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Aop: 238

AOP Title

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Excessive reactive oxygen species production leading to reduced ATP production-associated reproduction decline

Short name:

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ROS production leading to reproductive decline

Graphical Representation

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Click to download graphical representation template

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Authors

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You Song1 and Knut Erik Tollefsen1,2
1 Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalléen 21, N-0349 Oslo, Norway
2 Norwegian University of Life Sciences (NMBU), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV). P.O. Box 5003, N-1432 Ås, Norway

Point of Contact

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Knut Erik Tollefsen   (email point of contact)

Contributors

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  • You Song
  • Knut Erik Tollefsen

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on June 12, 2018 04:58

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Revision dates for related pages

Page Revision Date/Time
Increase, Uncoupling of oxidative phosphorylation June 29, 2017 08:05
Decrease, Mitochondrial ATP production September 16, 2017 10:14
Decrease, Oogenesis April 15, 2017 16:20
Decrease, Ovulation September 16, 2017 10:15
Increase, Reactive oxygen species production September 16, 2017 10:14
Decrease, Fecundity June 12, 2018 04:39
Increase, ROS production leads to Increase, Uncoupling of OXPHOS June 12, 2018 04:57
Increase, Uncoupling of OXPHOS leads to Decrease, Mitochondrial ATP production June 29, 2017 08:11
Decrease, Mitochondrial ATP production leads to Decrease, Oogenesis June 29, 2017 08:11
Decrease, Oogenesis leads to Decrease, Ovulation April 15, 2017 16:24
Decrease, Ovulation leads to Decrease, Fecundity June 12, 2018 04:44
Gamma radiation April 15, 2017 16:04
Ultraviolet B radiation April 15, 2017 16:04

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 257 Increase, Reactive oxygen species production Increase, ROS production
3 KE 1446 Increase, Uncoupling of oxidative phosphorylation Increase, Uncoupling of OXPHOS
4 KE 40 Decrease, Mitochondrial ATP production Decrease, Mitochondrial ATP production
5 KE 1366 Decrease, Oogenesis Decrease, Oogenesis
6 KE 488 Decrease, Ovulation Decrease, Ovulation
AO 328 Decrease, Fecundity Decrease, Fecundity

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, ROS production leads to Increase, Uncoupling of OXPHOS adjacent Moderate
Increase, Uncoupling of OXPHOS leads to Decrease, Mitochondrial ATP production adjacent High
Decrease, Mitochondrial ATP production leads to Decrease, Oogenesis adjacent Moderate
Decrease, Oogenesis leads to Decrease, Ovulation adjacent High
Decrease, Ovulation leads to Decrease, Fecundity adjacent High

Network View

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Stressors

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Name Evidence Term
Gamma radiation High
Ultraviolet B radiation High

Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature High

Taxonomic Applicability

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Term Scientific Term Evidence Link
mice Mus sp. High NCBI

Sex Applicability

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Sex Evidence
Female High

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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