Upstream eventInhibition, Deiodinase 1
Decreased, Triiodothyronine (T3) in serum
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding|
|Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation||adjacent|
|Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation||adjacent|
|fathead minnow||Pimephales promelas||NCBI|
Life Stage Applicability
Key Event Relationship Description
Evidence Supporting this KER
Inhibition of DIO 1 and 2 activity is widely accepted to directly impact the T3 levels in serum, since the convertion of T4 to T3 is inhibited.
Uncertainties and Inconsistencies
Quantitative Understanding of the Linkage
Known modulating factors
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
Mol et al. (1998) concluded concluded that deiodinases in teleosts were more similar to mammalian deiodinases than had been generally accepted, based on the similarities in susceptibility to inhibition and the agreement of the Km values.
Mol, K.A., Van der Geyten, S., Burel, C., Kuhn, E.R., Boujard, T., Darras, V.M., 1998. Comparative study of iodothyronine outer ring and inner ring deiodinase activities in five teleostean fishes. Fish Physiology and Biochemistry 18, 253-266.