API

Aop: 128

AOP Title

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Kidney dysfunction by decreased thyroid hormone

Short name:

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Kidney dysfunction

Authors

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Point of Contact

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Seokjoo Yoon

Contributors

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  • Seokjoo Yoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.40 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Thyroid hormone synthesis, Decreased September 17, 2017 18:27
Decreased, Thyroxine (T4) in serum September 16, 2017 10:16
Occurrence, Kidney toxicity September 16, 2017 10:16
Decreased, Glomerular filtration September 16, 2017 10:16
Decreased, Renal plasma flow September 16, 2017 10:16
Decreased, Sodium reabsorption September 16, 2017 10:16
Increased, Serum creatinine September 16, 2017 10:16
Occurrence, Cystic dilatation (renal tubule) September 16, 2017 10:16
Occurrence, Cytoplasmic vacuolization (podocyte) September 16, 2017 10:16
Occurrence, Cytoplasmic vacuolization (Renal tubule) September 16, 2017 10:16
Decreased, Renal ability to dilute urine December 03, 2016 16:37
TH synthesis, Decreased leads to Decreased, Thyroxine (T4) in serum December 03, 2016 16:38
TH synthesis, Decreased leads to Increased, Serum creatinine December 03, 2016 16:38
Decreased, Thyroxine (T4) in serum leads to Occurrence, Cytoplasmic vacuolization (Renal tubule) December 03, 2016 16:38
Decreased, Thyroxine (T4) in serum leads to Occurrence, Cystic dilatation (renal tubule) December 03, 2016 16:38
Increased, Serum creatinine leads to Occurrence, Cytoplasmic vacuolization (Renal tubule) December 03, 2016 16:38
Increased, Serum creatinine leads to Occurrence, Cystic dilatation (renal tubule) December 03, 2016 16:38
Decreased, Thyroxine (T4) in serum leads to Occurrence, Cytoplasmic vacuolization (podocyte) December 03, 2016 16:38
Increased, Serum creatinine leads to Occurrence, Cytoplasmic vacuolization (podocyte) December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Glomerular filtration December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Renal plasma flow December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Sodium reabsorption December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Renal ability to dilute urine December 03, 2016 16:38
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Glomerular filtration December 03, 2016 16:38
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Renal plasma flow December 03, 2016 16:38
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Sodium reabsorption December 03, 2016 16:38
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Renal ability to dilute urine December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Glomerular filtration December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Renal plasma flow December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Sodium reabsorption December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Renal ability to dilute urine December 03, 2016 16:38
Decreased, Glomerular filtration leads to Occurrence, Kidney toxicity December 03, 2016 16:38
Decreased, Renal plasma flow leads to Occurrence, Kidney toxicity December 03, 2016 16:38
Decreased, Sodium reabsorption leads to Occurrence, Kidney toxicity December 03, 2016 16:38
Decreased, Renal ability to dilute urine leads to Occurrence, Kidney toxicity December 03, 2016 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Thyroid hormone synthesis, Decreased TH synthesis, Decreased

Key Events

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Title Short name
Decreased, Thyroxine (T4) in serum Decreased, Thyroxine (T4) in serum
Decreased, Glomerular filtration Decreased, Glomerular filtration
Decreased, Renal plasma flow Decreased, Renal plasma flow
Decreased, Sodium reabsorption Decreased, Sodium reabsorption
Increased, Serum creatinine Increased, Serum creatinine
Occurrence, Cystic dilatation (renal tubule) Occurrence, Cystic dilatation (renal tubule)
Occurrence, Cytoplasmic vacuolization (podocyte) Occurrence, Cytoplasmic vacuolization (podocyte)
Occurrence, Cytoplasmic vacuolization (Renal tubule) Occurrence, Cytoplasmic vacuolization (Renal tubule)
Decreased, Renal ability to dilute urine Decreased, Renal ability to dilute urine

Adverse Outcome

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Title Short name
Occurrence, Kidney toxicity Occurrence, Kidney toxicity

Relationships Between Two Key Events (Including MIEs and AOs)

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Title Directness Evidence Quantitative Understanding
TH synthesis, Decreased leads to Decreased, Thyroxine (T4) in serum Directly leads to Strong
TH synthesis, Decreased leads to Increased, Serum creatinine Directly leads to Strong
Decreased, Thyroxine (T4) in serum leads to Occurrence, Cytoplasmic vacuolization (Renal tubule) Directly leads to Weak
Decreased, Thyroxine (T4) in serum leads to Occurrence, Cystic dilatation (renal tubule) Directly leads to Weak
Increased, Serum creatinine leads to Occurrence, Cytoplasmic vacuolization (Renal tubule) Directly leads to Weak
Increased, Serum creatinine leads to Occurrence, Cystic dilatation (renal tubule) Directly leads to Weak
Decreased, Thyroxine (T4) in serum leads to Occurrence, Cytoplasmic vacuolization (podocyte) Directly leads to Weak
Increased, Serum creatinine leads to Occurrence, Cytoplasmic vacuolization (podocyte) Directly leads to Weak
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Glomerular filtration Indirectly leads to Weak
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Renal plasma flow Indirectly leads to Weak
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Sodium reabsorption Indirectly leads to Weak
Occurrence, Cytoplasmic vacuolization (Renal tubule) leads to Decreased, Renal ability to dilute urine Indirectly leads to Weak
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Glomerular filtration Indirectly leads to Weak
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Renal plasma flow Indirectly leads to Weak
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Sodium reabsorption Indirectly leads to Weak
Occurrence, Cystic dilatation (renal tubule) leads to Decreased, Renal ability to dilute urine Indirectly leads to Weak
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Glomerular filtration Indirectly leads to Weak
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Renal plasma flow Indirectly leads to Weak
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Sodium reabsorption Indirectly leads to Weak
Occurrence, Cytoplasmic vacuolization (podocyte) leads to Decreased, Renal ability to dilute urine Indirectly leads to Weak
Decreased, Glomerular filtration leads to Occurrence, Kidney toxicity Directly leads to Strong
Decreased, Renal plasma flow leads to Occurrence, Kidney toxicity Directly leads to Strong
Decreased, Sodium reabsorption leads to Occurrence, Kidney toxicity Directly leads to Strong
Decreased, Renal ability to dilute urine leads to Occurrence, Kidney toxicity Directly leads to Strong

Network View

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Life Stage Applicability

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Life stage Evidence
1 to < 3 months Strong
Adults Strong

Taxonomic Applicability

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Term Scientific Term Evidence Link
Sprague-Dawley Sprague-Dawley Strong NCBI
Homo sapiens Homo sapiens NCBI

Sex Applicability

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Sex Evidence
Male Strong
Unspecific Strong

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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