Event: 1758

Key Event Title


Impaired, Spermatogenesis

Short name


Impaired, Spermatogenesis

Biological Context


Level of Biological Organization

Organ term


Organ term

Key Event Components


Process Object Action
Abnormal spermatogenesis Mature sperm cell abnormal

Key Event Overview

AOPs Including This Key Event


AOP Name Role of event in AOP
PPARa Agonism Impairs Fish Reproduction KeyEvent



Taxonomic Applicability


Term Scientific Term Evidence Link
Vertebrates Vertebrates High NCBI

Life Stages


Life stage Evidence
Adult, reproductively mature High

Sex Applicability


Term Evidence
Male High

Key Event Description


How It Is Measured or Detected


Domain of Applicability


Taxonomic Applicability: The relevance for invertebrates has not been evaluated. 

Life Stage Applicability: Only applicable for sexually mature adults

Sex Applicability: Only applicable to males

Evidence for Perturbation by Stressor


Flutamide impairs spermatogenesis in adult male zebrafish (Yin et al., 2017)

Male fathead minnows exposed to flutamide show spermatocyte degredation and necrosis in their testis (Jensen et al., 2004)


A review of androgen signaling in male fish cites several studies showing vinclozolin decreases sperm quality (Golshan et al., 2019)

Bis(2-ethylhexyl) phthalate

A review of androgen signaling in male fish cites several studies showing DEHP decreases sperm quality (Golshan et al., 2019)



Golshan, M. & S.M.H. Alvai (2019) “Androgen signaling in male fishes: Examples of anti-androgenic chemicals that cause reproductive disorders”, Theriogenology, Vol. 139, Elsevier, pp. 58-71. https://doi.org/10.1016/j.theriogenology.2019.07.020 

Jensen, K.M. et al. (2004) “Characterization of responses to the antiandrogen flutamide in a short-term reproduction assay with the fathead minnow”, Aquatic Toxicology, Vol. 70(2), Elsevier, pp. 99-110. https://doi.org/10.1016/j.aquatox.2004.06.012 

Yin, P. et al. (2017) “Diethylstilbestrol, flutamide and their combination impaired the spermatogenesis of male adult zebrafish through disrupting HPG axis, meiosis and apoptosis”, Aquatic Toxicology, Vol. 185, Elsevier, pp. 129-137. https://doi.org/10.1016/j.aquatox.2017.02.013