API

Event: 1758

Key Event Title

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Impaired, Spermatogenesis

Short name

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Impaired, Spermatogenesis

Biological Context

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Level of Biological Organization
Organ


Organ term

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Organ term
testis


Key Event Components

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Process Object Action
Abnormal spermatogenesis Mature sperm cell abnormal

Key Event Overview


AOPs Including This Key Event

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Stressors

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Vertebrates Vertebrates High NCBI

Life Stages

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Life stage Evidence
Adult, reproductively mature High

Sex Applicability

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Term Evidence
Male High

Key Event Description

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How It Is Measured or Detected

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Domain of Applicability

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Taxonomic Applicability: The relevance for invertebrates has not been evaluated. 

Life Stage Applicability: Only applicable for sexually mature adults

Sex Applicability: Only applicable to males


Evidence for Perturbation by Stressor



Flutamide

Flutamide impairs spermatogenesis in adult male zebrafish (Yin et al., 2017)

Male fathead minnows exposed to flutamide show spermatocyte degredation and necrosis in their testis (Jensen et al., 2004)


Vinclozolin

A review of androgen signaling in male fish cites several studies showing vinclozolin decreases sperm quality (Golshan et al., 2019)


Bis(2-ethylhexyl) phthalate

A review of androgen signaling in male fish cites several studies showing DEHP decreases sperm quality (Golshan et al., 2019)


References

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Golshan, M. & S.M.H. Alvai (2019) “Androgen signaling in male fishes: Examples of anti-androgenic chemicals that cause reproductive disorders”, Theriogenology, Vol. 139, Elsevier, pp. 58-71. https://doi.org/10.1016/j.theriogenology.2019.07.020 

Jensen, K.M. et al. (2004) “Characterization of responses to the antiandrogen flutamide in a short-term reproduction assay with the fathead minnow”, Aquatic Toxicology, Vol. 70(2), Elsevier, pp. 99-110. https://doi.org/10.1016/j.aquatox.2004.06.012 

Yin, P. et al. (2017) “Diethylstilbestrol, flutamide and their combination impaired the spermatogenesis of male adult zebrafish through disrupting HPG axis, meiosis and apoptosis”, Aquatic Toxicology, Vol. 185, Elsevier, pp. 129-137. https://doi.org/10.1016/j.aquatox.2017.02.013