API XML

Aop: 238

AOP Title

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Excessive reactive oxygen species production leading to population decline via lipid peroxidation

Short name:

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ROS production leading to population decline via LPO

Graphical Representation

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Click to download graphical representation template

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Authors

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You Song1 and Knut Erik Tollefsen1,2
1 Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, N-0349 Oslo, Norway
2 Norwegian University of Life Sciences (NMBU), P.O. Box 5003, N-1432 Ås, Norway

Point of Contact

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Knut Erik Tollefsen   (email point of contact)

Contributors

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  • You Song
  • Knut Erik Tollefsen

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on November 25, 2020 11:27

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Revision dates for related pages

Page Revision Date/Time
Decrease, Oogenesis April 30, 2020 16:41
Increase, Reactive oxygen species production September 16, 2017 10:14
Decrease, Fecundity June 12, 2018 04:39
Increase, Lipid peroxidation April 30, 2020 12:47
Increase, Apoptosis April 15, 2017 16:17
Increase, Follicular atresia November 25, 2020 11:19
Decrease, Population trajectory September 26, 2017 11:33
Increase, ROS production leads to Increase, LPO June 29, 2017 08:25
Increase, LPO leads to Increase, Apoptosis November 25, 2020 11:26
Increase, Apoptosis leads to Increase, Follicular atresia June 29, 2017 07:52
Increase, Follicular atresia leads to Decrease, Fecundity November 25, 2020 11:26
Decrease, Fecundity leads to Decrease, Population trajectory April 22, 2019 05:00
Gamma radiation April 15, 2017 16:04

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 257 Increase, Reactive oxygen species production Increase, ROS production
KE 1445 Increase, Lipid peroxidation Increase, LPO
KE 1365 Increase, Apoptosis Increase, Apoptosis
KE 1444 Increase, Follicular atresia Increase, Follicular atresia
5 KE 1366 Decrease, Oogenesis Decrease, Oogenesis
AO 328 Decrease, Fecundity Decrease, Fecundity
AO 360 Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, ROS production leads to Increase, LPO adjacent
Increase, LPO leads to Increase, Apoptosis adjacent
Increase, Apoptosis leads to Increase, Follicular atresia adjacent
Increase, Follicular atresia leads to Decrease, Fecundity adjacent
Decrease, Fecundity leads to Decrease, Population trajectory adjacent

Network View

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Stressors

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Name Evidence Term
Gamma radiation High

Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature High

Taxonomic Applicability

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Term Scientific Term Evidence Link
mice Mus sp. High NCBI
Daphnia magna Daphnia magna NCBI

Sex Applicability

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Sex Evidence
Female High

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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