API

Aop: 159

AOP Title

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Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation

Short name:

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TPOi anterior swim bladder

Authors

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Dries Knapen [1], [dries.knapen (at)uantwerpen.be]

Lucia Vergauwen [1], [lucia.vergauwen(at)uantwerpen.be]

Evelyn Stinckens [1], [evelyn.stinckens(at)uantwerpen.be]

Dan Villeneuve [2], [villeneuve.dan*(at)epa.gov]

[1] Zebrafishlab, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
[2]United States Environmental Protection Agency, Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, USA.

Point of Contact

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Dries Knapen

Contributors

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  • Dries Knapen

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.35 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Thyroperoxidase, Inhibition September 16, 2017 10:15
Decrease, Population trajectory September 26, 2017 11:33
Thyroid hormone synthesis, Decreased September 17, 2017 18:27
Thyroxine (T4) in serum, Decreased September 17, 2017 18:37
Reduced, Anterior swim bladder inflation November 29, 2016 19:36
Reduced, Hearing November 29, 2016 19:36
Reduced, Swimming performance November 29, 2016 19:36
Reduced, Young of year survival November 29, 2016 19:36
Reduced, Anterior swim bladder inflation leads to Reduced, Hearing December 03, 2016 16:38
Reduced, Hearing leads to Reduced, Young of year survival December 03, 2016 16:38
T4 in serum, Decreased leads to Reduced, Anterior swim bladder inflation November 29, 2016 20:52
Reduced, Young of year survival leads to Decrease, Population trajectory December 03, 2016 16:38
Reduced, Anterior swim bladder inflation leads to Reduced, Swimming performance November 29, 2016 20:52
Reduced, Swimming performance leads to Reduced, Young of year survival December 03, 2016 16:38
Thyroperoxidase, Inhibition leads to TH synthesis, Decreased September 17, 2017 17:22
TH synthesis, Decreased leads to T4 in serum, Decreased September 17, 2017 17:36
Thyroperoxidase, Inhibition leads to T4 in serum, Decreased September 17, 2017 19:27
Methimazole November 29, 2016 18:42
Mercaptobenzothiazole November 29, 2016 18:42
Propylthiouracil November 29, 2016 18:42

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Thyroperoxidase, Inhibition Thyroperoxidase, Inhibition

Key Events

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Title Short name
Thyroid hormone synthesis, Decreased TH synthesis, Decreased
Thyroxine (T4) in serum, Decreased T4 in serum, Decreased
Reduced, Anterior swim bladder inflation Reduced, Anterior swim bladder inflation
Reduced, Hearing Reduced, Hearing
Reduced, Swimming performance Reduced, Swimming performance
Reduced, Young of year survival Reduced, Young of year survival

Adverse Outcome

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Title Short name
Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Development

Taxonomic Applicability

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Term Scientific Term Evidence Link
zebrafish Danio rerio NCBI
fathead minnow Pimephales promelas NCBI

Sex Applicability

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Sex Evidence
Unspecific

Graphical Representation

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Click to download graphical representation template

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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