AOPs Including This Stressor
|Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity||High|
Events Including This Stressor
|User term||DTXID||Preferred name||Casrn||jchem_inchi_key||indigo_inchi_key|
There is no evidence text for this AOP
Cadmium (Cd) decreased CFTR protein expression in Calu-3 cells in a dose- and time-dependent manner. CFTR transcript levels, however, appeared to only be transiently affected. Reduced CFTR expression at the plasma membrane was associated with a reduction in CFTR Cl− conductance. Treatment of cells with NAC did not rescue CFTR expression in Cd-treated cells. In contrast, co-treatment with α-tocopherol prevented CFTR inhibition, and this effect was linked to α-tocopherol suppressing the accumulation of ubiquitinated CFTR (Rennolds et al., 2010).