API

Aop: 238

AOP Title

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Excessive reactive oxygen species production leading to reproductive failure

Short name:

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ROS production leading to reproductive failure

Authors

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You Song1 and Knut Erik Tollefsen1,2
1 Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalléen 21, N-0349 Oslo, Norway
2 Norwegian University of Life Sciences (NMBU), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV). P.O. Box 5003, N-1432 Ås, Norway

Point of Contact

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Knut Erik Tollefsen

Contributors

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  • You Song
  • Knut Erik Tollefsen

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on June 30, 2017 12:36

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Revision dates for related pages

Page Revision Date/Time
Increase, Lipid peroxidation June 29, 2017 08:04
Increase, Uncoupling of oxidative phosphorylation June 29, 2017 08:05
Decrease, Mitochondrial ATP production September 16, 2017 10:14
Decrease, Oogenesis April 15, 2017 16:20
Decrease, Ovulation September 16, 2017 10:15
Decrease, Fertility June 29, 2017 08:09
Increase, Reactive oxygen species production September 16, 2017 10:14
Increase, Lipid peroxidation leads to Increase, Uncoupling of OXPHOS June 29, 2017 08:10
Increase, Uncoupling of OXPHOS leads to Decrease, Mitochondrial ATP production June 29, 2017 08:11
Decrease, Mitochondrial ATP production leads to Decrease, Oogenesis June 29, 2017 08:11
Decrease, Oogenesis leads to Decrease, Ovulation April 15, 2017 16:24
Decrease, Ovulation leads to Decrease, Fertility April 15, 2017 16:24
Increase, ROS production leads to Increase, Lipid peroxidation June 29, 2017 08:25
Gamma radiation April 15, 2017 16:04
Ultraviolet B radiation April 15, 2017 16:04

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Name Evidence Term
Gamma radiation Strong
Ultraviolet B radiation Strong

Molecular Initiating Event

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Title Short name
Increase, Reactive oxygen species production Increase, ROS production

Key Events

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Title Short name
Increase, Lipid peroxidation Increase, Lipid peroxidation
Increase, Uncoupling of oxidative phosphorylation Increase, Uncoupling of OXPHOS
Decrease, Mitochondrial ATP production Decrease, Mitochondrial ATP production
Decrease, Oogenesis Decrease, Oogenesis
Decrease, Ovulation Decrease, Ovulation

Adverse Outcome

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Title Short name
Decrease, Fertility Decrease, Fertility

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature Strong

Taxonomic Applicability

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Term Scientific Term Evidence Link
mice Mus sp. Strong NCBI

Sex Applicability

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Sex Evidence
Female Strong

Graphical Representation

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Click to download graphical representation template

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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