Stressor: 451

Title

Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help

Ionizing Radiation

Stressor Overview

A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help

AOPs Including This Stressor

This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help

AOP Name	Evidence
Increased DNA damage leading to increased risk of breast cancer	High
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer	High
Oxidative DNA damage leading to chromosomal aberrations and mutations	High
Deposition of energy leading to lung cancer	High
Increases in cellular reactive oxygen species (Chronic reactive oxygen species) leading to human treatment-resistant gastric cancer	Moderate
Deposition of energy leading to population decline via DNA strand breaks and follicular atresia	High
Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis	High
Deposition of ionizing energy leads to leading to population decline via inhibition of photosynthesis	High
Deposition of ionising energy leading to population decline via mitochondrial dysfunction	High
Deposition of ionising energy leading to population decline via programmed cell death	High
Deposition of energy leading to population decline via DNA oxidation and follicular atresia	High
Deposition of ionizing energy leads to population decline via impaired meiosis	High
Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation	High

Chemical Table

A list of chemicals associated with a prototypical stressor. More help

References

List of the literature that was cited for this prototypical stressor. More help

Durante, M., R. Orecchia, et al. (2017). "Charged-particle therapy in cancer: clinical uses and future perspectives." Nature reviews. Clinical oncology 14(8): 483-495.

Goodhead, D. T. (1988). "Spatial and temporal distribution of energy." Health physics 55(2): 231-240.

Goodhead, D. T. (1994). "Initial events in the cellular effects of ionizing radiations: clustered damage in DNA." International journal of radiation biology 65(1): 7-17.

Goodhead, D. T. and H. Nikjoo (1989). "Track structure analysis of ultrasoft X-rays compared to high- and low-LET radiations." International journal of radiation biology 55(4): 513-529.

Measurements), I. I. C. o. R. U. a. (1970). ICRU Report 16: Linear Energy Transfer. Washington, D.C., International Commission on Radiation Units and Measurements.