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Aop: 272

AOP Title

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Direct deposition of ionizing energy onto DNA leading to lung cancer

Short name:

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Direct ionzing energy leading to lung cancer

Graphical Representation

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Authors

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Vinita Chauhan, Health Canada

Zakaria Said, Health Canada

Baki Sadi, Health Canada

Carole Yauk, Health Canada

Danielle Beaton, Canadian Nuclear Laboratories

 

 

Point of Contact

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Vinita Chauhan   (email point of contact)

Contributors

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  • Vinita Chauhan

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on December 19, 2018 12:37

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Revision dates for related pages

Page Revision Date/Time
Direct Deposition of ionizing energy December 19, 2018 11:20
Increase DNA Double Strand Breaks December 19, 2018 11:22
Inadequate DNA repair December 19, 2018 11:22
Increase mutations December 19, 2018 11:23
Increase Chromosomal Aberrations December 19, 2018 11:24
Increase cell proliferation December 19, 2018 11:25
Increase lung cancer December 19, 2018 11:26
Ionizing energy leads to DNA DNA double strand breaks December 19, 2018 11:27
Ionizing energy leads to Increase mutations December 19, 2018 11:37
DNA DNA double strand breaks leads to DNA repair December 19, 2018 11:28
Ionizing energy leads to Increase chromosomal aberrations December 19, 2018 11:38
DNA repair leads to Increase mutations December 19, 2018 11:29
Increase mutations leads to Increase lung cancer December 19, 2018 11:39
Increase chromosomal aberrations leads to Increase lung cancer December 19, 2018 11:39
DNA repair leads to Increase chromosomal aberrations December 19, 2018 11:29
Increase mutations leads to Increase cell proliferation December 19, 2018 11:35
Increase chromosomal aberrations leads to Increase cell proliferation December 19, 2018 11:36
Increase cell proliferation leads to Increase lung cancer December 19, 2018 11:36

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1550 Direct Deposition of ionizing energy Ionizing energy
KE 1551 Increase DNA Double Strand Breaks DNA DNA double strand breaks
KE 1552 Inadequate DNA repair DNA repair
KE 1553 Increase mutations Increase mutations
KE 1554 Increase Chromosomal Aberrations Increase chromosomal aberrations
KE 1555 Increase cell proliferation Increase cell proliferation
AO 1556 Increase lung cancer Increase lung cancer

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Ionizing energy leads to DNA DNA double strand breaks adjacent High Moderate
DNA DNA double strand breaks leads to DNA repair adjacent Moderate Moderate
DNA repair leads to Increase mutations adjacent Moderate Moderate
DNA repair leads to Increase chromosomal aberrations adjacent Moderate Moderate
Increase mutations leads to Increase cell proliferation adjacent Low Low
Increase chromosomal aberrations leads to Increase cell proliferation adjacent Low Low
Increase cell proliferation leads to Increase lung cancer adjacent High Moderate
Ionizing energy leads to Increase mutations non-adjacent Moderate Moderate
Ionizing energy leads to Increase chromosomal aberrations non-adjacent Moderate Moderate
Increase mutations leads to Increase lung cancer non-adjacent Moderate Moderate
Increase chromosomal aberrations leads to Increase lung cancer non-adjacent Moderate Moderate

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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