Help: Stressors

01 To Create a New Stressor


Stressor ID

Each Stressor is automatically given a numerical identifier when it is created.

Title

To create a new stressor, from the Listing Stressors page at https://aopwiki.org/stressors click ‘New stressor.’ This will bring you to a page entitled “New Stressor” where a stressor title can be entered. Click ‘Create stressor’ to create a new Stressor page listing the stressor title at the top.

02 To Edit Stressor Overview


Overview

The stressor field is a structured data field that can be used to annotate an AOP with standardised terms identifying stressors known to trigger the MIE/AOP. Most often these are chemical names selected from established chemical ontologies. However, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical stressors such as genetic or environmental factors.

AOPs Including this Stressor

This table is automatically generated and lists the AOPs associated with this Stressor.

Events Including this Stressor

This table is automatically generated and lists the Key Events associated with this Stressor.

Chemicals

The Chemical Table lists chemicals associated with a stressor. This table contains information about the User’s term for a chemical, the DTXID, Preferred name, CAS number, JChem InChIKey, and Indigo InChIKey.

To add a chemical associated with a particular stressor, next to the Chemical Table click ‘Add chemical.’ This will redirect you to a page entitled “New Stressor Chemical.’ The dialog box can be used to search for chemical by name, CAS number, JChem InChIKey, and Indigo InChIKey. Searching by these fields will bring forward a drop down list of existing stressor chemicals formatted as  "Preferred name," “CAS- preferred name,” “JChem InChIKey – preferred name,” or “Indigo InChIKey- preferred name,” depending on by which field you perform the search. It may take several moments for the drop down list to display. Select an entity from the drop down list and click ‘Add chemical.’ This will return you to the Stressor Page, where the new record should be in the ‘Chemical Table’ on the page.

To remove a chemical associated with a particular stressor, in the Chemical Table next to the chemical you wish to delete, click ‘Remove’ and then click 'OK.' The chemical should no longer be visible in the Chemical table.

03 To View Evidence for this Stressor


AOP Evidence

This table is automatically generated and includes the AOPs with this associated stressor as well as the evidence term and evidence text from this AOP Stressor.

Event Evidence

This table is automatically generated and includes the Events with this associated stressor as well as the evidence text from this Event Stressor.

04 To Edit Stressor Info Text Sections


Stressor Info

Text sections under this subheading include the Chemical/Category Description and Characterization of Exposure.

Chemical/Category Description

To edit the "Chemical/Category Description” section, on a KER page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Chemical/Category Description” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Chemical/Category Description”  section on the page.

Characterization of Exposure

To edit the “Characterization of Exposure” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Characterization of Exposure”  section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Characterization of Exposure” section on the page.

05 To Add References to a Stressor


References

List of the literature that was cited for this Stressor description. Ideally, the list of references, should conform, to the extent possible, with the OECD Style Guide (https://www.oecd.org/about/publishing/OECD-Style-Guide-Third-Edition.pdf) (OECD, 2015).

To edit the “References” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “References” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “References” section on the page.

06 Other Stressor Information


Stressor Comments and Discussion

See here for further instructions on how to comment and contribute to discussion.

View Stressor History

To view detailed changes to an AOP, KE, KER, or Stressor page, click 'View History' on the upper right hand panel menu on the page. You will be brought to a page entitled "Versions of [AOP/KE/KER/Stressor:#]" listing text changes to the AOP/KE/KER/Stressor by date. To compare two versions, select the versions you would like to compare using the "from" and "to" buttons.  Click 'Compare.' You will be brought to a page showing the comparison of the two versions. If you are a contributor to this AOP, you can also click 'revert to this version' at the bottom of the page to revert to a previous version of an AOP/KE/KER/Stressor.

The Change log lists all changes to an AOP/KE/KER/Stressor including text changes, the date and the user who made the change.

 

Stressor Watch list

The Watch List provides a list of individual AOP, KE, KER, or Stressor that a user is currently watching, similar to Bookmarks on an internet browser.

To add a page to the Watch List, navigate to the indivdual AOP, KE, KER, or Stressor page and in the upper right hand navigation menu, click 'Watch.' To remove a page from the Watch List, click 'Watch' to unselect the check box.