Upstream eventIncreased Mortality
Decrease, Population trajectory
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding|
|Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement||adjacent|
|Acetylcholinesterase inhibition leading to acute mortality||adjacent||Moderate||Moderate|
Life Stage Applicability
|All life stages||High|
Key Event Relationship Description
- Increased mortality in the reproductive population may lead to a declining population.
Evidence Supporting this KER
- Survival to reproductive maturity is a parameter of demographic significance. Assuming resource availability (i.e., food, habitat, etc.) is not limiting to the extant population, sufficient mortality in the reproductive population may ultimately lead to declining population trajectories.
Uncertainties and Inconsistencies
There are scenarios in which individual mortality may not lead to declining population size. These include instances where populations are limited by the availability of habitat and food resources, which can be replenished through immigration.
The direct impact of pesticides on migration behavior can be difficult to track in the field, and documentation of mortality during migration is likely underestimated (Eng 2017).
Quantitative Understanding of the Linkage
- Assuming other relevant demographic parameters are available, the effect of increased mortality rates on population status can be quantitatively predicted using standard population modeling approaches.
Known modulating factors
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
- All organisms must survive to reproductive age in order to reproduce and sustain populations.
- Eng, M.L., Stutchbury, B.J.M. & Morrissey, C.A. Imidacloprid and chlorpyrifos insecticides impair migratory ability in a seed-eating songbird. Sci Rep 7, 15176 (2017)