API XML

Aop: 299

AOP Title

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S-adenosylmethionine depletion leading to reduced fecundity

Short name:

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SAM depletion leading to reduced fecundity

Graphical Representation

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Click to download graphical representation template

Authors

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You Song1 and Jorke Kamstra2

1 Section of Ecotoxicology and Risk Assessment, Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, NO-0349 Oslo, Norway. Email: yso@niva.no

2 Institute for Risk Assessment Sciences (IRAS), Utrecht University, Jeannette Donker-Voetgebouw
Yalelaan 104-106, Kamer 1.032, 3584 CM UtrechtUtrecht, Netherlands. Email: j.h.kamstra@uu.nl

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on May 30, 2019 08:22

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Revision dates for related pages

Page Revision Date/Time
Increase, S-adenosylmethionine depletion May 30, 2019 08:17
Increase, DNA hypomethylation April 22, 2019 04:53
Increase, Gene expression April 22, 2019 04:55
Decrease, Fecundity June 12, 2018 04:39
Increase, SAM depletion leads to Increase, DNA hypomethylation May 30, 2019 08:19
Increase, DNA hypomethylation leads to Increase, Gene expression April 22, 2019 04:59
Increase, Gene expression leads to Decrease, Fecundity April 22, 2019 05:00

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1652 Increase, S-adenosylmethionine depletion Increase, SAM depletion
KE 1620 Increase, DNA hypomethylation Increase, DNA hypomethylation
KE 1621 Increase, Gene expression Increase, Gene expression
AO 328 Decrease, Fecundity Decrease, Fecundity

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, SAM depletion leads to Increase, DNA hypomethylation adjacent High
Increase, DNA hypomethylation leads to Increase, Gene expression adjacent Low
Increase, Gene expression leads to Decrease, Fecundity adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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