Stressor: 37
Title
Stressor Overview
AOPs Including This Stressor
Events Including This Stressor
Chemical Table
| User term | DTXID | Preferred name | Casrn | jchem_inchi_key | indigo_inchi_key |
|---|---|---|---|---|---|
| Methimazole | DTXSID4020820 | Methimazole | 60-56-0 | PMRYVIKBURPHAH-UHFFFAOYSA-N | PMRYVIKBURPHAH-UHFFFAOYSA-N |
AOP Evidence
Thyroperoxidase inhibition leading to altered amphibian metamorphosis
There is no evidence text for this AOP
Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation
There is no evidence text for this AOP
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
There is no evidence text for this AOP
Inhibition of thyroid peroxidase leading to impaired fertility in fish
There is no evidence text for this AOP
Event Evidence
Thyroperoxidase, Inhibition
There is no evidence text for this event.
Thyroxine (T4) in serum, Decreased
Classic positive control
Thyroid hormone synthesis, Decreased
Methimazole is a very common positve control
Thyroxine (T4) in neuronal tissue, Decreased
There is no evidence text for this event.
Hippocampal gene expression, Altered
There is no evidence text for this event.
Hippocampal anatomy, Altered
There is no evidence text for this event.
Hippocampal Physiology, Altered
There is no evidence text for this event.
Cognitive Function, Decreased
There is no evidence text for this event.
Decreased, Thyroxine (T4) in tissues
Inferred given effect of reduced thyroid hormone synthesis on lack of metamorphic changes in tissues.
Decreased, Triiodothyronine (T3) in tissues
Inferred given effect of reduced thyroid hormone synthesis on lack of metamorphic changes in tissues.
Altered, Amphibian metamorphosis
Methimazole exposure during prometamorphosis in Xenopus laevis causes delayed/arrested metamorphosis.