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Aop: 159

AOP Title

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Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation

Short name:

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TPOi anterior swim bladder

Graphical Representation

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Click to download graphical representation template

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Authors

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Dries Knapen [1], [dries.knapen (at)uantwerpen.be]

Lucia Vergauwen [1], [lucia.vergauwen(at)uantwerpen.be]

Evelyn Stinckens [1], [evelyn.stinckens(at)uantwerpen.be]

Dan Villeneuve [2], [villeneuve.dan*(at)epa.gov]

[1] Zebrafishlab, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
[2]United States Environmental Protection Agency, Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, USA.

Point of Contact

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Dries Knapen   (email point of contact)

Contributors

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  • Dries Knapen

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.35 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Thyroperoxidase, Inhibition May 31, 2018 19:38
Decrease, Population trajectory September 26, 2017 11:33
Thyroid hormone synthesis, Decreased May 31, 2018 19:43
Thyroxine (T4) in serum, Decreased June 02, 2018 09:41
Reduced, Anterior swim bladder inflation November 29, 2016 19:36
Reduced, Hearing November 29, 2016 19:36
Reduced, Swimming performance November 29, 2016 19:36
Reduced, Young of year survival November 29, 2016 19:36
Reduced, Anterior swim bladder inflation leads to Reduced, Hearing December 03, 2016 16:38
Reduced, Hearing leads to Reduced, Young of year survival December 03, 2016 16:38
T4 in serum, Decreased leads to Reduced, Anterior swim bladder inflation November 29, 2016 20:52
Reduced, Young of year survival leads to Decrease, Population trajectory December 03, 2016 16:38
Reduced, Anterior swim bladder inflation leads to Reduced, Swimming performance November 29, 2016 20:52
Reduced, Swimming performance leads to Reduced, Young of year survival December 03, 2016 16:38
Thyroperoxidase, Inhibition leads to TH synthesis, Decreased June 02, 2018 09:52
TH synthesis, Decreased leads to T4 in serum, Decreased June 04, 2018 06:03
Thyroperoxidase, Inhibition leads to T4 in serum, Decreased June 02, 2018 10:56
Methimazole November 29, 2016 18:42
Mercaptobenzothiazole November 29, 2016 18:42
Propylthiouracil November 29, 2016 18:42

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 279 Thyroperoxidase, Inhibition Thyroperoxidase, Inhibition
2 KE 277 Thyroid hormone synthesis, Decreased TH synthesis, Decreased
3 KE 281 Thyroxine (T4) in serum, Decreased T4 in serum, Decreased
4 KE 1007 Reduced, Anterior swim bladder inflation Reduced, Anterior swim bladder inflation
5 KE 1008 Reduced, Hearing Reduced, Hearing
6 KE 1005 Reduced, Swimming performance Reduced, Swimming performance
7 KE 1006 Reduced, Young of year survival Reduced, Young of year survival
8 AO 360 Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Reduced, Anterior swim bladder inflation leads to Reduced, Hearing adjacent
Reduced, Hearing leads to Reduced, Young of year survival adjacent
T4 in serum, Decreased leads to Reduced, Anterior swim bladder inflation adjacent
Reduced, Young of year survival leads to Decrease, Population trajectory adjacent
Reduced, Anterior swim bladder inflation leads to Reduced, Swimming performance adjacent
Reduced, Swimming performance leads to Reduced, Young of year survival adjacent
Thyroperoxidase, Inhibition leads to TH synthesis, Decreased adjacent
TH synthesis, Decreased leads to T4 in serum, Decreased adjacent
Thyroperoxidase, Inhibition leads to T4 in serum, Decreased non-adjacent

Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
Development

Taxonomic Applicability

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Term Scientific Term Evidence Link
zebrafish Danio rerio NCBI
fathead minnow Pimephales promelas NCBI

Sex Applicability

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Sex Evidence
Unspecific

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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