Essential element imbalance leads to reproductive failure via oxidative stress

Of the originating work:

Janaina da Silva (Department of General Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil)

Reggiani Vilela Gonçalves (Department of Animal Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil)

Fabiana Cristina Silveira Alves de Melo (Department of Animal Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil)

Mariáurea Matias Sarandy (Department of Animal Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil)

Sérgio Luis Pinto da Matta (Department of General Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil and Department of Animal Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil)

Of the content populated in the AOP-Wiki:

Travis Karschnik (General Dynamics Information Technology, Duluth, MN, USA.)

The authors perfromed a bibliography search using the electronic databases Medline/PubMed (https://www.ncbi.nlm.nih.gov/pubmed) and Scopus (https://www.scopus.com/ home.uri), on September 21, 2018, at 2:13 p.m. For all databases, the search filters were based on three complementary levels: (i) animals, (ii) testis, and (iii) cadmium, which were combined by Boolean connectors [AND].  An initial selection based on title and abstract was performed where pre-clinical studies in murine models were included that assessed the Cd effect on testicular architecture that did or did not perform molecular, biochemical, and/or hormonal analyses.  All timings, frequencies, routes, and dosages of Cd (and compounds)exposure were eligible for inclusion.  The authors excluded studies that didn't evaluate the Cd exposure in the testicular histomorphology of murine models.  Data extraction was based on (i) characteristics of publication: authors, publication year, and country; (ii) characteristics of the experimental animals: animal model, age, weight, number of animals, number of animals per group, and number of groups; (iii) exposure: compounds, doses, periodicity of administration, route, duration, and existence of a control group; (iv) main histomorphological outcomes and analyses as well as the main molecular, biochemical, and hormonal results related with the histomorphological alterations; and (v) secondary outcomes.  The quality of the studies was assessed by the criteria described on the SYRCLE’s Risk of Bias (RoB) tool (Systematic Review Centre for Laboratory Animal Experimentation) designed specifically for animal studies.  Thirty-seven (37) records were included in the systematic review.

The scope of this project was limited to representing the AOP(s) as presented in the originating publication.  No editorilization   The literature used to support this AOP and its constituent pages began with the originating publication and followed to the primary, secondary, and tertiary works cited therein. 

KE and KER page creation and re-use was determined using Handbook principles where page re-use was preferred.  Once a baseline level of information was populated for the AOP the authors of the originating publication were contacted for collaboration.

Efforts were made not to editorialize or otherwise add any content to the AOP or its constituent pages that weren’t provided in the primary, secondary, or tertiary literature.  In some cases, however, descriptive content was added to pages e.g., assays on a KE page, even if they weren’t specifically provided in the literature stemming from the originating publication.