API XML

Aop: 271

AOP Title

?


Inhibition of thyroid peroxidase leading to impaired fertility in fish

Short name:

?

TPO inhibition and impaired fertility

Graphical Representation

?

Click to download graphical representation template

W1siziisijiwmtgvmtevmtmvmxzicxjsywxsaf9bt1bfmjcxlmpwzyjdlfsiccisinrodw1iiiwintaweduwmcjdxq?sha=62b40c3ec5149e65

Authors

?


June-Woo Park, Korea Institute of Toxicology

Carlie LaLone, US EPA

Point of Contact

?


June-Woo Park   (email point of contact)

Contributors

?


  • June-Woo Park
  • Carlie LaLone

Status

?

Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on November 12, 2018 23:25

?

Revision dates for related pages

Page Revision Date/Time
Thyroperoxidase, Inhibition August 07, 2018 15:09
Thyroid hormone synthesis, Decreased August 11, 2018 13:21
Reduction, Plasma 17beta-estradiol concentrations September 26, 2017 11:30
Reduction, Plasma vitellogenin concentrations September 16, 2017 10:14
Reduction, Cumulative fecundity and spawning March 20, 2017 17:52
Thyroperoxidase, Inhibition leads to TH synthesis, Decreased August 11, 2018 19:01
TH synthesis, Decreased leads to Reduction, Plasma 17beta-estradiol concentrations September 18, 2018 20:54
Reduction, Plasma 17beta-estradiol concentrations leads to Reduction, Plasma vitellogenin concentrations October 18, 2018 11:02
Reduction, Plasma vitellogenin concentrations leads to Reduction, Cumulative fecundity and spawning September 18, 2018 20:55

Abstract

?



Background (optional)

?



Summary of the AOP

?


Events: Molecular Initiating Events (MIE)

?

Key Events (KE)

?

Adverse Outcomes (AO)

?

Sequence Type Event ID Title Short name
MIE 279 Thyroperoxidase, Inhibition Thyroperoxidase, Inhibition
KE 277 Thyroid hormone synthesis, Decreased TH synthesis, Decreased
KE 219 Reduction, Plasma 17beta-estradiol concentrations Reduction, Plasma 17beta-estradiol concentrations
KE 221 Reduction, Plasma vitellogenin concentrations Reduction, Plasma vitellogenin concentrations
AO 78 Reduction, Cumulative fecundity and spawning Reduction, Cumulative fecundity and spawning

Relationships Between Two Key Events
(Including MIEs and AOs)

?

Title Adjacency Evidence Quantitative Understanding
Thyroperoxidase, Inhibition leads to TH synthesis, Decreased adjacent
TH synthesis, Decreased leads to Reduction, Plasma 17beta-estradiol concentrations adjacent
Reduction, Plasma 17beta-estradiol concentrations leads to Reduction, Plasma vitellogenin concentrations adjacent
Reduction, Plasma vitellogenin concentrations leads to Reduction, Cumulative fecundity and spawning adjacent

Network View

?

 

Stressors

?

Life Stage Applicability

?

Taxonomic Applicability

?

Sex Applicability

?

Overall Assessment of the AOP

?



Domain of Applicability

?


Essentiality of the Key Events

?


Evidence Assessment

?


Quantitative Understanding

?


Considerations for Potential Applications of the AOP (optional)

?



References

?