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Aop: 216

AOP Title

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Excessive reactive oxygen species production leading to reproductive dysfunction

Short name:

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ROS production leading to reproductive dysfunction

Authors

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You Song1 and Knut Erik Tollefsen1,2
1 Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalléen 21, N-0349 Oslo, Norway
2 Norwegian University of Life Sciences (NMBU), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV). P.O. Box 5003, N-1432 Ås, Norway

 

Point of Contact

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Knut Erik Tollefsen

Contributors

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  • You Song
  • Knut Erik Tollefsen

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on June 30, 2017 12:36

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Revision dates for related pages

Page Revision Date/Time
Increase, DNA damage September 16, 2017 10:17
Increase, Apoptosis April 15, 2017 16:17
Decrease, Oogenesis April 15, 2017 16:20
Decrease, Ovulation September 16, 2017 10:15
Increase, Follicular atresia June 29, 2017 07:44
Decrease, Fertility June 29, 2017 08:09
Increase, Reactive oxygen species production September 16, 2017 10:14
Increase, DNA Damage leads to Increase, Apoptosis April 15, 2017 16:23
Increase, Apoptosis leads to Increase, Follicular atresia June 29, 2017 07:52
Increase, Follicular atresia leads to Decrease, Oogenesis June 29, 2017 07:52
Decrease, Oogenesis leads to Decrease, Ovulation April 15, 2017 16:24
Decrease, Ovulation leads to Decrease, Fertility April 15, 2017 16:24
Increase, ROS production leads to Increase, DNA Damage June 29, 2017 08:22
Gamma radiation April 15, 2017 16:04
Ultraviolet B radiation April 15, 2017 16:04

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Name Evidence Term
Gamma radiation Strong
Ultraviolet B radiation Strong

Molecular Initiating Event

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Title Short name
Increase, Reactive oxygen species production Increase, ROS production

Key Events

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Title Short name
Increase, DNA damage Increase, DNA Damage
Increase, Apoptosis Increase, Apoptosis
Decrease, Oogenesis Decrease, Oogenesis
Decrease, Ovulation Decrease, Ovulation
Increase, Follicular atresia Increase, Follicular atresia

Adverse Outcome

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Title Short name
Decrease, Fertility Decrease, Fertility

Relationships Between Two Key Events (Including MIEs and AOs)

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Title Directness Evidence Quantitative Understanding
Increase, DNA Damage leads to Increase, Apoptosis Directly leads to Strong
Increase, Apoptosis leads to Increase, Follicular atresia Directly leads to Moderate
Increase, Follicular atresia leads to Decrease, Oogenesis Directly leads to Moderate
Decrease, Oogenesis leads to Decrease, Ovulation Directly leads to Moderate
Decrease, Ovulation leads to Decrease, Fertility Directly leads to Strong
Increase, ROS production leads to Increase, DNA Damage Directly leads to Strong

Network View

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature Moderate

Taxonomic Applicability

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Term Scientific Term Evidence Link
Daphnia magna Daphnia magna Moderate NCBI
mice Mus sp. Strong NCBI

Sex Applicability

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Sex Evidence
Female Strong

Graphical Representation

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Click to download graphical representation template

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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