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Key Event Title
Increased, Reactive oxygen species
|Level of Biological Organization|
Key Event Components
|reactive oxygen species||increased|
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP||Point of Contact||Author Status||OECD Status|
|unknown MIE renal failure||KeyEvent||Kellie Fay (send email)||Under Development: Contributions and Comments Welcome|
|Inhibition fatty acid beta oxidation leading to nonalcoholic steatohepatisis (NASH)||KeyEvent||Lyle Burgoon (send email)||Open for adoption|
|Frustrated phagocytosis-induced lung cancer||KeyEvent||Carole Seidel (send email)||Under development: Not open for comment. Do not cite||Under Development|
|ACE2 inhibition, liver fibrosis||KeyEvent||Young Jun Kim (send email)||Under development: Not open for comment. Do not cite|
|AT1R, lung fibrosis||KeyEvent||Young Jun Kim (send email)||Under development: Not open for comment. Do not cite|
|ACE/Ang-II/AT1R axis, chronic kidney disease (CKD)||KeyEvent||Young Jun Kim (send email)||Under development: Not open for comment. Do not cite|
|Deposition of ionizing energy leads to population decline via impaired meiosis||MolecularInitiatingEvent||Erica Maremonti (send email)||Under development: Not open for comment. Do not cite|
|Frustrated phagocytosis leads to malignant mesothelioma||KeyEvent||Nureddin Mansour (send email)||Under development: Not open for comment. Do not cite|
|All life stages||High|
Key Event Description
Biological State: increased reactive oxygen species (ROS)
Biological compartment: an entire cell -- may be cytosolic, may also enter organelles.
General role in biology: ROS are a natural product of metabolism. Typically the cell has enough anti-oxidant reducers available to mitigate any potential toxicity from ROS.
How It Is Measured or Detected
ROS is typically measured using flourscence or measurements of specific chemical markers.
Domain of Applicability
ROS is a normal constituent found in all organisms.