesis, Decreased leads to Increased, Serum creatinine December 03, 2016 16:38
Decreased, Thyroxine (T4) in serum leads to Occurrence, Cytoplasmic vacuolization (Renal tubule) December 03, 2016 16:38
Decreased, Thyroxine (T4) in serum leads to Occurrence, Cystic dilatation (renal tubule) December 03, 2016 16:38
Increased, Serum creatinine leads to Occurrence, Cytoplasmic vacuolization (Renal tubule) December 03, 2016 16:38
Increased, Serum creatinine leads to Occurrence, Cystic dilatation (renal tubule) December 03, 2016 16:38
Decreased, Thyroxine (T4) in serum leads to Occurrence, Cytoplasmic vacuolization (podocyte) December 03, 2016 16:38
Increased, Serum creatinine leads to Occurrence, Cytoplasmic vacuolization (podocyte) December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Glomerular filtration December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Renal plasma flow December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Sodium reabsorption December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Renal ability to dilute urine December 03, 2016 16:38
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Glomerular filtration December 03, 2016 16:38
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Renal plasma flow December 03, 2016 16:38
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Sodium reabsorption December 03, 2016 16:38
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Renal ability to dilute urine December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Glomerular filtration December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Renal plasma flow December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Sodium reabsorption December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Renal ability to dilute urine December 03, 2016 16:38
Decreased, Glomerular filtration leads to Occurrence, Kidney toxicity December 03, 2016 16:38
Decreased, Renal plasma flow leads to Occurrence, Kidney toxicity December 03, 2016 16:38
Decreased, Sodium reabsorption leads to Occurrence, Kidney toxicity December 03, 2016 16:38
Decreased, Renal ability to dilute urine leads to Occurrence, Kidney toxicity December 03, 2016 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 277 Thyroid hormone synthesis, Decreased TH synthesis, Decreased
2 KE 426 Decreased, Thyroxine (T4) in serum Decreased, Thyroxine (T4) in serum
3 KE 819 Decreased, Glomerular filtration Decreased, Glomerular filtration
4 KE 820 Decreased, Renal plasma flow Decreased, Renal plasma flow
5 KE 821 Decreased, Sodium reabsorption Decreased, Sodium reabsorption
6 KE 813 Increased, Serum creatinine Increased, Serum creatinine
7 KE 823 Occurrence, Cystic dilatation (renal tubule) Occurrence, Cystic dilatation (renal tubule)
8 KE 824 Occurrence, Cytoplasmic vacuolization (podocyte) Occurrence, Cytoplasmic vacuolization (podocyte)
9 KE 818 Occurrence, Cytoplasmic vacuolization (Renal tubule) Occurrence, Cytoplasmic vacuolization (Renal tubule)
10 KE 825 Decreased, Renal ability to dilute urine Decreased, Renal ability to dilute urine
11 AO 814 Occurrence, Kidney toxicity Occurrence, Kidney toxicity

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
TH synthesis, Decreased leads to Decreased, Thyroxine (T4) in serum adjacent High
TH synthesis, Decreased leads to Increased, Serum creatinine adjacent High
Decreased, Thyroxine (T4) in serum leads to Occurrence, Cytoplasmic vacuolization (Renal tubule) adjacent Low
Decreased, Thyroxine (T4) in serum leads to Occurrence, Cystic dilatation (renal tubule) adjacent Low
Increased, Serum creatinine leads to Occurrence, Cytoplasmic vacuolization (Renal tubule) adjacent Low
Increased, Serum creatinine leads to Occurrence, Cystic dilatation (renal tubule) adjacent Low
Decreased, Thyroxine (T4) in serum leads to Occurrence, Cytoplasmic vacuolization (podocyte) adjacent Low
Increased, Serum creatinine leads to Occurrence, Cytoplasmic vacuolization (podocyte) adjacent Low
Decreased, Glomerular filtration leads to Occurrence, Kidney toxicity adjacent High
Decreased, Renal plasma flow leads to Occurrence, Kidney toxicity adjacent High
Decreased, Sodium reabsorption leads to Occurrence, Kidney toxicity adjacent High
Decreased, Renal ability to dilute urine leads to Occurrence, Kidney toxicity adjacent High
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Glomerular filtration non-adjacent Low
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Renal plasma flow non-adjacent Low
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Sodium reabsorption non-adjacent Low
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Renal ability to dilute urine non-adjacent Low
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Glomerular filtration non-adjacent Low
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Renal plasma flow non-adjacent Low
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Sodium reabsorption non-adjacent Low
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Renal ability to dilute urine non-adjacent Low
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Glomerular filtration non-adjacent Low
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Renal plasma flow non-adjacent Low
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Sodium reabsorption non-adjacent Low
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Renal ability to dilute urine non-adjacent Low

Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
1 to < 3 months High
Adults High

Taxonomic Applicability

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Term Scientific Term Evidence Link
Sprague-Dawley Sprague-Dawley High NCBI
Homo sapiens Homo sapiens NCBI

Sex Applicability

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Sex Evidence
Male High
Unspecific High

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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