API

Aop: 157

AOP Title

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Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation

Short name:

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DIO1i posterior swim bladder

Authors

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Dries Knapen [1], [dries.knapen (at)uantwerpen.be]

Lucia Vergauwen [1], [lucia.vergauwen(at)uantwerpen.be]

Evelyn Stinckens [1], [evelyn.stinckens(at)uantwerpen.be]

Dan Villeneuve [2], [villeneuve.dan*(at)epa.gov]

[1] Zebrafishlab, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
[2]United States Environmental Protection Agency, Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, USA.

Point of Contact

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Dries Knapen

Contributors

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  • Dries Knapen

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.35 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Inhibition, Deiodinase 1 November 29, 2016 19:36
Decrease, Population trajectory September 26, 2017 11:33
Decreased, Triiodothyronine (T3) in serum September 26, 2017 11:03
Reduced, Posterior swim bladder inflation November 29, 2016 19:36
Reduced, Swimming performance November 29, 2016 19:36
Reduced, Young of year survival November 29, 2016 19:36
Reduced, Anterior swim bladder inflation November 29, 2016 19:36
Reduced, Hearing November 29, 2016 19:36
Inhibition, Deiodinase 1 leads to Decreased, Triiodothyronine (T3) in serum December 03, 2016 16:38
Decreased, Triiodothyronine (T3) in serum leads to Reduced, Posterior swim bladder inflation December 03, 2016 16:38
Reduced, Posterior swim bladder inflation leads to Reduced, Swimming performance November 29, 2016 20:51
Reduced, Swimming performance leads to Reduced, Young of year survival December 03, 2016 16:38
Reduced, Young of year survival leads to Decrease, Population trajectory December 03, 2016 16:38
Reduced, Posterior swim bladder inflation leads to Reduced, Anterior swim bladder inflation December 03, 2016 16:38
Reduced, Anterior swim bladder inflation leads to Reduced, Hearing December 03, 2016 16:38
Reduced, Hearing leads to Reduced, Young of year survival December 03, 2016 16:38
Reduced, Anterior swim bladder inflation leads to Reduced, Swimming performance November 29, 2016 20:52
Inhibition, Deiodinase 1 leads to Reduced, Posterior swim bladder inflation November 29, 2016 20:53
Reduced, Posterior swim bladder inflation leads to Reduced, Young of year survival November 29, 2016 20:52
Propylthiouracil November 29, 2016 18:42

Abstract

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The AOP describes the effects of inhibition of deiodinase 1 (DIO1) on posterior swim bladder inflation leading to reduced young of year survival and population trajectory decline. The inhibition of DIO1 is the molecular-initiating event (MIE), which results in decreased circulating concentrations of triiodothyronine (T3) in serum. Disruption of the thyroid hormone (TH) system is increasingly being recognized as an important MoA that can lead to adverse outcomes, especially during embryonic development. In fish, many different adverse effects during early development resulting from disruption of the TH endocrine system have been reported (e.g., effects on body and eye size, head-to-trunk angle, heartbeat, otolith formation, pigmentation index, swim bladder inflation, hatching time, somite formation, escape response and photoreceptor development). As in amphibians, the transition in fish between the different developmental phases, including maturation and inflation of the swim bladder, have been shown to be mediated by THs. Fish larvae exposed to PTU, a known DIO1 inhibitor, has been known to result in impairment of the posterior chamber inflation. Chemicals interfering with the conversion of T4 to T3 have the potential to inhibit posterior chamber inflation which may result in reduced swimming capacity of the fish, a relevant adverse outcome that can affect feeding behaviour and predator avoidance, resulting in lower survival probability and ultimately population trajectory decline (Czesny et al., 2005; Woolley and Qin, 2010).


Background (optional)

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Summary of the AOP

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Stressors

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Name Evidence Term
Propylthiouracil

Molecular Initiating Event

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Title Short name
Inhibition, Deiodinase 1 Inhibition, Deiodinase 1

Key Events

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Title Short name
Decreased, Triiodothyronine (T3) in serum Decreased, Triiodothyronine (T3) in serum
Reduced, Posterior swim bladder inflation Reduced, Posterior swim bladder inflation
Reduced, Swimming performance Reduced, Swimming performance
Reduced, Young of year survival Reduced, Young of year survival
Reduced, Anterior swim bladder inflation Reduced, Anterior swim bladder inflation
Reduced, Hearing Reduced, Hearing

Adverse Outcome

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Title Short name
Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Development

Taxonomic Applicability

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Term Scientific Term Evidence Link
zebrafish Danio rerio NCBI
fathead minnow Pimephales promelas NCBI

Sex Applicability

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Sex Evidence
Unspecific

Graphical Representation

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Click to download graphical representation template

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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