API

Relationship: 1037

Title

?

Inhibition, Deiodinase 1 leads to Decreased, Triiodothyronine (T3) in serum

Upstream event

?

Inhibition, Deiodinase 1

Downstream event

?


Decreased, Triiodothyronine (T3) in serum

Key Event Relationship Overview

?


AOPs Referencing Relationship

?


Taxonomic Applicability

?

Term Scientific Term Evidence Link
zebrafish Danio rerio NCBI
fathead minnow Pimephales promelas NCBI

Sex Applicability

?


Life Stage Applicability

?


How Does This Key Event Relationship Work

?


Weight of Evidence

?


Biological Plausibility

?

Inhibition of DIO activity is widely accepted to directly impact the T3 levels in serum, since the convertion of T4 to T3 is inhibited.

Empirical Support for Linkage

?

Uncertainties or Inconsistencies

?

Quantitative Understanding of the Linkage

?


Evidence Supporting Taxonomic Applicability

?


References

?