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Event: 78

Key Event Title

A descriptive phrase which defines a discrete biological change that can be measured. More help

Reduction, Cumulative fecundity and spawning

Short name
The KE short name should be a reasonable abbreviation of the KE title and is used in labelling this object throughout the AOP-Wiki. More help
Reduction, Cumulative fecundity and spawning
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Biological Context

Structured terms, selected from a drop-down menu, are used to identify the level of biological organization for each KE. More help
Level of Biological Organization
Individual

Key Event Components

The KE, as defined by a set structured ontology terms consisting of a biological process, object, and action with each term originating from one of 14 biological ontologies (Ives, et al., 2017; https://aopwiki.org/info_pages/2/info_linked_pages/7#List). Biological process describes dynamics of the underlying biological system (e.g., receptor signalling).Biological process describes dynamics of the underlying biological system (e.g., receptor signaling).  The biological object is the subject of the perturbation (e.g., a specific biological receptor that is activated or inhibited). Action represents the direction of perturbation of this system (generally increased or decreased; e.g., ‘decreased’ in the case of a receptor that is inhibited to indicate a decrease in the signaling by that receptor).  Note that when editing Event Components, clicking an existing Event Component from the Suggestions menu will autopopulate these fields, along with their source ID and description.  To clear any fields before submitting the event component, use the 'Clear process,' 'Clear object,' or 'Clear action' buttons.  If a desired term does not exist, a new term request may be made via Term Requests.  Event components may not be edited; to edit an event component, remove the existing event component and create a new one using the terms that you wish to add.  Further information on Event Components and Biological Context may be viewed on the attached pdf. More help
Process Object Action
egg quantity decreased

Key Event Overview

AOPs Including This Key Event

All of the AOPs that are linked to this KE will automatically be listed in this subsection. This table can be particularly useful for derivation of AOP networks including the KE. Clicking on the name of the AOP will bring you to the individual page for that AOP. More help
AOP Name Role of event in AOP Point of Contact Author Status OECD Status
Estrogen receptor agonism leading to reproductive dysfunction KeyEvent Tom Hutchinson (send email) Under Development: Contributions and Comments Welcome
Aromatase inhibition leading to reproductive dysfunction KeyEvent Dan Villeneuve (send email) Open for citation & comment WPHA/WNT Endorsed
Androgen receptor agonism leading to reproductive dysfunction KeyEvent Dan Villeneuve (send email) Open for citation & comment WPHA/WNT Endorsed
Estrogen receptor antagonism leading to reproductive dysfunction KeyEvent Dan Villeneuve (send email) Open for citation & comment EAGMST Under Review
Prolyl hydroxylase inhibition AdverseOutcome Dalma Martinovic-Weigelt (send email) Under Development: Contributions and Comments Welcome
Unknown MIE leading to reprodl AdverseOutcome Dalma Martinovic-Weigelt (send email) Under Development: Contributions and Comments Welcome
TPO inhibition and impaired fertility AdverseOutcome June-Woo Park (send email) Open for comment. Do not cite Under Development
AHR mediated epigenetic reproductive failure AdverseOutcome Jon Doering (send email) Under development: Not open for comment. Do not cite
5α-reductase,female fish KeyEvent Young Jun Kim (send email) Open for citation & comment Under Development
Deposition of energy leading to population decline via DSB and follicular atresia AdverseOutcome Knut Erik Tollefsen (send email) Under development: Not open for comment. Do not cite
Deposition of energy leading to population decline via DSB and apoptosis AdverseOutcome Knut Erik Tollefsen (send email) Under development: Not open for comment. Do not cite
Energy deposition leading to population decline via DNA oxidation and follicular atresia AdverseOutcome You Song (send email) Under development: Not open for comment. Do not cite
Energy deposition leading to population decline via DNA oxidation and oocyte apoptosis AdverseOutcome You Song (send email) Under development: Not open for comment. Do not cite

Taxonomic Applicability

Latin or common names of a species or broader taxonomic grouping (e.g., class, order, family) that help to define the biological applicability domain of the KE.In many cases, individual species identified in these structured fields will be those for which the strongest evidence used in constructing the AOP was available in relation to this KE. More help
Term Scientific Term Evidence Link
fathead minnow Pimephales promelas High NCBI
Fundulus heteroclitus Fundulus heteroclitus High NCBI
Oryzias latipes Oryzias latipes High NCBI

Life Stages

An indication of the the relevant life stage(s) for this KE. More help
Life stage Evidence
Adult, reproductively mature High

Sex Applicability

An indication of the the relevant sex for this KE. More help
Term Evidence
Female High

Key Event Description

A description of the biological state being observed or measured, the biological compartment in which it is measured, and its general role in the biology should be provided. More help

Spawning refers to the release of eggs. Cumulative fecundity refers to the total number of eggs deposited by a female, or group of females over a specified period of time.

How It Is Measured or Detected

A description of the type(s) of measurements that can be employed to evaluate the KE and the relative level of scientific confidence in those measurements.These can range from citation of specific validated test guidelines, citation of specific methods published in the peer reviewed literature, or outlines of a general protocol or approach (e.g., a protein may be measured by ELISA). Do not provide detailed protocols. More help

In laboratory-based reproduction assays (e.g., OECD Test No. 229; OECD Test No. 240), spawning and cumulative fecundity can be directly measured through daily observation of egg deposition and egg counts.

In some cases, fecundity may be estimated based on gonado-somatic index (OECD 2008).

Domain of Applicability

A description of the scientific basis for the indicated domains of applicability and the WoE calls (if provided).  More help

Cumulative fecundity and spawning can, in theory, be evaluated for any egg laying animal.

Regulatory Significance of the Adverse Outcome

An AO is a specialised KE that represents the end (an adverse outcome of regulatory significance) of an AOP. More help

Cumulative fecundity is the most apical endpoint considered in the OECD 229 Fish Short Term Reproduction Assay. The OECD 229 assay serves as screening assay for endocrine disruption and associated reproductive impairment (OECD 2012). Fecundity is also an important apical endpoint in the Medaka Extended One Generation Reproduction Test (MEOGRT; OECD Test Guideline 240; OECD 2015).

A variety of fish life cycle tests also include cumulative fecundity as an endpoint (OECD 2008).

References

List of the literature that was cited for this KE description. More help
  • OECD 2008. Series on testing and assessment, Number 95. Detailed Review Paper on Fish Life-cycle Tests. OECD Publishing, Paris. ENV/JM/MONO(2008)22.
  • OECD (2015), Test No. 240: Medaka Extended One Generation Reproduction Test (MEOGRT), OECD Publishing, Paris. DOI: http://dx.doi.org/10.1787/9789264242258-en
  • OECD. 2012a. Test no. 229: Fish short term reproduction assay. Paris, France:Organization for Economic Cooperation and Development.