Key Event Title
|Level of Biological Organization|
Key Event Components
|reactive oxygen species||increased|
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP|
|unknown MIE renal failure||KeyEvent|
|Inhibition fatty acid beta oxidation leading to nonalcoholic steatohepatisis (NASH)||KeyEvent|
|Frustrated phagocytosis-induced lung cancer||KeyEvent|
|Wnt activation leading to cancer malignancy||MolecularInitiatingEvent|
|All life stages||High|
Key Event Description
Biological State: increased reactive oxygen species (ROS)
Biological compartment: an entire cell -- may be cytosolic, may also enter organelles.
General role in biology: ROS are a natural product of metabolism. Typically the cell has enough anti-oxidant reducers available to mitigate any potential toxicity from ROS.
How It Is Measured or Detected
ROS is typically measured using flourscence or measurements of specific chemical markers.
Domain of Applicability
ROS is a normal constituent found in all organisms.
Evidence for Perturbation by Stressor
Overview for Molecular Initiating Event