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Aop: 330

AOP Title

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Excessive reactive oxygen species production leading to mortality (#4)

Short name:

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Excessive ROS leading to mortality (#4)

Graphical Representation

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Click to download graphical representation template

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Authors

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You Songa, b, *, Li Xiea, b, c, YeonKyeong Leeb,d, Knut Erik Tollefsena, b, c

a Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, N-0349 OSLO, Norway

b Centre for Environmental Radioactivity (CERAD), Norwegian University of Life Sciences (NMBU), Post box 5003, N-1432 Ås, Norway

c Norwegian University of Life Sciences (NMBU), Faculty of Environmental Sciences and Natural Resource Management (MINA), Post box 5003, N-1432 Ås, Norway

d Norwegian University of Life Sciences (NMBU), Faculty of Biosciences, P.O. Box 5003, N-1432 Ås, Norway

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on April 30, 2020 13:55

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Revision dates for related pages

Page Revision Date/Time
Increase, Reactive oxygen species production September 16, 2017 10:14
Increase, Oxidative DNA damage March 19, 2019 09:40
Increase, DNA double-strand break April 30, 2020 12:28
Increase, Apoptosis April 15, 2017 16:17
Increase, Mortality December 03, 2016 16:33
Increase, ROS production leads to Increase,Oxidative DNA damage April 30, 2020 13:53
Increase, Apoptosis leads to Increase, Mortality June 12, 2018 04:30
Increase,Oxidative DNA damage leads to Increase, DNA DSB April 30, 2020 13:54
Increase, DNA DSB leads to Increase, Apoptosis April 30, 2020 12:30
Ultraviolet B radiation April 15, 2017 16:04

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 257 Increase, Reactive oxygen species production Increase, ROS production
KE 1608 Increase, Oxidative DNA damage Increase,Oxidative DNA damage
KE 1766 Increase, DNA double-strand break Increase, DNA DSB
KE 1365 Increase, Apoptosis Increase, Apoptosis
AO 350 Increase, Mortality Increase, Mortality

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, ROS production leads to Increase,Oxidative DNA damage adjacent High Low
Increase,Oxidative DNA damage leads to Increase, DNA DSB adjacent Moderate Low
Increase, DNA DSB leads to Increase, Apoptosis adjacent Moderate Low
Increase, Apoptosis leads to Increase, Mortality non-adjacent Moderate Low

Network View

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Stressors

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Name Evidence Term
Ultraviolet B radiation High

Life Stage Applicability

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Life stage Evidence
All life stages

Taxonomic Applicability

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Term Scientific Term Evidence Link
Daphnia magna Daphnia magna NCBI

Sex Applicability

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Sex Evidence
Unspecific

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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