API

Stressor: 37

Title

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Methimazole

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Methimazole DTXSID4020820 Methimazole 60-56-0 PMRYVIKBURPHAH-UHFFFAOYSA-N PMRYVIKBURPHAH-UHFFFAOYSA-N

AOP Evidence

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Thyroperoxidase inhibition leading to altered amphibian metamorphosis

There is no evidence text for this AOP



Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation

There is no evidence text for this AOP



Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals

There is no evidence text for this AOP




Event Evidence

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Thyroperoxidase, Inhibition

There is no evidence text for this event.



Thyroxine (T4) in serum, Decreased

Classic positive control



Thyroid hormone synthesis, Decreased

Methimazole is a very common positve control



Thyroxine (T4) in neuronal tissue, Decreased

There is no evidence text for this event.



Hippocampal gene expression, Altered

There is no evidence text for this event.



Hippocampal anatomy, Altered

There is no evidence text for this event.



Hippocampal Physiology, Altered

There is no evidence text for this event.



Cognitive Function, Decreased

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Instructions

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Characterization of Exposure

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Instructions

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References

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List the bibliographic references to original papers, books or other documents used to support the Stressor.

Instructions

To edit the “References” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “References” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “References” section on the page.