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Aop: 312

AOP Title

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Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​

Short name:

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AChE inhibition - acute mortality via predation

Graphical Representation

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Click to download graphical representation template

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Authors

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CHRISTINE L. RUSSOM (1), DANIEL L. VILLENEUVE* (2), VIRGINIA HENCH (3), CATAIA IVES (3), VIRGINIA C. MOSER (1), CARLIE A. LALONE (2), STEPHEN EDWARDS (3), KRISTIE SULLIVAN (4), and GERALD T. ANKLEY (2)

(1) U.S. Environmental Protection Agency (Retired)

(2) National Health and Environmental Effects Research Laboratory, Office of Research and Development, Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota, USA

(3) Research Computing Division, RTI International, Research Triangle Park, North Carolina, USA

(4) Physicians Committee for Responsible Medicine, Washington, DC, USA

  • Corresponding author for wiki entry (Villeneuve.dan@epa.gov)

Point of Contact

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Kristie Sullivan   (email point of contact)

Contributors

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  • Stephen Edwards
  • Ginnie Hench
  • Cataia Ives
  • Dan Villeneuve
  • Kristie Sullivan

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on December 23, 2019 14:41

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Revision dates for related pages

Page Revision Date/Time
Acetylcholinesterase (AchE) Inhibition April 29, 2020 17:21
Acetylcholine accumulation in synapses June 26, 2020 13:06
Increased Cholinergic Signaling December 20, 2019 17:32
Impaired coordination and movement December 20, 2019 15:59
Increased Mortality December 20, 2019 17:34
Decrease, Population trajectory September 26, 2017 11:33
AchE Inhibition leads to ACh Synaptic Accumulation December 19, 2019 15:57
AchE Inhibition leads to Increased Cholinergic Signaling December 20, 2019 11:07
ACh Synaptic Accumulation leads to Increased Cholinergic Signaling December 20, 2019 09:16
AchE Inhibition leads to Impaired coordination and movement December 20, 2019 16:11
Increased Cholinergic Signaling leads to Impaired coordination and movement December 20, 2019 16:05
Impaired coordination and movement leads to Decrease, Population trajectory December 20, 2019 16:18
Impaired coordination and movement leads to Increased Mortality December 20, 2019 16:06
Increased Mortality leads to Decrease, Population trajectory December 20, 2019 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 12 Acetylcholinesterase (AchE) Inhibition AchE Inhibition
KE 10 Acetylcholine accumulation in synapses ACh Synaptic Accumulation
KE 39 Increased Cholinergic Signaling Increased Cholinergic Signaling
KE 1705 Impaired coordination and movement Impaired coordination and movement
AO 351 Increased Mortality Increased Mortality
AO 360 Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
AchE Inhibition leads to ACh Synaptic Accumulation adjacent
ACh Synaptic Accumulation leads to Increased Cholinergic Signaling adjacent
Increased Cholinergic Signaling leads to Impaired coordination and movement adjacent
Impaired coordination and movement leads to Increased Mortality adjacent
Increased Mortality leads to Decrease, Population trajectory adjacent
AchE Inhibition leads to Increased Cholinergic Signaling non-adjacent
AchE Inhibition leads to Impaired coordination and movement non-adjacent
Impaired coordination and movement leads to Decrease, Population trajectory non-adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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